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5. Supplementary methods from Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling

Author

D'Agostino, Luca, primary, Nie, Yingchao, primary, Goswami, Sayantani, primary, Tong, Kevin, primary, Yu, Shiyan, primary, Bandyopadhyay, Sheila, primary, Flores, Juan, primary, Zhang, Xiao, primary, Balasubramanian, Iyshwarya, primary, Joseph, Ivor, primary, Sakamori, Ryotaro, primary, Farrell, Victoria, primary, Li, Qi, primary, Yang, Chung S., primary, Gao, Bin, primary, Ferraris, Ronaldo P., primary, Yehia, Ghassan, primary, Bonder, Edward M., primary, Goldenring, James R., primary, Verzi, Michael P., primary, Zhang, Lanjing, primary, Ip, Y. Tony, primary, and Gao, Nan, primary

Published
2023
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6. Supplementary Figure 6 from Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling

Author

D'Agostino, Luca, primary, Nie, Yingchao, primary, Goswami, Sayantani, primary, Tong, Kevin, primary, Yu, Shiyan, primary, Bandyopadhyay, Sheila, primary, Flores, Juan, primary, Zhang, Xiao, primary, Balasubramanian, Iyshwarya, primary, Joseph, Ivor, primary, Sakamori, Ryotaro, primary, Farrell, Victoria, primary, Li, Qi, primary, Yang, Chung S., primary, Gao, Bin, primary, Ferraris, Ronaldo P., primary, Yehia, Ghassan, primary, Bonder, Edward M., primary, Goldenring, James R., primary, Verzi, Michael P., primary, Zhang, Lanjing, primary, Ip, Y. Tony, primary, and Gao, Nan, primary

Published
2023
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7. Data from Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling

Author

D'Agostino, Luca, primary, Nie, Yingchao, primary, Goswami, Sayantani, primary, Tong, Kevin, primary, Yu, Shiyan, primary, Bandyopadhyay, Sheila, primary, Flores, Juan, primary, Zhang, Xiao, primary, Balasubramanian, Iyshwarya, primary, Joseph, Ivor, primary, Sakamori, Ryotaro, primary, Farrell, Victoria, primary, Li, Qi, primary, Yang, Chung S., primary, Gao, Bin, primary, Ferraris, Ronaldo P., primary, Yehia, Ghassan, primary, Bonder, Edward M., primary, Goldenring, James R., primary, Verzi, Michael P., primary, Zhang, Lanjing, primary, Ip, Y. Tony, primary, and Gao, Nan, primary

Published
2023
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8. Supplementary Figure 5 from Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling

Author

D'Agostino, Luca, primary, Nie, Yingchao, primary, Goswami, Sayantani, primary, Tong, Kevin, primary, Yu, Shiyan, primary, Bandyopadhyay, Sheila, primary, Flores, Juan, primary, Zhang, Xiao, primary, Balasubramanian, Iyshwarya, primary, Joseph, Ivor, primary, Sakamori, Ryotaro, primary, Farrell, Victoria, primary, Li, Qi, primary, Yang, Chung S., primary, Gao, Bin, primary, Ferraris, Ronaldo P., primary, Yehia, Ghassan, primary, Bonder, Edward M., primary, Goldenring, James R., primary, Verzi, Michael P., primary, Zhang, Lanjing, primary, Ip, Y. Tony, primary, and Gao, Nan, primary

Published
2023
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9. Key resources table from Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling

Author

D'Agostino, Luca, primary, Nie, Yingchao, primary, Goswami, Sayantani, primary, Tong, Kevin, primary, Yu, Shiyan, primary, Bandyopadhyay, Sheila, primary, Flores, Juan, primary, Zhang, Xiao, primary, Balasubramanian, Iyshwarya, primary, Joseph, Ivor, primary, Sakamori, Ryotaro, primary, Farrell, Victoria, primary, Li, Qi, primary, Yang, Chung S., primary, Gao, Bin, primary, Ferraris, Ronaldo P., primary, Yehia, Ghassan, primary, Bonder, Edward M., primary, Goldenring, James R., primary, Verzi, Michael P., primary, Zhang, Lanjing, primary, Ip, Y. Tony, primary, and Gao, Nan, primary

