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1. Cohort profile : Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO)

Author

the S-PRESTO Study Group, Loo, Evelyn Xiu Ling, Soh, Shu-E, Loy, See Ling, Ng, Sharon, Tint, Mya Thway, Chan, Shiao-Yng, Huang, Jonathan Yinhao, Yap, Fabian, Tan, Kok Hian, Chern, Bernard S. M., Tan, Heng Hao, Meaney, Michael J., Karnani, Neerja, Godfrey, Keith M., Lee, Yung Seng, Chan, Jerry Kok Yen, Gluckman, Peter D., Chong, Yap-Seng, Shek, Lynette Pei-Chi, Eriksson, Johan G., Chia, Airu, Fogel, Anna Magdalena, Goh, Anne Eng Neo, Chu, Anne Hin Yee, Rifkin-Graboi, Anne, Qiu, Anqi, Lee, Bee Wah, Cheon, Bobby Kyungbeom, Vaz, Candida, Henry, Christiani Jeyakumar, Forde, Ciaran Gerard, Chi, Claudia, Koh, Dawn Xin Ping, Phua, Desiree Y., Loh, Doris Ngiuk Lan, Quah, Elaine Phaik Ling, Tham, Elizabeth Huiwen, Law, Evelyn Chung Ning, Magkos, Faidon, Mueller-Riemenschneider, Falk, Yeo, George Seow Heong, Yong, Hannah Ee Juen, Chen, Helen Yu, Pan, Hong, van Bever, Hugo P S, Tan, Hui Min, Aris, Izzuddin Bin Mohd, Tay, Jeannie, Xu, Jia, Yoong, Joanne Su-Yin, Eriksson, Johan Gunnar, Choo, Jonathan Tze Liang, Bernard, Jonathan Y., Lai, Jun Shi, Tan, Karen Mei Ling, Kwek, Kenneth Yung Chiang, McCrickerd, Keri, Narasimhan, Kothandaraman, Chong, Kok Wee, Lee, Kuan Jin, Chen, Li, Ling, Lieng Hsi, Chen, Ling-Wei, Daniel, Lourdes Mary, Fortier, Marielle V., Chong, Mary Foong-Fong, Chua, Mei Chien, Leow, Melvin Khee-Shing, Kee, Michelle Zhi Ling, Gong, Min, Michael, Navin, Lek, Ngee, Teoh, Oon Hoe, Mishra, Priti, Li, Queenie Ling Jun, Velan, Sambasivam Sendhil, Ang, Seng Bin, Cai, Shirong, Goh, Si Hui, Lim, Sok Bee, Tsotsi, Stella, Hsu, Stephen Chin-Ying, Toh, Sue-Anne Ee Shiow, Sadananthan, Suresh Anand, Tan, Teng Hong, Yew, Tong Wei, Gupta, Varsha, Rajadurai, Victor Samuel, Han, Wee Meng, Pang, Wei Wei, Yuan, Wen Lun, Zhu, Yanan, Cheung, Yin Bun, Chan, Yiong Huak, and Cheng, Zai Ru

Published
2021

7. Maternal plasma phosphatidylcholine polyunsaturated fatty acids during pregnancy and offspring growth and adiposity

Author

Bernard, Jonathan Y., Tint, Mya-Thway, Aris, Izzuddin M., Chen, Ling-Wei, Quah, Phaik Ling, Tan, Kok Hian, Yeo, George Seow-Heong, Fortier, Marielle V., Yap, Fabian, Shek, Lynette, Chong, Yap-Seng, Gluckman, Peter D., Godfrey, Keith M., Calder, Philip C., Chong, Mary F.F., Kramer, Michael S., Botton, Jérémie, and Lee, Yung Seng

Published
2017
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13. Isolation of single circulating trophoblasts from maternal circulation for noninvasive fetal copy number variant profiling

Author

Doffini, A, Forcato, C, Mangano, C, Lattuada, D, Aversa, R, Maranta, C, Giovannone, E, Buson, G, Bolognesi, C, Maiocchi, R, Dori, M, Jamal, L, Ahmad, R, Yeo, G, Yeo, T, Saragozza, S, Silipigni, R, Serafini, M, Biondi, A, Perego, S, Vergani, P, Ferrazzi, E, Ricciardi-Castagnoli, P, Musci, T, Grati, F, Doffini, Anna, Forcato, Claudio, Mangano, Chiara, Lattuada, Debora, Aversa, Roberta, Maranta, Chiara, Giovannone, Emilia D, Buson, Genny, Bolognesi, Chiara, Maiocchi, Rebecca, Dori, Martina, Jamal, Liyana, Ahmad, Raidah B, Yeo, George S H, Yeo, Tai Wai, Saragozza, Silvia, Silipigni, Rosamaria, Serafini, Marta, Biondi, Andrea, Perego, Sofia, Vergani, Patrizia, Ferrazzi, Enrico, Ricciardi-Castagnoli, Paola, Musci, Thomas J, Grati, Francesca Romana, Doffini, A, Forcato, C, Mangano, C, Lattuada, D, Aversa, R, Maranta, C, Giovannone, E, Buson, G, Bolognesi, C, Maiocchi, R, Dori, M, Jamal, L, Ahmad, R, Yeo, G, Yeo, T, Saragozza, S, Silipigni, R, Serafini, M, Biondi, A, Perego, S, Vergani, P, Ferrazzi, E, Ricciardi-Castagnoli, P, Musci, T, Grati, F, Doffini, Anna, Forcato, Claudio, Mangano, Chiara, Lattuada, Debora, Aversa, Roberta, Maranta, Chiara, Giovannone, Emilia D, Buson, Genny, Bolognesi, Chiara, Maiocchi, Rebecca, Dori, Martina, Jamal, Liyana, Ahmad, Raidah B, Yeo, George S H, Yeo, Tai Wai, Saragozza, Silvia, Silipigni, Rosamaria, Serafini, Marta, Biondi, Andrea, Perego, Sofia, Vergani, Patrizia, Ferrazzi, Enrico, Ricciardi-Castagnoli, Paola, Musci, Thomas J, and Grati, Francesca Romana

