Search

Your search keyword '"Yilmaz, Ömer H."' showing total 324 results
Start Over Author "Yilmaz, Ömer H."
324 results on '"Yilmaz, Ömer H."'

2. Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer

Author

Schmidt, Daniel R., Gramatikov, Iva Monique T., Sheen, Allison, Williams, Christopher L., Hurwitz, Martina, Dodge, Laura E., Holupka, Edward, Kiger, III, W. S., Cornwall-Brady, Milton R., Huang, Wei, Mak, Howard H., Cormier, Kathleen S, Condon, Charlene, Dane Wittrup, K., Yilmaz, Ömer H., Stevenson, Mary Ann, Down, Julian D., Floyd, Scott R., Roper, Jatin, and Vander Heiden, Matthew G.

Published
2023
Full Text
View/download PDF

3. Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis

Author

Beyaz, Semir, Chung, Charlie, Mou, Haiwei, Bauer-Rowe, Khristian E, Xifaras, Michael E, Ergin, Ilgin, Dohnalova, Lenka, Biton, Moshe, Shekhar, Karthik, Eskiocak, Onur, Papciak, Katherine, Ozler, Kadir, Almeqdadi, Mohammad, Yueh, Brian, Fein, Miriam, Annamalai, Damodaran, Valle-Encinas, Eider, Erdemir, Aysegul, Dogum, Karoline, Shah, Vyom, Alici-Garipcan, Aybuke, Meyer, Hannah V, Özata, Deniz M, Elinav, Eran, Kucukural, Alper, Kumar, Pawan, McAleer, Jeremy P, Fox, James G, Thaiss, Christoph A, Regev, Aviv, Roper, Jatin, Orkin, Stuart H, and Yilmaz, Ömer H

Subjects
Genetics, Digestive Diseases, Cancer, Stem Cell Research, Human Genome, Stem Cell Research - Nonembryonic - Non-Human, Nutrition, 2.1 Biological and endogenous factors, Aetiology, 1.1 Normal biological development and functioning, Underpinning research, Inflammatory and immune system, Carcinogenesis, Diet, High-Fat, Epithelial Cells, Histocompatibility Antigens Class II, Humans, Intestines, MHC-II, antigen presentation, cancer, diet, high-fat diet, intestinal stem cells, microbiome, obesity, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Little is known about how interactions of diet, intestinal stem cells (ISCs), and immune cells affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the expression of the major histocompatibility complex class II (MHC class II) genes in intestinal epithelial cells, including ISCs. This decline in epithelial MHC class II expression in a HFD correlates with reduced intestinal microbiome diversity. Microbial community transfer experiments suggest that epithelial MHC class II expression is regulated by intestinal flora. Mechanistically, pattern recognition receptor (PRR) and interferon-gamma (IFNγ) signaling regulates epithelial MHC class II expression. MHC class II-negative (MHC-II-) ISCs exhibit greater tumor-initiating capacity than their MHC class II-positive (MHC-II+) counterparts upon loss of the tumor suppressor Apc coupled with a HFD, suggesting a role for epithelial MHC class II-mediated immune surveillance in suppressing tumorigenesis. ISC-specific genetic ablation of MHC class II increases tumor burden cell autonomously. Thus, HFD perturbs a microbiome-stem cell-immune cell interaction that contributes to tumor initiation in the intestine.

Published
2021

5. Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Toward Goblet Cells

Author

He, Shijie, Lei, Peng, Kang, Wenying, Cheung, Priscilla, Xu, Tao, Mana, Miyeko, Park, Chan Young, Wang, Hongyan, Imada, Shinya, Russell, Jacquelyn O., Wang, Jianxun, Wang, Ruizhi, Zhou, Ziheng, Chetal, Kashish, Stas, Eric, Mohad, Vidisha, Bruun-Rasmussen, Peter, Sadreyev, Ruslan I., Hodin, Richard A., Zhang, Yanhang, Breault, David T., Camargo, Fernando D., Yilmaz, Ömer H., Fredberg, Jeffrey J., and Saeidi, Nima

