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Mounting studies have highlighted the pivotal influence of anti-silencing function 1B (ASF1B) on the malignancy of cancers.To explore the influence and mechanism of ASF1B in colorectal cancer (CRC).Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect mRNA expression of ASF1B. Immunohistochemical staining was performed to detect protein expression of ASF1B and Ki67 in tumor tissues. Western blot analysis was used to determine levels of ASF1B and proliferation/epithelial mesenchymal transition (EMT)/stemness-related proteins. In addition, the proliferation of CRC cells was assessed using Cell Counting Kit-8 and 5-Ethynyl-2'-Deoxyuridine assays. The migration and invasion of CRC cells were evaluated using transwell assays. Stemness of CRC cells was tested using the sphere formation assay. To construct a xenograft tumor model, HCT116 cells were introduced into mouse flanksASF1B expression was markedly increased in CRC tissues and cells, and it was inversely correlated with overall survival of CRC patients and was positively associated with the tumor node metastasis (TNM) stage of CRC patients. Silencing of ASF1B suppressed proliferation, migration, invasion, stemness and EMT of CRC cells as well as tumorigenesis of xenograft mice. Furthermore, protein levels of P-phosphatidylinositol 3-kinase (p-PI3K) and p-AKT were decreased after silencing of ASF1B in CRC cells. The inhibitory effects of ASF1B knockdown on cell proliferation, stemness and EMT were partly abolished by PI3K activator in CRC cells.Silencing of ASF1B inactivated the PI3K/AKT pathway to suppress CRC malignancy

A Mg(OtBu)2-catalyzed C(sp3)–H oxidation of α-azido arylethanones to straightforwardly produce primary α-ketoamides is presented.

The drying of compact and biologically active materials presents significant challenges. In this study, we propose using electrostatic field–ultrasonic coupling pretreatment to enhance the drying efficiency of ginkgo fruits. We designed and constructed an experimental device to investigate the effects of ultrasonic power, pretreatment time, hot air drying temperature, and electrostatic field voltage on the moisture content of the fruits. We used the response surface methodology to identify optimal process conditions and further explored the kinetic model for the moisture content of the fruits under the pretreatment. The results showed that the optimal process parameters for electrostatic–ultrasound pretreatment and the drying of ginkgo fruits were: an electrostatic field voltage of 11.252 kV, an ultrasound power of 590.074 W, a pretreatment time of 32.799 min, and a hot air drying temperature of 85 °C. Under the optimized process conditions, the correlation between the moisture content of ginkgo fruits and the two-term drying kinetics model was the highest. After electrostatic–ultrasound coupling pretreatment, the drying rate of ginkgo fruits was significantly improved during hot air drying.

Two non-ionic hydro-fluorocarbon hybrid surfactants with and without hydroxyl groups were synthesized and compared. They exhibited good thermal stability and superior surface activity. It was observed that the hydroxyl group had a profound effect on modifying the surface tension of their solutions and the morphology of the formed micelles. This effect may be attributed to the rearranging of the alkane group from above the air/aqueous surface to below it and the disrupting of the interfacial water structure induced by the hydroxyl groups. This work provides a strategy to weaken the immiscibility between hydrocarbon and fluorocarbon chains by modifying their orientational structure at the interface, thus it is helpful for the design of surfactants with varied interfacial properties.

