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1. A Series of (Net) Spin-down Glitches in PSR J1522-5735: Insights from the Vortex Creep and Vortex Bending Models

Author

Zhou, S. Q., Ye, W. T., Ge, M. Y., GügercinoğLu, E., Zheng, S. J., Yu, C., Yuan, J. P., and Zhang, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Through a detailed timing analysis of $\textit{Fermi}$-LAT data, the rotational behavior of the $\gamma$-ray pulsar PSR J1522$-$5735 was tracked from August 2008 (MJD 54692) to January 2024 (MJD 60320). During this 15.4-year period, two over-recovery glitches and four anti-glitches were identified, marking a rare occurrence in rotation-powered pulsars (RPPs). The magnitudes of these (net) spin-down glitches were determined to be $|\Delta\nu_{\rm g}/\nu| \sim 10^{-8}$, well above the estimated detectability limit. For the two over-recovery glitches, the respective recovery fractions $Q$ are $2.1(7)$ and $1.4(2)$. Further analysis showed no substantial variations in either the flux or pulse profile shape in any of these events, suggesting that small (net) spin-down glitches, unlike large events observed in magnetars and magnetar-like RPPs, may occur without leaving an impact on the magnetosphere. Within the framework of the vortex creep and vortex bending models, anti-glitches and over-recoveries indicate the recoupling of vortex lines that moved inward as a result of a crustquake; meanwhile, the apparent fluctuations in the spin-down rate after the glitches occur as a result of the coupling of the oscillations of bent vortex lines to the magnetosphere., Comment: 8 pages, 3 figures, 2 tables, submitted to ApJL. Comments Welcome!

Published
2024

2. Broadband noise and quasi-periodic oscillation characteristics of the X-ray pulsar RX J0440.9+4431

Author

Li, P. P., Tao, L., Ma, R. C., Ge, M. Y., Zhao, Q. C., Zhao, S. J., Zhang, L., Bu, Q. C., Kong, L. D., Tuo, Y. L., Ji, L., Zhang, S., Qu, J. L., Zhang, S. N., Huang, Y., Ma, X., Ye, W. T., and Shui, Q. C.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract

We present a comprehensive timing analysis on the Be/X-ray binary pulsar RX J0440.9+4431 using observations from \textit{NICER} and \textit{Insight}-HXMT during the 2022--2023 outburst. The power density spectrum (PDS) of RX J0440.9+4431 exhibits typical aperiodic variability in X-ray flux across a wide frequency range. During a super-critical accretion state, we detect quasi-periodic oscillations (QPOs) at 0.2--0.5\,Hz in the light curves of five pulses for RX J0440.9+4431. The observed QPOs manifest during flares, while the flares appear at the peaks of the pulse profiles on a timescale of seconds and are primarily caused by an increase in hard photons. These flares can be explained by increased material ingestion in the accretion column at a fixed phase, primarily generating hard photons. Alternatively, an increase in accretion rate, independent of phase, may result in highly beamed hard photons within the accretion column, causing the flares. We argue the origin of QPOs to instabilities within the accretion flow. Additionally, we find that the break frequencies in the noise power spectra align well with $\propto L_{\mathrm{x}}^{3 / 7}$ across three orders of magnitude in the luminosity, which points to a relatively strong magnetic field in RX J0440.9+4431, estimated to be \textasciitilde$10^{13}$\,G., Comment: 8 pages, 7 figures. Accepted in MNRAS

Published
2024

3. Pulsed Iron line Emission from the First Galactic Ultraluminous X-ray Pulsar Swift J0243.6+6124

Author

Xiao, Y. X., Xu, Y. J., Ge, M. Y., Lu, F. J., Zhang, S. N., Zhang, S., Tao, L., Qu, J. L., Wang, P. J., Kong, L. D., Tuo, Y. L., You, Y., Zhao, S. J., Peng, J. Q., Du, Y. F., Zhang, Y. H., and Ye, W. T.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report the phase-resolved spectral results of the first Galactic Pulsating Ultra-Luminous X-ray source (PULX) Swift J0243.6+6124, modeling at its 2017-2018 outburst peak using data collected by the Hard X-ray Modulation Telescope (Insight-HXMT). The broad energy coverage of Insight-HXMT allows us to obtain more accurate spectral continuum to reduce the coupling of broad iron line profiles with other components. We use three different continuum spectrum models but obtain similar iron line results. For the first time, we detected the pulse characteristics of the broad iron line in a PULX. The variation in width and intensity of this iron line with $\sigma \sim 1.2-1.5$\,keV has a phase offset of about 0.25 from the pulse phase. We suggest that the uneven irradiation of the thick inner disk by the accretion column produces the modulated variation of the broad iron line. In addition, the non-pulsed narrow line is suggested to come from the outer disk region.

Published
2024

4. Pulse profile variability associated with the glitch of PSR J1048$-$5832

Author

Liu, P., Yuan, J. -P., Ge, M. -Y., Ye, W. -T., Zhou, S. -Q., Dang, S. -J., Zhou, Z. -R., Gügercinoğlu, E., Wang, W. -H., Wang, P., Li, A., Li, D., and Wang, N.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Nuclear Theory
Abstract

PSR J1048$-$5832 (B1046$-$58) is a Vela-like pulsar that has exhibited multiple glitch events. In this study, we analyze the timing data spanning nearly 16 years, acquired from both the Fermi Gamma-ray Space Telescope and the Parkes 64 m radio telescope. As a result, a total of five glitches are detected within this dataset. Among them, a previously unknown small glitch is newly found at MJD 56985(9) (November 24, 2014), making it the smallest glitch recorded from this source so far. The increments of the spin frequency and its first derivative are $\Delta \nu \approx 2.2(3) \times 10^ {-8} $ Hz, and $\Delta \dot{\nu} \approx 3(2) \times 10^ {-15}$ s$^{-2}$, respectively. Significant changes in the integrated normalized mean pulse profile are detected following three of the five glitch events, notably in the radio band. Although no evidence of a correlation is found between the spin-down rate and profile evolution, the jump phenomenon of $W_{55}$ (pulse width at the 55% peak amplitude) after the glitch in the narrow mode suggests that the glitch may influence the profile change. We discuss the influence of glitches on the pulsar's emission properties in terms of platelet motion by a crustquake and also put constraints on the equation of state from the moment of inertia and response timescales of involved superfluid layers inside the neutron star., Comment: 14 pages, 7 figures, 6 tables, MNRAS (2024) accepted