Published
2023
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10. Supplementary Figure 3 from Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling

Author

D'Agostino, Luca, primary, Nie, Yingchao, primary, Goswami, Sayantani, primary, Tong, Kevin, primary, Yu, Shiyan, primary, Bandyopadhyay, Sheila, primary, Flores, Juan, primary, Zhang, Xiao, primary, Balasubramanian, Iyshwarya, primary, Joseph, Ivor, primary, Sakamori, Ryotaro, primary, Farrell, Victoria, primary, Li, Qi, primary, Yang, Chung S., primary, Gao, Bin, primary, Ferraris, Ronaldo P., primary, Yehia, Ghassan, primary, Bonder, Edward M., primary, Goldenring, James R., primary, Verzi, Michael P., primary, Zhang, Lanjing, primary, Ip, Y. Tony, primary, and Gao, Nan, primary

Published
2023
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11. Supplementary Figure 2 from Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling

Author

D'Agostino, Luca, primary, Nie, Yingchao, primary, Goswami, Sayantani, primary, Tong, Kevin, primary, Yu, Shiyan, primary, Bandyopadhyay, Sheila, primary, Flores, Juan, primary, Zhang, Xiao, primary, Balasubramanian, Iyshwarya, primary, Joseph, Ivor, primary, Sakamori, Ryotaro, primary, Farrell, Victoria, primary, Li, Qi, primary, Yang, Chung S., primary, Gao, Bin, primary, Ferraris, Ronaldo P., primary, Yehia, Ghassan, primary, Bonder, Edward M., primary, Goldenring, James R., primary, Verzi, Michael P., primary, Zhang, Lanjing, primary, Ip, Y. Tony, primary, and Gao, Nan, primary

Published
2023
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12. Supplementary Figure 4 from Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling

Author

D'Agostino, Luca, primary, Nie, Yingchao, primary, Goswami, Sayantani, primary, Tong, Kevin, primary, Yu, Shiyan, primary, Bandyopadhyay, Sheila, primary, Flores, Juan, primary, Zhang, Xiao, primary, Balasubramanian, Iyshwarya, primary, Joseph, Ivor, primary, Sakamori, Ryotaro, primary, Farrell, Victoria, primary, Li, Qi, primary, Yang, Chung S., primary, Gao, Bin, primary, Ferraris, Ronaldo P., primary, Yehia, Ghassan, primary, Bonder, Edward M., primary, Goldenring, James R., primary, Verzi, Michael P., primary, Zhang, Lanjing, primary, Ip, Y. Tony, primary, and Gao, Nan, primary

Published
2023
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13. Supplementary Figure 1 from Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling

Author

D'Agostino, Luca, primary, Nie, Yingchao, primary, Goswami, Sayantani, primary, Tong, Kevin, primary, Yu, Shiyan, primary, Bandyopadhyay, Sheila, primary, Flores, Juan, primary, Zhang, Xiao, primary, Balasubramanian, Iyshwarya, primary, Joseph, Ivor, primary, Sakamori, Ryotaro, primary, Farrell, Victoria, primary, Li, Qi, primary, Yang, Chung S., primary, Gao, Bin, primary, Ferraris, Ronaldo P., primary, Yehia, Ghassan, primary, Bonder, Edward M., primary, Goldenring, James R., primary, Verzi, Michael P., primary, Zhang, Lanjing, primary, Ip, Y. Tony, primary, and Gao, Nan, primary

Published
2023
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16. Development of a Novel Human CD147 Knock-in NSG Mouse Model to Test SARS-CoV-2 Viral Infection

Author

Badeti, Saiaditya, primary, Jiang, Qingkui, additional, Naghizadeh, Alireza, additional, Tseng, Hsiang-chi, additional, Bushkin, Yuri, additional, Marras, Salvatore A.E., additional, Nisa, Annuurun, additional, Tyagi, Sanjay, additional, Chen, Fei, additional, Romanienko, Peter, additional, Yehia, Ghassan, additional, Evans, Deborah, additional, Lopez-Gonzalez, Moises, additional, Alland, David, additional, Russo, Riccardo, additional, Gause, William, additional, Shi, Lanbo, additional, and Liu, Dongfang, additional

