Search

Your search keyword '"Yin, Xiaoyu"' showing total 469 results
Start Over Author "Yin, Xiaoyu"
469 results on '"Yin, Xiaoyu"'

3. Improvement of Cloud Platform Utilization Based on Evaluation and Optimization of Computing Resource Runtime Surplus Capacity

Author

Gong, Shuai, Yin, Xiaoyu, Zhang, Min, Cao, Wanwan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Hung, Jason C., editor, Yen, Neil, editor, and Chang, Jia-Wei, editor

Published
2024
Full Text
View/download PDF

5. Large-scale application of ClinGen-InSiGHT APC-specific ACMG/AMP variant classification criteria leads to substantial reduction in VUS

Author

Yin, Xiaoyu, Richardson, Marcy, Laner, Andreas, Shi, Xuemei, Ognedal, Elisabet, Vasta, Valeria, Hansen, Thomas v.O., Pineda, Marta, Ritter, Deborah, de Dunnen, Johan, Hassanin, Emadeldin, Lin, Wencong Lyman, Borras, Ester, Krahn, Karl, Nordling, Margareta, Martins, Alexandra, Mahmood, Khalid, Nadeau, Emily, Beshay, Victoria, Tops, Carli, Genuardi, Maurizio, Pesaran, Tina, Frayling, Ian M., Capellá, Gabriel, Latchford, Andrew, Tavtigian, Sean V., Maj, Carlo, Plon, Sharon E., Greenblatt, Marc S., Macrae, Finlay A., Spier, Isabel, and Aretz, Stefan

Published
2024
Full Text
View/download PDF

12. Interaction Mechanism of Moderately Oxidized Myofibrillar Proteins with Selected Aldehyde Compounds

Author

DAI Xinxin, LÜ Yichao, YIN Xiaoyu, DOU Qingzhe, KONG Baohua, CHEN Qian, QIN Ligang

Subjects
oxidative treatment, myofibrillar proteins, aldehydes, interaction, mechanism, Food processing and manufacture, TP368-456
Abstract

A hydroxyl radical generating system consisting of 0.1 mmol/L FeCl3, 0.1 mmol/L ascorbic acid, and various H2O2 concentrations (0, 0.25, 0.5, 1.0, 2.5, 5, 10 and 25 mmol/L) was established and used to investigate the interaction mechanism of differently oxidized myofibrillar proteins (MPs) with 3-methyl butanal, pentanal, hexanal and heptanal. First, the binding capacity of oxidized MPs to the four aldehydes were determined by gas chromatography-mass spectrometry (GC-MS). Then, ultraviolet (UV) absorption spectroscopy, fluorescence spectroscopy (quenching mechanism and thermodynamic analysis) and circular dichroism (CD) spectroscopy were used to reveal the interaction mechanism between oxidized MPs and aldehydes. The results showed that heptanal had the strongest binding capacity with MPs, and the binding capacity of oxidized MPs with a H2O2 concentration of 1.0 mmol/L to all four aldehydes was the highest (P < 0.05). UV absorption spectra and fluorescence spectra demonstrated that oxidized MPs interacted with the four aldehydes via static and dynamic quenching. The maximum absorption peaks of both tyrosine and tryptophan residues were red-shifted with an increase in heptanal concentration, indicating that the tyrosine and tryptophan residues of MPs were exposed to a more hydrophilic environment. Thermodynamic analysis showed that the interaction between MPs and heptanal was mainly driven by hydrophobic interaction. The CD spectra showed that the α-helix content decreased from 19.24% to 16.88% (P < 0.05) and the β-sheet content increased from 24.59% to 26.47% (P < 0.05) with increasing heptanal concentration, and the structure of MPs changed from the ordered to the disordered state. This study provides a theoretical basis for flavor regulation of meat products.

Published
2023
Full Text
View/download PDF

19. Gene-specific ACMG/AMP classification criteria for germline APC variants: Recommendations from the ClinGen InSiGHT Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel

Author

Spier, Isabel, Yin, Xiaoyu, Richardson, Marcy, Pineda, Marta, Laner, Andreas, Ritter, Deborah, Boyle, Julie, Mur, Pilar, Hansen, Thomas v O., Shi, Xuemei, Mahmood, Khalid, Plazzer, John-Paul, Ognedal, Elisabet, Nordling, Margareta, Farrington, Susan M., Yamamoto, Gou, Baert-Desurmont, Stéphanie, Martins, Alexandra, Borras, Ester, Tops, Carli, Webb, Erica, Beshay, Victoria, Genuardi, Maurizio, Pesaran, Tina, Capellá, Gabriel, Tavtigian, Sean V., Latchford, Andrew, Frayling, Ian M., Plon, Sharon E., Greenblatt, Marc, Macrae, Finlay A., and Aretz, Stefan

