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1. A Coronary-Friendly Device Mitigating Risk of Coronary Obstruction in Transcatheter Aortic Valve Replacement

Author: Lu Y, Yin M, Yang Y, Wang W, Dong L, Yang X, Wang C, Wang X, Chen J, and Wei L
Subjects: tavr, coronary artery obstruction, aortic regurgitation, aortic stenosis, structural heart disease, Geriatrics, RC952-954.6
Abstract: Yuntao Lu,1,2,&ast; Minyan Yin,3,4,&ast; Ye Yang,1,2,&ast; Wenshuo Wang,1,2 Lili Dong,5 Xue Yang,3,4 Chunsheng Wang,1,2 Xiaolin Wang,3,4 Jinmiao Chen,1,2 Lai Wei1,2 1Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Shanghai Engineering Research Center of Heart Valve, Shanghai, People’s Republic of China; 3Shanghai Institute of Medical Imaging, Shanghai, People’s Republic of China; 4Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 5Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lai Wei; Jinmiao Chen, Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China, Tel +86 021 64041990, Email wei.lai@zs-hospital.sh.cn; chen.jinmiao@zs-hospital.sh.cnPurpose: Transcatheter aortic valve replacement (TAVR) induced coronary artery obstruction (CAO) is a rare but devastating complication. Current preventive strategies need additional procedures and may be associated with adverse events. This study aimed to evaluate the early safety and efficacy of stand-alone TAVR using the J-Valve (Jianshi JieCheng Medical Technology Co. Ltd, Shanghai, China) in patients at potential high risk for CAO.Patients and Methods: CAO was defined as coronary ostia obstruction requiring intervention. Patients at potential high risk for CAO were identified retrospectively from 673 consecutive patients who underwent TAVR from January 2015 to July 2021 at Zhongshan Hospital, Fudan University. Procedural results and early outcomes were evaluated according to Valve Academic Research Consortium-3 definitions.Results: A total of 20 consecutive patients (age 72 ± 9 years; 85% female;) were included. The Society of Thoracic Surgeons-Predicted Risk of Mortality was 5% (interquartile range, 4 to 10%). All patients (100%) had at least 2 classical risk factors for CAO by pre-procedural computed tomography analysis, and 90% patients had native aortic valve diseases. TAVR was successful in 95% of cases, with only 1 patient requiring second device implantation. Early safety at 30 days was achieved in all cases without death. All patients were free from CAO, stroke or emergency reintervention. Post-procedural mean aortic valve gradient was 7 (interquartile range, 4, 12) mmHg, and none/trace or mild aortic regurgitation was present in all patients.Conclusion: Stand-alone TAVR using the J-Valve may mitigate the risk of TAVR-induced CAO. Keywords: TAVR, coronary artery obstruction, aortic regurgitation, aortic stenosis, structural heart disease
Published: 2024

2. Source-Free Domain Adaptation for Question Answering with Masked Self-training

Author: Yin, M., Wang, B., Dong, Y., and Ling, C.
Subjects: Computer Science - Computation and Language
Abstract: Most previous unsupervised domain adaptation (UDA) methods for question answering(QA) require access to source domain data while fine-tuning the model for the target domain. Source domain data may, however, contain sensitive information and may be restricted. In this study, we investigate a more challenging setting, source-free UDA, in which we have only the pretrained source model and target domain data, without access to source domain data. We propose a novel self-training approach to QA models that integrates a unique mask module for domain adaptation. The mask is auto-adjusted to extract key domain knowledge while trained on the source domain. To maintain previously learned domain knowledge, certain mask weights are frozen during adaptation, while other weights are adjusted to mitigate domain shifts with pseudo-labeled samples generated in the target domain. %As part of the self-training process, we generate pseudo-labeled samples in the target domain based on models trained in the source domain. Our empirical results on four benchmark datasets suggest that our approach significantly enhances the performance of pretrained QA models on the target domain, and even outperforms models that have access to the source data during adaptation.
Published: 2022

3. ULK1 Mediated Autophagy-Promoting Effects of Rutin-Loaded Chitosan Nanoparticles Contribute to the Activation of NF-κB Signaling Besides Inhibiting EMT in Hep3B Hepatoma Cells

Author: Wu P, Wang X, Yin M, Zhu W, Chen Z, Zhang Y, Jiang Z, Shi L, and Zhu Q
Subjects: rcnps, hep3b, ros, qpcr, mechanism., Medicine (General), R5-920
Abstract: Peng Wu,1,&ast; Xiaoyong Wang,2,&ast; Min Yin,1,&ast; Wenjie Zhu,3,&ast; Zheng Chen,1 Yang Zhang,1 Ziyu Jiang,4 Longqing Shi,5 Qiang Zhu1 1Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 2The People’s Hospital of Rugao, Nantong, People’s Republic of China; 3Kangda College of Nanjing Medical University, Nanjing, People’s Republic of China; 4Department of Oncology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, People’s Republic of China; 5Department of Hepatobiliary and Pancreatic Surgery, Third Affiliated Hospital of Soochow University, Jiangsu, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Longqing Shi, Department of Hepatobiliary and Pancreatic Surgery, The Third Affiliated Hospital of Soochow University, Jiangsu, People’s Republic of China, Email 20204135017@stu.suda.edu.cn Qiang Zhu, Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China, Email zhu20081023@yeah.netBackground: Liver cancer remains to be one of the leading causes of cancer worldwide. The treatment options face several challenges and nanomaterials have proven to improve the bioavailability of several drug candidates and their applications in nanomedicine. Specifically, chitosan nanoparticles (CNPs) are extremely biodegradable, pose enhanced biocompatibility and are considered safe for use in medicine.Methods: CNPs were synthesized by ionic gelation, loaded with rutin (rCNPs) and characterized by ultraviolet–visible spectroscopy (UV-Vis), Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The rCNPs were tested for their cytotoxic effects on human hepatoma Hep3B cells, and experiments were conducted to determine the mechanism of such effects. Further, the biocompatibility of the rCNPs was tested on L929 fibroblasts, and their hemocompatibility was determined.Results: Initially, UV–vis and FTIR analyses indicated the possible loading of rutin on rCNPs. Further, the rutin load was quantitatively measured using Ultra-Performance Liquid Chromatography (UPLC) and the concentration was 88 μg/mL for 0.22 micron filtered rCNPs. The drug loading capacity (LC%) of the rCNPs was observed to be 13.29 ± 0.68%, and encapsulation efficiency (EE%) was 19.55 ± 1.01%. The drug release was pH-responsive as 88.58% of the drug was released after 24 hrs at the lysosomal pH 5.5, whereas 91.44% of the drug was released at physiological pH 7.4 after 102 hrs. The cytotoxic effects were prominent in 0.22 micron filtered samples of 5 mg/mL rutin precursor. The particle size for the rCNPs at this concentration was 144.1 nm and the polydispersity index (PDI) was 0.244, which is deemed to be ideal for tumor targeting. A zeta potential (ζ-potential) value of 16.4 mV indicated rCNPs with good stability. The IC50 value for the cytotoxic effects of rCNPs on human hepatoma Hep3B cells was 9.7 ± 0.19 μg/mL of rutin load. In addition, the increased production of reactive oxygen species (ROS) and changes in mitochondrial membrane potential (MMP) were observed. Gene expression studies indicated that the mechanism for cytotoxic effects of rCNPs on Hep3B cells was due to the activation of Unc-51-like autophagy-activating kinase (ULK1) mediated autophagy and nuclear factor kappa B (NF-κB) signaling besides inhibiting the epithelial–mesenchymal Transition (EMT). In addition, the rCNPs were less toxic on NCTC clone 929 (L929) fibroblasts in comparison to the Hep3B cells and possessed excellent hemocompatibility (less than 2% of hemolysis).Conclusion: The synthesized rCNPs were pH-responsive and possessed the physicochemical properties suitable for tumor targeting. The particles were effectively cytotoxic on Hep3B cells in comparison to normal cells and possessed excellent hemocompatibility. The very low hemolytic profile of rCNPs indicates that the drug could be administered intravenously for cancer therapy.Keywords: rCNPs, Hep3B, ROS, qPCR, mechanism
Published: 2024

4. A China-Based Cost-Effectiveness Analysis of Novel Oral Anticoagulants versus Warfarin in Patients with Left Ventricular Thrombosis

Author: Tian S, Zhong H, Yin M, Jiang P, and Liu Q
Subjects: cost-effectiveness, novel oral anticoagulants, left ventricular thrombosis, thrombus resolution, Public aspects of medicine, RA1-1270
Abstract: Shuo Tian,1,2,&ast; Haitao Zhong,3,4,&ast; Mengyue Yin,5 Pei Jiang,3 Qiao Liu1 1Department of Pharmacy, The Second Xiangya Hospital of Central South University, Central South University, Changsha, Hunan, People’s Republic of China; 2Department of Clinical Pharmacy, Jining First People’s Hospital, Shandong First Medical University, Jining, Shandong, People’s Republic of China; 3Translational Pharmaceutical Laboratory, Jining First People’s Hospital, Shandong First Medical University, Jining, Shandong, People’s Republic of China; 4Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, Shandong, People’s Republic of China; 5The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qiao Liu, Department of Pharmacy, The Second Xiangya Hospital of Central South University, Central South University, Changsha, Hunan, People’s Republic of China, Email liuqiao6767@csu.edu.cnPurpose: This study aims to conduct a comprehensive cost-effectiveness comparison between novel oral anticoagulants (NOACs) and warfarin in Chinese patients with left ventricular thrombosis (LVT). By incorporating the impact of volume-based procurement (VBP) policy for pharmaceuticals in China, this analysis intends to provide crucial insights for informed healthcare decision-making.Patients and Methods: A Markov model was employed to simulate the disease progression of LVT over a 54-week time horizon, using weekly cycles and six mutually exclusive health states. The model incorporated transition probabilities between health states calculated based on clinical trial data and literature sources. Various cost and utility parameters were also included. Additionally, a series of sensitivity analyses were conducted to address parameter variations and associated uncertainties.Results: The study finding suggest that from the perspective of Chinese healthcare, the majority of brand-name drug (BND) NOACs generally lack cost-effectiveness when compared to warfarin. However, when considered the VBP policy, NOACs, particularly rivaroxaban, prove to be more cost-effective than warfarin. Rivaroxaban provided an additional 0.0304 quality-adjusted life years (QALYs) per patient and reduced overall medical costs by 9095.73 CNY, resulting in an incremental cost-effectiveness ratio (ICER) of − 298,786.20 CNY/QALY. Sensitivity analysis indicated a 78.4% probability of any NOACs being more cost-effective compared to warfarin. However, specifically considering NOACs under the VBP policy, the likelihood of them being more cost-effective approached 90%.Conclusion: Taking into account Chinese pharmaceutical procurement policies, the findings highlight the superior efficacy of NOACs, especially rivaroxaban, in enhancing both the quality of life and economic benefits for Chinese LVT patients. NOACs present a more cost-effective treatment option, improving patient quality of life and healthcare cost efficiency compared to warfarin.Keywords: cost-effectiveness, novel oral anticoagulants, left ventricular thrombosis, thrombus resolution
Published: 2024