Published
2022
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17. Additional file 1 of Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection

Author

Badeti, Saiaditya, Jiang, Qingkui, Naghizadeh, Alireza, Tseng, Hsiang-chi, Bushkin, Yuri, Marras, Salvatore A. E., Nisa, Annuurun, Tyagi, Sanjay, Chen, Fei, Romanienko, Peter, Yehia, Ghassan, Evans, Deborah, Lopez-Gonzalez, Moises, Alland, David, Russo, Riccardo, Gause, William, Shi, Lanbo, and Liu, Dongfang

Abstract

Additional file 1: Figure S1. Similar distribution of transgenic hCD147 protein by immunohistochemistry in various tissues in hCD147KIhet-NSG mice relative to WT-NSG mice. Tissues from wild-type NSG mice (left) were stained for mouse CD147 protein using rabbit anti-mouse primary antibody (R&D Systems, BAF772; 1:100) and tissues from hCD147KIhet-NSG mice (right) were stained for human CD147 protein using mouse anti-human primary antibody (HIM6; 1:500). Images were taken using an Olympus Inverted Light Microscope. Scale bar represents 100 µm. Figure S2. Specificity of anti-human CD147 and anti-mouse CD147 antibodies tested against human and mouse cell lines. Representative contour plots of CD147 expression on BNL 1ME A.7R.1 (top) and HepG2 (bottom) cells using antibodies targeting either mouse CD147 protein, human CD147 protein, or a combination of both antibodies (far right). Relative percentages are listed, and significant shifts highlighted in red. Gating was determined based on donkey anti-goat and mouse isotype IgG antibody background staining. Figure S3. Reduction of body weight 2 days post-infection in SARS-CoV-2 infected hACE2KI-NSG and K18-hACE2-B6 mice, and slight body weight reduction in infected hCD147KI-NSG mice. Average body weight loss as a percent of original body weight in WT-NSG (n=3), hCD147KI-NSG (n=3), hACE2KI-NSG (n=4), and K18-hACE2-B6 (n=3) mice following intranasal infection with the TCID50 dose of SARS-CoV-2 virus (1×105 PFU in 25ul per nostril). Error bars represent standard error measure (SEM). Statistical significance was determined using an unpaired one-tailed Student t test. *indicates significance of p

Published
2022
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18. Dopamine mediates vagal modulation of the immune system by electroacupuncture

Author

Torres-Rosas, Rafael, Yehia, Ghassan, Pena, Geber, Mishra, Priya, Thompson-Bonilla, Mariadel Rocio, Moreno-Eutimio, Mario Adan, Arriaga-Pizano, Lourdes Andrea, Isibasi, Armando, and Ulloa, Luis

Subjects
Electroacupuncture -- Physiological aspects -- Genetic aspects -- Research, Dopamine -- Physiological aspects -- Genetic aspects -- Research, Peritonitis -- Genetic aspects -- Care and treatment, Biological sciences, Health
Abstract

Previous anti-inflammatory strategies against sepsis, a leading cause of death in hospitals, had limited efficacy in clinical trials, in part because they targeted single cytokines and the experimental models failed to mimic clinical settings (1-3). Neuronal networks represent physiological mechanisms, selected by evolution to control inflammation, that can be exploited for the treatment of inflammatory and infectious disorders (3). Here, we report that sciatic nerve activation with electroacupuncture controls systemic inflammation and rescues mice from polymicrobial peritonitis. Electroacupuncture at the sciatic nerve controls systemic inflammation by inducing vagal activation of aromatic L-amino acid decarboxylase, leading to the production of dopamine in the adrenal medulla. Experimental models with adrenolectomized mice mimic clinical adrenal insufficiency (4), increase the susceptibility to sepsis and prevent the anti-inflammatory effects of electroacupuncture. Dopamine inhibits cytokine production via dopamine type 1 (D1) receptors. D1 receptor agonists suppress systemic inflammation and rescue mice with adrenal insufficiency from polymicrobial peritonitis. Our results suggest a new anti-inflammatory mechanism mediated by the sciatic and vagus nerves that modulates the production of catecholamines in the adrenal glands. From a pharmacological perspective, the effects of selective dopamine agonists mimic the anti-inflammatory effects of electroacupuncture and can provide therapeutic advantages to control inflammation in infectious and inflammatory disorders., Sepsis is the leading cause of mortality in noncoronary intensive care units, killing over 250,000 patients annually and accounting for 9.3% of overall deaths in the United States (1-3). Infection, [...]

