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Chunxiu Zhong,1,*Junhua Yin,1,*Zhidan Zheng,2 Shaohang Cai,1,3Yulin Gao41Department Of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangdong Province, People’s Republic of China; 2Department Of Infectious Diseases, Dongguan People’s Hospital, Guangdong Province, People’s Republic of China; 3Intensive Care Unit, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China; 4School of Nursing, Southern Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workAim: To evaluate fatigue in chronic hepatitis B patients and its related independent factors, as well as the relationship between fatigue and health-related quality of life (HRQoL).Materials and methods: The study enrolled 400 patients who met the selection criteria, and their sociodemographic information was collected. The 36-item Short-Form Health Survey (SF-36) and Multidimensional fatigue inventory 20 (MFI-20) were adopted to evaluate HRQoL and fatigue level.Results: Significant differences between the fatigue group and non-fatigue group were observed for the female proportion (p=0.021), height (p=0.003), and weight (p=0.010), with or without regular exercise (p=0.001). We further determined the dimensions of fatigue that were affected by these factors and found that male patients showed significantly lower results than female patients in terms of physical fatigue (p=0.048), mental fatigue (p=0.017), and reduced motivation (p=0.025). In patients who exercised regularly, the fatigue scores for the three dimensions of general fatigue (p

ObjectiveTo investigate the impact of treatment with nucleos(t)ide analogues on quality of life (QoL) in patients with chronic hepatitis B (CHB), as well as proper nursing measures. MethodsA total of 102 CHB patients who were treated in Department of Infectious Diseases, Nanfang Hospital, Southern Medical University from March 2010 to July 2014 were enrolled and divided into continuous treatment group (54 patients) and drug withdrawal group (48 patients). The 36-item short-form health survey (SF-36) was used to measure QoL. The patients in the treatment group were evaluated before treatment and at 96 weeks of treatment, and those in the drug withdrawal group were evaluated at the time of drug withdrawal and at 48 weeks after drug withdrawal. The t-test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. The logistic regression analysis was performed for univariate and multivariate analyses. ResultsCompared with before treatment, the continuous treatment group had significant increases in the scores on the domains of physiological function, role physical, bodily pain, and general health after 96 weeks of antiviral therapy (physiological function: 94.91±7.11 vs 92.13±10.58, t=-2.924,P＜0.05; role physical: 81.94±24.96 vs 71.76±34.01, t=-2.623,P＜0.05; bodily pain: 87.72±8.64 vs 82.85±12.88, t=-3.576,P＜0.05; general health: 59.63±1459 vs 53.52±16.79, t=-3.786,P＜0.05). As for psychological quality, the continuous treatment group had a significant increase in the subscale of mental health (67.30±18.94 vs 75.56±15.53, t=-3.883,P＜0.001), while there were no significant improvements in other subscales. At 48 weeks after drug withdrawal, the drug withdrawal group had significant increases in role physical (84.20±18.97 vs 72.49±24.38, t=-2.768,P＜0.05), general health (69.28±22.94 vs 56.41±18.27, t=-3.206,P＜0.05), and mental health (75.02±16.03 vs 68.94±14.07, t=-2.078,P＜0.05). The multivariate analysis showed that marital status was associated with theimprovement in QoL after antiviral therapy (odds ratio=11.61, 95%CI:2.28-59.00,P=0.003); the unmarried patients had better improvements in QoL compared with the married ones, especially physiological function (t=-2.176,P=0.034), role physical (t=-2.173,P=0.034), and role emotional (t=-2.811,P=0.007). ConclusionAntiviral therapy can improve the QoL and mental health of CHB patients. Effective psychological intervention is necessary for CHB patients, especially married CHB patients.

An enhanced non-dominated sorting genetic algorithm (NSGA-II) was applied to carry out the integer optimized design in this article. The steady simulation design was established based on the reaction kinetics analysis using Aspen Plus, and the feasible region of each optimized variable was calculated through sensitive analysis. Aiming at the total cost TAC as the objective function, the NSGA-II algorithm was used directly to obtain the Pareto optimal solutions under the constraints of feasible region of variables. The simulation results showed that the NSGA-II algorithm can effectively reduce the total cost of TAC.