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This article explores outcomes treatment and factors that mitigate treatment outcomes for youth suffering from anxiety disorders. It places a special emphasis on randomized controlled trials (RCTs) of any psychological therapy (i.e., not just CBT-based methods) using any form of delivery (including cCBT) for anxiety disorders among adolescents. According to the American Psychological Association (2002), the average age at which external manifestations of adolescence becomes clear is 11 years, the legal age of adulthood in most countries, and the age at which child and adolescent mental health services end is eighteen. The age range was determined to be 11-18 years (inclusive), and we based this on the fact that eleven was the average age at which these indicators became clear. In addition, the age range of young people attending secondary school is normally between 11 and 18; Therefore, adolescents in this age range have comparable educational and social needs and duties (Perry et al., 1993). Depression, anxiety, and somatoform disorders are all examples of what are called affective disorders or EDs (National Institute for Health and Clinical Excellence NICE, 2011). According to the Globe Health Organization (WHO, 2017), these are the most common mental illnesses worldwide, and public health systems have recorded an alarming increase in the incidence of these conditions in recent years (Chisholm et al., 2016). ). According to the findings of several scientific studies, the most effective therapy for EDs appears to be psychological treatments (Hollon et al., 2006; Joesch et al., 2011; National Institute of Health and Clinical Excellence NICE, 2011, Watts et al. , 2015). Although medication is needed for severe cases, it is often unnecessary in people with mild to moderate symptoms (Dunlop et al., 2019). In fact, research has shown that patients who receive psychotherapy have a much higher chance of a full recovery (Wells et al., 2000). Individual and group psychological therapies have traditionally been two of the most common methods used to treat EDs; however, there is no clear consensus as to whether there is a difference in their achievements between the two.

As a result of the evaluations, it has been determined that an added 20.7 million people have a drug use problem. Forty percent of these people also suffered from a second mental illness. Participants came from both developed and underdeveloped countries as part of an international study conducted by the World Health Organization (WHO). According to the findings, there is a consistent pattern of high rates of mental disorders all over the world, although there are some differences in lower rates in Asian countries (Demyttenaere et al., 2013). Similarly, a meta-analysis of twenty-seven studies involving more than 150,000 participants from sixteen different European countries found that approximately 27% of people had been diagnosed with at least one mental disorder in the past 12 months (Wittchen & Jacobi, 2005). The Institute of Medicine and National Research Council meta-analysis of more than fifty studies from community samples from around the world reported a 17% prevalence rate for one or more mental, emotional, or behavioral disorders in youth, and about half reported significant functional impairment (O'Connell, Boat, and Warner, 2009). This study focused on children and adolescents. O'Connell, Boat, and Warner (2009) conducted the study. The results of the Global Burden of Disease study show that, even though we must bear in mind, disability-adjusted life years (DALYs) associated with 'mental and behavioral disorders' increased by approximately 36% between 1990 and 2010. The study was conducted by the World Health Organization (WHO) (Murray et al., 2013). DALYs represent the total number of life years lost due to disability and the years lived with it (Murray and Lopez, 1997). In conclusion, the evidence accumulating throughout the substantial number of studies conducted in various nations shows that mental disorders are common and there are emerging numbers of individuals who meet the diagnostic criteria for a mental disorder.

Objective: Familial Mediterranean fever (FMF) is the most prevalent monogenic autoinflammatory disease worldwide. The diagnosis is primarily clinical, based on severity of the disease, and confirmed by mutations of the MEFV gene. The aim of this study was to evaluate the effect of exon-2 genotypic variants on clinical signs and symptoms and the severity of FMF in children in comparison with those with an exon-10 genotypic variant.

