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31 results on '"Yinda, Kwe Claude"'

1. Jamaican fruit bat (Artibeus jamaicensis) insusceptibility to mucosal inoculation with SARS-CoV-2 Delta variant is not caused by receptor compatibility

Author

Port, Julia R., Riopelle, Jade C., van Tol, Sarah, Wickenhagen, Arthur, Bohrnsen, Eric, Sturdevant, Daniel E., Rosenke, Rebecca, Lovaglio, Jamie, Lack, Justin, Anzick, Sarah L., Cordova, Kathleen, Yinda, Kwe Claude, Hanley, Patrick W., Schountz, Tony, Kendall, Lon V., Shaia, Carl I., Saturday, Greg, Martens, Craig, Schwarz, Benjamin, and Munster, Vincent J.

Published
2024
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2. Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses.

Author

Morris, Dylan H, Yinda, Kwe Claude, Gamble, Amandine, Rossine, Fernando W, Huang, Qishen, Bushmaker, Trenton, Fischer, Robert J, Matson, M Jeremiah, Van Doremalen, Neeltje, Vikesland, Peter J, Marr, Linsey C, Munster, Vincent J, and Lloyd-Smith, James O

Subjects
Humans, Virus Inactivation, Humidity, Models, Biological, Hot Temperature, COVID-19, SARS-CoV-2, environmental stability, epidemiology, global health, humidity, infectious disease, microbiology, temperature, virus, Prevention, Emerging Infectious Diseases, Infectious Diseases, Biochemistry and Cell Biology
Abstract

Ambient temperature and humidity strongly affect inactivation rates of enveloped viruses, but a mechanistic, quantitative theory of these effects has been elusive. We measure the stability of SARS-CoV-2 on an inert surface at nine temperature and humidity conditions and develop a mechanistic model to explain and predict how temperature and humidity alter virus inactivation. We find SARS-CoV-2 survives longest at low temperatures and extreme relative humidities (RH); median estimated virus half-life is >24 hr at 10°C and 40% RH, but ∼1.5 hr at 27°C and 65% RH. Our mechanistic model uses fundamental chemistry to explain why inactivation rate increases with increased temperature and shows a U-shaped dependence on RH. The model accurately predicts existing measurements of five different human coronaviruses, suggesting that shared mechanisms may affect stability for many viruses. The results indicate scenarios of high transmission risk, point to mitigation strategies, and advance the mechanistic study of virus transmission.

Published
2021

3. Histopathology and SARS-CoV-2 Cellular Localization in Eye Tissues of COVID-19 Autopsies

Author

Stein, Sydney R., Ramelli, Sabrina C., Ramos-Benitez, Marcos J., Platt, Andrew P., Dickey, James M., Curran, Shelly J., Babyak, Ashley L., Valencia, Luis Perez, Richert, Mary E., Vannella, Kevin M., Chertow, Daniel S., Kleiner, David E., Hewitt, Stephen M., Young, Willie J., Young, Sarah P., Gasmi, Billel, De Melo, Michelly Sampaio, Desar, Sabina, Tadros, Saber, Nasir, Nadia, Jin, Xueting, Rajan, Sharika, Dikoglu, Esra, Ozkaya, Neval, Ylaya, Kris, Chung, Joon-Yong, Pittaluga, Stefania, Smith, Grace, Emanuel, Elizabeth R., Kelsall, Brian, Olivera, Justin A., Blawas, Megan, Grazioli, Alison, Hays, Nicole, Purcell, Madeleine, Singireddy, Shreya, Wu, Jocelyn, Raja, Katherine, Curto, Ryan, Chung, Jean, Borth, Amy, Bowers, Kimberly, Weichold, Anne, Minor, Paula, Moshref, Mirahmad, Kelly, Emily, Sajadi, Mohammad M., Scalea, Thomas M., Tran, Douglas, Madathil, Ronson J., Dahi, Siamak, Deatrick, Kristopher B., Krause, Eric M., Rabin, Joseph, Herrold, Joseph A., Tabatabai, Ali, Hochberg, Eric, Cornachione, Christopher, Levine, Andrea R., Saharia, Kapil K., Richards, Justin E., Elder, John, Burke, Allen, Mazzeffi, Michael A., Christenson, Robert, Chancer, Zackary, Abdulmahdi, Mustafa, Sopha, Sabrina, Goldberg, Tyler, Soherwardi, Shahabuddin, Sangwan, Yashvir, McCurdy, Michael T., Sudano, Kristen, Blume, Diane, Radin, Bethany, Arnouk, Madhat, Eagan, James W., Jr., Herr, Daniel L., Zerbe, Christa, Sen, H. Nida, Wang, Yujuan, Kodati, Shilpa, Lee, Jung Wha, Perez, Paola, Singh, Manmeet, Yinda, Kwe Claude, Platt, Andrew, Munster, Vincent J., de Wit, Emmie, Warner, Blake M., and Chan, Chi-Chao