Published
2023

5. Timing properties of the X-ray accreting pulsar RX J0440.9+4431 studied with Insight-HXMT and NICER

Author

Li, P. P., Tao, L., Tuo, Y. L., Ge, M. Y., Kong, L. D., Zhang, L., Bu, Q. C., Ji, L., Qu, J. L., Zhang, S., Zhang, S. N., Huang, Y., Ma, X., Ye, W. T., Zhao, Q. C., Ma, R. C., Zhao, S. J., Hou, X., Yang, Z. X., Wang, P. J., Jia, S. M., Shui, Q. C., and Guan, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract

RX J0440.9+4431, a Be/X-ray binary, had its brightest outburst in 2022 since its discovery, with a peak X-ray flux of 2.25 Crab (as recorded by Swift/BAT, 15-50 keV). We analyze the timing properties of this giant outburst using data from Insight-HXMT and NICER, focusing on the evolution of the pulse profile and pulse fraction. We observe that when the luminosity reached around ~ 3*10^{37} er s^{-1}, a transition from double-peaked to single-peaked pulse profiles occurred across the energy range, with the peak of the low-energy profile aligning gradually with the peak of the high-energy profile. This change indicates a transition from subcritical to supercritical accretion. Additionally, we found a concave in the pulse fraction as a function of energy around 20-30 keV throughout the entire outburst period. Compared to the low luminosity, the concave becomes weaker in high luminosities, and overall, the pulse fraction is higher. We propose that this concave could be caused by the scattering of high-energy photons by the atmosphere of a neutron star, leading to a dilution of the pulse fraction. As the accretion reaches the supercritical state, the accretion column height increases, resulting in a larger direct component of strongly beamed X-ray flux, and an elevated pulse fraction., Comment: 15 pages, 8 figures, accepted for publication in MNRAS

Published
2023

8. Detection of a strong ~2.5 Hz modulation in the Newly Discovered Millisecond Pulsar MAXI J1816-195

Author

Li, P. P., Tao, L., Zhang, L., Bu, Q. C., Qu, J. L., Ji, L., Wang, P. J., Chen, Y. P., Zhang, S., Ma, R. C., Yang, Z. X., Ye, W. T., Zhao, S. J., Zhao, Q. C., Huang, Y., Ma, X., Qiao, E. L., Jia, S. M., and Zhang, S. N.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

MAXI J181-195 is a newly discovered accreting millisecond X-ray pulsar that went outburst in June 2022. Through timing analysis with NICER and NuSTAR observations, we find a transient modulation at ~2.5 Hz during the decay period of MAXI J1816-195. The modulation is strongly correlated with a spectral hardening, and its fractional rms amplitude increases with energy. These results suggest that the modulation is likely to be produced in an unstable corona. In addition, the presence of the modulation during thermonuclear bursts indicates that it may originate from a disk-corona where the optical depth is likely the main factor affecting the modulation, rather than temperature. Moreover, we find significant reflection features in the spectra observed simultaneously by NICER and NuSTAR, including a relativistically broadened Fe-K line around 6-7 keV, and a Compton hump in the 10-30 keV energy band. The radius of the inner disc is constrained to be Rin = (1.04-1.23) RISCO based on reflection modeling of the broadband spectra. Assuming that the inner disc is truncated at the magnetosphere radius, we estimate that the magnetic field strength is < 4.67 * 10e8 G., Comment: 12 pages, 13 figures

Published
2023
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9. Determination of ED90s of Phenylephrine and Norepinephrine Infusion for Prevention of Spinal Anesthesia-Induced Hypotension in Patients with Preeclampsia During Cesarean Delivery

Author

Tan H, Chen Y, Jiang Y, Sun X, Ye W, Zhu X, and Xiong X

Subjects
ed90, phenylephrine, norepinephrine, spinal anesthesia-induced hypotension, preeclampsia, cesarean delivery, Therapeutics. Pharmacology, RM1-950
Abstract

Haijie Tan,1,&ast; Yi Chen,2,&ast; Yan Jiang,1 Xiaojing Sun,1 Wei Ye,1 Xuefang Zhu,1 Xiangsheng Xiong1 1Department of Anesthesiology, The Fifth People’s Hospital of Huaian, Huaian, People’s Republic of China; 2Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiangsheng Xiong, Department of Anesthesiology, The Fifth People’s Hospital of Huaian, Huaian, People’s Republic of China, Email 158193942@qq.comBackground: Vasopressors remain an important strategy for managing spinal anesthesia-induced hypotension in women with preeclampsia. The aim of this study was to investigate the ED90s and efficacy ratio of phenylephrine and norepinephrine in managing spinal anesthesia-induced hypotension in women with preeclampsia during cesarean delivery.Methods: 60 women with preeclampsia, who underwent cesarean delivery, were randomly assigned to receive either a continuous intravenous infusion of phenylephrine or norepinephrine following spinal anesthesia. The initial dosage of phenylephrine or norepinephrine for the first women was 0.5 or 0.05 μg/kg/min, respectively, and subsequent infusion dosages were adjusted based on their efficacy in preventing spinal anesthesia-induced hypotension (defined as a systolic blood pressure less than 80% of the baseline level). The incremental or decremental doses of phenylephrine or norepinephrine were set at 0.1 or 0.01 μg/kg/min. The primary outcomes were the ED90s and efficacy ratio of phenylephrine and norepinephrine infusions for preventing spinal anesthesia-induced hypotension prior to delivery.Results: The results obtained from isotonic regression analysis revealed that the ED90 values of the phenylephrine and norepinephrine group for preventing spinal anesthesia-induced hypotension were 0.597 (95% CI: 0.582– 0.628) and 0.054 (95% CI: 0.053– 0.056) μg/kg/min, respectively, with an efficacy ratio of 11.1:1. The results of Probit regression analysis revealed that the ED90 values were determined to be 0.665 (95% CI: 0.576– 1.226) and 0.055 (95% CI: 0.047– 0.109) μg/kg/min, respectively, with an efficacy ratio of 12.1:1.Conclusion: The administration of 0.6 μg/kg/min phenylephrine and 0.05 μg/kg/min norepinephrine has been found to effectively manage a 90% incidence of spinal anesthesia-induced hypotension in women with preeclampsia.Keywords: ED90, phenylephrine, norepinephrine, spinal anesthesia-induced hypotension, preeclampsia, cesarean delivery