Dissertation, RWTH Aachen University, 2022; Aachen : RWTH Aachen University (2022). = Dissertation, RWTH Aachen University, 2022, Grain oriented electrical steels (GOES), based on the composition Fe–3 wt. %Si, are soft magnetic materials that are widely used as core material in electrical transformers. In order to achieve the required magnetic properties for minimized magnetic losses, the microstructure of GOES should consist of very large grains (up to the range of few centimetres) with sharply oriented in Goss orientation ({011}). Production of GOES is achieved by a complex industrial process chain, where abnormal growth of Goss oriented grains takes place during box annealing. Despite a century of research, the underlying mechanism that leads to the abnormal growth of Goss grains is not well understood. This limits the ability to tune the process parameters, which determine the final microstructure and texture properties, and therefore, the final magnetic properties of GOES. Understanding how Goss texture forms and how the process parameters influence the final microstructure and texture is of great interest for both academia and industry.In the present thesis, among the process parameters the influence of ageing treatment during cold rolling, which improves the final magnetic properties of GOES, is investigated by means of large-area electron backscatter diffraction (EBSD). Initially identical hot rolled sheets were cold rolled by following two different routes, namely with ageing and without ageing. Subsequently, primary recrystallization annealing was performed in a dilatometer furnace with the aim of tracking the evolution of microstructure and texture. A new approach for defining a benchmark, indicating the statistical relevance of the EBSD-based texture measurements was developed. It is based on the deviation from the perfect symmetry. Accordingly, the large area EBSD measurements were confirmed to provide enough statistics for a representative texture investigation for the heavily cold rolled and the recrystallized GOES sheets. In addition, to determine true local misorientations from the ontained EBSD results in the not-fully recrystallized samples, a new methodology was developed, where noise-corrected kernel average misorientations were calculated based on a second order polynomial relationship between the kernel average misorientations and kernel size. The obtained results revealed that ageing during cold rolling significantly influences the deformation behaviour and consequently, the recovery and recrystallization kinetics in α-fiber regions. The α-fiber regions in the cold rolled and aged material exhibit a higher shear deformation, caused by the decoration of dislocations with dissolved carbon atoms. The interaction of solutes with dislocations is promoted by ageing. The dislocation pinning leads to a hindered recovery during annealing, which finally results in a higher remaining driving force for recrystallization and more nucleation sites in the otherwise sluggishly recrystallizing α-fiber ({hkl}) grains. As a result a smaller recrystallized grain size is observed in the material that was cold rolled with ageing. The effect of ageing on the improved final magnetic properties of fully processed GOES sheet was, therefore, attributed to the smaller primary recrystallized grain size, which in turn, provides a larger driving force for Goss grain growth during the subsequent secondary recrystallization step, due to a higher total area of grain boundaries.The final part of the thesis focuses on the formation of Goss texture in grain-oriented electrical steels via abnormal grain growth. Fe–3.1 wt. % Si grain-oriented electrical steels were processed in the industry plant of Thyssenkrupp Electrical Steel GmbH according to the standard production. Correlative controlled-electron channelling contrast imaging (cECCI) and atom probe tomography (APT) experiments were performed for structural and elemental analysis of dislocations, respectively. Solute enrichment at grain boundaries were analyzed using APT for the samples taken from various steps of the production chain of GOES. The results indicated that the abnormally grown Goss-oriented grains contain very low angle grain boundaries, i.e. periodically arranged, type mixed dislocations. These sub-grain dislocations are locally enriched with solutes such as Sn, Cu, C, and more importantly, with Al, N and Mn, which belong to the composition of inhibitor particles which assist the abnormal growth of Goss-oriented grains, by suppressing normal grain growth of the matrix grains.Experimental observations regarding the segregation of Al on subgrain dislocations were supported by molecular statics (MS) simulations. Based on these findings, a new hypothesis called “Dislocation-assisted particle dissolution” is proposed to explain the abnormal grain growth of Goss-oriented grains. According to this theory, subgrain dislocations originate most probably from the shear bands and microbands that form during cold rolling. These dislocations then survive primary recrystallization, and finally assist the abnormal growth of Goss grains by aiding the dissolution of inhibitors and by diffusing and absorbing the solutes from the boundaries. As a result, boundaries of Goss-oriented grains become more mobile compared to the boundaries of matrix grains., Published by RWTH Aachen University, Aachen

Amaç: Ailesel Akdeniz ateşinin kliniğinde görülen tekrarlayan febril poliserozit atakları, MEFV genindeki mutasyonlara bağlı kontrolsüz interlökin 1-β salınımından kaynaklanmaktadır ve hastalığın seyri mutasyonlara göre değişkenlik gösterebilmektedir. Bu çalışmada R202Q gen değişiminin klinik ve laboratuvar bulguları üzerindeki etkisinin değerlendirmesi amaçlanmıştır. Gereç ve yöntem: 122 pediatrik AAA hastasının demografik, klinik ve laboratuvar verileri kıyaslanmıştır. Hastalar MEFV mutasyonlarına göre R202Q değişimini heterozigot, homozigot, ekzon-10 mutasyonları ile bileşik heterozigot bulunduranlar ve sadece ekzon-10 mutasyonu bulunduranlar olarak gruplandırılarak karşılaştırılmıştır.Bulgular: Demografik, antropometrik, klinik ve laboratuvar bulgular açısından değerlendirildiğinde, gruplar arasında herhangi bir istatistiksel anlamlı fark saptanmamıştır.Sonuç: R202Q gen değişikliğine sahip hastalarda da ekzon 10 mutasyonlu hastalar gibi tipik AAA klinik bulguları gözlenebilmektedir. Ailesel Akdeniz ateşi, genotipik ve fenotipik özelliklerinin birlikte değerlendirilmesi gereken bir hastalıktır.

