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During the last decade, the production and hence, the amount andthe types of exposure of hazardous chemicals have been increased in theoccupationally exposed workers. Most of these chemicals have deterious effectsin the living systems. The level of chemical exposure in the occupationalsettings and the biomonitoring of workers and also establishing the regulatoryendpoints are very important. The exposures of chemicals in the workplaces havebeen associated with the increase in allergy, organ and system disorders andcancer. Therefore, the removal of these hazardous substances or thesubstitutions of them with non-toxic ones are necessary for the protection ofworkers’ health. In a large variety of occupations such as pottery and ceramicindustry, workers may be exposed to the many chemicals mainly to crystallinesilica. Occupational exposure to crystalline silica dust is related to anincreased risk for pulmonary diseases such as silicosis, tuberculosis, chronicbronchitis and lung cancer. The genotoxic changes as assessed by comet assay infoundry and ceramic workers will be given. In the presentation, the effects ofage, smoking, alcohol and protective equipment usage on the genotoxicityparameters will also be discussed. This study was funded by a grant from The Scientific andTechnological Research Council of Turkey (Project number: 115S079 and 199S200).

Amaç: Kan bağışı yapan bireyler hepatit, sitomegalovirüs gibi değişik patojenler açısından taranmaktadır. Toksik metal düzeylerinin taranması rutin bir prosedür değildir. Bu çalışmanın amacı, maruziyeti olmayan Türk bireylerde demir, çinko ve bakır gibi eser elementlerin ve kadmiyum, kurşun gibi toksik metallerin tam kan düzeylerini saptamak ve kronik metal toksisitesi riski bulunan bireyleri tanımlamaktır. Gereç ve Yöntem: Tam kan kurşun ve kadmiyum düzeyleri grafit fırınlı atomik absorpsiyon spectrometresi ile analiz edildi. Metal düzeyleri 211 erkek kan bağışı yapan bireyin (19-55 yaş arası, 33.718.69 yıl) tam kan ve serumlarında çalışıldı. İstatistiksel analiz SPSS v16 ile gerçekleştirildi. Bulgular: Kadmiyum, kurşun, çinko, bakır ve demir düzeylerinin ortalaması sırasıyla 1.270.88 µg L-1, 25.112.44 µg L-1, 0.970.16 mg L-1, 1.100.21 mg L-1, 476.5342.41 mg L-1 idi. Sadece bakır düzeyleri ile yaş arasında istatistiksel olarak anlamlı pozitif korelasyon saptandı (p0.01). Vücut kitle indeksi ve ölçülen tüm diğer metal seviyeleri arasında önemli bir korelasyon saaptanamadı (p0.05). Sigara içimi ile kadmiyum düzeyleri istatistiksel olarak anlamlı ilişki gözlendi (p0.01). Tartışma: Sonuçlar, toksikologlara ve klinik kimyacılara insanların eser element eksikliği veya daha yüksek metal seviyelerine maruziyet hakkında bilgi sağlayabilir., Aim: Blood donors are screened for various pathogens including hepatitis and cytomegalovirus. Screening for toxic metal levels is not routine process. The aims of our study were to determine the whole blood levels of toxic metals, cadmium and lead, and levels of the trace elements iron, zinc, and copper, of non-exposed Turkish subjects and also to identify individuals living under the risk of chronic metal toxicity. Material and Method: Whole blood lead and cadmium levels were analyzed by Graphite Furnace Atomic Absorption Spectrometry. Metal levels were determined in the whole blood and serum samples of 211 male blood donors (aged 19 to 55; 33.71±8.69 years). Statistical analysis was performed by SPSSv16. Results: Average levels of cadmium, lead, zinc, copper and iron were found to be 1.27±0.88 µg L-1, 25.1±12.44 µg L-1, 0.97±0.16 mg L-1, 1.10±0.21 mg L-1, and 476.53±42.41 mg L-1, respectively. Donor age had a statistically significant positive correlation only with copper levels (p0.05). A statistically significant association was found between smoking and cadmium levels (p