Published
2023
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4. Cell restriction factors, and not receptor compatibility, block Jamaican fruit bat (Artibeus jamaicensis) susceptibility to mucosal inoculation with SARS-CoV-2 Delta variant

Author

Port, Julia R., primary, Riopelle, Jade C., additional, Tol, Sarah van, additional, Wickenhagen, Arthur, additional, Bohrnsen, Eric, additional, Sturdevant, Daniel E., additional, Rosenke, Rebecca, additional, Lovaglio, Jamie, additional, Lack, Justin, additional, Anzick, Sarah L., additional, Cordova, Kathleen, additional, Yinda, Kwe Claude, additional, Hanley, Patrick W., additional, Schountz, Tony, additional, Kendall, Lon V., additional, Shaia, Carl I., additional, Saturday, Greg, additional, Martens, Craig, additional, Schwarz, Benjamin, additional, and Munster, Vincent J., additional

Published
2024
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5. Histopathology and SARS-CoV-2 cellular localization in eye tissues of COVID-19 autopsies

Author

Sen, H. Nida, primary, Vannella, Kevin M., additional, Wang, Yujuan, additional, Chung, Joon-Yong, additional, Kodati, Shilpa, additional, Ramelli, Sabrina C., additional, Lee, Jung Wha, additional, Perez, Paola, additional, Stein, Sydney R., additional, Grazioli, Alison, additional, Dickey, James M., additional, Ylaya, Kris, additional, Singh, Manmeet, additional, Yinda, Kwe Claude, additional, Platt, Andrew, additional, Ramos-Benitez, Marcos J., additional, Zerbe, Christa, additional, Munster, Vincent J., additional, de Wit, Emmie, additional, Warner, Blake M, additional, Herr, Daniel L., additional, Rabin, Joseph, additional, Saharia, Kapil K, additional, Kleiner, David E., additional, Hewitt, Stephen M., additional, Chan, Chi-Chao, additional, Chertow, Daniel S., additional, Platt, Andrew P., additional, Curran, Shelly J., additional, Babyak, Ashley L., additional, Valencia, Luis Perez, additional, Richert, Mary E., additional, Young, Willie J., additional, Young, Sarah P., additional, Gasmi, Billel, additional, De Melo, Michelly Sampaio, additional, Desar, Sabina, additional, Tadros, Saber, additional, Nasir, Nadia, additional, Jin, Xueting, additional, Rajan, Sharika, additional, Dikoglu, Esra, additional, Ozkaya, Neval, additional, Pittaluga, Stefania, additional, Smith, Grace, additional, Emanuel, Elizabeth R., additional, Kelsall, Brian, additional, Olivera, Justin A., additional, Blawas, Megan, additional, Hays, Nicole, additional, Purcell, Madeleine, additional, Singireddy, Shreya, additional, Wu, Jocelyn, additional, Raja, Katherine, additional, Curto, Ryan, additional, Chung, Jean, additional, Borth, Amy, additional, Bowers, Kimberly, additional, Weichold, Anne, additional, Minor, Paula, additional, Moshref, Mirahmad, additional, Kelly, Emily, additional, Sajadi, Mohammad M., additional, Scalea, Thomas M., additional, Tran, Douglas, additional, Madathil, Ronson J., additional, Dahi, Siamak, additional, Deatrick, Kristopher B., additional, Krause, Eric M., additional, Herrold, Joseph A., additional, Tabatabai, Ali, additional, Hochberg, Eric, additional, Cornachione, Christopher, additional, Levine, Andrea R., additional, Saharia, Kapil K., additional, Richards, Justin E., additional, Elder, John, additional, Burke, Allen, additional, Mazzeffi, Michael A., additional, Christenson, Robert, additional, Chancer, Zackary, additional, Abdulmahdi, Mustafa, additional, Sopha, Sabrina, additional, Goldberg, Tyler, additional, Soherwardi, Shahabuddin, additional, Sangwan, Yashvir, additional, McCurdy, Michael T., additional, Sudano, Kristen, additional, Blume, Diane, additional, Radin, Bethany, additional, Arnouk, Madhat, additional, and Eagan, James W., additional

Published
2023
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8. A monoclonal antibody targeting the Nipah virus fusion glycoprotein apex imparts protection from disease

