96 results on '"Yihao Tian"'
Search Results
2. Enjoying the golden years: social participation and life satisfaction among Chinese older adults
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Min Wu, Dan Yang, and Yihao Tian
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aging ,older adults ,social participation ,life satisfaction ,loneliness ,Public aspects of medicine ,RA1-1270 - Abstract
IntroductionOlder adults commonly face the risk of social isolation, which poses a significant threat to their quality of life. This study explores the association between social participation and life satisfaction among older Chinese adults.MethodsData were sourced from the 2018 China Health and Retirement Longitudinal Study. Regression analysis and mediation analysis were employed to examine the relationship between social participation and life satisfaction, with a focus on the roles of loneliness and self-rated health.ResultsThe results indicate that social participation is significantly positively associated with older adults' life satisfaction. Furthermore, the positive association is more pronounced with increased diversity in social activities. Mediation analysis reveals that reductions in feelings of loneliness and improvements in health levels mediate the relationship between social participation and life satisfaction. Further analysis showed that social participation had a greater positive association among rural older adults and those lacking family companionship.DiscussionThis study provides evidence for enhancing life satisfaction among older adults and highlights the importance of diversity in social participation.
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- 2024
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3. How Resource-Exhausted Cities Get Out of the Innovation Bottom? Evidence from China
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Zihan Hu, Min Wu, Dan Yang, Tao Luo, and Yihao Tian
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resource-exhausted cities ,sustainable urban development ,urban innovation ,marketization ,China ,Agriculture - Abstract
The transformation and upgrading of resource-exhausted cities are crucial for regional sustainable development, but how to help them overcome innovation challenges remains to be explored. Based on data from 2003 to 2016, this study used a difference-in-differences (DID) method to examine the impact of China’s support policy for resource-exhausted cities on urban innovation and tests for long-term mechanisms. The results indicate that the support policy significantly enhanced regional innovation levels. The mechanism tests showed that these policies promoted urban innovation through long-term mechanisms of increasing marketization and upgrading industrial structures. Further analysis revealed that the innovation-promoting effects of the policies were more significant in resource-exhausted cities located in the eastern region, those not dependent on coal, those with a low reliance on extractive industries, and those with a favorable talent environment. The findings suggest that the government should provide policy support to achieve the transformation, upgrading, and sustainable development of resource-exhausted cities through urban innovation.
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- 2024
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4. Promoting Urban Innovation through Smart Cities: Evidence from a Quasi-Natural Experiment in China
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Mingbo Ji, Mengyun Jin, Lingyun Chen, Yuwei Liu, and Yihao Tian
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smart city ,urban innovation ,informatization ,difference-in-differences ,China ,Agriculture - Abstract
It is of great theoretical and practical significance to investigate the influence of intelligent city construction on urban innovation. Based on the data of 238 cities in China from 2006 to 2019, this paper utilizes the staggered difference-in-differences (staggered DID) model and the mediating effect model to examine the impact and mechanisms of smart city construction on urban innovation. We find that China’s smart city pilot policies significantly promote urban innovation. Mechanism analysis shows that this innovation promotion effect acts through improving urban informatization, government financial expenditure on science and technology, and the upgrading of the city’s industrial structure. Further analysis shows that smart city construction has a stronger promoting effect on innovation in cities of a larger scale, that located in the eastern region, and have a lower level of science and education. Overall, our findings provide new insights into urban innovation and objectively assess the impact of smart city construction in China.
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- 2024
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5. Gender Differences in Migrant Workers Health in China
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Yihao Tian, Yong Zhan, and Min Wu
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gender differences ,health inequalities ,China ,health insurance ,education level ,migrant workers ,Public aspects of medicine ,RA1-1270 - Abstract
Objectives: This study aimed to explore the distribution and differences in the health status of migrant workers in China by gender and age. In addition, it investigated the causes of health inequalities among them.Methods: This paper analyzes the differences in health status across age groups for migrant workers of different genders based on the data from the China Migrant Dynamic Survey in 2018. It also empirically assesses how education level and health insurance impact gender-related health inequalities.Results: The results suggest that female migrant workers in China have significantly lower health levels than males. Furthermore, these differences in health are exacerbated with age. This disparity may be attributed to lower participation in social insurance participation and less educational attainment among female migrant workers than their male counterparts.Conclusion: The government should take effective practical measures to increase the social insurance participation rate of female migrant workers. Moreover, investing in female education to reduce health inequality among migrant workers is essential.
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- 2023
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6. Evaluation on the effect of the transformation policy of resource-exhausted cities—An empirical analysis based on the difference-in-difference model
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Bin Yang, Xiaoyi Zhan, and Yihao Tian
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Resource-exhausted urban transformation ,Sustainable economic development ,Policy effect evaluation ,Difference-in-difference ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Realizing the effective transformation of resource-exhausted cities and promoting the sustainable development of these cities are part of high-quality economic development. From 2004, China promulgated a series of policies on promoting the sustainable development of resource-based cities. It is of great significance to objectively evaluate the effects of the polices for the implementation and improvement of the policy itself. Based on the panel data of 284 prefecture-level cities in China from 2003 to 2018, this study uses the policies to constructs the heterogeneous timing difference-in-difference model to evaluate the impacts of transformation policies on the economic growth of resource-exhausted cities and found that the policies have a significant role in promoting the economic growth of resource-exhausted cities, which was verified by placebo test, showing that the policy is effective, and puts forward some suggestions for the further promotion of the transformation of resource-exhausted cities.
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- 2021
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7. The role of circadian rhythm in osteoporosis; a review
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Yihao Tian and Jian Ming
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circadian rhythm ,melatonin ,osteoclast differentiation ,circadian rhythm genes ,osteoporosis ,Biology (General) ,QH301-705.5 - Abstract
Osteoporosis is characterized by a high incidence rate, with significant effects on people’s lives. The underlying mechanisms are complex, with no treatments for the condition. Recent studies have indicated that melatonin can be used to treat osteoporosis by promoting osteoblast proliferation and differentiation, and inhibiting osteoclast differentiation. Specifically, in vivo mechanisms are initiated by stabilizing biological rhythms in bone tissue. In healthy organisms, these biological rhythms are present in bone tissue, and are characterized by bone formation during the day, and bone resorption at night. When this rhythm is disrupted, osteoporosis occurs. Thus, taking appropriate medication at different times of the day could produce different effects on osteoporosis rhythms. In this review, we characterized these processes, and provided treatments and management strategies for individuals with osteoporosis.
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- 2022
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8. A Quantitative Study of Early Childhood Care and Education Services Under the Age of Three: Evidence From Sichuan Province, China
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Feng Peng, Xiaoyi Zhan, Bin Yang, and Yihao Tian
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early childhood care and education services ,qualitative method ,demand ,supply ,Sichuan China ,Public aspects of medicine ,RA1-1270 - Abstract
In China, early childhood care and education services for children under the age of three are neglected to some extent. Based on survey data from the Health Commission in Sichuan Province of China, this study analyzes the situation of early childhood care and education services in Sichuan through a qualitative method, using an analytical framework of matching the demand and supply. The findings reveal a mismatch between demand and supply of early childhood care and education services. This gap is likely to have a negative impact on children's self-development, family stability, and even the construction of national early childhood care and education service system. Drawing on the findings, suggestions for improving the mismatch between demand and supply are provided at the state, community and institution levels.
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- 2022
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9. CircRNA inhibits DNA damage repair by interacting with host gene
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Xiaolong Xu, Jingwei Zhang, Yihao Tian, Yang Gao, Xin Dong, Wenbo Chen, Xiaoning Yuan, Weinan Yin, Jinjing Xu, Ke Chen, Chunjiang He, and Lei Wei
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Breast cancer ,circRNA ,DNA damage repair ,R-loop ,Host gene ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Deregulated circular RNAs (circRNAs) are associated with the development of cancer and therapy resistance. However, functional research of circRNAs mostly focus on potential miRNA or protein binding and more potential regulation of circRNA on host gene DNA in cancers are yet to be inspected. Method We performed total RNA sequencing on clinical breast cancer samples and identified the expression patterns of circRNAs and corresponding host genes in patient blood, tumor and adjacent normal tissues. qPCR, northern blot and in situ hybridization were used to validate the dysregulation of circRNA circSMARCA5. A series of procedures including R-loop dot-blotting, DNA-RNA immunoprecipitation and mass spectrum, etc. were conducted to explore the regulation of circSMARCA5 on the transcription of exon 15 of SMARCA5. Moreover, immunofluorescence and in vivo experiments were executed to investigate the overexpression of circSMARCA5 with drug sensitivities. Results We found that circRNAs has average higher expression over its host linear genes in peripheral blood. Compared to adjacent normal tissues, circSMARCA5 is decreased in breast cancer tissues, contrary to host gene SMARCA5. The enforced expression of circSMARCA5 induced drug sensitivity of breast cancer cell lines in vitro and in vivo. Furthermore, we demonstrated that circSMARCA5 can bind to its parent gene locus, forming an R-loop, which results in transcriptional pausing at exon 15 of SMARCA5. CircSMARCA5 expression resulted in the downregulation of SMARCA5 and the production of a truncated nonfunctional protein, and the overexpression of circSMARCA5 was sufficient to improve sensitivity to cytotoxic drugs. Conclusion Our results revealed a new regulatory mechanism for circRNA on its host gene and provided evidence that circSMARCA5 may serve as a therapeutic target for drug-resistant breast cancer patients.
