96 results on '"Yeun J."'
Search Results
2. Lymphoepithelial carcinoma of the salivary glands
- Author
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Kim, Yeun J., Hong, Hyun S., Jeong, Sun H., Lee, Eun H., and Jung, Min J.
- Published
- 2017
- Full Text
- View/download PDF
3. Evaluation of subsurface utility engineering for highway projects: Benefit–cost analysis
- Author
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Jung, Yeun J.
- Published
- 2012
- Full Text
- View/download PDF
4. Utility impact rating with subsurface utility engineering in project development
- Author
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Jung, Yeun J.
- Subjects
Industrial project management -- Research ,Project management -- Research ,Engineering and manufacturing industries ,Research - Abstract
A lack of reliable information regarding the locations of underground utilities can not only result in property damage, construction delays, design changes, claims, injuries, and even deaths but can also cause traffic delays, local business disruptions, environmental problems, and utility service breakdowns in highway projects. The subsurface utility engineering (SUE) is an engineering process designed to reduce the potential of underground utility conflicts at the planning phase. The SUE uses new and existing technologies to identify, characterize, and map accurately the underground utilities with three major activities: designation, location, and data management. In this study, a decision-support tool called the SUE utility impact rating form, which refers to utility complexity at the construction site, has been developed to determine which projects should include SUE and the appropriate levels of SUE investigation to be used. In addition, case studies with benefit-cost ratio have been performed to verify the form. Key words: subsurface utility engineering, decision-support tool, utility impact rating. Lors de projets autoroutiers, le manque d'information fiable concernant les emplacements des services publics souterrains peut non seulement causer des dommages a la propriete, des delais de construction, des changements a la conception, des reclamations, des blessures et meme des deces, mais peut egalement causer des retards dans l'ecoulement du trafic, des perturbations aux commerces locaux, des problemes environnementaux et des pannes des services publics. L'ingenierie des services publics souterrains (<>) est un processus d'ingenierie concru pour reduire le potentiel de conflits des services publics souterrains lors de la phase de planification. La SUE utilise des technologies nouvelles and existantes pour identifier, caracteriser et cartographier precisement les services publics souterrains par trois activites principales : la designation, l'emplacement et la gestion des donnees. Dans la presente etude, un outil d'aide a la decision, appele la formule de classement des impacts de la SUE sur les services publics, a ete developpe en se basant sur le classement des impacts sur les services publics, ce dernier se referant a la complexite des services publics au site de construction, afin de determiner quels projets devraient inclure la SUE et les niveaux appropries d'etude SUE a etre utilises. De plus, des etudes de cas avec un rapport couts-avantages ont ete realisees afin de verifier la formule de classement. Mots-cles : ingenierie des services publics souterrains, outil d'aide a la decision, classement des impacts sur les services publics. [Traduit par la Redaction], Introduction Nearly 20 million miles of underground pipelines, cables, and wires in the U.S. have been built since World War II and designed for lifetimes of 20-50 years (Sterling 2000). [...]
- Published
- 2009
- Full Text
- View/download PDF
5. 51.24 YOUTH SOCIAL MEDIA USE BEFORE AND DURING THE COVID-19 PANDEMIC
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Guest, Christina, Ogata, Michael, Feldmeier, Michael L., Lim, Yeun J., Nabieva, Guiouzel, Szeftel, Roxy, and Pataki, Caroly
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Psychiatry and Mental health ,Developmental and Educational Psychology ,Article - Published
- 2020
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6. Identification of human astrovirus infections from stool samples with diarrhea in Korea
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Kang, Y.-H., Park, Y.-K., Ahn, J.-B., Yeun, J.-D., and Jee, Y.-M.
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- 2002
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7. 51.16 SOCIAL MEDIA USE AND IMPACT ON YOUTH DURING THE COVID-19 PANDEMIC: A NOVEL ELECTRONIC QUESTIONNAIRE TO ENGAGE YOUTH ABOUT SOCIAL MEDIA USE
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Ogata, Michael, primary, Guest, Christina, additional, Feldmeier, Michael L., additional, Lim, Yeun J., additional, Nabieva, Guiouzel, additional, Pataki, Caroly, additional, and Szeftel, Roxy, additional
- Published
- 2020
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- View/download PDF
8. 39.4 ELECTRONIC AND SOCIAL MEDIA USE IN YOUTH AND PLATFORMS FOR CLINICAL ENGAGEMENT
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Lim, Yeun J., primary, Guest, Christina, additional, Ogata, Michael, additional, Feldmeier, Michael L., additional, Nabieva, Guiouzel, additional, Szeftel, Roxy, additional, and Pataki, Caroly, additional
- Published
- 2020
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- View/download PDF
9. 39.4 ELECTRONIC AND SOCIAL MEDIA USE IN YOUTH AND PLATFORMS FOR CLINICAL ENGAGEMENT
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Yeun J. Lim, Christina Guest, Michael Ogata, Michael L. Feldmeier, Guiouzel Nabieva, Roxy Szeftel, and Caroly Pataki
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Psychiatry and Mental health ,Developmental and Educational Psychology - Published
- 2020
10. Extended daily dialysis vs. continuous hemodialysis for ICU patients with acute renal failure: A two-year single center report
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KUMAR, V. A., YEUN, J. Y., DEPNER, T. A., and DON, B. R.
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- 2004
11. Computed tomography angiography with pulmonary artery thrombus burden and right-to-left ventricular diameter ratio after pulmonary embolism
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Samuel Z. Goldhaber, Yeun J Lim, Gregory Piazza, Kenneth Ouriel, and Richard L. Ouriel
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medicine.medical_specialty ,Computed Tomography Angiography ,Intraclass correlation ,Heart Ventricles ,medicine.medical_treatment ,Arterial Occlusive Diseases ,Pulmonary Artery ,030204 cardiovascular system & hematology ,Severity of Illness Index ,behavioral disciplines and activities ,030218 nuclear medicine & medical imaging ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,medicine.artery ,Fibrinolysis ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Computed tomography angiography ,Observer Variation ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Thrombosis ,General Medicine ,medicine.disease ,Pulmonary embolism ,Predictive value of tests ,Pulmonary artery ,Surgery ,Radiology ,Pulmonary Embolism ,Cardiology and Cardiovascular Medicine ,business ,Right-to-left - Abstract
Purpose Computed tomography angiography is used for quantifying the significance of pulmonary embolism, but its reliability has not been well defined. Methods The study cohort comprised 10 patients randomly selected from a 150-patient prospective trial of ultrasound-facilitated fibrinolysis for acute pulmonary embolism. Four reviewers independently evaluated the right-to-left ventricular diameter ratios using the standard multiplanar reformatted technique and a simplified (axial) method, and thrombus burden with the standard modified Miller score and a new, refined Miller scoring system. Results The intraclass correlation coefficient for intra-observer variability was .949 and .970 for the multiplanar reformatted and axial methods for estimating right-to-left ventricular ratios, respectively. Inter-observer agreement was high and similar for the two methods, with intraclass correlation coefficient of .969 and .976. The modified Miller score had good intra-observer agreement (intraclass correlation coefficient .820) and was similar to the refined Miller method (intraclass correlation coefficient .883) for estimating thrombus burden. Inter-observer agreement was also comparable between the techniques, with intraclass correlation coefficient of .829 and .914 for the modified Miller and refined Miller methods. Conclusions The reliability of computed tomography angiography for pulmonary embolism was excellent for the axial and multiplanar reformatted methods for quantifying the right-to-left ventricular ratio and for the modified Miller and refined Miller scores for quantifying of pulmonary artery thrombus burden.