Published
2014
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19. Specific N-cadherin–dependent pathways drive human breast cancer dormancy in bone marrow

Author

Sinha, Garima, primary, Ferrer, Alejandra I, additional, Ayer, Seda, additional, El-Far, Markos H, additional, Pamarthi, Sri Harika, additional, Naaldijk, Yahaira, additional, Barak, Pradeep, additional, Sandiford, Oleta A, additional, Bibber, Bernadette M, additional, Yehia, Ghassan, additional, Greco, Steven J, additional, Jiang, Jie-Gen, additional, Bryan, Margarette, additional, Kumar, Rakesh, additional, Ponzio, Nicholas M, additional, Etchegaray, Jean-Pierre, additional, and Rameshwar, Pranela, additional

Published
2021
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22. Neuroimmune/Hematopoietic Axis with Distinct Regulation by the High-Mobility Group Box 1 in Association with Tachykinin Peptides

Author

Gergues, Marina, primary, Nagula, Vipul, additional, Bliss, Sarah A., additional, Eljarrah, Adam, additional, Ayer, Seda, additional, Gnanavel, Nikhil, additional, Sinha, Garima, additional, Wu, Qunfeng, additional, Yehia, Ghassan, additional, Greco, Steven J., additional, Qian, Jing, additional, and Rameshwar, Pranela, additional

Published
2020
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23. Specific N-Cadherin-Dependent Pathways Drive Human Breast Cancer Dormancy in Bone Marrow

Author

Sinha, Garima, primary, Ferrer, Alejandra, additional, Ayer, Seda, additional, El-Far, Markos, additional, Parmarthi, Sri Harika, additional, Naaldijk, Yahaira, additional, Barak, Pradeep, additional, Sandiford, Oleta, additional, Bibber, Bernadette, additional, Yehia, Ghassan, additional, Greco, Steven, additional, Jiang, Jie-Gen, additional, Bryan, Margarette, additional, Kumar, Rakesh, additional, Ponzio, Nicholas, additional, Etchegaray, Jean-Pierre, additional, and Rameshwar, Pranela, additional

Published
2020
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28. Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling

Author

D'Agostino, Luca, primary, Nie, Yingchao, additional, Goswami, Sayantani, additional, Tong, Kevin, additional, Yu, Shiyan, additional, Bandyopadhyay, Sheila, additional, Flores, Juan, additional, Zhang, Xiao, additional, Balasubramanian, Iyshwarya, additional, Joseph, Ivor, additional, Sakamori, Ryotaro, additional, Farrell, Victoria, additional, Li, Qi, additional, Yang, Chung S., additional, Gao, Bin, additional, Ferraris, Ronaldo P., additional, Yehia, Ghassan, additional, Bonder, Edward M., additional, Goldenring, James R., additional, Verzi, Michael P., additional, Zhang, Lanjing, additional, Ip, Y. Tony, additional, and Gao, Nan, additional

Published
2019
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30. Additional file 1: Figure S1. of Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional control

Author

Wencheng Li, Park, Ji, Dinghai Zheng, Mainul Hoque, Yehia, Ghassan, and Tian, Bin

Abstract

Gene expression changes of proliferation genes and C/P-related genes. Figure S2. Analysis of cis elements around pAs of shortened 3’UTRs. Figure S3. ChIP-seq data for RNAPII and H3K4me3 in spermatids and spermatocytes. Figure S4. 3’UTR cis elements contribute to APA profiles in spermatogenesis. Figure S5. The effect of 3’UTR TEs on gene expression is independent of U-rich elements. Figure S6. Features of the introns containing regulated pAs. Figure S7. Transcript expression changes from 2 weeks to 4 weeks. Table S1. Top five more significant Ingenuity Canonical Pathways enriched for genes with shortened 3’UTRs as determined by the Ingenuity Pathway Analysis. Table S2. Statistics of 3’READS data. (PDF 625 kb)

