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3. Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer

Author

Harvey-Jones, E., Raghunandan, M., Robbez-Masson, L., Magraner-Pardo, L., Alaguthurai, T., Yablonovitch, A., Yen, J., Xiao, H., Brough, R., Frankum, J., Song, F., Yeung, J., Savy, T., Gulati, A., Alexander, J., Kemp, H., Starling, C., Konde, A., Marlow, R., Cheang, M., Proszek, P., Hubank, M., Cai, M., Trendell, J., Lu, R., Liccardo, R., Ravindran, N., Llop-Guevara, A., Rodriguez, O., Balmana, J., Lukashchuk, N., Dorschner, M., Drusbosky, L., Roxanis, I., Serra, V., Haider, S., Pettitt, S.J., Lord, C.J., and Tutt, A.N.J.

Published
2024
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5. Spatial Imaging of Charge Transport in Silicon at Low Temperature

Author

Moffatt, R. A., Kurinsky, N. A., Stanford, C., Allen, J., Brink, P. L., Cabrera, B., Cherry, M., Inuslla, F., Ponce, F., Sundqvist, K., Yellin, S., Yen, J. J., and Young, B. A.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We present direct imaging measurements of charge transport across a 1 cm$\times$ 1 cm$\times$ 4 mm crystal of high purity silicon ($\sim$20 k$\Omega$cm) at temperatures between 500 mK and and 5 K. We use these data to determine the intervalley scattering rate of electrons as a function of the electric field applied along the $\langle 111 \rangle$ crystal axis, and we present a phenomenological model of intervalley scattering that explains the constant scattering rate seen at low-voltage for cryogenic temperatures. We also demonstrate direct imaging measurements of effective hole mass anisotropy, which is strongly dependent on both temperature and electric field strength. The observed effects can be explained by a warping of the valence bands for carrier energies near the spin-orbit splitting energy in silicon., Comment: 5 Pages, 5 Figures. Submitted to Applied Physics Letters

Published
2018
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6. Nuclear-recoil energy scale in CDMS II silicon dark-matter detectors

Author

Agnese, R., Anderson, A. J., Aramaki, T., Baker, W., Balakishiyeva, D., Banik, S., Barker, D., Thakur, R. Basu, Bauer, D. A., Binder, T., Borgland, A., Bowles, M. A., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Calkins, R., Cartaro, C., Cerdeno, D. G., Chagani, H., Chang, Y. -Y., Chen, Y., Cooley, J., Cornell, B., Cushman, P., Daal, M., Doughty, T., Dragowsky, E. M., Esteban, L., Fallows, S., Fascione, E., Figueroa-Feliciano, E., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, H. R., Holmgren, D., Hong, Z., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Jastram, A., Jena, C., Kelsey, M. H., Kennedy, A., Kubik, A., Kurinsky, N. A., Leder, A., Asamar, E. Lopez, Lukens, P., MacDonell, D., Mahapatra, R., Mandic, V., Mast, N., McCarthy, K. A., Miller, E. H., Mirabolfathi, N., Moffatt, R. A., Mohanty, B., Moore, D., Mendoza, J. D. Morales, Nelson, J., Oser, S. M., Page, K., Page, W. A., Partridge, R., Martinez, M. Penalver, Pepin, M., Phipps, A., Poudel, S., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Roberts, A., Rogers, H. E., Robinson, A. E., Saab, T., Sadoulet, B., Sander, J., Schneck, K., Schnee, R. W., Scorza, S., Senapati, K., Serfass, B., Speller, D., Di Stefano, P. C. F., Stein, M., Street, J., Tanaka, H. A., Toback, D., Underwood, R., Villano, A. N., von Krosigk, B., Welliver, B., Wilson, J. S., Wilson, M. J., Wright, D. H., Yellin, S., Yen, J. J., Young, B. A., Zhang, X., and Zhao, X.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

The Cryogenic Dark Matter Search (CDMS II) experiment aims to detect dark matter particles that elastically scatter from nuclei in semiconductor detectors. The resulting nuclear-recoil energy depositions are detected by ionization and phonon sensors. Neutrons produce a similar spectrum of low-energy nuclear recoils in such detectors, while most other backgrounds produce electron recoils. The absolute energy scale for nuclear recoils is necessary to interpret results correctly. The energy scale can be determined in CDMS II silicon detectors using neutrons incident from a broad-spectrum $^{252}$Cf source, taking advantage of a prominent resonance in the neutron elastic scattering cross section of silicon at a recoil (neutron) energy near 20 (182) keV. Results indicate that the phonon collection efficiency for nuclear recoils is $4.8^{+0.7}_{-0.9}$% lower than for electron recoils of the same energy. Comparisons of the ionization signals for nuclear recoils to those measured previously by other groups at higher electric fields indicate that the ionization collection efficiency for CDMS II silicon detectors operated at $\sim$4 V/cm is consistent with 100% for nuclear recoils below 20 keV and gradually decreases for larger energies to $\sim$75% at 100 keV. The impact of these measurements on previously published CDMS II silicon results is small., Comment: 22 pages, 17 figures, 1 table, 1 appendix

Published
2018
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7. Thermal detection of single e-h pairs in a biased silicon crystal detector

Author

Romani, R. K., Brink, P. L., Cabrera, B., Cherry, M., Howarth, T., Kurinsky, N., Moffatt, R. A., Partridge, R., Ponce, F., Pyle, M., Tomada, A., Yellin, S., Yen, J. J., and Young, B. A.