This study aims to make the adaptation of Dual Career Scale to the Turkish in the Elite Athletes and to examine the dual career phenomenon by considering the views of international students- athletes. “Dual Career Scale in the Elite Athletes” is a valid, reliable and suitable for measurement tool in terms of dual career planning of athletes. 111 student-athletes have participated in this study consist of taekwondo, karate, volleyball, basketball, kickboxing, weightlifting, fencing, rugby, shooting, ice hockey, muaythai, bocce, judo, darts, handball, wrestling, table tennis, athleticism and wushu branches, 51 of them are woman (45,9), while 60 of them are man (54,1). Total 30 questions have been asked to the participants and these questions cover the demographic information (1-7), sports and university participation (8-12), the familiarities of student-athletes to dual career policies, programs, initiatives, ability to use the documents and dual career support at the personal, sports and academic levels (13-21). The student-athletes have stated that they suffered from long-term absenteeism to university courses (64,9%), missing the university courses due to training periods (60,4%), limited leisure time (59,5%) and overload due to double responsibility (46,8%) while they continue their dual careers. In addition to this, the participants have expressed that they were not familiar to the policies, programs or measures supporting the dual career process (61,3%) and that they were not aware of the dual career policies or initiatives (70,3%), and the existence of dual career policy documents (65,8%). Their responses have been collected through electronic communication tools and processed in SPSS v.25 package program.

Study Objectives: The study aimed to contribute to the research and understanding of the concept of athletic mental energy (AME), which seems to be lacking in the literature. For this purpose, the relationship between athletic mental energy and eating habits was examined in a sample of professional football players. Methods: A total of 254 professional men football players with a mean age of 24.22 +/- 4.62 years, mean of 11.50 +/- 4.50 sports ages, participated in the study. The research used The Three - Factor Eating Questionnaire (TFEQ-R18) and The Athletic Mental Energy Scale (AMES). TFEQ-R18 was developed by Kadson et al (2000) and adapted to Turkish by Kirac et al (2015). AMES was developed by Lu et al (2018) and adapted to Turkish by Yildiz et al (2020). Descriptive statistics and Simple Linear Regression Analysis methods were used in the analysis of the data obtained. The analyzes were made in the SPSS 22 package program and the significance level was taken as p

The aim of this study to use variables of banking data to demonstrate the similarities and differences between multivariate statistical analysis methods and provinces in Turkey. In this context, analyses were carried out for 81 provinces with 10 different banking indicators for 2018. As the first stage in the study, principal components analysis (TBA) was applied from multivariate statistical analysis methods, and then clustering analysis was performed using both raw data and components obtained by TBA. The results obtained in both cases were compared., Bu çalışmanın amacı, bankacılık verilerinden oluşan değişkenleri kullanarak çok değişkenli istatistiksel analiz yöntemleri ile Türkiye’deki iller arasındaki benzerlik ve farklılıkları ortaya koymaktır. Bu bağlamda 2018 yılına ilişkin 10 farklı bankacılık göstergesi ile 81 il için analizler gerçekleştirilmiştir. Çalışmada ilk aşama olarak, çok değişkenli istatistiksel analiz yöntemlerinden temel bileşenler analizi (TBA) uygulanmış, sonrasında hem ham veriler hem de TBA ile elde edilen bileşenler kullanılarak kümeleme analizi yapılmıştır. Her iki durumda elde edilen sonuçlar kıyaslanmıştır.

Üretim hatlarının paletlerle beslendiği bir dondurma fabrikasındaki mevcut sistem, değer katmayan aktiviteler oluşturarak hat başlarında yığılmalara sebep olmaktadır. Bu çalışmada, periyodik araç rotalama yöntemi kullanımış ve üretim alanında yapılan iyileştirilmelere değinilmiştir. Projenin amacı, planlaması yapılamadığından kullanılamayan üç vagonlu tren sistemi için malzemelerin hat başlarına ne miktarda, nasıl ve hangi rotada taşımasına karar veren kapsamlı bir Milk Run taşıma sistemi oluşturmaktır. Bunun yanında, hat başlarında malzemelerin stoklanması için yeni taşıma sistemi ile uyumlu tasarımlar geliştirmektir. Çalışmada, günlük üretim planını girdi olarak alan ve taşıma planı oluşturan matematiksel model geliştirilmiş ve örnek problemlerde optimal sonuca ulaşılmıştır. Programın makul bir sürede sonuç verememesinden dolayı sezgisel metotlara başvurulmuştur. İnşa sezgiseliyle başlangıç çözümü alınmış, sonrasında, benzetilmiş tavlama meta sezgisel algoritması kullanılarak elde edilen çözüm iyileştirilmiştir. Kullanıcı dostu bir arayüz ile oluşturulan ZNEC Karar Destek Sistemi, iç lojistik aktivitelerine dair birçok işlemi gerçekleştirmektedir. Golden Zone iyileştirmeleri için çizilen tasarımlardan bir kısmı firmada uygulamaya geçirilmiştir. Milk Run sistemiyle, hat başlarındaki malzeme yığılmaları %78 azaltılmış ve transpalet kullanımı ortadan kaldırılmıştır., In the current system of a leading ice cream manufacturer, the production lines are fed by transpallets and this causes overstocks at the production stations with non-value added activities. The aim of the project is to develop an extensive Milk Run distribution system for an idle three-wagon train. This system for the train decides on the when, how much and in which route to feed the production stations so that right amount of good is delivered on time. Another objective of study is to design new systems for stocking raw materials at the productions sites. A mathematical model that takes the daily production schedule as input and determines the optimal transportation plan is developed. Heuristic methods are developed to solve the mathematical model since the optimal solution can not be obtained within reasonable time limits. For this, an initial solution is obtained with a constructive heuristic, and then simulated annealing heuristic is used to improve the solution. ZNEC Decision Support System with a user-friendly interface is developed for the operation of internal logistic activities. Some sketched designs for Golden Zone improvements are put into practice by the Company. Material stocks at the stations are decreased by 78% with Milk Run system and the use of transpallets is eliminated.