- Published
- 2016
12. Transdifferentiation-inducing HCCR-1 oncogene
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Kim Jin, Park Yong G, Kim Dong W, Jeun Shin S, Chung Yeun J, Kim Tae E, Kim Yong W, Hur Soo Y, Lee Youn S, Shin Seung M, Kim SangHee, Yoo JinAh, Kim Hyun K, Ha Seon-Ah, Shin Soon Y, Lee Young H, and Kim Jin W
- Subjects
Cytology ,QH573-671 - Abstract
Abstract Background Cell transdifferentiation is characterized by loss of some phenotypes along with acquisition of new phenotypes in differentiated cells. The differentiated state of a given cell is not irreversible. It depends on the up- and downregulation exerted by specific molecules. Results We report here that HCCR-1, previously shown to play an oncogenic role in human cancers, induces epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) in human and mouse, respectively. The stem cell factor receptor CD117/c-Kit was induced in this transdifferentiated (EMT) sarcoma tissues. This MET occurring in HCCR-1 transfected cells is reminiscent of the transdifferentiation process during nephrogenesis. Indeed, expression of HCCR-1 was observed during the embryonic development of the kidney. This suggests that HCCR-1 might be involved in the transdifferentiation process of cancer stem cell. Conclusions Therefore, we propose that HCCR-1 may be a regulatory factor that stimulates morphogenesis of epithelia or mesenchyme during neoplastic transformation.
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- 2010
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13. Underground Utility Locating Technologies for Condition Assessment and Renewal Engineering of Water Pipeline Infrastructure Systems
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Sunil K. Sinha, Berk Uslu, and Yeun J. Jung
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Engineering ,business.industry ,Mechanical Engineering ,Reliability (computer networking) ,0211 other engineering and technologies ,020101 civil engineering ,02 engineering and technology ,Subsurface utility engineering ,Asset (computer security) ,Condition assessment ,Pipeline (software) ,Construction engineering ,0201 civil engineering ,Transport engineering ,Asset management ,business ,021101 geological & geomatics engineering ,Civil and Structural Engineering - Abstract
Underground asset locating practices use new and existing technologies to accurately identify, characterize, and map buried utilities through the integration of professional utility records, visual site inspection, geophysical techniques, survey, and utility exposure. The efficient use of locating practices allows effective condition assessment and renewal engineering applications, which, in turn, improves asset management practices for water utilities. Utility engineers, managers, and practitioners need to be familiar with all locating technologies (working principles, capabilities, and limitations) to have an effective selection of the appropriate technologies for every scenario. There are capabilities and limitations of all existing underground utility locating technologies that are used by water utilities. This paper provides the factors affecting the reliability of underground pipe locating surveys and presents an overview of the capabilities and limitations of the locating technologies to gu...
- Published
- 2016
14. Evaluation of subsurface utility engineering for highway projects: Benefit–cost analysis
- Author
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Yeun J. Jung
- Subjects
Program evaluation ,Engineering ,Road construction ,Operations research ,Factor cost ,Cost–benefit analysis ,business.industry ,media_common.quotation_subject ,Building and Construction ,Subsurface utility engineering ,Geotechnical Engineering and Engineering Geology ,Transport engineering ,Project planning ,Quality (business) ,business ,media_common - Abstract
Accurate location of buried utility infrastructures is a vital issue for utility owners, utility managers and engineers, designers, and contractors that perform new installations, repairs, and maintenance on highway projects. Unreliable information on underground utilities can result in undesirable consequences such as property damage, claims, and other social and environmental problems. Subsurface utility engineering (SUE) is becoming a significant method for reducing the potential for underground utility conflicts at the project planning phase. SUE accurately identifies, characterizes, and maps underground utilities through four quality levels. This study presents a SUE benefit–cost analysis (BCA) to encourage a better understanding of SUE and the use of SUE. Eleven main benefit factors and two cost factors are identified and estimated on twenty-two SUE projects and eight non-SUE projects from Pennsylvania Department of Transportation (PennDOT) districts. In addition, this study reveals the relationship between benefit–cost ratio and complexity levels of buried utilities.
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- 2012
15. Utility impact rating with subsurface utility engineering in project development
- Author
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Yeun J. JungY.J. Jung
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Design modification ,Engineering ,Service (systems architecture) ,Operations research ,business.industry ,Data management ,Subsurface utility engineering ,Phase (combat) ,Risk analysis (engineering) ,Project management ,business ,Engineering design process ,General Environmental Science ,Civil and Structural Engineering - Abstract
A lack of reliable information regarding the locations of underground utilities can not only result in property damage, construction delays, design changes, claims, injuries, and even deaths but can also cause traffic delays, local business disruptions, environmental problems, and utility service breakdowns in highway projects. The subsurface utility engineering (SUE) is an engineering process designed to reduce the potential of underground utility conflicts at the planning phase. The SUE uses new and existing technologies to identify, characterize, and map accurately the underground utilities with three major activities: designation, location, and data management. In this study, a decision-support tool called the SUE utility impact rating form, which refers to utility complexity at the construction site, has been developed to determine which projects should include SUE and the appropriate levels of SUE investigation to be used. In addition, case studies with benefit–cost ratio have been performed to verify the form.
