217 results on '"Yi-Chuan Chen"'
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2. Associations between vitamin A and K intake and lung function in the general US population: evidence from NHANES 2007–2012
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Yi-Chuan Chen and Ming-Szu Hung
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lung function ,vitamin A ,vitamin K ,airway obstruction ,forced ,Nutrition. Foods and food supply ,TX341-641 - Abstract
IntroductionWhile nutrition's critical role in enhancing respiratory health is acknowledged, the specific impacts of vitamins A and K on lung function remain largely unexplored. The study aimed to evaluate the relationships between vitamins A and K intake and lung function.MethodsThe cross-sectional study focused on adults aged 20–79 with utilizing data from US National Health and Nutrition Examination Survey (NHANES) 2007–2012. Lung function was assessed by measuring forced expiratory volume (FEV1), forced vital capacity (FVC), and the ratio of these two values (FEV1/FVC). Regression model was performed to determine the associations between intake of vitamins A and K and outcomes.ResultsData of 10,034 participants (representing 142,965,892 adults in the US) were analyzed. After adjusting for relevant confounders, multivariable analysis revealed 1 μg/day increase of vitamin A intake was significantly associated with 0.03 ml increased FEV1 (p = 0.004) and 0.04 ml increased forced vital capacity (FVC) (p < 0.001). In addition, 1 μg/day increase in vitamin K intake was significantly associated with 0.11 ml increased FEV1 (p = 0.022). Neither vitamin A and K intake was associated with FEV1/FVC or presence of airway obstruction.ConclusionsIn relatively healthy population of the US, greater vitamin A or K intake was independently associated with better lung function assessed by spirometry. Benefits of such vitamins for pulmonary health should be confirmed in future randomized controlled trials.
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- 2024
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3. Sex difference in the association between creatinine-to-cystatin C ratio and metabolic syndrome among Chinese adults
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Jo-Hsuan Chen, Jau-Yuan Chen, Yi-Chuan Chen, and Wen-Cheng Li
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serum creatinine-to-cystatin C ratio ,metabolic syndrome ,gender difference ,adipose tissue ,cystatin C ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
BackgroundMetabolic syndrome (MetS), characterized by central obesity, insulin resistance, dyslipidemia, and hypertension, affects 20-25% of the global population. The creatinine-to-cystatin C ratio (CCR) is an indicator of skeletal muscle mass. While CCR may play a role in MetS development, sex differences in these associations are not fully understood. Therefore, this study aimed to investigate how CCR levels are associated with MetS in a Chinese adult population, focusing on possible sex disparities.MethodWe conducted a retrospective cross-sectional analysis of 9,376 adults from Xiamen Chang Gung Hospital between 2014 to 2016. We examined the relationship between CCR and MetS, adjusting for cardiometabolic risk factors.ResultsThe prevalence of MetS was 24.7% in males and 18.0% in females. Interestingly, we observed significant sex differences in the association between CCR quartiles and MetS. Females in the lowest CCR quartile had a significantly higher risk of MetS (odds ratio=1.84). Receiver operating characteristic curve analysis revealed acceptable diagnostic power of CCR for MetS in females (area under the curve=0.65) but not in males.ConclusionOur findings suggest that CCR is an independent risk factor for MetS in females, highlighting the importance of sex-specific assessments when evaluating MetS risk.
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- 2024
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4. Exploring quantitative measures in metacognition of emotion
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Hsing-Hao Lee, Gabrielle Kaili-May Liu, Yi-Chuan Chen, and Su-Ling Yeh
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Medicine ,Science - Abstract
Abstract Metacognition of emotion (meta-emotion) refers to the ability to evaluate and identify one’s emotional feelings. No previous study has defined and measured this construct through objective and quantitative procedures. We established a reliable method to measure meta-emotion. With a two-interval forced-choice procedure, participants selected which of two pictures elicited stronger positive emotion; via the Law of Comparative Judgment, their responses were used to compute individual psychological distances for the emotional responses triggered by the pictures. Then, participants were asked to judge whether a pre-exposed picture induced a stronger positive emotion than the median of that elicited by the whole picture set, followed by a confidence rating. By utilizing each individual’s psychological distance, the correctness of a participant’s emotional experience was quantified by dʹ, and meta-emotion was quantified using meta-dʹ, M-ratio, and M-diff as indices of metacognitive sensitivity and efficiency based on Signal-Detection Theory. Test–retest reliabilities, validated by Spearman correlation, were observed in meta-dʹ, M-ratio, and marginally with M-diff, suggesting the stability of meta-emotion in the current design. This study unveils a validated procedure to quantify meta-emotion, extendable for assessing metacognition of other subjective feelings. Nevertheless, caution is warranted in interpretation, as the measured processes may be influenced by non-metacognitive factors.
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- 2024
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5. The development of audio–visual temporal precision precedes its rapid recalibration
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Shui’er Han, Yi-Chuan Chen, Daphne Maurer, David I. Shore, Terri L. Lewis, Brendan M. Stanley, and David Alais
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Medicine ,Science - Abstract
Abstract Through development, multisensory systems reach a balance between stability and flexibility: the systems integrate optimally cross-modal signals from the same events, while remaining adaptive to environmental changes. Is continuous intersensory recalibration required to shape optimal integration mechanisms, or does multisensory integration develop prior to recalibration? Here, we examined the development of multisensory integration and rapid recalibration in the temporal domain by re-analyzing published datasets for audio–visual, audio–tactile, and visual–tactile combinations. Results showed that children reach an adult level of precision in audio–visual simultaneity perception and show the first sign of rapid recalibration at 9 years of age. In contrast, there was very weak rapid recalibration for other cross-modal combinations at all ages, even when adult levels of temporal precision had developed. Thus, the development of audio–visual rapid recalibration appears to require the maturation of temporal precision. It may serve to accommodate distance-dependent travel time differences between light and sound.
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- 2022
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6. Gender differences in the association between insulin resistance and chronic kidney disease in a Chinese population with metabolic syndrome
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Chieh-An Lin, Wen-Cheng Li, Szu-Yu Lin, Yi-Chuan Chen, Wei Yu, Hsiung-Ying Huang, Xue-Jie Xiong, and Jau-Yuan Chen
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Chronic kidney disease ,Insulin resistance ,HOMA-IR ,Metabolic syndrome ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background Insulin resistance (IR) was reported to be associated with renal function impairment, but little is known about the gender difference. Hence, our study aimed to investigate the relationship between IR (estimated by the homeostasis model assessment of IR (HOMA-IR) index) and chronic kidney disease (CKD) in a Chinese population with metabolic syndrome (MetS) and discern whether there was any gender disparity or not. Methods This retrospective cross-sectional study enrolled 13,638 men and 10,450 women who received health examinations from 2013 to 2016 at Xiamen Chang Gung Hospital. Among the participants, 3,253 men (64.3%) and 1,808 women (35.7%) who had MetS and met the inclusion criteria were included for analysis. Spearman’s correlation was conducted to analyze the relationship between HOMA-IR and cardio-metabolic risk factors. Multivariable linear regression was analyzed to explore the relationship between HOMA-IR and cardio-metabolic variables. Logistic regression analysis was performed to assess the association between HOMA-IR and CKD. Results The median HOMA-IR and prevalence of CKD was 2.2 and 11.31%, respectively, for men and 2.09 and 15.93%, respectively, for women. In multivariable linear regression analysis, HOMA-IR was significant associated with estimated GFR, albumin/creatinine ratio in men. Multivariable logistic regression revealed a significant difference between HOMA-IR value and the prevalence of CKD in men but not in women (odds ratio in male = 1.21; 95% CI 1.14–1.28, p ≤ 0.001; odds ratio in female = 1.01; 95% CI 0.99–1.02, p = 0.38). Conclusions HOMA-IR was independently associated with CKD among men with MetS but not in women.
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- 2022
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7. Examining the automaticity and symmetry of sound–shape correspondences
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Yi-Chuan Chen and Pi-Chun Huang
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crossmodal correspondences ,implicit association test ,speeded classification task ,automatic processing ,bidirectional association ,Psychology ,BF1-990 - Abstract
IntroductionA classic example of sound–shape correspondences is the mapping of the vowel /i/ with angular patterns and the vowel /u/ with rounded patterns. Such crossmodal correspondences have been reliably reported when tested in explicit matching tasks. Nevertheless, it remains unclear whether such sound–shape correspondences automatically occur and bidirectionally modulate people’s perception. We address this question by adopting the explicit matching task and two implicit tasks.MethodsIn Experiment 1, we examined the sound–shape correspondences using the implicit association test (IAT), in which the sounds and shapes were both task-relevant, followed by an explicit matching task. In Experiments 2 and 3, we adopted the speeded classification task; when the target was a sound (or shape), a task-irrelevant shape (or sound) that was congruent or incongruent to the target was simultaneously presented. In addition, the participants performed the explicit matching task either before or after the speeded classification task.Results and DiscussionThe congruency effect was more pronounced in the IAT than in the speeded classification task; in addition, a bin analysis of RTs revealed that the congruency effect took time to develop. These findings suggest that the sound–shape correspondences were not completely automatic. The magnitude and onset of visual and auditory congruency effects were comparable, suggesting that the crossmodal modulations were symmetrical. Taken together, the sound–shape correspondences appeared not to be completely automatic, but their modulation was bidirectionally symmetrical once it occurred.