Subjects
Physics - Instrumentation and Detectors
Abstract

We demonstrate that individual electron-hole pairs are resolved in a 1 cm$^2$ by 4 mm thick silicon crystal (0.93 g) operated at $\sim$35 mK. One side of the detector is patterned with two quasiparticle-trap-assisted electro-thermal-feedback transition edge sensor (QET) arrays held near ground potential. The other side contains a bias grid with 20\% coverage. Bias potentials up to $\pm$ 160 V were used in the work reported here. A fiber optic provides 650~nm (1.9 eV) photons that each produce an electron-hole ($e^{-} h^{+}$) pair in the crystal near the grid. The energy of the drifting charges is measured with a phonon sensor noise $\sigma$ $\sim$0.09 $e^{-} h^{+}$ pair. The observed charge quantization is nearly identical for $h^+$'s or $e^-$'s transported across the crystal., Comment: 4 journal pages, 5 figures

Published
2017
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8. Results from the Super Cryogenic Dark Matter Search (SuperCDMS) experiment at Soudan

Author

SuperCDMS Collaboration, Agnese, R., Aramaki, T., Arnquist, I. J., Baker, W., Balakishiyeva, D., Banik, S., Barker, D., Thakur, R. Basu, Bauer, D. A., Binder, T., Bowles, M. A., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Calkins, R., Cartaro, C., Cerdeño, D. G., Chang, Y., Chen, Y., Cooley, J., Cornell, B., Cushman, P., Daal, M., Di Stefano, P. C. F., Doughty, T., Fascione, E., Figueroa-Feliciano, E., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, H. R., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Jastram, A., Jena, C., Kelsey, M. H., Kennedy, A., Kubik, A., Kurinsky, N. A., Loer, B., Asamar, E. Lopez, Lukens, P., MacDonell, D., Mahapatra, R., Mandic, V., Mast, N., Miller, E. H., Mirabolfathi, N., Mohanty, B., Mendoza, J. D. Morales, Nelson, J., Orrell, J. L., Oser, S. M., Page, K., Page, W. A., Partridge, R., Martinez, M. Penalver, Pepin, M., Phipps, A., Poudel, S., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Reynolds, T., Roberts, A., Robinson, A. E., Rogers, H. E., Saab, T., Sadoulet, B., Sander, J., Schneck, K., Schnee, R. W., Scorza, S., Senapati, K., Serfass, B., Speller, D., Stein, M., Street, J., Tanaka, H. A., Toback, D., Underwood, R., Villano, A. N., von Krosigk, B., Welliver, B., Wilson, J. S., Wilson, M. J., Wright, D. H., Yellin, S., Yen, J. J., Young, B. A., Zhang, X., and Zhao, X.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We report the result of a blinded search for Weakly Interacting Massive Particles (WIMPs) using the majority of the SuperCDMS Soudan dataset. With an exposure of 1690 kg days, a single candidate event is observed, consistent with expected backgrounds. This analysis (combined with previous Ge results) sets an upper limit on the spin-independent WIMP--nucleon cross section of $1.4 \times 10^{-44}$ ($1.0 \times 10^{-44}$) cm$^2$ at 46 GeV/$c^2$. These results set the strongest limits for WIMP--germanium-nucleus interactions for masses $>$12 GeV/$c^2$.

Published
2017
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9. Low-Mass Dark Matter Search with CDMSlite

Author

SuperCDMS Collaboration, Agnese, R., Anderson, A. J., Aralis, T., Aramaki, T., Arnquist, I. J., Baker, W., Balakishiyeva, D., Barker, D., Thakur, R. Basu, Bauer, D. A., Binder, T., Bowles, M. A., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Calkins, R., Cartaro, C., Cerdeno, D. G., Chang, Y., Chagani, H., Chen, Y., Cooley, J., Cornell, B., Cushman, P., Daal, M., Di Stefano, P. C. F., Doughty, T., Esteban, L., Fascione, E., Figueroa-Feliciano, E., Fritts, M., Gerbier, G., Ghaith, M., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, H. R., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Jastram, A., Jena, C., Kelsey, M. H., Kennedy, A., Kubik, A., Kurinsky, N. A., Leder, A., Loer, B., Asamar, E. Lopez, Lukens, P., MacDonell, D., Mahapatra, R., Mandic, V., Mast, N., Miller, E. H., Mirabolfathi, N., Moffatt, R. A., Mohanty, B., Mendoza, J. D. Morales, Nelson, J., Orrell, J. L., Oser, S. M., Page, K., Page, W. A., Partridge, R., Pepin, M., Martinez, M. Penalver, Phipps, A., Poudel, S., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Reynolds, T., Roberts, A., Robinson, A. E., Rogers, H. E., Saab, T., Sadoulet, B., Sander, J., Schneck, K., Schnee, R. W., Scorza, S., Senapati, K., Serfass, B., Speller, D., Stein, M., Street, J., Tanaka, H. A., Toback, D., Underwood, R., Villano, A. N., von Krosigk, B., Welliver, B., Wilson, J. S., Wilson, M. J, Wright, D. H., Yellin, S., Yen, J. J., Young, B. A., Zhang, X., and Zhao, X.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The SuperCDMS experiment is designed to directly detect weakly interacting massive particles (WIMPs) that may constitute the dark matter in our Galaxy. During its operation at the Soudan Underground Laboratory, germanium detectors were run in the CDMSlite mode to gather data sets with sensitivity specifically for WIMPs with masses ${<}$10 GeV/$c^2$. In this mode, a higher detector-bias voltage is applied to amplify the phonon signals produced by drifting charges. This paper presents studies of the experimental noise and its effect on the achievable energy threshold, which is demonstrated to be as low as 56 eV$_{\text{ee}}$ (electron equivalent energy). The detector-biasing configuration is described in detail, with analysis corrections for voltage variations to the level of a few percent. Detailed studies of the electric-field geometry, and the resulting successful development of a fiducial parameter, eliminate poorly measured events, yielding an energy resolution ranging from ${\sim}$9 eV$_{\text{ee}}$ at 0 keV to 101 eV$_{\text{ee}}$ at ${\sim}$10 eV$_{\text{ee}}$. New results are derived for astrophysical uncertainties relevant to the WIMP-search limits, specifically examining how they are affected by variations in the most probable WIMP velocity and the Galactic escape velocity. These variations become more important for WIMP masses below 10 GeV/$c^2$. Finally, new limits on spin-dependent low-mass WIMP-nucleon interactions are derived, with new parameter space excluded for WIMP masses $\lesssim$3 GeV/$c^2$, Comment: 30 Pages, 33 Figures v3 to match published version in PRD. v2 contains public release (and documentation) of the CDMSlite Run 2 data as ancillary files

Published
2017
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10. Projected Sensitivity of the SuperCDMS SNOLAB experiment