Abstract

Objective: To develop a multi-step workflow for the isolation of circulating extravillous trophoblasts (cEVTs) by describing the key steps enabling a semi-automated process, including a proprietary algorithm for fetal cell origin genetic confirmation and copy number variant (CNV) detection. Methods: Determination of the limit of detection (LoD) for submicroscopic CNV was performed by serial experiments with genomic DNA and single cells from Coriell cell line biobank with known imbalances of different sizes. A pregnancy population of 372 women was prospectively enrolled and blindly analyzed to evaluate the current workflow. Results: An LoD of 800 Kb was demonstrated with Coriell cell lines. This level of resolution was confirmed in the clinical cohort with the identification of a pathogenic CNV of 800 Kb, also detected by chromosomal microarray. The mean number of recovered cEVTs was 3.5 cells per sample with a significant reverse linear trend between gestational age and cEVT recovery rate and number of recovered cEVTs. In twin pregnanices, evaluation of zygosity, fetal sex and copy number profiling was performed in each individual cell. Conclusion: Our semi-automated methodology for the isolation and single-cell analysis of cEVTS supports the feasibility of a cell-based noninvasive prenatal test for fetal genomic profiling.

Published
2023

15. Prediction of neonatal respiratory morbidity by quantitative ultrasound lung texture analysis: a multicenter study

Author

Palacio, Montse, Cobo, Teresa, López, Marta, Castro, Dulce, Piraquive, Juan Pablo, Ramírez, Juan Carlos, Migliorelli, Federico, Martínez-Terrón, Mónica, Botet, Francesc, Gratacós, Eduard, Sabrià, Joan, Martínez, Silvia Ferrero, Gómez Roig, Dolores, Bonet-Carné, Elisenda, Pérez, Àlvaro, Domínguez, Mara, Coronado, David, Deprest, Jan, Richter, Jute, DeKoninck, Philip, Kacerovsky, Marian, Musilova, Ivana, Bestvina, Tomas, Maly, Jan, Kokstein, Zdenek, Jacobsson, Bo, Cedergren, Lars, Johansson, Patricia, Tsiartas, Panagiotis, Sävman, Karin, Hallingström, Maria, García Posadas, Raúl, González, Fernando Bugatto, Fajardo, Maria Antonia, Quintero Prado, Rocío, Melero Jiménez, Victoria, Benavente Fernández, Isabel, Prat, Ramon Santisteve, de la Barrera Correa, Benjamín, Valencia, Elena Gómez, Martínez Rodríguez, Raúl, Roma Mas, Elionor, Vives Argilagós, Àngels, Rodríguez Veret, Alejandra, García Cancela, Esperanza, Salinas, Paloma Araujo, Parra-Cordero, Mauro, Sepúlveda-Martínez, Álvaro, Hernández-Andrade, Edgar, Romero, Roberto, Ahn, Hyunyoung, Bartha, José Luis, Antolín, Eugenia, Carretero Lucena, Pilar, Molina García, Francisca, Jiménez Garrido, Noemí, Tallón, Carmen Contreras, Antón, Belén Morillo, Yeo, George, Tan, Kai Lit, Cruz-Martínez, Rogelio, Martínez-Rodríguez, Miguel, Hyatt, Jon, Burke, Minke, Mogra, Ritu, Vavilala, Suseela, Iruretagoyena, J. Igor, Delgado, Juan Luis, Schenone, Mauro, Vilanova, Josep, Bons, Neus, Bonet-Carne, Elisenda, Perez-Moreno, Alvaro, García-Posada, Raúl A., Bugatto, Fernando, Santisteve, Ramon, Vives, Àngels, Hernandez-Andrade, Edgar, Carretero-Lucena, Pilar, Iruretagoyena, Igor, Yeo, George S.H., Hyett, Jon, and Gratacos, Eduard

Published
2017
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16. P616: Cell-based noninvasive prenatal screening for a comprehensive fetal genome profiling for pathogenic submicroscopic CNVs in circulating trophoblasts from maternal blood

