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528 results on '"Yerebakan, Can"'

9. Hybrid palliation versus nonhybrid management for a multi-institutional cohort of infants with critical left heart obstruction

Author

Argo, Madison B., Barron, David J., Bondarenko, Igor, Eckhauser, Aaron, Gruber, Peter J., Lambert, Linda M., Paramananthan, Tharini, Rahman, Maha, Winlaw, David S., Yerebakan, Can, Alsoufi, Bahaaldin, DeCampli, William M., Honjo, Osami, Kirklin, James K., Prospero, Carol, Ramakrishnan, Karthik, St. Louis, James D., Turek, Joseph W., O'Brien, James E., Jr, Pizarro, Christian, Anagnostopoulos, Petros V., Blackstone, Eugene H., Jacobs, Marshall L., Jegatheeswaran, Anusha, Karamlou, Tara, Stephens, Elizabeth H., Polimenakos, Anastasios C., Haw, Marcus P., and McCrindle, Brian W.

Published
2023
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10. Norwood operation versus comprehensive stage II after bilateral pulmonary artery banding palliation for infants with critical left heart obstruction

Author

Argo, Madison B., Barron, David J., Eghtesady, Pirooz, Alsoufi, Bahaaldin, Honjo, Osami, Yerebakan, Can, DeCampli, William M., Jacobs, Jeffrey P., Carrillo, Sergio A., Jegatheeswaran, Anusha, Karamlou, Tara, Paramananthan, Tharini, Rahman, Maha, Lambert, Linda M., Nelson, Jennifer, Caldarone, Christopher A., Husain, S. Adil, Galantowicz, Mark E., Ramakrishnan, Karthik, Kirklin, James K., Turek, Joseph W., Mannie, Chelsea, Blackstone, Eugene H., Mitchell, Michael E., and McCrindle, Brian W.

Published
2023
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17. Connecting transcriptomics with computational modeling to reveal developmental adaptations in pediatric human atrial tissue.

Author

Salameh, Shatha, Guerrelli, Devon, Miller, Jacob A., Desai, Manan, Moise, Nicolae, Yerebakan, Can, Bruce, Alisa, Sinha, Pranava, d'Udekem, Yves, Weinberg, Seth H., and Posnack, Nikki Gillum

Subjects
ACTION potentials, GENE expression, CARDIAC patients, CHILD patients, CONGENITAL heart disease
Abstract

Nearly 1% of babies are born with congenital heart disease—many of whom will require heart surgery within the first few years of life. A detailed understanding of cardiac maturation can help to expand our knowledge on cardiac diseases that develop during gestation, identify age-appropriate drug therapies, and inform clinical care decisions related to surgical repair and postoperative management. Yet, to date, our knowledge of the temporal changes that cardiomyocytes undergo during postnatal development is limited. In this study, we collected right atrial tissue samples from pediatric patients (n = 117) undergoing heart surgery. Patients were stratified into five age groups. We measured age-dependent adaptations in cardiac gene expression and used computational modeling to simulate action potential and calcium transients. Enrichment of differentially expressed genes revealed age-dependent changes in several key biological processes (e.g., cell cycle, structural organization), cardiac ion channels, and calcium handling genes. Gene-associated changes in ionic currents exhibited age-dependent trends, with changes in calcium handling (INCX) and repolarization (IK1) most strongly associated with an age-dependent decrease in the action potential plateau potential and increase in triangulation, respectively. We observed a shift in repolarization reserve, with lower IKr expression in younger patients, a finding potentially tied to an increased amplitude of IKs that could be triggered by elevated sympathetic activation in pediatric patients. Collectively, this study provides valuable insights into age-dependent changes in human cardiac gene expression and electrophysiology, shedding light on molecular mechanisms underlying cardiac maturation and function throughout development. NEW & NOTEWORTHY: To date, our knowledge of the temporal changes that cardiomyocytes undergo during postnatal development is limited. In this study, we demonstrate age-dependent adaptations in the gene expression profile of >100 atrial tissue samples collected from congenital heart disease patients. We coupled transcriptomics datasets with computational modeling to simulate action potentials and calcium transients for different pediatric age groups. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Abstract 10158: Initial Bilateral Pulmonary Artery Banding for Infants With Critical Left Heart Obstruction: A Multi-Institutional Analysis of Outcomes

Author

Argo, Madison B, Barron, David J, Eghtesady, Pirooz, Alsoufi, Bahaaldin, Carrillo, Sergio A, Honjo, Osami, Husain, Adil, Jacobs, Jeffrey P, Jegatheeswaran, Anusha, Kirklin, James K, Lambert, Linda M, Paramananthan, Tharini, Rahman, Maha, Ramakrishnan, Karthik, Yerebakan, Can, Galantowicz, Mark E, Caldarone, Christopher A, Decampli, William M, Karamlou, Tara, Nelson, Jennifer, Romano, Jennifer C, Turek, Joseph W, and McCrindle, Brian W

Published
2022
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29. Pediatric Tele-Critical Care: Initial Experience with a Continuous Surveillance Model Aiming to Prevent Cardiac Arrest in Children with Critical Heart Disease.