Published
2024

10. Association Between Urinary Phthalate Metabolites and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

Author

Li X, Li Z, Ye J, and Ye W

Subjects
chronic obstructive pulmonary disease, phthalate, airflow obstruction, lung function, national health and nutrition examination survey, Diseases of the respiratory system, RC705-779
Abstract

Xuefang Li,1 Zhijun Li,2 Jian Ye,2 Wu Ye2 1Department of Infectious Diseases, Zhejiang Hospital, Hangzhou, People’s Republic of China; 2Department of Respiratory Diseases, Zhejiang Hospital, Hangzhou, People’s Republic of ChinaCorrespondence: Wu Ye, Department of Respiratory Diseases, Zhejiang Hospital, 1229 Gudun Road, Xihu District, Hangzhou, Zhejiang Province, 310013, People’s Republic of China, Tel +86 15158100052, Email yewu55@126.comObjective: To determine the association of urinary phthalate metabolites with chronic obstructive pulmonary disease (COPD), airflow obstruction, lung function and respiratory symptoms.Methods: Our study included a total of 2023 individuals aged ≥ 40 years old in the National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression was conducted to explore the correlation of eleven urinary phthalate metabolites (MCNP, MCOP, MECPP, MnBP, MCPP, MEP, MEHHP, MEHP, MiBP, MEOHP, and MBzP) with COPD, airflow obstruction and respiratory symptoms. Linear regression analyses were used to evaluate the relationship between urinary phthalate metabolites and lung function.Results: When compared to the first tertile, the third tertile of MEHHP was associated with the risk of COPD [OR: 2.779; 95% confidence interval (CI): 1.129– 6.840; P = 0.026]. Stratified analysis showed that MEHHP increased the risk of COPD by 7.080 times in male participants. Both MCPP and MBzP were positively correlated with the risk of airflow obstruction. The third tertile of MBzP increased the risk of cough by 1.545 (95% CI: 1.030– 2.317; P = 0.035) times. Both FEV1 and FVC were negatively associated with MEHHP, MECPP, MnBP, MEP, MiBP and MEOHP.Conclusion: Higher levels of MEHHP are associated with increased risk of COPD, and lower measures of FEV1 and FVC. MBzP is positively related to airflow obstruction and cough.Keywords: chronic obstructive pulmonary disease, phthalate, airflow obstruction, lung function, national health and nutrition examination survey

Published
2024

11. Comparison of Clinical Manifestations and Related Factors of Hepatocellular Carcinoma with Chronic Hepatitis B

Author

Hou H, Liang L, Deng L, Ye W, Wen Y, and Liu J

Subjects
chronic hepatitis b, hepatocellular carcinoma, cirrhosis, hepatitis b virus, Medicine (General), R5-920
Abstract

Haisong Hou,1,2 Liu Liang,3 Lihong Deng,4 Wanping Ye,5 Yuanzhang Wen,6 Jun Liu1 1Laboratory of Pathogenic Biology, Guangdong Medical University, Zhanjiang, People’s Republic of China; 2Department of Blood Transfusion, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 3Department of Laboratory Medicine, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 4Department of Hepatology, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 5Department of Gastroenterology, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 6Department of Hepatobiliary Surgery, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of ChinaCorrespondence: Jun Liu, Laboratory of Pathogenic Biology, Guangdong Medical University, Zhanjiang, People’s Republic of China, Email liujungd6@163.comBackground: The aim of this study was to describe the demographic and clinical characteristics of hepatitis B virus (HBV) associated hepatocellular carcinoma (HCC), analyse the risk factors associated with HBV-associated HCC, and to provide some references to the diagnosis and treatment of HCC.Methods: This study retrospectively enrolled 730 patients, including 390 patients with chronic hepatitis B (CHB) as controls, and 340 patients with CHB complicated with HCC as patients. Relevant information and medical records of these participants were collected, including age, sex, cigarette smoking, alcoholism, diabetes mellitus (DM), hypertension, coronary heart disease (CHD), cirrhosis, occupation, ascites, HBV-DNA load, the qualitative analysis of HBsAg, HBsAb, HBeAg, HBeAb, and HBcAb serological markers, and levels of alanine transaminase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), gamma-glutamyltransferase (GGT), TNM stage, tumor size and tumor number. The T test, Chi-square test, non-parametric rank-sum test, logistic regression analyses were used to explore the influencing factors and their degree of association with HCC in patients with HBV.Results: The proportion of smoking, alcoholism, married status, DM, hypertension, and the rate of HBV-DNA with a viral load of ≥ 500 copies/mL were significantly higher in the HCC group than in the controls (all p< 0.05). Cirrhosis was more common among patients with CHB+HCC than in controls (p=0.013). The proportion of patients with HBsAg, HBeAb, and HBcAb positive was greater in CHB+HCC group than that in CHB group. Logistic regression analysis indicated that age ≥ 60 years (OR: 1.835, 95% CI: 1.020– 3.302, p=0.043), HBeAb positive (OR: 9.105, 95% CI: 4.796– 17.288, p< 0.001), antiviral treatment with entecavir (OR: 2.209, 95% CI: 1.106– 4.409, p=0.025), and GGT (OR: 1.004, 95% CI: 1.001– 1.007, p=0.002) were risk factors for HCC in patients with CHB.Conclusion: Advanced age, HBeAb positive, antiviral treatment with entecavir, and GGT were independent risk factors for HCC in HBV patients.Keywords: chronic hepatitis B, hepatocellular carcinoma, cirrhosis, hepatitis B virus

Published
2024

12. Psychological Responses of Chinese Medical Students to the COVID-19 Pandemic: Empirical Research Qualitative

Author

Fan S, Zhao Y, Wang S, Zhang N, Li Z, Liu H, Wei Y, Yu Y, Gu Y, Wei Q, Ye W, Feng N, and Liu F

Subjects
covid-19, medical students, psychological reactions, pandemic, mental health, Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract

