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24. Advancements in understanding chicken coccidiosis: from Eimeriabiology to innovative control strategies

Author

Gao, Yang, Sun, Pei, Hu, Dandan, Tang, Xinming, Zhang, Sixin, Shi, Fangyun, Yan, Xinlei, Yan, Wenchao, Shi, Tuanyuan, Wang, Si, Zou, Jun, Yin, Guangwen, Liu, Xianyong, Dong, Hui, and Suo, Xun

Abstract

Coccidiosis, an intestinal disease caused by Eimeriaprotozoan parasites, affects various animal species, and especially poses a significant threat to the poultry industry. The current primary control methods include anticoccidial drugs and vaccines. However, emerging challenges such as drug resistance and vaccine efficacy issues are rooted in the complex life cycle and species diversification of Eimeria. In this review, we first consolidate recent breakthroughs in understanding Eimeriabiology, focusing on the parasite development and its intricate interactions with the host, notably its relationships with host immune cells and the gut microbiota. Furthermore, we provide an extensive summary of current control strategies for Eimeriainfections. This includes an in-depth analysis of anticoccidial drugs, their mechanisms of resistance, and the increasing utilization of diverse anticoccidial vaccines to combat these challenges. Finally, we highlight the latest innovative strategies leading the way in coccidiosis control. Through an exploration of cutting-edge techniques, we also provide insights into future directions for effectively combating this disease. In conclusion, the future of coccidiosis control lies in the use of a multifaceted approach, integrating advanced biological insights with innovative therapeutic strategies. This review not only serves to enhance our understanding of Eimeriabiology but also provides a valuable resource for researchers involved in developing and implementing strategies to manage and control coccidiosis, ensuring the health and productivity of poultry worldwide.

Published
2024
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26. EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression

Author

Cai, Bingjie, primary, Li, Min, additional, Zheng, Yunpeng, additional, Yin, Yakun, additional, Jin, Fangcao, additional, Li, Xuyang, additional, Dong, Juan, additional, Jiao, Xiaoyan, additional, Liu, Xiaojun, additional, Zhang, Kun, additional, Li, Dongqin, additional, Wang, Junmin, additional, and Yin, Guangwen, additional

Published
2020
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30. Up-regulated lncRNA5322 elevates MAPK1 to enhance proliferation of hair follicle stem cells as a ceRNA of microRNA-19b-3p

Author

Cai, Bingjie, Wang, Xinxin, Liu, Hongtao, Ma, Shanshan, Zhang, Kun, Zhang, Yanting, Li, Qinghua, Wang, Junmin, Yao, Minghao, Guan, Fangxia, and Yin, Guangwen

Subjects
Research Paper
Abstract

Hair follicle stem cells (HFSCs), located in the bulge region of the follicle, maintain hair follicle growth and cycling. Long non-coding RNAs (lncRNAs), non-protein coding transcripts, are widely known to play critical roles in differentiation and proliferation of stem cells. Therefore, the current study aimed to explore the regulatory roles of lncRNA5322 in HFSCs proliferation and the underlying regulatory mechanisms. Initially, the expression patterns of lncRNA5322 and microRNA-19b-3p (miR-19b-3p) in HFSCs were detected. Subsequently, gain-and loss-of-functions analyses were conducted to explore the roles of lncRNA5322, miR-19b-3p and mitogen-activated protein kinase 1 (MAPK1) in cell proliferation, colony formation and apoptosis of HFSCs, with the expression of cyclin-dependent kinase (CDK)1 and CDK2 examined. Also, the interaction relationships among lncRNA5322, miR-19b-3p and MAPK1 were explored. Furthermore, a mouse model was established to detect the roles of lncRNA5322, miR-19b-3p, and MAPK1 in wound contraction and epidermal regeneration. Over-expressed lncRNA5322 was found to promote proliferation, colony formation ability but inhibit apoptosis of HFSCs, in addition to up-regulation of the expression of CDK1 and CDK2. LncRNA5322 was found to act as a ceRNA of miR-19b-3p which directly targeted MAPK1. Furthermore, up-regulation of lncRNA5322 enhanced wound contraction and epidermal regeneration in vivo by increasing the expression of MAPK1 through functioning as a ceRNA of miR-19b-3p. In summary, the results in this study suggested that lncRNA5322 serves as a ceRNA of miR-19b-3p to elevate the expression of MAPK1, ultimately promoting HFSCs proliferation, wound contraction and epidermal regeneration of mouse model.

Published
2019

45. Immunomodulatory and therapeutic effect of lentinan in treating condyloma acuminatum

Author

Fu Shizhen, Yin Huiqing, Li Dongqin, Yu Jianbin, Yin Guangwen, and He Fucheng

Subjects
Treated group, medicine.medical_specialty, business.industry, Lentinan, Therapeutic effect, General Medicine, Condyloma Acuminatum, Gastroenterology, Peripheral blood, chemistry.chemical_compound, chemistry, Internal medicine, Medicine, business, Receptor, After treatment, CD8
Abstract

Objective: To observe the immunomodulatory and therapeutic effect of lentinan in treating condyloma acuminatum (CA).Methods: Thirty-six CA patients were randomly divided into two groups, 19 in the treated group treated with lentinan and CO2 laser irradiation, and 17 in the control group, treated with laser irradiation alone. Their T lymphocyte subsets of peripheral blood and level of serum interleukin-2 (IL-2) and soluble interleukin-2 receptor (SIL-2R) were determined before and after treatment, and the recurrence rates of the two groups were compared.Results: After treatment, in the treated group, the CD4/CD8 ratio, serum IL-2 raised and serum SIL-2R lowered significantly (P < 0.05, 0.05, 0.05 respectively) as compared with before treatment, while those parameters were not changed significantly in the control group. The recurrence rate of the treated group was lower than that of the control group.P < 0.05.Conclusion: Lentinan could modulate the cellular immunofunction of CA patients and reduce the recurrence rate of CA cases.

Published
1999
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