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2 results on '"Yeo Gyu Yun"'

1. The Expression of Tumor-Associated Macrophages in Papillary Thyroid Carcinoma

Author

Seunghwan Kim, Sun Wook Cho, Hye Sook Min, Kang Min Kim, Gye Jeong Yeom, Eun Young Kim, Kyu Eun Lee, Yeo Gyu Yun, Do Joon Park, and Young Joo Park

Subjects
Tumor-associated macrophages, Thyroid cancer, papillary, Tumor size, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

BackgroundTumor-associated macrophages (TAMs) play a tumorigenic role related to advanced staging and poor prognosis in many human cancers including thyroid cancers. Yet, a functional role of TAMs in papillary thyroid carcinoma (PTC) has not been established. The aim of this study was to investigate TAM expression in human PTC with lymph node (LN) metastasis.MethodsThirty-six patients who underwent surgery after being diagnosed with PTC with LN metastasis were included. Primary tumor tissues were immunohistochemically stained with an anti-CD68 antibody and clinical characteristics according to TAM density were evaluated.ResultsThe TAM densities (CD68+ cells) varied from 5% to 70%, in all tumor areas, while few cells were stained in adjacent normal tissues. TAMs were identified as CD68+ cells with thin, elongated cytoplasmic extensions that formed a canopy structure over tumor cells. Comparing clinicopathologic characteristics between tumors with low (

Published
2013
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2. The Expression of Tumor-Associated Macrophages in Papillary Thyroid Carcinoma

Author

Hye Sook Min, Kang Min Kim, Sun Wook Cho, Seunghwan Kim, Young Joo Park, Gye Jeong Yeom, Eun Young Kim, Do Joon Park, Kyu Eun Lee, and Yeo Gyu Yun

Subjects
Poor prognosis, Pathology, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Metastasis, Thyroid carcinoma, Endocrinology, stomatognathic system, medicine, skin and connective tissue diseases, Lymph node, lcsh:RC648-665, biology, business.industry, CD68, Tumor-associated macrophages, Thyroid, Thyroid cancer, papillary, Tumor size, medicine.disease, Primary tumor, medicine.anatomical_structure, biology.protein, Original Article, Antibody, business, hormones, hormone substitutes, and hormone antagonists
Abstract

Background: Tumor-associated macrophages (TAMs) play a tumorigenic role related to advanced staging and poor prognosis in many human cancers including thyroid cancers. Yet, a functional role of TAMs in papillary thyroid carcinoma (PTC) has not been established. The aim of this study was to investigate TAM expression in human PTC with lymph node (LN) metastasis. Methods: Thirty-six patients who underwent surgery after being diagnosed with PTC with LN metastasis were included. Primary tumor tissues were immunohistochemically stained with an anti-CD68 antibody and clinical characteristics according to TAM density were evaluated. Results: The TAM densities (CD68 + cells) varied from 5% to 70%, in all tumor areas, while few cells were stained in adjacent normal tissues. TAMs were identified as CD68 + cells with thin, elongated cytoplasmic extensions that formed a canopy structure over tumor cells. Comparing clinicopathologic characteristics between tumors with low (

Published
2013

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