Author

Agnese, R., Anderson, A. J., Aramaki, T., Arnquist, I., Baker, W., Barker, D., Thakur, R. Basu, Bauer, D. A., Borgland, A., Bowles, M. A., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Calkins, R., Cartaro, C., Cerdeño, D. G., Chagani, H., Chen, Y., Cooley, J., Cornell, B., Cushman, P., Daal, M., Di Stefano, P. C. F., Doughty, T., Esteban, L., Fallows, S., Figueroa-Feliciano, E., Fritts, M., Gerbier, G., Ghaith, M., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, H. R., Hofer, T., Holmgren, D., Hong, Z., Hoppe, E., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Jastram, A., Kelsey, M. H., Kennedy, A., Kubik, A., Kurinsky, N. A., Leder, A., Loer, B., Asamar, E. Lopez, Lukens, P., Mahapatra, R., Mandic, V., Mast, N., Mirabolfathi, N., Moffatt, R. A., Mendoza, J. D. Morales, Orrell, J. L., Oser, S. M., Page, K., Page, W. A., Partridge, R., Pepin, M., Phipps, A., Poudel, S., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Roberts, A., Robinson, A. E., Rogers, H. E., Saab, T., Sadoulet, B., Sander, J., Schneck, K., Schnee, R. W., Serfass, B., Speller, D., Stein, M., Street, J., Tanaka, H. A., Toback, D., Underwood, R., Villano, A. N., von Krosigk, B., Welliver, B., Wilson, J. S., Wright, D. H., Yellin, S., Yen, J. J., Young, B. A., Zhang, X., and Zhao, X.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment
Abstract

SuperCDMS SNOLAB will be a next-generation experiment aimed at directly detecting low-mass (< 10 GeV/c$^2$) particles that may constitute dark matter by using cryogenic detectors of two types (HV and iZIP) and two target materials (germanium and silicon). The experiment is being designed with an initial sensitivity to nuclear recoil cross sections ~ 1 x 10$^{-43}$ cm$^2$ for a dark matter particle mass of 1 GeV/c$^2$, and with capacity to continue exploration to both smaller masses and better sensitivities. The phonon sensitivity of the HV detectors will be sufficient to detect nuclear recoils from sub-GeV dark matter. A detailed calibration of the detector response to low energy recoils will be needed to optimize running conditions of the HV detectors and to interpret their data for dark matter searches. Low-activity shielding, and the depth of SNOLAB, will reduce most backgrounds, but cosmogenically produced $^{3}$H and naturally occurring $^{32}$Si will be present in the detectors at some level. Even if these backgrounds are x10 higher than expected, the science reach of the HV detectors would be over three orders of magnitude beyond current results for a dark matter mass of 1 GeV/c$^2$. The iZIP detectors are relatively insensitive to variations in detector response and backgrounds, and will provide better sensitivity for dark matter particle masses (> 5 GeV/c$^2$). The mix of detector types (HV and iZIP), and targets (germanium and silicon), planned for the experiment, as well as flexibility in how the detectors are operated, will allow us to maximize the low-mass reach, and understand the backgrounds that the experiment will encounter. Upgrades to the experiment, perhaps with a variety of ultra-low-background cryogenic detectors, will extend dark matter sensitivity down to the "neutrino floor", where coherent scatters of solar neutrinos become a limiting background., Comment: SuperCDMS SNOLAB Projected sensitivity reach

Published
2016
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12. WIMP-Search Results from the Second CDMSlite Run

Author

SuperCDMS Collaboration, Agnese, R., Anderson, A. J., Aramaki, T., Asai, M., Baker, W., Balakishiyeva, D., Barker, D., Thakur, R. Basu, Bauer, D. A., Billard, J., Borgland, A., Bowles, M. A., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Calkins, R., Cerdeno, D. G., Chagani, H., Chen, Y., Cooley, J., Cornell, B., Cushman, P., Daal, M., Di Stefano, P. C. F., Doughty, T., Esteban, L., Fallows, S., Figueroa-Feliciano, E., Ghaith, M., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, H. R., Hofer, T., Holmgren, D., Hsu, L., Huber, M. E., Jardin, D., Jastram, A., Kamaev, O., Kara, B., Kelsey, M. H., Kennedy, A., Leder, A., Loer, B., Asamar, E. Lopez, Lukens, P., Mahapatra, R., Mandic, V., Mast, N., Mirabolfathi, N., Moffatt, R. A., Mendoza, J. D. Morales, Oser, S. M., Page, K., Page, W. A., Partridge, R., Pepin, M., Phipps, A., Prasad, K., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Ricci, Y., Roberts, A., Rogers, H. E., Saab, T., Sadoulet, B., Sander, J., Schneck, K., Schnee, R. W., Scorza, S., Serfass, B., Shank, B., Speller, D., Toback, D., Underwood, R., Upadhyayula, S., Villano, A. N., Welliver, B., Wilson, J. S., Wright, D. H., Yellin, S., Yen, J. J., Young, B. A., and Zhang, J.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The CDMS low ionization threshold experiment (CDMSlite) uses cryogenic germanium detectors operated at a relatively high bias voltage to amplify the phonon signal in the search for weakly interacting massive particles (WIMPs). Results are presented from the second CDMSlite run with an exposure of 70 kg days, which reached an energy threshold for electron recoils as low as 56 eV. A fiducialization cut reduces backgrounds below those previously reported by CDMSlite. New parameter space for the WIMP-nucleon spin-independent cross section is excluded for WIMP masses between 1.6 and 5.5 GeV/$c^2$., Comment: 6 pages, 4 figures. v2 Matches the accepted version in PRL

Published
2015
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13. Imaging the Oblique Propagation of Electrons in Germanium Crystals at Low Temperature and Low Electric Field

Author

Moffatt, R. A., Cabrera, B., Corcoran, B. M., Kreikebaum, J. M., Redl, P., Shank, B., Yen, J. J., Young, B. A., Brink, P. L., Cherry, M., Tomada, A., Phipps, A., Sadoulet, B., and Sundqvist, K. M.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Excited electrons in the conduction band of germanium collect into four energy minima, or valleys, in momentum space. These local minima have highly anisotropic mass tensors which cause the electrons to travel in directions which are oblique to an applied electric field at sub-Kelvin temperatures and low electric fields, in contrast to the more isotropic behavior of the holes. This experiment produces, for the first time, a full two-dimensional image of the oblique electron and hole propagation and the quantum transitions of electrons between valleys for electric fields oriented along the [0,0,1] direction. Charge carriers are excited with a focused laser pulse on one face of a germanium crystal and then drifted through the crystal by a uniform electric field of strength between 0.5 and 6 V/cm. The pattern of charge density arriving on the opposite face is used to reconstruct the trajectories of the carriers. Measurements of the two-dimensional pattern of charge density are compared in detail with Monte Carlo simulations developed for the Cryogenic Dark Matter Search (CDMS) to model the transport of charge carriers in high-purity germanium detectors.