Published
2023
Full Text
View/download PDF

7. Supplementary Figure 6 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
Full Text
View/download PDF

8. Supplementary Figure 24 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
Full Text
View/download PDF

9. Supplementary Figure 5 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
Full Text
View/download PDF

10. Supplementary Figure 17 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
Full Text
View/download PDF

11. Supplementary Tables S1-S12 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
Full Text
View/download PDF

12. Supplementary Figure 9 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
Full Text
View/download PDF

13. Supplementary Figure 7 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
Full Text
View/download PDF

14. Supplementary Data 1 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
Full Text
View/download PDF

15. Data from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
Full Text
View/download PDF

16. Supplementary Figure 4 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
Full Text
View/download PDF

17. Supplementary Data 2 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
Full Text
View/download PDF

18. Supplementary Figure 8 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
Full Text
View/download PDF

19. Supplementary Figure 3 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Author

Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary

Published
2024
Full Text
View/download PDF

25. Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

Author

Pentinmikko, Nalle, Iqbal, Sharif, Mana, Miyeko, Andersson, Simon, Cognetta, III, Armand B., Suciu, Radu M., Roper, Jatin, Luopajärvi, Kalle, Markelin, Eino, Gopalakrishnan, Swetha, Smolander, Olli-Pekka, Naranjo, Santiago, Saarinen, Tuure, Juuti, Anne, Pietiläinen, Kirsi, Auvinen, Petri, Ristimäki, Ari, Gupta, Nitin, Tammela, Tuomas, Jacks, Tyler, Sabatini, David M., Cravatt, Benjamin F., Yilmaz, Ömer H., and Katajisto, Pekka

Published
2019
Full Text
View/download PDF

28. Data from Transcriptome-wide In Vitro Effects of Aspirin on Patient-derived Normal Colon Organoids

Author

Devall, Matthew A.M., primary, Drew, David A., primary, Dampier, Christopher H., primary, Plummer, Sarah J., primary, Eaton, Stephen, primary, Bryant, Jennifer, primary, Díez-Obrero, Virginia, primary, Mo, Jiancheng, primary, Kedrin, Dmitriy, primary, Zerjav, Dylan C., primary, Takacsi-Nagy, Oliver, primary, Jennelle, Lucas T., primary, Ali, Mourad W., primary, Yilmaz, Ömer H., primary, Moreno, Victor, primary, Powell, Steven M., primary, Chan, Andrew T., primary, Peters, Ulrike, primary, and Casey, Graham, primary

Published
2023
Full Text
View/download PDF

29. Supplementary Data from Transcriptome-wide In Vitro Effects of Aspirin on Patient-derived Normal Colon Organoids

Author

Devall, Matthew A.M., primary, Drew, David A., primary, Dampier, Christopher H., primary, Plummer, Sarah J., primary, Eaton, Stephen, primary, Bryant, Jennifer, primary, Díez-Obrero, Virginia, primary, Mo, Jiancheng, primary, Kedrin, Dmitriy, primary, Zerjav, Dylan C., primary, Takacsi-Nagy, Oliver, primary, Jennelle, Lucas T., primary, Ali, Mourad W., primary, Yilmaz, Ömer H., primary, Moreno, Victor, primary, Powell, Steven M., primary, Chan, Andrew T., primary, Peters, Ulrike, primary, and Casey, Graham, primary

Published
2023
Full Text
View/download PDF

30. Supplementary Figure from Transcriptome-wide In Vitro Effects of Aspirin on Patient-derived Normal Colon Organoids

Author

Devall, Matthew A.M., primary, Drew, David A., primary, Dampier, Christopher H., primary, Plummer, Sarah J., primary, Eaton, Stephen, primary, Bryant, Jennifer, primary, Díez-Obrero, Virginia, primary, Mo, Jiancheng, primary, Kedrin, Dmitriy, primary, Zerjav, Dylan C., primary, Takacsi-Nagy, Oliver, primary, Jennelle, Lucas T., primary, Ali, Mourad W., primary, Yilmaz, Ömer H., primary, Moreno, Victor, primary, Powell, Steven M., primary, Chan, Andrew T., primary, Peters, Ulrike, primary, and Casey, Graham, primary