- Published
- 2009
16. Evaluation of Trenchless Technology Methods for Municipal Infrastructure System
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Sunil K. Sinha and Yeun J. Jung
- Subjects
Transport engineering ,Indirect costs ,Engineering ,Upgrade ,Underground pipeline ,business.industry ,Cost analysis ,Capital cost ,Landscaping ,business ,Productivity ,Civil and Structural Engineering ,Trenchless technology - Abstract
The deterioration of municipal underground infrastructure systems and a growing demand for utility services have increased the necessity for more efficient installation, inspection, repair, rehabilitation, and replacement of underground utilities. With conventional open-cut construction methods, direct costs are greatly increased by the need to restore ground surfaces such as sidewalks, pavement, landscaping, and brick paving. Furthermore, taking social and environmental factors into account, open-cut methods have adverse impacts on the community, business, and commuters due to undesirable pollution and traffic disruptions. Trenchless technologies that are used to repair, upgrade, replace, or install underground infrastructure systems with minimum surface disruption offer a viable alternative to existing open-cut methods. The objective of this paper is to describe a methodology for quantitatively assessing and comparing direct, social, and environmental costs associated with municipal underground pipeline construction. It is suggested that decision makers consider combining these costs with direct capital costs so that the best alternative is selected, which in certain cases can make trenchless technology the most economical alternative. Moreover, productivity, workers' safety, and structural issues have shown that trenchless technology is a more efficient method for underground infrastructure systems.
- Published
- 2007
17. Underground Utility Locating Technologies for Condition Assessment and Renewal Engineering of Water Pipeline Infrastructure Systems
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Uslu, Berk, primary, Jung, Yeun J., additional, and Sinha, Sunil K., additional
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- 2016
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18. Lymphoepithelial carcinoma of the salivary glands
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Yeun J. Kim, Eun Hye Lee, Hyun Sook Hong, Sun H. Jeong, and Min J. Jung
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,salivary gland ,Malignancy ,Lymphoepithelial carcinoma ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Major Salivary Gland ,Humans ,Medicine ,Clinical Case Report ,Aged ,Salivary gland ,business.industry ,Carcinoma ,computed tomography ,ultrasonography ,030206 dentistry ,General Medicine ,Salivary Gland Neoplasms ,medicine.disease ,Right parotid gland ,medicine.anatomical_structure ,Homogeneous ,030220 oncology & carcinogenesis ,Female ,lymphoepithelial carcinoma ,Differential diagnosis ,Tomography, X-Ray Computed ,business ,Research Article - Abstract
Rationale: Lymphoepithelial carcinoma (LEC) is a rare malignancy with the histopathological feature of undifferentiated carcinoma and an intermixed reactive lymphoplasmacytic infiltration. Although clinically significant because of its malignant nature, it is difficult to make a differential diagnosis by preoperative imaging. Here, we report 3 cases of primary LEC arising in the major salivary glands, which showed unusual imaging features unlike other malignant tumors. Patient concerns: Our first case is a 44-year-old man with LEC in the right parotid gland, the second case is a 71-year-old woman with LEC in the right submandibular gland, and the third case is a 35-year-old woman with LEC in the right parotid gland. All of the patients presented with a palpable mass of variable duration. Diagnoses: Computed tomography (CT) scans revealed a relatively well-defined, slightly hyperattenuated exophytic solid mass that had homogeneous well-enhanced regions. Ultrasonography (US) in the first 2 cases showed well-defined, hypoechoic solid masses with posterior enhancement. The CT findings seem to be benign tumors, but US features are compatible with highly cellular and hypervascular tumors. Interventions: The resection of the involved salivary gland with postoperative radiation therapy was performed. Outcomes: There was no evidence of recurrence or metastasis after 5 years in all 3 patients. Lessons: Understanding these unusual imaging findings may be helpful in detecting LEC, and may also help clinicians provide adequate management to patients, such as surgery with adjuvant radiotherapy, because of its malignant entity.
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- 2017
19. Xenobiotic Response in Humanized Double Transgenic Mice Expressing Tetracycline-Controlled Transactivator and Human CYP1B1
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Yun Y. Shin, Bum J. Kim, In S. Jang, Dae Youn Hwang, Kab Ryong Chae, Jin H. Hwang, Dong Hoon Shin, Yong K. Kim, Chae H. Lim, Jung S. Cho, Yeun J. Kim, and Jun S. Goo
- Subjects
Male ,Genetically modified mouse ,Transgene ,CYP1B1 ,Biophysics ,Mice, Transgenic ,Biology ,Kidney ,Biochemistry ,Xenobiotics ,Mice ,Transactivation ,chemistry.chemical_compound ,Cytochrome P-450 Enzyme System ,In vivo ,medicine ,Animals ,Humans ,Transgenes ,Intestinal Mucosa ,Promoter Regions, Genetic ,Lung ,Molecular Biology ,Doxycycline ,Myocardium ,Brain ,Cytochrome P450 ,Tetracycline ,Immunohistochemistry ,Molecular biology ,Mice, Inbred C57BL ,Gene Expression Regulation ,Liver ,chemistry ,Mice, Inbred DBA ,Organ Specificity ,Cytochrome P-450 CYP1B1 ,Microsomes, Liver ,biology.protein ,Female ,Aryl Hydrocarbon Hydroxylases ,medicine.drug ,Toxicant - Abstract
The cytochrome P450 enzymes (P450s or CYPs) are a superfamily of hemeproteins that catalyze the monooxygenation of a wide range of endobiotic and xenobiotic substrates. A typical strategy in toxicological research and testing involves applying a toxicant at high doses for a short period to homogeneous animals under controlled conditions. However, the conditions of this approach have very little in common with actual human exposure. Transgenic (Tg) mice carrying human genes encoding a drug-metabolizing enzyme (CYP) offer a solution to many of the difficulties in the evaluation of chemical toxicity. It has been demonstrated that the expression of human CYP transgenes under the control of mammalian-inducible promoters exhibits relatively poor fold increases after induction. In this study, we used the tetracycline-regulated (tet) promoter system to increase the expression of the human CYP1B1 (hCYP1B1) gene in the tissues of transgenic mice. By mating two lineages of transgenic mice, double transgenic (dTg) mice expressing both tTA and hCYP1B1 genes under the control of the tet promoter were successfully produced, into which the two transgenes were introduced in an embryo. The expression pattern of tTA-driven hCYP1B1 transgene featured a fold induction of more than 3 to 12 in the brain, heart, and lung and 2- to 4-fold induction in the liver, kidney, and intestine upon doxycycline removal. Immunohistochemical staining with hCYP1B1 antibody was also increased by the removal of doxycycline. In addition, the activities of CYP liver microsomes in the dTg mice without doxycycline showed an increase compared to that in the dTg mice treated with doxycycline. The level of activities correspond to the levels of human CYP1B1 protein expression in the Tg mice (-dox) that was increased by 2-fold induction as compared to that of the dTg mice with doxycycline. Thus, overproduction in Tg can be purified and the activity of purified human CYP1B1 can be characterized by alterations to the coding sequence in order to solve the physiological function of this enzyme in a humanized in vivo system. It is also possible to examine the activity of purified human CYP1B1 using several environmental toxicants such as procarcinogens.