Published
2015
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14. Improved WIMP-search reach of the CDMS II germanium data

Author

Agnese, R., Anderson, A. J., Asai, M., Balakishiyeva, D., Barker, D., Thakur, R. Basu, Bauer, D. A., Billard, J., Borgland, A., Bowles, M. A., Brandt, D., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Calkins, R., Cerdeño, D. G., Chagani, H., Chen, Y., Cooley, J., Cornell, B., Crewdson, C. H., Cushman, P., Daal, M., Di Stefano, P. C. F., Doughty, T., Esteban, L., Fallows, S., Figueroa-Feliciano, E., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, H. R., Hertel, S. A., Hofer, T., Holmgren, D., Hsu, L., Huber, M. E., Jardin, D., Jastram, A., Kamaev, O., Kara, B., Kelsey, M. H., Kennedy, A., Kiveni, M., Koch, K., Leder, A., Loer, B., Asamar, E. Lopez, Lukens, P., Mahapatra, R., Mandic, V., McCarthy, K. A., Mirabolfathi, N., Moffatt, R. A., Oser, S. M., Page, K., Page, W. A., Partridge, R., Pepin, M., Phipps, A., Prasad, K., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Ricci, Y., Rogers, H. E., Saab, T., Sadoulet, B., Sander, J., Schneck, K., Schnee, R. W., Scorza, S., Serfass, B., Shank, B., Speller, D., Toback, D., Upadhyayula, S., Villano, A. N., Welliver, B., Wilson, J. S., Wright, D. H., Yang, X., Yellin, S., Yen, J. J., Young, B. A., and Zhang, J.

Subjects
High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

CDMS II data from the 5-tower runs at the Soudan Underground Laboratory were reprocessed with an improved charge-pulse fitting algorithm. Two new analysis techniques to reject surface-event backgrounds were applied to the 612 kg days germanium-detector WIMP-search exposure. An extended analysis was also completed by decreasing the 10 keV analysis threshold to $\sim$5 keV, to increase sensitivity near a WIMP mass of 8 GeV/$c^2$. After unblinding, there were zero candidate events above a deposited energy of 10 keV and 6 events in the lower-threshold analysis. This yielded minimum WIMP-nucleon spin-independent scattering cross-section limits of $1.8 \times 10^{-44}$ and $1.18 \times 10 ^{-41}$ cm$^2$ at 90\% confidence for 60 and 8.6 GeV/$c^2$ WIMPs, respectively. This improves the previous CDMS II result by a factor of 2.4 (2.7) for 60 (8.6) GeV/$c^2$ WIMPs., Comment: 25 pages, 15 figures, slightly updated organization and text consistent with PRD referee process, Fig. 14 updated

Published
2015
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15. Dark matter effective field theory scattering in direct detection experiments

Author

Schneck, K., Cabrera, B., Cerdeno, D. G., Mandic, V., Rogers, H. E., Agnese, R., Anderson, A. J., Asai, M., Balakishiyeva, D., Barker, D., Thakur, R. Basu, Bauer, D. A., Billard, J., Borgland, A., Brandt, D., Brink, P. L., Bunker, R., Caldwell, D. O., Calkins, R., Chagani, H., Chen, Y., Cooley, J., Cornell, B., Crewdson, C. H., Cushman, P., Daal, M., Di Stefano, P. C. F., Doughty, T., Esteban, L., Fallows, S., Figueroa-Feliciano, E., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, H. R., Hofer, T., Holmgren, D., Hsu, L., Huber, M. E., Jardin, D. M., Jastram, A., Kamaev, O., Kara, B., Kelsey, M. H., Kennedy, A., Leder, A., Loer, B., Asamar, E. Lopez, Lukens, P., Mahapatra, R., McCarthy, K. A., Mirabolfathi, N., Moffatt, R. A., Mendoza, J. D. Morales, Oser, S. M., Page, K., Page, W. A., Partridge, R., Pepin, M., Phipps, A., Prasad, K., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Ricci, Y., Roberts, A., Saab, T., Sadoulet, B., Sander, J., Schnee, R. W., Scorza, S., Serfass, B., Shank, B., Speller, D., Toback, D., Upadhyayula, S., Villano, A. N., Welliver, B., Wilson, J. S., Wright, D. H., Yang, X., Yellin, S., Yen, J. J., Young, B. A., and Zhang, J.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We examine the consequences of the effective field theory (EFT) of dark matter-nucleon scattering for current and proposed direct detection experiments. Exclusion limits on EFT coupling constants computed using the optimum interval method are presented for SuperCDMS Soudan, CDMS II, and LUX, and the necessity of combining results from multiple experiments in order to determine dark matter parameters is discussed. We demonstrate that spectral differences between the standard dark matter model and a general EFT interaction can produce a bias when calculating exclusion limits and when developing signal models for likelihood and machine learning techniques. We also discuss the implications of the EFT for the next-generation (G2) direct detection experiments and point out regions of complementarity in the EFT parameter space., Comment: Newest version includes erratum

Published
2015
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17. Maximum Likelihood Analysis of Low Energy CDMS II Germanium Data