5. Wraparound Services Needs Assessment: Campus Needs Assessment Findings, Fall 2019 Survey

Author: Rice University, Houston Education Research Consortium (HERC), Stroub, K., Yin, M., and Cigarroa Kennedy, C.
Abstract: The Wraparound Services Department connects students and their families with non-academic community resources that support the students' ability to learn in school. The district currently partners with over 200 community organizations to offer wraparound services across 210 campuses. Wraparound Services Specialists in these campuses work with various organizations to address student and family needs within the domains of mental and physical health, food and housing insecurity, home and neighborhood safety, and out-of-school educational needs. With support from the Houston Endowment and the City of Houston, Houston Independent School District (HISD) has recently committed to expanding its Wraparound Services Program. Dubbed the "Supporting Students, Uplifting Communities" initiative, HISD seeks to increase the number of Wraparound Services Specialists from 210 to 280, ensuring that every campus in the district has at least one dedicated full-time specialist by the 2021-22 school year. Additionally, to better align the services that wraparound specialists have available to them with student and family needs, the district created and administered the first annual Needs Assessment Survey in Fall 2019. The survey was administered to students, parents, and teachers at existing wraparound campuses. In total, 51,769 students, 5,305 parents, and 4,698 teachers completed the survey. The survey asked respondents to identify non-academic needs across five key domains: (1) health, dental, and hygiene needs; (2) emotional and psychological needs, (3) home and family needs, (4) educational and vocational needs, and (5) social and recreational need. The purpose of this brief is to provide an overview of how campus needs vary by neighborhood location and campus characteristics. This brief is divided into five sections: (1) Section I explores how the needs of students vary by campus characteristics (economic disadvantage, limited English proficiency, and special education); (2) Section II compares the needs at Achieve 180 campuses to the needs at non-Achieve 180 campuses; (3) Section III presents maps illustrating the geographic distribution of high need campuses across HISD; (4) Section IV provides tables ranking all current wraparound campuses by their level of need; and (5) Section V highlights the five highest need campuses for each question asked on the survey. [For related reports see, "Wraparound Services Needs Assessment: District-Wide Needs Assessment Findings, Fall 2019" (ED611196) and "Wraparound Needs in HISD: Findings from the District's 2019 Needs Assessment Survey" (ED611190).]
Published: 2021

6. Wraparound Services Needs Assessment: District-Wide Needs Assessment Findings, Fall 2019

Author: Rice University, Houston Education Research Consortium (HERC), Stroub, K., Yin, M., and Cigarroa Kennedy, C.
Abstract: The Wraparound Services Department connects students and their families with non-academic community resources that support the students' ability to learn in school. The district currently partners with over 200 community organizations to offer wraparound services across 210 campuses. Wraparound Services Specialists in these campuses work with various organizations to address student and family needs within the domains of mental and physical health, food and housing insecurity, home and neighborhood safety, and out-of-school educational needs. With support from the Houston Endowment and the City of Houston, Houston Independent School District (HISD) has recently committed to expanding its Wraparound Services Program. Dubbed the "Supporting Students, Uplifting Communities" initiative, HISD seeks to increase the number of Wraparound Services Specialists from 210 to 280, ensuring that every campus in the district has at least one dedicated full-time specialist by the 2021-22 school year. Additionally, to better align the services that wraparound specialists have available to them with student and family needs, the district created and administered the first annual Needs Assessment Survey in Fall 2019. The survey was administered to students, parents, and teachers at existing wraparound campuses. In total, 51,769 students, 5,305 parents, and 4,698 teachers completed the survey. The survey asked respondents to identify non-academic needs across five key domains: (1) health, dental, and hygiene needs; (2) emotional and psychological needs; (3) home and family needs; (4) educational and vocational needs; and (5) social and recreational needs. The purpose of this brief is to provide an overview of the key areas of need that students, parents, and teachers reported across the five survey domains. In this brief, survey findings are reported for the district overall. [For related reports see "Wraparound Services Needs Assessment: Campus Needs Assessment Findings, Fall 2019 Survey" (ED611195) and "Wraparound Needs in HISD: Findings from the District's 2019 Needs Assessment Survey" (ED611190).]
Published: 2021

7. Clinical Application of an Artificial Intelligence System for Diagnosing Thyroid Disease Based on a Computer Neural Network Deep Learning Model

Author: Li Z, Yin M, and Li W
Subjects: artificial intelligence-aided diagnosis software, computer neural network deep learning model, thyroid nodules, Medicine (General), R5-920
Abstract: Zhihai Li,1 Meilin Yin,2 Wenfeng Li3 1Department of Ultrasound, Dalang Hospital, Dongguan, Guandong, People’s Republic of China; 2Department of Science and Education, Dalang Hospital, Dongguan, Guandong, People’s Republic of China; 3Department of Intervention, Dalang Hospital, Dongguan, Guandong, People’s Republic of ChinaCorrespondence: Zhihai Li, Department of Ultrasound, Dalang Hospital, No. 85 Jinlang Middle Road, Dalang Town, Dongguan, Guandong, 523777, People’s Republic of China, Tel +86 18928276466, Email zhilelidr123@outlook.comPurpose: This study aimed to establish a stereoscopic neural learning network through deep learning and construct an artificial intelligence (AI) diagnosis system for the prediction of benign and malignant thyroid diseases, as well as repeatedly verified the diagnosis system and adjusted the data, in order to develop a type of AI-assisted thyroid diagnosis software with a low false negative rate and high sensitivity for clinical practice.Patients and Methods: From July 2020 to April 2023, A total of 36 patients with thyroid nodules in our hospital were selected for diagnosis of thyroid nodules based on the Expert Consensus on Thyroid Ultrasound; samples were taken by aspiration biopsy or surgically and sent for pathological diagnosis. The ultrasonic diagnosis results were compared with the pathological results, a database was established based on the ultrasonic diagnostic characteristics and was entered in the AI-assisted diagnosis software for judgment of benign and malignant conditions. The data in the software were corrected based on the conformity rate and the reasons for misjudgment, and the corrected software was used to evaluate the benign and malignant conditions of the 36 patients, until the conformity rate exceeded 90%.Results: The initial conformity rate of the AI software for identifying benign and malignant conditions was 88%, while that of the software utilizing the database was 94%.Conclusion: We established a stereoscopic neural learning network and construct an AI diagnosis system for the prediction of benign and malignant thyroid diseases, with a low false negative rate and high sensitivity for clinical practice.Keywords: artificial intelligence-aided diagnosis software, computer neural network deep learning model, thyroid nodules
Published: 2024

8. Determining the lower limit of detection required for HCV viral load assay for test of cure following direct‐acting antiviral‐based treatment regimens: Evidence from a global data set

Author: Morgan, Jake R, Marsh, Elizabeth, Savinkina, Alexandra, Shilton, Sonjelle, Shadaker, Shaun, Tsertsvadze, Tengiz, Kamkamidze, George, Alkhazashvili, Maia, Morgan, Timothy, Belperio, Pam, Backus, Lisa, Doss, Waheed, Esmat, Gamal, Hassany, Mohamed, Elsharkawy, Aisha, Elakel, Wafaa, Mehrez, Mai, Foster, Graham R, Kinge, Constance Wose, Chew, Kara W, Chasela, Charles S, Sanne, Ian M, Thanung, Yin M, Loarec, Anne, Aslam, Khawar, Balkan, Suna, Easterbrook, Philippa J, and Linas, Benjamin P
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Hepatitis - C, Liver Disease, Emerging Infectious Diseases, Digestive Diseases, Infectious Diseases, Hepatitis, Chronic Liver Disease and Cirrhosis, Clinical Research, Infection, Good Health and Well Being, Antiviral Agents, Female, Genotype, Hepacivirus, Hepatitis C, Hepatitis C, Chronic, Humans, Limit of Detection, Male, RNA, Viral, Sustained Virologic Response, Treatment Outcome, Viral Load, Viremia, diagnostics, HCV, limit of detection, point-of-care testing, Microbiology, Medical Microbiology, Gastroenterology & Hepatology, Clinical sciences, Medical microbiology
Abstract: Achieving global elimination of hepatitis C virus requires a substantial scale-up of testing. Point-of-care HCV viral load assays are available as an alternative to laboratory-based assays to promote access in hard to reach or marginalized populations. The diagnostic performance and lower limit of detection are important attributes of these new assays for both diagnosis and test of cure. Therefore, our objective was to determine an acceptable LLoD for detectable HCV viraemia as a test for cure, 12 weeks post-treatment (SVR12). We assembled a global data set of patients with detectable viraemia at SVR12 from observational databases from 9 countries (Egypt, the United States, United Kingdom, Georgia, Ukraine, Myanmar, Cambodia, Pakistan, Mozambique) and two pharmaceutical-sponsored clinical trial registries. We examined the distribution of HCV viral load at SVR12 and presented the 90th, 95th, 97th and 99th percentiles. We used logistic regression to assess characteristics associated with low-level virological treatment failure (defined as
Published: 2022

9. Intravoxel incoherent motion diffusion-weighted imaging of solitary pulmonary lesions: initial study with gradient- and spin-echo sequences

Author: Yin, M., Cao, Guanjie, Lv, S., Sun, Z., Li, M., Wang, H., and Yue, X.
Published: 2024
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10. Diversity and Community Structure of Arbuscular Mycorrhizal Fungi (AMF) in the Rhizospheric Soil of Panax notoginseng in Different Ages

Author: Pei, Y., Yin, M., Li, Q. H., Zhang, Y. F., Zhong, Y., Chen, X., Zhang, Y. P., Huang, B., and Ren, Z.
Published: 2023
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11. Fibroblast Growth Factor 11 (FGF11) Promotes Progression and Cisplatin Resistance Through the HIF-1α/FGF11 Signaling Axis in Ovarian Clear Cell Carcinoma

Author: Yin M, Lu C, Zhou H, Liu Q, and Yang J
Subjects: ovarian clear cell carcinoma, cisplatin chemoresistance, fgf11, hif-1α, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Min Yin,1,&ast; Chunli Lu,2,&ast; Huimei Zhou,1 Qian Liu,1 Jiaxin Yang1 1National Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 2Neurospine Center, China International Neuroscience Institute (CHINA-INI), Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Huimei Zhou; Jiaxin Yang, Email zhmpumch@126.com; yjxpumch@163.comBackground: A poor prognosis is often associated with ovarian clear cell carcinoma (OCCC) due to its relative resistance to platinum-based chemotherapy. Although several studies have been launched to explore the pathogenesis of OCCC, the mechanism of chemoresistance has yet to be uncovered.Methods: Nanostring nCounter PanCancer Pathways Panel was performed to explore the expression profiles of OCCC tissues from patients showing different platinum sensitivity. Bioinformatic analysis was performed to select genes associated with chemoresistance and cell function assays, including colony formation, wound healing, transwell and flow cytometric analysis, were used to explore the role of the target gene in the progression of OCCC and resistance to cisplatin (DDP).Results: Gene expression profiles and bioinformatic analysis verified that the expression of fibroblast growth factor 11 (FGF11) was significantly increased in platinum-resistant OCCC tissues and increased FGF11 expression was related to poorer survival. Downregulation of FGF11 inhibited the proliferation, migration, and invasion, reversing the DDP resistance of OCCC cells. Mechanically, FGF11 was regulated by hypoxia-inducible factor-1α (HIF-1α) to modulate the DDP sensitivity.Conclusion: FGF11 was highly expressed in platinum-resistant OCCC tissues, promoting progression and resistance to DDP through the HIF-1α/FGF11 signaling axis.Keywords: ovarian clear cell carcinoma, cisplatin chemoresistance, FGF11, HIF-1&#x03B1
Published: 2023

12. Diagnosis of spinal dural arteriovenous fistula: a multimodal MRI assessment strategy

Author: Ouyang, F., Wu, Q., Duan, B., Yuan, X., Wang, B., Chen, Y., Yin, M., and Zeng, X.
Published: 2023
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13. An experimental proof that resistance-switching memories are not memristors

Author: Kim, J., Pershin, Y. V., Yin, M., Datta, T., and Di Ventra, M.
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Computer Science - Emerging Technologies
Abstract: It has been suggested that all resistive-switching memory cells are memristors. The latter are hypothetical, ideal devices whose resistance, as originally formulated, depends only on the net charge that traverses them. Recently, an unambiguous test has been proposed [J. Phys. D: Appl. Phys. {\bf 52}, 01LT01 (2019)] to determine whether a given physical system is indeed a memristor or not. Here, we experimentally apply such a test to both in-house fabricated Cu-SiO2 and commercially available electrochemical metallization cells. Our results unambiguously show that electrochemical metallization memory cells are not memristors. Since the particular resistance-switching memories employed in our study share similar features with many other memory cells, our findings refute the claim that all resistance-switching memories are memristors. They also cast doubts on the existence of ideal memristors as actual physical devices that can be fabricated experimentally. Our results then lead us to formulate two memristor impossibility conjectures regarding the impossibility of building a model of physical resistance-switching memories based on the memristor model.
Published: 2019
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14. Research progress on gels-based nanocomposites in the diagnostics and therapy of prostate diseases