- Published
- 2001
20. Computed tomography angiography with pulmonary artery thrombus burden and right-to-left ventricular diameter ratio after pulmonary embolism
- Author
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Ouriel, Kenneth, primary, Ouriel, Richard L, additional, Lim, Yeun J, additional, Piazza, Gregory, additional, and Goldhaber, Samuel Z, additional
- Published
- 2016
- Full Text
- View/download PDF
21. The intracellular trafficking and distribution of VEGF165
- Author
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Maria Luisa Guzman-Hernandez, Jozsef Zoltan Kiss, Gael Potter, Tamas Balla, and Yeun J Kim
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Chemistry ,Genetics ,Biophysics ,Distribution (pharmacology) ,Molecular Biology ,Biochemistry ,Intracellular ,Biotechnology - Published
- 2012
22. Transdifferentiation-inducing HCCR-1 oncogene
- Author
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Soo Y. Hur, Seung Min Shin, Tae E. Kim, Soon Young Shin, Jinah Yoo, Hyun Kee Kim, Yeun J Chung, Yong G. Park, Youn Soo Lee, Shin Soo Jeun, Sanghee Kim, Kim Jin, Yong W. Kim, Seon-Ah Ha, Jin W. Kim, Dong Wook Kim, and Young Han Lee
- Subjects
Cellular differentiation ,Mesenchyme ,Mice, Nude ,Stem cell factor ,Biology ,Kidney ,Mice ,Cancer stem cell ,Proto-Oncogene Proteins ,medicine ,Animals ,Humans ,Neoplastic transformation ,Transgenes ,lcsh:QH573-671 ,Cloning, Molecular ,Mice, Inbred BALB C ,lcsh:Cytology ,Transdifferentiation ,Gene Expression Regulation, Developmental ,Kidney metabolism ,Cell Biology ,Cell biology ,Proto-Oncogene Proteins c-kit ,Cell Transformation, Neoplastic ,medicine.anatomical_structure ,Cell Transdifferentiation ,NIH 3T3 Cells ,Neoplasm Transplantation ,Research Article - Abstract
Background Cell transdifferentiation is characterized by loss of some phenotypes along with acquisition of new phenotypes in differentiated cells. The differentiated state of a given cell is not irreversible. It depends on the up- and downregulation exerted by specific molecules. Results We report here that HCCR-1, previously shown to play an oncogenic role in human cancers, induces epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) in human and mouse, respectively. The stem cell factor receptor CD117/c-Kit was induced in this transdifferentiated (EMT) sarcoma tissues. This MET occurring in HCCR-1 transfected cells is reminiscent of the transdifferentiation process during nephrogenesis. Indeed, expression of HCCR-1 was observed during the embryonic development of the kidney. This suggests that HCCR-1 might be involved in the transdifferentiation process of cancer stem cell. Conclusions Therefore, we propose that HCCR-1 may be a regulatory factor that stimulates morphogenesis of epithelia or mesenchyme during neoplastic transformation.
- Published
- 2010
23. Research and Development Program for the Third National Geographic Information System Project in Korea: Korean Land Spatialization Program
- Author
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Yeun J. Jung, Byung-Guk Kim, and Hoon-Sung Choi
- Subjects
Government ,Economic growth ,Geographic information system ,Geospatial analysis ,business.industry ,media_common.quotation_subject ,Control (management) ,Business model ,computer.software_genre ,Spatialization ,Private equity fund ,Geography ,Service (economics) ,business ,computer ,media_common - Abstract
Under control of the Ministry of Land, Transport and Maritime Affairs (MLTMA) and Korea Institute of Construction & Transportation Technology Evaluation and Planning (KICTTEP), Inha University, Incheon, Korea, has conducted Korean Land Spatialization Program (KLSP). KLSP aims at providing not only geospatial information technology, but also service and business models based on the technology for the future ubiquitous society. KLSP is one of the Value Creator (VC) 10 projects, which was planned by the Korean Government, for the future. The first program of KLSP, from 2006 to 2012, initiated with $132 million (US dollars) of National Fund and $42 million of Private Fund. The second program will be conducted from 2012 to 2016. This paper introduces KLSP and attracts international collaboration to this great program.
- Published
- 2008
24. Subsurface Utility Engineering for Highway Construction
- Author
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Yeun J. Jung, H. Randolph Thomas, Sunil K. Sinha, and Mian C. Wang
- Subjects
Engineering ,Change order ,Operations research ,business.industry ,Damages ,Subsurface utility engineering ,Environmental economics ,business ,Productivity ,Cost savings - Abstract
Utility Engineering (SUE) reduces unnecessary utility relocations, unexpected damages of existing utilities, miss-locations of utilities, change orders and claims, personnel injuries, negative factors for productivity, social and environmental damages, and other problems related to utilities through accurate underground information. The benefits are combined with subsequent savings in time and cost for whole projects. Considerable previous research has shown that using SUE can save money on projects involving underground utilities. This paper describes a benefit-cost analysis (BCA) that quantifies the cost savings of SUE with projects developed in Pennsylvania. This study uses both SUE projects and non-SUE projects to quantify the cost savings of SUE on highway projects. This study focuses on a detailed benefit-cost analysis performed on twenty-two SUE projects and eight non-SUE projects.
- Published
- 2008
25. Computed tomography angiography with pulmonary artery thrombus burden and right-to-left ventricular diameter ratio after pulmonary embolism.
- Author
-
Ouriel, Kenneth, Ouriel, Richard L., Lim, Yeun J., Piazza, Gregory, and Goldhaber, Samuel Z.
