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749 results on '"Yi, Dahyun"'

1. Brain aging patterns in a large and diverse cohort of 49,482 individuals

Author

Yang, Zhijian, Wen, Junhao, Erus, Guray, Govindarajan, Sindhuja T., Melhem, Randa, Mamourian, Elizabeth, Cui, Yuhan, Srinivasan, Dhivya, Abdulkadir, Ahmed, Parmpi, Paraskevi, Wittfeld, Katharina, Grabe, Hans J., Bülow, Robin, Frenzel, Stefan, Tosun, Duygu, Bilgel, Murat, An, Yang, Yi, Dahyun, Marcus, Daniel S., LaMontagne, Pamela, Benzinger, Tammie L. S., Heckbert, Susan R., Austin, Thomas R., Waldstein, Shari R., Evans, Michele K., Zonderman, Alan B., Launer, Lenore J., Sotiras, Aristeidis, Espeland, Mark A., Masters, Colin L., Maruff, Paul, Fripp, Jurgen, Toga, Arthur W., O’Bryant, Sid, Chakravarty, Mallar M., Villeneuve, Sylvia, Johnson, Sterling C., Morris, John C., Albert, Marilyn S., Yaffe, Kristine, Völzke, Henry, Ferrucci, Luigi, Nick Bryan, R., Shinohara, Russell T., Fan, Yong, Habes, Mohamad, Lalousis, Paris Alexandros, Koutsouleris, Nikolaos, Wolk, David A., Resnick, Susan M., Shou, Haochang, Nasrallah, Ilya M., and Davatzikos, Christos

Published
2024
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11. Moderation of Amyloid-β Deposition on the Effect of Cholinesterase Inhibitors on Cognition in Mild Cognitive Impairment.

Author

Byeon, Gihwan, Byun, Min Soo, Yi, Dahyun, Ahn, Hyejin, Jung, Gijung, Lee, Yun-Sang, Kim, Yu Kyeong, Kang, Koung Mi, Sohn, Chul-Ho, and Lee, Dong Young

Subjects
MILD cognitive impairment, ALZHEIMER'S disease, CHOLINESTERASE inhibitors, COGNITION disorders, NEUROPSYCHOLOGICAL tests, CEREBRAL amyloid angiopathy
Abstract

Background: Clinical trial findings on cholinesterase inhibitors (ChEIs) for mild cognitive impairment (MCI) are inconclusive, offering limited support for their MCI treatment. Given that nearly half of amnestic MCI cases lack cerebral amyloid-β (Aβ) deposition, a hallmark of Alzheimer's disease; this Aβ heterogeneity may explain inconsistent results. Objective: This study aimed to assess whether Aβ deposition moderates ChEI effects on amnestic MCI cognition. Methods: We examined 118 individuals with amnestic MCI (ages 55–90) in a longitudinal cohort study. Baseline and 2-year follow-up assessments included clinical evaluations, neuropsychological testing, and multimodal neuroimaging. Generalized linear models were primarily analyzed to test amyloid positivity's moderation of ChEI effects on cognitive change over 2 years. Cognitive outcomes included Mini-Mental Status Examination score, the total score of the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery, and Clinical Dementia Rating-sum of boxes. Results: The analysis found no significant ChEI use x amyloid positivity interaction for all cognitive outcomes. ChEI use, irrespective of Aβ status, was associated with more cognitive decline over the 2-year period. Conclusions: Aβ pathology does not appear to moderate ChEI effects on cognitive decline in MCI. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Cognitive reserve proxies, Alzheimer pathologies, and cognition

Author

Ko, Kang, Yi, Dahyun, Byun, Min Soo, Lee, Jun Ho, Jeon, So Yeon, Kim, Woo Jin, Byeon, Gihwan, Sung, Kiyoung, Han, Dongkyun, Lee, Younghwa, Joung, Haejung, Jung, Gijung, Lee, Jun-Young, Kim, Heejung, Kim, Yu Kyeong, Kang, Koung Mi, Sohn, Chul-Ho, Lee, Dong Young, and for the KBASE research group

Published
2021
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18. Tau pathway‐based gene analysis in the Alzheimer’s disease continuum identifies CLU and FYN associated with tau deposition on PET in a Korean Cohort

