17 results on '"Yi-Chiao Li"'
Search Results
2. Prognostic Factors and Epidemiology of Open Globe Injuries from Western Sydney: A Twelve-Year Review
- Author
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Haochi Ho, Jane Foo, Yi-Chiao Li, Samantha Bobba, Christopher Go, Jaya Chandra, and Adrian Fung
- Subjects
genetic structures ,eye diseases - Abstract
BackgroundTo identify prognostic factors determining final visual outcome following open globe injuries.MethodsRetrospective case series of patients presenting to Westmead Hospital, Sydney, Australia with open globe injuries from 1st January 2005 to 31st December 2017. Data collected included demographic information, ocular injury details, management and initial and final visual acuities.ResultsA total of 104 cases were identified. Predictors of poor final visual outcomes included poor presenting visual acuity (p < 0.001), globe rupture (p < 0.001), retinal detachment (p < 0.001), Zone III wounds (p < 0.001), hyphema (p=0.003), lens expulsion (p = 0.003) and vitreous hemorrhage (p < 0.001). Multivariate analysis demonstrated presenting visual acuity (p < 0.001), globe rupture (p = 0.013) and retinal detachment (p = 0.011) as being statistically significant for predicting poor visual outcomes. The presence of lid laceration (p = 0.197) and uveal prolapse (p = 0.667) were not significantly associated with the final visual acuity. ConclusionsPoor presenting visual acuity, globe rupture and retinal detachment are the most important prognostic factors determining final visual acuity following open globe injury.
- Published
- 2021
3. Corneal biopsy for diagnosis of recalcitrant microbial keratitis
- Author
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Dana Robaei, Yi-Chiao Li, Svetlana Cherepanoff, Jane K Hanrahan, Pauline Khoo, U-Teng Chan, and Stephanie L Watson
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Time Factors ,Biopsy ,030106 microbiology ,Eye Infections, Bacterial ,Keratitis ,Cornea ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Young Adult ,0302 clinical medicine ,medicine ,Humans ,Fungal keratitis ,Aged ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,biology ,Bacteria ,business.industry ,Fungi ,Retrospective cohort study ,Middle Aged ,medicine.disease ,biology.organism_classification ,Dermatology ,Sensory Systems ,Acanthamoeba ,Contact lens ,Ophthalmology ,medicine.anatomical_structure ,030221 ophthalmology & optometry ,Histopathology ,Female ,business ,Eye Infections, Fungal ,Follow-Up Studies - Abstract
To document the findings of corneal biopsies for progressive microbial keratitis in a large tertiary referral institution. A retrospective medical records review of all patients who underwent at least one corneal biopsy for the diagnosis of microbial keratitis at Sydney Eye Hospital, Australia between January 1, 2010 and December 31, 2016 was performed. Thirty-eight patients (18 men and 20 women) underwent a corneal biopsy for progressive microbial keratitis unresponsive to broad-spectrum topical antimicrobials. Risk factors for microbial keratitis included contact lens wear in 8 (21%), recent intraocular surgery in 5 cases (13%), recent agricultural trauma in 3 cases (8%), exposure keratopathy due to Graves’ orbitopathy in 1 case (3%), and profound systemic immunosuppression due to chemotherapy for leukaemia in 1 case (3%). The remaining 20 patients had no identifiable risk factors. Fifteen patients (39%) had a positive biopsy result, which identified bacteria in 6 cases and Mycobacteria in 1 case, both by culture of the biopsy specimen. Three cases of fungus were identified on culture of biopsy specimen, two of which were also confirmed on histopathology and an additional case was identified from histopathology alone. A single case of Acanthamoeba was diagnosed by culture and histopathology, and an additional 3 cases were diagnosed on histopathology alone. A corneal biopsy yielded new organisms in 73% (11/15) cases where the culture results of biopsy specimens were positive. Corneal biopsy is an important tool in the diagnosis of progressive keratitis, often identifying causal organisms not found on corneal scraping alone.