Author

Doffini, Anna, primary, Forcato, Claudio, additional, Mangano, Chiara, additional, Lattuada, Debora, additional, Aversa, Roberta, additional, Maranta, Chiara, additional, Giovannone, Emilia, additional, Buson, Genny, additional, Bolognesi, Chiara, additional, Maiocchi, Rebecca, additional, Dori, Martina, additional, Jamal, Liyana, additional, Ahmad, Raidah, additional, Yeo, George S.H., additional, Yeo, Tai Wai, additional, Saragozza, Silvia, additional, Silipigni, Rosamaria, additional, Serafini, Marta, additional, Biondi, Andrea, additional, Perego, Sofia, additional, Vergani, Patrizia, additional, Ferrazzi, Enrico, additional, Ricciardi-Castagnoli, Paola, additional, Musci, Thomas, additional, and Grati, Francesca Romana, additional

Published
2023
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17. Isolation of single circulating trophoblasts from maternal circulation for noninvasive fetal copy number variant profiling

Author

Doffini, Anna, primary, Forcato, Claudio, additional, Mangano, Chiara, additional, Lattuada, Debora, additional, Aversa, Roberta, additional, Maranta, Chiara, additional, Giovannone, Emilia D., additional, Buson, Genny, additional, Bolognesi, Chiara, additional, Maiocchi, Rebecca, additional, Dori, Martina, additional, Jamal, Liyana, additional, Ahmad, Raidah B., additional, Yeo, George S. H., additional, Yeo, Tai Wai, additional, Saragozza, Silvia, additional, Silipigni, Rosamaria, additional, Serafini, Marta, additional, Biondi, Andrea, additional, Perego, Sofia, additional, Vergani, Patrizia, additional, Ferrazzi, Enrico, additional, Ricciardi‐Castagnoli, Paola, additional, Musci, Thomas J., additional, and Grati, Francesca Romana, additional

Published
2022
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18. Prospective evaluation of screening performance of first-trimester prediction models for preterm preeclampsia in an Asian population

Author

Chaemsaithong, Piya, Pooh, Ritsuko K., Zheng, Mingming, Ma, Runmei, Chaiyasit, Noppadol, Tokunaka, Mayumi, Shaw, Steven W., Seshadri, Suresh, Choolani, Mahesh, Wataganara, Tuangsit, Yeo, George S.H., Wright, Alan, Leung, Wing Cheong, Sekizawa, Akihiko, Hu, Yali, Naruse, Katsuhiko, Saito, Shigeru, Sahota, Daljit, Leung, Tak Yeung, and Poon, Liona C.

Published
2019
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20. Association of physical activity and sedentary behavior with depression and anxiety symptoms during pregnancy in a multiethnic cohort of Asian women

Author

Padmapriya, Natarajan, Bernard, Jonathan Y., Liang, Shen, Loy, See Ling, Shen, Zhe, Kwek, Kenneth, Godfrey, Keith M., Gluckman, Peter D., Chong, Yap-Seng, Saw, Seang Mei, Meaney, Michael J., Chen, Helen, Müller-Riemenschneider, Falk, Agarwal, Pratibha, Biswas, Arijit, Bong, Choon Looi, Broekman, Birit F. P., Cai, Shirong, Chan, Jerry Kok Yen, Chan, Yiong Huak, Chee, Cornelia Yin Ing, Cheung, Yin Bun, Chinnadurai, Amutha, Chng, Chai Kiat, Chong, Mary Foong-Fong, Chong, Shang Chee, Chua, Mei Chien, Fok, Doris, Fortier, Marielle V., Goh, Anne Eng Neo, Goh, Yam Thiam Daniel, Gooley, Joshua J., Han, Wee Meng, Hanson, Mark, Henry, Christiani Jeyakumar, Holbrook, Joanna D., Hsu, Chin-Ying, Karnani, Neerja, Kapur, Jeevesh, Lau, Ivy Yee-Man, Lee, Bee Wah, Lee, Yung Seng, Lek, Ngee, Lim, Sok Bee, Magiati, Iliana, Daniel, Lourdes Mary, Ngo, Cheryl, Niduvaje, Krishnamoorthy, Pang, Wei Wei, Qiu, Anqi, Quah, Boon Long, Rajadurai, Victor Samuel, Rauff, Mary, Rebello, Salome A., Richmond, Jenny L., Rifkin-Graboi, Anne, Shek, Lynette Pei-Chi, Sheppard, Allan, Shuter, Borys, Singh, Leher, Soh, Shu-E, Stunkel, Walter, Su, Lin Lin, Tan, Kok Hian, Teoh, Oon Hoe, Tint, Mya Thway, van Bever, Hugo P. S., van Dam, Rob M., Wong, Inez Bik Yun, Wong, P. C., Yap, Fabian, Yeo, George Seow Heong, and On behalf of the GUSTO Study Group

Published
2016
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23. Recent Progress in Polyethylene‐enhanced Organic Phase Change Composite Materials for Energy Management.