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- 2020
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10. The Effects of Open Innovation Based on Mergers and Acquisitions on Innovative Behavior of Enterprises: Evidence From Chinese Listed Enterprises
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Min Wu, Tao Luo, and Yihao Tian
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innovative behavior ,overseas mergers and acquisitions ,open innovation ,independent innovation ,difference-in-difference ,Psychology ,BF1-990 - Abstract
Finding the factors driving enterprise innovation behavior from multiple dimensions is of great significance for promoting enterprise innovation. Open innovation based on overseas mergers and acquisitions (M&A) has become one of the main ways for enterprises to obtain knowledge and technology. However, there is still no agreement on whether open innovation based on overseas M&A can promote innovation behavior of enterprises. Based on data from M&A transaction and enterprise patent of China’s Shanghai and Shenzhen A-share listed companies from 2011 to 2018, this study constructs a propensity score matching and difference-in-difference model from the perspective of innovation performance and innovation investment empirically studies the influence of open innovation mode based on overseas M&A on the innovation behavior of enterprises and finds that open innovation based on overseas M&A can significantly promote the innovation performance and innovation investment. Meanwhile dynamic effects test shows this promotion effect is sustainable; it reaches the maximum in the year of overseas M&A and decreases in the next two years. In addition, the impacts are heterogeneous due to enterprise ownership and enterprise technology intensity. The findings extends the scope of understanding innovation behavior of enterprises from overseas M&A and provide solid evidence of significant business implications for the promotion of entrepreneurial innovation.
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- 2022
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11. The Promotional Effect of Health Education on the Medical Service Utilization of Migrants: Evidence From China
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Yihao Tian, Tao Luo, and Yuxiao Chen
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the migrants ,health education ,medical service utilization ,medical service resources ,age heterogeneity ,education heterogeneity ,Public aspects of medicine ,RA1-1270 - Abstract
There were 376 million migrants in China by 2020, who made significant contributions to urban development. However, they used limited medical services and had lower self-reported health status than inflow city residents. Based on this, this study uses the cross-sectional data of the 2017 China Migrants Dynamic Survey (CMDS) to construct a multiple linear regression model to empirically study the role of health education in improving medical services utilization for migrants. It finds that compared to migrants without health education, the probability of the medical service utilization for migrants with health education has increased significantly, and counseling is more effective than other methods for health education. This promotion effect of health education has been established after a series of robustness tests. Furthermore, this study finds that the closer the migrants are to medical service resources, the greater the effect of health education on medical services utilization for migrants. The heterogeneity test shows that the effect of health education on medical services utilization for migrants is greater among the non-elderly and those with lower education levels. From the perspective of health education, the findings in this study provide empirical evidence to support the government in formulating policies to improve the utilization of medical services for migrants and reduce health inequality.
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- 2022
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12. Institutional Design and Incentives for Migrant Workers to Participate in Social Insurance in China: Evidence From a Policy Experiment in Chengdu City
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Yihao Tian, Yuxiao Chen, Mei Zhou, and Shaoyang Zhao
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social insurance ,contribution rate ,participation incentive ,migrant workers ,difference-in-difference ,Public aspects of medicine ,RA1-1270 - Abstract
Rural-to-urban migration has increased rapidly in China since the early 1980s, with the number of migrants has reached 376 million by 2020. Despite this sharp trend and the significant contributions that migrants have made to urban development, the migrant workers have had very limited access to the social insurance that the majority of urban workers enjoy. Against the background of the social insurance system adjustment in Chengdu in 2011, this study uses a difference-in-differences (DID) model to empirically test the impacts of changes in the social insurance policy contribution rates on the social insurance participation rates of migrant workers, using the China Migrants Dynamic Survey (CMDS) data for 2009–2016. We find that the social insurance participation rate of migrant workers was significantly reduced after they were incorporated into the urban worker insurance system. There was no significant change in the wages of migrant workers, but the working hours were increased and their consumption level decreased. In other words, simply changing the social insurance model of migrant workers from “comprehensive social insurance” to “urban employee insurance” reduces the incentives for migrant workers to participate in insurance and harms the overall welfare of migrant workers. Our study indicates that the design of the social security policy is an important reason for the lower participation rate of migrants. It is necessary to solve the problem of insufficient incentives through the targeted social security policies; primarily, the formulation of a social security policy contribution rate suitable for the migrants, and the establishment of a comprehensive social security policy and the gradual integration of the social security system.
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- 2021
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13. The Effects of Parental Migrant Work Experience on Labor Market Performance of Rural-Urban Migrants: Evidence from China
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Min Wu, Mengyun Jin, Luyao Zeng, and Yihao Tian
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parental migration ,income ,rural-urban migrants ,intergenerational transmission ,self-employment ,CMDS ,Agriculture - Abstract
With the development of China’s economy and the deepening of urbanization, the number of migrants whose parents have migrant work experience continues to rise. However, what is the long-term impact of parental migrant work experience on migrant children? Existing literature has not yet adequately answered. Based on the data from the China Migrants Dynamic Survey in 2016–2017, this article uses a multiple linear regression model to examine the impact of parental migrant work experience on the income of rural-urban migrants and its impact mechanism and heterogeneity empirically. We find that parental migrant work experience has a positive impact on the monthly income of second-generation rural-urban migrants. Specifically, compared with those whose parents had no such experience, the average monthly income of those whose parents had such experience increased significantly by 3.08% (approximately 124 yuan), and this effect was more apparent when fathers had migrant work experience. The main influencing channel comes from the significant increase in the probability of rural-urban migrants choosing self-employment. The results of the heterogeneity analysis showed that this effect was more significant in the sample of males and those with high school education and below. After a series of robustness tests, these conclusions remain valid. This work enriches the corresponding research literature and provides empirical evidence for studying the long-term effects of parents’ early experiences on their children.
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- 2022
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14. Evaluation of the Effects of the Ecological Environmental Damage Compensation System on Air Quality
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Min Wu, Yong Zhan, Yuwei Liu, and Yihao Tian
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pollution prevention and control ,policy assessment ,ecological environmental damage compensation system ,difference-in-difference ,Plant ecology ,QK900-989 - Abstract
This study constructs comprehensive panel data based on the China City Statistical Yearbook and environmental indicators disclosed by the Ministry of Ecology and Environment from 2013 to 2017, using a difference-in-difference (DID) model to empirically validate the effects of the ecological environmental damage compensation system on urban air quality, followed by a further analysis of the system’s effect mechanism, namely, how the system has generated effects on reducing environmental pollution. This study finds that: (1) the ecological environmental damage compensation system can significantly improve urban air quality, and small cities are more sensitive to the pilot policy; and (2) the main impact is that the pilot policy mechanism improved the urban pollutant treatment capacity and reduced the proportion of the secondary industry. After multiple robustness tests, this conclusion still holds. This study provides empirical evidence for fully implementing an ecological environmental damage compensation system.
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- 2022
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15. The Effects of De-Capacity Policy on Steel and Coal Firms’ Profitability: Evidence from China’s Listed Companies
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Yihao Tian, Lijin Ding, Bin Yang, and Feng Peng
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difference-in-difference ,de-capacity policy ,profitability ,overcapacity industry ,steel companies ,coal companies ,Technology - Abstract
Chinese overcapacity in the steel and coal industry has been on the rise since 2013, which leads to the misallocation of resources and decreases in production efficiency. In 2015, the Chinese central government adopted a series of de-capacity policies to resolve excess capacity and improve corporate profitability. However, there is scant evidence on the impacts of de-capacity policies on the firm profitability. Based on the data from Chinese listed companies in the steel and coal industry, this study constructs the difference-in-difference (DID) method to investigate the effects of the de-capacity policy on the profitability of listed companies in the steel and coal industry empirically. The results show that the de-capacity policy significantly increases the return on equity (ROE) of the experimental group, which is higher than that of the control group by 12.4%. That is partially because of the improvement in gross profit margin, management efficiency, and return on manpower due to the de-capacity policy. This study offers new evidence on the efficiency of China’s de-capacity policy toward the steel and coal industries through data at the enterprise level.
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- 2022
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16. Employment Management Policies for College Graduates under COVID-19 in China: Diffusion Characteristics and Core Issues
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Min Wu, Xinxin Hao, and Yihao Tian
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COVID-19 ,graduate employment ,policy diffusion ,text analysis ,Medicine - Abstract
The outbreak of COVID-19 epidemic has been having a great impact on the job market, so that graduates from all over the world are facing a more complex employment environment. Unemployment of the educated labor force often results in a waste of human capital and leads to serious economic and social problems. In the face of the impact of COVID-19, the Chinese government quickly introduced a series of employment policies for college graduates to relieve their employment pressure and create opportunities of career development. How did these employment policies for college graduates spread rapidly under the unconventional state of the COVID-19 epidemic? What are the diffusion characteristics? What are the core issues and measures? What are the differences between governments at all levels? These problems with rich connotation and research value needed to be further clarified. Based on the 72 employment support policies collected from the Chinese government network, this paper conducted a text analysis of the policies and found that in the process dimension, the employment policies of college graduates accumulated and exploded from bottom to top in the short term, and the policies diffusion followed the gradual model of “east–middle–west”. In the content dimension, there were five core issues: financial subsidies, innovation and entrepreneurship to drive employment, public institutions to absorb, optimizing public services, and lowering the support threshold. Meanwhile, there were obvious differences in the choice of policy tools, policy intensity, and implementation ideas in each region. The findings are of important significance for developed and developing countries to better respond to the impact of various emergency situations.