- Abstract
Purpose Computed tomography angiography is used for quantifying the significance of pulmonary embolism, but its reliability has not been well defined. Methods The study cohort comprised 10 patients randomly selected from a 150-patient prospective trial of ultrasound-facilitated fibrinolysis for acute pulmonary embolism. Four reviewers independently evaluated the right-to-left ventricular diameter ratios using the standard multiplanar reformatted technique and a simplified (axial) method, and thrombus burden with the standard modified Miller score and a new, refined Miller scoring system. Results The intraclass correlation coefficient for intra-observer variability was .949 and .970 for the multiplanar reformatted and axial methods for estimating right-to-left ventricular ratios, respectively. Inter-observer agreement was high and similar for the two methods, with intraclass correlation coefficient of .969 and .976. The modified Miller score had good intra-observer agreement (intraclass correlation coefficient .820) and was similar to the refined Miller method (intraclass correlation coefficient .883) for estimating thrombus burden. Inter-observer agreement was also comparable between the techniques, with intraclass correlation coefficient of .829 and .914 for the modified Miller and refined Miller methods. Conclusions The reliability of computed tomography angiography for pulmonary embolism was excellent for the axial and multiplanar reformatted methods for quantifying the right-to-left ventricular ratio and for the modified Miller and refined Miller scores for quantifying of pulmonary artery thrombus burden. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
26. Research and Development Program for the Third National Geographic Information System Project in Korea: Korean Land Spatialization Program
- Author
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Kim, Byung-Guk, primary, Choi, Hoon-Sung, additional, and Jung, Yeun J., additional
- Full Text
- View/download PDF
27. Long-term ouabain administration produces hypertension in rats
- Author
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YUAN CM, HAMLYN JM, CHEN S, BOHEN E, YEUN J, HADDY FJ, PAMNANI MB, MANUNTA , PAOLO, Yuan, Cm, Manunta, Paolo, Hamlyn, Jm, Chen, S, Bohen, E, Yeun, J, Haddy, Fj, and Pamnani, Mb
- Published
- 1993
28. Death Adder Envenoming Causes Neurotoxicity Not Reversed by Antivenom - Australian Snakebite Project (ASP-16).
- Author
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White J., Jus S., William V., McCoubrie D., Dawson A., Littl M., Gaul A., Pascui O., Ryan N., Mill K., Miller P., Close B., Curran S., Gunj N., Dowsett R., Ghen T., Johnston C.I., O'Leary M.A., Brown S.G.A., Currie B., Whitaker R., Isbister G.K., Nagree Y., Ker F., Greene S., Taylor M., Macrokanis C., Wilke G., Coulson A., Barnes C., Bonni R., Whitake R., Halkidis L., Isbiste G., Downe M., Whyte I., Tankel A., Greenberg R., Webb M., Ellis R., Spai D., Irelan G., Gan M., Porges K., Bitmea D., Tay K., Miller M., Baile P., Vlad I., Gavaghan C., Holdgate A., McGregor K., Fraser T., Graudins A., Garre P., Ward D., Buckle N., Chan B., Pag C., Parkin A., Mead H., Thompso P., Treston G., Alfred S., Gray T., Yeun J., Brow S., White J., Jus S., William V., McCoubrie D., Dawson A., Littl M., Gaul A., Pascui O., Ryan N., Mill K., Miller P., Close B., Curran S., Gunj N., Dowsett R., Ghen T., Johnston C.I., O'Leary M.A., Brown S.G.A., Currie B., Whitaker R., Isbister G.K., Nagree Y., Ker F., Greene S., Taylor M., Macrokanis C., Wilke G., Coulson A., Barnes C., Bonni R., Whitake R., Halkidis L., Isbiste G., Downe M., Whyte I., Tankel A., Greenberg R., Webb M., Ellis R., Spai D., Irelan G., Gan M., Porges K., Bitmea D., Tay K., Miller M., Baile P., Vlad I., Gavaghan C., Holdgate A., McGregor K., Fraser T., Graudins A., Garre P., Ward D., Buckle N., Chan B., Pag C., Parkin A., Mead H., Thompso P., Treston G., Alfred S., Gray T., Yeun J., and Brow S.
- Abstract
Background: Death adders (Acanthophis spp) are found in Australia, Papua New Guinea and parts of eastern Indonesia. This study aimed to investigate the clinical syndrome of death adder envenoming and response to antivenom treatment. Methodology/Principal Findings: Definite death adder bites were recruited from the Australian Snakebite Project (ASP) as defined by expert identification or detection of death adder venom in blood. Clinical effects and laboratory results were collected prospectively, including the time course of neurotoxicity and response to treatment. Enzyme immunoassay was used to measure venom concentrations. Twenty nine patients had definite death adder bites; median age 45 yr (5-74 yr); 25 were male. Envenoming occurred in 14 patients. Two further patients had allergic reactions without envenoming, both snake handlers with previous death adder bites. Of 14 envenomed patients, 12 developed neurotoxicity characterised by ptosis (12), diplopia (9), bulbar weakness (7), intercostal muscle weakness (2) and limb weakness (2). Intubation and mechanical ventilation were required for two patients for 17 and 83 hours. The median time to onset of neurotoxicity was 4 hours (0.5-15.5 hr). One patient bitten by a northern death adder developed myotoxicity and one patient only developed systemic symptoms without neurotoxicity. No patient developed venom induced consumption coagulopathy. Antivenom was administered to 13 patients, all receiving one vial initially. The median time for resolution of neurotoxicity post-antivenom was 21 hours (5-168). The median peak venom concentration in 13 envenomed patients with blood samples was 22 ng/mL (4.4-245 ng/mL). In eight patients where post-antivenom bloods were available, no venom was detected after one vial of antivenom. Conclusions/Significance: Death adder envenoming is characterised by neurotoxicity, which is mild in most cases. One vial of death adder antivenom was sufficient to bind all circulating venom. The persis
- Published
- 2012
29. The intracellular trafficking and distribution of VEGF165
- Author
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Guzman-Hernandez, Maria Luisa, primary, Potter, Gael, additional, Kim, Yeun J, additional, Kiss, Jozsef Z, additional, and Balla, Tamas, additional
- Published
- 2012
- Full Text
- View/download PDF
30. Transdifferentiation-inducing HCCR-1 oncogene
- Author
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Ha, Seon-Ah, primary, Kim, Hyun K, additional, Yoo, JinAh, additional, Kim, SangHee, additional, Shin, Seung M, additional, Lee, Youn S, additional, Hur, Soo Y, additional, Kim, Yong W, additional, Kim, Tae E, additional, Chung, Yeun J, additional, Jeun, Shin S, additional, Kim, Dong W, additional, Park, Yong G, additional, Kim, Jin, additional, Shin, Soon Y, additional, Lee, Young H, additional, and Kim, Jin W, additional
- Published
- 2010
- Full Text
- View/download PDF
31. Subsurface Utility Engineering for Highway Construction
- Author
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Sinha, Sunil K., primary, Jung, Yeun J., additional, Thomas, H. Randolph, additional, and Wang, Mian C., additional
- Published
- 2008
- Full Text
- View/download PDF
32. Evaluation of Trenchless Technology Methods for Municipal Infrastructure System
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Jung, Yeun J., primary and Sinha, Sunil K., additional
- Published
- 2007
- Full Text
- View/download PDF
33. Xenobiotic Response in Humanized Double Transgenic Mice Expressing Tetracycline-Controlled Transactivator and Human CYP1B1
- Author
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Hwang, Dae Y., primary, Chae, Kab R., additional, Shin, Dong H., additional, Hwang, Jin H., additional, Lim, Chae H., additional, Kim, Yeun J., additional, Kim, Bum J., additional, Goo, Jun S., additional, Shin, Yun Y., additional, Jang, In S., additional, Cho, Jung S., additional, and Kim, Yong K., additional
- Published
- 2001
- Full Text
- View/download PDF
34. SOLUTE KINETICS DURING EXTENDED DAILY HEMODIALYSIS IN THE INTENSIVE CARE UNIT (ICU)
- Author
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Depner, T A, primary, Craig, M, additional, Hu, K T, additional, Kumar, V, additional, Tarne, P, additional, and Yeun, J Y, additional