- Published
- 2017
4. Changing refractive outcomes with increasing astigmatism at longer-term follow-up for infant cataract surgery
- Author
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Yi Chiao Li, John R. Grigg, N Kanapathipillai, and Chameen Samarawickrama
- Subjects
Male ,medicine.medical_specialty ,genetic structures ,Pseudophakia ,medicine.medical_treatment ,Glaucoma ,Intraocular lens ,Cataract Extraction ,Astigmatism ,Refraction, Ocular ,01 natural sciences ,Cataract ,Neuro-ophthalmology ,03 medical and health sciences ,0302 clinical medicine ,Lens Implantation, Intraocular ,Ophthalmology ,Medicine ,Humans ,0101 mathematics ,Strabismus ,Retrospective Studies ,business.industry ,010102 general mathematics ,Infant ,Retrospective cohort study ,Cataract surgery ,medicine.disease ,eye diseases ,Confidence interval ,030221 ophthalmology & optometry ,Clinical Study ,Female ,sense organs ,business ,Follow-Up Studies - Abstract
PurposeTo present longer-term refractive and ocular health outcomes for patients who had primary intraocular lens (IOL) insertion following infant cataract surgery.Patients and methodsA retrospective review of all infant cataract cases at a tertiary children's hospital between 2003 and 2006 was conducted. Surgery was performed before 12 months of age. IOL power was calculated using the SRK/T formula targeting hyperopia based on the child's age; children under 3 months were targeted at +9.0 D, between 3 and 6 months at +6.0 D, and between 6 and 12 months at +3.0 D. Locally weighted scatterplot smoothing and mixed models were used.ResultsA total of 12 eyes from 9 children were included (4 bilateral and 5 unilateral). Spherical equivalent refraction decreased dramatically in the first 2 years of life, with milder changes from age 2 to 4 years and minimal changes thereafter. Cylinder increased until age 5 years at ∼0.57 dioptres/year (95% confidence intervals 0.27-0.87 D, P
- Published
- 2016
5. Scleral tunnel intraocular lens explantation: comment
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Yi-Chiao, Li
- Subjects
Lenses, Intraocular ,Lens Implantation, Intraocular ,Humans ,Cataract Extraction ,Device Removal ,Sclera ,Surgical Flaps ,Prosthesis Failure - Published
- 2015
6. Orbital Involvement in Systemic Mastocytosis
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Dale Waring, Manju Meena, Irina Karnaukhvoa, Ross Benger, and Yi Chiao Li
- Subjects
Chemosis ,medicine.medical_specialty ,Visual acuity ,genetic structures ,Biopsy ,Visual Acuity ,Lacrimal gland ,Diagnosis, Differential ,Mastocytosis, Systemic ,Ophthalmology ,Orbital Diseases ,medicine ,Humans ,Systemic mastocytosis ,business.industry ,Middle Aged ,medicine.disease ,eye diseases ,Surgery ,Posterior segment of eyeball ,medicine.anatomical_structure ,Female ,Histopathology ,sense organs ,medicine.symptom ,Differential diagnosis ,Tomography, X-Ray Computed ,business - Abstract
A 61-year-old female presented with a 3-day history of painful and reddened right eye with painful ocular movements. She had been diagnosed as having systemic mastocytosis 4 years earlier. Ocular examination showed Best Corrected Visual acuity of 6/6 right eye and 6/6 left eye. There was marked conjunctival injection and chemosis. The posterior segment was normal. The left eye was normal. Exophthalmometry showed 2 mm of right proptosis relative to the left eye. Computed tomography (CT) scans showed an ill-defined intra-conal lesion and enlargement of the lacrimal gland in the right orbit. A diagnostic biopsy was performed; the histopathology findings were of orbital mastocytosis. We present what our literature search suggests is the first biopsy-proven case of orbital mastocytosis.
- Published
- 2014
7. Successful treatment of infantile haemangiomas of the orbit with propranolol
- Author
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Yi Chiao Li, Emma McCahon, Frank J. Martin, Neil A. Rowe, Geoffrey A. Wilcsek, and Peter A. Martin
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Propranolol ,Surgery ,body regions ,Lesion ,Ophthalmology ,medicine.anatomical_structure ,Infantile haemangioma ,Corticosteroid therapy ,medicine ,Older child ,medicine.symptom ,business ,β adrenergic antagonist ,Orbit (anatomy) ,medicine.drug - Abstract
Background: Propranolol is a novel therapeutic agent in the treatment of cutaneous infantile haemangiomas. We assessed the effect of propranolol therapy in infantile haemangiomas of the orbit. Methods: A case series of four patients with orbital infantile haemangiomas were referred for management in our tertiary referral hospitals. Two of the patients had inadequate responses to prior corticosteroid therapy. One of the patients was commenced on propranolol at 2.5 years of age when the lesion was not in the proliferative phase. This represented the first case report of propranolol treatment for infantile haemangioma outside infancy. The other three children were in their infancy when propranolol was commenced. The patients were treated with oral propranolol. Results: All patients had significant improvement in their physical appearance, ocular examination findings and size of their lesions on radiological evaluation. No side-effects of propranolol treatment were observed. Conclusions: Propranolol is a promising treatment against infantile haemangiomas in the orbit, not only in infants but also in an older child with a stable lesion.