Author: Zhong, R., Chu, R., Zhu, J., Ling, J., Zhang, L., Zhou, Y., Yin, M., Hao, Z., Liang, C., Cao, S., Xu, T., Ye, S., and Fan, S.
Published: 2023
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15. Mobility Hierarchy and Simulation of a Modular, Reconfigurable, Tetrahedral Robot System

Author: Chen, Yin M., Englot, Brendan, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Kim, Jinwhan, editor, Englot, Brendan, editor, Park, Hae-Won, editor, Choi, Han-Lim, editor, Myung, Hyun, editor, Kim, Junmo, editor, and Kim, Jong-Hwan, editor
Published: 2022
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16. GARP Polymorphisms Associated with Susceptibility to House Dust Mite-Sensitized Persistent Allergic Rhinitis in a Chinese Population

Author: Chen XY, Zhu XJ, Chen M, Lu MP, Wang ML, Yin M, Chen RX, Wu ZF, Bu DY, Zhang ZD, and Cheng L
Subjects: allergic rhinitis, mites, garp, lrrc32, single nucleotide polymorphism, genetic association studies, Immunologic diseases. Allergy, RC581-607
Abstract: Xin-Yuan Chen,1,&ast; Xin-Jie Zhu,1,&ast; Min Chen,1 Mei-Ping Lu,1 Mei-Lin Wang,2,3 Min Yin,1,4 Ruo-Xi Chen,1 Zhong-Fei Wu,1 Dong-Yun Bu,1 Zheng-Dong Zhang,2,3 Lei Cheng1,4 1Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China; 3Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China; 4International Centre for Allergy Research, Nanjing Medical University, Nanjing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lei Cheng, Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People’s Republic of China, Email chenglei@jsph.org.cn Zheng-Dong Zhang, Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, People’s Republic of China, Email drzdzhang@njmu.edu.cnBackground: Genetic variants in GARP (also known as LRRC32) have been reported to have significant associations with asthma and eczema in special populations, but little is known about allergic rhinitis. This study purposes to evaluate the association of single nucleotide polymorphisms (SNPs) in GARP with house dust mite (HDM)-sensitized persistent allergic rhinitis (PER) in a population of Han Chinese.Methods: In this hospital-based case–control study, 534 HDM-sensitized PER patients and 451 healthy controls were recruited from East China. In this population, six SNPs in GARP were identified. Serum total and specific IgE levels were measured with ImmunoCAP. Secondary structure and minimum free energy were predicted by RNAfold.Results: rs79525962 was associated with the risk of HDM-sensitized PER (P < 0.05). The individuals with CT+TT genotype demonstrated a higher risk of HDM-sensitized PER than those with CC genotype (adjusted OR = 1.393, 95% CI = 1.019– 1.904). The homozygous genotype CC of rs3781699 rendered a lower risk of HDM-sensitized PER than the wild-type genotype AA (adjusted OR = 0.646, 95% CI = 0.427– 0.976); however, the genotype and allele frequencies of rs3781699 demonstrated no associations with HDM-sensitized PER (P > 0.05). rs79525962 increased the risk of HDM-sensitized PER in the subgroup aged ≥ 16 years (adjusted OR = 1.745, 95% CI = 1.103– 2.760), and this high risk was also found in the females (adjusted OR = 1.708, 95% CI = 1.021– 2.856). The G-C haplotype of rs1320646-rs3781699 rendered a lower risk of HDM-sensitized PER than the common haplotype G-A (adjusted OR = 0.819, 95% CI = 0.676– 0.993). The secondary structure of GARP altered in response to different genotypes of rs79525962 and rs3781699.Conclusion: SNP rs79525962 in the GARP gene marks a risk locus of HDM-sensitized PER in Chinese Hans.Keywords: allergic rhinitis, mites, GARP, LRRC32, single nucleotide polymorphism, genetic association studies
Published: 2022

17. Target-Driven Tissue-Agnostic Drug Approvals; a New Path of Drug Development

Author: Thein, Kyaw Z, primary, Myat, Yin M, additional, Park, Byung S, additional, Panigrahi, Kalpana, additional, and Kummar, Shivaani, additional
Published: 2024
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18. BONE MARROW-DERIVED MESENCHYMAL STEM CELL THERAPY IN CHRONIC KIDNEY DISEASE: AN EARLY PHASE CLINICAL TRIAL

Author: Elhusseiny, K., primary, Alatta, L., additional, Snow, Z.K., additional, Skaff, C., additional, Yin, M., additional, Aslam, N., additional, Porter, I., additional, Mao, M., additional, Trautman, C., additional, Baker, L., additional, Manohar, S., additional, Chebib, F., additional, Lorenz, E., additional, and Hickson, L., additional
Published: 2024
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19. TARGETED LENTIVIRAL TRANSDUCTION USING MICROBUBBLE-BASED ARTIFICIAL VIRUS PRESENTING CELLS

Author: LIU, Y., primary, Yin, M., additional, Kunte, N., additional, Lopez-Ramirez, M., additional, and Shi, G., additional
Published: 2024
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20. Differences in Muscle Quantity and Quality by HIV Serostatus and Sex

Author: Erlandson, Kristine M., Langan, S., Lake, J. E., Sun, J., Sharma, A., Adrian, S., Scherzinger, A., Palella, F., Kingsley, L., Gange, S. J., Tien, P. C., Yin, M. T., and Brown, T. T.
Published: 2022
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21. TLR Signaling Pathway Gene Polymorphisms, Gene–Gene and Gene–Environment Interactions in Allergic Rhinitis

Author: Chen RX, Dai MD, Zhang QZ, Lu MP, Wang ML, Yin M, Zhu XJ, Wu ZF, Zhang ZD, and Cheng L
Subjects: allergic rhinitis, toll-like receptors, cd14, single nucleotide polymorphism, gene-gene interaction, gene-environment interaction., Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Ruo-Xi Chen,1,&ast; Meng-Di Dai,1,&ast; Qing-Zhao Zhang,1 Mei-Ping Lu,1 Mei-Lin Wang,2,3 Min Yin,1,4 Xin-Jie Zhu,1 Zhong-Fei Wu,1 Zheng-Dong Zhang,2,3 Lei Cheng1,4 1Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China; 3Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China; 4International Centre for Allergy Research, Nanjing Medical University, Nanjing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lei Cheng, Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People’s Republic of China, Email chenglei@jsph.org.cn Zheng-Dong Zhang, Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, People’s Republic of China, Email drzdzhang@njmu.edu.cnABSTRACT: Background: Allergic rhinitis (AR) is a nasal inflammatory disease resulting from a complex interplay between genetic and environmental factors. The association between Toll-like receptor (TLR) signaling pathway and environmental factors in AR pathogenesis remains to be explored. This study aims to assess the genetic association of AR with single nucleotide polymorphisms (SNPs) in TLR signaling pathway, and investigate the roles of gene–gene and gene–environment interactions in AR.Methods: A total of 452 AR patients and 495 healthy controls from eastern China were enrolled in this hospital-based case–control study. We evaluated putatively functional genetic polymorphisms in TLR2, TLR4 and CD14 genes for their association with susceptibility to AR and related clinical phenotypes. Interactions between environmental factors (such as traffic pollution, residence, pet keeping) and polymorphisms with AR were examined using logistic regression. Models were stratified by genotype and interaction terms, and tested for the significance of gene–gene and gene–environment interactions.Results: In the single-locus analysis, two SNPs in CD14, rs2563298 (A/C) and rs2569191 (C/T) were associated with a significantly decreased risk of AR. Compared with the GG genotype, the GT and GT/TT genotypes of TLR2 rs7656411 (G/T) were associated with a significantly increased risk of AR. Gene–gene interactions (eg, TLR2 rs7656411, TLR4 rs1927914, and CD14 rs2563298) was associated with AR. Gene–environment interactions (eg, TLR4 or CD14 polymorphisms and certain environmental exposures) were found in AR cases, but they were not significant after Bonferroni correction.Conclusion: The genetic polymorphisms of TLR2 and CD14 and gene–gene interactions in TLR signaling pathway were associated with susceptibility to AR in this Han Chinese population. However, the present results were limited to support the association between gene–environment interactions and AR.Keywords: allergic rhinitis, toll-like receptors, CD14, single nucleotide polymorphism, gene–gene interaction, gene–environment interaction
Published: 2022

22. Mobility Hierarchy and Simulation of a Modular, Reconfigurable, Tetrahedral Robot System.

Author: Yin M. Chen and Brendan J. Englot
Published: 2021
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23. Mobility Hierarchy and Simulation of a Modular, Reconfigurable, Tetrahedral Robot System

Author: Chen, Yin M., primary and Englot, Brendan, additional
Published: 2022
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24. Quantitative measurement of medial femoral knee cartilage volume – analysis of the OA Biomarkers Consortium FNIH Study cohort

Author: Schaefer, LF, Sury, M, Yin, M, Jamieson, S, Donnell, I, Smith, SE, Lynch, JA, Nevitt, MC, and Duryea, J
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Osteoarthritis, Biomedical Imaging, Bioengineering, Pain Research, Clinical Research, Arthritis, Chronic Pain, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Musculoskeletal, Aged, Cartilage, Articular, Case-Control Studies, Disease Progression, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Osteoarthritis, Knee, Risk Factors, Cartilage, Knee, Magnetic resonance imaging, Segmentation software, Biomedical Engineering, Human Movement and Sports Sciences, Arthritis & Rheumatology, Clinical sciences, Sports science and exercise
Abstract: ObjectiveLarge studies of knee osteoarthritis (KOA) require well-characterized efficient methods to assess progression. We previously developed the local-area cartilage segmentation (LACS) software method, to measure cartilage volume on magnetic resonance imaging (MRI) scans. The present study further validates this method in a larger patient cohort and assesses predictive validity in a case-control study.MethodThe OA Biomarkers Consortium FNIH Project, a case-control study of KOA progression nested within the Osteoarthritis Initiative (OAI), includes 600 subjects in four subgroups based on radiographic and pain progression. Our software tool measured change in medial femoral cartilage volume in a central weight-bearing region. Different sized regions of cartilage were assessed to explore their sensitivity to change. The readings were performed on MRI scans at the baseline and 24-month visits. We used standardized response means (SRMs) for responsiveness and logistic regression for predictive validity.ResultsCartilage volume change was associated strongly with radiographic progression (odds ratios (OR) = 4.66; 95% confidence intervals (CI) = 2.85-7.62). OR were significant but of lesser magnitude for the combined radiographic and pain progression outcome (OR = 1.70; 95% CI = 1.40-2.07). For the full 600 subjects, theSRM was -0.51 for the largest segmented area. Smaller areas of cartilage segmentation were also able to predict the case-control status. The average reader time for the largest area was less than 20 min per scan. Smaller areas could be assessed with less reader time.ConclusionWe demonstrated that the LACS method is fast, responsive, and associated with radiographic and pain progression, and is appropriate for existing and future large studies of KOA.
Published: 2017

25. Balancing Time and Energy Efficiency by Sizing Clusters: A New Data Collection Scheme in UAV-Aided Large-Scale Internet of Things

