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23 results on '"Yeramilli, Venkata"'

22. Development of CD27+ marginal zone B cells requires GALT.

Author

Yeramilli, Venkata A. and Knight, Katherine L.

Abstract

In species other than mouse, little is known about the origin and development of marginal zone (MZ) B cells. Using cross-reactive antibodies, we identified and characterized splenic MZ B cells in rabbits as CD27+CD23−. In rabbits in which organized gut-associated lymphoid tissue (GALT) was surgically removed at birth, we found only CD23+ follicular (FO) B cells and almost no CD27+ MZ B cells in the spleen, indicating that GALT is required for the development of splenic MZ B cells. These findings lead us to suggest that commensal microbiota contribute to the development of MZ B cells. [ABSTRACT FROM AUTHOR]

Published
2013
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23. Development of CD27+ marginal zone B cells requires GALT.

Author

Yeramilli VA and Knight KL

Subjects
Animals, Animals, Newborn, Cell Differentiation, Lymphoid Tissue surgery, Metagenome immunology, Mice, Rabbits, Receptors, IgE metabolism, Tumor Necrosis Factor Receptor Superfamily, Member 7 metabolism, B-Lymphocytes immunology, Intestines immunology, Spleen immunology
Abstract

In species other than mouse, little is known about the origin and development of marginal zone (MZ) B cells. Using cross-reactive antibodies, we identified and characterized splenic MZ B cells in rabbits as CD27(+) CD23(-). In rabbits in which organized gut-associated lymphoid tissue (GALT) was surgically removed at birth, we found only CD23(+) follicular (FO) B cells and almost no CD27(+) MZ B cells in the spleen, indicating that GALT is required for the development of splenic MZ B cells. These findings lead us to suggest that commensal microbiota contribute to the development of MZ B cells., (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2013
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