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- 2022
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17. Atorvastatin Improves Microenvironment to Enhance the Beneficial Effects of BMSCs Therapy in a Rabbit Model of Acute Myocardial Infarction
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Zhe Qu, Hongxin Xu, Yihao Tian, and Xuejun Jiang
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Cell survival ,Atorvastatin ,Bone marrow stem cells (BMSCs) ,Transplantation ,Acute myocardial infarction ,Cardiac function ,Apoptosis ,Physiology ,QP1-981 ,Biochemistry ,QD415-436 - Abstract
Background/Aims: To investigate the beneficial effects of atorvastatin added to the cell therapy with bone marrow-derived mesenchymal stromal cells (BMSCs) in a rabbit model of acute myocardial infarction (AMI). Methods: Rabbits were randomly divided into control group (n=10), bone marrow stem cells transplantation group (n=10), and BMSCs + atorvastatin group (n=10). AMI was established by ligating the left descending coronary artery. The left ventricular (LV) function was evaluated by echocardiography. H&E staining and Masson's Trichrome staining were performed to evaluate inflammatory cell infiltration and cardiac fibrosis. Immunohistochemistry and TUNEL were conducted to assess survival, differentiation, and apoptosis of transplanted cells and cardiomyocytes. Results: BMSCs decreased LV systolic and diastolic diameters and increased LV ejection fractions, LV fractional shortening, LV systolic pressure and LV end-diastolic pressure. Atorvastatin synergistically enhanced the BMSCs-induced improvements of ischemic cardiac dysfunction. Atorvastatin reduced inflammatory cell infiltration, cardiac fibrosis, and derangement of myocardial morphology/structure. Atorvastatin added a protective effect to cardiomyocytes against apoptotic cell death in infarct and peri-infarct areas, and also increased the survival rate of implanted BMSCs in acute myocardial ischemia. Atorvastatin also promoted cardiac differentiation of implanted BMSCs in infarct myocardium. Conclusion: Atorvastatin acts to improve the microenvironment both by synergistically enhancing the existing effects of BMSCs and by adding new therapeutic effects to BMSCs transplantation, and this combinational therapy is a superior cell/pharmacological therapeutic approach that merits future preclinical and clinical studies.
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- 2013
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18. TNF-α mediated increase of HIF-1α inhibits VASP expression, which reduces alveolar-capillary barrier function during acute lung injury (ALI).
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Mengjie Tang, Yihao Tian, Doulin Li, Jiawei Lv, Qun Li, Changchun Kuang, Pengchao Hu, Ying Wang, Jing Wang, Ke Su, and Lei Wei
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Medicine ,Science - Abstract
Acute lung injury (ALI) is an inflammatory disorder associated with reduced alveolar-capillary barrier function and increased pulmonary vascular permeability. Vasodilator-stimulated phosphoprotein (VASP) is widely associated with all types of modulations of cytoskeleton rearrangement-dependent cellular morphology and function, such as adhesion, shrinkage, and permeability. The present studies were conducted to investigate the effects and mechanisms by which tumor necrosis factor-alpha (TNF-α) increases the tight junction permeability in lung tissue associated with acute lung inflammation. After incubating A549 cells for 24 hours with different concentrations (0-100 ng/mL) of TNF-α, 0.1 to 8 ng/mL TNF-α exhibited no significant effect on cell viability compared with the 0 ng/mL TNF-α group (control group). However, 10 ng/mL and 100 ng/mL TNF-α dramatically inhibited the viability of A549 cells compared with the control group (*p
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- 2014
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19. Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes.
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Zongwen Tian, Changhua Wang, Chengjun Hu, Yihao Tian, Jinbao Liu, and Xuejun Wang
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Medicine ,Science - Abstract
Intracellular protein degradation is primarily performed by the ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway (ALP). The interplay between these two pathways has been rarely examined in intact animals and the mechanism underlying the interplay remains unclear. Hence, we sought to test in vivo and in vitro the impact of inhibition of the ALP on UPS proteolytic performance in cardiomyocytes and to explore the underlying mechanism. Transgenic mice ubiquitously expressing a surrogate UPS substrate (GFPdgn) were treated with bafilomycin-A1 (BFA) to inhibit the ALP. Myocardial and renal GFPdgn protein levels but not mRNA levels were increased at 24 hours but not 3 hours after the first injection of BFA. Myocardial protein abundance of key proteasome subunits and the activities of proteasomal peptidases were not discernibly altered by the treatment. In cultured neonatal rat ventricular myocytes (NRVMs), the surrogate UPS substrate GFPu and a control red fluorescence protein (RFP) were co-expressed to probe UPS performance. At 12 hours or 24 hours after ALP inhibition by 3-methyladenine (3-MA) or BFA, GFPu/RFP protein ratios and the protein half-life of GFPu were significantly increased, which is accompanied by increases in p62 proteins. Similar findings were obtained when ALP was inhibited genetically via silencing Atg7 or Rab7. ALP inhibition-induced increases in GFPu and p62 are co-localized in NRVMs. siRNA-mediated p62 knockdown prevented ALP inhibition from inducing GFPu accumulation in NRVMs. We conclude that in a p62-dependent fashion, ALP inhibition impairs cardiac UPS proteolytic performance in cardiomyocytes in vitro and in vivo.
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- 2014
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20. Tumor suppressor RASSF1A promoter: p53 binding and methylation.
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Yihao Tian, Yu Hou, Xiang Zhou, Hanhua Cheng, and Rongjia Zhou
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Medicine ,Science - Abstract
Oncogenes and tumor suppressors work in concert to regulate cell growth or death, which is a pair of antagonist factors for regulation of tumorigenesis. Here we show promoter characteristic of tumor suppressor RASSF1A, which revealed a p53 binding site in the distal and a GC-rich region in the proximal promoter region of RASSF1A, in despite of TATA box-less. The GC-rich region, which is ∼300 bp upstream from the RASSF1A ATG, showed the strongest promoter activity in an assay of RASSF1A-driving GFP expression. Methylation analysis of the CpG island showed that 78.57% of the GC sties were methylated in testis tumor samples compared with methylation-less in normal testis. Hypermethylation of the GC-rich region is associated with RASSF1A silencing in human testis tumors. In addition, electrophoretic mobility shift assay indicated that p53 protein bound to the RASSF1A promoter. Further chromatin immunoprecipitation confirmed p53 binding to the RASSF1A. Moreover, p53 binding to the promoter down-regulated RASSF1A expression. These results suggest that p53 protein specifically binds to the RASSF1A promoter and inhibits its expression. Our results provide new insight into the mechanism of action of tumor suppressors and may be a starting point for development of new approaches to cancer treatment.
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- 2011
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21. AI-Assisted Dynamic Modeling for Data Management in a Distributed System.
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Yihao Tian
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- 2022
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22. An Effective Model for Consumer Need Prediction Using Big Data Analytics.
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Yihao Tian
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- 2022
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23. Teaching Effect Evaluation System of Ideological and Political Teaching Based on Supervised Learning.
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Yihao Tian
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- 2022
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24. Role of coke media strategy in an adsorption-biological coupling technology for wastewater treatment performance, microbial community, and metabolic pathways features
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Chengyuan, Su, Xibing, Zhou, Pingping, Lu, Xiaoyun, Dai, Zhuxin, Chen, Bocai, Liang, Yihao, Tian, and Menglin, Chen
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Health, Toxicology and Mutagenesis ,Environmental Chemistry ,General Medicine ,Pollution - Abstract
With the increase of wastewater discharge, the requirement of wastewater treatment technology is gradually increased. How to treat wastewater economically, while making the treatment process short, easy to manage and low running cost, is the focus of attention. Adsorption-biological coupling technology could make adsorption and biodegradation complement each other, which has coupled accumulation effect. In this study, with coke as the adsorbent, the efficiency of the adsorption-biological coupling reactor on the treatment of total phosphorus (TP), chemical oxygen demand (COD), and ammonia nitrogen (NH
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- 2022
25. Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation
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Feng Li, Wenting Pan, Yihao Tian, Qian Zheng, Zelin Yang, Yulong Qiang, Zun Zhang, Jie Xiong, Xin Zhu, and Lei Wei
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BRAF is frequently mutated in various cancer types and contributes to tumorigenesis and metastasis. As an important switch in RAS signalling pathway, BRAF typically enables the activation of MEK and ERK, and its mutation significantly promotes metastasis. However, whether BRAF could stimulate metastasis in a MEK/ERK signalling-independent manner is still unknown. Herein, we found that a portion of the BRAF protein localized at the plasma membrane and that the BRAFV600E mutation led to abundant formation of filopodia, which is a hallmark of invasive cancer cells. Mechanistically, BRAF physically interacts with the pseudopod formation-related protein Vasodilator-stimulated phosphoprotein (VASP), and BRAF specifically catalyzes VASP phosphorylation at Ser157. VASP depletion or disruption of Ser157 phosphorylation preferentially reduced the motility, invasion and metastasis of tumor cells harboring oncogenic BRAF or KRAS. Moreover, in clinical cancer tissues, BRAFV600E was positively correlated with the extent of invasion, and tissues with BRAFV600E expression exhibited elevated levels of VASP Ser157 phosphorylation. Our study therefor reveals a noncanonical mechanism by which oncogenic BRAF or KRAS promotes metastasis, suggests that VASP Ser157 phosphorylation might serve as a valuable therapeutic target in BRAF or KRAS mutant cancers.