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- 2023
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8. A hospital cluster of COVID-19 associated with a SARS-CoV-2 superspreading event
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Po-Yen Huang, Ting-Shu Wu, Chun-Wen Cheng, Chih-Jung Chen, Chung-Guei Huang, Kuo-Chien Tsao, Chun-Sui Lin, Ting-Ying Chung, Chi-Chun Lai, Cheng - Ta Yang, Yi-Ching Chen, Cheng-Hsun Chiu, Li-Yueh Huang, Yueh-Pi Chiu, Kuei-Chu Hou, Mei-Lien Chen, Yu-Chuan Huang, Li-Mei Tsai, Yu-Hua Su, Hsiu-Ping Wu, Shu-Ling Liu, Hsiao-Ni Wang, Li-Fang Chang, Shu-Hui Shen, Yun-Chi Hung, En-Chi Liu, Yi-Chuan Chen, Chiu-Lan Yeh, Hsiao-Chi Chang, Yu-Ching Chen, Ya-Ting Wu, Ching-Yu Wang, Yi-Rong Lu, Mao-Cheng Ge, Jeng-How Yang, and Yen-Mu Wu
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SARS-CoV-2 ,COVID-19 ,Superspreading event ,Outbreak ,Hospital ,Microbiology ,QR1-502 - Abstract
Background/purpose: Superspreading events (SSEs) are pivotal in the spread of SARS-CoV-2. This study aimed to investigate an SSE of COVID-19 in a hospital and explore the transmission dynamics and heterogeneity of SSE. Methods: We performed contact tracing for all close contacts in a cluster. We did nasopharyngeal or throat swabbing for SARS-CoV-2 by real-time RT-PCR. Environmental survey was performed. The epidemiological and clinical characteristics of the SSE were studied. Results: Patient 1 with congestive heart failure and cellulitis, who had onset of COVID-19 two weeks after hospitalization, was the index case. Patient 1 led to 8 confirmed cases, including four health care workers (HCW). Persons tested positive for SARS-CoV-2 were HCW (n = 4), patient 1's family (n = 2), an accompanying person of an un-infected in-patient (n = 1), and an in-patient admitted before the SSE (n = 1). The attack rate among the HCW was 3.2 % (4/127). Environmental survey confirmed contamination at the bed rails, mattresses, and sink in the room patient 1 stayed, suggesting fomite transmission. The index case's sputum remained positive on illness day 35. Except one asymptomatic patient, at least three patients acquired the infection from the index case at the pre-symptomatic period. The effective reproduction number (Rt) was 0.9 (8/9). Conclusion: The host factor (heart failure, longer viral shedding), transmissibility of SARS-CoV-2 (Rt, pre-symptomatic transmission), and possible multiple modes of transmission altogether contributed to the SSE. Rapid response and advance deployment of multi-level protection in hospitals could mitigate COVID-19 transmission to one generation, thereby reducing its impact on the healthcare system.
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- 2022
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9. Association between metabolic body composition status and vitamin D deficiency: A cross-sectional study
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Yi-Chuan Chen, Wen-Cheng Li, Pin-Hsuan Ke, I-Chun Chen, Wei Yu, Hsiung-Ying Huang, Xue-Jie Xiong, and Jau-Yuan Chen
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metabolic body composition ,obesity ,vitamin D deficiency ,inflammatory marker ,cardiometabolic marker ,Nutrition. Foods and food supply ,TX341-641 - Abstract
This study aimed to investigate the risk of vitamin D deficiency in a relatively healthy Asian population, with (i) metabolically healthy normal weight (MHNW) (homeostasis model assessment-insulin resistance [HOMA-IR] < 2. 5 without metabolic syndrome [MS], body mass index [BMI] < 25), (ii) metabolically healthy obesity (MHO) (HOMA-IR < 2.5, without MS, BMI ≥ 25), (iii) metabolically unhealthy normal weight (MUNW) (HOMA-IR ≥ 2.5, or with MS, BMI < 25), and (iv) metabolically unhealthy obesity (MUO) (HOMA-IR ≥ 2.5, or with MS, BMI ≥ 25) stratified by age and sex. This cross-sectional study involved 6,655 participants aged ≥ 18 years who underwent health checkups between 2013 and 2016 at the Chang Gung Memorial Hospital. Cardiometabolic and inflammatory markers including anthropometric variables, glycemic indices, lipid profiles, high-sensitivity C-reactive protein (hs-CRP), and serum 25-hydroxy vitamin D levels, were retrospectively investigated. Compared to the MHNW group, the MHO group showed a higher odds ratio (OR) [1.35, 95% confidence interval (CI) 1.05–1.73] for vitamin D deficiency in men aged < 50 years. By contrast, in men aged > 50 years, the risk of vitamin D deficiency was higher in the MUO group (OR 1.44, 95% CI 1.05–1.97). Among women aged < and ≥ 50 years, the MUO group demonstrated the highest risk for vitamin D deficiency, OR 2.33 vs. 1.54, respectively. Our study revealed that in women of all ages and men aged > 50 years, MUO is associated with vitamin D deficiency and elevated levels of metabolic biomarkers. Among men aged < 50 years, MHO had the highest OR for vitamin D deficiency.
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- 2022
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10. Seeing Sounds: The Role of Vowels and Consonants in Crossmodal Correspondences
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Yang-Chen Shen, Yi-Chuan Chen, and Pi-Chun Huang
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Psychology ,BF1-990 - Abstract
Crossmodal correspondences refer to the fact that certain domains of features in different sensory modalities are associated with each other. Here, we investigated the crossmodal correspondences between speech sounds and visual shapes. Specifically, we tested whether the classification dimensions of English vowels (front–central–back) and consonants (voiced–voiceless, sonorant–obstruent, and stop–continuant) correspond to visual shapes along a bipolar rounded–angular dimension. We adapted eighteen meaningless pseudowords from a previous study that corresponded to either the round or the sharp concept. On each trial, the participants heard one of the pseudowords and saw a rounded shape and an angular shape presented side-by-side on the monitor. Participants judged which shape provided a better match to the spoken pseudoword. A logistic regression was conducted in order to elucidate the effectiveness of classification dimensions of phonemes when predicting variations in the sound–shape matchings. The results demonstrated that the sound–shape matchings were predictable using front–central–back dimensions of vowels, and voiced–voiceless and stop–continuant dimensions of consonants. Hence, we verified that sound–shape matching is underpinned by contrasting dimensions in both vowels and consonants, therefore demonstrating crossmodal correspondences at the phonetic level.
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- 2022
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11. Correction: Prospective Validation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score for Necrotizing Fasciitis of the Extremities.
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Cheng-Ting Hsiao, Chia-Peng Chang, Tsung-Yu Huang, Yi-Chuan Chen, and Wen-Chih Fann
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Medicine ,Science - Abstract
[This corrects the article DOI: 10.1371/journal.pone.0227748.].
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- 2022
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12. Optimal Threshold of Homeostasis Model Assessment of Insulin Resistance to Identify Metabolic Syndrome in a Chinese Population Aged 45 Years or Younger
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Szu-Yu Lin, Wen-Cheng Li, Ting-An Yang, Yi-Chuan Chen, Wei Yu, Hsiung-Ying Huang, Xue-Jie Xiong, and Jau-Yuan Chen
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metabolic syndromes ,HOMA-IR ,insulin resistance ,diabetes mellitus ,cardiovascular diseases ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
BackgroundMetabolic syndrome (MetS) is regarded as a major risk factor for diabetes mellitus and cardiovascular disease (CVD). The optimal threshold of the homeostasis model assessment of insulin resistance (HOMA-IR) has been established for predicting MetS in diverse populations and for different ages. This study assessed the serum HOMA-IR level in a healthy Chinese population aged ≤45 years to determine its relationship with metabolic abnormalities.MethodsCross-sectional study data were collected from health checkup records of Chinese adults aged ≥18 years between 2013 and 2016 at Xiamen Chang Gung Hospital. Participants completed a standardized questionnaire, which was followed by a health examination and blood sample collection. Exclusion criteria were as follows: history of known CVDs; liver, kidney, or endocrine diseases or recent acute illness; hypertension; hyperlipidemia; and pregnancy or lactation.ResultsThe clinical and laboratory characteristics of 5954 men and 4185 women were analyzed. Significant differences were observed in all assessed variables (all P < 0.05). The optimal cutoff point of HOMA-IR for predicting MetS was 1.7 in men and 1.78 in women.ConclusionsWe aimed to determine the optimal cutoff point of HOMA-IR for predicting MetS in a healthy Chinese population aged ≤45 years. The findings of this study would provide an evidence-based threshold for evaluating metabolic syndromes and further implementing primary prevention programs, such as lifestyle changes in the target population.
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- 2022
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13. Prospective Validation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score for Necrotizing Fasciitis of the Extremities.