Siyu Fan,1,&ast; Yu Zhao,1,&ast; Shiyu Wang,1,&ast; Na Zhang,1,&ast; Zhi Li,1,&ast; Hongyuan Liu,1 Yaodi Wei,1 Yunhui Yu,1 Yifeng Gu,2 Qun Wei,3 Weijuan Ye,4 Ninghan Feng,5 Fengping Liu1 1Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, People’s Republic of China; 2Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China; 3Department of Surgical Oncology, Institute of Clinical Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 4Lishui Maternal and Child Health center, Lishui, Zhejiang, People’s Republic of China; 5Department of Urology, Jiangnan University Medical Center, Wuxi, Jiangsu, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ninghan Feng, Department of Urology, Jiangnan University Medical Center, Wuxi, Jiangsu, 214002, People’s Republic of China, Email n.feng@njmu.edu.cn Fengping Liu, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, People’s Republic of China, Email liulaoshiyc@jiangnan.edu.cnAim: This study aims to explore the psychological reactions of medical students during the pandemic.Design: A qualitative study.Methods: A purposive sampling technique was employed, and a qualitative approach was adopted. Semi-structured questionnaires were utilized, and online interviews were conducted. Forty medical students were selected as participants for the interviews. The interview data were analyzed using Colaizzi’s seven-step analysis method.Results: The study identified five themes related to the psychological reactions of medical students during the pandemic. Firstly, COVID-19’s influence on medical careers was characterized by increased interest and determination in pursuing medical professions, heightened admiration for frontline workers, reinforced commitment to a medical career due to the pandemic, and recognition of the significance of medical education. Secondly, challenges and concerns in medical career pursuit were identified, including negative sentiments towards medical careers during COVID-19 and hesitations and concerns about entering the medical field amidst the pandemic. Thirdly, the impact on mental well-being encompassed diverse anxieties expressed by participants regarding control, transmission, treatment, and intentional spreading of the virus. Participants experienced an emotional progression from calmness to fear and anxiety, with heightened anxiety when relatives or acquaintances contracted COVID-19. Academic delays also contributed to anxiety among medical students. Fourthly, changes in behaviors and mindset were observed, including altered behaviors and mindset in response to the pandemic, as well as increased attention to personal hygiene and disease prevention measures. Lastly, expectations of medical students from government, public, and parents were explored.Conclusion: Understanding the psychological reactions of medical students during public health emergencies is crucial for their well-being and professional development. The findings have implications for medical education and the development of strategies to enhance the psychological well-being of medical students during similar crises.Keywords: COVID-19, medical students, psychological reactions, pandemic, mental health

Published
2024

14. Aldehyde dehydrogenase 2 rs671 a/A Genotype is Associated with an Increased Risk of Early Onset Coronary Artery Stenosis

Author

Rao H, Wang X, Luo Y, Liang L, Ye W, and Guo X

Subjects
aldehyde dehydrogenase 2, gene polymorphism, coronary artery stenosis, early onset, Medicine (General), R5-920
Abstract

Hui Rao,1 Xianfang Wang,2 Yu Luo,3 Liu Liang,1 Wei Ye,1 Xuemin Guo1 1Department of Laboratory Medicine, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Center for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 3Department of Gynaecology, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of ChinaCorrespondence: Xuemin Guo, Department of Laboratory Medicine, Meizhou People’s Hospital, No. 63 Huangtang Road, Meijiang District, Meizhou, People’s Republic of China, Email Guoxm12@126.comBackground: The role of aldehyde dehydrogenase 2 (ALDH2) in cardiovascular diseases has been gradually studied. However, it is unclear whether ALDH2 polymorphism is associated with the risk of early onset (onset age ≤ 55 years old in men and ≤ 65 years old in women) coronary artery stenosis (CAS). The association between ALDH2 single nucleotide polymorphism (SNP) rs671 and risk in patients with early onset CAS was investigated in this study.Methods: The study included 213 early onset CAS patients and 352 individuals without CAS were set as controls. The ALDH2 rs671 polymorphism was genotyped by polymerase chain reaction (PCR) - microarray. Differences in ALDH2 rs671 genotypes and alleles between patients and controls were compared. Multiple logistic regression analysis was performed after adjusting for gender, body mass index (BMI), smoking history, drinking history, and diabetes mellitus to assess the relationship between ALDH2 rs671 genotypes and early onset CAS risk.Results: The frequency of the ALDH2 rs671 G/G genotype was lower in the early onset CAS patients (43.7% vs 55.3%, p=0.007) than that in the controls. The frequency of the ALDH2 rs671 A allele was higher (32.9% vs 25.0%) than that in the controls (p=0.005). After adjusting for other confounding factors, multivariate logistic regression showed that ALDH2 rs671 A/A genotype (A/A vs G/G: odds ratio (OR) 2.508, 95% confidence interval (CI): 1.130– 5.569, p=0.024), overweight (BMI≥ 24.0 vs 18.5– 23.9: OR 5.047, 95% CI: 3.275– 7.777, p< 0.001), history of smoking (yes vs no: OR 2.813, 95% CI: 1.595– 4.961, p< 0.001), and diabetes mellitus (yes vs no: OR 2.191, 95% CI: 1.397– 3.437, p=0.001) were the independent risk factors of early onset CAS.Conclusion: In men ≤ 55 years old and women ≤ 65 years old, individuals with ALDH2 rs671 A/A genotype, overweight (BMI ≥ 24.0 kg/m2), smoking history, and diabetes mellitus increased risk of developing CAS.Keywords: aldehyde dehydrogenase 2, gene polymorphism, coronary artery stenosis, early onset

Published
2024

15. Long Non-Coding RNA B3GALT5-AS1 Suppresses Keloid Progression by Regulating the β-Trcp1-Mediated Ubiquitination of HuR

Author

Ye W, Lu J, Yang Z, Yang B, Zhu G, and Xue C

Subjects
b3galt5-as1, keloid, fibroblast, hur, β-trcp1, Dermatology, RL1-803
Abstract