Author: Ma, X, Huang, M, Ni, W, Yin, M, Min, J, Jamalipour, A, Ma, X, Huang, M, Ni, W, Yin, M, Min, J, and Jamalipour, A
Abstract: Unmanned aerial vehicle (UAV)-aided large-scale Internet of Things (UAV-LIoT) are widely used but lack a balanced data collection (DC) scheme. To address this, we propose DC- nonorthogonal multiple access (NOMA), a new DC scheme that combines machine learning clustering with NOMA. We introduce an optimization algorithm for peak density clustering and a new LIoT clustering method. Our approach dynamically adjusts cluster size and formulates the energy-time efficiency problem as a tradeoff between energy minimization and data rate maximization. We propose a heuristic algorithm based on NOMA and an intracluster DC protocol. Experimental results show that DC- NOMA achieves balanced DC time, energy efficiency, load balance, and network lifespan extension, outperforming its benchmarks.
Published: 2024

26. A Complex Gaussian Fuzzy Numbers-Based Multisource Information Fusion for Pattern Classification

Author: Zhang, S, Yin, M, Xiao, F, Cao, Z, Pelusi, D, Zhang, S, Yin, M, Xiao, F, Cao, Z, and Pelusi, D
Abstract: Uncertainty modeling and reasoning in intelligent systems are crucial for effective decision-making, such as complex evidence theory (CET) being particularly promising in dynamic information processing. Within CET, the complex basic belief assignment (CBBA) can model uncertainty accurately, while the complex rule of combination can effectively reason uncertainty with multiple sources of information, reaching a consensus. However, determining CBBA, as the key component of CET, remains an open issue. To mitigate this issue, we propose a novel method for generating CBBA using high-level features extracted from Box-Cox transformation and discrete Fourier transform (DFT). Specifically, our method deploys complex Gaussian fuzzy number (CGFN) to generate CBBA, which provides a more accurate representation of information. The proposed method is applied to pattern classification tasks through a multisource information fusion algorithm, and it is compared with several well-known methods to demonstrate its effectiveness. Experimental results indicate that our proposed CGFN-based method outperforms existing methods, by achieving the highest average classification rate in multisource information fusion for pattern classification tasks. We found the Box-Cox transformation contributes significantly to CGFN by formatting data in a normal distribution, and DFT can effectively extract high-level features. Our method offers a practical approach for generating CBBA in CET, precisely representing uncertainty and enhancing decision-making in uncertain scenarios.
Published: 2024

27. Observation of $\eta^{\prime}\to\omega e^{+} e^{-}$

Author: Ablikim, M., Achasov, M. N., Ai, X. C., Albayrak, O., Albrecht, M., Ambrose, D. J., Amoroso, A., An, F. F., An, Q., Bai, J. Z., Ferroli, R. Baldini, Ban, Y., Bennett, D. W., Bennett, J. V., Bertani, M., Bettoni, D., Bian, J. M., Bianchi, F., Boger, E., Bondarenko, O., Boyko, I., Briere, R. A., Cai, H., Cai, X., Cakir, O., Calcaterra, A., Cao, G. F., Cetin, S. A., Chang, J. F., Chelkov, G., Chen, G., Chen, H. S., Chen, H. Y., Chen, J. C., Chen, M. L., Chen, S. J., Chen, X., Chen, X. R., Chen, Y. B., Cheng, H. P., Chu, X. K., Cibinetto, G., Cronin-Hennessy, D., Dai, H. L., Dai, J. P., Dbeyssi, A., Dedovich, D., Deng, Z. Y., Denig, A., Denysenko, I., Destefanis, M., De Mori, F., Ding, Y., Dong, C., Dong, J., Dong, L. Y., Dong, M. Y., Du, S. X., Duan, P. F., Fan, J. Z., Fang, J., Fang, S. S., Fang, X., Fang, Y., Fava, L., Feldbauer, F., Felici, G., Feng, C. Q., Fioravanti, E., Fritsch, M., Fu, C. D., Gao, Q., Gao, Y., Garzia, I., Goetzen, K., Gong, W. X., Gradl, W., Greco, M., Gu, M. H., Gu, Y. T., Guan, Y. H., Guo, A. Q., Guo, L. B., Guo, T., Guo, Y., Guo, Y. P., Haddadi, Z., Hafner, A., Han, S., Han, Y. L., Harris, F. A., He, K. L., He, Z. Y., Held, T., Heng, Y. K., Hou, Z. L., Hu, C., Hu, H. M., Hu, J. F., Hu, T., Huang, Y. Hu G. M. Huang G. S., Huang, H. P., Huang, J. S., Huang, X. T., Huang, Y., Hussain, T., Ji, Q., Ji, Q. P., Ji, X. B., Ji, X. L., Jiang, L. L., Jiang, L. W., Jiang, X. S., Jiao, J. B., Jiao, Z., Jin, D. P., Jin, S., Johansson, T., Julin, A., Kalantar-Nayestanaki, N., Kang, X. L., Kang, X. S., Kavatsyuk, M., Ke, B. C., Kliemt, R., Kloss, B., Kolcud, O. B., Kopf, B., Kornicer, M., Kuehn, W., Kupsc, A., Lai, W., Lange, J. S., Lara, M., Larin, P., Li, C. H., Li, Cheng, Li, D. M., Li, F., Li, G., Li, H. B., Li, J. C., Li, Jin, Li, K., Li, P. R., Li, T., Li, W. D., Li, W. G., Li, X. L., Li, X. M., Li, X. N., Li, X. Q., Li, Z. B., Liang, H., Liang, Y. F., Liang, Y. T., Liao, G. R., Lin, D. X., Liu, B. J., Liu, C. L., Liu, C. X., Liu, F. H., Liu, Fang, Liu, Feng, Liu, H. B., Liu, H. H., Liu, H. M., Liu, J., Liu, J. P., Liu, J. Y., Liu, K., Liu, K. Y., Liu, L. D., Liu, P. L., Liu, Q., Liu, S. B., Liu, X., Liu, X. X., Liu, Y. B., Liu, Z. A., Liu, Zhiqiang, Liu, Zhiqing, Loehner, H., Loue, X. C., Lu, H. J., Lu, J. G., Lu, R. Q., Lu, Y., Lu, Y. P., Luo, C. L., Luo, M. X., Luo, T., Luo, X. L., Lv, M., Lyu, X. R., Ma, F. C., Ma, H. L., Ma, L. L., Ma, Q. M., Ma, S., Ma, T., Ma, X. N., Ma, X. Y., Maas, F. E., Maggiora, M., Malik, Q. A., Mao, Y. J., Mao, Z. P., Marcello, S., Messchendorp, J. G., Min, J., Min, T. J., Mitchell, R. E., Mo, X. H., Mo, Y. J., Morales, C. Morales, Moriya, K., Muchnoia, N. Yu., Muramatsu, H., Nefedov, Y., Nerling, F., Nikolaeva, I. B., Ning, Z., Nisar, S., Niu, S. L., Niu, X. Y., Olsen, S. L., Ouyang, Q., Pacetti, S., Patteri, P., Pelizaeus, M., Peng, H. P., Peters, K., Ping, J. L., Ping, R. G., Poling, R., Pu, Y. N., Qi, M., Qian, S., Qiao, C. F., Qin, L. Q., Qin, N., Qin, X. S., Qin, Y., Qin, Z. H., Qiu, J. F., Rashid, K. H., Redmer, C. F., Ren, H. L., Ripka, M., Rong, G., Ruan, X. D., Santoro, V., Sarantsev, A., Savrié, M., Schoenning, K., Schumann, S., Shan, W., Shao, M., Shen, C. P., Shen, P. X., Shen, X. Y., Sheng, H. Y., Shepherd, M. R., Song, W. M., Song, X. Y., Sosio, S., Spataro, S., Spruck, B., Sun, G. X., Sun, J. F., Sun, S. S., Sun, Y. J., Sun, Y. Z., Sun, Z. J., Sun, Z. T., Tang, C. J., Tang, X., Tapan, I., Thorndike, E. H., Tiemens, M., Toth, D., Ullrich, M., Uman, I., Varner, G. S., Wang, B., Wang, B. L., Wang, D., Wang, D. Y., Wang, K., Wang, L. L., Wang, L. S., Wang, M., Wang, P., Wang, P. L., Wang, Q. J., Wang, S. G., Wang, W., Wang, X. F., Wang, Y. D., Wang, Y. F., Wang, Y. Q., Wang, Z., Wang, Z. G., Wang, Z. H., Wang, Z. Y., Weber, T., Wei, D. H., Wei, J. B., Weidenkaff, P., Wen, S. P., Wiedner, U., Wolke, M., Wu, L. H., Wu, Z., Xia, L. G., Xia, Y., Xiao, D., Xiao, Z. J., Xie, Y. G., Xu, G. F., Xu, L., Xu, Q. J., Xu, Q. N., Xu, X. P., Yan, L., Yan, W. B., Yan, W. C., Yan, Y. H., Yang, H. X., Yang, L., Yang, Y., Yang, Y. X., Ye, H., Ye, M., Yin, M. H. Ye J. H., Yu, B. X., Yu, C. X., Yu, H. W., Yu, J. S., Yuan, C. Z., Yuan, W. L., Yuan, Y., Yuncug, A., Zafar, A. A., Zallo, A., Zeng, Y., Zhang, B. X., Zhang, B. Y., Zhang, C., Zhang, C. C., Zhang, D. H., Zhang, H. H., Zhang, H. Y., Zhang, J. J., Zhang, J. L., Zhang, J. Q., Zhang, J. W., Zhang, J. Y., Zhang, J. Z., Zhang, K., Zhang, L., Zhang, S. H., Zhang, X. J., Zhang, X. Y., Zhang, Y., Zhang, Y. H., Zhang, Z. H., Zhang, Z. P., Zhang, Z. Y., Zhao, G., Zhao, J. W., Zhao, J. Y., Zhao, J. Z., Zhao, Lei, Zhao, Ling, Zhao, M. G., Zhao, Q., Zhao, Q. W., Zhao, S. J., Zhao, T. C., Zhao, Y. B., Zhao, Z. G., Zhemchugovh, A., Zheng, B., Zheng, J. P., Zheng, W. J., Zheng, Y. H., Zhong, B., Zhou, L., Zhou, Li, Zhou, X., Zhou, X. K., Zhou, X. R., Zhou, X. Y., Zhu, K., Zhu, K. J., Zhu, S., Zhu, X. L., Zhu, Y. C., Zhu, Y. S., Zhu, Z. A., Zhuang, J., Zou, B. S., and Zou, J. H.
Subjects: High Energy Physics - Experiment
Abstract: Based on a sample of \etapr mesons produced in the radiative decay $J/\psi\to\gamma\eta^{\prime}$ in $1.31\times 10^9$ $J/\psi$ events collected with the BESIII detector, the decay $\eta^{\prime}\to\omega e^{+} e^{-}$ is observed for the first time, with a statistical significance of $8\sigma$. The branching fraction is measured to be $\mathcal{B}(\eta^{\prime}\to\omega e^{+} e^{-})=(1.97\pm0.34(\text{stat})\pm0.17(\text{syst}))\times10^{-4}$, which is in agreement with theoretical predictions. The branching fraction of $\eta^{\prime}\to\omega\gamma$ is also measured to be $(2.55\pm0.03(\text{stat})\pm0.16(\text{syst}))\times10^{-2}$, which is the most precise measurement to date, and the relative branching fraction $\frac{\mathcal{B}(\eta^{\prime}\to \omega e^{+}e^{-})}{\mathcal{B}(\eta^{\prime}\to \omega \gamma)}$ is determined to be $(7.71\pm1.34(\text{stat})\pm0.54(\text{syst}))\times10^{-3}$., Comment: 8 pages, 10 figures
Published: 2015
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28. Identifying the Potential Therapeutic Targets for Atopic Dermatitis Through the Immune Infiltration Analysis and Construction of a ceRNA Network

