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Federated learning (FL) has been widely studied as an emerging privacy-preserving machine learning paradigm for achieving multi-party collaborative model training on decentralized data. In practice, such data tend to follow non-independent and identically distributed (non-IID) data distributions. Thus, the performance of models obtained through vanilla horizontal FL tends to vary significantly across FL clients. To tackle this challenge, a new subfield of FL – personalized federated learning (PFL) – has emerged for producing personalized FL models that can perform well on diverse local datasets. Existing PFL approaches are limited in terms of effectively transferring knowledge among clients to improve model generalization while achieving good performance on diverse local datasets. To bridge this important gap, we propose the p ersonalized Fed erated K nowledge T ransfer (pFedKT) approach. It involves dual knowledge transfer: (1) transferring historical local knowledge to local models via local hypernetworks; and (2) transferring latest global knowledge to local models through contrastive learning. By fusing historical local knowledge and the latest global knowledge, the personalization and generalization of individual models for FL clients can be simultaneously enhanced. We provide theoretical analysis on the generalization and convergence of pFedKT. Extensive experiments on 3 real-world datasets demonstrate that pFedKT achieves 0.74%–1.62% higher test accuracy compared to 14 state-of-the-art baselines. [ABSTRACT FROM AUTHOR]

Climate change may lead to emerging and re-emerging infectious diseases and pose public health challenges to human health and the already overloaded healthcare system. It is therefore important to review current knowledge and identify further directions in China, the largest developing country in the world. A comprehensive literature review was conducted to examine the relationship between climate variability and infectious disease transmission in China in the new millennium. Literature was identified using the following MeSH terms and keywords: climatic variables [temperature, precipitation, rainfall, humidity, etc.] and infectious disease [viral, bacterial and parasitic diseases]. Fifty-eight articles published from January 1, 2000 to May 30, 2018 were included in the final analysis, including bacterial diarrhea, dengue, malaria, Japanese encephalitis, HFRS, HFMD, Schistosomiasis. Each 1 °C rise may lead to 3.6%–14.8% increase in the incidence of bacillary dysentery disease in south China. A 1 °C rise was corresponded to an increase of 1.8%–5.9% in the weekly notified HFMD cases in west China. Each 1 °C rise of temperature, 1％ rise in relative humidity and one hour rise in sunshine led to an increase of 0.90%, 3.99% and 0.68% in the monthly malaria cases, respectively. Climate change with the increased temperature and irregular patterns of rainfall may affect the pathogen reproduction rate, their spread and geographical distribution, change human behavior and influence the ecology of vectors, and increase the rate of disease transmission in different regions of China. Exploring relevant adaptation strategies and the health burden of climate change will assist public health authorities to develop an early warning system and protect China's population health, especially in the new 1.5 °C scenario of the newly released IPCC special report. • Many infectious diseases such as malaria and dengue fever are mostly affected by climate variability and climate change. • The impact of climate change on infectious disease transmission may be more prevalent in southern cities of China. • More infectious studies with multiple-locations and a long study period as well as adaptation strategies are required. [ABSTRACT FROM AUTHOR]

Ce 3+ , Mn 2+ codoped and Ce 3+ , RE 3+ , Mn 2+ (RE 3+ = Tb 3+ , La 3+ , Gd 3+ , Lu 3+ ) codoped Ca 5 (BO 3 ) 3 F phosphors have been synthesized by a high-temperature solid-state reaction. Crystal structure and site occupancy of the doped ions were determined by Rietveld refinement. Photoluminescence (PL) spectra as well as fluorescence lifetimes were investigated. Under the excitation of 360 nm, Ca 5 (BO 3 ) 3 F:Ce 3+ , Mn 2+ phosphors show a strong emission band at 392 nm and a very weak emission band at ∼630 nm, which belong to Ce 3+ and Mn 2+ , respectively. The introduction of Tb 3+ and even non-luminescent ions such as La 3+ , Gd 3+ and Lu 3+ to the Ce 3+ , Mn 2+ codoped phosphors leads to the enhancement of Mn 2+ emission. The analyses of fluorescence lifetimes suggest that there is energy transfer from Ce 3+ and especially Tb 3+ to Mn 2+ . However, Rietveld refinement results indicate that the introduction of RE 3+ ions leads to the adjustment of Mn 2+ ions from Ca(3) site to Ca(2) site, which is the key factor for the enhancement of Mn 2+ emission. The crystal-site engineering is expected to provide a promising route to tune the luminescent properties of phosphors with more than one site for activators. [ABSTRACT FROM AUTHOR]