Wei Ye,1,&ast; Junwen Lu,1,&ast; Zuxian Yang,2 Ben Yang,2 Guanya Zhu,2 Chunli Xue2 1Department of Burn Surgery, the First Clinical Medical College of Guangdong Medical University, Huizhou, 516001, People’s Republic of China; 2Department of Burn Surgery, Huizhou Municipal Central Hospital, Huizhou, 516001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chunli Xue, Department of Burn Surgery, Huizhou Municipal Central Hospital, No. 41, Eiling North Road, Huicheng District, Huizhou, 516001, People’s Republic of China, Email xuechunli2001@163.comBackground: lncRNA β‑1,3‑galactosyltransferase 5‑AS1 (B3GALT5-AS1) plays a vital regulatory role in colon and gastric cancers. However, the biological functions and regulatory mechanisms of B3GALT5-AS1 in keloid progression remain unknown. This study aims to investigate the molecular mechanisms in the B3GALT5-AS1-regulated keloid proliferation and invasion.Methods: Secondary mining of the lncRNA sequencing data from GSE158395 was conducted to screen differentially expressed lncRNAs between keloid and normal tissues. MTT, cell migration and invasion assays were performed to detect the effects of B3GALT5-AS1 on keloid fibroblasts (KFs) proliferation and metastasis. The extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) were also determined to evaluate glycolysis in KFs. RNA pull-down and RNA-protein immunoprecipitation assays were used to confirm the interaction between B3GALT5-AS1 and Hu-Antigen R (HuR). Further ubiquitination and rescue experiments were performed to elucidate the regulatory relationship between B3GALT5-AS1 and HuR.Results: B3GALT5-AS1 was significantly down-regulated in keloid tissues and fibroblasts. B3GALT5-AS1 overexpression significantly inhibited KFs proliferation, glycolysis, invasion, and migration and promoted cell apoptosis, whereas silencing B3GALT5-AS1 inhibited these effects. Moreover, B3GALT5-AS1 binds to HuRand reduces its stability through β-Transducin repeats-containing protein 1 (β-Trcp1)-mediated ubiquitination. Overexpression of HuR reversed the inhibition of B3GALT5-AS1 on cell proliferation, migration, and invasion in KFs, where glycolysis pathway was involved.Conclusion: Our findings illustrate that B3GALT5-AS1 has great effect on inhibition of keloid formation, which provides a potential target for keloid therapy.Keywords: B3GALT5-AS1, keloid, fibroblast, HuR, β-Trcp1

Published
2024

16. Quantum-improved phase estimation with a displacement-assisted SU(1,1) interferometer

Author

Ye, W., Chang, S. K., Gao, S. Y., Zhang, H., Xia, Y., and Rao, X.

Subjects
Quantum Physics
Abstract

By performing two local displacement operations (LDOs) inside an SU(1,1) interferometer, called as the displacement-assisted SU(1,1) [DSU(1,1)], both the phase sensitivity based on homodyne detection and quantum Fisher information (QFI) with and without photon losses are investigated in this paper. In this DSU(1,1) interferometer, we focus our attention on the extent to which the introduced LDO affects the phase sensitivity and the QFI, even in the realistic scenario. Our analyses show that the estimation performance of DSU(1,1) interferometer is always better than that of SU(1,1) interferometer without the LDO, especially the phase precision of the former in the ideal scenario gradually approaching to the Heisenberg limit via the increase of the LDO strength. More significantly, different from the latter, the robustness of the former can be enhanced markedly by regulating and controlling the LDO. Our findings would open an useful view for quantum-improved phase estimation of optical interferometers., Comment: 12 pages, 11 figures

Published
2022

17. Fibroblast Insights into the Pathogenesis of Ankylosing Spondylitis

Author

Liu Z, Cai M, Ke H, Deng H, Ye W, Wang T, Chen Q, and Cen S

Subjects
ankylosing spondylitis, fibroblast, inflammation, ossification, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Zhenhua Liu,1,&ast; Mingxi Cai,2,&ast; Haoteng Ke,2,&ast; Huazong Deng,2 Weijia Ye,2 Tao Wang,1 Qifan Chen,1 Shuizhong Cen1 1Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, People’s Republic of China; 2The Second Clinical School, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Shuizhong Cen, Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Tel +86 13480297160, Email censhzh3@mail2.sysu.edu.cnPurpose of the Review: Emerging evidence has shown that ankylosing spondylitis fibroblasts (ASFs) act as crucial participants in inflammation and abnormal ossification in ankylosing spondylitis (AS). This review examines the investigations into ASFs and their pathological behavior, which contributes to inflammatory microenvironments and abnormal bone formation. The review spans the period from 2000 to 2023, with a primary focus on the most recent decade. Additionally, the review provides an in-depth discussion on studies on ASF ossification at the cellular level.Recent Findings: ASFs organize immune functions by recruiting immune cells and influencing their differentiation and activation, thus mediate the inflammatory response in the early phase of disease. ASFs promote joint destruction at sites of cartilage and actively promote abnormal ossification by recruiting osteoblasts, differentiation into myofibroblasts or ossification directly. Many signaling pathways and cytokines such as Wnt signaling and BMP/TGF-β signaling are involved in ASF ossification.Summary: ASFs play a key role in AS inflammation and osteogenesis. Further studies are required to elucidate molecular mechanisms behind that and provide new targets and directions for AS diagnosis and treatment from a new perspective of fibroblasts.Keywords: ankylosing spondylitis, fibroblast, inflammation, ossification

Published
2023

18. Aerobic Exercise Ameliorates Liver Injury in Db/Db Mice by Attenuating Oxidative Stress, Apoptosis and Inflammation Through the Nrf2 and JAK2/STAT3 Signalling Pathways

Author

Sun M, Zhao X, Li X, Wang C, Lin L, Wang K, Sun Y, Ye W, Li H, Zhang Y, and Huang C

Subjects
db/db mice, aerobic exercise, inflammation, apoptosis, nrf2, jak2/stat3., Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Meiyan Sun,1,2,&ast; Xiaoyong Zhao,2,&ast; Xingyue Li,2 Chunling Wang,2 Lili Lin,3 Kaifang Wang,2 Yingui Sun,2 Wei Ye,3 Haiyan Li,3 Ye Zhang,1 Chaolu Huang2,4 1Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, People’s Republic of China; 2Department of Anesthesiology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, 261053, People’s Republic of China; 3The First Clinical Medical College, Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 4Department of Clinical Medicine, Qiandongnan Ethnic Vocational and Technical College, Kaili, 556000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ye Zhang, Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, People’s Republic of China, Email zhangy@ahmu.edu.cn Chaolu Huang, Department of Clinical Medicine, Qiandongnan Ethnic Vocational and Technical College, Kaili, 556000, People’s Republic of China, Email huangzhaolu2020@163.comObjective: Diabetes mellitus (DM) implicates oxidative stress, apoptosis, and inflammation, all of which may contribute liver injury. Aerobic exercise is assured to positively regulate metabolism in the liver. This project was designed to investigate whether and how aerobic exercise improves DM-induced liver injury.Methods: Seven-week-old male db/db mice and age-matched m/m mice were randomly divided into a rest control group or a group that received 12 weeks of aerobic exercise by treadmill training (10 m/min). Haematoxylin and eosin (HE) staining, electron microscopy, Oil Red O staining and TUNEL assays were used to evaluate the histopathological changes in mouse liver. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TRIG), cholesterol (CHOL) were analyzed by serum biochemical analysis. Interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), and tissue levels of malondialdehyde (MDA) and superoxide dismutase (SOD) were analyzed via ELISA. Nuclear factor E2-associated factor-2 (Nrf2), nuclear factor κB (NF-κB) and JAK2/STAT3 pathway-related proteins were measured by immunofluorescence, Western blotting and q-PCR. F4/80 expression in liver tissues was assessed by immunohistochemistry.Results: In diabetic mice, exercise training significantly decreased the levels of serum TRIG, CHOL, IL-6, TNF-α, ALT and AST; prevented weight gain, hyperglycaemia, and impaired glucose and insulin tolerance. Morphologically, exercise mitigated the diabetes-induced increase in liver tissue microvesicles, inflammatory cells, F4/80 (macrophage marker) levels, and TUNEL-positive cells. In addition, exercise reduced the apoptosis index, which is consistent with the results for caspase-3 and Bax. Additionally, exercise significantly increased SOD activity, decreased MDA levels, activated Nrf2 and decreased the expression of NF-kB, phosphorylated JAK2 and STAT3 proteins in the livers of diabetic mice.Conclusion: This study demonstrated that aerobic exercise reversed liver dysfunction in db/db mice with T2DM by reducing oxidative stress, apoptosis and inflammation, possibly by enhancing Nrf2 expression and inhibiting the JAK2/STAT3 cascade response.Keywords: db/db mice, aerobic exercise, inflammation, apoptosis, Nrf2, JAK2/STAT3