Author

Lopez Magallon, Alejandro, Saenz, Lucas, Mehta, Rittal, Chacón, Maria Angelica, Martinez Ransanz, Santiago, Swink, Kellie, Berris, Menchee, Hanabergh, Sofia, Yerebakan, Can, Wessel, David, and Munoz, Ricardo

Subjects
CARDIAC intensive care, CONGENITAL heart disease, CORONARY care units, ELECTRONIC health records, THERAPEUTICS
Abstract

Introduction: Despite advances in treatment of children with critical heart disease, cardiac arrest (CA) remains a common occurrence. We provided virtual support to bedside teams (BTs) from a tele-critical care (TCC) unit in a pediatric cardiac intensive care unit (CICU) and focused on early detection of concerning trends (CT) and avoidance of CA. Virtual surveillance workflows included a review of remote monitoring, video feed from patient room cameras, medical records, and artificial intelligence tools. We present our initial experience with a focus on critical communications (CCs) to BTs. Methods: A retrospective, descriptive review of TCC activities was conducted from January 2019 to December 2022, involving electronic databases and electronic medical records of patients in the CICU, including related CCs to BTs, responses from BTs, and related CA. Results: We conducted 18,171 TCC activities, including 2,678 non-CCs and 248 CCs. Over time, there was a significant increase in the proportion of CCs related with CT (p = 0.002), respiratory concerns (<0.001), and abnormalities in cardiac rhythm (p = 0.04). Among a sample of 244 CCs, subsequent interventions by BTs resulted in adjustment of medical treatment (127), respiratory support (68), surgery or intervention (19), cardiac rhythm control (17), imaging study (14), early resuscitation (9), and others (10). Conclusions: CCs from a TCC unit in a pediatric CICU changed over time with an increased focus on CT and resulted in early interventions, potentially contributing to avoiding CA. This model of care in pediatric cardiac critical care has the potential to improve patient safety. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Excellent Survival With a Focus on Pulmonary Artery Reinterventions After the Arterial Switch Operation

Author

Selcuk, Arif, Ozturk, Mahmut, Tongut, Aybala, Sterzbecher, Vanessa, Park, In Hye, Mehta, Rittal, Desai, Manan, Yerebakan, Can, and d’Udekem, Yves

Abstract

Background:We sought to evaluate the outcomes in patients who underwent the arterial switch operation (ASO) over a 20-year period at a single institution. Methods:The current study is a retrospective review of 180 consecutive patients who underwent the ASO for biventricular surgical correction of dextro-transposition of the great arteries (d-TGA) between 2002 and 2022. Results:Among 180 patients, 121 had TGA-intact ventricular septum, 47 had TGA-ventricular septal defect and 12 had Taussig-Bing Anomaly (TBA). The median follow-up time was 6.7 years (interquartile range: 3.9-8.7 years). There were five early (2.8%) and one late (0.6%) mortality. Survival was 96.6% at one year and beyond. Reoperations were performed in 31 patients (17%). Taussig Bing Anomaly was found to increase the risk of reoperation by 17 times (P< .0001). A total of 37 (21%) patients underwent 53 reinterventions (14 surgical procedures, 39 catheter interventions) specifically addressing pulmonary artery (PA) stenosis. Freedom from PA reintervention was 97%, 87%, 70%, and 55% at 1, 5, 10, and 15 years, respectively. By bivariable analysis, TBA (P= .003, odds ratio [OR]: 6.4, 95% confidence interval [CI]: 1.9-21.7), mild PA stenosis at discharge (P≤ .001, OR: 6.1, 95% CI: 2.7-13.6), and moderate or severe PA stenosis at discharge (P≤ .001, OR: 12.7, 95% CI: 5-32.2) were identified as predictors of reintervention on PA. In the last follow-up of 174 survivors, 24 patients (14%) had moderate or greater PA stenosis, two (1%) had moderate neoaortic valve regurgitation, and 168 were New York Heart Association status I. Conclusions:Our results demonstrated excellent survival and functional status following the ASO for d-TGA; however, patients remain subject to frequent reinterventions especially on the pulmonary arteries.

Published
2024
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42. The Technique of Bilateral Pulmonary Artery Banding in High-Risk Patients With Hypoplastic Left Heart Syndrome.

Author

Yerebakan, Can, Tongut, Aybala, Ozturk, Mahmut, Ceneri, Nicolle M., and d'Udekem, Yves

Abstract

The management of high-risk neonates with hypoplastic left heart syndrome or its variants remains a tremendous surgical and medical challenge for our specialty. The hybrid strategy has been shown to improve outcomes in high-risk patients. This article illustrates the specific technical details of bilateral branch pulmonary artery banding for such high-risk patients. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Tiny pacemakers for tiny babies

Author

Berul, Charles I., primary, Dasgupta, Soham, additional, LeGras, Marc D., additional, Peer, S. Murfad, additional, Alsoufi, Bahaaldin, additional, Sherwin, Elizabeth D., additional, Desai, Manan, additional, Yerebakan, Can, additional, and Johnsrude, Christopher, additional

Published
2023
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49. The Children’s National Hospital Outcomes Registry: a plea for a benchmarking tool that provides longitudinal outcomes for patients and families

Author

Venna, Alyssia, Haverty, Mitchell, Kreutzer, Janet, Mehta, Rittal, Fetch, Alix, Tongut, Aybala, Desai, Manan, Yerebakan, Can, and d’Udekem, Yves

Abstract

AbstractSurgical advancements in paediatric cardiovascular surgery have led to improved survival rates for those patients with the most complex CHDs leading to greater numbers of patients who are living well into adulthood. Despite this new era of long-term survival, our current reporting systems continue to focus largely on using short-term postoperative outcomes as the criteria to both rate and rank hospitals. Using such limited criteria to rate and rank hospitals may mislead the intended audiences: patients and families. The goal of this article is to describe the creation of a local benchmarking report which aims to retrospectively review long-term outcomes from our single centre. This report is updated annually and published on our cardiac surgery webpage in an effort to be as transparent as possible for our patient and family communities.

Published
2024
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