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To assess risk factors associated with deaths and injuries in a major earthquake area. First, we used the official data including 824 seismic deaths, 271 serious injuries, and 302 moderate injuries to elucidate and compare the demographic, structural, and injury characteristics among the three groups. Secondly, a population based case-control study was conducted to examine how structural factors, medical assistance, personal characteristic, and behavior and preparedness contributed to injury. The age-specific proportions of the three groups were similar and higher in the elderly population. Severity of injuries was proportional to the proportion of completely collapsed houses. Fracture was the most frequently observed among the serious injuries and moderate injuries. Head injury was the major body site caused by the collapsed houses for the seismic deaths. In a case-control study, people who were trapped (adjusted OR = 12.31, 95% CI: 6.29 - 24.28) had the greatest risk of serious injuries, followed by those who were illiterate, in completely collapsed houses, and experienced unprepared flares. This study reveals that improvement in anti-seismic construction, head protect, and literacy education could decrease the effect of disaster. Further, using a flashlight to see in the dark, and moving slowly rather than running should be rigorously recommended as common-sense responses.

Background: Adult asthma is caused by interaction effects of multiple genetic and environmental factors. Some studies have suggested that antioxidant enzyme activity and gene polymorphisms may play important roles in the context of asthma. Therefore, our study objectives were to investigate the association between asthma, antioxidant activities and the polymorphisms of manganese superoxide dismutase (Mn-SOD) or catalase (CAT). Materials and Methods: A case-control study, for which we recruited 250 asthmatic adults and 250 age- and sex-matched controls. All subjects completed a questionnaire. Waist and hip circumference measurements, a lung function test and DNA genotyping were performed. In total, 50 incident cases and 50 matched controls who were non-smokers or had quit smoking for at least 1 year were selected in order to investigate SOD and CAT activity levels. Results: In our study, we did not find a significant association between Mn-SOD Ala16Val, CAT C–262T and asthma. The level of SOD activity in new-onset asthma patients was significantly lower than in control subjects (p < 0.0005). The level of CAT activity in new-onset asthma patients was significantly higher than in control subjects (p < 0.0005). Conclusions: The levels of SOD and CAT activity were significantly related to adult asthma. SOD and CAT activity may be good tools to differentiate potential asthma sufferers. This would enable us to further investigate the mechanism of defective antioxidant enzymes in the context of asthma pathogenesis.

The descriptive study attempts to find house factors associated with earthquake deaths due to the earthquake that struck central Taiwan. Isoseismic area was selected for study to compare building damage and mortality. The rate of houses collapsing increased with intensity of earthquake, inferior constructing, and construction time. According to the ranking by mortality and statistics of death toll in various houses, the poor seismic resistant capacity of mud-brick residence is found to be the major factor that caused great loss of lives. There is 47.6% of the deaths occurred in mud-brick houses though present only 3.8% of all houses. While the reinforced steel concrete buildings had very low damage rate in the major earthquake. Asphyxia and internal hemorrhage were the major cause of deaths in house collapses. These results suggest that improvements in anti-seismic constructing and rescue team efforts could decrease the effect of disaster.

The objective of this study was to explore whether magnesium (Mg) levels in drinking water modified the effects of nitrate on esophageal cancer risk occurrence. A matched cancer case-control study was used to investigate the relationship between the risk of death from esophageal cancer and exposure to nitrate in drinking water in Taiwan. All esophageal cancer deaths of Taiwan residents from 2006 through 2010 were obtained from the Bureau of Vital Statistics of the Taiwan Provincial Department of Health. Controls were deaths from other causes and were pair-matched to cancer cases by gender, year of birth, and year of death. Information on the levels of nitrate-nitrogen (NO(3)-N) and Mg in drinking water were collected from Taiwan Water Supply Corporation (TWSC). The municipality of residence for cancer cases and controls was presumed to be the source of the subject's NO(3)-N and Mg exposure via drinking water. Evidence of an interaction was noted between drinking water NO(3)-N and Mg intake. This is the first study to report effect modification by Mg intake originating from drinking water on an association between NO(3)-N exposure and increased risk mortality attributed to esophageal cancer.