Author

Yi, Dahyun, primary, Nho, Kwangsik, additional, Byun, Min Soo, additional, Jung, Gijung, additional, Ahn, Hyejin, additional, Lee, Yun‐Sang, additional, Kim, Jong‐Won, additional, Park, Jong‐Ho, additional, Liu, Shiwei, additional, Huang, Yen‐Ning, additional, Saykin, Andrew J., additional, and Lee, Dong Young, additional

Published
2023
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19. Association of Polygenic Risk Score of Alzheimer’s disease with A/T/N Biomarkers and Cognitive Decline

Author

Jung, Joon Hyung, primary, Byun, Min Soo, additional, Yi, Dahyun, additional, Jung, Gijung, additional, Ahn, Hyejin, additional, Liu, Shiwei, additional, Huang, Yen‐Ning, additional, Griswold, Anthony J., additional, Pericak‐Vance, Margaret A. A, additional, Kim, Yu Kyeong, additional, Lee, Yun‐Sang, additional, Sohn, Chul‐Ho, additional, Kang, Koung Mi, additional, Lee, Jun‐Young, additional, Saykin, Andrew J., additional, Nho, Kwangsik, additional, and Lee, Dong Young, additional

Published
2023
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20. Neurodegenerative biomarkers of A‐T+ compared to A+T+ and A‐T‐ older adults

Author

Jung, Joon Hyung, primary, Yi, Dahyun, additional, Byun, Min Soo, additional, Kong, Nayeong, additional, Chang, Yoon Young, additional, Keum, Musung, additional, Jung, Gijung, additional, Ahn, Hyejin, additional, Lee, Jun‐Young, additional, Lee, Yun‐Sang, additional, Kim, Yu Kyeong, additional, Kang, Kyoung Mi, additional, Sohn, Chul‐Ho, additional, and Lee, Dong Young, additional

Published
2023
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21. Tau pathology relates to regional microstructural alterations of cerebral white matter in older adults with diverse cognitive spectrum

Author

Kong, Nayeong, primary, Yi, Dahyun, additional, Byun, Min Soo, additional, Jung, Joon Hyung, additional, Chang, Yoon Young, additional, Keum, Musung, additional, Jung, Gijung, additional, Ahn, Hyejin, additional, Lee, Jun‐Young, additional, Lee, Yun‐Sang, additional, Kim, Yu Kyeong, additional, Kang, Koung Mi, additional, Sohn, Chul‐Ho, additional, and Lee, Dong Young, additional

Published
2023
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22. Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities

Author

Cha, Woo‐Jin, primary, Yi, Dahyun, additional, Ahn, Hyejin, additional, Byun, Min Soo, additional, Jung, Joon Hyung, additional, Kong, Nayeong, additional, Jung, Gijung, additional, Lee, Jun‐Young, additional, Lee, Yun‐Sang, additional, Kim, Yu Kyeong, additional, Kang, Koung Mi, additional, Sohn, Chul‐Ho, additional, and Lee, Dong Young, additional

Published
2023
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23. Relationship of diffusion weighted imaging of the hippocampal cingulum and cognition across the Alzheimer’s disease continuum

Author

Hirschfeld, Lauren Rose, primary, Chumin, Evgeny J., additional, Deardorff, Rachael, additional, Wu, Yu‐Chien, additional, Risacher, Shannon L, additional, Yi, Dahyun, additional, Byun, Min Soo, additional, Lee, Jun‐Young, additional, Kim, Yu Kyeong, additional, Kang, Koung Mi, additional, Sohn, Chul‐Ho, additional, Nho, Kwangsik, additional, Saykin, Andrew J., additional, and Lee, Dong Young, additional

Published
2023
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24. Herpes Simplex Virus Infection and in vivo Alzheimer’s Disease Pathologies

Author

Chang, Yoon Young, primary, Byun, Min Soo, additional, Yi, Dahyun, additional, Ahn, Hyejin, additional, Kim, Min Jung, additional, Jung, Joon Hyung, additional, Kong, Nayeong, additional, Sohn, Bo Kyung, additional, Lee, Jun‐Young, additional, Kim, Yu Kyeong, additional, Lee, Yun‐Sang, additional, Kang, Koung Mi, additional, Sohn, Chul‐Ho, additional, and Lee, Dong Young, additional

Published
2023
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27. Genome‐wide association meta‐analysis identifies a novel LRBA locus for brain age acceleration in two independent Korean Cohorts