Author

Avanzato, Victoria A., primary, Bushmaker, Trenton, additional, Oguntuyo, Kasopefoluwa Y., additional, Yinda, Kwe Claude, additional, Duyvesteyn, Helen M. E., additional, Stass, Robert, additional, Meade-White, Kimberly, additional, Rosenke, Rebecca, additional, Thomas, Tina, additional, Saturday, Greg, additional, Doores, Katie J., additional, Lee, Benhur, additional, Bowden, Thomas A., additional, and Munster, Vincent J., additional

Published
2022
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11. Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses

Author

Morris, Dylan H., Yinda, Kwe Claude, Gamble, Amandine, Rossine, Fernando W., Huang, Qishen, Bushmaker, Trenton, Fischer, Robert J., Matson, M. Jeremiah, Van Doremalen, Neeltje, Vikesland, Peter J., Marr, Linsey C., Munster, Vincent J., and Lloyd-Smith, James O.

Abstract

Ambient temperature and humidity strongly affect inactivation rates of enveloped viruses, but a mechanistic, quantitative theory of these effects has been elusive. We measure the stability of SARS-CoV-2 on an inert surface at nine temperature and humidity conditions and develop a mechanistic model to explain and predict how temperature and humidity alter virus inactivation. We find SARS-CoV-2 survives longest at low temperatures and extreme relative humidities (RH); median estimated virus half-life is >24 hr at 10 degrees C and 40% RH, but similar to 1.5 hr at 27 degrees C and 65% RH. Our mechanistic model uses fundamental chemistry to explain why inactivation rate increases with increased temperature and shows a U-shaped dependence on RH. The model accurately predicts existing measurements of five different human coronaviruses, suggesting that shared mechanisms may affect stability for many viruses. The results indicate scenarios of high transmission risk, point to mitigation strategies, and advance the mechanistic study of virus transmission. National Science FoundationNational Science Foundation (NSF) [CCF 1917819, DEB-1557022, RC-2635, CBET-1705653, CBET-2029911]; Defense Advanced Research Projects AgencyUnited States Department of DefenseDefense Advanced Research Projects Agency (DARPA) [D18AC00031]; UCLA AIDS Institute; Charity Treks Amandine Gamble Published version National Science Foundation CCF 1917819 Dylan H Morris Defense Advanced Research Projects Agency D18AC00031 Amandine Gamble James O Lloyd-Smith; UCLA AIDS Institute and Charity Treks Amandine Gamble James O Lloyd-Smith; National Institute of Allergy and Infectious Diseases Intramural Research Program Kwe Claude Yinda Trenton Bushmaker Robert J Fischer M Jeremiah Matson Neeltje Van Doremalen Vincent J Munster National Science Foundation DEB-1557022 James O Lloyd-Smith Strategic Environmental Research and Development Program RC-2635 James O Lloyd-Smith; National Science Foundation CBET-1705653 Qishen Huang Peter J Vikesland Linsey C Marr; National Science Foundation CBET-2029911 Qishen Huang Peter J Vikesland Linsey C Marr

Published
2021

12. Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses

Author

Morris, Dylan H, primary, Yinda, Kwe Claude, additional, Gamble, Amandine, additional, Rossine, Fernando W, additional, Huang, Qishen, additional, Bushmaker, Trenton, additional, Fischer, Robert J, additional, Matson, M Jeremiah, additional, Van Doremalen, Neeltje, additional, Vikesland, Peter J, additional, Marr, Linsey C, additional, Munster, Vincent J, additional, and Lloyd-Smith, James O, additional

Published
2021
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13. At least seven distinct rotavirus genotype constellations in bats with evidence of reassortment and zoonotic transmissions

Author

Simsek, Ceren, Corman, Victor Max, Everling, Hermann Ulrich, Lukashev, Alexander N., Rasche, Andrea, Maganga, Gaël Darren, Binger, Tabea, Jansen, Daan, Beller, Leen, Deboutte, Ward, Gloza-Rausch, Florian, Seebens-Hoyer, Antje, Yordanov, Stoian, Sylverken, Augustina, Oppong, Samuel, Adu Sarkodie, Yaw, Vallo, Peter, Leroy, Eric M., Bourgarel, Mathieu, Yinda, Kwe Claude, Van Ranst, Eric, Drosten, Christian, Drexler, Jan Felix, Matthijnssens, Jelle, Simsek, Ceren, Corman, Victor Max, Everling, Hermann Ulrich, Lukashev, Alexander N., Rasche, Andrea, Maganga, Gaël Darren, Binger, Tabea, Jansen, Daan, Beller, Leen, Deboutte, Ward, Gloza-Rausch, Florian, Seebens-Hoyer, Antje, Yordanov, Stoian, Sylverken, Augustina, Oppong, Samuel, Adu Sarkodie, Yaw, Vallo, Peter, Leroy, Eric M., Bourgarel, Mathieu, Yinda, Kwe Claude, Van Ranst, Eric, Drosten, Christian, Drexler, Jan Felix, and Matthijnssens, Jelle