Published
2023
Full Text
View/download PDF

31. Short-term post-fast refeeding enhances intestinal stemness via polyamines

Author

Imada, Shinya, Khawaled, Saleh, Shin, Heaji, Meckelmann, Sven W., Whittaker, Charles A., Corrêa, Renan Oliveira, Alquati, Chiara, Lu, Yixin, Tie, Guodong, Pradhan, Dikshant, Calibasi-Kocal, Gizem, Nascentes Melo, Luiza Martins, Allies, Gabriele, Rösler, Jonas, Wittenhofer, Pia, Krystkiewicz, Jonathan, Schmitz, Oliver J., Roper, Jatin, Vinolo, Marco Aurelio Ramirez, Ricciardiello, Luigi, Lien, Evan C., Vander Heiden, Matthew G., Shivdasani, Ramesh A., Cheng, Chia-Wei, Tasdogan, Alpaslan, and Yilmaz, Ömer H.

Abstract

For over a century, fasting regimens have improved health, lifespan and tissue regeneration in diverse organisms, including humans1–6. However, how fasting and post-fast refeeding affect adult stem cells and tumour formation has yet to be explored in depth. Here we demonstrate that post-fast refeeding increases intestinal stem cell (ISC) proliferation and tumour formation; post-fast refeeding augments the regenerative capacity of Lgr5+ISCs, and loss of the tumour suppressor gene Apcin post-fast-refed ISCs leads to a higher tumour incidence in the small intestine and colon than in the fasted or ad libitum-fed states, demonstrating that post-fast refeeding is a distinct state. Mechanistically, we discovered that robust mTORC1 induction in post-fast-refed ISCs increases protein synthesis via polyamine metabolism to drive these changes, as inhibition of mTORC1, polyamine metabolite production or protein synthesis abrogates the regenerative or tumorigenic effects of post-fast refeeding. Given our findings, fast–refeeding cycles must be carefully considered and tested when planning diet-based strategies for regeneration without increasing cancer risk, as post-fast refeeding leads to a burst in stem-cell-driven regeneration and tumorigenicity.

Published
2024
Full Text
View/download PDF

32. Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints

Author

Kong, Yi Wen, Dreaden, Erik C., Morandell, Sandra, Zhou, Wen, Dhara, Sanjeev S., Sriram, Ganapathy, Lam, Fred C., Patterson, Jesse C., Quadir, Mohiuddin, Dinh, Anh, Shopsowitz, Kevin E., Varmeh, Shohreh, Yilmaz, Ömer H., Lippard, Stephen J., Reinhardt, H. Christian, Hemann, Michael T., Hammond, Paula T., and Yaffe, Michael B.