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- 2023
26. Melatonin inhibits osteoclastogenesis via <scp>RANKL</scp> / <scp>OPG</scp> suppression mediated by <scp>Rev‐Erbα</scp> in osteoblasts
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Yihao Tian and Jian Ming
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Glucose ,Osteoblasts ,Osteogenesis ,RANK Ligand ,Osteoprotegerin ,Humans ,Osteoclasts ,Osteoporosis ,Molecular Medicine ,Cell Differentiation ,Cell Biology ,Ligands ,Melatonin - Abstract
Diabetic osteoporosis is secondary osteoporosis and a serious complication of diabetes with a high incidence rate and poor prognosis. The specific mechanism of diabetic osteoporosis is unclear, and prevention and treatment options are limited. Recently, melatonin has been found to prevent and treat diabetic osteoporosis. Herein, we investigated the mechanism whereby melatonin inhibits osteoclastogenesis and identified a new target for osteoporosis treatment. We established an in vitro osteoblast-osteoclast co-culture system as a diabetic osteoporosis model. Osteoclastogenesis was determined using tartrate-resistant acid phosphatase staining and cathepsin K expression. Real-time PCR was used to ascertain expression of microRNA mir-882, targeting Rev-Erbα. Western blotting was performed to detect the expression of Rev-Erbα, receptor activator of NF-kB ligand (RANKL), and osteoprotegerin (OPG), and ELISA was utilized to analyse the secreted form of RANKL. High glucose promoted osteoclastogenesis and elevated the RANKL/OPG ratio in osteoblasts, while melatonin reversed these effects. High glucose inhibited Rev-Erbα expression, while melatonin promoted its expression. Conversely, high glucose promoted mir-882 expression, while melatonin inhibited it. We infer that melatonin inhibits RANKL expression in osteoblasts via the mir-882/Rev-Erbα axis, thus inhibiting osteoclastogenesis. Our findings provide insights into diabetic osteoporosis and identify a new therapeutic target for osteoporosis.
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- 2022
27. Exogenous melatonin prevents type 1 diabetes mellitus–induced bone loss, probably by inhibiting senescence
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Lin Tao, L. Shen, W. Da, Q. Wu, Rui Zhao, R. Zhou, Zunlei Gong, Yue Zhu, Yihao Tian, K. Wen, and Shui Qiu
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Senescence ,endocrine system ,Gene knockdown ,Small interfering RNA ,medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Streptozotocin ,Small hairpin RNA ,Melatonin ,Endocrinology ,Downregulation and upregulation ,Internal medicine ,medicine ,business ,Receptor ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
Exogenous melatonin inhibited the senescence of preosteoblast cells in type 1 diabetic (T1D) mice and those cultured in high glucose (HG) by multiple regulations. Exogenous melatonin had a protective effect on diabetic osteoporosis, which may depend on the inhibition of senescence. Senescence is thought to play an important role in the pathophysiological mechanisms underlying diabetic bone loss. Increasing evidence has shown that melatonin exerts anti-senescence effects. In this study, we investigated whether melatonin can inhibit senescence and prevent diabetic bone loss. C57BL/6 mice received a single intraperitoneal injection of 160 mg/kg streptozotocin, followed by the oral administration of melatonin or vehicle for 2 months. Then, tissues were harvested and subsequently examined. MC3T3-E1 cells were cultured under HG conditions for 7 days and then treated with melatonin or not for 24 h. Sirt1-specific siRNAs and MT1- or MT2-specific shRNA plasmids were transfected into MC3T3-E1 cells for mechanistic study. The total protein extracted from mouse femurs revealed that melatonin prevented senescence in T1D mice. The micro-CT results indicated that melatonin prevented bone loss in T1D mice. Cellular experiments indicated that melatonin administration prevented HG-induced senescence, whereas knockdown of the melatonin receptors MT1 or MT2 abolished these effects. Sirt1 expression was upregulated by melatonin administration but significantly reduced after MT1 or MT2 was knocked down. Knockdown of Sirt1 blocked the anti-senescence effects of melatonin. Additionally, melatonin promoted the expression of CDK2, CDK4, and CyclinD1, while knockdown of MT1 or MT2 abolished these effects. Furthermore, melatonin increased the expression of the polycomb repressive complex (PRC), but knockdown of MT1 or MT2 abolished these effects. Furthermore, melatonin increased the protein levels of Sirt1, PRC1/2 complex–, and cell cycle–related proteins. This work shows that melatonin protects against T1D-induced bone loss, probably by inhibiting senescence. Targeting senescence in the investigation of diabetic osteoporosis may lead to novel discoveries.
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- 2021
28. Melatonin inhibits RANKL‑induced osteoclastogenesis through the miR‑882/Rev‑erbα axis in Raw264.7 cells
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Zunlei Gong, Rui Zhao, Yihao Tian, and Yue Zhu
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0301 basic medicine ,medicine.medical_specialty ,Osteoclasts ,melatonin ,Melatonin ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Internal medicine ,Genetics ,medicine ,Cathepsin K ,Animals ,Receptor ,osteoclastogenesis ,Rev-erbα ,biology ,Activator (genetics) ,Chemistry ,RANK Ligand ,microRNA-882 ,Articles ,General Medicine ,MicroRNAs ,RAW 264.7 Cells ,030104 developmental biology ,Endocrinology ,Nuclear receptor ,Apoptosis ,RANKL ,030220 oncology & carcinogenesis ,Nuclear Receptor Subfamily 1, Group D, Member 1 ,biology.protein ,Signal Transduction ,medicine.drug - Abstract
Melatonin, secreted in a typical diurnal rhythm pattern, has been reported to prevent osteoporosis; however, its role in osteoclastogenesis remains unclear. In the present study, the ability of melatonin to inhibit receptor activator of nuclear factor‑κB ligand (RANKL)‑induced osteoclastogenesis and the associated mechanism were investigated. Raw264.7 cells were cultured with RANKL (100 ng/ml) and macrophage colony‑stimulating factor (M‑CSF; 30 ng/ml) for 7 days, and tartrate‑resistant acid phosphatase (TRAP) staining was used to detect osteoclastogenesis following treatment with melatonin. In addition, the effect of melatonin on cathepsin K and microRNA (miR)‑882 expression was investigated via western blotting and reverse transcription‑quantitative PCR. Melatonin significantly inhibited RANKL‑induced osteoclastogenesis in Raw264.7 cells. From bioinformatics analysis, it was inferred that nuclear receptor subfamily 1 group D member 1 (NR1D1/Rev‑erbα) may be a target of miR‑882. In vitro, melatonin upregulated Rev‑erbα expression and downregulated miR‑882 expression in the osteoclastogenesis model. Rev‑erbα overexpression boosted the anti‑osteoclastogenesis effects of melatonin, whereas miR‑882 partially diminished these effects. The present results indicated that the miR‑882/Rev‑erbα axis may serve a vital role in inhibiting osteoclastogenesis following RANKL and M‑CSF treatment, indicating that Rev‑erbα agonism or miR‑882 inhibition may represent mechanisms through which melatonin prevents osteoporosis.
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- 2020
29. CircRNA inhibits DNA damage repair by interacting with host gene
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Weinan Yin, Ke Chen, Xiaoning Yuan, Yang Gao, Yihao Tian, Xiaolong Xu, Jingwei Zhang, Jinjing Xu, Wenbo Chen, Chunjiang He, Xin Dong, and Lei Wei
- Subjects
0301 basic medicine ,Cancer Research ,DNA Repair ,Transcription, Genetic ,Chromosomal Proteins, Non-Histone ,R-loop ,Breast Neoplasms ,In situ hybridization ,Biology ,Models, Biological ,lcsh:RC254-282 ,03 medical and health sciences ,Exon ,0302 clinical medicine ,Breast cancer ,Downregulation and upregulation ,Transcription (biology) ,Cell Line, Tumor ,Neoplasms ,microRNA ,Humans ,DNA damage repair ,circRNA ,Northern blot ,Gene ,Adenosine Triphosphatases ,Host gene ,Research ,Epistasis, Genetic ,Exons ,RNA, Circular ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Cell biology ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,Gene Expression Regulation ,Oncology ,Drug Resistance, Neoplasm ,030220 oncology & carcinogenesis ,Nucleic Acid Conformation ,Molecular Medicine ,Female ,Cisplatin ,DNA Damage - Abstract
Background Deregulated circular RNAs (circRNAs) are associated with the development of cancer and therapy resistance. However, functional research of circRNAs mostly focus on potential miRNA or protein binding and more potential regulation of circRNA on host gene DNA in cancers are yet to be inspected. Method We performed total RNA sequencing on clinical breast cancer samples and identified the expression patterns of circRNAs and corresponding host genes in patient blood, tumor and adjacent normal tissues. qPCR, northern blot and in situ hybridization were used to validate the dysregulation of circRNA circSMARCA5. A series of procedures including R-loop dot-blotting, DNA-RNA immunoprecipitation and mass spectrum, etc. were conducted to explore the regulation of circSMARCA5 on the transcription of exon 15 of SMARCA5. Moreover, immunofluorescence and in vivo experiments were executed to investigate the overexpression of circSMARCA5 with drug sensitivities. Results We found that circRNAs has average higher expression over its host linear genes in peripheral blood. Compared to adjacent normal tissues, circSMARCA5 is decreased in breast cancer tissues, contrary to host gene SMARCA5. The enforced expression of circSMARCA5 induced drug sensitivity of breast cancer cell lines in vitro and in vivo. Furthermore, we demonstrated that circSMARCA5 can bind to its parent gene locus, forming an R-loop, which results in transcriptional pausing at exon 15 of SMARCA5. CircSMARCA5 expression resulted in the downregulation of SMARCA5 and the production of a truncated nonfunctional protein, and the overexpression of circSMARCA5 was sufficient to improve sensitivity to cytotoxic drugs. Conclusion Our results revealed a new regulatory mechanism for circRNA on its host gene and provided evidence that circSMARCA5 may serve as a therapeutic target for drug-resistant breast cancer patients.