Abstract

Bats host many viruses pathogenic to humans, and increasing evidence suggests that rotavirus A (RVA) also belongs to this list. Rotaviruses cause diarrheal disease in many mammals and birds, and their segmented genomes allow them to reassort and increase their genetic diversity. Eighteen out of 2,142 bat fecal samples (0.8%) collected from Europe, Central America, and Africa were PCR-positive for RVA, and 11 of those were fully characterized using viral metagenomics. Upon contrasting their genomes with publicly available data, at least 7 distinct bat RVA genotype constellations (GCs) were identified, which included evidence of reassortments and 6 novel genotypes. Some of these constellations are spread across the world, whereas others appear to be geographically restricted. Our analyses also suggest that several unusual human and equine RVA strains might be of bat RVA origin, based on their phylogenetic clustering, despite various levels of nucleotide sequence identities between them. Although SA11 is one of the most widely used reference strains for RVA research and forms the backbone of a reverse genetics system, its origin remained enigmatic. Remarkably, the majority of the genotypes of SA11-like strains were shared with Gabonese bat RVAs, suggesting a potential common origin. Overall, our findings suggest an underexplored genetic diversity of RVAs in bats, which is likely only the tip of the iceberg. Increasing contact between humans and bat wildlife will further increase the zoonosis risk, which warrants closer attention to these viruses. IMPORTANCE The increased research on bat coronaviruses after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) allowed the very rapid identification of SARS-CoV-2. This is an excellent example of the importance of knowing viruses harbored by wildlife in general, and bats in particular, for global preparedness against emerging viral pathogens. The current effort

Published
2021

14. At Least Seven Distinct Rotavirus Genotype Constellations in Bats with Evidence of Reassortment and Zoonotic Transmissions

Author

Simsek, Ceren, primary, Corman, Victor Max, additional, Everling, Hermann Ulrich, additional, Lukashev, Alexander N., additional, Rasche, Andrea, additional, Maganga, Gael Darren, additional, Binger, Tabea, additional, Jansen, Daan, additional, Beller, Leen, additional, Deboutte, Ward, additional, Gloza-Rausch, Florian, additional, Seebens-Hoyer, Antje, additional, Yordanov, Stoian, additional, Sylverken, Augustina, additional, Oppong, Samuel, additional, Sarkodie, Yaw Adu, additional, Vallo, Peter, additional, Leroy, Eric M., additional, Bourgarel, Mathieu, additional, Yinda, Kwe Claude, additional, Van Ranst, Marc, additional, Drosten, Christian, additional, Drexler, Jan Felix, additional, and Matthijnssens, Jelle, additional

Published
2021
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15. Author response: Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses

Author

Morris, Dylan H, primary, Yinda, Kwe Claude, additional, Gamble, Amandine, additional, Rossine, Fernando W, additional, Huang, Qishen, additional, Bushmaker, Trenton, additional, Fischer, Robert J, additional, Matson, M Jeremiah, additional, Van Doremalen, Neeltje, additional, Vikesland, Peter J, additional, Marr, Linsey C, additional, Munster, Vincent J, additional, and Lloyd-Smith, James O, additional

Published
2021
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16. Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses

Author

Morris, Dylan H., primary, Yinda, Kwe Claude, additional, Gamble, Amandine, additional, Rossine, Fernando W., additional, Huang, Qishen, additional, Bushmaker, Trenton, additional, Fischer, Robert J., additional, Matson, M. Jeremiah, additional, Doremalen, Neeltje van, additional, Vikesland, Peter J., additional, Marr, Linsey C., additional, Munster, Vincent J., additional, and Lloyd-Smith, James O., additional

Published
2020
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17. Persistence of SARS-CoV-2 in Water and Wastewater

Author

Bivins, Aaron, primary, Greaves, Justin, additional, Fischer, Robert, additional, Yinda, Kwe Claude, additional, Ahmed, Warish, additional, Kitajima, Masaaki, additional, Munster, Vincent J., additional, and Bibby, Kyle, additional

Published
2020
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19. At least seven distinct rotavirus genotype constellations in bats with evidence of reassortment and zoonotic transmissions