Author

Wu, Wen‐Ya, Yeo, George Ming Da, Wang, Suxi, Liu, Zhiyuan, Loh, Xian Jun, and Zhu, Qiang

Subjects
*HEAT storage, *MATERIALS management, *PHASE change materials, *ENERGY management, *ENERGY storage, *SOLAR energy
Abstract

Phase Change Materials (PCMs) are utilized to regulate temperature and store thermal energy in various industries such as infrastructure, electronics, solar power, and more. However, they face several limitations, such as leakage, poor thermal properties, incompatibility, as well as high flammability. Polyethylene (PE) is one of many polymers explored to enhance the desirable properties of PCMs, due to their versatile properties such as high strength, durability, chemical resistance, and low cost. The combination of PCMs and PE can be used to create composite materials, through micro/nano‐ encapsulation, melt‐blending, formation of composites and with proper additives. They create enhanced thermal energy storage properties and in the meantime, benefited from the mechanical properties of the PE. This review provides a concise summary of the recent developments regarding PE‐enhanced PCMs and provides insights into possible topics for further investigation. We summarised enhancement methods based on commonly adopted types of PEs, such as encapsulation, melt‐blending, hot pressing, extrusion, and 3D printing. We then elaborate on how these PE‐PCM composites are effectively utilised for heat management applications and the potential future directions in energy‐saving buildings, electronic devices, and energy storage systems. [ABSTRACT FROM AUTHOR]

Published
2023
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26. OP049: Automated isolation and genetic characterization of single circulating fetal trophoblasts in pregnant women

Author

Forcato, Claudio, primary, Mangano, Chiara, additional, Lattuada, Debora, additional, Aversa, Roberta, additional, Maranta, Chiara, additional, Giovannone, Emilia, additional, Buson, Genny, additional, Bolognesi, Chiara, additional, Maiocchi, Rebecca, additional, Dori, Martina, additional, Jamal, Liyana, additional, Ahmad, Raidah, additional, Yeo, George S.H., additional, Yeo, Tai Wai, additional, Saragozza, Silvia, additional, Serafini, Marta, additional, Biondi, Andrea, additional, Perego, Sofia, additional, Vergani, Patrizia, additional, Ferrazzi, Enrico, additional, Grati, Francesca Romana, additional, and Ricciardi-Castagnoli, Paola, additional

Published
2022
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28. Isolation of single circulating trophoblasts from maternal circulation for noninvasive fetal copy number variant profiling.

Author

Doffini, Anna, Forcato, Claudio, Mangano, Chiara, Lattuada, Debora, Aversa, Roberta, Maranta, Chiara, Giovannone, Emilia D., Buson, Genny, Bolognesi, Chiara, Maiocchi, Rebecca, Dori, Martina, Jamal, Liyana, Ahmad, Raidah B., Yeo, George S. H., Yeo, Tai Wai, Saragozza, Silvia, Silipigni, Rosamaria, Serafini, Marta, Biondi, Andrea, and Perego, Sofia

Abstract

Objective: To develop a multi‐step workflow for the isolation of circulating extravillous trophoblasts (cEVTs) by describing the key steps enabling a semi‐automated process, including a proprietary algorithm for fetal cell origin genetic confirmation and copy number variant (CNV) detection. Methods: Determination of the limit of detection (LoD) for submicroscopic CNV was performed by serial experiments with genomic DNA and single cells from Coriell cell line biobank with known imbalances of different sizes. A pregnancy population of 372 women was prospectively enrolled and blindly analyzed to evaluate the current workflow. Results: An LoD of 800 Kb was demonstrated with Coriell cell lines. This level of resolution was confirmed in the clinical cohort with the identification of a pathogenic CNV of 800 Kb, also detected by chromosomal microarray. The mean number of recovered cEVTs was 3.5 cells per sample with a significant reverse linear trend between gestational age and cEVT recovery rate and number of recovered cEVTs. In twin pregnanices, evaluation of zygosity, fetal sex and copy number profiling was performed in each individual cell. Conclusion: Our semi‐automated methodology for the isolation and single‐cell analysis of cEVTS supports the feasibility of a cell‐based noninvasive prenatal test for fetal genomic profiling. Key points: What's already known about this topic?Fetal circulating extravillous trophoblasts (cEVTs) have been isolated from maternal blood for both aneuploidy and copy number variant (CNV) classification.Previous reported methodologies require mostly manual low throughput workflows and identify putative fetal cells based on immunophenotype. What does this study add?We present a novel semi‐automated workflow for the isolation of circulating fetal trophoblasts and single‐cell genomic profiling of submicroscopic variants.With this methodology, the feasibility of fetal genetic confirmation of each individual cell, a limit of detection (LoD) for CNVs down to 800Kb and the assessment of zygosity, fetal sex and genomic profiling in the same cell in twin pregnancies was demonstrated. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Sonographic spectrum and postnatal outcomes of early-onset versus late-onset fetal cerebral ventriculomegaly.