- Published
- 2010
8. The Efficacy of N-Butyl-2 Cyanoacrylate (Histoacryl) for Sealing Corneal Perforation: A Clinical Case Series and Review of the Literature
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Jackie Tan, Yi-Chiao Li, Stephanie L Watson, and John Foster
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medicine.medical_specialty ,genetic structures ,business.industry ,Adhesion (medicine) ,Corneal irritation ,Corneal perforation ,medicine.disease ,eye diseases ,Surgery ,law.invention ,Keratitis ,medicine.anatomical_structure ,Cyanoacrylate ,law ,Cornea ,medicine ,Definitive surgery ,sense organs ,Clinical case ,business - Abstract
Purpose: To investigate the efficacy of corneal gluing procedures for corneal perforations of mixed aetiologies in a tertiary eye hospital in Sydney, Australia. Design: Retrospective case series. Methods: Episodes of corneal gluing procedures were identified from the Sydney Eye Hospital surgical database over 42 months from January 2010. All gluing procedures in this study were conducted in the operating theatre. Categorical variables were compared using Pearson’s chi-square test. Results: Forty-five episodes of corneal gluing using n-butyl-2-cyanoacrylate were identified from 30 eyes. 18 eyes were glued once, 9 eyes were glued twice and 3 eyes were glued thrice. The median duration of butylcyanoacrylate adhesion was 14 days, range 1 to 1945 days. Our data yielded an episodic success rate of 67% for nbutyl- 2-cyanoacrylate gluing when success was defined as the tissue adhesive sealing the leak until healing by scarring or until planned definitive surgery. Secondary outcomes included success rate by the location, aetiology, and size of the corneal perforation, and did not reach statistical significance. Of our 30 eyes treated with nbutyl- 2cyanoacrylate glue, 47% (n=14) did not require further surgical intervention and healed by scarring. The complications noted with n-butyl-2-cyanoacrylate use were cornea vascularisation (n=5), conjunctival and corneal irritation (n=2), and secondary microbial keratitis (n=1). Conclusions: Corneal gluing using n-butyl-2-cyanoacrylate was successful in 67% of episodes. Almost half of our eyes healed without surgical intervention. Corneal gluing, previously thought to be a temporising measure, is effective and can potentially be a definitive treatment.
- Published
- 2015
9. Generation of tumour-specific cytotoxic T-cell clones from histocompatibility leucocyte antigen-identical siblings of patients with melanoma
- Author
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Catia Traversari, David Gottlieb, Yi-Chiao Li, Kenneth F. Bradstock, V. Russo, Ilaria Lionello, Marina Marangolo, and Silvia Tanzarella
- Subjects
CD4-Positive T-Lymphocytes ,Cancer Research ,Lymphocyte ,medicine.medical_treatment ,T cells ,Biology ,Immunotherapy, Adoptive ,Epitopes ,Interferon-gamma ,Antigen ,HLA Antigens ,Cell Line, Tumor ,melanoma ,Tumor Cells, Cultured ,medicine ,Humans ,Cytotoxic T cell ,human ,tumour immunity ,Histocompatibility Testing ,Siblings ,Melanoma ,Immunotherapy ,Cytotoxicity Tests, Immunologic ,Donor Lymphocytes ,medicine.disease ,Clone Cells ,Transplantation ,medicine.anatomical_structure ,Oncology ,Immunology ,Translational Therapeutics ,CD8 ,transplantation ,Stem Cell Transplantation ,T-Lymphocytes, Cytotoxic - Abstract
Lymphodepletion and infusion of autologous expanded tumour-infiltrating lymphocytes is effective therapy for patients with malignant melanoma. Antitumour responses are likely to be mediated by HLA class I- and II-restricted immune responses directed at tumour antigens. We assessed whether the peripheral blood of normal HLA-matched siblings of patients with melanoma could be used to generate lymphocytes with antimelanoma activity for adoptive immunotherapy after allogeneic blood or marrow transplantation. Melanoma cell lines were derived from two donors and were used to stimulate the mononuclear cells of