Published
2023

19. Metagenomics as New Tool for Diagnosis of Scrub Typhus: Two Case Reports

Author

Ling Y, Hu X, Zheng G, Ye W, Yuan K, Ye L, Huang W, Tian B, and Gu B

Subjects
scrub typhus, metagenomic next-generation sequencing, orientia tsutsugamushi, Medicine (General), R5-920
Abstract

Yong Ling,1,&ast; Xuejiao Hu,1,&ast; Guansheng Zheng,1 Weitao Ye,2 Kaixuan Yuan,1 Long Ye,1 Weiye Huang,3 Benshun Tian,1 Bing Gu1 1Department of Clinical Laboratory Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 510000, People’s Republic of China; 2Department of Radiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 510000, People’s Republic of China; 3Department of Pathology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 510000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Benshun Tian; Bing Gu, Department of Laboratory Medicine, Guangdong Provincial People’s Hospital, 106 Zhongshan 2nd Road, Yuexiu District, Guangzhou, Guangdong, 510000, People’s Republic of China, Email tbs20161017@163.com; gb20031129@163.comAbstract: Scrub typhus is a vector-borne infectious disease caused by Orientia tsutsugamushi. Accurate and timely diagnosis at the early infection stage could save the patients’ lives. Traditional technologies were limited to rapidly and successfully detecting Orientia tsutsugamushi due to poor specificity, especially in the condition of atypical symptoms. The technology of Metagenomic next-generation sequencing (mNGS) is amenable to finding the real pathogen because it holds potential as a diagnostic platform for unbiased pathogen identification and precision medicine. Herein, we reported two clinical case reports relative to the Orientia tsutsugamushi infection diagnosed by mNGS. We hope these two cases will improve clinical diagnosis.Keywords: scrub typhus, metagenomic next-generation sequencing, Orientia tsutsugamushi