- Published
- 1999
- Full Text
- View/download PDF
35. Long-term ouabain administration produces hypertension in rats.
- Author
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Yuan, C M, primary, Manunta, P, additional, Hamlyn, J M, additional, Chen, S, additional, Bohen, E, additional, Yeun, J, additional, Haddy, F J, additional, and Pamnani, M B, additional
- Published
- 1993
- Full Text
- View/download PDF
36. Trandifferentiation-inducing HCCR-1 oncogene.
- Author
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Seon-Ah Ha, Hyun K. Kim, JinAh Yoo, SangHee Kim, Shin, Seung M., Lee, Youn S., Hur, Soo Y., Kim, Yong W., Kim, Tae E., Chung, Yeun J., Jeun, Shin S., Kim, Dong W., Park, Yong G., Jin Kim, Shin, Soon Y., Lee, Young H., and Kim, Jin W.
- Subjects
PHENOTYPES ,ONCOGENIC viruses ,CANCER ,STEM cells ,SARCOMA ,MORPHOGENESIS - Abstract
Background: Cell transdifferentiation is characterized by loss of some phenotypes along with acquisition of new phenotypes in differentiated cells. The differentiated state of a given cell is not irreversible. It depends on the up- and downregulation exerted by specific molecules. Results: We report here that HCCR-1, previously shown to play an oncogenic role in human cancers, induces epithelialto- mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) in human and mouse, respectively. The stem cell factor receptor CD117/c-Kit was induced in this transdifferentiated (EMT) sarcoma tissues. This MET occurring in HCCR-1 transfected cells is reminiscent of the transdifferentiation process during nephrogenesis. Indeed, expression of HCCR-1 was observed during the embryonic development of the kidney. This suggests that HCCR-1 might be involved in the transdifferentiation process of cancer stem cell. Conclusions: Therefore, we propose that HCCR-1 may be a regulatory factor that stimulates morphogenesis of epithelia or mesenchyme during neoplastic transformation. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
37. C-reactive protein, oxidative stress, homocysteine, and troponin as inflammatory and metabolic predictors of atherosclerosis in ESRD.
- Author
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Yeun, Jane Y., Kaysen, George A., Yeun, J Y, and Kaysen, G A
- Published
- 2000
- Full Text
- View/download PDF
38. Chronic calcium pyrophosphate crystal deposition disease arthropathy associated with hypomagnesemia.
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Erickson, Alan R., Yeun, Jane Y., Enzenauer, Raymond J., Erickson, A R, Yeun, J Y, and Enzenauer, R J
- Published
- 1997
- Full Text
- View/download PDF
39. Computer Simulated Development of a Command to Line-of-Sight Missile Using On-Off Control.
- Author
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NAVAL POSTGRADUATE SCHOOL MONTEREY CA, Yeun,J Y, NAVAL POSTGRADUATE SCHOOL MONTEREY CA, and Yeun,J Y
- Abstract
An on-off control provides a minimum time response for missile control. For application in missile control systems, it is wasteful of control effort (due to chatter) to use a ideal relay. Hence it is necessary to modify the ideal relay into a saturating linear control. The result was almost the same to that of using the ideal relay. (Author)
- Published
- 1983
40. Clinical utility of C-reactive protein measurements.
- Author
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Yeun, Jane Y. and Yeun, J Y
- Subjects
- *
C-reactive protein , *HEMODIALYSIS patients , *CLINICAL chemistry , *DISEASES - Abstract
Evaluates the diagnostic utility of measuring C-reactive protein levels in hemodialysis patients. Disease conditions which may cause C-reactive protein levels to rise; Challenges to the measurement of C-reactive protein levels in hemodialysis patients; Clinical significance of making diagnostic use of C-reactive protein measurements in hemodialysis patients.
- Published
- 2000
- Full Text
- View/download PDF
41. A 120 MFLOPS CMOS floating-point processor.
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Chai, P., Chuk, T., Fong, Y.H., Hu, L., Ng, K., Prabhu, J., Quek, A., Samuels, A., and Yeun, J.
- Published
- 1991
- Full Text
- View/download PDF
42. Long-Lasting, Transparent Antibacterial Shield: A Durable, Broad-Spectrum Anti-Bacterial, Non-Cytotoxic, Transparent Nanocoating for Extended Wear Contact Lenses.
- Author
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Park N, Moon CE, Song Y, Yu Sun S, Kwon JM, Yoon S, Park S, Jeong B, Yeun J, Hardie JM, Lee JK, Lee KG, Ji YW, and Im SG
- Abstract
The increasing incidence of serious bacterial keratitis, a sight-threatening condition often exacerbated by inadequate contact lens (CLs) care, highlights the need for innovative protective technology. This study introduces a long-lasting antibacterial, non-cytotoxic, transparent nanocoating for CLs via a solvent-free polymer deposition method, aiming to prevent bacterial keratitis. The nanocoating comprises stacked polymer films, with poly(dimethylaminomethyl styrene-co-ethylene glycol dimethacrylate) (pDE) as a biocompatible, antibacterial layer atop poly(2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane) (pV4D4) as an adhesion-promoting layer. The pD6E1-grafted (g)-pV4D4 film shows non-cytotoxicity toward two human cell lines and antibacterial activity of >99% against four bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic-resistant bacteria and Pseudomonas aeruginosa, which causes ocular diseases. Additionally, the film demonstrates long-lasting antibacterial activity greater than 96% against MRSA for 9 weeks in phosphate-buffered saline. To the best knowledge, this duration represents the longest reported long-term stability with less than 5% decay of antibacterial performance among contact-killing antibacterial coatings. The film exhibits exceptional mechanical durability, retaining its antibacterial activity even after 15 washing cycles. The pD6E1-g-pV4D4-coated CL maintains full optical transmittance compared to that of pristine CL. It is expected that the unprecedentedly prolonged antibacterial performance of the coating will significantly alleviate the risk of infection for long-term CL users., (© 2024 Wiley‐VCH GmbH.)