Published
2020
Full Text
View/download PDF

34. Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

Author

Taylor, Martin S., primary, Wu, Connie, additional, Fridy, Peter C., additional, Zhang, Stephanie J., additional, Senussi, Yasmeen, additional, Wolters, Justina C., additional, Cheng, Wen-Chih, additional, Heaps, John, additional, Miller, Bryant D., additional, Mori, Kei, additional, Cohen, Limor, additional, Jiang, Hua, additional, Molloy, Kelly R., additional, Chait, Brian T., additional, Goggins, Michael, additional, Bhan, Irun, additional, Franses, Joseph W., additional, Yang, Xiaoyu, additional, Taplin, Mary-Ellen, additional, Wang, Xinan, additional, Christiani, David C., additional, Johnson, Bruce E., additional, Meyerson, Matthew, additional, Uppaluri, Ravindra, additional, Egloff, Ann Marie, additional, Denault, Elyssa N., additional, Spring, Laura M., additional, Wang, Tian-Li, additional, Shih, Ie-Ming, additional, Jung, Euihye, additional, Arora, Kshitij S., additional, Zukerberg, Lawrence R., additional, Yilmaz, Osman H., additional, Chi, Gary, additional, Norden, Bryanna L., additional, Song, Yuhui, additional, Nieman, Linda, additional, Parikh, Aparna R., additional, Strickland, Matthew, additional, Corcoran, Ryan B., additional, Mustelin, Tomas, additional, Eng, George, additional, Yilmaz, Ömer H., additional, Matulonis, Ursula A., additional, Skates, Steven J., additional, Rueda, Bo R., additional, Drapkin, Ronny, additional, Klempner, Samuel J., additional, Deshpande, Vikram, additional, Ting, David T., additional, Rout, Michael P., additional, LaCava, John, additional, Walt, David R., additional, and Burns, Kathleen H., additional

Published
2023
Full Text
View/download PDF

36. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

Author

Roper, Jatin, Tammela, Tuomas, Cetinbas, Naniye Malli, Akkad, Adam, Roghanian, Ali, Rickelt, Steffen, Almeqdadi, Mohammad, Wu, Katherine, Oberli, Matthias A, Sánchez-Rivera, Francisco J, Park, Yoona K, Liang, Xu, Eng, George, Taylor, Martin S, Azimi, Roxana, Kedrin, Dmitriy, Neupane, Rachit, Beyaz, Semir, Sicinska, Ewa T, Suarez, Yvelisse, Yoo, James, Chen, Lillian, Zukerberg, Lawrence, Katajisto, Pekka, Deshpande, Vikram, Bass, Adam J, Tsichlis, Philip N, Lees, Jacqueline, Langer, Robert, Hynes, Richard O, Chen, Jianzhu, Bhutkar, Arjun, Jacks, Tyler, and Yilmaz, Ömer H

Published
2017
Full Text
View/download PDF

38. Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation

Author

Kummerlowe, Conner, primary, Mwakamui, Simutanyi, additional, Hughes, Travis K., additional, Mulugeta, Nolawit, additional, Mudenda, Victor, additional, Besa, Ellen, additional, Zyambo, Kanekwa, additional, Shay, Jessica E. S., additional, Fleming, Ira, additional, Vukovic, Marko, additional, Doran, Ben A., additional, Aicher, Toby P., additional, Wadsworth, Marc H., additional, Bramante, Juliet Tongue, additional, Uchida, Amiko M., additional, Fardoos, Rabiah, additional, Asowata, Osaretin E., additional, Herbert, Nicholas, additional, Yilmaz, Ömer H., additional, Kløverpris, Henrik N., additional, Garber, John J., additional, Ordovas-Montañes, José, additional, Gartner, Zev J., additional, Wallach, Thomas, additional, Shalek, Alex K., additional, and Kelly, Paul, additional

Published
2022
Full Text
View/download PDF

42. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

Author

Beyaz, Semir, Mana, Miyeko D., Roper, Jatin, Kedrin, Dmitriy, Saadatpour, Assieh, Hong, Sue-Jean, Bauer-Rowe, Khristian E., Xifaras, Michael E., Akkad, Adam, Arias, Erika, Pinello, Luca, Katz, Yarden, Shinagare, Shweta, Abu-Remaileh, Monther, Mihaylova, Maria M., Lamming, Dudley W., Dogum, Rizkullah, Guo, Guoji, Bell, George W., Selig, Martin, Nielsen, G. Petur, Gupta, Nitin, Ferrone, Cristina R., Deshpande, Vikram, Yuan, Guo-Cheng, Orkin, Stuart H., Sabatini, David M., and Yilmaz, Ömer H.