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Cheng-Ting Hsiao, Chia-Peng Chang, Tsung-Yu Huang, Yi-Chuan Chen, and Wen-Chih Fann
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Medicine ,Science - Abstract
ObjectivesThe Laboratory Risk Indicator for Necrotizing Fasciitis score was developed as a clinical decision tool for distinguishing necrotizing fasciitis from other soft tissue infections. We prospectively evaluated the performance of the Laboratory Risk Indicator for Necrotizing Fasciitis score for the diagnosis of patients with necrotizing fasciitis in the extremities.MethodsWe conducted a prospective and observational cohort study of emergency department patients with necrotizing fasciitis or severe cellulitis in the extremities between April 2015 and December 2016. The Laboratory Risk Indicator for Necrotizing Fasciitis score was calculated for every enrolled patient. The sensitivity, specificity, positive predictive value, and negative predictive value of cut-off scores of 6 and 8 were evaluated. The accuracy of the Laboratory Risk Indicator for Necrotizing Fasciitis score was expressed as the area under the receiver operating characteristic curve.ResultsA total of 106 patients with necrotizing fasciitis and 825 patients with cellulitis were included. With an Laboratory Risk Indicator for Necrotizing Fasciitis cut-off score ≥6, the sensitivity was 43% (95% confidence interval 34% to 53%), specificity was 83% (95% confidence interval 80% to 86%), positive predictive value was 25% (95% confidence interval 20% to 30%), and negative predictive value was 92% (95% confidence interval 91% to 93%); with an Laboratory Risk Indicator for Necrotizing Fasciitis cut-off score ≥8, the sensitivity was 27% (95% confidence interval 19% to 37%), specificity was 93% (95% confidence interval 91% to 94%), positive predictive value was 33% (95% confidence interval 25% to 42%), and negative predictive value was 91% (95% confidence interval 90% to 92%). The area under the receiver operating characteristic curve for accuracy of the Laboratory Risk Indicator for Necrotizing Fasciitis score was 0.696 (95% CI 0.640 to 0.751).ConclusionThe Laboratory Risk Indicator for Necrotizing Fasciitis score may not be an accurate tool for necrotizing fasciitis risk stratification and differentiation between severe cellulitis and necrotizing fasciitis in the emergency department setting based on our study.
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- 2020
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14. Patients with Liver Cirrhosis as Frequent Attenders of Emergency Departments
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Chen-Ju Chuang, Yi-Fang Wu, Kai-Hsiang Wu, and Yi-Chuan Chen
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Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Objectives. Frequent attendance for nonemergency problems to emergency departments (EDs) contributes to ED overcrowding, resulting in medical care delays, increased medical errors, and social and economic burdens. Most studies regarding frequent attenders of EDs examine general patients without classifying certain subgroups. This study aimed to investigate patients with liver cirrhosis who present repeatedly to the ED. Methods. This was a retrospective, observational cohort study of adult patients with a history of liver cirrhosis presenting to the ED from January 2011 to December 2015. We included patients with cirrhosis whose first ED visit occurred during the study period. We went far back for 20 years and excluded patients with any ED visits (including both cirrhosis and noncirrhosis-related ones) before the study period. We categorized frequent attenders as patients with more than 4 ED visits within 12 months after the first ED visit; infrequent attenders were those who did not meet this criterion. Results. A total of 3513 patients with cirrhosis were included in this retrospective cohort study. Compared with the infrequent attenders, frequent attenders had a higher rate of presentations due to hepatic encephalopathy (15.2% vs 13.7%, P
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- 2020
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15. Comparison of Dopamine and Norepinephrine Use for the Treatment of Hypotension in Out-Of-Hospital Cardiac Arrest Patients with Return of Spontaneous Circulation
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Chao-Jui Li, Kuan-Han Wu, Chien-Chih Chen, Yat-Yin Law, Po-Chun Chuang, and Yi-Chuan Chen
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Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
In patients experiencing out-of-hospital cardiac arrest (OHCA), hypotension is common after return of spontaneous circulation (ROSC). Both dopamine and norepinephrine are recommended as inotropic therapeutic agents. This study aimed to determine the impact of the use of these two medications on hypotension. This is a multicenter retrospective cohort study. OHCA patients with ROSC were divided into three groups according to the post resuscitation inotropic agent used for treatment in the emergency department, namely, dopamine, norepinephrine, and dopamine and norepinephrine combined therapy. Thirty-day survival and favorable neurologic performance were analyzed among the three study groups. The 30-day survival and favorable neurologic performance rates in the three study groups were 12.5%, 13.0%, and 6.8% as well as 4.9%, 4.3%, and 1.2%, respectively. On controlling the potential confounding factors by logistic regression, there was no difference between dopamine and norepinephrine treatment in survival and neurologic performance (adjusted odds ratio (aOR): 1.0, 95% confidence interval (CI) 0.48–2.06; aOR: 0.8, 95% CI: 0.28–2.53). The dopamine and norepinephrine combined treatment group had worse outcome (aOR: 0.6, 95% CI: 0.35–1.18; aOR: 0.2, 95% CI: 0.05–0.89). In conclusion, there was no significant difference in post-ROSC hypotension treatment between dopamine and norepinephrine in 30-day survival and favorable neurologic performance rates.
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- 2020
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16. Different novelties revealed by infants’ pupillary responses
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Yi-Chuan Chen and Gert Westermann
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Medicine ,Science - Abstract
Abstract To account for infants’ perceptual and cognitive development, the constructivist model proposes that learning a new object depends on the capability of processing simpler lower-level units, and then integrating these units into more complex higher-level units based on their relationships, such as regular co-occurrence. Here, we demonstrate that the process of associating visual and auditory attributes to build a new multisensory object representation is not only observed in the course of development, but also in the course of infants’ in-the-moment information processing. After a brief familiarization session of learning two pairs of novel audiovisual stimuli, 15-month-old infants showed two components in pupil dilations over time: A rapid dilation was observed when processing perceptually novel compared to familiar stimuli, and a slower dilation was observed when processing novel combinations of familiar stimuli. However, in 10-month-old infants, only the effect elicited by novel stimuli was observed. Our results therefore demonstrate that detecting perceptual novelty occurred earlier than detecting association novelty in infants’ information processing. These results support the view that infants perceive newly-learned objects by processing their constituent attributes and then integrating these components, as suggested by the constructivist model.
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- 2018
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17. Characterization of a heat-tolerant Chlorella sp. GD mutant with enhanced photosynthetic CO2 fixation efficiency and its implication as lactic acid fermentation feedstock
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Tse-Min Lee, Yu-Fei Tseng, Chieh-Lun Cheng, Yi-Chuan Chen, Chih-Sheng Lin, Hsiang-Yen Su, Te-Jin Chow, Chun-Yen Chen, and Jo-Shu Chang
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Chlorella sp. ,CO2 utilization efficiency ,Lactic acid ,Light conversion efficiency ,Mutagenesis ,Photosynthesis ,Fuel ,TP315-360 ,Biotechnology ,TP248.13-248.65 - Abstract
Abstract Background Fermentative production of lactic acid from algae-based carbohydrates devoid of lignin has attracted great attention for its potential as a suitable alternative substrate compared to lignocellulosic biomass. Results A Chlorella sp. GD mutant with enhanced thermo-tolerance was obtained by mutagenesis using N-methyl-N′-nitro-N-nitrosoguanidine to overcome outdoor high-temperature inhibition and it was used as a feedstock for fermentative lactic acid production. The indoor experiments showed that biomass, reducing sugar content, photosynthetic O2 evolution rate, photosystem II activity (F v/F m and F v′/F m′), and chlorophyll content increased as temperature, light intensity, and CO2 concentration increased. The mutant showed similar DIC affinity and initial slope of photosynthetic light response curve (α) as that of the wild type but had higher dissolved inorganic carbon (DIC) utilization capacity and maximum photosynthesis rate (P max). Moreover, the PSII activity (F v′/F m′) in the mutant remained normal without acclimation process after being transferred to photobioreactor. This suggests that efficient utilization of incident high light and enhanced carbon fixation with its subsequent flux to carbohydrates accumulation in the mutant contributes to higher sugar and biomass productivity under enriched CO2 condition. The mutant was cultured outdoors in a photobioreactor with 6% CO2 aeration in hot summer season in southern Taiwan. The harvested biomass was subjected to separate hydrolysis and fermentation (SHF) for lactic acid production with carbohydrate concentration equivalent to 20 g/L glucose using the lactic acid-producing bacterium Lactobacillus plantarum 23. The conversion rate and yield of lactic acid were 80% and 0.43 g/g Chlorella biomass, respectively. Conclusions These results demonstrated that the thermo-tolerant Chlorella mutant with high photosynthetic efficiency and biomass productivity under hot outdoor condition is an efficient fermentative feedstock for large-scale lactic acid production.
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- 2017
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18. Metformin Prolongs Survival in Type 2 Diabetes Lung Cancer Patients With EGFR-TKIs
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Ming-Szu Hung MD, PhD, Min-Chun Chuang MD, Yi-Chuan Chen MD, Chuan-Pin Lee PhD, Tsung-Ming Yang MD, Pau-Chung Chen MD, PhD, Ying-Huang Tsai MD, and Yao-Hsu Yang MD, PhD
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Metformin use reportedly reduces cancer risk and improves survival in lung cancer patients. This study aimed to investigate the effect of metformin use in patients with diabetes mellitus (DM) and lung cancer receiving epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy. Methods: A nationwide, population-based cohort study was conducted using the Taiwan National Health Insurance Research Database. From January 1, 2004, to December 31, 2012, a total of 373 metformin and 1260 non-metformin lung cancer cohorts with type 2 DM and EGFR-TKI treatment were studied. Results: Metformin use was significantly associated with a reduced risk of death (hazard ratio: 0.73, 95% confidence interval [CI]: 0.62-0.85, P < .001), as well as a significantly longer median progression-free survival (9.2 months, 95% CI: 8.6-11.7, vs 6.4 months, 95% CI: 5.9-7.2 months, P < .001) and median overall survival (33.4 months, 95% CI: 29.4-40.2, vs 25.4 months, 95% CI: 23.7-27.2 months, P < 0.001). Conclusions: In conclusion, metformin may potentially enhance the therapeutic effect and increase survival in type 2 DM patients with lung cancer receiving EGFR-TKI therapy.