Author

SuperCDMS Collaboration, Agnese, R., Anderson, A. J., Balakishiyeva, D., Thakur, R. Basu, Bauer, D. A., Billard, J., Borgland, A., Bowles, M. A., Brandt, D., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Cerdeno, D. G., Chagani, H., Chen, Y., Cooley, J., Cornell, B., Crewdson, C. H., Cushman, P., Daal, M., Di Stefano, P. C. F., Doughty, T., Esteban, L., Fallows, S., Figueroa-Feliciano, E., Fritts, M., Godfrey, G. L., Golwala, S. R., Graham, M., Hall, J., Harris, H. R., Hertel, S. A., Hofer, T., Holmgren, D., Hsu, L., Huber, M. E., Jastram, A., Kamaev, O., Kara, B., Kelsey, M. H., Kennedy, A., Kiveni, M., Koch, K., Leder, A., Loer, B., Asamar, E. Lopez, Mahapatra, R., Mandic, V., Martinez, C., McCarthy, K. A., Mirabolfathi, N., Moffatt, R. A., Moore, D. C., Nelson, R. H., Oser, S. M., Page, K., Page, W. A., Partridge, R., Pepin, M., Phipps, A., Prasad, K., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Ricci, Y., Rogers, H. E., Saab, T., Sadoulet, B., Sander, J., Schneck, K., Schnee, R. W., Scorza, S., Serfass, B., Shank, B., Speller, D., Upadhyayula, S., Villano, A. N., Welliver, B., Wright, D. H., Yellin, S., Yen, J. J., Young, B. A., and Zhang, J.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

We report on the results of a search for a Weakly Interacting Massive Particle (WIMP) signal in low-energy data of the Cryogenic Dark Matter Search (CDMS~II) experiment using a maximum likelihood analysis. A background model is constructed using GEANT4 to simulate the surface-event background from $^{210}$Pb decay-chain events, while using independent calibration data to model the gamma background. Fitting this background model to the data results in no statistically significant WIMP component. In addition, we perform fits using an analytic ad hoc background model proposed by Collar and Fields, who claimed to find a large excess of signal-like events in our data. We confirm the strong preference for a signal hypothesis in their analysis under these assumptions, but excesses are observed in both single- and multiple-scatter events, which implies the signal is not caused by WIMPs, but rather reflects the inadequacy of their background model., Comment: 12 pages, 12 figures, submitted to PRD

Published
2014
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18. First direct limits on Lightly Ionizing Particles with electric charge less than $e/6$

Author

Agnese, R., Anderson, A. J., Balakishiyeva, D., Thakur, R. Basu, Bauer, D. A., Billard, J., Borgland, A., Bowles, M. A., Brandt, D., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Cerdeno, D. G., Chagani, H., Chen, Y., Cooley, J., Cornell, B., Crewdson, C. H., Cushman, P., Daal, M., Di Stefano, P. C. F., Doughty, T., Esteban, L., Fallows, S., Figueroa-Feliciano, E., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, H. R., Hertel, S. A., Hofer, T., Holmgren, D., Hsu, L., Huber, M. E., Jastram, A., Kamaev, O., Kara, B., Kelsey, M. H., Kennedy, A., Kiveni, M., Koch, K., Leder, A., Loer, B., Asamar, E. Lopez, Mahapatra, R., Mandic, V., Martinez, C., McCarthy, K. A., Mirabolfathi, N., Moffatt, R. A., Moore, D. C., Nelson, H., Nelson, R. H., Ogburn, R. W., Page, K., Page, W. A., Partridge, R., Pepin, M., Phipps, A., Prasad, K., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Ricci, Y., Rogers, H. E., Saab, T., Sadoulet, B., Sander, J., Schneck, K., Schnee, R. W., Scorza, S., Serfass, B., Shank, B., Speller, D., Upadhyayula, S., Villano, A. N., Welliver, B., Wright, D. H., Yellin, S., Yen, J. J., Young, B. A., and Zhang, J.

Subjects
High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Physics - Instrumentation and Detectors
Abstract

While the Standard Model of particle physics does not include free particles with fractional charge, experimental searches have not ruled out their existence. We report results from the Cryogenic Dark Matter Search (CDMS II) experiment that give the first direct-detection limits for cosmogenically-produced relativistic particles with electric charge lower than $e$/6. A search for tracks in the six stacked detectors of each of two of the CDMS II towers found no candidates, thereby excluding new parameter space for particles with electric charges between $e$/6 and $e$/200., Comment: 5 pages, 6 figures, submitted to PRL

Published
2014
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19. Measurement Of Quasiparticle Transport In Aluminum Films Using Tungsten Transition-Edge Sensors

Author

Yen, J. J., Shank, B., Young, B. A., Cabrera, B., Brink, P. L., Cherry, M., Kreikebaum, J. M, Moffatt, R., Redl, P., Tomada, A., and Tortorici, E. C.

Subjects
Physics - Instrumentation and Detectors
Abstract

We report new experimental studies to understand the physics of phonon sensors which utilize quasiparticle diffusion in thin aluminum films into tungsten transition-edge-sensors (TESs) operated at 35 mK. We show that basic TES physics and a simple physical model of the overlap region between the W and Al films in our devices enables us to accurately reproduce the experimentally observed pulse shapes from x-rays absorbed in the Al films. We further estimate quasiparticle loss in Al films using a simple diffusion equation approach., Comment: 5 pages, 6 figures, PRAL

Published
2014
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20. Nonlinear Optimal Filter Technique For Analyzing Energy Depositions In TES Sensors Driven Into Saturation

Author

Shank, B., Yen, J. J., Cabrera, B., Kreikebaum, J. M., Moffatt, R., Redl, P., Young, B. A., Brink, P. L., Cherry, M., and Tomada, A.

