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1. Single-Cell Sequencing and Organoids: A Powerful Combination for Modelling Organ Development and Diseases

Author

Yin, Yuebang, Liu, Peng-Yu, Shi, Yinghua, Li, Ping, Pedersen, Stine Helene Falsig, Editor-in-Chief, Barber, Diane L., Series Editor, Cordat, Emmanuelle, Series Editor, Kajimura, Mayumi, Series Editor, Leipziger, Jens G., Series Editor, O'Donnell, Martha E., Series Editor, Pardo, Luis A., Series Editor, Schmitt, Nicole, Series Editor, and Stock, Christian, Series Editor

Published
2021
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6. Hepatitis E Virus Infects Neurons and Brains

Author

Zhou, Xinying, Huang, Fen, Xu, Lei, Lin, Zhanmin, de Vrij, Femke M. S., Ayo-Martin, Ane C., van der Kroeg, Mark, Zhao, Manzhi, Yin, Yuebang, Wang, Wenshi, Cao, Wanlu, Wang, Yijin, Kushner, Steven A., Peron, Jean Marie, Alric, Laurent, de Man, Robert A., Jacobs, Bart C., van Eijk, Jeroen J., Aronica, Eleonora M. A., Sprengers, Dave, Metselaar, Herold J., de Zeeuw, Chris I., Dalton, Harry R., Kamar, Nassim, Peppelenbosch, Maikel P., and Pan, Qiuwei

Published
2017

21. Modeling liver cancer and therapy responsiveness using organoids derived from primary mouse liver tumors

Author

Cao, Wanlu, primary, Liu, Jiaye, additional, Wang, Ling, additional, Li, Meng, additional, Verstegen, Monique M A, additional, Yin, Yuebang, additional, Ma, Buyun, additional, Chen, Kan, additional, Bolkestein, Michiel, additional, Sprengers, Dave, additional, van der Laan, Luc J W, additional, Doukas, Michael, additional, Kwekkeboom, Jaap, additional, Smits, Ron, additional, Peppelenbosch, Maikel P, additional, and Pan, Qiuwei, additional

Published
2018
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25. The RNA genome of hepatitis E virus robustly triggers an antiviral interferon response

Author

Wang, Wenshi, primary, Wang, Yijin, additional, Qu, Changbo, additional, Wang, Shan, additional, Zhou, Jianhua, additional, Cao, Wanlu, additional, Xu, Lei, additional, Ma, Buyun, additional, Hakim, Mohamad S., additional, Yin, Yuebang, additional, Li, Tiancheng, additional, Peppelenbosch, Maikel P., additional, Zhao, Jingmin, additional, and Pan, Qiuwei, additional

Published
2018
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27. Inhibition of Calcineurin or IMP Dehydrogenase Exerts Moderate to Potent Antiviral Activity against Norovirus Replication

Author

Dang, Wen, primary, Yin, Yuebang, additional, Wang, Yijin, additional, Wang, Wenshi, additional, Su, Junhong, additional, Sprengers, Dave, additional, van der Laan, Luc J. W., additional, Felczak, Krzysztof, additional, Pankiewicz, Krzysztof W., additional, Chang, Kyeong-Ok, additional, Koopmans, Marion P. G., additional, Metselaar, Herold J., additional, Peppelenbosch, Maikel P., additional, and Pan, Qiuwei, additional

Published
2017
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28. Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury

Author

Cao, Wanlu, primary, Chen, Kan, additional, Bolkestein, Michiel, additional, Yin, Yuebang, additional, Verstegen, Monique M.A., additional, Bijvelds, Marcel J.C., additional, Wang, Wenshi, additional, Tuysuz, Nesrin, additional, ten Berge, Derk, additional, Sprengers, Dave, additional, Metselaar, Herold J., additional, van der Laan, Luc J.W., additional, Kwekkeboom, Jaap, additional, Smits, Ron, additional, Peppelenbosch, Maikel P., additional, and Pan, Qiuwei, additional

Published
2017
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30. RIG‐I is a key antiviral interferon‐stimulated gene against hepatitis E virus regardless of interferon production

Author

Xu, Lei, primary, Wang, Wenshi, additional, Li, Yunlong, additional, Zhou, Xinying, additional, Yin, Yuebang, additional, Wang, Yijin, additional, de Man, Robert A., additional, van der Laan, Luc J.W., additional, Huang, Fen, additional, Kamar, Nassim, additional, Peppelenbosch, Maikel P., additional, and Pan, Qiuwei, additional

