32 results on '"Ying, Wenqin"'
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2. High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects
3. Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos
4. Prediction and Validation of Mouse Meiosis-Essential Genes Based on Spermatogenesis Proteome Dynamics
5. Mini-dCas13X-mediated RNA editing restores dystrophin expression in a humanized mouse model of Duchenne muscular dystrophy
6. Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
7. GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos
8. A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects
9. Optimization of C-to-G base editors with sequence context preference predictable by machine learning methods
10. Base editing-mediated splicing correction therapy for spinal muscular atrophy
11. Tild-CRISPR Allows for Efficient and Precise Gene Knockin in Mouse and Human Cells
12. In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice
13. Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors
14. Interspecies blastocyst complementation generates functional rat cell-derived forebrain tissues in mice
15. High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects
16. High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effect
17. High-fidelity base editor with no detectable genome-wide off-target effects
18. Prediction of meiosis-essential genes based on dynamic proteomes responsive to spermatogenesis
19. Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development
20. Disruption of splicing-regulatory elements using CRISPR/Cas9 to rescue spinal muscular atrophy in human iPSCs and mice
21. Base editing generates substantial off-target single nucleotide variants
22. Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing
23. CRISPR/Cas9-mediated targeted chromosome elimination
24. One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs
25. CRISPR/Cas9 – Mediated Precise Targeted Integration In Vivo Using a Double Cut Donor with Short Homology Arms
26. Homology-mediated end joining-based targeted integration using CRISPR/Cas9
27. Disruption of splicing-regulatory elements using CRISPR/Cas9 to rescue spinal muscular atrophy in human iPSCs and mice.
28. Effects of Histone Deacetylase Inhibitor Oxamflatin onIn VitroPorcine Somatic Cell Nuclear Transfer Embryos
29. The heterogeneity and dynamic equilibrium of rat embryonic stem cells
30. Pluripotin Combined with Leukemia Inhibitory Factor Greatly Promotes the Derivation of Embryonic Stem Cell Lines from Refractory Strains
31. Nuclear reprogramming: the zygotic transcription program is established through an “erase-and-rebuild” strategy
32. Effects of Histone Deacetylase Inhibitor Oxamflatin on In Vitro Porcine Somatic Cell Nuclear Transfer Embryos.
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