Author

Bhatia, Anju, Wee Hong Thia, Edwin, Bhatia, Ashwani, Du Ruochen, and Seow Heong Yeo, George

Abstract

Objectives: To review the prenatal characteristics and postnatal outcomes of Early-onset and Late-onset cerebral ventriculomegaly (VM). Methods: Single-center retrospective study 2013-2017; VM cases grouped into Early-onset VM (EVM; Diagnosis at/before 24 weeks) and Late-onset VM (LVM; Beyond 24 weeks). LVM cases had normal ventricle width measurement at mid-trimester scan. Infection serology, cytogenetics, MRI, sonographic follow-up, perinatal and neurodevelopmental outcomes were analyzed. Results: During the 5-year period, 64,662 women underwent an anomaly screening scan and 302 fetuses were identified with ventriculomegaly; 183 (60.6%) classified as early-onset and 119 (39.4%) LVM. The mean ventricular width was significantly higher in LVM cohort (14.1 mm vs 11.6 mm; p < .01). EVM cases were more often associated with structural anomalies (p < .05). Possible etiologies for EVM were aneuploidy and cerebral malformations like Absent Corpus Callosum, spina bifida, Dandy-Walker malformation, etc., whereas LVM followed aqueductal stenosis, hemorrhage, porencephaly, cerebral tumors, etc. Pregnancy outcomes were available for 251 cases. The pregnancy resulted in more live births in LVM group (87.4% vs 65.6%, p = < .01). Multivariate regression analysis demonstrated additional malformations (p < .0001, OR11.5 [95%CI: 4-35.2]), progression of VM (p = .004, OR 10.2 [95% CI: 2.1-52.3]) and severity of VM (OR 5.3 [95%CI: 0.8-37.7]) were significant predictors of Neurodevelopmental Impairment (NDI). Late gestation at diagnosis was more often associated with NDI (p = .063, OR2.4 [95%CI: 0.9-6.2]), although statistically insignificant. Conclusions: EVM has a significantly different sonographic spectrum and outcomes compared to LVM. EVM is milder and associated with an increased risk of aneuploidy and structural malformations. LVM often occurs secondary to acquired brain lesions. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Cohort Profile: Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study

Author

Soh, Shu-E, Tint, Mya Thway, Gluckman, Peter D, Godfrey, Keith M, Rifkin-Graboi, Anne, Chan, Yiong Huak, Stünkel, Walter, Holbrook, Joanna D, Kwek, Kenneth, Chong, Yap-Seng, Saw, Seang Mei, Sheppard, Allan, Chinnadurai, Amutha, Ferguson-Smith, Anne, Goh, Anne Eng Neo, Biswas, Arijit, Chia, Audrey, Leutscher-Broekman, Birit, Shuter, Borys, Cai, Shirong, Ngo, Cheryl, Chng, Chai Kiat, Chong, Shang Chee, Henry, Christiani Jeyakumar, Chua, Mei Chien, Chee, Cornelia Yin Ing, Goh, Yam Thiam Daniel, Bier, Dennis, Ding, Chun Ming, Fok, Doris, Finkelstein, Eric Andrew, Yap, Fabian Kok Peng, Yeo, George Seow Heong, Han, Wee Meng, Chen, Helen, Van Bever, Hugo P S, Inskip, Hazel, Magiati, Iliana, Wong, Inez Bik Yun, Kapur, Jeevesh, Richmond, Jenny L, Chan, Jerry Kok Yen, Gooley, Joshua J, Niduvaje, Krishnamoorthy, Lee, Bee Wah, Lee, Yung Seng, Singh, Leher, Lim, Sok Bee, Daniel, Lourdes Mary, Loh, Seong Feei, Low, Yen-Ling, Shek, Pei-Chi Lynette, Fortier, Marielle, Hanson, Mark, Chong, Mary Foong-Fong, Meaney, Michael, Morton, Susan, Pang, Wei Wei, Agarwal, Pratibha, Qiu, Anqi, Quah, Boon Long, van Dam, Rob M, Stringer, David, Rebello, Salome Antonette, So, Wing Chee, Hsu, Chin-Ying, Su, Lin Lin, Tang, Jenny, Tan, Kok Hian, Tan, Soek Hui, Teoh, Oon Hoe, Rajadurai, Victor Samuel, Wong, PC, and Venkatesh, Sudhakar K

Published
2014
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33. Cohort profile : Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO)