Published
2024
Full Text
View/download PDF

21. Construction of Electricity Load Forecasting Model Based on Electricity Data Analysis

Author

He Yue, Zhang Zhi, Chang Yongjuan, Lu Yanyan, and Yin Xiaoyu

Subjects
time series, power load forecasting, power data, time series decomposition-rnn, 68p30, Mathematics, QA1-939
Abstract

This paper builds a time series prediction model of recurrent neural networks based on time series electricity load forecasting. In this paper, the household electricity consumption record data of some residents in urban area S is taken as the research object, and the laws and characteristics of users’ electricity consumption behavior are analyzed in depth based on the real residential electricity consumption data. External factors such as temperature conditions, holidays, etc. The arithmetic cases are also analyzed using real load data sets. In the short-term continuous electricity data analysis, the smaller the time interval is, the closer its corresponding electricity consumption ratio is to 1. There is a negative correlation between long-term continuous electricity consumption. When the temperature is 30~35oC versus -5~0oC, electricity consumption rises significantly. Comparing and analyzing the time series decomposition-RNN with several models, the time series decomposition-RNN model has the highest fit at 10:00-12:00 and 12:00-14:00, and the result verifies the validity of the model proposed in this paper.

Published
2024
Full Text
View/download PDF

31. Neural Machine Translating from Natural Language to SPARQL

Author

Yin, Xiaoyu, Gromann, Dagmar, and Rudolph, Sebastian

Subjects
Computer Science - Computation and Language
Abstract

SPARQL is a highly powerful query language for an ever-growing number of Linked Data resources and Knowledge Graphs. Using it requires a certain familiarity with the entities in the domain to be queried as well as expertise in the language's syntax and semantics, none of which average human web users can be assumed to possess. To overcome this limitation, automatically translating natural language questions to SPARQL queries has been a vibrant field of research. However, to this date, the vast success of deep learning methods has not yet been fully propagated to this research problem. This paper contributes to filling this gap by evaluating the utilization of eight different Neural Machine Translation (NMT) models for the task of translating from natural language to the structured query language SPARQL. While highlighting the importance of high-quantity and high-quality datasets, the results show a dominance of a CNN-based architecture with a BLEU score of up to 98 and accuracy of up to 94%.

Published
2019

32. Zanidatamab for HER2-amplified, unresectable, locally advanced or metastatic biliary tract cancer (HERIZON-BTC-01): a multicentre, single-arm, phase 2b study

Author

Abou-Alfa, Ghassan, Alfonso, Jorge Adeva, Aglietta, Massimo, Baron, Ari, Beg, Muhammad, Aguirre, Paula Carrasco, Chen, Eric, Cheng, Ying, Gracián, Antonio Cubillo, Dahan, Laetitia, De Braud, Filippo, Fenocchio, Elisabetta, Gbolohon, Olumide, Gillmore, Roopinder, Jary, Marine, Javle, Milind, Jiang, Yixing, Kang, Jung Hun, King, Gentry George, Kundranda, Madappa, Layos, Laura, Li, Daneng, Liang, Tingbo, Lonardi, Sara, Marathe, Omkar, Mondaca, Sebastian, Martin, Andrés J. Muñoz, Park, Joon Oh, Pazo Cid, Roberto, Fernandez, Paula Ribera, Rimassa, Lorenza, Alonso, Rosa Rodriguez, Sadeghi, Saeed, Scott, Aaron, Tan, Benjamin, Tougeron, David, Yan, Qiang, Yin, Xiaoyu, Zhao, Haitao, Harding, James J, Fan, Jia, Oh, Do-Youn, Choi, Hye Jin, Kim, Jin Won, Chang, Heung-Moon, Bao, Lequn, Sun, Hui-Chuan, Macarulla, Teresa, Xie, Feng, Metges, Jean-Phillippe, Ying, Jie'er, Bridgewater, John, Lee, Myung-Ah, Tejani, Mohamedtaki A, Chen, Emerson Y, Kim, Dong Uk, Wasan, Harpreet, Ducreux, Michel, Bao, Yuanyuan, Boyken, Lisa, Ma, Jiafang, Garfin, Phillip, and Pant, Shubham

Published
2023
Full Text
View/download PDF

46. Analyzing Amylin Aggregation Inhibition Through Quantum Dot Fluorescence Imaging.

Author

Yin, Xiaoyu, Liu, Ziwei, Huanood, Gegentuya, Sawatari, Hayate, Shimamori, Keiya, Kuragano, Masahiro, and Tokuraku, Kiyotaka

Subjects
*ROSMARINIC acid, *AMYLIN, *TYPE 2 diabetes, *TRANSMISSION electron microscopy, *QUANTUM dots
Abstract