Background: Nonpharmaceutical interventions (NPIs) targeted at SARS‐CoV‐2 have remarkably affected the circulation of other respiratory pathogens, including respiratory syncytial virus (RSV). This study aimed to assess the changes in epidemiological and clinical characteristics of RSV infections in hospitalized children before and during the pandemic in Suzhou, China. Methods: We prospectively enrolled children aged < 18 years who were hospitalized in Soochow University Affiliated Children's Hospital with acute lower respiratory infection (ALRIs) from January 2018 to July 2022. Changes in epidemiological and clinical characteristics of RSV infections were analyzed. Results: Compared with the same period in 2018–2019, the difference in the overall positive rate of RSV was not statistically significant in 2020, while it increased significantly in 2021 (11.8% [662/5621] vs. 20.8% [356/1711], p < 0.001) and 2022 (9.0% [308/3406] vs. 18.9% [129/684], p < 0.001). Specifically, the positive rates declined considerably from October to December 2020 but sharply increased during the summer of 2021. Compared to prepandemic period, RSV infections were more frequently observed in older children during the pandemic. RSV‐positive children exhibited milder clinical characteristics during the COVID‐19 pandemic, including decreased proportion of patients with hospital stay ≥ 11 days (10.3% vs. 6.7%, p < 0.05), less requirement for oxygen therapy (13.7% vs. 6.9%, p < 0.001), and fewer cases of polypnea (12.2% vs. 9.7%, p < 0.05) and wheeze (50.1% vs. 42.9%, p < 0.001). Conclusions: The implementation of multilayered NPIs targeted at COVID‐19 has affected the activity of RSV. Ongoing monitoring of RSV is warranted as the changing RSV epidemiology can provide valuable insights for future healthcare system planning. [ABSTRACT FROM AUTHOR]

The approval of nirsevimab brings light to reducing the heavy disease burden caused by respiratory syncytial virus (RSV). Considering the seasonality of RSV, the timing of administrating monoclonal antibody (mAb) is critical to maximize health utility. This study aimed to model and seek the optimal seasonal mAb administration strategy for preventing RSV-associated hospitalization. Age-season specific hospitalization rates for RSV-associated acute lower respiratory infection (RSV-ALRI) were estimated from a hospital-based birth cohort. Using these rates, we simulated and evaluated the effect of diverse mAb administration strategies on preventing RSV-ALRI hospitalization. Optimal strategies were selected based on their effectiveness and relative cost-effectiveness. Compared with the year-round strategy of administration mAb at birth for all children, 291 out of the 854 candidate strategies, featuring diverse administration timing and age thresholds, demonstrated a greater number of averted RSV-ALRI hospitalizations and a lower number needed to treat (NNT). The NNT represents the number of mAb doses needed to prevent one case of RSV-ALRI hospitalization. Among the 291 strategies, administration mAb to children born in July-January or August-January at birth and administrating to the remaining <12 months old children in September, exhibited the highest increase in averted RSV-ALRI hospitalizations than the year-round strategy, with a magnitude of 23 %, while also achieve an 18 % reduction in NNT. Administrating monoclonal antibodies to children born in July to January at birth, and administrating to the remaining <1-year-old children in September or October would be the optimal seasonal mAb administration strategy for children in Suzhou, China. [ABSTRACT FROM AUTHOR]

Introduction: The COVID-19 pandemic‒related BMI gain and obesity prevalence changes in children have not been clearly elucidated, especially in China. This study aims to assess the impact of pandemic-related BMI and obesity prevalence change in Chinese children aged 8-12 years.Methods: On the basis of the Health Promotion Program for Children and Adolescents in Suzhou of China, a total of 72,175 children aged 8-12 years with complete data during 2017-2020 were included. Yearly BMI z-score changes and age- and sex-adjusted BMI changes before (2017-2019) and during (2019-2020) the pandemic were calculated. Multivariate mixed linear models were used to examine the possible difference in annual BMI change rate before and during the pandemic among subgroups.Results: The obesity prevalence slightly increased from 12.29% (2017) to 13.28% (2019) but substantially increased to 15.29% in 2020. The mean yearly change in BMI z-score before and during the pandemic were 0.039 (95% CI=0.037, 0.042) and 0.131 (95% CI=0.125, 0.138), respectively, yielding a difference of 0.092 (95% CI=0.087, 0.096). Similarly, changes and age- and sex-adjusted BMI increased by 0.191 (95% CI=0.179, 0.202) during the pandemic compared with those of previous years. Meanwhile, the increase in BMI changes in 2019-2020 compared with that before the pandemic was more obvious in boys than in girls and in underweight or normal-weight children than in their overweight and obese counterparts.Conclusions: BMI gain increased among Chinese children aged 8-12 years during the pandemic. There is an urgent need to formulate effective public health policies to reduce the risk of pandemic-related childhood obesity. [ABSTRACT FROM AUTHOR]