Author

Loo, Evelyn Xiu Ling, Soh, Shu E., Loy, See Ling, Ng, Sharon, Tint, Mya Thway, Chan, Shiao Yng, Huang, Jonathan Yinhao, Yap, Fabian, Tan, Kok Hian, Chern, Bernard S.M., Tan, Heng Hao, Meaney, Michael J., Karnani, Neerja, Godfrey, Keith M., Lee, Yung Seng, Chan, Jerry Kok Yen, Gluckman, Peter D., Chong, Yap Seng, Shek, Lynette Pei Chi, Eriksson, Johan G., Chia, Airu, Fogel, Anna Magdalena, Goh, Anne Eng Neo, Chu, Anne Hin Yee, Rifkin-Graboi, Anne, Qiu, Anqi, Lee, Bee Wah, Cheon, Bobby Kyungbeom, Vaz, Candida, Henry, Christiani Jeyakumar, Forde, Ciaran Gerard, Chi, Claudia, Koh, Dawn Xin Ping, Phua, Desiree Y., Loh, Doris Ngiuk Lan, Quah, Elaine Phaik Ling, Tham, Elizabeth Huiwen, Law, Evelyn Chung Ning, Magkos, Faidon, Mueller-Riemenschneider, Falk, Yeo, George Seow Heong, Yong, Hannah Ee Juen, Chen, Helen Yu, Pan, Hong, van Bever, Hugo P.S., Tan, Hui Min, Aris, Izzuddin Bin Mohd, Tay, Jeannie, Xu, Jia, Yoong, Joanne Su Yin, Loo, Evelyn Xiu Ling, Soh, Shu E., Loy, See Ling, Ng, Sharon, Tint, Mya Thway, Chan, Shiao Yng, Huang, Jonathan Yinhao, Yap, Fabian, Tan, Kok Hian, Chern, Bernard S.M., Tan, Heng Hao, Meaney, Michael J., Karnani, Neerja, Godfrey, Keith M., Lee, Yung Seng, Chan, Jerry Kok Yen, Gluckman, Peter D., Chong, Yap Seng, Shek, Lynette Pei Chi, Eriksson, Johan G., Chia, Airu, Fogel, Anna Magdalena, Goh, Anne Eng Neo, Chu, Anne Hin Yee, Rifkin-Graboi, Anne, Qiu, Anqi, Lee, Bee Wah, Cheon, Bobby Kyungbeom, Vaz, Candida, Henry, Christiani Jeyakumar, Forde, Ciaran Gerard, Chi, Claudia, Koh, Dawn Xin Ping, Phua, Desiree Y., Loh, Doris Ngiuk Lan, Quah, Elaine Phaik Ling, Tham, Elizabeth Huiwen, Law, Evelyn Chung Ning, Magkos, Faidon, Mueller-Riemenschneider, Falk, Yeo, George Seow Heong, Yong, Hannah Ee Juen, Chen, Helen Yu, Pan, Hong, van Bever, Hugo P.S., Tan, Hui Min, Aris, Izzuddin Bin Mohd, Tay, Jeannie, Xu, Jia, and Yoong, Joanne Su Yin

Abstract

The Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) is a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including duration of gestation, fetal growth, metabolic and neural phenotypes in the offspring. Between February 2015 and October 2017, the S-PRESTO study recruited 1039 Chinese, Malay or Indian (or any combinations thereof) women aged 18–45 years and who intended to get pregnant and deliver in Singapore, resulting in 1032 unique participants and 373 children born in the cohort. The participants were followed up for 3 visits during the preconception phase and censored at 12 months of follow up if pregnancy was not achieved (N = 557 censored). Women who successfully conceived (N = 475) were characterised at gestational weeks 6–8, 11–13, 18–21, 24–26, 27–28 and 34–36. Follow up of their index offspring (N = 373 singletons) is on-going at birth, 1, 3 and 6 weeks, 3, 6, 12, 18, 24 and 36 months and beyond. Women are also being followed up post-delivery. Data is collected via interviewer-administered questionnaires, metabolic imaging (magnetic resonance imaging), standardized anthropometric measurements and collection of diverse specimens, i.e. blood, urine, buccal smear, stool, skin tapes, epithelial swabs at numerous timepoints. S-PRESTO has extensive repeated data collected which include genetic and epigenetic sampling from preconception which is unique in mother–offspring epidemiological cohorts. This enables prospective assessment of a wide array of potential determinants of future health outcomes in women from preconception to post-delivery and in their offspring across the earliest development from embryonic stages into early childhood. In addition, the S-PRESTO study draws from the three major Asian ethnic groups that represent 50% of the global population, increa

Published
2021

42. Outcomes following selective fetoscopic laser ablation for twin-to-twin transfusion syndrome: a single-centre experience.

Author

Loh, Michelle, Bhatia, Anju, Kai Lit Tan, Thia, Edwin, Seow Heong Yeo, George, Tan, Kai Lit, and Yeo, George Seow Heong

Subjects
FETOFETAL transfusion, FETOSCOPY, PREMATURE rupture of fetal membranes, ABORTION, LASER ablation, TWINS, SURVIVAL analysis (Biometry), RESEARCH, MEDICAL lasers, RESEARCH methodology, GESTATIONAL age, RETROSPECTIVE studies, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, MULTIPLE pregnancy, SURGERY
Abstract