Author: Peng S, Chen M, Yin M, and Feng H
Subjects: atopic dermatitis, immunomodulation, cerna network, bioinformatics, Dermatology, RL1-803
Abstract: Shixiong Peng, Mengjiao Chen, Ming Yin, Hao Feng Department of Dermatology, The First Affiliated Hospital of Hunan Normal University/Hunan Provincial People’s Hospital, Changsha, People’s Republic of ChinaCorrespondence: Hao FengDepartment of Dermatology, The First Affiliated Hospital of Hunan Normal University/Hunan Provincial People’s Hospital, No. 61, Jiefang West Road, Changsha, 410000, Hunan Province, People’s Republic of ChinaTel/Fax +86 731 83929236Email doctorfenghao@126.comPurpose: This study was meant to analyze immune infiltration and construct a ceRNA network to explore the new therapeutic targets for atopic dermatitis (AD) through bioinformatics way.Patients and Methods: We downloaded the AD patients’ RNA expression profile datasets (GSE63741, GSE124700) from the Gene Expression Omnibus (GEO) database, which were analyzed through the GEO2R. We explored the hub genes by the enrichment analysis and the protein–protein interaction (PPI) analysis. Moreover, we estimated immune cell types and their proportions by ImmucellAI. GSE121212 dataset validation was performed to verify the robustness of the hub genes. Then, a ceRNA network was constructed by the miRWalk, miRNet, miRDB, DIANA, TargetScan, and starbase database. Finally, gene expression analysis was performed by using RT-qPCR.Results: In total, we detected 22 differentially expressed genes (DEGs), which contained 8 downregulated genes and 14 upregulated genes. There were 5 hub genes confirmed as key genes through PPI network analysis and the ROC curves. KEGG pathway analysis revealed that they were significantly enriched in the IL-17 signaling pathway and GO analysis showed mainly in the immune cell chemotaxis. The immune infiltration profiles were different between normal controls and AD, and each of the key genes (S100A7, S100A8, S100A9, and LCE3D) was significantly correlated with the main infiltration cell of AD. A lncRNA–miRNA–mRNA ceRNA network containing the key genes was constructed, and NEAT1 and XIST, the core of ceRNA network, were significantly overexpressing verified by RT-qPCR in AD patients.Conclusion: Altogether, the key genes and their ceRNA network provided a novel perspective to the immunomodulation of AD, which may be potential and new therapeutic targets for AD.Keywords: atopic dermatitis, immunomodulation, ceRNA network, bioinformatics
Published: 2021

29. Study of J/psi->eta phi pi+pi- at BESIII

Author: Ablikim, M., Achasov, M. N., Ai, X. C., Albayrak, O., Albrecht, M., Ambrose, D. J., Amoroso, A., An, F. F., An, Q., Bai, J. Z., Ferroli, R. Baldini, Ban, Y., Bennett, D. W., Bennett, J. V., Bertani, M., Bettoni, D., Bian, J. M., Bianchi, F., Boger, E., Bondarenko, O., Boyko, I., Briere, R. A., Cai, H., Cai, X., Cakir, O., Calcaterra, A., Cao, G. F., Cetin, S. A., Chang, J. F., Chelkov, G., Chen, G., Chen, H. S., Chen, H. Y., Chen, J. C., Chen, M. L., Chen, S. J., Chen, X., Chen, X. R., Chen, Y. B., Cheng, H. P., Chu, X. K., Cibinetto, G., Cronin-Hennessy, D., Dai, H. L., Dai, J. P., Dbeyssi, A., Dedovich, D., Deng, Z. Y., Denig, A., Denysenko, I., Destefanis, M., De Mori, F., Ding, Y., Dong, C., Dong, J., Dong, L. Y., Dong, M. Y., Du, S. X., Duan, P. F., Fan, J. Z., Fang, J., Fang, S. S., Fang, X., Fang, Y., Fava, L., Feldbauer, F., Felici, G., Feng, C. Q., Fioravanti, E., Fritsch, M., Fu, C. D., Gao, Q., Gao, Y., Garzia, I., Goetzen, K., Gong, W. X., Gradl, W., Greco, M., Gu, M. H., Gu, Y. T., Guan, Y. H., Guo, A. Q., Guo, L. B., Guo, T., Guo, Y., Guo, Y. P., Haddadi, Z., Hafner, A., Han, S., Han, Y. L., Harris, F. A., He, K. L., He, Z. Y., Held, T., Heng, Y. K., Hou, Z. L., Hu, C., Hu, H. M., Hu, J. F., Hu, T., Huang, Y. Hu G. M. Huang G. S., Huang, H. P., Huang, J. S., Huang, X. T., Huang, Y., Hussain, T., Ji, Q., Ji, Q. P., Ji, X. B., Ji, X. L., Jiang, L. L., Jiang, L. W., Jiang, X. S., Jiao, J. B., Jiao, Z., Jin, D. P., Jin, S., Johansson, T., Julin, A., Kalantar-Nayestanaki, N., Kang, X. L., Kang, X. S., Kavatsyuk, M., Ke, B. C., Kliemt, R., Kloss, B., Kolcud, O. B., Kopf, B., Kornicer, M., Kuehn, W., Kupsc, A., Lai, W., Lange, J. S., Lara, M., Larin, P., Li, C. H., Li, Cheng, Li, D. M., Li, F., Li, G., Li, H. B., Li, J. C., Li, Jin, Li, K., Li, P. R., Li, T., Li, W. D., Li, W. G., Li, X. L., Li, X. M., Li, X. N., Li, X. Q., Li, Z. B., Liang, H., Liang, Y. F., Liang, Y. T., Liao, G. R., Lin, D. X., Liu, B. J., Liu, C. L., Liu, C. X., Liu, F. H., Liu, Fang, Liu, Feng, Liu, H. B., Liu, H. H., Liu, H. M., Liu, J., Liu, J. P., Liu, J. Y., Liu, K., Liu, K. Y., Liu, L. D., Liu, P. L., Liu, Q., Liu, S. B., Liu, X., Liu, X. X., Liu, Y. B., Liu, Z. A., Liu, Zhiqiang, Liu, Zhiqing, Loehner, H., Loue, X. C., Lu, H. J., Lu, J. G., Lu, R. Q., Lu, Y., Lu, Y. P., Luo, C. L., Luo, M. X., Luo, T., Luo, X. L., Lv, M., Lyu, X. R., Ma, F. C., Ma, H. L., Ma, L. L., Ma, Q. M., Ma, S., Ma, T., Ma, X. N., Ma, X. Y., Maas, F. E., Maggiora, M., Malik, Q. A., Mao, Y. J., Mao, Z. P., Marcello, S., Messchendorp, J. G., Min, J., Min, T. J., Mitchell, R. E., Mo, X. H., Mo, Y. J., Morales, C. Morales, Moriya, K., Muchnoia, N. Yu., Muramatsu, H., Nefedov, Y., Nerling, F., Nikolaeva, I. B., Ning, Z., Nisar, S., Niu, S. L., Niu, X. Y., Olsen, S. L., Ouyang, Q., Pacetti, S., Patteri, P., Pelizaeus, M., Peng, H. P., Peters, K., Ping, J. L., Ping, R. G., Poling, R., Pu, Y. N., Qi, M., Qian, S., Qiao, C. F., Qin, L. Q., Qin, N., Qin, X. S., Qin, Y., Qin, Z. H., Qiu, J. F., Rashid, K. H., Redmer, C. F., Ren, H. L., Ripka, M., Rong, G., Ruan, X. D., Santoro, V., Sarantsev, A., Savrié, M., Schoenning, K., Schumann, S., Shan, W., Shao, M., Shen, C. P., Shen, P. X., Shen, X. Y., Sheng, H. Y., Shepherd, M. R., Song, W. M., Song, X. Y., Sosio, S., Spataro, S., Spruck, B., Sun, G. X., Sun, J. F., Sun, S. S., Sun, Y. J., Sun, Y. Z., Sun, Z. J., Sun, Z. T., Tang, C. J., Tang, X., Tapan, I., Thorndike, E. H., Tiemens, M., Toth, D., Ullrich, M., Uman, I., Varner, G. S., Wang, B., Wang, B. L., Wang, D., Wang, D. Y., Wang, K., Wang, L. L., Wang, L. S., Wang, M., Wang, P., Wang, P. L., Wang, Q. J., Wang, S. G., Wang, W., Wang, X. F., Wang, Y. D., Wang, Y. F., Wang, Y. Q., Wang, Z., Wang, Z. G., Wang, Z. H., Wang, Z. Y., Weber, T., Wei, D. H., Wei, J. B., Weidenkaff, P., Wen, S. P., Wiedner, U., Wolke, M., Wu, L. H., Wu, Z., Xia, L. G., Xia, Y., Xiao, D., Xiao, Z. J., Xie, Y. G., Xu, G. F., Xu, L., Xu, Q. J., Xu, Q. N., Xu, X. P., Yan, L., Yan, W. B., Yan, W. C., Yan, Y. H., Yang, H. X., Yang, L., Yang, Y., Yang, Y. X., Ye, H., Ye, M., Yin, M. H. Ye J. H., Yu, B. X., Yu, C. X., Yu, H. W., Yu, J. S., Yuan, C. Z., Yuan, W. L., Yuan, Y., Yuncug, A., Zafar, A. A., Zallo, A., Zeng, Y., Zhang, B. X., Zhang, B. Y., Zhang, C., Zhang, C. C., Zhang, D. H., Zhang, H. H., Zhang, H. Y., Zhang, J. J., Zhang, J. L., Zhang, J. Q., Zhang, J. W., Zhang, J. Y., Zhang, J. Z., Zhang, K., Zhang, L., Zhang, S. H., Zhang, X. J., Zhang, X. Y., Zhang, Y., Zhang, Y. H., Zhang, Z. H., Zhang, Z. P., Zhang, Z. Y., Zhao, G., Zhao, J. W., Zhao, J. Y., Zhao, J. Z., Zhao, Lei, Zhao, Ling, Zhao, M. G., Zhao, Q., Zhao, Q. W., Zhao, S. J., Zhao, T. C., Zhao, Y. B., Zhao, Z. G., Zhemchugovh, A., Zheng, B., Zheng, J. P., Zheng, W. J., Zheng, Y. H., Zhong, B., Zhou, L., Zhou, Li, Zhou, X., Zhou, X. K., Zhou, X. R., Zhou, X. Y., Zhu, K., Zhu, K. J., Zhu, S., Zhu, X. L., Zhu, Y. C., Zhu, Y. S., Zhu, Z. A., Zhuang, J., Zou, B. S., and Zou, J. H.
Subjects: High Energy Physics - Experiment
Abstract: Based on a sample of $2.25\times 10^{8} J/\psi$ events taken with the BESIII detector at the BEPCII collider, we present the results of a study of the decay $J/\psi\to \eta \phi\pi^{+}\pi^{-}$. The $Y(2175)$ resonance is observed in the invariant mass spectrum of $\phi f_{0}(980)$ with a statistical significance of greater than $10\sigma$. The corresponding mass and width are determined to be $M=2200\pm 6 \mathrm{(stat.)} \pm 5\mathrm{(syst.)} \mathrm{MeV}/c^{2}$ and $\Gamma=104\pm 15\mathrm{(stat.)}\pm 15\mathrm{(syst.)}$ MeV, respectively, and the product branching fraction is measured to be $\mathcal{B}(J/\psi\to\eta Y(2175)$, $Y(2175)\to \phi f_{0}(980)$, $f_{0}(980)\to \pi^{+}\pi^{-})= (1.20\pm 0.14\mathrm{(stat.)}\pm 0.37 \mathrm{(syst.)})\times 10^{-4}$. The results are consistent within errors with those of previous experiments. We also measure the branching fraction of $J/\psi\to \phi f_1(1285)$ with $f_1(1285)\to \eta\pi^{+}\pi^{-}$ and set upper limits on the branching fractions for $J/\psi\to \phi\eta(1405)$/$\phi X(1835)$/$\phi X(1870)$ with $\eta(1405)$/$X(1835)$/$X(1870)\to \eta\pi^{+}\pi^{-}$ at the 90\% confidence level., Comment: 11 pages, 11 figures
Published: 2014
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30. Search for the $Y(4140)$ via $e^{+} e^{-} \to \gamma \phi J/\psi$ at $\sqrt{s}=$ 4.23, 4.26 and 4.36 GeV