This study conducted a meta-analysis to compare the effectiveness and safety of the negative pressure wound therapy (NPWT) with the moist wound care (MWC) in the treatment of diabetic foot ulcers (DFUs).The PubMed, EMBASE, and CENTRAL were searched by 2 of the authors, to identify randomized controlled trials comparing the clinical outcomes of patients treated with NPWT versus MWC for DFUs. Meta-analyses were performed for several outcomes, including wound healing results, amputation or resection incidence, and risk of adverse events, utilizing the "meta" package of R language version 4.0.3.A total of 10 trials (619 patients in NPWT group and 625 in MWC group) and 8 trials were included for the qualitative and quantitative syntheses, respectively. As a result, significantly lower risk of non-closure of the wound (risk ratio [RR] = 0.74, 95% confidence interval [CI]: 0.63-0.87; P = .001), lower average wound area (standard mean difference = -0.80, 95% CI: -1.54 to -0.06; P = .034), more wound area decrease (standard mean difference = 0.81, 95% CI: 0.36-1.26; P = .001), increased appearance rate of granulation tissue (RR = 1.61, 95% CI: 1.07-2.41; P-0.021), and lower risk of amputation or resection (RR = 0.70, 95% CI: 0.50-0.99; P = .045), were demonstrated for the NPWT group when compared to MWC group. However, no statistically significant difference was found for the disappearance rate of wound discharge at 8 weeks, the rate of blood culture positivity, VAS-pain score, and the overall frequency of adverse events between the 2 treatment groups (P = .05).NPWT could accelerate process of the wound healing, and decrease the risk of post-treatment amputation or resection, without any additional frequency of adverse events, when compared with MWC, in patients with DFUs.

To systematically evaluate the clinical efficacy and safety of Compound Danshen Dripping Pills combined with conventional antihypertensive drugs in the treatment of hypertensive left ventricular hypertrophy. China National Knowledge Infrastructure(CNKI), Wanfang, VIP, PubMed, EMbase, Cochrane Library, Ovid and Web of Science databases were searched by computer to retrieve the randomized controlled trials(RCTs) of Compound Danshen Dripping Pills combined with conventional antihypertensive drugs in the treatment of hypertensive left ventricular hypertrophy from the establishment of databases to July 2020. After two researchers performed data retrieval, data extraction, and risk assessment of bias, they used RevMan 5.3 software for Meta-analysis. A total of 10 RCTs were included, with a total of 979 patients. Meta-analysis results showed that in terms of interventricular septal thickness(MD=-0.70, 95%CI[-1.15,-0.24], P=0.003), left ventricular posterior wall thickness(MD=-0.81, 95%CI[-1.41,-0.21], P=0.008), left ventricular mass index(MD=-8.75, 95%CI[-17.40,-0.10], P=0.05), systolic blood pressure(MD=-8.97, 95%CI[-13.46,-4.48], Plt;0.000 1), diastolic blood pressure(MD=-5.87, 95%CI[-8.39,-3.34], Plt;0.000 01) and left ventricular end-diastolic diameter(MD=-1.73, 95%CI[-2.38,-1.08], Plt;0.000 01), Compound Danshen Dripping Pills combined with conventional antihypertensive drugs was superior to conventional antihypertensive drugs. In terms of left ventricular ejection fraction(MD=0.41, 95%CI[-0.74, 1.55], P=0.49), there was no statistical difference in treatment between the two groups. Because of the small amount of literatures included in the safety aspect, it is impossible to give an accurate conclusion. The GRADE score showed that the level of evidence was low and extremely low. The results show that the Compound Danshen Dripping Pills combined with conventional antihypertensive drugs may effectively improve the clinical efficacy for hypertensive ventricular hypertrophy, and the safety needs to be further explored. Due to the low quality of the included literatures, more high-quality RCTs are needed for verification.

Highly regio- and diastereoselective Reformatsky reaction of stable, chiral fluoroalkyl α,β-unsaturated N-tert-butanesulfinyl ketimines was developed, which provided an efficient method for the asymmetric synthesis of structurally diverse β-tetrasubstituted β-fluoroalkyl β-vinyl β-amino esters in good yields and with excellent diastereoselectivities (dr up to 96:4).

There is an increasing demand to solve the environmental dissemination problems of fluorosurfactants and improve their responsive behavior, surface properties, chemical stability and foaming performance. In this work, three pH-responsive fluorosurfactants, named F9-es-mor, F9-N3-mor and F9-N2-mor, were synthesized by facile one-step esterification or amidation. The F9-N2-mor efficiently reduced the water surface tension to 14.56 mN·m−1 with a low critical micelle concentration (CMC) of 0.20 mM. More importantly, both F9-N2-mor and F9-N3-mor obviously displayed reproducible pH-response foaming behaviors at an optimal pH of 6.0 and 8.0, respectively, probably owing to their rigid molecular structure, strong intermolecular H-bond and high membrane elasticity. Besides, the morpholine fluorosurfactants defoam at pH below 4.0, indicating that these fluorosurfactants could be recycled and their residue could be easily removed. Overall, the novel fluorosurfactants F9-N2-mor might provide new inspiration to recycle fluorosurfactants as well as construct pH-responsive foams.