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- 2019
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19. Gender Differences and Work-Family Conflicts among Emergency Physicians with Intention to Leave
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Yi-Fang Wu, Po-Chang Wang, and Yi-Chuan Chen
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Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Backgrounds. The objective of this study was to investigate the relationships among intention to leave, emergency physician clinical activities, work-family conflicts, and gender differences in emergency physicians (EPs). Methods. The survey instrument was a self-administered questionnaire containing basic demographic information and characteristics of clinical activities. The work-family conflicts were assessed by the Chinese version of the work-family conflict (WIF) scale. The questionnaires were mailed to board-certified EPs between January 2014 and August 2014. Student’s t-test, Chi-square test, and one-way analysis of variance (ANOVA) were used to test the difference between subgroups. Logistic regression analysis was performed to determine the factors associated with intention to leave and gender differences. Results. The study included 222 respondents for analysis after exclusions. Compared with physicians not planning to leave, those planning to leave ED practice showed higher dissatisfaction with their clinical work hours (50.0% versus 31.4%, p = 0.035) and night/day shift ratio (52.9% versus 31.0%, p = 0.013) and tended to work with night/day shift ratio exceeding 40% (67.6% versus 45.7%, p = 0.019). Female physicians were more likely to leave ED practice (females versus males, 26.5% versus 10.1%, p = 0.008). A significantly higher level of WIF scale was noted in the group with intention to leave ED practice (3.7 ± 0.6 versus 3.3 ± 0.7, p = 0.001). Conclusions. Females and EPs with higher level of WIF scale were more likely to leave emergency clinical practice. Instead of the number of clinical practice hours, the satisfaction with the clinical work hours and night shift frequency were significantly associated with the intention to leave.
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- 2018
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20. Survival prediction among patients with non-cancer-related end-stage liver disease.
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Yi-Wen Tsai, I-Shiang Tzeng, Yi-Chuan Chen, Tsung-Han Hsieh, and Shy-Shin Chang
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Medicine ,Science - Abstract
BACKGROUND:Predicting the survival of non-cancer related end-stage-liver-disease patients in general practice has been difficult for physicians because of the extremely variable trajectories due to multiple complex clinical factors, hence it remains a challenging issue to date. This study aimed to develop and validate a specific prognostic scoring system to early recognize the prognosis and improve the quality of end-of life care for non-cancer end-stage-liver-disease population. MATERIALS AND METHODS:A multicentre, retrospective cohort study was conducted during January 2010 ~ December 2012 and continued follow-up until December 2014. A cox proportional hazard regression analysis was used to derive and validate an optimized model. The main outcome measures were the 28-day, 3-month, 6-month, and 12-month mortality prediction. The performance of the novel model was evaluated, including discrimination and calibration. RESULTS:A total of 4,080 consecutive subjects were enrolled. The AUROCs for the 3-month survival discrimination in the MELD, MELD-Na and novel model were 0.787, 0.705 and 0.804 (P
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- 2018
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21. Reinfusion of ascites during hemodialysis as a treatment of massive refractory ascites and acute renal failure
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Ta-Wei Hsu, Yi-Chuan Chen, Meei-Ju Wu, and et al
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Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Ta-Wei Hsu1, Yi-Chuan Chen2, Meei-Ju Wu2, Anna Fen-Yau Li3, Wu-Chang Yang2, Yee-Yung Ng21Department of Medicine, I-Lan Hospital, 2Division of Nephrology, Department of Medicine, 3Department of Pathology, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, TaiwanAbstract: Refractory ascites can occur in patients with various conditions. Although several procedures based on the reinfusion of ascitic fluid have been reported after the failure of bed rest, salt and water restriction, diuretics, intravenous administration of albumin, and repeated paracentesis, these procedures are performed for ascitic fluid removal without dialytic effect. In this study, a flow control reinfusion of ascites during hemodialysis (HD) was performed to demonstrate the efficacy of this method in a lupus patient with massive refractory ascites and respiratory and acute renal failure (ARF). The alleviation of ascites and ARF attests to the success of the flow control reinfusion of ascites during HD. This procedure can control the rate of ascites and body fluid removal simultaneously during HD using the roller pump. In conclusion, with a normal coagulation profile, the procedure of flow control reinfusion of ascites during HD is an effective alternative treatment for the alleviation of refractory ascites with renal failure.Keywords: ascites, lupus, renal failure, reinfusion
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- 2011
22. Determination of olanzapine and N-desmethyl-olanzapine in plasma using a reversed-phase HPLC coupled with coulochemical detection: correlation of olanzapine or N-desmethyl-olanzapine concentration with metabolic parameters.
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Mong-Liang Lu, Chia-Hui Lin, Yi-Chuan Chen, Huai-Chih Yang, and Tzu-Hua Wu
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Medicine ,Science - Abstract
Olanzapine (OLZ) is one of the most prescribed atypical antipsychotic drugs but its use is associated with unfavorable metabolic abnormalities. N-desmethyl-olanzapine (DMO), one of the OLZ metabolites by CYP1A2, has been reported to have a normalizing action on metabolic abnormalities, but this remains unclear. Our aim was to explore the correlation between the concentrations of OLZ or DMO with various metabolic parameters in schizophrenic patients.The chromatographic analysis was carried out with a solvent delivery system coupled to a Coulochem III coulometric detector to determine OLZ and DMO simultaneously in OLZ-treated patients. The correlation between the concentration of OLZ or DMO and the metabolic parameters was analyzed by the Spearman rank order correlation method (r s).The established analytical method met proper standards for accuracy and reliability and the lower limitation of quantification for each injection of DMO or OLZ was 0.02 ng. The method was successfully used for the analysis of samples from nonsmoking patients (n = 48) treated with OLZ in the dosage range of 5-20 mg per day. There was no correlation between OLZ concentrations and tested metabolic parameters. DMO concentrations were negatively correlated with glucose (r s = -0.45) and DMO concentrations normalized by doses were also negatively correlated with insulin levels (r s = -0.39); however, there was a marginally positive correlation between DMO and homocysteine levels (r s = +0.38).The observed negative correlations between levels of DMO and glucose or insulin suggest a metabolic normalization role for DMO regardless of its positive correlation with a known cardiovascular risk factor, homocysteine. Additional studies of the mechanisms underlying DMO's metabolic effects are warranted.
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- 2013
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23. Interplay of Multisensory Processing, Attention, and Consciousness as Revealed by Bistable Figures
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Su-Ling Yeh, Jhih-Yun Hsiao, Yi-Chuan Chen, and Charles Spence
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Psychology ,BF1-990 - Abstract
We examined the novel crossmodal semantic congruency effect on bistable figures in which a static stimulus gives rise to two competing percepts that alternate over time. Participants viewed the bistable figure “my wife or my mother-in-law” while listening to the voice of an old woman or a young lady speaking in an unfamiliar language. They had to report whether they saw the old woman, the young lady, or a mixed percept. Robust crossmodal semantic congruency effects in the measures of the first percept and the predominance duration were observed. The possibilities that the participants simply responded to, and/or that they fixed at the location in favor of, the percept congruent with the sound that they happened to hear were ruled out. When the participants were instructed to maintain their attention to a specific view, a strong top-down modulation on the perception of bistable figure was observed, although the audiovisual semantic congruency effect still remained. These results thus demonstrate that top-down attention (ie,, selection and/or voluntary control) modulates the audiovisual semantic congruency effect. As the alternating percepts in bistable figures indicate competition for conscious perception, this study has important implications for the multifaceted interactions between multisensory processing, attention, and consciousness.
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- 2011
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24. Crossmodal Semantic Constraints on Visual Perception of Binocular Rivalry
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Yi-Chuan Chen, Su-Ling Yeh, and Charles Spence
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Psychology ,BF1-990 - Abstract
Environments typically convey contextual information via several different sensory modalities. Here, we report a study designed to investigate the crossmodal semantic modulation of visual perception using the binocular rivalry paradigm. The participants viewed a dichoptic figure consisting of a bird and a car presented to each eye, while also listening to either a bird singing or car engine revving. Participants' dominant percepts were modulated by the presentation of a soundtrack associated with either bird or car, as compared to the presentation of a soundtrack irrelevant to both visual figures (tableware clattering together in a restaurant). No such crossmodal semantic effect was observed when the participants maintained an abstract semantic cue in memory. We then further demonstrate that crossmodal semantic modulation can be dissociated from the effects of high-level attentional control over the dichoptic figures and of low-level luminance contrast of the figures. In sum, we demonstrate a novel crossmodal effect in terms of crossmodal semantic congruency on binocular rivalry. This effect can be considered a perceptual grouping or contextual constraint on human visual awareness through mid-level crossmodal excitatory connections embedded in the multisensory semantic network.
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- 2011
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25. Synchronous Sounds Enhance Visual Sensitivity without Reducing Target Uncertainty
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Yi-Chuan Chen, Pi-Chun Huang, Su-Ling Yeh, and Charles Spence
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Psychology ,BF1-990 - Abstract
We examined the crossmodal effect of the presentation of a simultaneous sound on visual detection and discrimination sensitivity using the equivalent noise paradigm (Dosher & Lu, 1998). In each trial, a tilted Gabor patch was presented in either the first or second of two intervals consisting of dynamic 2D white noise with one of seven possible contrast levels. The results revealed that the sensitivity of participants' visual detection and discrimination performance were both enhanced by the presentation of a simultaneous sound, though only close to the noise level at which participants' target contrast thresholds started to increase with the increasing noise contrast. A further analysis of the psychometric function at this noise level revealed that the increase in sensitivity could not be explained by the reduction of participants' uncertainty regarding the onset time of the visual target. We suggest that this crossmodal facilitatory effect may be accounted for by perceptual enhancement elicited by a simultaneously-presented sound, and that the crossmodal facilitation was easier to observe when the visual system encountered a level of noise that happened to be close to the level of internal noise embedded within the system.