Author: Ablikim, M., Achasov, M. N., Ai, X. C., Albayrak, O., Albrecht, M., Ambrose, D. J., Amoroso, A., An, F. F., An, Q., Bai, J. Z., Ferroli, R. Baldini, Ban, Y., Bennett, D. W., Bennett, J. V., Bertani, M., Bettoni, D., Bian, J. M., Bianchi, F., Boger, E., Bondarenko, O., Boyko, I., Briere, R. A., Cai, H., Cai, X., Cakir, O., Calcaterra, A., Cao, G. F., Cetin, S. A., Chang, J. F., Chelkov, G., Chen, G., Chen, H. S., Chen, H. Y., Chen, J. C., Chen, M. L., Chen, S. J., Chen, X., Chen, X. R., Chen, Y. B., Cheng, H. P., Chu, X. K., Cibinetto, G., Cronin-Hennessy, D., Dai, H. L., Dai, J. P., Dbeyssi, A., Dedovich, D., Deng, Z. Y., Denig, A., Denysenko, I., Destefanis, M., De Mori, F., Ding, Y., Dong, C., Dong, J., Dong, L. Y., Dong, M. Y., Du, S. X., Duan, P. F., Fan, J. Z., Fang, J., Fang, S. S., Fang, X., Fang, Y., Fava, L., Feldbauer, F., Felici, G., Feng, C. Q., Fioravanti, E., Fritsch, M., Fu, C. D., Gao, Q., Gao, Y., Garzia, I., Goetzen, K., Gong, W. X., Gradl, W., Greco, M., Gu, M. H., Gu, Y. T., Guan, Y. H., Guo, A. Q., Guo, L. B., Guo, T., Guo, Y., Guo, Y. P., Haddadi, Z., Hafner, A., Han, S., Han, Y. L., Harris, F. A., He, K. L., He, Z. Y., Held, T., Heng, Y. K., Hou, Z. L., Hu, C., Hu, H. M., Hu, J. F., Hu, T., Huang, Y. Hu G. M. Huang G. S., Huang, H. P., Huang, J. S., Huang, X. T., Huang, Y., Hussain, T., Ji, Q., Ji, Q. P., Ji, X. B., Ji, X. L., Jiang, L. L., Jiang, L. W., Jiang, X. S., Jiao, J. B., Jiao, Z., Jin, D. P., Jin, S., Johansson, T., Julin, A., Kalantar-Nayestanaki, N., Kang, X. L., Kang, X. S., Kavatsyuk, M., Ke, B. C., Kliemt, R., Kloss, B., Kolcud, O. B., Kopf, B., Kornicer, M., Kuehn, W., Kupsc, A., Lai, W., Lange, J. S., Lara, M., Larin, P., Li, C. H., Li, Cheng, Li, D. M., Li, F., Li, G., Li, H. B., Li, J. C., Li, Jin, Li, K., Li, P. R., Li, T., Li, W. D., Li, W. G., Li, X. L., Li, X. M., Li, X. N., Li, X. Q., Li, Z. B., Liang, H., Liang, Y. F., Liang, Y. T., Liao, G. R., Lin, D. X., Liu, B. J., Liu, C. L., Liu, C. X., Liu, F. H., Liu, Fang, Liu, Feng, Liu, H. B., Liu, H. H., Liu, H. M., Liu, J., Liu, J. P., Liu, J. Y., Liu, K., Liu, K. Y., Liu, L. D., Liu, P. L., Liu, Q., Liu, S. B., Liu, X., Liu, X. X., Liu, Y. B., Liu, Z. A., Liu, Zhiqiang, Liu, Zhiqing, Loehner, H., Loue, X. C., Lu, H. J., Lu, J. G., Lu, R. Q., Lu, Y., Lu, Y. P., Luo, C. L., Luo, M. X., Luo, T., Luo, X. L., Lv, M., Lyu, X. R., Ma, F. C., Ma, H. L., Ma, L. L., Ma, Q. M., Ma, S., Ma, T., Ma, X. N., Ma, X. Y., Maas, F. E., Maggiora, M., Malik, Q. A., Mao, Y. J., Mao, Z. P., Marcello, S., Messchendorp, J. G., Min, J., Min, T. J., Mitchell, R. E., Mo, X. H., Mo, Y. J., Morales, C. Morales, Moriya, K., Muchnoia, N. Yu., Muramatsu, H., Nefedov, Y., Nerling, F., Nikolaeva, I. B., Ning, Z., Nisar, S., Niu, S. L., Niu, X. Y., Olsen, S. L., Ouyang, Q., Pacetti, S., Patteri, P., Pelizaeus, M., Peng, H. P., Peters, K., Ping, J. L., Ping, R. G., Poling, R., Pu, Y. N., Qi, M., Qian, S., Qiao, C. F., Qin, L. Q., Qin, N., Qin, X. S., Qin, Y., Qin, Z. H., Qiu, J. F., Rashid, K. H., Redmer, C. F., Ren, H. L., Ripka, M., Rong, G., Ruan, X. D., Santoro, V., Sarantsev, A., Savrié, M., Schoenning, K., Schumann, S., Shan, W., Shao, M., Shen, C. P., Shen, P. X., Shen, X. Y., Sheng, H. Y., Shepherd, M. R., Song, W. M., Song, X. Y., Sosio, S., Spataro, S., Spruck, B., Sun, G. X., Sun, J. F., Sun, S. S., Sun, Y. J., Sun, Y. Z., Sun, Z. J., Sun, Z. T., Tang, C. J., Tang, X., Tapan, I., Thorndike, E. H., Tiemens, M., Toth, D., Ullrich, M., Uman, I., Varner, G. S., Wang, B., Wang, B. L., Wang, D., Wang, D. Y., Wang, K., Wang, L. L., Wang, L. S., Wang, M., Wang, P., Wang, P. L., Wang, Q. J., Wang, S. G., Wang, W., Wang, X. F., Wang, Y. D., Wang, Y. F., Wang, Y. Q., Wang, Z., Wang, Z. G., Wang, Z. H., Wang, Z. Y., Weber, T., Wei, D. H., Wei, J. B., Weidenkaff, P., Wen, S. P., Wiedner, U., Wolke, M., Wu, L. H., Wu, Z., Xia, L. G., Xia, Y., Xiao, D., Xiao, Z. J., Xie, Y. G., Xu, G. F., Xu, L., Xu, Q. J., Xu, Q. N., Xu, X. P., Yan, L., Yan, W. B., Yan, W. C., Yan, Y. H., Yang, H. X., Yang, L., Yang, Y., Yang, Y. X., Ye, H., Ye, M., Yin, M. H. Ye J. H., Yu, B. X., Yu, C. X., Yu, H. W., Yu, J. S., Yuan, C. Z., Yuan, W. L., Yuan, Y., Yuncug, A., Zafar, A. A., Zallo, A., Zeng, Y., Zhang, B. X., Zhang, B. Y., Zhang, C., Zhang, C. C., Zhang, D. H., Zhang, H. H., Zhang, H. Y., Zhang, J. J., Zhang, J. L., Zhang, J. Q., Zhang, J. W., Zhang, J. Y., Zhang, J. Z., Zhang, K., Zhang, L., Zhang, S. H., Zhang, X. J., Zhang, X. Y., Zhang, Y., Zhang, Y. H., Zhang, Z. H., Zhang, Z. P., Zhang, Z. Y., Zhao, G., Zhao, J. W., Zhao, J. Y., Zhao, J. Z., Zhao, Lei, Zhao, Ling, Zhao, M. G., Zhao, Q., Zhao, Q. W., Zhao, S. J., Zhao, T. C., Zhao, Y. B., Zhao, Z. G., Zhemchugovh, A., Zheng, B., Zheng, J. P., Zheng, W. J., Zheng, Y. H., Zhong, B., Zhou, L., Zhou, Li, Zhou, X., Zhou, X. K., Zhou, X. R., Zhou, X. Y., Zhu, K., Zhu, K. J., Zhu, S., Zhu, X. L., Zhu, Y. C., Zhu, Y. S., Zhu, Z. A., Zhuang, J., Zou, B. S., and Zou, J. H.
Subjects: High Energy Physics - Experiment
Abstract: Using data samples collected at center-of-mass energies $\sqrt{s} = 4.23$, 4.26, and 4.36 GeV with the BESIII detector operating at the BEPCII storage ring, we search for the production of the charmoniumlike state $Y(4140)$ through a radiative transition followed by its decay to $\phi J/\psi$. No significant signal is observed and upper limits on $\sigma[e^{+} e^{-} \rightarrow \gamma Y(4140)] \cdot \mathcal{B}(Y(4140)\rightarrow \phi J/\psi)$ at the $90\%$ confidence level are estimated as 0.35, 0.28, and 0.33 pb at $\sqrt{s} = 4.23$, 4.26, and 4.36 GeV, respectively.
Published: 2014
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31. Target-Driven Tissue-Agnostic Drug Approvals—A New Path of Drug Development.

Author: Thein, Kyaw Z., Myat, Yin M., Park, Byung S., Panigrahi, Kalpana, and Kummar, Shivaani
Subjects: *THERAPEUTIC use of antineoplastic agents, *MITOGEN-activated protein kinases, *GENOMICS, *ANTINEOPLASTIC agents, *PROGRAMMED death-ligand 1, *PROTEIN-tyrosine kinase inhibitors, *TUMOR markers, *DRUG approval, *IMMUNE checkpoint inhibitors, *ONCOGENES, *TUMORS, *DRUG development, *GENETIC mutation, *INDIVIDUALIZED medicine
Abstract: Simple Summary: Precision oncology is at the forefront of personalized cancer care, utilizing tumor-agnostic therapies that target specific biomarkers, such as tumor mutational burden, microsatellite instability, mutations, or fusions, regardless of cancer type. This review aims to provide a comprehensive summary of the immune checkpoint inhibitors and the targeted therapies approved by the US Food and Drug Administration (FDA) for tumor-agnostic use. We thoroughly reviewed pembrolizumab, dostarlimab, larotrectinib, entrectinib, selpercatinib, dabrafenib plus trametinib, and trastuzumab deruxtecan across eight indications, detailing their efficacy, toxicity, and regulatory history. Additionally, we highlight the critical role of biostatistics in designing the clinical trials necessary for evaluating these treatments. These insights advance our understanding of biomarker-driven approaches, guide future research directions, and support the development of more effective, personalized cancer treatments across diverse histology. The regulatory approvals of tumor-agnostic therapies have led to the re-evaluation of the drug development process. The conventional models of drug development are histology-based. On the other hand, the tumor-agnostic drug development of a new drug (or combination) focuses on targeting a common genomic biomarker in multiple cancers, regardless of histology. The basket-like clinical trials with multiple cohorts allow clinicians to evaluate pan-cancer efficacy and toxicity. There are currently eight tumor agnostic approvals granted by the Food and Drug Administration (FDA). This includes two immune checkpoint inhibitors, and five targeted therapy agents. Pembrolizumab is an anti-programmed cell death protein-1 (PD-1) antibody that was the first FDA-approved tumor-agnostic treatment for unresectable or metastatic microsatellite instability-high (MSI-H) or deficient mismatch repair (dMMR) solid tumors in 2017. It was later approved for tumor mutational burden-high (TMB-H) solid tumors, although the TMB cut-off used is still debated. Subsequently, in 2021, another anti-PD-1 antibody, dostarlimab, was also approved for dMMR solid tumors in the refractory setting. Patients with fusion-positive cancers are typically difficult to treat due to their rare prevalence and distribution. Gene rearrangements or fusions are present in a variety of tumors. Neurotrophic tyrosine kinase (NTRK) fusions are present in a range of pediatric and adult solid tumors in varying frequency. Larotrectinib and entrectinib were approved for neurotrophic tyrosine kinase (NTRK) fusion-positive cancers. Similarly, selpercatinib was approved for rearranged during transfection (RET) fusion-positive solid tumors. The FDA approved the first combination therapy of dabrafenib, a B-Raf proto-oncogene serine/threonine kinase (BRAF) inhibitor, plus trametinib, a mitogen-activated protein kinase (MEK) inhibitor for patients 6 months or older with unresectable or metastatic tumors (except colorectal cancer) carrying a BRAFV600E mutation. The most recent FDA tumor-agnostic approval is of fam-trastuzumab deruxtecan-nxki (T-Dxd) for HER2-positive solid tumors. It is important to identify and expeditiously develop drugs that have the potential to provide clinical benefit across tumor types. [ABSTRACT FROM AUTHOR]
Published: 2024
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32. Genetic Variants of the MIF Gene and Susceptibility of Rectal Cancer