three HLA-identical siblings. CD4(+) clones dominated cultures. Of these, approximately half were directly cytotoxic towards recipient melanoma cells and secreted interferon-gamma in response to tumour stimulation. More than half of the noncytotoxic clones also secreted interferon-gamma after melanoma stimulation. No CD4(+) clones responded to stimulation with recipient haemopoietic cells. The majority of CD8(+) clones directly lysed recipient melanoma, but did not persist in long-term culture in vitro. No crossreactivity with recipient haemopoietic cells was observed. The antigenic target of one CD4(+) clone was determined to be an HLA-DR11-restricted MAGE-3 epitope. Antigenic targets of the remaining clones were not elucidated, but appeared to be restricted through a non-HLA-DR class II molecule. We conclude that the blood of allogeneic HLA-matched sibling donors contains melanoma-reactive lymphocyte precursors directed at tumour-associated antigens. Adoptive immunotherapy with unselected or ex vivo-stimulated donor lymphocytes after allogeneic stem cell transplantation has a rational basis for the treatment of malignant melanoma.
- Published
- 2006
10. Scleral tunnel intraocular lens explantation: comment
- Author
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Yi-Chiao Li
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Intraocular lens ,Sclera ,Cataract extraction ,Ophthalmology ,medicine.anatomical_structure ,Device removal ,medicine ,Surgical Flaps ,Scleral tunnel ,business - Published
- 2016
11. Rapid, Large-Scale Generation of Highly Pure Cytomegalovirus-Specific Cytotoxic T Cells for Adoptive Immunotherapy
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Kenneth F. Bradstock, Aaron E. Foster, David Gottlieb, Jose A. Romagnoli, Marina Marangolo, Geoffrey W. Barton, Anna Bartlett, and Yi-Chiao Li
- Subjects
Adoptive cell transfer ,Time Factors ,Immunology ,Adoptive immunotherapy ,Cell Culture Techniques ,Congenital cytomegalovirus infection ,Antigen-Presenting Cells ,Cytomegalovirus ,Genes, MHC Class I ,Enzyme-Linked Immunosorbent Assay ,chemical and pharmacologic phenomena ,Biology ,Immunotherapy, Adoptive ,Monocytes ,Immunophenotyping ,Viral Matrix Proteins ,Immunity ,medicine ,Humans ,Cytotoxic T cell ,Models, Genetic ,food and beverages ,virus diseases ,Dendrites ,Dendritic Cells ,Hematology ,Flow Cytometry ,Phosphoproteins ,medicine.disease ,Virology ,CTL ,Stem cell ,Peptides ,Stem Cell Transplantation ,T-Lymphocytes, Cytotoxic - Abstract
Adoptive transfer of donor-derived cytomegalovirus (CMV)-specific cytotoxic T cell (CTL) clones can restore immunity in allogeneic stem cell transplant recipients, providing protection against CMV disease. Current methods for selecting and expanding CMV-specific T cell clones are technically difficult, making adoptive T cell therapy impractical for routine clinical use. In this study, we describe a method for ex vivo generation and expansion of high-purity CMV-specific CTL using peptide-pulsed dendritic cells as antigen-presenting cells. Generation of CMV-specific CTL in numbers sufficient for clinical use in the time span of 4 weeks was accomplished in 6 of 8 CMV-seropositive donors. Examination of pp65 specificity by HLA/peptide tetramer staining demonstrated that a purity of greater than 95% peptide-specific cells could be obtained after two weekly stimulations and retained after further expansion for 3-4 weeks. Median expansion of total cell number was greater than 500-fold and expansion of peptide-specific CTL by tetramer staining was greater than 1.7 x 10(5)-fold. Four weeks after initiating CTL culture, we were able to generate greater than 10(9) total cells that specifically lysed target cells loaded with CMV peptide and cells infected with CMV. This simple and rapid method for generating high-purity CMV-specific CTL for adoptive immunotherapy is currently being examined for routine clinical use for allogeneic stem cell transplantation.