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- 2011
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26. The Effect of Face-to-Face Interaction on Older Adults' Attitudes Toward Robots in Human-Computer Interaction.
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Chien-Chun Yang, Su-Ling Yeh, Sung-En Chien, Tsung-Ren Huang, Yu-Ling Chang, Joshua Oon Soo Goh, Yi-Chuan Chen, and Li-Chen Fu
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- 2023
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27. Differences in Color Representations of Tastes: Cross-cultural Study Among Japanese, Russian and Taiwanese.
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Alexander Raevskiy, Ivan Bubnov, Yi-Chuan Chen, and Nobuyuki Sakai
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- 2022
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28. Sex Differences in the Association between Vitamin D and Early-Stage Chronic Kidney Disease: a Population-Based Study
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Ting-An Yang, Jau-Yuan Chen, Chieh-An Lin, Yi-Chuan Chen, Wei Yu, Hsiung Ying Huang, Xue-Jie Xiong, and Wen-Cheng Li
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Nutrition and Dietetics ,Endocrinology ,Endocrinology, Diabetes and Metabolism - Published
- 2023
29. Performance Evaluation of AFeRAM under Low Temperature Operation
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Yi-Chuan Chen, Yu-Chen Chen, Kuo-Yu Hsiang, Min-Hung Lee, and Pin Su
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- 2023
30. Snacking among shiftwork nurses related to <scp>non‐optimal</scp> dietary intake
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Ting‐Ti Lin, Yue Leon Guo, Christopher James Gordon, Yi‐Chuan Chen, Hsueh‐Ching Wu, Elizabeth Cayanan, Chung‐Mei Ouyang, and Judith Shu‐Chu Shiao
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Eating ,Humans ,Feeding Behavior ,Longitudinal Studies ,Snacks ,Energy Intake ,Meals ,General Nursing - Abstract
To compare nurses' non-optimal eating behaviours across different shifts, to examine whether non-day shifts were related to deviation from optimal dietary behaviours compared with day shifts and whether such deviation was related to non-optimal macronutrient intake.This is a 4-day intensive longitudinal study.A convenience sample of hospital nurses was recruited in Taiwan. From September 2018 through January 2019, 120 participants completed 4-days of 24-h dietary recalls. One-way ANOVA and Kruskal-Wallis H test were used to compare differences in energy and macronutrient intake and frequency of meals and snacking, respectively. Generalized linear regressions examined (1) the associations between shiftwork schedules and non-optimal eating behaviours and (2) associations between non-optimal eating and high energy contribution of non-optimal macronutrients.Nurses consumed less energy on evening and night shifts compared with day shifts. However, energy intake from snacking was higher on evening and night shifts relative to day shifts. Nurses consumed less meals but had higher snacking frequency on non-day shifts. In addition, high energy intake from snacking was positively associated with high energy intake from saturated fat.Nurses were more likely to have non-optimal eating behaviours on non-day shifts, which may contribute to an increased intake of saturated fat; thus, increasing their risk of chronic diseases. Strategies to improve non-day shift nurses' non-optimal eating behaviours may be beneficial to their health.Shiftwork is known to affect nurses' eating behaviours; however, which shift is associated with unhealthy eating remains inconclusive. Despite lower energy intakes, nurses had higher intake by snacking on evening and night shifts. High snacking intake was associated with a high intake of saturated fat. Hospitals can increase the availability of healthy foods on evening or night shifts, which may improve non-day shift nurses' non-optimal eating behaviours.
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- 2022
31. Long-Term Exposure to Air Pollution and the Occurrence of Metabolic Syndrome and Its Components in Taiwan
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Yi-Chuan Chen, Wei-Shan Chin, Shih-Chun Pan, Chih-Da Wu, and Yue-Liang Leon Guo
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Adult ,Metabolic Syndrome ,Blood Glucose ,Air Pollutants ,Health, Toxicology and Mutagenesis ,Nitrogen Dioxide ,Public Health, Environmental and Occupational Health ,Taiwan ,Environmental Exposure ,Obesity, Abdominal ,Air Pollution ,Hypertension ,Humans ,Particulate Matter ,Obesity - Abstract
Metabolic syndrome (MetS), a major contributor to cardiovascular and metabolic diseases, has been linked with exposure to air pollution. However, the relationship between air pollutants and the five components of MetS [abdominal obesity, elevated triglyceride, decreased high-density lipoprotein cholesterol (HDL-C), elevated blood pressure, and elevated fasting blood glucose levels], has not been clearly described.We examined the association between long-term exposure to air pollutants and the occurrence of MetS and its components by using a longitudinal cohort in Taiwan.The MJ Health Research Foundation is a medical institute that conducts regular physical examinations. The development of MetS, based on a health examination and the medical history of an MJ cohort of 93,771 participants who were enrolled between 2006 and 2016 and had two or more examinations, was compared with estimated exposure to air pollutants in the year prior to health examination. The exposure levels to fine particulate matter [PM with an aerodynamic diameter ofDuring the average follow-up period of 3.4 y, the incidence of MetS was 38.1/1,000 person-years. After mutual adjustment and adjustments for potential covariates, the results indicated that everyOur findings suggest that in apparently healthy adults undergoing physical examination, exposure to
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- 2023
32. The Effects of Mandarin Chinese Lexical Tones in Sound–Shape and Sound–Size Correspondences
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Yen-Han Chang, Mingxue Zhao, Yi-Chuan Chen, and Pi-Chun Huang
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China ,Ophthalmology ,Sound ,Cognitive Neuroscience ,Speech Perception ,Humans ,Experimental and Cognitive Psychology ,Computer Vision and Pattern Recognition ,Sensory Systems - Abstract
Crossmodal correspondences refer to when specific domains of features in different sensory modalities are mapped. We investigated how vowels and lexical tones drive sound–shape (rounded or angular) and sound–size (large or small) mappings among native Mandarin Chinese speakers. We used three vowels (/i/, /u/, and /a/), and each vowel was articulated in four lexical tones. In the sound–shape matching, the tendency to match the rounded shape was decreased in the following order: /u/, /i/, and /a/. Tone 2 was more likely to be matched to the rounded pattern, whereas Tone 4 was more likely to be matched to the angular pattern. In the sound–size matching, /a/ was matched to the larger object more than /u/ and /i/, and Tone 2 and Tone 4 correspond to the large–small contrast. The results demonstrated that both vowels and tones play prominent roles in crossmodal correspondences, and sound–shape and sound–size mappings are heterogeneous phenomena.
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- 2021
33. The limits of unconscious semantic priming
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Sung-En Chien, Wei-Chen Chang, Yi-Chuan Chen, Shu-Lih Huang, and Su-Ling Yeh
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General Psychology - Published
- 2022
34. [Safety Climate in Hospitals: From Science to Policy-The Progress of Needlestick Prevention in Taiwan]
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Hsueh-Ching, Wu, Yu-Shan, Ou, Wei-Shan, Chin, Li-Jie, Wang, Yi-Chuan, Chen, Ting-Ti, Lin, and Shu-Chu Judith, Shiao
- Subjects
Occupational Stress ,Policy ,Taiwan ,Humans ,Needlestick Injuries ,Organizational Culture ,Hospitals - Abstract
In hospitals, safety climate refers to the safety policies and regulations established by medical institutions and the measures taken to ensure medical personnel feel safe while working at these institutions. Safety climate can directly affect the overall work performance of medical personnel and indirectly affect patient care quality, which in turn impacts the rate of occupational hazards. Common occupational hazards in the medical workplace include contracting infectious diseases, overwork, irregular circadian rhythm due to working shifts, changes in sleep patterns and dietary habits, musculoskeletal discomfort, workplace violence, workplace stress, and needlestick injuries. This paper was developed to explore the history of promoting needlestick prevention in Taiwan, and discusses how to use the results of empirical research as scientific evidence and critical proofs to advocate for needlestick prevention and to establish related policies. In addition, the process of how improvements to the hospital safety climate and the prevention of occupational hazard incidents mutually influence and complement each other was examined. Future studies are encouraged to explore this topic to further elucidate the sources of workplace stress and to devise methods to ameliorate their influence on workplace stress in medical institutions. The results of these studies may be referenced by relevant government agencies and medical institutions when developing policies promoting safe environments in hospitals that improve the safe-work perceptions of nursing personnel and create comfortable and friendly medical environments.醫院安全風氣:由科學到政策—臺灣針扎防治歷程.醫療機構所建立相關的安全政策與制度,讓醫療人員感受到組織安全的相關作為,即是醫院安全風氣,其可以直接影響醫療人員整體工作表現,及間接地影響病人的照護品質,並進一步影響職業危害的發生狀況。醫療職場常見的職業危害,包含傳染性疾病、過勞高風險、輪班造成的晝夜節律、睡眠型態與飲食習慣改變、肌肉骨骼不適、職場暴力、職場壓力及針扎等;本文即是分享臺灣在針扎防治的推動歷程,如何運用實證研究結果的科學證據,倡議及提供政策制定的重要佐證及說帖,進而提升醫院安全風氣與職業危害事件降低之互相影響與改善的過程;未來應鼓勵透過更多的科學研究投入,針對職場壓力源的了解與改善,提供政府主管部門及醫療機構制定政策之參考,以創造安全風氣高的護理執業環境及提升護理人員對執業環境安全的整體知覺,共創合宜、友善的醫療執業環境。.