Subjects
Physics - Instrumentation and Detectors, Condensed Matter - Superconductivity
Abstract

We present a detailed thermal and electrical model of superconducting transition edge sensors (TESs) connected to quasiparticle (qp) traps, such as the W TESs connected to Al qp traps used for CDMS (Cryogenic Dark Matter Search) Ge and Si detectors. We show that this improved model, together with a straightforward time-domain optimal filter, can be used to analyze pulses well into the nonlinear saturation region and reconstruct absorbed energies with optimal energy resolution., Comment: companion paper to J. J. Yen's "Measurement Of Quasiparticle Transport In Aluminum Films Using Tungsten Transition-Edge Sensors"

Published
2014

21. Search for Low-Mass WIMPs with SuperCDMS

Author

Agnese, R., Anderson, A. J., Asai, M., Balakishiyeva, D., Thakur, R. Basu, Bauer, D. A., Beaty, J., Billard, J., Borgland, A., Bowles, M. A., Brandt, D., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Cerdeno, D. G., Chagani, H., Chen, Y., Cherry, M., Cooley, J., Cornell, B., Crewdson, C. H., Cushman, P., Daal, M., DeVaney, D., Di Stefano, P. C. F., Silva, E. Do Couto E, Doughty, T., Esteban, L., Fallows, S., Figueroa-Feliciano, E., Godfrey, G. L., Golwala, S. R., Hall, J., Hansen, S., Harris, H. R., Hertel, S. A., Hines, B. A., Hofer, T., Holmgren, D., Hsu, L., Huber, M. E., Jastram, A., Kamaev, O., Kara, B., Kelsey, M. H., Kenany, S., Kennedy, A., Kiveni, M., Koch, K., Leder, A., Loer, B., Asamar, E. Lopez, Mahapatra, R., Mandic, V., Martinez, C., McCarthy, K. A., Mirabolfathi, N., Moffatt, R. A., Nelson, R. H., Novak, L., Page, K., Partridge, R., Pepin, M., Phipps, A., Platt, M., Prasad, K., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Resch, R. W., Ricci, Y., Ruschman, M., Saab, T., Sadoulet, B., Sander, J., Schmitt, R. L., Schneck, K., Schnee, R. W., Scorza, S., Seitz, D. N., Serfass, B., Shank, B., Speller, D., Tomada, A., Upadhyayula, S., Villano, A. N., Welliver, B., Wright, D. H., Yellin, S., Yen, J. J., Young, B. A., and Zhang, J.

Subjects
High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Physics - Instrumentation and Detectors
Abstract

We report a first search for weakly interacting massive particles (WIMPs) using the background rejection capabilities of SuperCDMS. An exposure of 577 kg-days was analyzed for WIMPs with mass < 30 GeV/c2, with the signal region blinded. Eleven events were observed after unblinding. We set an upper limit on the spin-independent WIMP-nucleon cross section of 1.2e-42 cm2 at 8 GeV/c2. This result is in tension with WIMP interpretations of recent experiments and probes new parameter space for WIMP-nucleon scattering for WIMP masses < 6 GeV/c2., Comment: 6 pages, 4 figures; figure 1 updated, submitted to Phys. Rev. Lett

Published
2014
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22. CDMSlite: A Search for Low-Mass WIMPs using Voltage-Assisted Calorimetric Ionization Detection in the SuperCDMS Experiment

Author

Agnese, R., Anderson, A. J., Asai, M., Balakishiyeva, D., Thakur, R. Basu, Bauer, D. A., Billard, J., Borgland, A., Bowles, M. A., Brandt, D., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Cerdeno, D. G., Chagani, H., Cooley, J., Cornell, B., Crewdson, C. H., Cushman, P., Daal, M., Di Stefano, P. C. F., Doughty, T., Esteban, L., Fallows, S., Figueroa-Feliciano, E., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, H. R., Hertel, S. A., Hofer, T., Holmgren, D., Hsu, L., Huber, M. E., Jastram, A., Kamaev, O., Kara, B., Kelsey, M. H., Kennedy, A., Kiveni, M., Koch, K., Loer, B., Asamar, E. Lopez, Mahapatra, R., Mandic, V., Martinez, C., McCarthy, K. A., Mirabolfathi, N., Moffatt, R. A., Moore, D. C., Nadeau, P., Nelson, R. H., Page, K., Partridge, R., Pepin, M., Phipps, A., Prasad, K., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Ricci, Y., Saab, T., Sadoulet, B., Sander, J., Schneck, K., Schnee, R. W., Scorza, S., Serfass, B., Shank, B., Speller, D., Villano, A. N., Welliver, B., Wright, D. H., Yellin, S., Yen, J. J., Young, B. A., and Zhang, J.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Cosmology and Extragalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

SuperCDMS is an experiment designed to directly detect Weakly Interacting Massive Particles (WIMPs), a favored candidate for dark matter ubiquitous in the Universe. In this paper, we present WIMP-search results using a calorimetric technique we call CDMSlite, which relies on voltage- assisted Luke-Neganov amplification of the ionization energy deposited by particle interactions. The data were collected with a single 0.6 kg germanium detector running for 10 live days at the Soudan Underground Laboratory. A low energy threshold of 170 eVee (electron equivalent) was obtained, which allows us to constrain new WIMP-nucleon spin-independent parameter space for WIMP masses below 6 GeV/c2., Comment: 7 pages, 4 figures

Published
2013
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23. Demonstration of Surface Electron Rejection with Interleaved Germanium Detectors for Dark Matter Searches

Author

Agnese, R., Anderson, A. J., Balakishiyeva, D., Thakur, R. Basu, Bauer, D. A., Borgland, A., Brandt, D., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Cerdeno, D. G., Chagani, H., Cherry, M., Cooley, J., Cornell, B., Crewdson, C. H., Cushman, P., Daal, M., Di Stefano, P. C. F., Silva, E. Do Couto E, Doughty, T., Esteban, L., Fallows, S., Figueroa-Feliciano, E., Fox, J., Fritts, M., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, H. R., Hasi, J., Hertel, S. A., Hines, B. A., Hofer, T., Holmgren, D., Hsu, L., Huber, M. E., Jastram, A., Kamaev, O., Kara, B., Kelsey, M. H., Kenany, S. A., Kennedy, A., Kenney, C. J., Kiveni, M., Koch, K., Loer, B., Asamar, E. Lopez, Mahapatra, R., Mandic, V., Martinez, C., McCarthy, K. A., Mirabolfathi, N., Moffatt, R. A., Moore, D. C., Nadeau, P., Nelson, R. H., Novak, L., Page, K., Partridge, R., Pepin, M., Phipps, A., Prasad, K., Pyle, M., Qiu, H., Radpour, R., Rau, W., Redl, P., Reisetter, A., Resch, R. W., Ricci, Y., Saab, T., Sadoulet, B., Sander, J., Schmitt, R., Schneck, K., Schnee, R. W., Scorza, S., Seitz, D., Serfass, B., Shank, B., Speller, D., Tomada, A., Villano, A. N., Welliver, B., Wright, D. H., Yellin, S., Yen, J. J., Young, B. A., and Zhang, J.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Astrophysics of Galaxies, High Energy Physics - Experiment
Abstract