Purpose: Although fire causes 2 % of deaths of the global accidents in Taiwan, injury or death caused by fire is frequent and largely preventable.Approach: Using the Health and Vital Statistics, Fire Losses and Casualties Table, Abridged Life Tables, and Services for Fire Fighting by official publications during 1971-2015, we approached the trends of population, ages, gender, and social costs associated with fatal fire and evaluated the effects of fire safety measures.Results: The higher mortality rate of fire death was in the elders. Fire death rates were 1.92 folds higher risk in males than in females (p < 0.05). The potential years of life lost (PYLL) implied the most efficient evaluation for the fire safety measures. Fire mortality and casualty could be prevented by fire prevention, fire rescue and emergency medical measures effectively. The most significant effect of fire safety measures was evasion training that adopted the indicator of mortality per 102 burned houses (MBH).Conclusions: Therefore, fire prevention efforts should concentrate on males, and elders. The decreasing of fire numbers should be developed and encouraged.

The objectives of this study were (1) to examine the relationship between total trihalomethanes (TTHM) levels in public water supplies and risk of rectal cancer development and (2) to determine whether calcium (Ca) and magnesium (Mg) levels in drinking water might modify the effects of TTHM on risk of developing rectal cancer. A matched cancer case-control study was used to investigate the relationship between the risk of death attributed to rectal cancer and exposure to TTHM in drinking water in 53 municipalities in Taiwan. All rectal cancer deaths in the 53 municipalities from 1998 through 2007 were obtained from the Bureau of Vital Statistics of the Taiwan Provincial Department of Health. Controls were deaths from other causes and were pair-matched to cancer cases by gender, year of birth, and year of death. Each matched control was selected randomly from the set of possible controls for each cancer case. Data on TTHM levels in drinking water were collected from the Taiwan Environmental Protection Administration. Information on the levels of Ca and Mg in drinking water was obtained from the Taiwan Water Supply Corporation. The municipality of residence for cancer cases and controls was presumed to be the source of the subject's TTHM, Ca, and Mg exposure via drinking water. Relative to individuals whose TTHM exposure level was or=4.9 ppb. There was no evidence of an interaction of drinking-water TTHM levels with low Ca intake via drinking water. However, evidence of an interaction was noted between drinking-water TTHM concentrations and Mg intake via drinking water. Our findings showed that the correlation between TTHM exposure and risk of rectal cancer is influenced by Mg in drinking water. Increased knowledge of the interaction between Mg and TTHM in reducing rectal cancer risk will aid in public policymaking and standard setting.

To investigate the relationship between air pollution and risk of death attributed to gastric cancer, a matched cancer case-control study was conducted using deaths that occurred in Taiwan from 2004 through 2008. Data for all eligible gastric cancer deaths were obtained and compared to a control group consisting of individuals who died from causes other than neoplasms and diseases that were associated with gastrointestinal (GIT) disorders. The controls were pair-matched to the cancer cases by gender, year of birth, and year of death. Each matched control was randomly selected from the set of possible controls for each cancer case. Data for the number of petrol stations in study municipalities were collected from two major petroleum supply companies. The petrol station density (per square kilometer) (PSD) for study municipalities was used as an indicator of a subject's exposure to benzene and other hydrocarbons present in ambient evaporative losses of petrol or to air emissions from motor vehicles. The exposed individuals were subdivided into three categories (≤25th percentile; 25th-75th percentile;75th percentile) according to PSD in the residential municipality. Results showed that individuals who resided in municipalities with the highest PSD were at an increased risk of death attributed to gastric cancer compared to those subjects living in municipalities with the lowest PSD. The findings of this study warrant further investigation of the role of traffic air pollution exposure in the etiology of gastric cancer.

Purpose: To determine whether chromium, cadmium, and lead levels in human Fingernails reflected the exposure to workplace contamination in tanneries.Approach: 49 exposed tanning workers and 33 controls were monitored for fingernail levels of chromium, cadmium, and lead by graphite furnace and hydride atomic absorption spectroscopy.Results: The mean levels of fingernail chromium, cadmium, and lead in the exposed workers were significantly higher than those in the controls. In regression models for the tannery workers, the significant risk factor that affected the fingernail chromium, Cadmium, and lead level were occupational exposure, respectively. Current smoker it showed a significant change in trend of increased fingernail cadmium levels.Conclusion: These findings indicate that chromium, cadmium, and lead absorbed from. Leather tanning compounds result in raised levels of chromium, cadmium, and lead in fingernails and that improvement of the industrial health should be more practiced in the tanneries in Taiwan.

