3 results on '"Yerly, S. (Sabine)"'
Number of results to display per page
Search Results
2. Impact of the M184V/I Mutation on the Efficacy of Abacavir/Lamivudine/Dolutegravir Therapy in HIV Treatment-Experienced Patients
- Author
-
Olearo, F. (Flaminia), Nguyen, H. (Huyen), Bonnet, F. (Fabrice), Yerly, S. (Sabine), Wandeler, G. (Gilles), Stoeckle, M. (Marcel), Cavassini, M. (Matthias), Scherrer, A. (Alexandra), Costagiola, D. (Dominique), Schmid, P. (Patrick), Günthard, H.F., Bernasconi, E. (Enos), Boeni, J. (Jürg), D'Arminio Monforte, A. (Antonella), Zazzi, M. (Maurizio), Rossetti, B. (Barbara), Neau, D. (Didier), Bellecave, P. (Pantxika), Rijnders, B.J.A. (Bart), Reiss, P. (Peter), Wit, F.W.N.M. (Ferdinand), Kouyos, R.D. (Roger), Calmy, A. (Alexandra), Olearo, F. (Flaminia), Nguyen, H. (Huyen), Bonnet, F. (Fabrice), Yerly, S. (Sabine), Wandeler, G. (Gilles), Stoeckle, M. (Marcel), Cavassini, M. (Matthias), Scherrer, A. (Alexandra), Costagiola, D. (Dominique), Schmid, P. (Patrick), Günthard, H.F., Bernasconi, E. (Enos), Boeni, J. (Jürg), D'Arminio Monforte, A. (Antonella), Zazzi, M. (Maurizio), Rossetti, B. (Barbara), Neau, D. (Didier), Bellecave, P. (Pantxika), Rijnders, B.J.A. (Bart), Reiss, P. (Peter), Wit, F.W.N.M. (Ferdinand), Kouyos, R.D. (Roger), and Calmy, A. (Alexandra)
- Abstract
Objective: The impact of the M184V/I mutation on the virological failure (VF) rate in HIV-positive patients with suppressed viremia switching to an abacavir/lamivudine/dolutegravir regimen has been poorly evaluated. Method: This is an observational study from 5 European HIV cohorts among treatment-experienced adults with ≤50 copies/mL of HIV-1 RNA who switched to abacavir/lamivudine/dolutegravir. Primary outcome was the time to first VF (2 consecutive HIV-1 RNA >50 copies/mL or single HIV-1 RNA >50 copies/mL accompanied by change in antiretroviral therapy [ART]). We also analyzed a composite outcome considering the presence of VF and/or virological blips. We report also the results of an inverse probability weighting analysis on a restricted population with a prior history of VF on any ART regimen to calculate statistics standardized to the disparate sampling population. Results: We included 1626 patients (median follow-up, 288.5 days; interquartile range, 154-441). Patients with a genotypically documented M184V/I mutation (n = 137) had a lower CD4 nadir and a longer history of antiviral treatment. The incidence of VF was 29.8 cases (11.2-79.4) per 1000 person-years in those with a previously documented M184V/I, and 13.6 cases (8.4-21.8) in patients without documented M184V/I. Propensity score weighting in a restricted population (n = 580) showed that M184V/I was not associated with VF or the composite endpoint (hazard ratio [HR], 1.27; 95% confidence interval [CI], 0.35-4.59 and HR 1.66; 95% CI, 0.81-3.43, respectively). Conclusions: In ART-experienced patients switching to an abacavir/lamivudine/dolutegravir treatment, we observed few VFs and found no evidence for an impact of previously-acquired M184V/I mutation on this outcome. Additional analyses are required to demonstrate whether these findings will remain robust during a longer follow-up.