- Published
- 2020
30. IU1 suppresses proliferation of cervical cancer cells through MDM2 degradation
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Xiaolong Xu, Yihao Tian, Lei Wei, Shuhua Yang, Kai Li, Jing Wang, Jingwei Zhang, Xiaoning Yuan, Yanqi He, and Liu Xu
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Proteasome Endopeptidase Complex ,cervical cancer ,medicine.medical_treatment ,Uterine Cervical Neoplasms ,UPS ,Protein degradation ,Applied Microbiology and Biotechnology ,Deubiquitinating enzyme ,Ubiquitin-Specific Peptidase 7 ,HeLa ,Mice ,03 medical and health sciences ,MDM2 ,Ubiquitin ,medicine ,Animals ,Humans ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Cell Proliferation ,030304 developmental biology ,0303 health sciences ,Protease ,biology ,Cell growth ,Chemistry ,Proto-Oncogene Proteins c-mdm2 ,Cell Biology ,biology.organism_classification ,USP14 ,Apoptosis ,biology.protein ,Cancer research ,IU1 ,Mdm2 ,Female ,Ubiquitin-Specific Proteases ,Lysosomes ,Ubiquitin Thiolesterase ,Research Paper ,Developmental Biology - Abstract
Previous studies have demonstrated that the antitumor potential of IU1 (a pharmacological compound), which was mediated by selective inhibition of proteasome-associated deubiquitinase ubiquitin-specific protease 14 (USP14). However, the underlying molecular mechanisms remain elusive. It has been well established that mdm2 (Murine double minute 2) gene was amplified and/or overexpressed in a variety of human neoplasms, including cervical cancer. Furthermore, MDM2 is critical to cervical cancer development and progression. Relatively studies have reported that USP15 and USP7 stabilized MDM2 protein levels by removing its ubiquitin chain. In the current study, we studied the cell proliferation status after IU1 treatment and the USP14-MDM2 protein interaction in cervical cancer cells. This study experimentally revealed that IU1 treatment reduced MDM2 protein expression in HeLa cervical cancer cells, along with the activation of autophagy-lysosomal protein degradation and promotion of ubiquitin-proteasome system (UPS) function, thereby blocked G0/G1 to S phase transition, decreased cell growth and triggered cell apoptosis. Thus, these results indicate that IU1 treatment simultaneously targets two major intracellular protein degradation systems, ubiquitin-proteasome and autophagy-lysosome systems, which leads to MDM2 degradation and contributes to the antitumor effect of IU1.
- Published
- 2020
31. The Wnt/β-catenin/VASP positive feedback loop drives cell proliferation and migration in breast cancer
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Yang Gao, Kai Li, Xiaolong Xu, Fang-fang Chen, Jingwei Zhang, Lei Wei, Yihao Tian, Yanqi He, and Wenting Pan
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0301 basic medicine ,Cancer Research ,Breast Neoplasms ,macromolecular substances ,Biology ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Cyclin D1 ,Downregulation and upregulation ,Cell Movement ,Genetics ,medicine ,Humans ,Wnt Signaling Pathway ,Molecular Biology ,Cell Proliferation ,Cell growth ,Microfilament Proteins ,Wnt signaling pathway ,TCF4 ,Phosphoproteins ,medicine.disease ,Cell biology ,030104 developmental biology ,030220 oncology & carcinogenesis ,Catenin ,Female ,Signal transduction ,Cell Adhesion Molecules - Abstract
Previous studies have shown that the main function of VASP is to regulate the cytoskeleton and play an important role in promoting tumor cell metastasis. In this study, we first reveal that VASP is located in the nucleus of breast cancer cells and elucidate a Wnt/β-catenin/VASP positive feedback loop. We identify that VASP is a target gene of Wnt/β-catenin signaling pathway, and activation of Wnt/β-catenin signaling pathway can significantly upregulate VASP protein expression, while upregulated VASP protein can in turn promote translocation of β-catenin and DVL3 proteins into the nucleus. In the nucleus, VASP, DVL3, β-catenin, and TCF4 can form VASP/DVL3/β-catenin/TCF4 protein complex, activating Wnt/β-catenin signaling pathway, and promoting the expression of target genes VASP, c-myc, and cyclin D1. Thus, our study reveals that there is a Wnt/β-catenin/VASP malignant positive feedback loop in breast cancer, which promotes the proliferation and migration of breast cancer cells, and breaking this positive feedback loop may provide new strategy for breast cancer treatment.
- Published
- 2019
32. AI-Assisted Dynamic Modeling for Data Management in a Distributed System
- Author
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Yihao Tian
- Subjects
Computer Networks and Communications - Abstract
Data management is an administrative mechanism that involves the acquisitions, validations, storage, protection, and processing of data needed by its users to ensure that data are accessible, reliable, and timely. It is a challenging task to manage protections for information properties. With the emphasis on distributed systems and Internet-accessible systems, the need for efficient information security management is increasingly important. In the paper, artificial intelligence-assisted dynamic modeling (AI-DM) is used for data management in a distributed system. Distributed processing is an effective way to enhance the efficiency of database systems. Therefore, each distributed database structure’s functionality depends significantly on its proper architecture in implementing fragmentation, allocation, and replication processes. The proposed model is a dynamically distributed internet database architecture. This suggested model enables complex decision-making on fragmentation, distribution, and duplication. It provides users with links from anywhere to the distributed database. AI-DM has an improved allocation and replication strategy where no query performance information is accessible at the initial stage of the distributed database design. AI-DM findings show that the proposed database model leads to the reliability and efficiency of the enhanced system. The final results are obtained by analyzing the dynamic modeling ratio is 87.6%, increasing decision support ratio is 88.7%, the logistic regression ratio is 84.5%, the data reliability ratio is 82.2%, and the system ratio is 93.8%.
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- 2021
33. An Effective Model for Consumer Need Prediction Using Big Data Analytics
- Author
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Yihao Tian
- Subjects
Set (abstract data type) ,Computer Networks and Communications ,business.industry ,Computer science ,Big data ,Volume (computing) ,The Internet ,Unstructured data ,business ,Data science ,Consumer behaviour - Abstract
Big data is an unstructured data set with a considerable volume, coming from various sources such as the internet, business organizations, etc., in various formats. Predicting consumer behavior is a core responsibility for most dealers. Market research can show consumer intentions; it can be a big order for a best-designed research project to penetrate the veil, protecting real customer motivations from closer scrutiny. Customer behavior usually focuses on customer data mining, and each model is structured at one stage to answer one query. Customer behavior prediction is a complex and unpredictable challenge. In this paper, advanced mathematical and big data analytical (BDA) methods to predict customer behavior. Predictive behavior analytics can provide modern marketers with multiple insights to optimize efforts in their strategies. This model goes beyond analyzing historical evidence and making the most knowledgeable assumptions about what will happen in the future using mathematical. Because the method is complex, it is quite straightforward for most customers. As a result, most consumer behavior models, so many variables that produce predictions that are usually quite accurate using big data. This paper attempts to develop a model of association rule mining to predict customers’ behavior, improve accuracy, and derive major consumer data patterns. The finding recommended BDA method improves Big data analytics usability in the organization (98.2%), risk management ratio (96.2%), operational cost (97.1%), customer feedback ratio (98.5%), and demand prediction ratio (95.2%).