Published
2023

20. Cardiovascular Outcomes in GRADE (Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness Study)

Author

Green, Jennifer B., Everett, Brendan M., Ghosh, Alokananda, Younes, Naji, Krause-Steinrauf, Heidi, Barzilay, Joshua, Desouza, Cyrus, Inzucchi, Silvio E., Pokharel, Yashashwi, Schade, David, Scrymgeour, Alexandra, Tan, Meng H., Utzschneider, Kristina M., Mudaliar, Sunder, Crandall, J.P., McKee, M.D., Behringer-Massera, S., Brown-Friday, J., Xhori, E., Ballentine-Cargill, K., Duran, S., Estrella, H., Gonzalez de la Torre, S., Lukin, J., Phillips, L.S., Burgess, E., Olson, D., Rhee, M., Wilson, P., Raines, T.S., Boers, J., Costello, J., Maher-Albertelli, M., Mungara, R., Savoye, L., White, C.A., Gullett, C., Holloway, L., Morehead, F., Person, S., Sibymon, M., Tanukonda, S., Adams, C., Ross, A., Balasubramanyam, A., Gaba, R., Gonzalez Hattery, E., Ideozu, A., Jimenez, J., Montes, G., Wright, C., Hollander, P., Roe, E., Jackson, A., Smiley, A., Burt, P., Estrada, L., Chionh, K., Ismail-Beigi, F., Falck-Ytter, C., Sayyed Kassem, L., Sood, A., Tiktin, M., Kulow, T., Newman, C., Stancil, K.A., Cramer, B., Iacoboni, J., Kononets, M.V., Sanders, C., Tucker, L., Werner, A., Maxwell, A., McPhee, G., Patel, C., Colosimo, L., Krol, A., Goland, R., Pring, J., Alfano, L., Kringas, P., Hausheer, C., Tejada, J., Gumpel, K., Kirpitch, A., Schneier, H., AbouAssi, H., Chatterjee, R., Feinglos, M.N., English Jones, J., Khan, S.A., Kimpel, J.B., Zimmer, R.P., Furst, M., Satterwhite, B.M., Thacker, C.R., Evans Kreider, K., Mariash, C.N., Mather, K.J., Ismail, H.M., Lteif, A., Mullen, M., Hamilton, T., Patel, N., Riera, G., Jackson, M., Pirics, V., Aguillar, D., Howard, D., Hurt, S., Bergenstal, R., Carlson, A., Martens, T., Johnson, M., Hill, R., Hyatt, J., Jensen, C., Madden, M., Martin, D., Willis, H., Konerza, W., Yang, S., Kleeberger, K., Passi, R., Fortmann, S., Herson, M., Mularski, K., Glauber, H., Prihoda, J., Ash, B., Carlson, C., Ramey, P.A., Schield, E., Torgrimson-Ojerio, B., Arnold, K., Kauffman, B., Panos, E., Sahnow, S., Bays, K., Berame, K., Cook, J., Ghioni, D., Gluth, J., Schell, K., Criscola, J., Friason, C., Jones, S., Nazarov, S., Rassouli, N., Puttnam, R., Ojoawo, B., Nelson, R., Curtis, M., Hollis, B., Sanders-Jones, C., Stokes, K., El-Haqq, Z., Kolli, A., Tran, T., Wexler, D., Larkin, M.E., Meigs, J., Chambers, B., Dushkin, A., Rocchio, G., Yepes, M., Steiner, B., Dulin, H., Cayford, M., Chu, K., DeManbey, A., Hillard, M., Martin, K., Thangthaeng, N., Gurry, L., Kochis, R., Raymond, E., Ripley, V., Stevens, C., Park, J., Aroda, V., Ghazi, A., Magee, M., Ressing, A., Loveland, A., Hamm, M., Hurtado, M., Kuhn, A., Leger, J., Manandhar, L., Mwicigi, F., Sanchez, O., Young, T., Garg, R., Lagari-Libhaber, V., Florez, H.J., Valencia, W.M., Marks, J., Casula, S., Oropesa-Gonzalez, L., Hue, L., Cuadot, A., Nieto-Martinez, R., Riccio Veliz, A.K., Gutt, M., Kendal, Y.J., Veciana, B., Ahmann, A., Aby-Daniel, D., Joarder, F., Morimoto, V., Sprague, C., Yamashita, D., Cady, N., Rivera-Eschright, N., Kirchhoff, P., Morales Gomez, B., Adducci, J., Goncharova, A., Hox, S.H., Petrovitch, H., Matwichyna, M., Jenkins, V., Broadwater, L., Ishii, R.R., Bermudez, N.O., Hsia, D.S., Cefalu, W.T., Greenway, F.L., Waguespack, C., King, E., Fry, G., Dragg, A., Gildersleeve, B., Arceneaux, J., Haynes, N., Thomassie, A., Pavlionis, M., Bourgeois, B., Hazlett, C., Henry, R., Boeder, S., Pettus, J., Diaz, E., Garcia-Acosta, D., Maggs, S., DeLue, C., Stallings, A., Castro, E., Hernandez, S., Krakoff, J., Curtis, J.M., Killean, T., Khalid, M., Joshevama, E., Diaz, E., Martin, D., Tsingine, K., Karshner, T., Albu, J., Pi-Sunyer, F.X., Frances, S., Maggio, C., Ellis, E., Bastawrose, J., Gong, X., Banerji, M.A., August, P., Lee, M., Lorber, D., Brown, N.M., Josephson, D.H., Thomas, L.L., Tsovian, M., Cherian, A., Jacobson, M.H., Mishko, M.M., Kirkman, M.S., Buse, J.B., Diner, J., Dostou, J., Machineni, S., Young, L., Bergamo, K., Goley, A., Kerr, J., Largay, J.F., Guarda, S., Cuffee, J., Culmer, D., Fraser, R., Almeida, H., Coffer, S., Debnam, E., Kiker, L., Morton, S., Josey, K., Fuller, G., Garvey, W.T., Cherrington, A.L., Dyer, D., Lawson, M.C.R., Griffith, O., Agne, A., McCullars, S., Cohen, R.M., Craig, J., Rogge, M.C., Burton, K., Kersey, K., Wilson, C., Lipp, S., Vonder Meulen, M.B., Adkins, C., Onadeko, T., Rasouli, N., Baker, C., Schroeder, E., Razzaghi, M., Lyon, C., Penaloza, R., Underkofler, C., Lorch, R., Douglass, S., Steiner, S., Sivitz, W.I., Cline, E., Knosp, L.K., McConnell, J., Lowe, T., Herman, W.H., Pop-Busui, R., Martin, C., Waltje, A., Katona, A., Goodhall, L., Eggleston, R., Kuo, S., Bojescu, S., Bule, S., Kessler, N., LaSalle, E., Whitley, K., Seaquist, E.R., Bantle, A., Harindhanavudhi, T., Kumar, A., Redmon, B., Bantle, J., Coe, M., Mech, M., Taddese, A., Lesne, L., Smith, S., Kuechenmeister, L., Shivaswamy, V., Burbach, S., Rodriguez, M.G., Seipel, K., Alfred, A., Morales, A.L., Eggert, J., Lord, G., Taylor, W., Tillson, R., Adolphe, A., Burge, M., Duran-Valdez, E., Martinez, J., Bancroft, A., Kunkel, S., Ali Jamaleddin Ahmad, F., Hernandez McGinnis, D., Pucchetti, B., Scripsick, E., Zamorano, A., DeFronzo, R.A., Cersosimo, E., Abdul-Ghani, M., Triplitt, C., Juarez, D., Mullen, M., Garza, R.I., Verastiqui, H., Wright, K., Puckett, C., Raskin, P., Rhee, C., Abraham, S., Jordan, L.F., Sao, S., Morton, L., Smith, O., Osornio Walker, L., Schnurr-Breen, L., Ayala, R., Kreymer, R.B., Sturgess, D., Kahn, S.E., Alarcon-Casas Wright, L., Boyko, E.J., Tsai, E.C., Trence, D.L., Trikudanathan, S., Fattaleh, B.N., Montgomery, B.K., Atkinson, K.M., Kozedub, A., Concepcion, T., Moak, C., Prikhodko, N., Rhothisen, S., Elasy, T.A., Martin, S., Shackelford, L., Goidel, R., Hinkle, N., Lovell, C., Myers, J., Lipps Hogan, J., McGill, J.B., Salam, M., Schweiger, T., Kissel, S., Recklein, C., Clifton, M.J., Tamborlane, W., Camp, A., Gulanski, B., Pham, K., Alguard, M., Gatcomb, P., Lessard, K., Perez, M., Iannone, L., Magenheimer, E., Montosa, A., Cefalu, W.T., Fradkin, J., Burch, H.B., Bremer, A.A., Nathan, D.M., Lachin, J.M., Buse, J.B., Kahn, S.E., Larkin, M.E., Tiktin, M., Wexler, D., Burch, H.B., Bremer, A.A., Lachin, J.M., Bebu, I., Butera, N., Buys, C.J., Fagan, A., Gao, Y., Gramzinski, M.R., Hall, S.D., Kazemi, E., Legowski, E., Liu, H., Suratt, C., Tripputi, M., Arey, A., Backman, M., Bethepu, J., Lund, C., Mangat Dhaliwal, P., McGee, P., Mesimer, E., Ngo, L., Steffes, M., Seegmiller, J., Saenger, A., Arends, V., Gabrielson, D., Conner, T., Warren, S., Day, J., Huminik, J., Soliman, E.Z., Zhang, Z.M., Campbell, C., Hu, J., Keasler, L., Hensley, S., Li, Y., Herman, W.H., Kuo, S., Martin, C., Waltje, A., Mihalcea, R., Min, D.J., Perez-Rosas, V., Prosser, L., Resnicow, K., Ye, W., Shao, H., Zhang, P., Luchsinger, J., Sanchez, D., Assuras, S., Groessl, E., Sakha, F., Chong, H., Hillery, N., Abdouch, I., Bahtiyar, G., Brantley, P., Broyles, F.E., Canaris, G., Copeland, P., Craine, J.J., Fein, W.L., Gliwa, A., Hope, L., Lee, M.S., Meiners, R., Meiners, V., O’Neal, H., Park, J.E., Sacerdote, A., Sledge Jr, E., Soni, L., Steppel-Reznik, J., and Turchin, A.

