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15 results on '"Ye, Weisheng"'

1. Application of VMD-Based Electromagnetic Railgun Launch Current Feature Extraction in the Measurement of Muzzle-Leaving Time

Author

Chen, Yi, Yan, Jie, Huang, Kai, Ye, Weisheng, Li, Juxiang, Wang, Yi, Wang, Sui, Liu, Chengdong, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Dong, Xuzhu, editor, Yang, Qingxin, editor, and Ma, Weiming, editor

Published
2023
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4. Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants.

Author

Fang, Qizhi, Mok, Pamela Y, Thomas, Anila E, Haddad, Daniel J, Saini, Shereen A, Clifford, Brian T, Kapasi, Neel K, Danforth, Olivia M, Usui, Minako, Ye, Weisheng, Luu, Emmy, Sharma, Rikki, Bartel, Maya J, Pathmanabhan, Jeremy A, Ang, Andrew AS, Sievers, Richard E, Lee, Randall J, and Springer, Matthew L

Subjects
Pleiotrophin, Myoblasts, Angiogenesis, Endothelial cells, Hindlimb ischemia
Abstract

Pleiotrophin (PTN) is a growth factor with both pro-angiogenic and limited pro-tumorigenic activity. We evaluated the potential for PTN to be used for safe angiogenic gene therapy using the full length gene and a truncated gene variant lacking the domain implicated in tumorigenesis. Mouse myoblasts were transduced to express full length or truncated PTN (PTN or T-PTN), along with a LacZ reporter gene, and injected into mouse limb muscle and myocardium. In cultured myoblasts, PTN was expressed and secreted via the Golgi apparatus, but T-PTN was not properly secreted. Nonetheless, no evidence of uncontrolled growth was observed in cells expressing either form of PTN. PTN gene delivery to myocardium, and non-ischemic skeletal muscle, did not result in a detectable change in vascularity or function. In ischemic hindlimb at 14 days post-implantation, intramuscular injection with PTN-expressing myoblasts led to a significant increase in skin perfusion and muscle arteriole density. We conclude that (1) delivery of the full length PTN gene to muscle can be accomplished without tumorigenesis, (2) the truncated PTN gene may be difficult to use in a gene therapy context due to inefficient secretion, (3) PTN gene delivery leads to functional benefit in the mouse acute ischemic hindlimb model.

Published
2013

11. Compound Bacillusimproves eggshell quality and egg metabolites of hens by promoting the metabolism balance of calcium and phosphorus and uterine cell proliferation

Author

Jin, Qian, Wang, Fei, Ye, Weisheng, Wang, Qi, Xu, Shujie, Jiang, Shaoxiong, Li, Xiang, Yue, Min, Yu, Dongyou, Jin, Mingliang, Fu, Aikun, and Li, Weifen

Abstract

Probiotics have beneficial effects on improving egg quality, but there is little research about the effect of probiotics on metabolite composition, and the mechanisms are not yet fully understood. The aim of this study was to investigate the potential mechanisms by which compound Bacillusimproves egg quality and metabolite composition. A total of 20,000 Jingfen No. 6 laying hens at 381 d old were randomly divided into two treatments: control group with a basal diet, and the basal diet with compound Bacillussupplementation (Ba) group. The trial lasted eight weeks. The results showed that compound Bacillusimproved the gloss and strength of eggshells and reduced the ratio of sand-shell eggs by 23.8%. Specifically, the effective layer of eggshell was thicker and its calcite column was closely connected. Compound Bacillusincreased the contents of beneficial fatty acids in the egg yolk, and lipids and lipid-like molecules in the albumen (P< 0.01), while decreased the contents of total cholesterol, triglycerides, and benzene ring compounds in the egg yolk and organic oxygen compounds in the albumen (P< 0.01). In addition, the compound Bacillusincreased the calcium absorption in the duodenum by up-regulating the expression of transporters and serum hormone synergism (P< 0.05), and promoted metabolic balance of calcium and phosphorus. Simultaneously, uterine transcriptome showed that the expression of ChaC glutathione specific gamma-glutamylcyclotransferase 1 (CHAC1),glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1), phosphatidylinositol-4-phosphate 5-kinase type 1 beta (PIP5K1B), methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), brain enriched myelin associated protein 1 (BCAS1), and squalene epoxidase (SQLE)genes were increased (P< 0.01), indicating that nutrient metabolism activity was enhanced. The expression of the BCAS1, C1GALT1,KLF transcription factor 13 (KLF13),and leucine rich repeat neuronal 1 (LRRN1) was increased (P< 0.01), indicating that the cell proliferation was enhanced, which slowed uterus aging. In conclusion, compound Bacillusimproved the eggshell strength and metabolite composition in the egg by promoting metabolic balance of calcium and phosphorus, cell proliferation, and nutrient metabolism in the uterus.

Published
2024
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