Protein aggregation is associated with various diseases caused by protein misfolding. Among them, amylin deposition is a prominent feature of type 2 diabetes. At present, the mechanism of amylin aggregation remains unclear, and this has hindered the treatment of type 2 diabetes. In this study, we analyzed the aggregation process of amylin using the quantum dot (QD) imaging method. QD fluorescence imaging revealed that in the presence of 100 μM amylin, aggregates appeared after 12 h of incubation, while a large number of aggregates formed after 24 h of incubation, with a standard deviation (SD) value of 5.435. In contrast, 50 μM amylin did not induce the formation of aggregates after 12 h of incubation, although a large number of aggregates were observed after 24 h of incubation, with an SD value of 2.883. Confocal laser microscopy observations revealed that these aggregates were deposited in three dimensions. Transmission electron microscopy revealed that amylin existed as misfolded fibrils in vitro and that QDs were uniformly bound to the amylin fibrils. In addition, using a microliter-scale high-throughput screening (MSHTS) system, we found that rosmarinic acid, a polyphenol, inhibited amylin aggregation at a half-maximal effective concentration of 852.8 μM. These results demonstrate that the MSHTS system is a powerful tool for evaluating the inhibitory activity of amylin aggregation. Our findings will contribute to the understanding of the pathogenesis of amylin-related diseases and the discovery of compounds that may be useful in the treatment and prevention of these diseases. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

47. Leading Systemwide Improvement in Elementary Science Education: Managing Dilemmas of Education System Building.

Author

Seeber, Emily Rose, Spillane, James P., Yin, Xiaoyu, Haverly, Christa, and Quan, Weiyu

Subjects
INDUSTRIALIZED building, SCIENCE education, INSTRUCTIONAL systems, EDUCATIONAL change, TEACHING aids
Abstract

Reforming instruction is challenging. In this comparative case study of 12 school districts, we investigated the dilemmas that emerged for system leaders as they engaged in system building for elementary science and the approaches leaders took in managing them. We found that system leaders' efforts to manage their environments contributed to the preferential treatment of literacy and mathematics relative to science. Leaders managed this dilemma using three strategies: (a) integration of science with other subjects, (b) specialization of teachers, and (c) adopting curriculum materials. This study contributes to literature on dilemma management by showing that dilemmas in education system building are school-subject sensitive, emerge in relation to system building for other subjects, and are embedded in school and education systems' structural/organizational arrangements. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

48. Pd‐Catalyzed Dienylation of Propargylic Esters Enabling Highly Stereoselective Synthesis of Danishefsky‐Type Trisubstituted Dienes.

Author

Zhou, Chen, Dai, Mengfu, Yin, Xiaoyu, Zhang, Mingyue, Gu, Weijin, and Chen, Liang‐An

Abstract

Comprehensive Summary: The stereochemical synthesis of highly substituted Danishefsky‐type dienes remains unsolved in organic chemistry. We describe a simple and efficient approach for the stereoselective synthesis of Danishefsky‐type trisubstituted dienes from readily available propargylic esters via Pd‐catalyzed dienylation reaction through the key intermediate metallacyclobutene in a regio‐, chemo‐ and stereoselective fashion. This method facilitates a broad range of challenging trisubstituted dienes with a high level of stereocontrol. The synthetic utilities of oxygenated trisubstituted dienes have been demonstrated by the downstream chemistry, which notably undergoes Diels‐Alder reaction with a variety of electron‐deficient dienophiles to furnish multisubstituted cyclohexenes in good yields with excellent stereoselectivity. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

49. Mismatch repair gene specifications to the ACMG/AMP classification criteria: Consensus recommendations from the InSiGHT ClinGen Hereditary Colorectal Cancer / Polyposis Variant Curation Expert Panel

Author

Plazzer, John Paul, primary, Macrae, Finlay, additional, Yin, Xiaoyu, additional, Thompson, Bryony A, additional, Farrington, Susan M, additional, Currie, Lauren, additional, Lagerstedt-Robinson, Kristina, additional, Frederiksen, Jane Hubertz, additional, van Overeem Hansen, Thomas, additional, Graversen, Lise, additional, Frayling, Ian M, additional, Akagi, Kiwamu, additional, Yamamoto, Gou, additional, Al-Mulla, Fahd, additional, Ferber, Matthew J, additional, Martins, Alexandra, additional, Genuardi, Maurizio, additional, Kohonen-Corish, Maija, additional, Baert-Desurmont, Stephanie, additional, Spurdle, Amanda B, additional, Capella, Gabriel, additional, Pineda, Marta, additional, Woods, Michael O, additional, Rasmussen, Lene Juel, additional, Heinen, Christopher D, additional, Scott, Rodney J, additional, Tops, Carli M, additional, Greenblatt, Marc S, additional, Dominguez-Valentin, Mev, additional, Ognedal, Elisabet, additional, Borras, Ester, additional, Leung, Suet Y, additional, Mahmood, Khalid, additional, Holinski-Feder, Elke, additional, and Laner, Andreas, additional

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results