Introduction: Fetoscopic laser photocoagulation (FLP), a treatment option for twin-to-twin transfusion syndrome (TTTS) in monochorionic twin pregnancies, is currently the treatment of choice at our centre. We previously reported on our experience of FLP from June 2011 to March 2014. This paper audits our fetal surgery performance since then.Methods: 15 consecutive patients who underwent FLP for Stage II-III TTTS before 26 weeks of gestation from June 2011 to January 2017 were retrospectively reviewed, consisting of five cases from our initial experience and ten subsequent cases. Perioperative, perinatal and neonatal outcomes were analysed.Results: Of 15 pregnancies, 10 (66.7%) and 5 (33.3%) were for Stage II and III TTTS respectively, with FLP performed at an earlier Quintero stage in the later cohort. Overall mean gestational ages at presentation, laser and delivery were comparable between the cohorts at 19.7 (15.4-24.3) weeks, 20.3 (16.3-25.0) weeks and 31.2 (27.6-37.0) weeks, respectively. 2 (13.3%) cases had intra-amniotic bleeding and 1 (6.7%) had iatrogenic septostomy. 1 (6.7%) case had persistent TTTS requiring repeat FLP, and another (6.7%) had preterm premature rupture of membranes at seven weeks post procedure. The overall perinatal survival rate was 21 (75.0%) out of 28 infants. One mother underwent termination of pregnancy for social reasons at 1.4 weeks post procedure. Double survival occurred in 8 (57.1%) out of 14 pregnancies, while 13 (92.9%) had at least one survivor.Conclusion: FLP requires a highly specialised team and tertiary neonatal facility. Continual training improves maternal and perinatal outcomes, ensuring comparable standards with international centres. [ABSTRACT FROM AUTHOR]

Published
2020
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43. The COVID-19 pandemic: a letter to G20 leaders

Author

Ahearn, Bertie, Singh Ahluwalia, Montek, Ahmed, Masood, Alphandéry, Edmond, Altwaijri, HE Dr Abdulaziz Altwaijri, Amato, Giuliano, Amersi, Mohamed, Arbour, Louise, Aria, Óscar, Aziz, Shaukat, Bajnai, Gordon, Balkenende, Jan Peter, Banda, HE Joyce, Barak, Ehud, Barletta, Nicolás Ardito, Barroso, José Manuel, Basu, Kaushik, Bazira, Dr Deus, Belka, Marek, Berggruen, Nicolas, Berglöf, Erik, Berisha, Sali, Besley, Timothy, Bildt, Carl, Birkavs, Valdis, Blair, Tony, Bolger, James Brendan, Bondevik, Kjell Magne, Bolton, Patrick, Brahimi, Lakhdar, Brown, Gordon, Brundtland, Gro Harlem, Bruton, John, Calderón, Felipe, Calderón, Rafael Ángel, Cárdenas, Mauricio, Cardoso, Fernando Henrique, Çetin, Hikmet, Chinchilla, Laura, Chissano, HE Joaquim, Cristiani, Alfredo, Clark, Helen, Constantinescu, Emil, Cousin, Ertharin, De Croo, Herman, Cvetković, Mirko, Davies, Gavyn, Đelić, Božidar, Derviş, Kemal, Dreifuss, Ruth, Dybul, Dr Mark, Dzau, Dr Victor J., Dzurinda, Mikuláš, Evans, Gareth, Farrar, Professor Sir Jeremy, Fischer, Jan, Fischer, Joschka, Frattini, Franco, Gaburici, Chiril, Galal, Ahmed, de Gaulle, Nathalie, Gaviria, César, Gonzalez, Felipe, Graham, Dr Hamish, Grenfell, Bryan, Gurib-Fakim, Ameenah, Guriev, Sergei, Gusenbauer, Alfred, Gutiérrez, Lucio, Halonen, Tarja, Hausmann, Ricardo, Ilves, Toomas Hendrik, Holmes, Edward C., Holmström, Bengt, Hurtado, Osvaldo, Ibrahim, Mo, İhsanoğlu, Ekmeleddin, Itzik, Dalia, Ivanić, Mladen, Ivanov, Gjorge, Jilani, Hina, Jomaa, Mehdi, Josipović, Ivo, Karlsson, Mats, Kende-Robb, Caroline, Key, John, Kikwete, HE Jakaya, Ki-Moon, Ban, de Klerk, Frederik Willem, Köhler, Horst, Kosor, Jadranka, Kufuor, HE John, Kumaratunga, Chandrika, Lacalle Herrera, Luis Alberto, Lagos, Ricardo, Lagumdzija, Zlatko, Lamy, Pascal, Lee, Hong-Koo, Leonard, Mark, Leterme, Yves, Letta, Enrico, Lin, Professor Justin Yifu, Livni, Tzipi, Lucinschi, Petru, Lustig, Nora, Machel, Graça, Macri, Mauricio, Mahuad, Jamil, Major, Sir John, Mara, Moussa, Margvelashvili, Giorgi, Martin, Paul, Martinelli, Ricardo, di Mauro, Beatrice Weder, Mbeki, HE Thabo, Medgyessy, Péter, Meidani, Rexhep, Mesić, Stjepan, Mkapa, HE Benjamin, Monti, Mario, Moussa, Amre, Muscat, Joseph, Nakagawa, Dawn, Natsios, Andrew, Nishani, Bujar, Noboa, Gustavo, Obasanjo, Chief Olusegun, Okonjo-Iweala, Dr Ngozi, O'Neill, Lord Jim, Otorbayev, Djoomart, Otunbayeva, Roza, Pagrotsky, Leif, Palacio, Ana, Palmer, Sir Geoffrey, Papandreou, George, Pastrana, Andrés, Patterson, P. J., Pissarides, Christopher, Prodi, Romano, Pronk, Jan, Quiroga, Jorge, Raad al Hussein, Zeid, Radičová, Iveta, Ramos Horta, Jose, Ribas Reig, Òscar, Robinson, Mary, Rodríguez, Miguel Ángel, Rodrik, Dani, Roman, Petre, Rudd, Kevin, Sampaio, Jorge, Sanguinetti, Julio Maria, Santos, Juan Manuel, Satyarthi, Kailash, Schüssel, Wolfgang, Serageldin, Ismail, Sexton, Professor John, Shipley, Dame Jenny, Sirleaf, HE Ellen Johnson, Solana, Javier, Soros, George, Spence, Michael, Sridhar, Devi, Stern, Nicholas, Stiglitz, Joseph, Stoyanov, Petar, Straujuma, Laimdota, Sturzenegger, Federico, Suchocka, Hanna, Summers, Lawrence, Tadić, Boris, von Thadden, Ernst-Ludwig, Thinley, Jigme, Thorning-Schmidt, Helle, Tkeshelashvili, Eka, Trichet, Jean-Claude, Türk, Danilo, Uteem, Cassam, Velasco, Andres, Verhofstadt, Guy, Wantchekon, Leonard, Wei, Shang-Jin, Williams, Dr Rowan, Wolfensohn, James, Yeo, George, Yousafzai, Malala, Yushchenko, Kateryna, Yushchenko, Viktor, Zapatero, José Luis Rodríguez, Zatlers, Valdis, Zedillo, Ernesto, and Zhu, Min