Author

Simsek, Ceren, primary, Corman, Victor Max, additional, Everling, Hermann Ulrich, additional, Lukashev, Alexander N., additional, Rasche, Andrea, additional, Maganga, Gael Darren, additional, Binger, Tabea, additional, Jansen, Daan, additional, Beller, Leen, additional, Deboutte, Ward, additional, Gloza-Rausch, Florian, additional, Seebens-Hoyer, Antje, additional, Yordanov, Stoian, additional, Sylverken, Augustina, additional, Oppong, Samuel, additional, Sarkodie, Yaw Adu, additional, Vallo, Peter, additional, Leroy, Eric M., additional, Bourgarel, Mathieu, additional, Yinda, Kwe Claude, additional, Van Ranst, Marc, additional, Drosten, Christian, additional, Drexler, Jan Felix, additional, and Matthijnssens, Jelle, additional

Published
2020
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25. Low eukaryotic viral richness is associated with faecal microbiota transplantation success in patients with UC

Author

Conceição-Neto, Nádia, primary, Deboutte, Ward, additional, Dierckx, Tim, additional, Machiels, Kathleen, additional, Wang, Jun, additional, Yinda, Kwe Claude, additional, Maes, Piet, additional, Van Ranst, Marc, additional, Joossens, Marie, additional, Raes, Jeroen, additional, Vermeire, Séverine, additional, and Matthijnssens, Jelle, additional

Published
2017
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29. UV-C light completely blocks highly contagious Delta SARS-CoV-2 aerosol transmission in hamsters.

Author

Fischer RJ, Port JR, Holbrook MG, Yinda KC, Creusen M, Ter Stege J, de Samber M, and Munster VJ

Abstract

Behavioral and medical control measures are not effective in containing the spread of SARS-CoV-2. Here we report on the effectiveness of a preemptive environmental strategy using UV-C light to prevent airborne transmission of the virus in a hamster model and show that UV-C exposure completely prevents airborne transmission between individuals.

Published
2022
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30. Heat-treated virus inactivation rate depends strongly on treatment procedure: illustration with SARS-CoV-2.

Author

Gamble A, Fischer RJ, Morris DH, Yinda KC, Munster VJ, and Lloyd-Smith JO

Abstract

Decontamination helps limit environmental transmission of infectious agents. It is required for the safe re-use of contaminated medical, laboratory and personal protective equipment, and for the safe handling of biological samples. Heat treatment is a common decontamination method, notably used for viruses. We show that for liquid specimens (here, solution of SARS-CoV-2 in cell culture medium), virus inactivation rate under heat treatment at 70°C can vary by almost two orders of magnitude depending on the treatment procedure, from a half-life of 0.86 min (95% credible interval: [0.09, 1.77]) in closed vials in a heat block to 37.00 min ([12.65, 869.82]) in uncovered plates in a dry oven. These findings suggest a critical role of evaporation in virus inactivation via dry heat. Placing samples in open or uncovered containers may dramatically reduce the speed and efficacy of heat treatment for virus inactivation. Given these findings, we reviewed the literature temperature-dependent coronavirus stability and found that specimen containers, and whether they are closed, covered, or uncovered, are rarely reported in the scientific literature. Heat-treatment procedures must be fully specified when reporting experimental studies to facilitate result interpretation and reproducibility, and must be carefully considered when developing decontamination guidelines.

Published
2021
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31. Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses.

Author

Morris DH, Yinda KC, Gamble A, Rossine FW, Huang Q, Bushmaker T, Fischer RJ, Matson MJ, van Doremalen N, Vikesland PJ, Marr LC, Munster VJ, and Lloyd-Smith JO

Abstract

Environmental conditions affect virus inactivation rate and transmission potential. Understanding those effects is critical for anticipating and mitigating epidemic spread. Ambient temperature and humidity strongly affect the inactivation rate of enveloped viruses, but a mechanistic, quantitative theory of those effects has been elusive. We measure the stability of the enveloped respiratory virus SARS-CoV-2 on an inert surface at nine temperature and humidity conditions and develop a mechanistic model to explain and predict how temperature and humidity alter virus inactivation. We find SARS-CoV-2 survives longest at low temperatures and extreme relative humidities; median estimated virus half-life is over 24 hours at 10 °C and 40 % RH, but approximately 1.5 hours at 27 °C and 65 % RH. Our mechanistic model uses simple chemistry to explain the increase in virus inactivation rate with increased temperature and the U-shaped dependence of inactivation rate on relative humidity. The model accurately predicts quantitative measurements from existing studies of five different human coronaviruses (including SARS-CoV-2), suggesting that shared mechanisms may determine environmental stability for many enveloped viruses. Our results indicate scenarios of particular transmission risk, point to pandemic mitigation strategies, and open new frontiers in the mechanistic study of virus transmission.

Published
2020
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