Published
2017
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31. Unphosphorylated ISGF3 drives constitutive expression of interferon-stimulated genes to protect against viral infections

Author

Wang, Wenshi, primary, Yin, Yuebang, additional, Xu, Lei, additional, Su, Junhong, additional, Huang, Fen, additional, Wang, Yijin, additional, Boor, Patrick P. C., additional, Chen, Kan, additional, Wang, Wenhui, additional, Cao, Wanlu, additional, Zhou, Xinying, additional, Liu, Pengyu, additional, van der Laan, Luc J. W., additional, Kwekkeboom, Jaap, additional, Peppelenbosch, Maikel P., additional, and Pan, Qiuwei, additional

Published
2017
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32. Biological or pharmacological activation of protein kinase C alpha constrains hepatitis E virus replication

Author

Wang, Wenshi, primary, Wang, Yijin, additional, Debing, Yannick, additional, Zhou, Xinying, additional, Yin, Yuebang, additional, Xu, Lei, additional, Herrera Carrillo, Elena, additional, Brandsma, Johannes H., additional, Poot, Raymond A., additional, Berkhout, Ben, additional, Neyts, Johan, additional, Peppelenbosch, Maikel P., additional, and Pan, Qiuwei, additional

Published
2017
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33. Modeling liver cancer and therapy responsiveness using organoids derived from primary mouse liver tumors.

Author

Cao, Wanlu, Liu, Jiaye, Wang, Ling, Li, Meng, Verstegen, Monique M A, Yin, Yuebang, Ma, Buyun, Chen, Kan, Bolkestein, Michiel, Sprengers, Dave, Laan, Luc J W van der, Doukas, Michael, Kwekkeboom, Jaap, Smits, Ron, Peppelenbosch, Maikel P, and Pan, Qiuwei

Subjects
LIVER cancer, CANCER treatment, ORGANOIDS
Abstract

The current understanding of cancer biology and development of effective treatments for cancer remain far from satisfactory. This in turn heavily relies on the availability of easy and robust model systems that resemble the architecture/physiology of the tumors in patients to facilitate research. Cancer research in vitro has mainly been based on the use of immortalized 2D cancer cell lines that deviate in many aspects from the original primary tumors. The recent development of the organoid technology allowing generation of organ-buds in 3D culture from adult stem cells has endowed the possibility of establishing stable culture from primary tumors. Although culturing organoids from liver tumors is thought to be difficult, we now convincingly demonstrate the establishment of organoids from mouse primary liver tumors. We have succeeded in culturing 91 lines from 129 liver tissue/tumors. These organoids can be grown in long-term cultures in vitro. About 20% of these organoids form tumors in immunodeficient mice upon (serial) transplantation, confirming their tumorigenic and self-renewal properties. Interestingly, single cells from the tumor organoids have high efficiency of organoid initiation, and a single organoid derived from a cancer cell is able to initiate a tumor in mice, indicating the enrichment of tumor-initiating cells in the tumor organoids. Furthermore, these organoids recapitulate, to some extent, the heterogeneity of liver cancer in patients, with respect to phenotype, cancer cell composition and treatment response. These model systems shall provide enormous opportunities to advance our research on liver cancer (stem cell) biology, drug development and personalized medicine. [ABSTRACT FROM AUTHOR]

Published
2019
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34. Mycophenolic acid potently inhibits rotavirus infection with a high barrier to resistance development

Author

Yin, Yuebang, primary, Wang, Yijin, additional, Dang, Wen, additional, Xu, Lei, additional, Su, Junhong, additional, Zhou, Xinying, additional, Wang, Wenshi, additional, Felczak, Krzysztof, additional, van der Laan, Luc J.W., additional, Pankiewicz, Krzysztof W., additional, van der Eijk, Annemiek A., additional, Bijvelds, Marcel, additional, Sprengers, Dave, additional, de Jonge, Hugo, additional, Koopmans, Marion P.G., additional, Metselaar, Herold J., additional, Peppelenbosch, Maikel P., additional, and Pan, Qiuwei, additional

Published
2016
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36. Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV

Author

Wang, Wenshi, primary, Xu, Lei, additional, Brandsma, Johannes H., additional, Wang, Yijin, additional, Hakim, Mohamad S., additional, Zhou, Xinying, additional, Yin, Yuebang, additional, Fuhler, Gwenny M., additional, van der Laan, Luc J. W., additional, van der Woude, C. Janneke, additional, Sprengers, Dave, additional, Metselaar, Herold J., additional, Smits, Ron, additional, Poot, Raymond A., additional, Peppelenbosch, Maikel P., additional, and Pan, Qiuwei, additional

Published
2016
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37. PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target.