- Published
- 2024
- Full Text
- View/download PDF
43. Long-Term Culture of Human Pluripotent Stem Cells in Xeno-Free Condition Using Functional Polymer Films.
- Author
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Cho Y, Lee H, Jeong W, Jung KB, Lee SY, Park S, Yeun J, Kwon O, Son JG, Lee TG, Son MY, and Im SG
- Subjects
- Humans, Human Embryonic Stem Cells cytology, Human Embryonic Stem Cells metabolism, Laminin chemistry, Laminin pharmacology, Cell Proliferation drug effects, Cell Adhesion drug effects, Proteoglycans chemistry, Proteoglycans pharmacology, Cell Line, Collagen chemistry, Cell Differentiation drug effects, Drug Combinations, Cell Culture Techniques methods, Polymers chemistry, Pluripotent Stem Cells cytology, Induced Pluripotent Stem Cells cytology, Induced Pluripotent Stem Cells metabolism
- Abstract
Human pluripotent stem cells (hPSCs), encompassing human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), hold immense potential in regenerative medicine, offering new opportunities for personalized cell therapies. However, their clinical translation is hindered by the inevitable reliance on xenogeneic components in culture environments. This study addresses this challenge by engineering a fully synthetic, xeno-free culture substrate, whose surface composition is tailored systematically for xeno-free culture of hPSCs. A functional polymer surface, pGC2 (poly(glycidyl methacrylate-grafting-guanidine-co-carboxylic acrylate)), offers excellent cell-adhesive properties as well as non-cytotoxicity, enabling robust hESCs and hiPSCs growth while presenting cost-competitiveness and scalability over Matrigel. This investigation includes comprehensive evaluations of pGC2 across diverse experimental conditions, demonstrating its wide adaptability with various pluripotent stem cell lines, culture media, and substrates. Crucially, pGC2 supports long-term hESCs and hiPSCs expansion, up to ten passages without compromising their stemness and pluripotency. Notably, this study is the first to confirm an identical proteomic profile after ten passages of xeno-free cultivation of hiPSCs on a polymeric substrate compared to Matrigel. The innovative substrate bridges the gap between laboratory research and clinical translation, offering a new promising avenue for advancing stem cell-based therapies., (© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.)
- Published
- 2024
- Full Text
- View/download PDF
44. Hydrophobic surface induced pro-metastatic cancer cells for in vitro extravasation models.
- Author
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Lee M, Kim S, Lee SY, Son JG, Park J, Park S, Yeun J, Lee TG, Im SG, and Jeon JS
- Abstract
In vitro vascularized cancer models utilizing microfluidics have emerged as a promising tool for mechanism study and drug screening. However, the lack of consideration and preparation methods for cancer cellular sources that are capable of adequately replicating the metastatic features of circulating tumor cells contributed to low relevancy with in vivo experimental results. Here, we show that the properties of cancer cellular sources have a considerable impact on the validity of the in vitro metastasis model. Notably, with a hydrophobic surface, we can create highly metastatic spheroids equipped with aggressive invasion, endothelium adhesion capabilities, and activated metabolic features. Combining these metastatic spheroids with the well-constructed microfluidic-based extravasation model, we validate that these metastatic spheroids exhibited a distinct extravasation response to epidermal growth factor (EGF) and normal human lung fibroblasts compared to the 2D cultured cancer cells, which is consistent with the previously reported results of in vivo experiments. Furthermore, the applicability of the developed model as a therapeutic screening platform for cancer extravasation is validated through profiling and inhibition of cytokines. We believe this model incorporating hydrophobic surface-cultured 3D cancer cells provides reliable experimental data in a clear and concise manner, bridging the gap between the conventional in vitro models and in vivo experiments., Competing Interests: None., (© 2023 The Authors.)
- Published
- 2024
- Full Text
- View/download PDF
45. The role of mucosal barriers in human gut health.
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Seo K, Seo J, Yeun J, Choi H, Kim YI, and Chang SY
- Subjects
- Epithelial Cells metabolism, Gastrointestinal Microbiome, Humans, Intestinal Mucosa metabolism
- Abstract
The intestinal mucosa is continuously exposed to a large number of commensal or pathogenic microbiota and foreign food antigens. The intestinal epithelium forms a dynamic physicochemical barrier to maintain immune homeostasis. To efficiently absorb nutrients from food, the epithelium in the small intestine has thin, permeable layers spread over a vast surface area. Epithelial cells are renewed from the crypt toward the villi, accompanying epithelial cell death and shedding, to control bacterial colonization. Tight junction and adherens junction proteins provide epithelial cell-cell integrity. Microbial signals are recognized by epithelial cells via toll-like receptors. Environmental signals from short-chain fatty acids derived from commensal microbiota metabolites, aryl hydrocarbon receptors, and hypoxia-induced factors fortify gut barrier function. Here we summarize recent findings regarding various environmental factors for gut barrier function. Further, we discuss the role of gut barriers in the pathogenesis of human intestinal disease and the challenges of therapeutic strategies targeting gut barrier restoration.
- Published
- 2021
- Full Text
- View/download PDF
46. Development, implementation, and results of the ASN in-training examination for fellows.
- Author
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Rosner MH, Berns JS, Parker M, Tolwani A, Bailey J, DiGiovanni S, Lederer E, Norby S, Plumb TJ, Qian Q, Yeun J, Hawley JL, and Owens S
- Subjects
- Attitude of Health Personnel, Certification, Curriculum, Educational Measurement, Health Knowledge, Attitudes, Practice, Humans, Internet, Problem-Based Learning, Program Development, Program Evaluation, Societies, Medical, United States, Education, Medical, Graduate, Fellowships and Scholarships, Nephrology education
- Abstract
The American Society of Nephrology and the fellowship training program directors in conjunction with the National Board of Medical Examiners developed a comprehensive assessment of medical knowledge for nephrology fellows in-training. This in-training examination (ITE) consisted of 150 multiple-choice items covering 11 broad content areas in a blueprint similar to the American Board of Internal Medicine certifying examination for nephrology. Questions consisted of case vignettes to simulate real-life clinical experience. The first examination was given in April 2009 to 682 fellows and six training program directors. Examinees felt that the examination was well structured and relevant to their training experience Longitudinal performance on the examination will be helpful in allowing training programs to utilize results from content areas in identifying deficits in medical knowledge as well as assessing the results of any curriculum changes.