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- 2022
35. Developmental changes in audiotactile event perception
- Author
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Brendan M. Stanley, Yi-Chuan Chen, Daphne Maurer, Terri L. Lewis, and David I. Shore
- Subjects
Developmental and Educational Psychology ,Experimental and Cognitive Psychology - Published
- 2023
36. Stimulus temporal uncertainty balances intersensory dominance
- Author
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Pi-Chun Huang and Yi-Chuan Chen
- Subjects
Adult ,Experimental and Cognitive Psychology ,Sensory system ,050105 experimental psychology ,Stimulus (psychology) ,03 medical and health sciences ,Tone (musical instrument) ,Flash (photography) ,0302 clinical medicine ,Arts and Humanities (miscellaneous) ,Reaction Time ,Developmental and Educational Psychology ,Humans ,0501 psychology and cognitive sciences ,Predictability ,Jitter ,05 social sciences ,Uncertainty ,Degree (music) ,Dominance (ethology) ,Acoustic Stimulation ,Auditory Perception ,Visual Perception ,Psychology ,Photic Stimulation ,030217 neurology & neurosurgery ,Cognitive psychology - Abstract
Vision is typically dominant over audition or touch in human adults. One classic example is the Colavita visual dominance effect: The presentation of a tone sometimes goes undetected when it is paired with a flash even though it is well detected when presented alone. We investigated whether the Colavita visual dominance effect is modulated by stimulus uncertainty in the temporal and spatial domains. In a simple discrimination task, participants were asked to press a predesignated key when detecting a flash, another key when detecting a tone, and both keys when detecting both a flash and a tone. Temporal uncertainty was increased by introducing temporal jitter between trials (Experiment 1), and spatial uncertainty was increased by shifting the flash to different locations (Experiment 2). The Colavita visual dominance effect was reduced when temporal uncertainty was increased, while it remained similar when spatial uncertainty was increased. We therefore demonstrate a novel consideration, where increasing temporal uncertainty balances the competition between vision and audition, suggesting that people's degree of sensory dominance is malleable. Our result therefore highlights the concept that intersensory competition is susceptible to the temporal predictability of the stimulus, which provides critical insights into the design of effective warning systems in the field of ergonomics.
- Published
- 2021
37. Sodium bicarbonate administration during in-hospital pediatric cardiac arrest: A systematic review and meta-analysis
- Author
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Chih-Yao Chang, Po-Han Wu, Chia-Peng Chang, Kai-Hsiang Wu, Yi-Chuan Chen, and Cheng-Ting Hsiao
- Subjects
medicine.medical_specialty ,Resuscitation ,Subgroup analysis ,030204 cardiovascular system & hematology ,Emergency Nursing ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Child ,business.industry ,030208 emergency & critical care medicine ,Odds ratio ,Guideline ,Cardiopulmonary Resuscitation ,Hospitals ,Patient Discharge ,Confidence interval ,Sodium Bicarbonate ,Meta-analysis ,Life support ,Emergency Medicine ,Observational study ,Cardiology and Cardiovascular Medicine ,business ,Out-of-Hospital Cardiac Arrest - Abstract
Background Current American Heart Association Pediatric Life Support (PLS) guidelines do not recommend the routine use of sodium bicarbonate (SB) during cardiac arrest in pediatric patients. However, SB administration during pediatric resuscitation is still common in clinical practice. The objective of this study was to assess the impact of SB on mortality and neurological outcomes in pediatric patients with in-hospital cardiac arrest. Methods We searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials from inception to January 2021. We included studies of pediatric patients that had two treatment arms (treated with SB or not treated with SB) during in-hospital cardiac arrest (IHCA). Risk of bias was assessed using the Newcastle-Ottawa Scale and the certainty of evidence was assessed using GRADE system. Results We included 7 observational studies with a total of 4877 pediatric in-hospital cardiac arrest patients. Meta-analysis showed that SB administration during pediatric cardiac resuscitation was associated with a significantly decreased rate of survival to hospital discharge (odds ratio [OR], 0.40; 95% confidence interval [CI], 0.25–0.63, p value = 0.0003). There were insufficient studies for 24-h survival and neurologic outcomes analysis. The subgroup analysis showed a significantly decreased rate of survival to hospital discharge in both the “before 2010” subgroup (OR 0.47; 95% CI 0.30–0.73; p value = 0.006) and the “after 2010” subgroup (OR 0.46; 95% CI 0.25–0.87; p value = 0.02). The certainty of evidence ranged from very low to low. Conclusions This meta-analysis of non-randomized studies supported current PLS guideline that routine administration of SB is not recommended in pediatric cardiac arrest except in special resuscitation situations. Trial registration The protocol was registered with PROSPERO on 8 August 2020 (registration number: CRD42020197837).
- Published
- 2021
38. Effectiveness of Sodium Bicarbonate Administration on Mortality in Cardiac Arrest Patients: A Systematic Review and Meta-analysis
- Author
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Chih-Yao Chang, Yi-Chuan Chen, Cheng-Ting Hsiao, Chia-Peng Chang, Hsu-Huei Weng, and Kai-Hsiang Wu
- Subjects
Adult ,Resuscitation ,business.industry ,Mortality rate ,Advanced cardiac life support ,030208 emergency & critical care medicine ,Subgroup analysis ,Odds ratio ,030204 cardiovascular system & hematology ,Return of spontaneous circulation ,Advanced Cardiac Life Support ,Cardiopulmonary Resuscitation ,Patient Discharge ,Confidence interval ,Heart Arrest ,03 medical and health sciences ,Sodium Bicarbonate ,0302 clinical medicine ,Anesthesia ,Meta-analysis ,Emergency Medicine ,Humans ,Medicine ,business ,Out-of-Hospital Cardiac Arrest - Abstract
Background The 2010 Advanced Cardiac Life Support guidelines stated that routine sodium bicarbonate (SB) use for cardiac arrest patients was not recommended. However, SB administration during resuscitation is still common. Objectives To evaluate the effect of SB on return of spontaneous circulation (ROSC) and survival-to-discharge rates in adult cardiac arrest patients. Methods We searched Medline, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to December 2019. We included trials on nontraumatic adult patients after cardiac resuscitation and SB treatment vs. controls. Results A meta-analysis was performed with six observational studies, including 18,406 adult cardiac arrest patients. There were no significant differences in the ROSC rate (odds ratio [OR] 1.185; 95% confidence interval [CI] 0.680–2.065) and survival-to-discharge rate (OR 0.296; 95% CI 0.066–1.323) between the SB and no-SB groups. In the subgroup analysis based on the year factor, there were no significant differences in the mortality rate in the After-2010 group. In the subgroup analysis based on the continent, the ROSC rate (OR 0.521; 95% CI 0.432–0.628) and survival-to-discharge rate (OR 0.102; 95% CI 0.066–0.156) were significantly lower in the North American group. Conclusions SB use was not associated with improvement in ROSC or survival-to-discharge rates in cardiac resuscitation. In addition, mortality was significantly increased in the North American group with SB administration.
- Published
- 2020
39. Incomplete off-duty work hours and sleep quality among firefighters: a cross-sectional study, Taiwan
- Author
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Rou-Shiuan Huang, Yi-Chuan Chen, Shang-Yin Tsai, Yan-Siang Eason Huang, and Yue-Liang Leon Guo
- Subjects
Public Health, Environmental and Occupational Health - Abstract
We examined whether firefighters in Taiwan have a sleep problem and investigated the related factors of poor sleep quality.In this cross-sectional study, 2123 male shift firefighters in the Greater Taipei area were invited, and 37.7% of them satisfactorily completed the questionnaire online. The Chinese version of Pittsburgh sleep quality index (PSQI) was used to evaluate sleep quality. Multiple logistic and linear regression analyses were used to determine the associations among demographic characteristics, work-related characteristics, and poor sleep quality.As revealed by 801 valid questionnaires, 77.2% were poor sleepers (PSQI cutoff score 6), and 61.2% reported incomplete off-duty in the past month. Moreover, 42.6% of incomplete off-duty workers reported extended overtime of more than 5 h on off-duty days in the past month. Poor sleep quality was associated with the following factors: (1) demographic characteristics: age, working tenure, having children, and chronotype and (2) work-related characteristics: shift schedule and incomplete off-duty. The final model for poor sleep quality as per PSQI included age, chronotype, shift schedule, and incomplete off-duty hours in the past month. Longer hours of incomplete off-duty work were associated with increased risks of overall poor sleep quality and of poor subjective sleep quality, long sleep latency, sleep disturbances, and daytime dysfunction.Firefighters are advised to have a complete off-duty day to avoid poor sleep quality, long sleep latency, short sleep duration, sleep disturbances, and daytime dysfunction. Our results confirm the need for implementing appropriate shift schedules to ensure adequate rest time for firefighters.