- Published
- 2019
- Full Text
- View/download PDF
3. The global spread of HIV-1 subtype B epidemic
- Author
-
Magiorkinis, G. (Gkikas), Angelis, K. (Konstantinos), Mamais, I. (Ioannis), Katzourakis, A. (Aris), Hatzakis, A. (Angelos), Albert, J. (Jan), Lawyer, G. (Glenn), Hamouda, O. (Osamah), Struck, D. (Daniel), Vercauteren, J. (Jurgen), Wensing, A. (Amj), Alexiev, I. (Ivailo), Åsjö, B. (Birgitta), Balotta, C. (Claudia), Gomes, P. (Perpétua), Camacho, R.J. (Ricardo Jorge), Coughlan, S. (Suzie), Griskevicius, A. (Algirdas), Grossman, Z. (Zehava), Horban, A. (Anders), Kostrikis, L.G. (Leondios), Lepej, S.J. (Snjezana J.), Liitsola, K. (Kirsi), Linka, M. (Marek), Nielsen, C., Otelea, D. (Dan), Paredes, R. (Roger), Poljak, M. (Mario), Puchhammer-Stöckl, E. (Elisabeth), Schmit, J.C., Sonnerborg, A. (Anders), Stanekova, D. (Danica), Stanojevic, M. (Maja), Stylianou, D.C. (Dora C.), Boucher, C.A.B. (Charles), Nikolopoulos, G. (Georgios), Vasylyeva, T. (Tetyana), Friedman, S.R. (Samuel R.), Vijver, D.A.M.C. (David) van de, Angarano, G. (Guiseppe), Chaix, M.L. (Marie Laure), Luca, A. (Andrea) de, Korn, K. (Klaus), Loveday, C. (Clive), Soriano, V. (Virtudes), Yerly, S. (Sabine), Zazzi, M., Vandamme, A.M. (Anne Mieke), Paraskevis, D. (Dimitrios), Magiorkinis, G. (Gkikas), Angelis, K. (Konstantinos), Mamais, I. (Ioannis), Katzourakis, A. (Aris), Hatzakis, A. (Angelos), Albert, J. (Jan), Lawyer, G. (Glenn), Hamouda, O. (Osamah), Struck, D. (Daniel), Vercauteren, J. (Jurgen), Wensing, A. (Amj), Alexiev, I. (Ivailo), Åsjö, B. (Birgitta), Balotta, C. (Claudia), Gomes, P. (Perpétua), Camacho, R.J. (Ricardo Jorge), Coughlan, S. (Suzie), Griskevicius, A. (Algirdas), Grossman, Z. (Zehava), Horban, A. (Anders), Kostrikis, L.G. (Leondios), Lepej, S.J. (Snjezana J.), Liitsola, K. (Kirsi), Linka, M. (Marek), Nielsen, C., Otelea, D. (Dan), Paredes, R. (Roger), Poljak, M. (Mario), Puchhammer-Stöckl, E. (Elisabeth), Schmit, J.C., Sonnerborg, A. (Anders), Stanekova, D. (Danica), Stanojevic, M. (Maja), Stylianou, D.C. (Dora C.), Boucher, C.A.B. (Charles), Nikolopoulos, G. (Georgios), Vasylyeva, T. (Tetyana), Friedman, S.R. (Samuel R.), Vijver, D.A.M.C. (David) van de, Angarano, G. (Guiseppe), Chaix, M.L. (Marie Laure), Luca, A. (Andrea) de, Korn, K. (Klaus), Loveday, C. (Clive), Soriano, V. (Virtudes), Yerly, S. (Sabine), Zazzi, M., Vandamme, A.M. (Anne Mieke), and Paraskevis, D. (Dimitrios)
- Abstract
Human immunodeficiency virus type 1 (HIV-1) was discovered in the early 1980s when the virus had already established a pandemic. For at least three decades the epidemic in the Western World has been dominated by subtype B infections, as part of a sub-epidemic that traveled from Africa through Haiti to United States. However, the pattern of the subsequent spread still remains poorly understood. Here we analyze a large dataset of globally representative HIV-1 subtype B strains to map their spread around the world over the last 50. years and describe significant spread patterns. We show that subtype B travelled from North America to Western Europe in different occasions, while Central/Eastern Europe remained isolated for the most part of the early epidemic. Looking with more detail in European countries we see that the United Kingdom, France and Switzerland exchanged viral isolates with non-European countries than with European ones. The observed pattern is likely to mirror geopolitical landmarks in the post-World War II era, namely the rise and the fall of the Iron Curtain and the European colonialism. In conclusion, HIV-1 spread through specific migration routes which are consistent with geopolitical factors that affected human activities during the last 50. years, such as migration, tourism and trade. Our findings support the argument that epidemic control policies should be global and incorporate political and socioeconomic factors. . . .
- Published
- 2016
- Full Text
- View/download PDF
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.