- Published
- 2010
- Full Text
- View/download PDF
47. Initial therapy for uncomplicated hypertension: insights from the alphabetic maze of recent studies.
- Author
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Stewart JR and Yeun JY
- Subjects
- Adrenergic beta-Antagonists therapeutic use, Clinical Trials as Topic, Confounding Factors, Epidemiologic, Diuretics therapeutic use, Humans, Meta-Analysis as Topic, Practice Guidelines as Topic, Antihypertensive Agents therapeutic use, Hypertension drug therapy
- Abstract
Some hypertension treatment guidelines published in the late 1990's recommended that diuretics and betha-blockers be used as 1st line drugs for treating uncomplicated hypertension, reserving new antihypertensive drugs for special indications. This recommendation is predicated on the fact that large trials showing cardiovascular protection with antihypertensive drugs used betha-blockers and diuretics. Other guidelines suggested all antihypertensives are equal and that drug selection should be individualized. These disparate guidelines arise from the controversy over "are all antihypertensives created equal?" Since these guidelines, many large hypertension trials have been conducted. This paper will review the recent hypertension trials, the meta-analyses of some of these trials, highlight some of the flaws inherent in the trials that making interpretation difficult, and finally outline a rationale approach to initial treatment of the uncomplicated hypertensive patient. It will provide a rationale for 1) using diuretic and not beth-blocker as the 1st line agent in treating uncomplicated hypertension, 2) switching to an angiotensin converting enzyme inhibitor or angiotensin receptor blocker should side effects occur on diuretic, 3) reserving calcium channel blocker, betha-blocker, and alpha-blocker for 2nd or 3(rd) line therapy, 4) employing a diuretic in combination with any other antihypertensive class, and 5) considering use of lower doses of 2 or more antihypertensives to limit side effects while optimizing blood pressure control. If the incidence of de novo diabetes is indeed higher with diuretics and cost-analysis confirm long-term savings with using a more expensive but less diabetogenic drug to treat hypertension, then the recommendation may shift to using an antihypertensive that acts on the renin-angiotensin axis.
- Published
- 2003
48. Daily dialysis in North America: evidence for a bright future.
- Author
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Kumar VA, Yeun JY, and Kaysen GA
- Subjects
- Humans, North America, Renal Dialysis adverse effects, Renal Dialysis economics, Renal Dialysis trends, Time Factors, Treatment Outcome, Renal Dialysis methods
- Published
- 2003
- Full Text
- View/download PDF
49. Initial antihypertensive therapy. What are the current drugs of choice?
- Author
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Yeun JY
- Subjects
- Adrenergic beta-Antagonists therapeutic use, Adult, Aged, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Calcium Channel Blockers therapeutic use, Confounding Factors, Epidemiologic, Diuretics therapeutic use, Female, Humans, Hypertension complications, Male, Middle Aged, Randomized Controlled Trials as Topic, Treatment Outcome, Antihypertensive Agents therapeutic use, Cardiovascular Diseases etiology, Cardiovascular Diseases mortality, Cardiovascular Diseases prevention & control, Hypertension drug therapy
- Abstract
The goal of antihypertensive treatment, in addition to lowering blood pressure, is to reduce the risk of cardiovascular events. Until recently, however, only conventional treatment with diuretics and beta-blockers had been studied in terms of cardiovascular end points. In this article, Dr Yeun reviews the results of recent trials comparing these agents with other classes of antihypertensive drugs. She examines the confounding elements in the trials, provides an interpretation of study results, and suggests a practical approach to initial treatment of uncomplicated hypertension.
- Published
- 2001
- Full Text
- View/download PDF
50. Extended daily dialysis: A new approach to renal replacement for acute renal failure in the intensive care unit.
- Author
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Kumar VA, Craig M, Depner TA, and Yeun JY
- Subjects
- Anticoagulants therapeutic use, Female, Hemodiafiltration, Hemofiltration adverse effects, Humans, Hypotension etiology, Intensive Care Units, Male, Middle Aged, Renal Dialysis adverse effects, Acute Kidney Injury therapy, Renal Dialysis methods
- Abstract
Continuous venovenous hemofiltration (CVVH) is an effective form of renal replacement therapy for acute renal failure (ARF) that offers greater hemodynamic stability and better volume control than conventional hemodialysis in the critically ill, hypotensive patient. However, the application of CVVH in the intensive care unit (ICU) has several disadvantages, including intensive nursing requirements, continuous anticoagulation, patient immobility, and expense. We describe a new approach to the treatment of ARF in the ICU, which we have termed extended daily dialysis (EDD). In this study, EDD was compared with CVVH in 42 patients: 25 patients were treated with EDD for a total of 367 treatment days, and 17 patients were treated with CVVH for a total of 113 days. Median treatment time per day was 7.5 hours for EDD (range, 6 to 8 hours, 25th to 75th percentile) versus 19.5 hours for CVVH (range, 13.4 to 24 hours; P < 0.001). Mean arterial blood pressures (MAPs) did not differ significantly for patients treated with EDD when measured predialysis (median MAP, 70 versus 67 mm Hg for CVVH; P = 0.078), midway through daily treatment (70 versus 68 mm Hg for CVVH; P = 0.083), or at the end of treatment (71 versus 69 mm Hg for CVVH; P = 0.07). Net daily ultrafiltration was similar for the two treatment modalities (EDD, median, 3,000 mL/d; range, 1,763 to 4,445 mL/d; CVVH, 3,028 mL/d; range, 1,785 to 4,707 mL/d; P = 0.514). Anticoagulation requirements were significantly less for patients treated with EDD (median dose of heparin, 4,000 U/d; range, 0 to 5,800 U/d versus 21,100 U/d; range, 8,825 to 31,275 U/d for patients treated with CVVH; P < 0.001). We found that EDD eliminated the need for constant supervision of the dialysis machine by a subspecialty dialysis nurse, allowing one nurse to manage more than one treatment. Overall, EDD was well tolerated by the majority of patients, offered many of the same benefits provided by CVVH, and was technically easier to perform.
- Published
- 2000
- Full Text
- View/download PDF
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