The SuperCDMS experiment in the Soudan Underground Laboratory searches for dark matter with a 9-kg array of cryogenic germanium detectors. Symmetric sensors on opposite sides measure both charge and phonons from each particle interaction, providing excellent discrimination between electron and nuclear recoils, and between surface and interior events. Surface event rejection capabilities were tested with two $^{210}$Pb sources producing $\sim$130 beta decays/hr. In $\sim$800 live hours, no events leaked into the 8--115 keV signal region, giving upper limit leakage fraction $1.7 \times 10^{-5}$ at 90% C.L., corresponding to $< 0.6$ surface event background in the future 200-kg SuperCDMS SNOLAB experiment., Comment: 5 pages, 4 figures, submitted to journal

Published
2013
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24. Silicon Detector Dark Matter Results from the Final Exposure of CDMS II

Author

CDMS Collaboration, Agnese, R., Ahmed, Z., Anderson, A. J., Arrenberg, S., Balakishiyeva, D., Thakur, R. Basu, Bauer, D. A., Billard, J., Borgland, A., Brandt, D., Brink, P. L., Bruch, T., Bunker, R., Cabrera, B., Caldwell, D. O., Cerdeno, D. G., Chagani, H., Cooley, J., Cornell, B., Crewdson, C. H., Cushman, P., Daal, M., Dejongh, F., Silva, E. Do Couto E, Doughty, T., Esteban, L., Fallows, S., Figueroa-Feliciano, E., Filippini, J., Fox, J., Fritts, M., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, R. H., Hertel, S. A., Hofer, T., Holmgren, D., Hsu, L., Huber, M. E., Jastram, A., Kamaev, O., Kara, B., Kelsey, M. H., Kennedy, A., Kim, P., Kiveni, M., Koch, K., Kos, M., Leman, S. W., Loer, B., Asamar, E. Lopez, Mahapatra, R., Mandic, V., Martinez, C., McCarthy, K. A., Mirabolfathi, N., Moffatt, R. A., Moore, D. C., Nadeau, P., Nelson, R. H., Page, K., Partridge, R., Pepin, M., Phipps, A., Prasad, K., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Ricci, Y., Saab, T., Sadoulet, B., Sander, J., Schneck, K., Schnee, R. W., Scorza, S., Serfass, B., Shank, B., Speller, D., Sundqvist, K. M., Villano, A. N., Welliver, B., Wright, D. H., Yellin, S., Yen, J. J., Yoo, J., Young, B. A., and Zhang, J.

Subjects
High Energy Physics - Experiment, Astrophysics - Cosmology and Extragalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

We report results of a search for Weakly Interacting Massive Particles (WIMPS) with the silicon detectors of the CDMS II experiment. This blind analysis of 140.2 kg-days of data taken between July 2007 and September 2008 revealed three WIMP-candidate events with a surface-event background estimate of 0.41^{+0.20}_{-0.08}(stat.)^{+0.28}_{-0.24}(syst.). Other known backgrounds from neutrons and 206Pb are limited to < 0.13 and <0.08 events at the 90% confidence level, respectively. The exposure of this analysis is equivalent to 23.4 kg-days for a recoil energy range of 7-100 keV for a WIMP of mass 10 GeV/c2. The probability that the known backgrounds would produce three or more events in the signal region is 5.4%. A profile likelihood ratio test of the three events that includes the measured recoil energies gives a 0.19% probability for the known-background-only hypothesis when tested against the alternative WIMP+background hypothesis. The highest likelihood occurs for a WIMP mass of 8.6 GeV/c2 and WIMP-nucleon cross section of 1.9e-41 cm2., Comment: 5 pages, 4 figures, as accepted by PRL

Published
2013

25. Silicon detector results from the first five-tower run of CDMS II

Author

CDMS Collaboration, Agnese, R., Ahmed, Z., Anderson, A. J., Arrenberg, S., Balakishiyeva, D., Thakur, R. Basu, Bauer, D. A., Borgland, A., Brandt, D., Brink, P. L., Bruch, T., Bunker, R., Cabrera, B., Caldwell, D. O., Cerdeno, D. G., Chagani, H., Cooley, J., Cornell, B., Crewdson, C. H., Cushman, P., Daal, M., Dejongh, F., Di Stefano, P. C. F., Silva, E. do Couto e, Doughty, T., Esteban, L., Fallows, S., Figueroa-Feliciano, E., Filippini, J., Fox, J., Fritts, M., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, R. H., Hertel, S. A., Hofer, T., Holmgren, D., Hsu, L., Huber, M. E., Jastram, A., Kamaev, O., Kara, B., Kelsey, M. H., Kennedy, A., Kim, P., Kiveni, M., Koch, K., Kos, M., Leman, S. W., Lopez-Asamar, E., Mahapatra, R., Mandic, V., Martinez, C., McCarthy, K. A., Mirabolfathi, N., Moffatt, R. A., Moore, D. C., Nadeau, P., Nelson, R. H., Page, K., Partridge, R., Pepin, M., Phipps, A., Prasad, K., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Ricci, Y., Saab, T., Sadoulet, B., Sander, J., Schneck, K., Schnee, R. W., Scorza, S., Serfass, B., Shank, B., Speller, D., Sundqvist, K. M., Villano, A. N., Welliver, B., Wright, D. H., Yellin, S., Yen, J. J., Yoo, J., Young, B. A., and Zhan, J.