Introduction: This study aimed to explore the association between the IRAK4 polymorphism rs4251545 and the severity of enterovirus 71 (EV71) infection in Chinese children. Methods: We analyzed the IRAK4 polymorphism rs4251545 in 617 EV71‐infected patients and 410 controls using the improved multiplex ligation detection reaction. IRAK4 mRNA expression was tested by qRT‐PCR. Serum concentrations of IL‐6 and NF‐κB were detected using ELISA. Results: The frequencies of the GA + AA genotype and A allele in the mild EV71 infection group and in the severe EV71 infection group were significantly higher than those in the normal control group. The frequency of the GA + AA genotype and A allele in severely infected EV71 patients was markedly higher than that in mildly infected EV71 patients. IRAK4 mRNA expression in mildly infected EV71 patients and severely infected patients was significantly higher than that in the control group. IRAK4 mRNA expression in GA + AA genotypes in both mild and severe EV71 infection groups was significantly higher than that in patients with the GG genotype. IL‐6 concentration and the ratio of IL‐6/NF‐κB in severe EV71 cases were significantly lower in patients with the GA + AA genotype than in those with the GG genotype. The ratio of IL‐6/NF‐κB was distinctly higher in severely infected EV71 patients than in mildly infected and control subjects. Conclusions: The IRAK4 polymorphism rs4251545 was associated with the susceptibility and severity of EV71 infection. The A allele is a susceptible factor in the development of severe EV71 infection in Chinese children. [ABSTRACT FROM AUTHOR]

Polycystic kidney disease with Tuberous sclerosis is a disease caused by the deletions of the TSC2‐PKD1 gene. The disease is rarely reported and the characterized manifestation is severe polycystic kidney growth. The diagnosis can be made by molecular analysis. We report the first case of PKDTS discovered in infancy in China with typical neurological and renal manifestations. The patient has infantile spasm, polycystic kidney, skin damage, hypertension, and hematuria after infection. After effective treatment of Rapamycin, the seizures were completely controlled. There was not been any renal function damage in the patient. At the same time, we review the related literature and further elaborate on the variety of clinical manifestations, treatment, and prognosis. [ABSTRACT FROM AUTHOR]

Environmental scenarios around the Cenomanian-Turonian ocean anoxic event (OAE2) interval are scarcely studied in the southeastern Neo-Tethys and not discussed in terms of variation of primary mineralogies of marine carbonates. Based on petrological and geochemical analyses, this study focuses on the increased aragonite abundance in the oxygen-decreasing interval before the OAE2 and its environmental implications in the southeastern Neo-Tethys. In central Iraq, the upper Cenomanian-lower Turonian Mishrif Formation represents marine carbonate records in the southeastern, tropical Neo-Tethys and includes five members from the lowermost Mi-5 to the uppermost Mi-1. From Mi-5 to Mi-1, dominant carbonate components and primary carbonate mineralogies vary. Mi-5 is dominated by primarily calcitic grains (mainly calcite shells of rudists and echinoids); Mi-4 and Mi-3 dominated by primarily aragonitic grains (mainly green algae and aragonitic bivalves) and planktonic calcitic foraminifera; and Mi-1 dominated by primarily calcitic ooids. Paleoenvironmental interpretations suggest: i) open marine, offshore settings for Mi-5 to Mi-3, and a shallow marine shoal setting for Mi-1; ii) a sea level rise from Mi-5 to Mi-3, followed by a sea level fall to Mi-1. The increasing aragonite abundance in Mi-4 and Mi-3 is exceptional and suggested to most likely reflect enhanced preservation of shallow-marine aragonite transported into open marine offshore settings. This enhanced aragonite preservation is likely related to an oxygen-decreasing level before the OAE2 in the offshore settings. Remarkably, these primarily aragonitic components are commonly preserved now as moldic pores in Mi-4 and Mi-3. The moldic pores are interpreted to be produced via deep burial dissolution of recrystallized aragonitic grains, based on petrological and geochemical analyses. Moreover, the primary carbonate compositional and mineralogical changes from Mi-5 to Mi-1 provide some potential clues for the environmental scenarios around the OAE2 interval in the southeastern, tropical Neo-Tethys: i) from Mi-5 to Mi-4 and Mi-3, the increasing abundance of primarily aragonitic components is accompanied by a sea level rise, increasing seawater temperature and decreasing oxygen level of bottom water; ii) from Mi-3 to Mi-1, the decreasing abundance of primarily aragonitic components is accompanied by a sea level fall, decreasing seawater temperature and enhanced microbial carbonate production. [ABSTRACT FROM AUTHOR]