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- 2021
34. The Promotional Effect of Health Education on the Medical Service Utilization of Migrants: Evidence From China
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Yihao Tian, Tao Luo, and Yuxiao Chen
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Transients and Migrants ,China ,age heterogeneity ,Public Health, Environmental and Occupational Health ,education heterogeneity ,social sciences ,Health Status Disparities ,Middle Aged ,the migrants ,Cross-Sectional Studies ,medical service resources ,medical service utilization ,behavior and behavior mechanisms ,population characteristics ,Humans ,Public aspects of medicine ,RA1-1270 ,Health Education ,geographic locations - Abstract
There were 376 million migrants in China by 2020, who made significant contributions to urban development. However, they used limited medical services and had lower self-reported health status than inflow city residents. Based on this, this study uses the cross-sectional data of the 2017 China Migrants Dynamic Survey (CMDS) to construct a multiple linear regression model to empirically study the role of health education in improving medical services utilization for migrants. It finds that compared to migrants without health education, the probability of the medical service utilization for migrants with health education has increased significantly, and counseling is more effective than other methods for health education. This promotion effect of health education has been established after a series of robustness tests. Furthermore, this study finds that the closer the migrants are to medical service resources, the greater the effect of health education on medical services utilization for migrants. The heterogeneity test shows that the effect of health education on medical services utilization for migrants is greater among the non-elderly and those with lower education levels. From the perspective of health education, the findings in this study provide empirical evidence to support the government in formulating policies to improve the utilization of medical services for migrants and reduce health inequality.
- Published
- 2021
35. A Quantitative Study of Early Childhood Care and Education Services Under the Age of Three: Evidence From Sichuan Province, China
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Feng Peng, Xiaoyi Zhan, Bin Yang, and Yihao Tian
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supply ,China ,Public Health, Environmental and Occupational Health ,demand ,Sichuan China ,Health Services ,Health Services Accessibility ,early childhood care and education services ,qualitative method ,Child, Preschool ,Surveys and Questionnaires ,Humans ,Public aspects of medicine ,RA1-1270 ,Child - Abstract
In China, early childhood care and education services for children under the age of three are neglected to some extent. Based on survey data from the Health Commission in Sichuan Province of China, this study analyzes the situation of early childhood care and education services in Sichuan through a qualitative method, using an analytical framework of matching the demand and supply. The findings reveal a mismatch between demand and supply of early childhood care and education services. This gap is likely to have a negative impact on children's self-development, family stability, and even the construction of national early childhood care and education service system. Drawing on the findings, suggestions for improving the mismatch between demand and supply are provided at the state, community and institution levels.
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- 2021
36. Institutional Design and Incentives for Migrant Workers to Participate in Social Insurance in China: Evidence From a Policy Experiment in Chengdu City
- Author
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Yuxiao Chen, Mei Zhou, Yihao Tian, and Shaoyang Zhao
- Subjects
Rural Population ,migrant workers ,China ,media_common.quotation_subject ,Public Policy ,Social Security ,Social insurance ,contribution rate ,Urban planning ,Humans ,media_common ,Original Research ,Consumption (economics) ,Transients and Migrants ,Motivation ,social insurance ,Public Health, Environmental and Occupational Health ,difference-in-difference ,Difference in differences ,Social security ,participation incentive ,Incentive ,Demographic economics ,Business ,Public Health ,Public aspects of medicine ,RA1-1270 ,Welfare - Abstract
Background: Rural-to-urban migration has increased rapidly in China since the early 1980s, with the number of migrants reaching 376 million in 2020 (National Bureau of Statistics [NBS], 2020). Despite this sharp trend and the significant contributions that the migrants have made to urban development, migrant workers have had very limited access to the social insurance that the majority of urban workers have enjoyed. Methods: Based on the background of the social insurance system adjustment in Chengdu in 2011, we establish a difference-in-differences (DID) model to empirically test the impacts of change in social insurance policy contribution rates on migrant workers' social insurance participation rates, using the China Migrants Dynamic Survey (CMDS) data from 2009-2016.Results: The social insurance participation rate of migrant workers was significantly reduced after they are incorporated into the urban worker insurance system. Meanwhile, there is no significant change in the wages of migrant workers, but the working hours became longer and the consumption level turned lower. That is to say, simply changing the social insurance model of migrant workers from "comprehensive social insurance" to "urban employee insurance" reduces the incentives for migrant workers to participate in the insurance and harm the overall welfares of migrant workers.Conclusion: The design of the social security policy is an important reason for lower participation rate of migrants. Therefore, it is necessary to solve the problem of insufficient incentives through targeted social security policies. Specifically, the first is to formulate a social security policy contribution rate suitable for the migrants. The second is to establish a comprehensive social security policy and gradually integrate the social security system.
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- 2021
37. Chlorotoxin targets ERα/VASP signaling pathway to combat breast cancer
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Kai Li, Lei Wei, Ying Wang, Peng-Chao Hu, Yanqi He, Yihao Tian, Wenting Pan, Song Han, Zun Zhang, Xiao-Long Xu, Jingwei Zhang, and Yang Gao
- Subjects
0301 basic medicine ,Cancer Research ,Estrogen receptor ,Peptide ,chemistry.chemical_compound ,Mice ,0302 clinical medicine ,Cell Movement ,skin and connective tissue diseases ,Chromatography, High Pressure Liquid ,Original Research ,Cancer Biology ,ERα ,chemistry.chemical_classification ,treatment ,Microfilament Proteins ,VASP ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Small molecule ,Gene Expression Regulation, Neoplastic ,Chlorotoxin ,Oncology ,030220 oncology & carcinogenesis ,Female ,Signal transduction ,Protein Binding ,Signal Transduction ,Charybdotoxin ,Scorpion Venoms ,lcsh:RC254-282 ,03 medical and health sciences ,chlorotoxin ,Breast cancer ,breast cancer ,In vivo ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Radiology, Nuclear Medicine and imaging ,Cell Proliferation ,business.industry ,Vasodilator-stimulated phosphoprotein ,Estrogen Receptor alpha ,medicine.disease ,Phosphoproteins ,Disease Models, Animal ,030104 developmental biology ,chemistry ,Cancer research ,business ,Cell Adhesion Molecules - Abstract
Breast cancer is one of the most common malignant tumors among women worldwide. About 70‐75% of primary breast cancers belong to estrogen receptor (ER)‐positive breast cancer. In the development of ER‐positive breast cancer, abnormal activation of the ERα pathway plays an important role and is also a key point leading to the failure of clinical endocrine therapy. In this study, we found that the small molecule peptide chlorotoxin (CTX) can significantly inhibit the proliferation, migration and invasion of breast cancer cells. In in vitro study, CTX inhibits the expression of ERα in breast cancer cells. Further studies showed that CTX can directly bind to ERα and change the protein secondary structure of its LBD domain, thereby inhibiting the ERα signaling pathway. In addition, we also found that vasodilator stimulated phosphoprotein (VASP) is a target gene of ERα signaling pathway, and CTX can inhibit breast cancer cell proliferation, migration, and invasion through ERα/VASP signaling pathway. In in vivo study, CTX significantly inhibits growth of ER overexpressing breast tumor and, more importantly, based on the mechanism of CTX interacting with ERα, we found that CTX can target ER overexpressing breast tumors in vivo. Our study reveals a new mechanism of CTX anti‐ER‐positive breast cancer, which also provides an important reference for the study of CTX anti‐ER‐related tumors.
- Published
- 2019
38. CREB1/Lin28/miR-638/VASP Interactive Network Drives the Development of Breast Cancer
- Author
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Kai Li, Yang Gao, Lei Wei, Ying Wang, Wenting Pan, Xiao-Long Xu, Jingwei Zhang, Yanqi He, Yihao Tian, and Peng-Chao Hu
- Subjects
Lin28 ,metastasis ,LIN28 ,Applied Microbiology and Biotechnology ,Metastasis ,Mice ,Protein Interaction Maps ,Cyclic AMP Response Element-Binding Protein ,0303 health sciences ,biology ,Microfilament Proteins ,RNA-Binding Proteins ,VASP ,Prognosis ,Gene Expression Regulation, Neoplastic ,Gene Knockdown Techniques ,CREB1 ,Female ,Research Paper ,miR-638 ,Mice, Nude ,Breast Neoplasms ,macromolecular substances ,CREB ,03 medical and health sciences ,breast cancer ,Breast cancer ,Biomarkers, Tumor ,medicine ,Animals ,Humans ,Molecular Biology ,Transcription factor ,Ecology, Evolution, Behavior and Systematics ,Cell Proliferation ,030304 developmental biology ,Wound Healing ,Epidermal Growth Factor ,Oncogene ,Cell growth ,business.industry ,Neoplasms, Experimental ,Cell Biology ,Phosphoproteins ,medicine.disease ,MicroRNAs ,biology.protein ,Cancer research ,business ,Cell Adhesion Molecules ,Developmental Biology - Abstract
Breast cancer is one of the most common malignant tumors worldwide. Metastasis remains the leading cause of death in breast cancer patients. Research on the mechanism of breast cancer metastasis has become a core issue in breast cancer research. Our previous series of studies have shown that VASP, as a key oncogene, plays an important role in the development of various tumors such as breast cancer. In this study, we find that miR-638 can target to inhibit VASP expression, and Lin28 acts as an RNA-binding protein to regulate the processing of miR-638, which inhibits its maturation and promotes the expression of VASP. In addition, we also find that CREB1 acts as a transcription factor that binds to the promoter of Lin28 gene and activates the Lin28/miR-638/VASP pathway. Furthermore, CREB1 can also directly bind to the promoter of VASP, and activate VASP expression, forming a CREB/Lin28/miR-638/VASP interactive network, which plays an important role in promoting cell proliferation and migration in breast cancer. Our study explained the mechanism of CREB1/Lin28/miR-638/VASP network promoting the development of breast cancer, which further elucidated the mechanism of VASP as a key oncogene, and also provided a theoretical basis for expanding new approaches to tumor biotherapy.