Subjects
RA0421 Public health. Hygiene. Preventive Medicine, HJ Public Finance, HV Social pathology. Social and public welfare. Criminology
Published
2020

49. Dinoprostone vaginal insert (DVI) versus adjunctive sweeping of membranes and DVI for term induction of labor.

Author

Bhatia, Anju, Teo, Puay Ling, Li, Mingyue, Lee, Jia Ying Beatrice, Chan, Mei Xin Joanne, Yeo, Tai Wai, Mathur, Manisha, Tagore, Shephali, Yeo, George S. H., and Arulkumaran, Sabaratnam

Subjects
DRUG efficacy, INDUCED labor (Obstetrics), CONFIDENCE intervals, DINOPROSTONE, MULTIPLE regression analysis, PATIENT satisfaction, CERVIX uteri, PREGNANCY outcomes, RANDOMIZED controlled trials, VAGINA, VAGINAL medication, DESCRIPTIVE statistics, MATERNAL age, LABOR (Obstetrics), STATISTICAL sampling, DELIVERY (Obstetrics), CESAREAN section, ODDS ratio, LONGITUDINAL method, EVALUATION
Abstract

Aim: To compare the efficacy and safety of dinoprostone vaginal insert (DVI) alone versus DVI with adjunctive sweeping of membranes (ASM) for induction of labor (IOL). Methods: Single‐center, prospective, randomized controlled trial; women with singleton term pregnancies, cervical dilation ≥1 and <3 cm, intact membranes allocated to either DVI or DVI with ASM. The primary outcome was vaginal delivery within 24 h of insertion. Secondary outcomes included mean time from insertion to delivery, tachysystole, operative delivery for non‐reassuring fetal status (NRFS), tocolytics, fetal outcomes, pain information, and subject satisfaction. Results: One hundred and four received DVI (Group 1) alone and 104 DVI with ASM (Group 2). The rate of vaginal delivery within 24 h was 53% versus 56%, cesarean rate 8.7% versus 10.6% in Groups 1 and 2 respectively. Although the duration of labor was similar in both groups, about 6% of women required additional ripening with dinoprostone vaginal tablets in Group 2 compared to 11.5% in Group 1 (p‐value = 0.2). The frequency of hyperstimulation syndrome, failed induction, analgesic requirements, and fetal outcomes were comparable. The majority (83%–86%) in either cohort were satisfied with their labor experience. Multivariate logistic regression demonstrated a slightly better chance for vaginal delivery within 24 h (odds ratio [OR] 1.22 [95% confidence interval, CI 0.65–2.29]; p‐value 0.53] for DVI with ASM, although statistically insignificant. Younger maternal age and multiparity (OR 10.36 [95% CI 4.88–23.67]; p‐value <0.0001) contributed to successful IOL. Conclusion: DVI with ASM is at least as efficacious as DVI for cervical ripening with no increase in morbidity. Although DVI with ASM group less often needed additional dinoprostone tablets to complete the process of IOL (p‐value = 0.2), adjunctive sweeping has not been shown to have a significant impact on the duration of labor or mode of delivery. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Additional file 1: of Coverage and determinants of influenza vaccine among pregnant women: a cross-sectional study

Author

Offeddu, Vittoria, Tam, Clarence, Tze Yong, Lay Tan, Koh Thoon, Lee, Nicole, Thiam Tan, Yeo, George, and Yung, Chee

Abstract

Table S1. Details of survey questionnaire. Table S2. Scoring of knowledge questions. Table S3. Exploratory factor analysis. Table S4. Univariable analysis of socio-demographic variables, practices, and cues to vaccination. Table S5. Univariable analysis of knowledge, attitude, and willingness to vaccinate variables (DOCX 290 kb)

Published
2019
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