Author

Yin, Yuebang, Dang, Wen, Zhou, Xinying, Xu, Lei, Wang, Wenshi, Cao, Wanlu, Chen, Sunrui, Su, Junhong, Cai, Xuepeng, Xiao, Shaobo, Peppelenbosch, Maikel P., and Pan, Qiuwei

Subjects
*ROTAVIRUS diseases, *ANTIVIRAL agents, *IMMUNOCOMPROMISED patients, *MTOR protein, *AUTOPHAGY, *DRUG development
Abstract

Rotavirus infection is a major cause of severe dehydrating diarrhea in infants younger than 5 y old and in particular cases of immunocompromised patients irrespective to the age of the patients. Although vaccines have been developed, antiviral therapy is an important complement that cannot be substituted. Because of the lack of specific approved treatment, it is urgent to facilitate the cascade of further understanding of the infection biology, identification of druggable targets and the final development of effective antiviral therapies. PI3K-Akt-mTOR signaling pathway plays a vital role in regulating the infection course of many viruses. In this study, we have dissected the effects of PI3K-Akt-mTOR signaling pathway on rotavirus infection using both conventional cell culture models and a 3D model of human primary intestinal organoids. We found that PI3K-Akt-mTOR signaling is essential in sustaining rotavirus infection. Thus, blocking the key elements of this pathway, including PI3K, mTOR and 4E-BP1, has resulted in potent anti-rotavirus activity. Importantly, a clinically used mTOR inhibitor, rapamycin, potently inhibited both experimental and patient-derived rotavirus strains. This effect involves 4E-BP1 mediated induction of autophagy, which in turn exerts anti-rotavirus effects. These results revealed new insights on rotavirus-host interactions and provided new avenues for antiviral drug development. [ABSTRACT FROM AUTHOR]

Published
2018
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38. Radiometric characterisation of Dunhuang satellite calibration test site (China)

Author

Wu, D., Yin, Yuebang, Wang, Z., Gu, Xing Fa, Verbrugghe, Morgane, Guyot, G., ProdInra, Migration, Unité de bioclimatologie, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1997

39. Diet, aberrant crypt foci and colorectal cancer

Author

Bruce, W.R., Archer, M.C., Corpet, Denis E., Medline, A., Minkin, S., Stamp, D., Yin, Yuebang, Zhang, X.M., ProdInra, Migration, Xénobiotiques, Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], CARCINOGENESE, CANCER, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1993

40. Opposing Effects of Nitazoxanide on Murine and Human Norovirus.

Author

Wen Dang, Yuebang Yin, Peppelenbosch, Maikel P., Qiuwei Pan, Dang, Wen, Yin, Yuebang, and Pan, Qiuwei

Subjects
NOROVIRUSES, ANTIPROTOZOAL agents, ANTIVIRAL agents, VIRUS diseases, CLINICAL trials, THERAPEUTICS
Abstract

The article discuses the clinical trials in which substantial evidence suggested that nitazoxanide or antiprotozoal agent is a potential antiviral therapy for norovirus infection. It states that the clinical trials and case studies have reported that therapeutic use of nitazoxanide has reduced symptom duration in the immuno-competent patients or free from infection in the immuno-compromised patients.

Published
2017
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41. N-Acetyl-D-glucosamine improves the intestinal development and nutrient absorption of weaned piglets via regulating the activity of intestinal stem cells

Author

Wang, Zhaobin, Hu, Jie, Yang, Xinyuan, Yin, Lanmei, Wang, Min, Yin, Yuebang, Li, Jianzhong, Yang, Huansheng, and Yin, Yulong