Subjects
Astrophysics - Cosmology and Extragalactic Astrophysics, High Energy Physics - Experiment
Abstract

We report results of a search for Weakly Interacting Massive Particles (WIMPs) with the Si detectors of the CDMS II experiment. This report describes a blind analysis of the first data taken with CDMS II's full complement of detectors in 2006-2007; results from this exposure using the Ge detectors have already been presented. We observed no candidate WIMP-scattering events in an exposure of 55.9 kg-days before analysis cuts, with an expected background of ~1.1 events. The exposure of this analysis is equivalent to 10.3 kg-days over a recoil energy range of 7-100 keV for an ideal Si detector and a WIMP mass of 10 GeV/c2. These data set an upper limit of 1.7x10-41 cm2 on the WIMP-nucleon spin-independent cross section of a 10 GeV/c2 WIMP. These data exclude parameter space for spin-independent WIMP-nucleon elastic scattering that is relevant to recent searches for low-mass WIMPs., Comment: 5 pages, 4 figures; updated to match published version

Published
2013
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26. OC 30.5 Expression and Activity of Human Factor VIII (hFVIII) Following Single and Repeat Administration of an Integrating Non-Viral Gene Therapy in Multiple Mouse Models of Severe Hemophilia A

Author

Truong, B., primary, Hajj, K., additional, Nguyen, G., additional, Schwerk, J., additional, Tamayo, J., additional, Smith, D., additional, Goolyam, M., additional, Abernathy, D., additional, Lopez Espinoza, F., additional, Burrascano, M., additional, Yen, J., additional, Briseno, K., additional, Lucas, J., additional, Battiprolu, P., additional, Bennett, M., additional, Madison, B., additional, Sabatino, D., additional, Warner, B., additional, Ostertag, E., additional, and Rychak, J., additional

Published
2023
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27. PB0182 Development of a Non-Viral Gene Therapy Approach for Severe Bleeding Disorders

Author

Hajj, K., primary, Schwerk, J., additional, Lucas, J., additional, Truong, B., additional, Lee, S., additional, Briseno, K., additional, Yen, J., additional, Burrascano, M., additional, Smith, D., additional, Tamayo, J., additional, Lopez Espinoza, F., additional, Battiprolu, P., additional, Madison, B., additional, Warner, B., additional, Bennett, M., additional, and Rychak, J., additional

Published
2023
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29. A-093 Clinical Performance of Biomarkers for Traumatic Brain Injury

Author

Grasso, K B, primary, Yen, J L, additional, Rutkowski, A, additional, Ostro, R S, additional, Johnston, D R, additional, Buss, A C, additional, Datwyler, S A, additional, Marino, J, additional, Christenson, R H, additional, Zhu, Y, additional, deFilippi, C, additional, and Caudle, K L, additional

Published
2023
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43. Successful Treatment with Ensartinib After Alectinib-induced Hyperbilirubinemia in ALK-Positive NSCLC

Author

Peng L, Xiao K, Cui J, Ye XH, Zhang YC, Mao L, Selvaggi G, Yen J, and Stebbing J

Subjects
alk, hyperbilirubinemia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, alectinib, ensartinib, nsclc, RC254-282
Abstract

Ling Peng,1,* Kui Xiao,2,* Jian Cui,3 Xiang-Hua Ye,4 Yong-Chang Zhang,5 Li Mao,6 Giovanni Selvaggi,7 Jennifer Yen,8 Justin Stebbing9 1Department of Pulmonary and Critical Care Medicine, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang Province, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China; 3Shanghai BioGenius Bioinformatics Institute, Shanghai, People’s Republic of China; 4Department of Radiotherapy, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China; 5Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, Hunan, People’s Republic of China; 6Betta Pharmaceuticals, Hangzhou, People’s Republic of China; 7X-Covery Holdings, Palm Beach Gardens, FL, USA; 8Guardant Health, Inc., Redwood City, CA, USA; 9Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK*These authors contributed equally to this workCorrespondence: Ling PengDepartment of Pulmonary and Critical Care Medicine, Zhejiang Provincial People’s Hospital, No. 158 Shangtang Road, Hangzhou, Zhejiang Province, People’s Republic of ChinaTel/Fax +86-571-85893509Email drpengling@hotmai.comBackground: Alectinib is approved for the treatment of advanced non-small-cell lung cancer (NSCLC) harboring ALK rearrangements. Although generally well tolerated, alectinib can cause serious or life-threatening side effects.Case Presentation: Here, we report a case of a patient with NSCLC with an EML4-ALK fusion and was treated with alectinib but who developed grade 4 hyperbilirubinemia after five months on therapy. Alectinib was discontinued, and an artificial liver support system (ALSS) was used with an impressive decline in bilirubin levels. After two months drug-free, the patient experienced disease progression. Ensartinib was initiated as second-line treatment with a best response of stable disease after three months of therapy with no evidence of hyperbilirubinemia.Conclusion: This is the first report of ensartinib treatment after alectinib-induced hyperbilirubinemia which was successfully relieved by ALSS treatment and targeted drug cessation.Keywords: ensartinib, alectinib, hyperbilirubinemia, NSCLC, ALK

Published
2021

47. Volcanic Precursor Revealed by Machine Learning Offers New Eruption Forecasting Capability

Author

Kaiwen Wang, Felix Waldhauser, Maya Tolstoy, David Schaff, Theresa Sawi, William S. D. Wilcock, and Yen Joe Tan

Subjects
Geophysics. Cosmic physics, QC801-809
Abstract

Abstract Seismicity at active volcanoes provides crucial constraints on the dynamics of magma systems and complex fault activation processes preceding and during an eruption. We characterize time‐dependent spectral features of volcanic earthquakes at Axial Seamount with unsupervised machine learning (ML) methods, revealing mixed frequency signals that rapidly increase in number about 15 hr before eruption onset. The events migrate along pre‐existing fissures, suggesting that they represent brittle crack opening driven by influx of magma or volatiles. These results demonstrate the power of unsupervised ML algorithms to characterize subtle changes in magmatic processes associated with eruption preparation, offering new possibilities for forecasting Axial's anticipated next eruption. This analysis is generalizable and can be employed to identify similar precursory signals at other active volcanoes.

Published
2024
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