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- 2019
39. The Impacts of CPS Strategic Capability on the Upgrading of Chinese Manufacturing Structure under the Theory of Value Co-creation Based on the Regression Model
- Author
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Xingqiong Xu, Yihao Tian, and Shaoyang Zhao
- Subjects
Information management ,business.industry ,Computer science ,media_common.quotation_subject ,Manufacturing engineering ,Data modeling ,Value theory ,Promotion (rank) ,Manufacturing ,Value (economics) ,Co-creation ,business ,media_common ,Panel data - Abstract
Intelligent manufacturing is a new direction for the transformation and upgrading of manufacturing industry. This study constructs regression model and uses the balanced panel data of 30 provincial-level regions from 2008 to 2016 to explores the impact of the construction and promotion of intelligent manufacturing CPS strategic capabilities on the upgrading of manufacturing structure from the perspective of value co-creation theory. The empirical results show that CPS strategic capability has a significant positive impact on the elevation of the manufacturing structure, namely for every 1% increase in CPS strategic capability, the advanced level of manufacturing structure in the sample area increases by an average of 34.8%, and the impact of CPS strategic capability on the elevation is more prominent in economically developed regions and regions with a high level of manufacturing elevation. Mechanism analysis shows that CPS strategic capabilities have optimized and promoted the upgrading of manufacturing structure from five levels: information mapping capability, digital value-added capability, resource coordination capability, intelligent analysis capability and value co-creation capability. On this basis, three suggestions are summarized: increase the input of intelligent innovation, strengthen the optimization of organizational resources, improve the value co-creation ability of manufacturing enterprises, and finally realize the upgrading of manufacturing value chain.
- Published
- 2021
40. Does the High-Level Talent Introduction Policy Promote the Rise of Urban Housing Price? Evidence from 11 Cities in China
- Author
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Jingran Liu, Feng Peng, and Yihao Tian
- Subjects
Development economics ,Economics ,China - Published
- 2021
41. Ca2+/Calmodulin-Dependent Protein Kinase II Mediates Platelet-Derived Growth Factor-Induced Human Hepatic Stellate Cell Proliferation
- Author
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Ping, An, Yihao, Tian, Jingxing, Dai, Minkai, Chen, and Hesheng, Luo
- Published
- 2012
- Full Text
- View/download PDF
42. The Impact of Aging on Economic Growth Based on Health Investment and Technological Innovation: An Empirical Study from China
- Author
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Dan Li and Yihao Tian
- Subjects
Population ageing ,Empirical research ,Development economics ,Economics ,Mainstream ,Production (economics) ,Healthy aging ,Investment (macroeconomics) ,China ,Panel data - Abstract
Will aging definitely depress economic growth? Based on the panel data of 31 provinces in China from 2007 to 2017, this paper proposes research hypotheses from the perspective of health investment and technology innovation and then conducts an empirical test of fixed effects panel model based on the Cobb-Douglas production function to prove the relationship between aging and economic growth. Consistent with the mainstream literature, this paper finds that aging does have a significant negative impact on economic growth, that is, for every 1% of population aging, economic growth will decrease 0.089%, but the interaction between aging and health investment or aging and technological innovation on economic growth is significantly positive, namely 0.061%, 0.087% respectively. This means that aging can notably promote economic growth through the paths of health investment and technological innovation. Obviously, The final effect of aging on economic growth depends on the combination of negative effect and positive effect. The findings of this research suggest giving full play to the economic effects of health investment and technological innovation, so as to realize the balanced development of healthy aging, innovation leading, and economic growth.
- Published
- 2020
43. VASP is upregulated by WDR5-MYC nexus and promotes cell migration in breast cancer
- Author
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Xiaolong Xu, Yihao Tian, Fangfang Chen, Yang Gao, Jingjing Xu, Qi Jiang, Lei Wei, and Jingwei Zhang
- Subjects
macromolecular substances - Abstract
Backguroud: Breast cancer is one of the most threatening diseases for women, whose metastasis and recurrence are important causes of death in breast cancer patients. Vasodilator-stimulated phosphoprotein (VASP) is a cytoskeletal regulatory protein that promotes invasion and metastasis of tumor cells by regulating cell migration. Bioinformatics data indicated that H3K4me3, WDR5 and MYC co-enriched in the VASP promoter region. Aims: The purpose of this study is to demonstrate the regulatory function and mechanism of WDR5-MYC nexus complex on VASP in breast cancer.Method: In this present study, the expression of VASP in breast cancer and adjacent normal tissues was detected by RT-qPCR. The enrichment of H3K4me3, WDR5 and MYC on the VASP promoter was analyzed by ChIPseeker R package and verified by ChIP-PCR. The interaction of H3K4me3, WDR5 and MYC in breast cancer cells was detected by immunoprecipitation and immunofluorescence. Transcriptional activation function of MYC on VASP was detected by site-directed mutagenesis and dual fluorescence reporter system. The regulatory effect of WDR5 on breast cancer cell migration was tested by wund healing and transwell.Result: VASP is up-regulated in breast cancer tissues as compared with adjacent normal tissues. There is interaction between H3K4me3, WDR5 and MYC and co-enrichment on the VASP promoter. MYC can activate VASP transcription by binding to the VASP promoter-842 binding site. WDR5 and MYC can enhance the migration ability of breast cancer cells by up-regulating VASPConclusion: Our results suggest that WDR5-MYC nexus can activate the transcription of VASP by binding to the VASP promoter region, and promote the migration of breast cancer by up-regulating the expression level of VASP.
- Published
- 2020
44. Additional file 2 of CircRNA inhibits DNA damage repair by interacting with host gene
- Author
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Xiaolong Xu, Jingwei Zhang, Yihao Tian, Gao, Yang, Dong, Xin, Wenbo Chen, Xiaoning Yuan, Weinan Yin, Jinjing Xu, Chen, Ke, He, Chunjiang, and Wei, Lei
- Abstract
Additional file 2: Table S1. The ratio of circ-to-linear of circSMARCA5 (expression of circRNA / linear host genes) and clinical pathologic characteristics of breast cancer.
- Published
- 2020
- Full Text
- View/download PDF
45. Additional file 1 of CircRNA inhibits DNA damage repair by interacting with host gene
- Author
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Xiaolong Xu, Jingwei Zhang, Yihao Tian, Gao, Yang, Dong, Xin, Wenbo Chen, Xiaoning Yuan, Weinan Yin, Jinjing Xu, Chen, Ke, He, Chunjiang, and Wei, Lei
- Abstract
Additional file 1: Figure S1. The expression level of SMARCA5 and circSMARCA5 in blood and tisssues sample of breast cancer patients health volunteers and tisssues sample of renal cancer. Figure S2. RNA FISH showing circSMARCA5 was mainly expressed in the nucleus. Figure S3. circSMARCA5 decreases the expression of SMARCA5 in MCF-7 cells. Figure S4. The protein level of SMARCA5 in breast cancer and adjacent normal tissues. Figure S5. The expression correlation of circSMARCA5 and SMARCA5in different tumors. Figure S6. circSMARCA5 overexpression downregulated the protein levels of SMARCA5 while upregulating the truncated SMARCA5 (ΔSMARCA5) protein levels. Figure S7. Fragmented genomic DNA for DRIP-qPCR experiments. Figure S8. The secondary structure of circSMARCA5 and circSMARCA5-mut. Figure S9. circSMARCA5 has no significant effect on the proliferation and migration ability of breast cancer cells. Figure S10. The truncated protein ΔSMARCA5 is a nonfunctional protein product. Figure S11. Immunofluorescence assay using a γH2AX antibody showing that the cotransfection of ANT in circSMARCA5-overexpressing cells can abrogate γH2AX levels inducedby circSMARCA5 but the cotransfection of ANT-mut cannot. Figure S12. ANT significantly decreased the degree of colocalization between circSMARCA5 and its cognate DNA locus. Figure S13. (A) MCF-7 cells expressing control vector, circSMARCA5 or circSMARCA5-mut were treated with cisplatin or bleomycin in concentration gradient for 24 h, and CCK8 was used to measure cell viability. Figure S14. circSMARCA5 downregulate SMARCA5 and suppress DNA damage repair in Hela cell.