Published
2016
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32. Small Fractions of Muscular Dystrophy Embryonic Stem Cells Yield Severe Cardiac and Skeletal Muscle Defects in Adult Mouse Chimeras

Author

Gonzalez, J. Patrick, primary, Kyrychenko, Sergii, additional, Kyrychenko, Viktoriia, additional, Schneider, Joel S., additional, Granier, Celine J., additional, Himelman, Eric, additional, Lahey, Kevin C., additional, Zhao, Qingshi, additional, Yehia, Ghassan, additional, Tao, Yuan-Xiang, additional, Bhaumik, Mantu, additional, Shirokova, Natalia, additional, and Fraidenraich, Diego, additional

Published
2016
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36. Blastocyst Injection of Wild Type Embryonic Stem Cells Induces Global Corrections in Mdx Mice

Author

Stillwell, Elizabeth, Vitale, Joseph, Zhao, Qingshi, Beck, Amanda, Schneider, Joel S., Khadim, Farah, Elson, Genie, Altaf, Aneela, Yehia, Ghassan, Dong, Jia-hui, Liu, Jing, Mark, Willie, Bhaumik, Mantu, Grange, Robert W., Fraidenraich, Diego, and Human Nutrition, Foods, and Exercise

Subjects
musculoskeletal diseases, congenital, hereditary, and neonatal diseases and abnormalities, embryonic structures, musculoskeletal system, reproductive and urinary physiology
Abstract

Duchenne muscular dystrophy (DMD) is an incurable neuromuscular degenerative disease, caused by a mutation in the dystrophin gene. Mdx mice recapitulate DMD features. Here we show that injection of wild-type (WT) embryonic stem cells (ESCs) into mdx blastocysts produces mice with improved pathology and function. A small fraction of WT ESCs incorporates into the mdx mouse nonuniformly to upregulate protein levels of dystrophin in the skeletal muscle. The chimeric muscle shows reduced regeneration and restores dystrobrevin, a dystrophin-related protein, in areas with high and with low dystrophin content. WT ESC injection increases the amount of fat in the chimeras to reach WT levels. ESC injection without dystrophin does not prevent the appearance of phenotypes in the skeletal muscle or in the fat. Thus, dystrophin supplied by the ESCs reverses disease in mdx mice globally in a dose-dependent manner. Published version

Published
2009

37. Small Fractions of Muscular Dystrophy Embryonic Stem Cells Yield Severe Cardiac and Skeletal Muscle Defects in Adult Mouse Chimeras.

Author

Gonzalez, J. Patrick, Kyrychenko, Sergii, Kyrychenko, Viktoriia, Schneider, Joel S., Granier, Celine J., Himelman, Eric, Lahey, Kevin C., Zhao, Qingshi, Yehia, Ghassan, Tao, Yuan-Xiang, Bhaumik, Mantu, Shirokova, Natalia, and Fraidenraich, Diego

Abstract

Duchenne muscular dystrophy (DMD) is characterized by the loss of the protein dystrophin, leading to muscle fragility, progressive weakening, and susceptibility to mechanical stress. Although dystrophin-negative mdx mouse models have classically been used to study DMD, phenotypes appear mild compared to patients. As a result, characterization of muscle pathology, especially in the heart, has proven difficult. We report that injection of mdx embryonic stem cells (ESCs) into Wild Type blastocysts produces adult mouse chimeras with severe DMD phenotypes in the heart and skeletal muscle. Inflammation, regeneration and fibrosis are observed at the whole organ level, both in dystrophin-negative and dystrophin-positive portions of the chimeric tissues. Skeletal and cardiac muscle function are also decreased to mdx levels. In contrast to mdx heterozygous carriers, which show no significant phenotypes, these effects are even observed in chimeras with low levels of mdx ESC incorporation (10%-30%). Chimeric mice lack typical compensatory utrophin upregulation, and show pathological remodeling of Connexin-43. In addition, dystrophin-negative and dystrophin-positive isolated cardiomyocytes show augmented calcium response to mechanical stress, similar to mdx cells. These global effects highlight a novel role of mdx ESCs in triggering muscular dystrophy even when only low amounts are present. S tem C ells 2017;35:597-610 [ABSTRACT FROM AUTHOR]

Published
2017
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38. Transgenic Expression of the Vitamin D Receptor Restricted to the Ileum, Cecum, and Colon of Vitamin D Receptor Knockout Mice Rescues Vitamin D Receptor-Dependent Rickets.