Author: Chuo D, Lin D, Yin M, and Chen Y
Subjects: rectal cancer, genetic, mif, susceptibility, case-control, Therapeutics. Pharmacology, RM1-950
Abstract: Dongyu Chuo, Dapeng Lin, Mingdi Yin, Yuze Chen Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning Province 110042, People’s Republic of ChinaCorrespondence: Yuze ChenColorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, No. 44 Xiaoheyan Road, Dadong District, Shenyang, Liaoning Province 110042, People’s Republic of ChinaTel/Fax +86-24-31916243Email chen_yuze@aliyun.comBackground: Rectal cancer (RC) has been documented to be a highly invasive malignant neoplasm worldwide. Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine involved in cell-mediated immunity, immunoregulation, inflammation. In vitro and in vivo studies have identified that MIF was involved in the carcinogenesis and progression of RC.Patients and Methods: This case–control study evaluated associations of genetic variants of the MIF gene and serum level of MIF with susceptibility of RC.Results: We found MIF level was associated with an increased risk of RC (OR for per unit: 1.38, 95% CI:1.32– 1.44; P
Published: 2021

33. In situ Fabrication of Nano ZnO/BCM Biocomposite Based on MA Modified Bacterial Cellulose Membrane for Antibacterial and Wound Healing

Author: Luo Z, Liu J, Lin H, Ren X, Tian H, Liang Y, Wang W, Wang Y, Yin M, Huang Y, and Zhang J
Subjects: bacterial cellulose, nano-zinc oxide, in situ synthesis, antibacterial, non-toxicity, wound dressing, Medicine (General), R5-920
Abstract: Zhenghui Luo,1,* Jie Liu,1,* Hai Lin,2 Xi Ren,1 Hao Tian,1 Yi Liang,1 Weiyi Wang,1 Yuan Wang,1 Meifang Yin,1 Yuesheng Huang,1 Jiaping Zhang1 1Department of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing 400038, People’s Republic of China; 2Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610065, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiaping ZhangDepartment of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing 400038, People’s Republic of ChinaTel +86 23-68754353Email japzhang@aliyun.comBackground: Developing an ideal wound dressing that meets the multiple demands of safe and practical, good biocompatibility, superior mechanical property and excellent antibacterial activity is highly desirable for wound healing. Bacterial cellulose (BC) is one of such promising class of biopolymers since it can control wound exudates and can provide moist environment to a wound resulting in better wound healing. However, the lack of antibacterial activity has limited its application.Methods and Results: We prepared a flexible dressing based on a bacterial cellulose membrane and then modified it by chemical crosslinking to prepare in situ synthesis of nZnO/BCM via a facile and eco-friendly approach. Scanning electron microscopy (SEM) results indicated that nZnO/BCM membranes were characterized by an ideal porous structure (pore size: 30∼ 90 μm), forming a unique string-beaded morphology. The average water vapor transmission of nZnO/BCM was 2856.60 g/m2/day, which improved the moist environment of nZnO/BCM. ATR-FITR further confirmed the stepwise deposition of nano-zinc oxide. Tensile testing indicated that our nanocomposites were flexible, comfortable and resilient. Bacterial suspension assay and plate counting methods demonstrated that 5wt. % nZnO/BCM possessed excellent antibacterial activity against S.aureus and E. coli, while MTT assay demonstrated that they had no measurable cytotoxicity toward mammalian cells. Moreover, skin irritation test and histocompatibility examination supported that 5wt. % nZnO/BCM had no stimulation to skin and had acceptable biocompatibility with little infiltration of the inflammatory cells. Finally, by using a bacteria-infected (S. aureus and E. coli) murine wound model, we found that nZnO/BCM could prevent in vivo bacterial infections and promote wound healing via accelerating the re-epithelialization and wound contraction, and these membranes had no obvious toxicity toward normal tissues.Conclusion: Therefore, the constructed nZnO/BCM has great potential for biomedical applications as an efficient antibacterial wound dressing.Keywords: bacterial cellulose, nano-zinc oxide, in situ synthesis, antibacterial, non-toxicity, wound dressing
Published: 2020

34. Extraction of crystal-field parameters for lanthanide ions from quantum-chemical calculations

Author: Hu, L., Reid, M. F., Duan, C. K., Xia, S., and Yin, M.
Subjects: Condensed Matter - Materials Science, Physics - Chemical Physics
Abstract: A simple method for constructing effective Hamiltonians for the 4fN and 4fN-15d energy levels of lanthanide ions in crystals from quantum-chemical calculations is presented. The method is demonstrated by deriving crystal-field and spin-orbit parameters for Ce3+ ions doped in LiYF4, Cs2NaYCl6, CaF2, KY3F10 and YAG host crystals from quantum chemical calculations based on the DV-X{\alpha} method. Good agreement between calculated and fitted values of the crystal-field parameters is obtained. The method can be used to calculate parameters even for low-symmetry sites where there are more parameters than energy levels.
Published: 2010
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35. The first intron of EIJ1 confers a specific response to wounding and herbivore stresses.

Author: Yin, M., Li, Y., and Liu, H.
Subjects: *DISEASE resistance of plants, *HERBIVORES, *ARABIDOPSIS thaliana, *WOUNDS & injuries
Abstract: Plants are constantly exposed to different kinds of biotic stress, such as herbivore attack and wounding. To deal with these stresses, plants have evolved sophisticated defence mechanisms to protect themselves.Previously, we found that EIJ1 (EDS1‐interacting J protein 1) plays a negative regulatory role in plant disease resistance in Arabidopsis thaliana. Follow‐up studies revealed that EIJ1 specifically responds to wounding and herbivore stresses. The expression of EIJ1 was specifically induced by wounding or herbivore stress, as demonstrated by similar results in EIJ1 protein assay.Interestingly, GUS staining found that the promoter of EIJ1 is not involved in the induction of expression under wounding stress. Instead, we identified the first intron of EIJ1 as a key factor in response to wounding stress. Deleting the first intron of EIJ1 resulted in a loss of response to wounding stress in plants.Our results broaden the role of EIJ1 in plant resistance to biotic stress and provide new insights into plant responses to biotic stress. [ABSTRACT FROM AUTHOR]
Published: 2024
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36. AweRAN

Author: Kak, A., primary, Thieu, H. -T., additional, Pham, V. -Q., additional, Sheshadri, R. K., additional, Choi, N., additional, Guan, Y., additional, Yin, M., additional, and Han, T., additional
Published: 2023
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37. Validation of the Chinese version of the Health Cognitions Questionnaire in Chinese college students

Author: Dai L, Xu Z, Yin M, Wang X, and Deng Y
Subjects: health anxiety, dysfunctional beliefs, health cognitions, cognitive behavior model, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: Lisha Dai,1 Zan Xu,2 Meng Yin,1 Xiang Wang,1 Yunlong Deng1,31Clinical Psychology Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, People’s Republic of China; 2Student Affairs Department, Central South University, Changsha, Hunan 410000, People’s Republic of China; 3Psychosomatic Health Institute, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, People’s Republic of ChinaPurpose: The cognitive behavioral model is considered the most comprehensive for explaining the pathogenesis of health anxiety (HA). The model proposes 4 dysfunctional beliefs that play a vital role in developing and sustaining HA: a) the likelihood of contracting or having an illness, b) awfulness of the illness, c) difficulty coping with illness, and d) inadequacy of medical services. The Health Cognitions Questionnaire (HCQ), widely used in English populations, was developed for assessing these core cognitions. As HA is a growing problem in China, we translated the HCQ into a Chinese version (CHCQ) and examined its psychometric properties. These core cognitions were compared among individuals with and without medical conditions.Methods: A set of questionnaires that included the CHCQ and the Short Health Anxiety Inventory (SHAI) was used to gather data from 1,319 Chinese college students. After 4 weeks, 145 of the students completed the CHCQ again. The validity, reliability, and measurement invariance were evaluated among individuals with various medical conditions.Results: The final CHCQ included 19 items. A 4-factor structure was well suited to the data. Good internal consistency (Cronbach’s α for total score was 0.849, subscales ranged from 0.753 to 0.841), test–retest reliability (the interclass correlation coefficient for total score was 0.762, subscales ranged from 0.626 to 0.683), and criterion validity of the CHCQ were demonstrated. Measurement and structural invariance were established. Individuals with a diagnosed disease scored higher on the likelihood-of-illness subscale (Cohen’s d =0.22, p < 0.01) than those without an illness.Conclusion: The CHCQ shows promise for the assessment of 4 core HA-related cognitions in the Chinese population.Keywords: health anxiety, dysfunctional beliefs, health cognitions, cognitive behavioral model
Published: 2019

38. Evaluation of a simple off-the-shelf bi-layered vascular scaffold based on poly(L-lactide-co-ε-caprolactone)/silk fibroin in vitro and in vivo

Author: Jin D, Hu J, Xia D, Liu A, Kuang H, Du J, Mo X, and Yin M
Subjects: silk fibroin, small-caliber, vascular remodeling, hybrid strategy, Medicine (General), R5-920
Abstract: Dawei Jin,1,* Junfeng Hu,2,* Dekai Xia,1 A’li Liu,3 Haizhu Kuang,2 Jun Du,3 Xiumei Mo,2 Meng Yin11Department of Cardiothoracic Surgery, Shanghai Children‘s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People’s Republic of China; 2State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People’s Republic of China; 3Imaging Diagnosis Center, Shanghai Children‘s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People’s Republic of China*These authors contributed equally to this work Purpose: In the field of small-caliber vascular scaffold research, excellent vascular remodeling is the key to ensuring anticoagulant function. We prepared an off-the-shelf bi-layered vascular scaffold with a dense inner layer and a loose outer layer and evaluated its remodeling capabilities by in vivo transplantation.Materials and Methods: Based on poly(L-lactide-co-ϵ-caprolactone) (PLCL), silk fibroin(SF), and heparin (Hep), PLCL/SF/Hep bi-layered scaffolds and PLCL/Hep bi-layered scaffolds were prepared by electrospinning. The inner layer was a PLCL/SF/Hep or PLCL/Hep nanofiber membrane, and the outer layer was PLCL/SF nano yarn. The in vitro tests included a hydrophilicity test, mechanical properties test, and blood and cell compatibility evaluation. The in vivo evaluation was conducted via single rabbit carotid artery replacement and subsequent examinations, including ultrasound imaging, immunoglobulin assays, and tissue section staining.Results: Compared to the PLCL/Hep nanofiber membrane, the hydrophilicity of the PLCL/SF/Hep nanofiber membrane was significantly improved. The mechanical strength met application requirements. Both the blood and cell compatibility were optimal. Most importantly, the PLCL/SF/Hep scaffolds maintained lumen patency for 3 months after carotid artery transplantation in live rabbits. At the same time, CD31 and α-SMA immunofluorescence staining confirmed bionic endothelial and smooth muscle layers remodeling.Conclusion: Using this hybrid strategy, PLCL and SF were combined to manufacture bi-layered small-caliber vascular scaffolds; these PLCL/SF/Hep scaffolds showed satisfactory vascular remodelingKeywords: silk fibroin, small-caliber, vascular remodeling, hybrid strategy
Published: 2019