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- 2020
- Full Text
- View/download PDF
46. P21-activated kinase 7 (PAK7) interacts with and activates Wnt/β-catenin signaling pathway in breast cancer
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Xiao-Long Xu, Yang Gao, Jingbo Gao, Yuwen Qi, Yanqi He, Lei Wei, Liu Xu, Yihao Tian, Jingwei Zhang, Wenting Pan, Yanbin Ma, and Kai Li
- Subjects
0301 basic medicine ,Wnt/β-catenin signaling pathway ,cell migration ,P21-activated kinase 7 ,03 medical and health sciences ,breast cancer ,0302 clinical medicine ,Breast cancer ,Downregulation and upregulation ,Medicine ,skin and connective tissue diseases ,Tissue microarray ,Oncogene ,business.industry ,Kinase ,Wnt signaling pathway ,Cell migration ,medicine.disease ,cell proliferation ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,Signal transduction ,business ,Research Paper - Abstract
Background: Breast cancer is the highest incidence of tumor in women, which seriously threaten women's health. The occurrence and progression of breast cancer is linked to inactivation or downregulation of tumor suppressors, and activation or upregulation of oncogenes. However, the mechanism of PAK7 involving in the occurrence and progression of breast cancer is not yet fully understood. Methods: PAK7 expression was analyzed by RT-qPCR and immunohistochemistry and correlated with clinicopatholgical parameters in breast cancer tissue microarray. The effects of PAK7 on breast cancer cells were detected by CCK-8 assay, colon formation assay, wound healing and transwell assays, and flow cytometry. The relationship between PAK7 and Wnt/β-catenin signaling pathway was determined by western blotting, TOP/FOP flash, co-Immunoprecipitation and co-localization assays. Results: PAK7 expression was significantly increased in breast cancer tissues and positively correlated with pathological differentiation and TNM stage of breast cancer. Overexpression of PAK7 could significantly promote proliferation and migration of breast cancer cells, and inhibit apoptosis. In contrast, PAK7 knockdown significantly inhibited the proliferation and migration of breast cancer cells and promoted apoptosis. In addition, PAK7 could activate Wnt/β-catenin signaling pathway in breast cancer cells. Further study found that PAK7 could directly bind to GSK3β and β-catenin, and regulate β-catenin degradation by phosphorylating GSK3β. Conclusions: Our study demonstrated that PAK7, as an oncogene, involved in breast cancer progression by activating the Wnt/β-catenin signaling pathway, suggesting that the potential applicability of PAK7 as a target for breast cancer treatment.
- Published
- 2018
47. Meta-analysis showing that ERCC1 polymorphism is predictive of osteosarcoma prognosis
- Author
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Xun Ma, Xueyong Liu, Yihao Tian, Chunbo Deng, and Zhan Zhang
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Single-nucleotide polymorphism ,Review ,polymorphism ,03 medical and health sciences ,0302 clinical medicine ,osteosarcoma ,Internal medicine ,medicine ,ERCC ,business.industry ,Confounding ,Hazard ratio ,Odds ratio ,Confidence interval ,meta-analysis ,030104 developmental biology ,030220 oncology & carcinogenesis ,Meta-analysis ,ERCC2 ,prognosis ,ERCC1 ,business - Abstract
To investigate correlations between excision repair cross-complementation group 1 (ERCC1) and 2 (ERCC2) polymorphisms and osteosarcoma prognosis, we conducted a meta-analysis of studies published through October 2016. Studies were identified in the PubMed, ScienceDirect, Springer, and Web of Science databases using preferred reporting items for systematic reviews and meta-analyses (PRISMA). Odds ratios (ORs) or hazard ratios (HRs) and their 95% confidence intervals (CIs) for overall survival (OS), tumor response (TR), and event-free survival (EFS) were estimated. Our meta-analysis included eleven studies in which four SNPs (ERCC1 rs11615 and rs3212986, ERCC2 rs13181 and rs1799793) reportedly associated with osteosarcoma prognosis were investigated. Each of these studies scored > 6 on the Newcastle-Ottawa Scale (NOS). We found that only one SNP, ERCC1 rs11615, correlated with improved OS and TR. The HR of T vs. C for OS was 1.455 (T/C, 95% CI = 1.151–1.839, P = 0.002, I2 = 37.80%). The OR of T vs. C for good TR was 0.554 (T/C, 95% CI = 0.437–0.702, P < 0.001, I2 = 0%). Few significant outcome was observed in subgroup analyses stratified based on study characteristics with adjustments for potential confounders. Our results suggest that ERCC1 rs11615 CC is associated with a better clinical outcome. This suggests rs11615 may be a useful genetic marker for predicting osteosarcoma prognosis.
- Published
- 2017
48. Betulinic acid inhibits cell proliferation and migration in gastric cancer by targeting the NF-κB/VASP pathway
- Author
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Zun Zhang, Xiang Chen, Yang Gao, Qi Jiang, Yihao Tian, Xiaoning Yuan, Fang-fang Chen, Xiaolong Xu, Wenli Chen, Lei Wei, Weinan Yin, Jing-Jing Xu, Peng-Ju Gong, and Jingwei Zhang
- Subjects
0301 basic medicine ,Context (language use) ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Drug Delivery Systems ,Cell Movement ,Stomach Neoplasms ,Betulinic acid ,Cell Line, Tumor ,Humans ,Betulinic Acid ,Transcription factor ,Cell Proliferation ,Pharmacology ,Dose-Response Relationship, Drug ,Cell growth ,Microfilament Proteins ,NF-kappa B ,NF-κB ,Cell cycle ,Phosphoproteins ,Antineoplastic Agents, Phytogenic ,030104 developmental biology ,HEK293 Cells ,chemistry ,Apoptosis ,Cell culture ,Cancer research ,Pentacyclic Triterpenes ,Cell Adhesion Molecules ,030217 neurology & neurosurgery ,Signal Transduction - Abstract
Gastric cancer (GC) is one of the most common malignant neoplasms of the digestive system, with China leading in terms of morbidity and mortality rates. Betulinic acid (BA) is a widely-occurring pentacyclic triterpenoid that has been reported to exhibit potent anti-inflammatory, antioxidant, and antitumor activities. BA can combat tumors by inducing apoptosis, regulating cell cycle, and inhibiting autophagy, but its mechanism of action in the context of GC is unclear. A preliminary study found that higher expression of vasodilator-stimulated phosphoprotein (VASP) was correlated with migration in the GC cell line. In this study, BGC-823 cells and MNK45 cells were treated with BA for investigating its effect on the proliferation and migration of cells. Moreover, the expression of VASP and upstream signal molecules were also investigated in this background. The results showed BA could inhibit the proliferation and migration the GC cells. Furthermore, NF-κB acted as a transcription factor to upregulate VASP expression. Moreover, BA could downregulate the expression of VASP at the protein and mRNA level by inhibiting NF-κB activity. In conclusion, these results suggest that BA could inhibit the expression of VASP by negatively regulating NF-κB, thereby inhibiting the proliferation and migration of the GC cells. Our study provides a theoretical basis for exploring the molecular mechanism underlying BA-induced inhibition of proliferation and migration in GC cells.
- Published
- 2019
49. Silencing lncRNA SNHG6 suppresses proliferation and invasion of breast cancer cells through miR-26a/VASP axis
- Author
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Jingwei Zhang, Kai Li, Lei Wei, Yang Gao, Yihao Tian, Yanbin Ma, Yanqi He, Wenting Pan, Chunjiang He, and Xiaolong Xu
- Subjects
0301 basic medicine ,Breast Neoplasms ,Biology ,Pathology and Forensic Medicine ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Cell Movement ,Cell Line, Tumor ,medicine ,Gene silencing ,Humans ,Neoplasm Invasiveness ,Gene Silencing ,skin and connective tissue diseases ,Cell Proliferation ,Gene knockdown ,Competing endogenous RNA ,Microfilament Proteins ,Cell Biology ,medicine.disease ,Phosphoproteins ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,Female ,RNA, Long Noncoding ,Breast cancer cells ,Cell Adhesion Molecules - Abstract
The important role of LncRNA in the development of breast cancer is attracting more and more attention. In the previous study, we found that the expression level of LncRNA SNHG6 in breast cancer tissues and cells was significantly increased, but its mechanism in the development of breast cancer was still unclear. Our study found that knockdown of SNHG6 significantly inhibited the proliferation, migration and invasion of breast cancer cells MCF-7 and MDA-MB-231 cells. Further study showed that knockdown of SNHG6 significantly inhibited the expression level of VASP. More importantly, SNHG6 and VASP both can bind directly to miR-26a, suggesting that SNHG6 could act as a ceRNA to sponge miR-26a, thereby promoting the expression of VASP, which leading to activated proliferation, migration and invasion of breast cancer cells. Taken together, this study revealed the important role of the SNHG6/miR-26a/VASP regulatory network in the development of breast cancer, and provided a reference for exploring new pathogenesis and biomarkers of breast cancer.
- Published
- 2019
50. The influence of population agglomeration on air pollution: An empirical study based on the mediating effect model
- Author
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Yihao Tian, Bin Yang, and Lijin Ding
- Subjects
education.field_of_study ,Natural resource economics ,Economies of agglomeration ,Population ,Air pollution ,medicine.disease_cause ,Population density ,Industrialisation ,Urbanization ,Secondary sector of the economy ,medicine ,Environmental science ,education ,Air quality index - Abstract
With rapid urbanization and industrialization, the population of metropolis in China is increasing. Previous studies suggest that population agglomeration would have a significant impact on air pollution in cities. Using a panel dataset of 30 provincial capital cities during 2013-2017, as well as days of air quality equal to or above Grade II as air pollution indicators, the results show that an increase of population density will improve air quality in large cities. Through the mediation effect test, this paper found that tertiary industry is the mediation channel of population agglomeration to reduce air pollution. An increase of population density in big cities is conductive to increasing the proportion of tertiary industry, thereby reducing the proportion of seriously polluting secondary industry, and reducing air pollution.
- Published
- 2021
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