Author

Kim, Bo‐Hyun, primary, Nho, Kwangsik, additional, Huang, Yen‐Ning, additional, Risacher, Shannon L, additional, Kim, Jun Pyo, additional, Yi, Dahyun, additional, Byun, Min Soo, additional, Kim, Hee Jin, additional, Won, Hong‐Hee, additional, Saykin, Andrew J., additional, Lee, Dong Young, additional, and Seo, Sang Won, additional

Published
2023
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28. In vivo tau deposition in the brain stem nuclei and circadian rest‐activity rhythm change in non‐demented older adults

Author

Jeon, So Yeon, primary, Yi, Dahyun, additional, Byun, Min Soo, additional, Jung, Joon Hyung, additional, Kong, Nayeong, additional, Chang, Yoon Young, additional, Keum, Musung, additional, Jung, Gijung, additional, Ahn, Hyejin, additional, Lee, Jun‐Young, additional, Lee, Yun‐Sang, additional, Kim, Yu Kyeong, additional, Kang, Koung Mi, additional, Sohn, Chul‐Ho, additional, and Lee, Dong Young, additional

Published
2023
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29. Association between known Alzheimer’s disease risk loci and in vivo brain amyloid pathology in a Korean Cohort

Author

Ahn, Hyejin, primary, Byun, Min Soo, additional, Yi, Dahyun, additional, Jung, Gijung, additional, Huang, Yen‐Ning, additional, Griswold, Anthony J., additional, Pericak‐Vance, Margaret A. A, additional, Kim, Yu Kyeong, additional, Lee, Yun‐Sang, additional, Sohn, Chul‐Ho, additional, Kang, Koung Mi, additional, Lee, Jun‐Young, additional, Saykin, Andrew J., additional, Nho, Kwangsik, additional, and Lee, Dong Young, additional

Published
2023
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36. Novel Alzheimer’s disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers

Author

Park, Jong-Ho, Park, Inho, Youm, Emilia Moonkyung, Lee, Sejoon, Park, June-Hee, Lee, Jongan, Lee, Dong Young, Byun, Min Soo, Lee, Jun Ho, Yi, Dahyun, Chung, Sun Ju, Park, Kye Won, Choi, Nari, Kim, Seong Yoon, Yoon, Woon, An, Hoyoung, Kim, Ki woong, Choi, Seong Hye, Jeong, Jee Hyang, Kim, Eun-Joo, Kang, Hyojin, Lee, Junehawk, Kim, Younghoon, Lee, Eunjung Alice, Seo, Sang Won, Na, Duk L., and Kim, Jong-Won

Published
2021
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37. Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities.

Author

Cha, Woo-Jin, Yi, Dahyun, Ahn, Hyejin, Byun, Min Soo, Chang, Yoon Young, Choi, Jung-Min, Kim, Kyungtae, Choi, Hyeji, Jung, Gijung, Kang, Koung Mi, Sohn, Chul-Ho, Lee, Yun-Sang, Kim, Yu Kyeong, and Lee, Dong Young

Abstract

Background: Growing evidence suggests that not only cerebrovascular disease but also Alzheimer’s disease (AD) pathological process itself cause cerebral white matter degeneration, resulting in white matter hyperintensities (WMHs). Some preclinical evidence also indicates that white matter degeneration may precede or affect the development of AD pathology. This study aimed to clarify the direction of influence between in vivo AD pathologies, particularly beta-amyloid (Aβ) and tau deposition, and WMHs through longitudinal approach. Methods: Total 282 older adults including cognitively normal and cognitively impaired individuals were recruited from the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE) cohort. The participants underwent comprehensive clinical and neuropsychological assessment, [11C] Pittsburgh Compound B PET for measuring Aβ deposition, [18F] AV-1451 PET for measuring tau deposition, and MRI scans with fluid-attenuated inversion recovery image for measuring WMH volume. The relationships between Aβ or tau deposition and WMH volume were examined using multiple linear regression analysis. In this analysis, baseline Aβ or tau were used as independent variables, and change of WMH volume over 2 years was used as dependent variable to examine the effect of AD pathology on increase of WMH volume. Additionally, we set baseline WMH volume as independent variable and longitudinal change of Aβ or tau deposition for 2 years as dependent variables to investigate whether WMH volume could precede AD pathologies. Results: Baseline Aβ deposition, but not tau deposition, had significant positive association with longitudinal change of WMH volume over 2 years. Baseline WMH volume was not related with any of longitudinal change of Aβ or tau deposition for 2 years. We also found a significant interaction effect between baseline Aβ deposition and sex on longitudinal change of WMH volume. Subsequent subgroup analyses showed that high baseline Aβ deposition was associated with increase of WMH volume over 2 years in female, but not in male. Conclusions: Our findings suggest that Aβ deposition accelerates cerebral WMHs, particularly in female, whereas white matter degeneration appears not influence on longitudinal Aβ increase. The results also did not support any direction of influence between tau deposition and WMHs. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Modulatory effect of blood LDL cholesterol on the association between cerebral Aβ and tau deposition in older adults