Purpose: To follow up the hematological changes in petroleum workers with continuous exposure to benzene.Approach: The hematological data of two petroleum company male employees was obtained from the annual health check-ups during 2001 to 2005. Workers were classified into exposed and unexposed groups on the basis of their exposure operation performed, and the industrial hygiene surveys.Results: There was not any difference between the exposed and the unexposed groups in the frequency of abnormalities with CBC differential and WBC differential almost. The frequency of higher than the normal range with eosinophils was significantly higher in exposed group (31.73%) than in unexposed group (11.54%, p < 0.05) in 1994, only.Conclusion: The study suggested that the eosinophil counts could be a hematological effect maker among workers exposed to benzene in the petroleum industry.

Objective The objective of this study was to investigate whether exposure to aluminum, gallium, indium, arsenic, and antimony induces lipid peroxidation in humans. Methods Whole blood and urine levels of 103 exposed electronic industry workers and 67 referents were analyzed by use of inductively coupled plasma mass spectrometry. Malondialdehyde (MDA), the product of lipid peroxidation, was determined by high-performance liquid chromatography. Results The mean plasma MDA level in the 103 workers was significantly higher than that in 67 referents. The levels of MDA in the exposed workers were correlated significantly with the levels of urinary gallium and arsenic. Conclusions Malondialdehyde as an index of lipid peroxidation can be induced by gallium and arsenic exposure. By reducing exposure to these metals, biologic effects such as lipid peroxidation may also be diminished.

In this study, the authors attempted to determine factors associated with earthquake deaths in the great Chi-Chi Earthquake that occurred on September 21, 1999, in Taiwan. An isoseismal map was used to identify life-threatening hazards. The vertical peak ground acceleration of ground motion intensity was deemed the most appropriate index for the evaluation of building collapse and mortality. Mortality increased with the increase in earthquake intensity, and building collapse, approaching the epicenter. The greatest number of collapsed buildings and human deaths occurred between the Chelungpu Fault and the Shuantun Fault. Individuals 65 yr of age and older were the most vulnerable to the impact. The authors' findings suggest that improvements in earthquake-resistant building design and construction, as well as improved medical rescue for the elderly, could reduce the level of exposure to earthquake hazards.

Purpose: To monitor whether the relief including food, and supplies met the need for the Typhoon Morakot victims. Approach: Relief data was obtained from the Relief Coordination Center (RCC), Pingtung County Government during July 10 to July 28, 2009. The relief was classified into food and supplies categories. Results: The most need of relief was cleaner necessaries (8/15 = 53.3 %), the last need of relief was seasoning (0/15 = 0 %). The subjects including eggs, bread, cloths, socks, lighter, and candle were not required by the victims although they were donated by people. Conclusion: The several catchment areas in Pingtung County needed to be cleaned after the flooding. Therefore, the kind of cleaner necessaries was the most as well as the longest need of relief expectantly. Our results suggest the priorities of resources allocation for the next disaster. Keywords: Typhoon Morakot, Cleaner Necessaries, Resource Allocation.

Purpose To investigate the basic and medical needs of 258 serious injuries in the Chi-Chi earthquake. Approach Subjects were collected from the Department of public Health Bureau, Nantou County Government. The participants were asked to complete the questionnaire about the basic and medical needs 5 months after the earthquake struck. Results There were 13 died, 8 still in hospital, and 250 discharged of the 271 serious injuries. Among the 250 discharged persons, 28 (11.2 %) needed home rehabilitation, 206 (82.4 %) needed hospital rehabilitation routinely, and 16 (6.4 %) cases were cured. The unemployment got the living fee less self-reliant than the employment (odds ratio = 214.67, 95 % confidence interval = 53.22 865.83). The unemployment needed the employment service more than the employment (odds ratio = 5.37, 95 % confidence interval = 1.20 23.94) also. There were no difference between the unemployment and employment for the needs of home rehabilitation, mental counseling, financial support, vocational training, and accommodation service. These analyses suggested that provides both the extent rehabilitation service and job service for the still unemployed as the major strategies for serious injuries in Taiwan.