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An electrocardiogram (ECG) is a non-invasive and cost-effective method for diagnosing heart disease. However, physicians often face challenges in interpreting ECG. As a result, deep learning (DL) models have been proposed to assist with interpretation. However, the development of a robust, interpretable model that performs well across diverse ECG datasets remains a focus. Hence, this study presents a robust interpretable DL-based system. The model utilizes a multi-channel hybrid architecture. It integrates 12 blocks of one-dimensional convolutional neural network (CNN) with bidirectional long short-term memory (BiLSTM) networks, followed by an attention mechanism and a two-dimensional CNN, and finally fully connected (FC) layers for classification. The model separately trained and tested on three 12-lead ECG datasets: PTB-XL, CODE-15%, and the reduced seven and merged four classes of Chapman Arrhythmia datasets, achieved average test accuracy rates of 89.84%, 97.82%, 98.55%, and 98.80%, respectively.The result indicates the model’s effectiveness across different ECG datasets. Besides, the classification output is analyzed using two post-hoc model interpretability techniques: Gradient-weighted Class Activation Mapping Plus Plus (Grad-CAM++) and SHapley Additive exPlanations (SHAP). These techniques are applied to the trained model to visualize influential segments of the ECG signal, both at the instance level for specific samples and at the test set level to assess the contributions of individual ECG leads among the 12 leads that influence the model predictions. The model’s performance and its output interpretation techniques makes it a practicable tool in ECG-based heart disease diagnosis.

Pulmonary tuberculosis (PTB) is a bacterial infection that affects the lung. PTB remains one of the infectious diseases with the highest global mortalities. Chest radiography is a technique that is often employed in the diagnosis of PTB. Radiologists identify the severity and stage of PTB by inspecting radiographic features in the patient’s chest X-ray (CXR). The most common radiographic features seen on CXRs include cavitation, consolidation, masses, pleural effusion, calcification, and nodules. Identifying these CXR features will help physicians in diagnosing a patient. However, identifying these radiographic features for intricate disorders is challenging, and the accuracy depends on the radiologist’s experience and level of expertise. So, researchers have proposed deep learning (DL) techniques to detect and mark areas of tuberculosis infection in CXRs. DL models have been proposed in the literature because of their inherent capacity to detect diseases and segment the manifestation regions from medical images. However, fully supervised semantic segmentation requires several pixel-by-pixel labeled images. The annotation of such a large amount of data by trained physicians has some challenges. First, the annotation requires a significant amount of time. Second, the cost of hiring trained physicians is expensive. In addition, the subjectivity of medical data poses a difficulty in having standardized annotation. As a result, there is increasing interest in weak localization techniques. Therefore, in this review, we identify methods employed in the weakly supervised segmentation and localization of radiographic manifestations of pulmonary tuberculosis from chest X-rays. First, we identify the most commonly used public chest X-ray datasets for tuberculosis identification. Following that, we discuss the approaches for weakly localizing tuberculosis radiographic manifestations in chest X-rays. The weakly supervised localization of PTB can highlight the region of the chest X-ray image that contributed the most to the DL model’s classification output and help pinpoint the diseased area. Finally, we discuss the limitations and challenges of weakly supervised techniques in localizing TB manifestations regions in chest X-ray images.

Heart disease is one of the leading causes of mortality throughout the world. Among the different heart diagnosis techniques, an electrocardiogram (ECG) is the least expensive non-invasive procedure. However, the following are challenges: the scarcity of medical experts, the complexity of ECG interpretations, the manifestation similarities of heart disease in ECG signals, and heart disease comorbidity. Machine learning algorithms are viable alternatives to the traditional diagnoses of heart disease from ECG signals. However, the black box nature of complex machine learning algorithms and the difficulty in explaining a model’s outcomes are obstacles for medical practitioners in having confidence in machine learning models. This observation paves the way for interpretable machine learning (IML) models as diagnostic tools that can build a physician’s trust and provide evidence-based diagnoses. Therefore, in this systematic literature review, we studied and analyzed the research landscape in interpretable machine learning techniques by focusing on heart disease diagnosis from an ECG signal. In this regard, the contribution of our work is manifold; first, we present an elaborate discussion on interpretable machine learning techniques. In addition, we identify and characterize ECG signal recording datasets that are readily available for machine learning-based tasks. Furthermore, we identify the progress that has been achieved in ECG signal interpretation using IML techniques. Finally, we discuss the limitations and challenges of IML techniques in interpreting ECG signals.

Cereals are an important and major source of the human diet. They constitute more than two-thirds of the world’s food source and cover more than 56% of the world’s cultivatable land. These important sources of food are affected by a variety of damaging diseases, causing significant loss in annual production. In this regard, detection of diseases at an early stage and quantification of the severity has acquired the urgent attention of researchers worldwide. One emerging and popular approach for this task is the utilization of machine learning techniques. In this work, we have identified the most common and damaging diseases affecting cereal crop production, and we also reviewed 45 works performed on the detection and classification of various diseases that occur on six cereal crops within the past five years. In addition, we identified and summarised numerous publicly available datasets for each cereal crop, which the lack thereof we identified as the main challenges faced for researching the application of machine learning in cereal crop detection. In this survey, we identified deep convolutional neural networks trained on hyperspectral data as the most effective approach for early detection of diseases and transfer learning as the most commonly used and yielding the best result training method.

A brain Magnetic resonance imaging (MRI) scan of a single individual consists of several slices across the 3D anatomical view. Therefore, manual segmentation of brain tumors from magnetic resonance (MR) images is a challenging and time-consuming task. In addition, an automated brain tumor classification from an MRI scan is non-invasive so that it avoids biopsy and make the diagnosis process safer. Since the beginning of this millennia and late nineties, the effort of the research community to come-up with automatic brain tumor segmentation and classification method has been tremendous. As a result, there are ample literature on the area focusing on segmentation using region growing, traditional machine learning and deep learning methods. Similarly, a number of tasks have been performed in the area of brain tumor classification into their respective histological type, and an impressive performance results have been obtained. Considering state of-the-art methods and their performance, the purpose of this paper is to provide a comprehensive survey of three, recently proposed, major brain tumor segmentation and classification model techniques, namely, region growing, shallow machine learning and deep learning. The established works included in this survey also covers technical aspects such as the strengths and weaknesses of different approaches, pre- and post-processing techniques, feature extraction, datasets, and models’ performance evaluation metrics.