39. The factor structure, reliability and validity of the Chinese version of the Van Dream Anxiety Scale

Author: Wang X, Dai L, Yin M, and Deng YL
Subjects: Nightmare, Dream Anxiety, assessment, Chinese population, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: Xiang Wang,1 Lisha Dai,1 Meng Yin,1 Yunlong Deng1,2 1Department of Clinical Psychology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China; 2Psychosomatic Health Institute, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China Background/purpose: Dream emotions and contents are associated with psychological well-being. Dream disturbances, such as frequent nightmares and dream anxiety, are associated with a variety of psychopathological conditions. Therefore, it is important to consider nightmares and the resulting dream anxiety. To address this issue, the Van Dream Anxiety Scale (VDAS) was designed especially for measuring nightmare frequency and dream anxiety caused by frightening dreams. As a Chinese version of VDAS may be helpful in promoting study of nightmare and dream anxiety among Chinese population, in the current study, we sought to develop a Chinese version of the VDAS (CVDAS). Methods: We translated the VDAS into Chinese. To evaluate its validity and reliability, a sample of 1,081 Chinese college students from two universities answered the CVDAS, GAD-7, PHQ-9 and EPQ-R-N. Ninety of them answered the CVDAS twice. We also conducted exploratory factor analysis (EFA) to explore the structure of CVDAS. Results: Excellent internal consistency (Cronbach’s alpha coefficient was 0.926), split-half reliability (equal-length Spearman–Brown coefficient was 0.938) and good test–retest reliability (the intraclass correlation coefficient was 0.942 and t=-1.478, P=0.143) of the CVDAS was presented. Exploratory factor analyses indicated a two-factor structure: sleep-related disturbances caused by nightmares and dysfunction caused by nightmares. Convergent and divergent validities were acceptable. Conclusion: The CVDAS shows promise for the measurement of nightmare frequency and specific dream anxiety in Chinese population. Future study should confirm the reliability and validity in the clinical population and further improve this scale. Keywords: nightmare, dream anxiety, assessment, Chinese population
Published: 2018

40. The earliest high-fired glazed ceramics in China : scientific studies of the proto-porcelain from Zhejiang during the Shang and Zhou periods (c.1700-221 BC)

Author: Yin, M., Rehren, T., and Freestone, I.
Subjects: 930
Abstract: Proto-porcelain, a kind of high-fired lime-rich glazed ceramic, with maturing temperatures in excess of 1200 °C, began to appear in China during the Shang dynasty (c. 1700 to 1027 BC) and became more widespread during the subsequent Zhou dynasty (1027 to 221 BC). Since the 1950s, proto-porcelain has been unearthed from various tombs and sites across the country; most of them in mound tombs and kiln sites in the lower reaches of the Yangtze River. Bodies and glazes of 61 proto-porcelain sherds and 19 non proto-porcelain samples from Shang and Zhou periods production sites in Deqing, Zhejiang province were collected and later analysed by EPMA-WDS to understand the raw materials and to explore the mechanisms behind the formation of these glazes. The results indicate that the bodies of all samples were made from local raw material – porcelain stone. Wood ashes, high in lime and low in potash, were intentionally applied to the proto-porcelain samples, resulting in the formation of lime-rich glazes whose composition were determined by a temperature-controlled mechanism. In contrast, kiln fragments and furniture show a potash-rich fuel vapour glaze, which formed unintentionally during use of the kiln. The firing temperature for most of the proto-porcelain glazes is about the same as the maturing temperature for typical more recent lime glazes, showing that the potters were already at such an early time able to attain sufficiently high temperature in their kilns. The differences in firing temperature and composition underpin the suggestion that the Chinese lime-rich glazes are an independent invention. The glaze-forming process was later replicated in the lab to further test several possible parameters that would be necessary to control for the early potters when producing these glazes on a regular scale. The emergence of these earliest high-fired glazed ceramics has also been contextualised within north and south China during the Shang and Zhou dynasties. The environmental and technological constraints, economic and political organisations, together with religious and belief systems were also taken into consideration to better understand the impact of this innovation of the glazing and firing technology on the later development of Chinese ceramic production.
Published: 2012

41. Molecular characteristics and comparative genomics analysis of a clinical Enterococcus casseliflavus with a resistance plasmid

Author: Yin M, Jiang Y, Qian C, Wu F, Ying Y, Wu C, Li P, Ying J, Li K, Xu T, Bao Q, and Sun C
Subjects: Enterococcus casseliflavus, antimicrobial resistance, transposon, molecular characteristics, comparative genomics analysis, Infectious and parasitic diseases, RC109-216
Abstract: Min Yin,1,* Yi Jiang,1,* Changrui Qian,1 Fei Wu,1 Yuanyuan Ying,1 Chongyang Wu,1 Peizhen Li,1 Jun Ying,1 Kewei Li,1 Teng Xu,1 Qiyu Bao,1 Caixia Sun2 1Department of Microbiology and Immunology, School of Laboratory Medicine and Life Sciences/Institute of Biomedical Informatics, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; 2Nursing Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China *These authors contributed equally to this work Purpose: The aim of this work was to investigate the molecular characterization of a clinical Enterococcus casseliflavus strain with a resistance plasmid. Materials and methods: En. casseliflavus EC369 was isolated from a patient in a hospital in southern China. The minimum inhibitory concentration was found by means of the agar dilution method to determine the antimicrobial susceptibilities of the strains. Whole-genome sequencing and comparative genomics analysis were performed to analyze the mechanism of antibiotic resistance and the horizontal gene transfer of the resistance gene-related mobile genetic elements. Results: En. casseliflavus EC369 showed resistance to erythromycin, kanamycin, and streptomycin, but was susceptible to vancomycin, ampicillin, and streptothricin and other antimicrobials. There were six resistance genes (aph3′, ant6, bla, sat4, and two ermBs) carried by a transposon identified on the plasmid pEC369 and a complete resistance gene cluster of vancomycin and a tet (M) gene encoded on the chromosome. This is the first complete plasmid sequence reported in clinically isolated En. casseliflavus. The plasmid with the greatest sequence identity with pEC369 was the plasmid of Enterococcus sp. FDAARGOS_375, followed by the plasmids of Enterococcus faecium strains F12085 and pRE25, whereas the sequence with the greatest identity to the resistance genes carrying a transposon of pEC369 was on the chromosome of Staphylococcus aureus strain GD1677. Conclusion: The resistance profiles of En. casseliflavus EC369 might contribute to the resistance genes encoded on the plasmid. The fact that the most similar sequence to the transposon carrying resistance genes of pEC369 was encoded in the chromosome of a S. aureus strain provides insights into the mechanism of dissemination of multidrug resistance between bacteria of different species or genera through horizontal gene transfer. Keywords: Enterococcus casseliflavus, antimicrobial resistance, transposon, molecular characteristics, comparative genomics analysis
Published: 2018

42. Hepatocellular carcinoma-targeted effect of configurations and groups of glycyrrhetinic acid by evaluation of its derivative-modified liposomes

Author: Sun Y, Dai C, Yin M, Lu J, Hu H, and Chen D
Subjects: glycyrrhetinic acid, derivatives, liposomes, receptor competition, HCC-targeted effect, Medicine (General), R5-920
Abstract: Yuqi Sun,1,2 Chunmei Dai,1 Meilin Yin,1 Jinghua Lu,1 Haiyang Hu,2 Dawei Chen2 1School of Pharmacy, Jinzhou Medical University, Jinzhou, China; 2School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China Background: There are abundant glycyrrhetinic acid (GA) receptors on the cellular membrane of hepatocytes and hepatocellular carcinoma (HCC) cells. The receptor binding effect might be related to the structure of the guiding molecule. GA exists in two stereoisomers with C3-hydroxyl and C11-carbonyl active groups. Purpose: The objective of this study was to investigate the relationship between the HCC-targeted effect and the configurations and groups of GA.Methods and results: Different GA derivatives (18β-GA, 18α-GA, 3-acetyl-18β-GA [3-Ace-GA] and 11-deoxy-18β-GA [11-Deo-GA]) were used to investigate the targeting effect of GA’s configurations and groups on HCC cells. The EC50 values of competition to binding sites and the ratio of specific binding in HepG2 cells showed that 18β-GA and 3-Ace-GA demonstrated significant competitive effect with fluorescein isothiocyanate (FITC)-labeled GA. Then, the GA derivatives were distearoyl-phosphatidylethanolamine (DSPE)-PEGylated. 18β-GA-, 18α-GA-, 3-Ace-GA- and 11-Deo-GA-modified liposomes were prepared and characterized by size, zeta potential, encapsulation efficiency, loading capacity, leakage and membrane stability. Evaluation on the cellular location in vitro and tumor targeting in vivo was carried out. Compared to common long-circulation liposome (PEG-Lip), more 18β-GA- and 3-Ace-GA-modified liposomes aggregated around HepG2 cells in vitro in short time and transferred into HCC tumors in vivo for a longer time. Conclusion: The β-configuration hydrogen atom on C18 position of GA played the most important role on the targeting effect. C11-carbonyl and C3-hydroxy groups of GA have certain and little influence on targeting action to HCC, respectively. In general, GA might be a promising targeting molecule for the research on liver diseases and hepatoma therapy. Keywords: glycyrrhetinic acid, derivatives, liposomes, receptor competition, HCC-targeted effect
Published: 2018

43. The Dependence of the Location and Pressure Variations of the Martian Magnetic Pileup Boundary on the Interplanetary Magnetic Field: An MHD Simulation Study

Author: Wang, M., primary, Xu, K., additional, Lu, J. Y., additional, Yin, M. X., additional, Sui, H. Y., additional, Guan, Z. J., additional, and Zhang, J. Q., additional
Published: 2023
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44. Outcomes of Pharmacomechanical Catheter-directed Thrombolysis for Acute and Subacute Inferior Vena Cava Thrombosis: A Retrospective Evaluation in a Single Institution

Author: Ye, K., Qin, J., Yin, M., Liu, X., and Lu, X.
Published: 2017
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45. Post-operative Benefit of Compression Therapy after Endovenous Laser Ablation for Uncomplicated Varicose Veins: A Randomised Clinical Trial

Author: Ye, K., Wang, R., Qin, J., Yang, X., Yin, M., Liu, X., Jiang, M., and Lu, X.
Published: 2016
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46. Outcomes of Stent Placement for Chronic Occlusion of a Filter-bearing Inferior Vena Cava in Patients with Severe Post-thrombotic Syndrome

Author: Ye, K., Lu, X., Li, W., Yin, M., Liu, X., Qin, J., Liu, G., and Jiang, M.
Published: 2016
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47. Bone density and microarchitecture in hepatitis C and HIV-coinfected postmenopausal minority women

Author: T. Yin, M., RoyChoudhury, A., Nishiyama, K., Lang, T., Shah, J., Olender, S., Ferris, D. C., Zeana, C., Sharma, A., Zingman, B., Bucovsky, M., Colon, I., and Shane, E.
Published: 2018
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48. 1078 Topical administration of MDI1228, a novel pan-JAK inhibitor, effectively suppresses the development of skin inflammation in mice

Author: Liu, Y., primary, Yin, M., additional, Yang, Y., additional, and Zhang, L., additional
Published: 2023
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49. 1018 Commensal microbiota regulates hair cycling by promoting dermal adipogenesis

Author: Liu, Y., primary, Yao, Q., additional, Yin, M., additional, Jiang, K., additional, Xia, R., additional, and Zhang, L., additional
Published: 2023
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50. SPATIAL-TEMPORAL DETERMINANTS OF MDRO TRANSMISSION DYNAMICS: IMPLICATIONS FOR INFECTION CONTROL

Author: Myall, A., primary, Venkatachalam, I., additional, Philip, C., additional, Yin, M., additional, Koon, D., additional, Arora, S., additional, Yue, Y., additional, Peach, R., additional, Weiße, A., additional, Tambyah, P., additional, Chow, A., additional, Price, J., additional, Cook, A., additional, Holmes, A., additional, and Barahona, M., additional
Published: 2023
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