By using molecular twisting and bulky side group substitution, we successfully develop two deep-blue emitters, BiPI-1 and BiPI-2 . These two twisted linear molecules retain the excellent photophysical and electrical properties of planar analogue and remarkably supress redshifts in solid state emission. Especially, BiPI-1 showed deep-blue emission in both solution and solid phase, and high carrier mobilities with μ h > 10 −3 cm 2 V −1 s −1 and μ e > 10 −5 cm 2 V −1 s −1 . Standard blue electroluminescence (color purity: (0.15, 0.08)) and high device efficiency (CE: 4.62 cd A −1 , EQE: 6.18%) were observed in a non-doped OLED of BiPI-1 .

Two nonionic Gemini fluorocarbon surfactants containing ecofriendly ester-bonded, named as MN-2C9F19 and EN-2C9F19 were designed and synthesized by one-step esterification. Their surface properties, wettability, thermal properties, and foaming characterization were systematically studied. Two surfactants exhibited high surface activity in aqueous solution, with surface tension (γcmc) of 14.20 mN/m for MN-2C9F19 and 13.71 mN/m for EN-2C9F19. Moreover, MN-2C9F19 and EN-2C9F19 showed high decomposition temperature (Td) of up to 165.4 °C and 176.7 °C respectively. Although the structural difference between methyl and ethyl group is negligible, their wettability and foaming properties are quite different. EN-2C9F19 could wet the low surface energy PTEF plate completely at low concentration (0.6 mM) but MN-2C9F19 needed higher concentration (1.2 mM). Also, EN-2C9F19 exhibited much better foaming property with the foam integrated value F up to 4,370,500 mL·s while MN-2C9F19 could reach up to 2,732,580 mL·s. This maybe ascribe to lower surface tension and higher viscosity of EN-2C9F19 solution. Furthermore, two surfactants showed stronger foaming properties at high temperatures than the conventional foam surfactant SDBS even at room temperature. This work provided an easy synthesis route to develop high-performance foaming agents at high temperatures.

Innovation ecosystem of hi-tech enterprises is a knowledge difference, coexistence and co-evolution innovation system based on component/module. Based on contract and trust, platform enterprises and supporting enterprises establish control coupling, information coupling and relationship coupling in the form of loose coupling. Technology standard becomes the basic coupling route of innovation ecosystem because of its unique competitive connotation. The ecosystem build motivate mechanism of price incentives, reputation incentives, information incentives and eliminated incentives to achieve the coupling effect of collaborative innovation.

In magnetic resonance imaging (MRI), Gibbs artifact is often introduced by the reconstruction involving only part of the k-space data. The current methods of Gibbs artifact reduction are generally based on the k-space data. In this paper, an image processing method based on inverse diffusion is proposed. This method is directly applied to the MR images, which can achieve the reduction of artifacts while enhancing the edge by the diffusion of pixel gray value. Experiments showed that the Gibbs artifact was effectively reduced and the valuable details of the images were maintained.

This article introduce the method of acquiring the syndrome related to the syndrome elements based on the rough set theory. Through the JOHNSON experimental study on spleen and YANG asthenia, we have a set of related data and then analyzed the result.

A 67-year-old gentleman presented with a 1-day history of left foot pain. He had recently been discharged following a coronary artery bypass graft; during the admission, he had received an intravenous heparin infusion. Examination revealed black-purple discolouration of the first and second digits of the left foot with pitting oedema to the level of the knee. The posterior tibial and dorsalis pedis pulses were both shown to be patent. A new thrombocytopenia was noted. Ultrasound imaging revealed multiple deep vein thrombosis. The history of recent heparin exposure coupled with venous gangrene secondary to deep vein thrombosis was consistent with heparin-induced thrombocytopenia. He was treated acutely with intravenous danaparoid and later with warfarin. There was complete resolution of the venous gangrene at 1 month follow-up.