Author

Dhawan, Puneet, Veldurthy, Vaishali, Yehia, Ghassan, Hsaio, Connie, Porta, Angela, Kim, Ki-In, Patel, Nishant, Lieben, Liesbet, Verlinden, Lieve, Carmeliet, Geert, and Christakos, Sylvia

Abstract

Although the intestine plays the major role in 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] action on calcium homeostasis, the mechanisms involved remain incompletely understood. The established model of 1,25(OH)2D3-regulated intestinal calcium absorption postulates a critical role for the duodenum. However, the distal intestine is where 70% to 80% of ingested calcium is absorbed. To test directly the role of 1,25(OH)2D3 and the vitamin D receptor (VDR) in the distal intestine, three independent knockout (KO)/transgenic (TG) lines expressing VDR exclusively in the ileum, cecum, and colon were generated by breeding VDR KO mice with TG mice expressing human VDR (hVDR) under the control of the 9.5-kb caudal type homeobox 2 promoter. Mice from one TG line (KO/TG3) showed low VDR expression in the distal intestine (<50% of the levels observed in KO/TG1, KO/TG2, and wild-type mice). In the KO/TG mice, hVDR was not expressed in the duodenum, jejunum, kidney, or other tissues. Growth arrest, elevated parathyroid hormone level, and hypocalcemia of the VDR KO mice were prevented in mice from KO/TG lines 1 and 2. Microcomputed tomography analysis revealed that the expression of hVDR in the distal intestine of KO/TG1 and KO/TG2 mice rescued the bone defects associated with systemic VDR deficiency, including growth plate abnormalities and altered trabecular and cortical parameters. KO/TG3 mice showed rickets, but less severely than VDR KO mice. These findings show that expression of VDR exclusively in the distal intestine can prevent abnormalities in calcium homeostasis and bone mineralization associated with systemic VDR deficiency.

Published
2017
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43. Blastocyst Injection of Wild Type Embryonic Stem Cells Induces Global Corrections in Mdx Mice

Author

Stillwell, Elizabeth, primary, Vitale, Joseph, additional, Zhao, Qingshi, additional, Beck, Amanda, additional, Schneider, Joel, additional, Khadim, Farah, additional, Elson, Genie, additional, Altaf, Aneela, additional, Yehia, Ghassan, additional, Dong, Jia-hui, additional, Liu, Jing, additional, Mark, Willie, additional, Bhaumik, Mantu, additional, Grange, Robert, additional, and Fraidenraich, Diego, additional

Published
2009
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44. Global Ablation of the Mouse Rab11a Gene Impairs Early Embryogenesis and Matrix Metalloproteinase Secretion.

Author

Shiyan Yu, Yehia, Ghassan, Juanfei Wang, Stypulkowski, Ewa, Ryotaro Sakamori, Ping Jiang, Hernandez-Enriquez, Berenice, Tran, Tracy S., Bonder, Edward M., Wei Guo, and Nan Gao

Subjects
*MICE, *GENES, *GENOMES, *EMBRYOLOGY, *MATRIX metalloproteinases
Abstract

Rab11a has been conceived as a prominent regulatory component of the recycling endosome, which acts as a nexus in the endo- and exocytotic networks. The precise in vivo role of Rab11a in mouse embryonic development is unknown. We globally ablated Rab11a and examined the phenotypic and molecular outcomes in Rab11anull blastocysts and mouse embryonic fibroblasts. Using multiple trafficking assays and complementation analyses, we determined, among multiple important membrane-associated and soluble cargos, the critical contribution of Rab11a vesicular traffic to the secretion of multiple soluble MMPs. Rab11anull embryos were able to properly form normal blastocysts but died at peri-implantation stages. Our data suggest that Rab11a critically controls mouse blastocyst development and soluble matrix metalloproteinase secretion. [ABSTRACT FROM AUTHOR]

Published
2014
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