- Published
- 2022
40. Erectile Dysfunction After Surgical Treatment of Lung Cancer: Real-World Evidence
- Author
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Ming-Szu Hung, Yao-Hsu Yang, Pau-Chung Chen, Yi-Chuan Chen, Chuan-Pin Lee, Tsung-Yu Huang, and Dong-Ru Ho
- Subjects
Lung cancer surgery ,medicine.medical_specialty ,Epidemiology ,business.industry ,Incidence (epidemiology) ,Cancer ,030204 cardiovascular system & hematology ,Rate ratio ,medicine.disease ,Confidence interval ,03 medical and health sciences ,0302 clinical medicine ,Erectile dysfunction ,Internal medicine ,Cohort ,medicine ,030212 general & internal medicine ,Lung cancer ,business - Abstract
Background Sexual problems are common in male lung cancer survivors. However, the development of erectile dysfunction (ED) in lung cancer patients after surgery has been rarely explored. In this study, we aimed to explore the incidence and risk factors of ED after lung cancer surgery. Methods From 2000 to 2012, 6025 and 24,100 male patients were included in each matched cohort of lung cancer and non-lung cancer patients, respectively. Poisson regression analysis was used to calculate the incidence rate ratio (IRR) and 95% confidence interval (CI). Results The incidence of ED was higher in the lung cancer cohort compared to the non-lung cancer cohort (38.47 vs 28.28 per 10,000 person-years) with an adjusted IRR (aIRR) of 1.34 (95% CI: 1.06-1.70, p=0.014) after the confounders were adjusted for. An increased incidence of ED was observed in the lung cancer cohort aged 40-54 years (aIRR: 5.44, 95% CI: 2.25-13.15, p
- Published
- 2020
41. Age-Related Changes in Audiovisual Simultaneity Perception and Their Relationship With Working Memory
- Author
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Pei-Fang Tang, Yi-Chuan Chen, and Su-Ling Yeh
- Subjects
Adult ,Male ,Aging ,Social Psychology ,media_common.quotation_subject ,Auditory signal ,Model fitting ,Stimulus (physiology) ,Spatial memory ,050105 experimental psychology ,Judgment ,03 medical and health sciences ,0302 clinical medicine ,Perception ,Age related ,Humans ,0501 psychology and cognitive sciences ,Aged ,media_common ,Working memory ,Cambridge Neuropsychological Test Automated Battery ,05 social sciences ,Recognition, Psychology ,Clinical Psychology ,Memory, Short-Term ,Acoustic Stimulation ,Case-Control Studies ,Auditory Perception ,Visual Perception ,Female ,Geriatrics and Gerontology ,Psychology ,Gerontology ,Photic Stimulation ,030217 neurology & neurosurgery ,Cognitive psychology - Abstract
Objectives Perceiving simultaneity of a visual and an auditory signal is critical for humans to integrate these multisensory inputs effectively and respond properly. We examined age-related changes in audiovisual simultaneity perception, and the relationships between this perception and working memory performances with aging. Methods Audiovisual simultaneity perception of young, middle-aged, and older adults was measured using a simultaneity judgment (SJ) task, in which a flash and a beep were presented at 1 of 11 stimulus-onset asynchronies (SOAs). Participants judged whether these two stimuli were perceived simultaneously. Precision of simultaneity perception, the SOA corresponding to the point of subjective simultaneity (PSS), and response errors at each SOA were estimated using model fitting. The precision and PSS are associated with multisensory perception per se, whereas the response error reflects executive ability when performing the SJ task. Visual working memory of the same middle-aged and older adults was measured using the Cambridge Neuropsychological Test Automated Battery (CANTAB) beforehand. Results Compared to young adults’ performances, middle-aged and older adults showed a decreased precision, a shift of PSS toward the visual-leading SOAs, and increased response errors at the visual-leading SOAs. Among these changes, only the increased response errors correlated with worse spatial recognition memory in middle-aged and older adults. Discussion Age-related decrements in audiovisual simultaneity perception start from middle age and are manifested in both perceptual and executive parameters. Furthermore, higher-order executive ability is plausibly a common cause for age-related degenerations in the audiovisual simultaneity perception and visual working memory.
- Published
- 2020
42. Dipeptidyl peptidase-4 inhibitors and the risks of autoimmune diseases in type 2 diabetes mellitus patients in Taiwan: a nationwide population-based cohort study
- Author
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Jau Yuan Chen, Ling Yeung, Tien Hsing Chen, Chi Chin Sun, Yi Chuan Chen, Shy Shin Chang, and Yi Wen Tsai
- Subjects
Adult ,Male ,medicine.medical_specialty ,Databases, Factual ,Endocrinology, Diabetes and Metabolism ,Taiwan ,030209 endocrinology & metabolism ,Subgroup analysis ,030204 cardiovascular system & hematology ,Lower risk ,Autoimmune Diseases ,Cohort Studies ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Hypoglycemic Agents ,Aged ,Retrospective Studies ,Aged, 80 and over ,Autoimmune disease ,Dipeptidyl-Peptidase IV Inhibitors ,business.industry ,Incidence ,Incidence (epidemiology) ,Type 2 Diabetes Mellitus ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Diabetes Mellitus, Type 2 ,Rheumatoid arthritis ,Female ,business - Abstract
Dipeptidyl peptidase-4, a transmembrane glycoprotein expressed in various cell types, serves as a co-stimulator molecule to influence immune response. This study aimed to investigate associations between DPP-4 inhibitors and risk of autoimmune disorders in patients with type 2 diabetes mellitus in Taiwan. This retrospective cohort study used the nationwide data from the diabetes subsection of Taiwan National Health Insurance Research Database between January 1, 2009, and December 31, 2013. Cox proportional hazards models were developed to compare the risk of autoimmune disorders and the subgroup analyses between the DPP-4i and DPP-4i-naive groups. A total of 774,198 type 2 diabetic patients were identified. The adjusted HR of the incidence for composite autoimmune disorders in DPP-4i group was 0.56 (95% CI 0.53–0.60; P
- Published
- 2020
43. Hospital factors that predict intention of health care workers to leave their job during the COVID-19 pandemic
- Author
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Yi‐Chuan Chen, Hsueh‐Ching Wu, Feng‐Tze Kuo, David Koh, Yue‐Liang Leon Guo, and Judith Shu‐Chu Shiao
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Adult ,Health Personnel ,COVID-19 ,Personnel Turnover ,Intention ,Hospitals ,Job Satisfaction ,Coronavirus ,Occupational Stress ,Cross-Sectional Studies ,Surveys and Questionnaires ,Humans ,Pandemics ,General Nursing - Abstract
PURPOSE: To identify factors responsible for hospital health care workers' intention to leave their job during the COVID-19 pandemic. DESIGN: A cross-sectional study was performed. METHODS: A self-administered questionnaire was delivered to solicit hospital health care workers' demographics, intention to leave, workplace environment, and changes related to COVID-19 from July to November 2020 in Taiwan. Principal component analysis was performed to compare group-related factors. Multiple logistic regression was used to determine the risk factors for the intention of health care workers to leave their job. FINDINGS: Among the 1209 health care workers (mean age, 36.3 years) who participated in the study, intention to leave the job was found to be related to factors relating to COVID-19, including perceived risk, affected social relationships, and increased workload and job stress, after adjustment for demographic and work factors. Supportive administration/management were protective factors against leaving the job. These results were supported by sensitivity analyses. CONCLUSIONS: Our findings suggest that the intention of health care workers to leave their job during a pandemic is related to potentially modifiable factors relating to the infection itself and work environment. CLINICAL RELEVANCE: High perceived risk of COVID-19, affected social relationaops, and increased workload and job stress were positively associated with the intention of health care workers to leave their job, whereas supportive administration and management were protective factors against leaving the job. Development of workplace strategies is important to help mitigate these above factors, improve psychological wellbeing, and promote workforce stability.
- Published
- 2022
44. Correction to: Differences in Color Representations of Tastes: Cross-cultural Study Among Japanese, Russian and Taiwanese
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Alexander Raevskiy, Ivan Bubnov, Yi-Chuan Chen, and Nobuyuki Sakai
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- 2022
45. Seeing Sounds: The Role of Vowels and Consonants in Crossmodal Correspondences
- Author
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Yang-Chen Shen, Yi-Chuan Chen, and Pi-Chun Huang
- Subjects
Ophthalmology ,Artificial Intelligence ,Experimental and Cognitive Psychology ,Sensory Systems - Abstract
Crossmodal correspondences refer to the fact that certain domains of features in different sensory modalities are associated with each other. Here, we investigated the crossmodal correspondences between speech sounds and visual shapes. Specifically, we tested whether the classification dimensions of English vowels (front–central–back) and consonants (voiced–voiceless, sonorant–obstruent, and stop–continuant) correspond to visual shapes along a bipolar rounded–angular dimension. We adapted eighteen meaningless pseudowords from a previous study that corresponded to either the round or the sharp concept. On each trial, the participants heard one of the pseudowords and saw a rounded shape and an angular shape presented side-by-side on the monitor. Participants judged which shape provided a better match to the spoken pseudoword. A logistic regression was conducted in order to elucidate the effectiveness of classification dimensions of phonemes when predicting variations in the sound–shape matchings. The results demonstrated that the sound–shape matchings were predictable using front–central–back dimensions of vowels, and voiced–voiceless and stop–continuant dimensions of consonants. Hence, we verified that sound–shape matching is underpinned by contrasting dimensions in both vowels and consonants, therefore demonstrating crossmodal correspondences at the phonetic level.