Author

Han, Seung Min, primary, Byun, Min Soo, additional, Yi, Dahyun, additional, Jung, Joon Hyung, additional, Kong, Nayeong, additional, Chang, Yoonyoung, additional, Keum, Musung, additional, Jung, Gi Jung, additional, Lee, Jun-Young, additional, Lee, Yun-Sang, additional, Kim, Yu Kyeong, additional, Kang, Koung Mi, additional, Sohn, Chul-Ho, additional, and Lee, Dong Young, additional

Published
2023
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48. Development of a Cognitive Composite for Preclinical Alzheimer's Disease in Korean Older Adults.

Author

Kim, Minjae, Yi, Dahyun, Byun, Min Soo, Ahn, Hyejin, Jung, Joon Hyung, Kong, Nayeong, Chang, Yoonyoung, Choi, Hyeji, Choi, Jungmin, Kim, Kyungtae, Jung, Gijung, and Lee, Dong Young

Subjects
*ALZHEIMER'S disease, *OLDER people, *COGNITIVE development, *STROOP effect, *EPISODIC memory, *FLUENCY (Language learning), AGE factors in cognition disorders
Abstract

Background: As tracking subtle cognitive declines in the preclinical stage of Alzheimer's disease (AD) is difficult with traditional individual outcome measures, need for cognitive composite for preclinical AD is widely recognized. Objective: We aimed to develop culturally appropriate cognitive composite that sensitively identifies subtle cognitive decline of preclinical AD in Korean older adults. Methods: A total 225 cognitively normal elderly individuals from the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease, were included. Tests of episodic memory, orientation, and executive function were carefully selected through review of previously established composites. Three candidate composites including Consortium to Establish a Registry for Alzheimer's Disease Word list recall (WLR), Logical memory (LM) II, and Mini-Mental status examination (MMSE) in common, and Letter fluency test (LF), category fluency test, or Stroop color and word test, were selected. Results: Student t-tests demonstrated that only the composite composed of WLR, LM II, MMSE, and LF (Composite 1) showed a significant difference in score decline over two-year follow-up period between Aβ positive and negative group (p = 0.03). Linear mixed model analyses also showed that the Aβ x time interaction effect was significant only for Composite 1 (p = 0.025). Based on the results, Composite 1 was chosen as the final cognitive composite for preclinical Alzheimer's disease (CPAD). Conclusions: CPAD can be used to assess subtle cognitive decline of preclinical AD in clinical research settings, especially in Korean older adults. It also may be used for monitoring progression or treatment benefits in clinical practices. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Association of apolipoprotein E in peripheral blood and in vivo Alzheimer’s disease pathologies in nondemented older adults

Author

Byun, Min Soo, primary, Yi, Dahyun, additional, Ahn, Hyejin, additional, Kim, Min Jung, additional, Jung, Joon Hyung, additional, Jung, Gi Jung, additional, Lee, Jun‐Young, additional, Kim, Yu Kyeong, additional, Lee, Yun‐Sang, additional, Kang, Koung Mi, additional, Sohn, Chul‐Ho, additional, and Lee, Dong Young, additional

Published
2022
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50. Additional file 1 of Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology

Author

Kim, Taewon, Yi, Dahyun, Byun, Min Soo, Ahn, Hyejin, Jung, Joon Hyung, Kong, Nayeong, Kim, Min Jung, Jung, Gijung, Lee, Jun-Young, Lee, Yun-Sang, Kim, Yu Kyeong, and Lee, Dong Young

Abstract

Additional file 1: Supplementary Table 1. Interaction effect of global WMH volume and global Aβ on inferior tau deposition. Supplementary Table 2. Interaction effect of BP marker and global Aβ on inferior temporal tau deposition with additional adjustment with global WMH volume.

Published
2023
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