Abstract

Early weaning in piglets can cause a series of negative effects. This causes serious losses to the livestock industry. N-Acetyl-D-glucosamine (D-GlcNAc) plays an important role in regulating the homeostasis of the intestine. This study aimed to investigate the effects of D-GlcNAc on the growth performance and intestinal function of weaned piglets. Twenty-four weaned piglets ([Yorkshire × Landrace] × Duroc, 6.58 ± 0.15 kg, n = 8) at 21 d old were fed 3 diets supplemented with 0 (control), 1 and 3 g/kg D-GlcNAc. The intestinal organoid model was used to verify the regulatory mechanism of D-GlcNAc on intestinal epithelial cells. On the whole, supplementation of D-GlcNAc in the piglet diet has no significant effect on the growth performance and diarrhoea of weaned piglets (P > 0.05). The apparent digestibility of nutrients and mRNA abundance of nutrient transporters in the 1 g/kg D-GlcNAc group were increased significantly (P < 0.05). D-GlcNAc did not affect villus height (VH) and crypt depth (CD) but resulted in a numerically shorter VH and shallower CD, which lead to an increase in ileal VH:CD ratio (P < 0.05). Cell shedding rates in the ileum villi increased (P < 0.05). The relative length and weight of the small intestine of weaned piglets increased (P < 0.05). In vitro studies found that the budding rates of organoids treated with 0.1 mmol/L D-GlcNAc increased on the d 3 and 5 (P < 0.05). The average budding numbers per budding organoid treated with 0.1 and 10 mmol/L D-GlcNAc increased on d 3 (P < 0.05). D-GlcNAc upregulated leucine rich repeat containing G protein-coupled receptor 5 (Lgr5+) and Chromogranin A mRNA abundance in organoids (P < 0.05). Mucin 2 (Muc2) expression increased when treated with 1 and 10 mmol/L D-GlcNAc (P < 0.05). In conclusion, dietary D-GlcNAc cannot improve the growth performance of weaned piglets. However, it can promote the growth and development of the intestinal tract and improve the digestion and absorption capacity of the intestine, which is achieved by affecting the activity of intestinal stem cells.

Published
2021
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42. Changes in progenitors and differentiated epithelial cells of neonatal piglets

Author

Yin, Lanmei, Li, Jun, Zhang, Yitong, Yang, Qing, Yang, Cuiyan, Yi, Zhenfeng, Yin, Yuebang, Wang, Qiye, Li, Jianzhong, Ding, Nengshui, Zhang, Zhigang, Yang, Huansheng, and Yin, Yulong

Abstract

This study aimed to assess the changes of small intestinal morphology, progenitors, differentiated epithelial cells, and potential mechanisms in neonatal piglets. Hematoxylin and eosin staining of samples from 36 piglets suggested that dramatic changes were observed in the jejunum crypts depth and crypt fission index of neonatal piglets (P < 0.001). The number of intestinal stem cells (ISC) tended to increase (P < 0.10), and a decreased number of enteroendocrine cells appeared in the jejunal crypt on d 7 (P < 0.05). Furthermore, the mRNA expression of jejunal chromogranin A(ChgA) was down-regulated in d 7 piglets (P < 0.05). There was an up-regulation of the adult ISC marker gene of SPARC related modular calcium binding 2 (Smoc2), and Wnt/β-catenin target genes on d 7 (P < 0.05). These results were further verified in vitro enteroid culture experiments. A mass of hollow spheroids was cultured from the fetal intestine of 0-d-old piglets (P < 0.001), whereas substantial organoids with budding and branching structures were cultured from the intestine of 7-d-old piglets (P < 0.001). The difference was reflected by the organoid budding efficiency, crypt domains per organoid, and the surface area of the organoid. Furthermore, spheroids on d 0 had more Ki67-positive cells and enteroendocrine cells (P < 0.05) and showed a decreasing trend in the ISC and goblet cells (P < 0.10). Moreover, the mRNA expression of spheroids differed markedly from that of organoids, with low expression of intestinal differentiation gene (Lysozyme; P < 0.05), epithelial-specific markers (Villin, E-cadherin; P < 0.05), and adult ISC markers (leucine-rich repeat-containing G protein-coupled receptor 5 [Lgr5], Smoc2; P < 0.001), and up-regulation of fetal marker (connexin 43 [Cnx43]; P < 0.05). The mRNA expression of relevant genes was up-regulated, and involved in Wnt/β-catenin, epidermal growth factor (EGF), Notch, and bone morphogenetic protein (BMP) signaling on d 7 organoids (P < 0.05). Spheroids displayed low differentiated phenotype and high proliferation, while organoids exhibited strong differentiation potential. These results indicated that the conversion from the fetal progenitors (spheroids) to adult ISC (normal organoids) might largely be responsible for the fast development of intestinal epithelial cells in neonatal piglets.

Published
2021
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