Amaç: Obstruktif uyku apne sendromu (OUAS) için önemli bir semptom olan gündüz aşırı uykululuk (GAU), bireyin kognitif ve fiziksel performanslarında düşüşe, iş ve trafik kazalarına sebebiyet vermektedir. GAU'nun tespitinde ve tedavi etkinliğinin takibinde, uygulama kolaylığı ve maliyetsiz oluşu nedeniyle en sık ve yaygın kullanılan testlerin başında Epworth uykululuk ölçeği (EUÖ) yer almaktadır. Bu çalışmanın amacı OUAS hasta grubunda GAU'yu demografik ve polisomnografik verilerle tartışmak ve kullanmakta olduğumuz EUÖ'nün işlerliğinin gücünü değerlendirmektir.Gereç ve yöntem: Araştırma Ocak 2014-Şubat 2016 tarihleri arasında Dokuz Eylül Üniversitesi Tıp Fakültesi Nöroloji Anabilim Dalı Uyku Bozuklukları Polikliniği'nde polisomnografik (PSG) olarak OUAS tanısı konulmuş hastalara ait verilerin retrospektif olarak incelenmesi ile gerçekleştirilmiştir. Gündüz aşırı uykululuğun EUÖ ile değerlendirildiği erişkin yaştaki tüm hastalar çalışmaya alınmıştır. İstatistik analizleri SPSS 15 kullanılarak gerçekleştirilmiştir. Anlamlılık düzeyi olarak p

In this study, the effects have researched cutting of parameters on accelerations levels of vibration and surface quality and parameters of optimum machining have been determined. Technique of Taguchi design have used in experimental and 132, 220, 308 mm/min cutting speed, 0,05, 0,1, 0,2 mm/tooth feed rate, 1, 1,5 mm cutting depth and 1, 2, 4 the number of cutting edge have been determined as control factors. Taguchi L (2¹x3³) orthogonal array have chosen in accordance with machining parameters in experimental. Minitab 15 software with the help of evaluate the results of the experimental signal / noise (S / N) ratios have based and control the factors have been determined that the optimum level of vibration acceleration and the values of surface roughness have obtained. Influence of control factors has found with the help analysis of variance (ANOVA) on surface of quality. Results, levels of vibration and surface roughness have determined the most affected the value of feed, Bu çalışmada, frezeleme işlemlerinde kesme parametrelerinin titreşim ivme seviyesi ve yüzeykalitesi üzerindeki etkileri araştırılmış ve optimum işleme parametreleri tespit edilmiştir.Deneylerde Taguchi tasarım tekniği kullanılmış ve 132, 220, 308 mm/min kesme hızı, 0,05,0,1, 0,2 mm/tooth ilerleme, 1, 1,5 mm kesme derinliği ve 1, 2, 4 adet uç sayısı kontrolfaktörleri olarak belirlenmiştir. İşleme parametrelerine uygun olarak deneylerde Taguchi L18(2¹x3³) orthogonal dizi seçilmiştir. Deney sonuçları değerlendirilirken Minitab 15 yazılımıyardımıyla sinyal/gürültü (S/N) oranı esas alınmış ve optimum titreşim ivmesi seviyesi veyüzey pürüzlülüğü değerlerini veren kontrol faktörleri belirlenmiştir. Kontrol faktörlerininsonuçlara etkisi varyans analizi (ANOVA) yardımıyla bulunmuştur. Sonuç olarak titreşimivme seviyesi ve yüzey pürüzlülüğünün en fazla ilerleme değerinden etkilendiği tespitedilmiştir.