- Published
- 2003
12. Reducing oral contamination during corneal scrapes
- Author
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Stephanie L Watson, Mark D. P. Willcox, Debarun Dutta, Yi-Chiao Li, Nicole Carnt, and Chameen Samarawickrama
- Subjects
0303 health sciences ,medicine.medical_specialty ,business.industry ,Negative control ,Contamination ,corneal scrape ,Streptococcus species ,3. Good health ,Surgery ,Face masks ,Agar plate ,03 medical and health sciences ,Ophthalmology ,Surgical mask ,contamination ,0302 clinical medicine ,030221 ophthalmology & optometry ,medicine ,Original Article ,business ,030304 developmental biology - Abstract
Aims: To identify potential contaminants of the corneal sampling procedure and examine the effect of wearing surgical face masks on the rate of contamination. Methods: Ten surgeons recited out loud a 30 s standardised script for corneal scraping with blood agar plates positioned 30 cm away from them. Three groups were identified: in group 1 a surgical mask was worn; group 2 had no mask worn; and group 3 had no mask but used agar plates pretreated with 5% povidone-iodine as a negative control. Each surgeon repeated the process 10 times for all groups, totalling 30 plates per surgeon and 300 plates for the experiment. All plates were masked and incubated aerobically at 37°C for 24 hours, and the number of colony forming units (CFUs) was determined. Results: At 24 hours, group 1 had a mean of 0.3 CFUs per surgeon; group 2 had 6.4 CFUs per surgeon and group 3 had 0.1 CFUs per surgeon. The difference between group 1 and group 2 was significant (p
- Published
- 2017
13. Hazardous contact: A case of visual loss following Pseudomonas keratitis from novelty contact lens wear
- Author
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Yi-Chiao Li, Zeldovich, Alina, Chua, Brian J., Rowe, Neil J., Martin, Frank J., and McClellan, Kathleen A.
- Subjects
Keratitis -- Risk factors ,Contact lenses -- Usage ,Contact lenses -- Complications and side effects ,Health - Abstract
Poor contact lens hygiene, is a well-known risk factor for Pseudomonas keratitis, a potentially vision destroying infection common among contact lens wearers. It is advised that contact lens wearers should be properly educated regarding contact lens handling, hygiene and made aware of the serious risk of keratitis.
- Published
- 2006
14. Successful treatment of infantile haemangiomas of the orbit with propranolol
- Author
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Yi-Chiao, Li, Emma, McCahon, Neil A, Rowe, Peter A, Martin, Geoffrey A, Wilcsek, and Frank J, Martin
- Subjects
Male ,Child, Preschool ,Adrenergic beta-Antagonists ,Humans ,Infant ,Orbital Neoplasms ,Female ,Hemangioma ,Magnetic Resonance Imaging ,Propranolol - Abstract
Propranolol is a novel therapeutic agent in the treatment of cutaneous infantile haemangiomas. We assessed the effect of propranolol therapy in infantile haemangiomas of the orbit.A case series of four patients with orbital infantile haemangiomas were referred for management in our tertiary referral hospitals. Two of the patients had inadequate responses to prior corticosteroid therapy. One of the patients was commenced on propranolol at 2.5 years of age when the lesion was not in the proliferative phase. This represented the first case report of propranolol treatment for infantile haemangioma outside infancy. The other three children were in their infancy when propranolol was commenced. The patients were treated with oral propranolol.All patients had significant improvement in their physical appearance, ocular examination findings and size of their lesions on radiological evaluation. No side-effects of propranolol treatment were observed.Propranolol is a promising treatment against infantile haemangiomas in the orbit, not only in infants but also in an older child with a stable lesion.