Published
2016
Full Text
View/download PDF

45. Cell size is a determinant of stem cell potential during aging

Author

Lengefeld, Jette, primary, Cheng, Chia-Wei, additional, Maretich, Pema, additional, Blair, Marguerite, additional, Hagen, Hannah, additional, McReynolds, Melanie R., additional, Sullivan, Emily, additional, Majors, Kyra, additional, Roberts, Christina, additional, Kang, Joon Ho, additional, Steiner, Joachim D., additional, Miettinen, Teemu P., additional, Manalis, Scott R., additional, Antebi, Adam, additional, Morrison, Sean J., additional, Lees, Jacqueline A., additional, Boyer, Laurie A., additional, Yilmaz, Ömer H., additional, and Amon, Angelika, additional

Published
2021
Full Text
View/download PDF

46. Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine

Author

Terranova, Christopher J., primary, Stemler, Kristina M., additional, Barrodia, Praveen, additional, Jeter-Jones, Sabrina L., additional, Ge, Zhongqi, additional, de la Cruz Bonilla, Marimar, additional, Raman, Ayush, additional, Cheng, Chia-Wei, additional, Allton, Kendra L., additional, Arslan, Emre, additional, Yilmaz, Ömer H., additional, Barton, Michelle C., additional, Rai, Kunal, additional, and Piwnica-Worms, Helen, additional

Published
2021
Full Text
View/download PDF

47. Transcriptome-wide In Vitro Effects of Aspirin on Patient-derived Normal Colon Organoids

Author

Devall, Matthew A.M., primary, Drew, David A., additional, Dampier, Christopher H., additional, Plummer, Sarah J., additional, Eaton, Stephen, additional, Bryant, Jennifer, additional, Díez-Obrero, Virginia, additional, Mo, Jiancheng, additional, Kedrin, Dmitriy, additional, Zerjav, Dylan C., additional, Takacsi-Nagy, Oliver, additional, Jennelle, Lucas T., additional, Ali, Mourad W., additional, Yilmaz, Ömer H., additional, Moreno, Victor, additional, Powell, Steven M., additional, Chan, Andrew T., additional, Peters, Ulrike, additional, and Casey, Graham, additional

Published
2021
Full Text
View/download PDF

48. Fecal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) RNA Is Associated With Decreased Coronavirus Disease 2019 (COVID-19) Survival

Author

Das Adhikari, Upasana, primary, Eng, George, additional, Farcasanu, Mara, additional, Avena, Laura E, additional, Choudhary, Manish C, additional, Triant, Virginia A, additional, Flagg, Meaghan, additional, Schiff, Abigail E, additional, Gomez, Isabella, additional, Froehle, Leah M, additional, Diefenbach, Thomas J, additional, Ronsard, Larance, additional, Lingwood, Daniel, additional, Lee, Grace C, additional, Rabi, Seyed Alireza, additional, Erstad, Derek, additional, Velmahos, George, additional, Li, Jonathan Z, additional, Hodin, Richard, additional, Stone, James R, additional, Honko, Anna N, additional, Griffiths, Anthony, additional, Yilmaz, Ömer H, additional, and Kwon, Douglas S, additional

Published
2021
Full Text
View/download PDF

49. Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

Author

Beyaz, Semir, Mana, Miyeko D., Roper, Jatin, Kedrin, Dmitriy, Saadatpour, Assieh, Hong, Sue-Jean, Bauer-Rowe, Khristian E., Xifaras, Michael E., Akkad, Adam, Arias, Erika, Pinello, Luca, Katz, Yarden, Shinagare, Shweta, Abu-Remaileh, Monther, Mihaylova, Maria M., Lamming, Dudley W., Dogum, Rizkullah, Guo, Guoji, Bell, George W., Selig, Martin, Nielsen, G. Petur, Gupta, Nitin, Ferrone, Cristina R., Deshpande, Vikram, Yuan, Guo-Cheng, Orkin, Stuart H., Sabatini, David M., and Yilmaz, Ömer H.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results