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- 2021
46. Short sleep and chronic neck and shoulder discomfort in nurses
- Author
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Wei-Shan Chin, Judith Shu-Chu Shiao, Yueliang Leon Guo, Ting-Ti Lin, and Yi-Chuan Chen
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Adult ,medicine.medical_specialty ,Time Factors ,Referral ,musculoskeletal discomfort ,Prevalence ,Psychological intervention ,Taiwan ,Nursing Staff, Hospital ,Logistic regression ,nurses ,03 medical and health sciences ,0302 clinical medicine ,Shoulder Pain ,Medicine ,Humans ,030212 general & internal medicine ,Sleep restriction ,Sleep hygiene ,Neck Pain ,Shoulder discomfort ,business.industry ,Public Health, Environmental and Occupational Health ,Original Articles ,Middle Aged ,030210 environmental & occupational health ,neck discomfort ,Occupational Diseases ,Cross-Sectional Studies ,short sleep duration ,Attributable risk ,Physical therapy ,shoulder discomfort ,Original Article ,Female ,Chronic Pain ,business ,Sleep - Abstract
Objective Short sleep duration is common among nurses. Sleep restriction has been associated with musculoskeletal discomfort. However, studies on the effect of short sleep duration on chronic neck and shoulder discomfort in nurses have been lacking. The aim of this study was to determine whether short sleep duration is related to chronic neck and shoulder discomfort. Methods We conducted a cross‐sectional survey of female nurses in secondary referral health centers in Taiwan. We applied stratified sampling based on region (north, central, south, and east) to select representative centers for this study. A self‐administered structured questionnaire, including demographic data, the psychological working environment, and musculoskeletal symptoms, was administered to nurses. Multiple logistic regression and population attributable risk analyses were performed to assess the effect of average sleeping hours per working day on chronic neck and shoulder discomfort. Results A total of 1602 (78.9%) questionnaires were eligible for final analysis. The prevalence rates of chronic neck and shoulder discomfort were 33.9% and 34.7%, respectively. Population attributable risk estimation revealed that a sleep duration of
- Published
- 2021
47. The Relationship Between Fluid Accumulation in Ultrasonography and the Diagnosis and Prognosis of Patients with Necrotizing Fasciitis
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Kuang-Yu Hsiao, Chia-Peng Chang, Cheng-Ting Hsiao, Yi-Chuan Chen, Tsung-Yu Huang, Wen-Chih Fann, and Chun-Nan Lin
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medicine.medical_specialty ,Acoustics and Ultrasonics ,Radiological and Ultrasound Technology ,business.industry ,medicine.medical_treatment ,Mortality rate ,Biophysics ,Retrospective cohort study ,medicine.disease ,Amputation ,medicine ,Radiology, Nuclear Medicine and imaging ,Deep fascia ,Radiology ,Fluid accumulation ,Cutoff point ,Ultrasonography ,business ,Fasciitis - Abstract
Necrotizing fasciitis is a severe soft-tissue infection with a high mortality rate. There is little literature on the relationship between the ultrasonographic finding of fluid accumulation along the deep fascia and the diagnosis and prognosis of necrotizing fasciitis. This retrospective study showed that when fluid accumulation was present along the deep fascia, patients with clinically suspected necrotizing fasciitis had a higher probability of having necrotizing fasciitis. The ultrasonographic finding of fluid accumulation with a cutoff point of more than 2 mm of depth had the best accuracy (72.7%) for diagnosing necrotizing fasciitis. In regard to the prognosis of necrotizing fasciitis, when fluid accumulation was present along the deep fascia, patients with necrotizing fasciitis had a longer length of hospital stay and were at risk of amputation or mortality. Ultrasonography is a point-of-care imaging tool that facilitates the diagnosis and prognosis of necrotizing fasciitis.
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- 2019
48. Proximal gastrectomy versus total gastrectomy for adenocarcinoma of the esophagogastric junction: a meta-analysis
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Kai-Hu Fan, Dao-Han Wang, Wei-Hua Fu, Yi-Chuan Chen, and Li Lu
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medicine.medical_specialty ,Ileus ,medicine.medical_treatment ,Operative Time ,Adenocarcinoma ,Anastomosis ,Cochrane Library ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Gastrectomy ,Stomach Neoplasms ,Internal medicine ,medicine ,Humans ,Retrospective Studies ,business.industry ,Health Policy ,Reflux ,Cancer ,medicine.disease ,Survival Rate ,Treatment Outcome ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Esophagogastric Junction ,Complication ,business - Abstract
Aim: To compare efficacy between total gastrectomy (TG) and proximal gastrectomy (PG) for upper-third gastric cancer. Materials & methods: PubMed, Embase and Cochrane library were searched to select suitable researches. Stata was used for meta-analysis including 5-year overall survival rate, recurrence rate, complication morbidities and serum nutritional levels. Results: Ten retrospective English researches were contained. Our study showed no significant difference of 5-year overall survival rate, recurrence rate, reflux symptoms and anastomotic leakage. TG experienced longer operation time, more lymph nodes-retrieved number, more estimated blood loss and higher ileus, but less anastomotic stricture. PG showed advantages over TG in terms of serum nutritional levels. Conclusion: PG is more preferable to TG for treatment of upper-third gastric cancer.
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- 2019
49. Massive transfusion in upper gastrointestinal bleeding: a new scoring system
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Chen-Ju Chuang, Yi-Chuan Chen, Huan-Wen Chen, Shung-Chieh Lee, Leng-Chieh Lin, Kuang-Yu Hsiao, and Ming-Szu Hung
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Male ,medicine.medical_specialty ,Scoring system ,Blood Pressure ,030204 cardiovascular system & hematology ,Risk Assessment ,Severity of Illness Index ,Hemoglobins ,03 medical and health sciences ,0302 clinical medicine ,Heart Rate ,medicine ,Humans ,Blood Transfusion ,In patient ,International Normalized Ratio ,030212 general & internal medicine ,Aged ,Retrospective Studies ,Aged, 80 and over ,Framingham Risk Score ,business.industry ,Endoscopy ,General Medicine ,medicine.disease ,Massive transfusion ,Surgery ,Research Design ,Female ,Original Article ,Upper gastrointestinal bleeding ,Gastrointestinal Hemorrhage ,business - Abstract
Background: Massive transfusion in patients with upper gastrointestinal bleeding (UGIB) was not investigated. We developed a new scoring system to predict massive transfusion and to enhance care and early resource mobilization. Methods: Massive transfusion was defined as transfusion with ≥10 units of red blood cells within the first 24 h. Data were extracted from a 10-year, six-hospital database. Logistic regression was applied to derive a risk score for massive transfusion using data from 2006 to 2010, in 24,736 patients (developmental cohort). The score was then validated using data from 2011 to 2015 in 27,449 patients (validation cohort). Area under the receiver operating characteristic (AUROC) curve was performed to assess prediction accuracy. Results: Five characteristics were independently associated (p 0), international normalized ratio (INR) >1.5, pulse >100 beats per minute or systolic blood pressure Conclusions: The new scoring system predicts massive transfusion requirement in patients with UGIB well.Key messagesMassive transfusion is a life-saving management in massive upper gastrointestinal bleeding. How to identify patients requiring massive transfusion in upper gastrointestinal bleeding is poorly documented.Approximately 3.9% of upper gastrointestinal bleeding patients require massive transfusion.A new scoring system is developed to identify patients requiring massive transfusion with high accuracy. Massive transfusion is a life-saving management in massive upper gastrointestinal bleeding. How to identify patients requiring massive transfusion in upper gastrointestinal bleeding is poorly documented. Approximately 3.9% of upper gastrointestinal bleeding patients require massive transfusion. A new scoring system is developed to identify patients requiring massive transfusion with high accuracy.
- Published
- 2019
50. The Association of Annexin A1 and Chemosensitivity to Osimertinib in Lung Cancer Cells
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Ya-Chin Li, Min-Chun Chuang, Yu-Ching Lin, Ming-Szu Hung, Jrhau Lung, and Yi-Chuan Chen
- Subjects
Cancer Research ,endocrine system ,Kinase ,business.industry ,target therapy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,respiratory system ,medicine.disease ,medicine.disease_cause ,annexin A1 ,Article ,respiratory tract diseases ,lung cancer ,Oncology ,Epidermal growth factor ,Apoptosis ,medicine ,Cancer research ,Osimertinib ,Lung cancer ,Carcinogenesis ,business ,Protein kinase B ,RC254-282 ,Annexin A1 - Abstract
Simple Summary Annexin A1 (ANXA1) is associated with the growth and resistance to chemotherapy drugs in lung cancer cells. In this study, the association of ANXA1 with chemosensitivity to Osimertinib, a third generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) was studied. The knockdown of ANXA1 increased chemosensitivity to Osimertinib and decreased tumorigenesis, invasion and migration of lung cancer cells with EGFR mutations. The study showed that ANXA1 plays critical roles in chemosensitivity to Osimertinib in lung cancer cells with EGFR mutations. Abstract Annexin A1 (ANXA1) has been reported to promote tumor growth and resistance to chemotherapy drugs in lung cancer cells. In this study, we focused on the association of ANXA1 and chemosensitivity with a third generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), Osimertinib, in lung cancer cells with EGFR mutations. The overexpression of ANXA1 was observed in the lung cancer cells studied. The downregulation of ANXA1 with small interference RNA (siRNA) decreased the growth of lung cancer cells. In lung cancer cells with EGFR mutations, the knockdown of ANXA1 increased the chemosensitivity to Osimertinib, and decreased the tumorigenesis, invasion and migration of lung cancer cells. Further study showed that the knockdown of ANXA1 inhibited the phosphorylation of EGFR and down-stream Akt pathways and promoted apoptosis in lung cancer cells treated with Osimertinib. A mice xenograft lung cancer model was established in our study and showed that ANXA1 siRNA enhanced the effects of Osimertinib in vivo. Our study results showed that ANXA1 plays critical roles in chemosensitivity to EGFR-TKI in lung cancer cells with the EGFR mutation. Our efforts may be used in the development of lung cancer treatment strategies in the future.
- Published
- 2021
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