- Published
- 2010
15. Ex-vivo uses and applications of cytokines for adoptive immunotherapy in cancer
- Author
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Aaron E. Foster, Yi-Chiao Li, David Gottlieb, and Kurt Forrester
- Subjects
Adoptive cell transfer ,animal diseases ,medicine.medical_treatment ,Antigen-Presenting Cells ,chemical and pharmacologic phenomena ,Biology ,Immunotherapy, Adoptive ,Immune system ,Antigen ,Neoplasms ,Drug Discovery ,medicine ,Animals ,Humans ,Pharmacology ,CCL18 ,Immunotherapy ,Dendritic Cells ,biochemical phenomena, metabolism, and nutrition ,Acquired immune system ,Cytokine ,Immunology ,bacteria ,Cytokines ,Ex vivo ,T-Lymphocytes, Cytotoxic - Abstract
Harnessing the power of the immune system to eliminate infection and cancer is a long-standing goal in clinical immunology. The development of a robust immune response to foreign antigen relies, in part, on communication between cellular components of the immune system. The proteins involved in governing the magnitude and longevity of an immune response are collectively called cytokines. Cytokines act directly on immune cells to induce proliferation, differentiation and tolerance, and signaling errors can lead to autoimmune disease or immune deficiency. Identification of the molecules involved in these signaling processes has allowed investigators to manipulate immune cells for therapeutic effect, both in vivo and ex vivo. While in vivo immune modulation using cytokines has produced some exciting results, the toxicity involved with systemic administration has limited their broad use in the clinic. Therefore, research has been focused on the ex vivo manipulation of immune cells for adoptive transfer to treat cancer and infection. This review will focus on the ex vivo manipulation of immune cells with particular emphasis on stimulating cytotoxic T cell responses. Adoptive transfer of ex vivo generated cell types may then be used to treat malignant and viral disease.
- Published
- 2004
16. Hazardous contact: a case of visual loss following Pseudomonas keratitis from novelty contact lens wear
- Author
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Brian J. Chua, Frank J. Martin, Yi Chiao Li, Neil Rowe, Kathleen A. McClellan, and Alina Zeldovich
- Subjects
medicine.medical_specialty ,Adolescent ,Blindness ,Contact Lenses ,business.industry ,Vision Disorders ,General Medicine ,Silicone hydrogel ,medicine.disease ,corneal ulcer ,law.invention ,Keratitis ,Lens (optics) ,Contact lens ,law ,Ophthalmology ,medicine ,Humans ,Optometry ,Female ,Pseudomonas Infections ,Significant risk ,Medical journal ,Corneal Ulcer ,business - Abstract
The Medical Journal of Australia ISSN: 0025-729X 7 August 2006 3 185 173-174©The Medical Journal of Australia 2006www.mja.com.auLessons from Practiceeratitis remains a significant risk of wearing contact lenses,despite advances over the past 10 years such as disposableand silicone hydrogel lenses. The incidence of severekeratitis from extended hydrogel lens wear was estimated at 96.4(95% CI, 37.5–254.2) per 10000 lens wearers in a British study.
- Published
- 2006
17. Echinacoside Isolated from Cistanche tubulosa Putatively Stimulates Growth Hormone Secretion via Activation of the Ghrelin Receptor
- Author
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Chieh-Ju Wu, Mei-Yin Chien, Nan-Hei Lin, Yi-Chiao Lin, Wen-Ying Chen, Chao-Hsiang Chen, and Jason T. C. Tzen
- Subjects
cistanche tubulosa ,echinacoside ,ghrelin ,growth hormone secretion ,phenylethanoid glycosides ,Organic chemistry ,QD241-441 - Abstract
Cistanche species, the ginseng of the desert, has been recorded to possess many biological activities in traditional Chinese pharmacopoeia and has been used as an anti-aging medicine. Three phenylethanoid glycosides—echinacoside, tubuloside A, and acteoside—were detected in the water extract of Cistanche tubulosa (Schenk) R. Wight and the major constituent, echinacoside, was further purified. Echinacoside of a concentration higher than 10−6 M displayed significant activity to stimulate growth hormone secretion of rat pituitary cells. Similar to growth hormone-releasing hormone-6, a synthetic analog of ghrelin, the stimulation of growth hormone secretion by echinacoside was inhibited by [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P, an inverse agonist of the ghrelin receptor. Molecular modeling showed that all the three phenylethanoid glycosides adequately interacted with the binding pocket of the ghrelin receptor, and echinacoside displayed a slightly better interaction with the receptor than tubuloside A and acteoside. The results suggest that phenylethanoid glycosides, particularly echinacoside, are active constituents putatively responsible for the anti-aging effects of C. tubulosa and may be considered to develop as non-peptidyl analogues of ghrelin.
- Published
- 2019
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