Published
2024
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21. Transformation of Lung Squamous Cell Carcinoma to Small Cell Lung Cancer After Immunotherapy Resistance: A Case Report

Author

Wang D, Ye W, Chen D, Shi Q, and Ma D

Subjects
lung squamous cell carcinoma, immunotherapy, small cell transformation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Diming Wang,1,&ast; Wei Ye,2,&ast; Dongmei Chen,1 Qingming Shi,1 Dongchun Ma3 1Department of Oncology, Anhui Chest Hospital, Hefei, 230022, People’s Republic of China; 2Department of Pathology, Anhui Chest Hospital, Hefei, 230022, People’s Republic of China; 3Department of Thoracic Surgery, Anhui Chest Hospital, Hefei, 230022, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Dongchun Ma, Department of Thoracic Surgery, Anhui Chest Hospital, Hefei, 230022, People’s Republic of China, Email madongchun126@126.com Qingming Shi, Department of Oncology, Anhui Chest Hospital, Hefei, 230022, People’s Republic of China, Email shqm0324@163.comAbstract: The transformation of lung adenocarcinoma to small cell lung cancer (SCLC) following treatment with epidermal growth factor (EGFR) receptor tyrosine kinase inhibitors (TKIs) is a relatively common phenomenon. However, transformation of non-small cell lung cancer (NSCLC) to SCLC following treatment with immunotherapy is very rare. Here, we report a case of a 56-year-old patient diagnosed with driver gene mutation-negative lung squamous cell carcinoma (SCC). He received four cycles of immunotherapy with sugemalimab and chemotherapy with albumin paclitaxel in combination with carboplatin, and a partial response was achieved. Subsequently, the patient received 5 cycles of immunotherapy with sugemalimab. However, he developed rapid progression of mediastinal lymph nodes, and biopsy results showed transformation to SCLC. His tumor did not respond to the next line of carboplatin combined with etoposide, and he died six months after the discovery of SCLC transformation. In conclusion, SCLC transformation is also an important resistance mechanism for lung SCC patients treated with immunotherapy and predicts a very poor outcome. Repeat biopsy is needed for advanced lung SCC that has progressed with immunotherapy.Keywords: lung squamous cell carcinoma, immunotherapy, small cell transformation

Published
2023

22. Assessing the Knowledge, Attitudes, and Vaccination Practices Towards COVID-19 Vaccination Among Mainland Chinese Nursing Students and Interns: A Multicenter Cross-Sectional Study

Author

Qin Z, Ye X, Liu H, Tao Y, Zheng X, Zhong Y, Chen D, Ye W, and Zhan C

Subjects
covid-19, vaccine, knowledge, attitudes, practice, nursing students and interns., Infectious and parasitic diseases, RC109-216
Abstract

Zhuzhu Qin,1,&ast; Xinxin Ye,2,&ast; Huanju Liu,3 Yining Tao,4 Xutong Zheng,1 Yanxia Zhong,5 Danfeng Chen,1 Wan Ye,6 Chenju Zhan7 1School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China; 2Department of Sports and Exercise Science, College of Education, Zhejiang University, Hangzhou, Zhejiang, China; 3Women’s Hospital and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, China; 4Department of Global Public Health, Karolinska Institute, Stockholm, Sweden; 5Department of Nursing, Shijiazhuang Medical College, Shijiazhuang, China; 6Department of Nursing, Xiamen Medical College, Xiamen, Fujian, China; 7Department of Nursing, Mindong Hospital Affiliated to Fujian Medical University, Ningde, China&ast;These authors contributed equally to this workCorrespondence: Wan Ye, Department of Nursing, Xiamen Medical College, Xiamen, Fujian, China, Tel +86 13806086169, Email 200600010142@xmmc.edu.cn Chenju Zhan, Department of Nursing, Mindong Hospital Affiliated to Fujian Medical University, No. 89 HeShan Road, Fuan City, Fujian Province, 355000, China, Tel +86 13809562183, Email zhanchenju@yeah.netObjective: This study investigated factors influencing the knowledge, attitudes, practice profiles, and vaccination intentions among Chinese nursing students and nursing interns toward the coronavirus disease (COVID-19) vaccination.Materials and Methods: The multicenter cross-sectional study was based on a self-reported questionnaire collecting information among nursing students and nursing interns from three major geographic regions of China, and the sample was selected by consecutive sampling. The questionnaire was developed by knowledge, attitudes, and practice (KAP) theory. Univariate and multivariate logistic regression were used for statistical analysis.Results: A total of 3180 nursing students and interns (effective rate: 99.8%) from six Chinese provinces were polled. The vaccine hesitation rate was 9.65% (307/3180), 2230 participants (70.1%) had gotten at least one dose of the vaccine, and 643 participants (67.7%) had indicated a readiness to be vaccinated. The results showed that older age, higher academic background, perfect vaccine management, others’ recommendations, influenza vaccination history, epidemic under control, knowledge of vaccines or intervals, and vaccine knowledge training were associated with higher vaccination rates. Conversely, vaccine hesitancy was caused by a perceived lack of physical need, uncertainty about vaccination requirements, and fear of vaccination.Conclusion: This study provided population-based estimates of COVID-19 vaccine uptake intention among mainland Chinese nursing students and interns. Factors such as age, education, vaccine knowledge, and attitudes influence COVID-19 vaccine behaviour. Relevant authorities should understand the barriers to COVID-19 vaccination from knowledge, attitude and practice, which is significant for formulating effective response strategies in future global public health crises.Graphical Abstract: Keywords: COVID-19, vaccine, knowledge, attitudes, practice, nursing students and interns

Published
2023

24. Comparison of $pp$ and $p \bar{p}$ differential elastic cross sections and observation of the exchange of a colorless $C$-odd gluonic compound

Author

Abazov, V. M., Abbott, B., Acharya, B. S., Adams, M., Adams, T., Agnew, J. P., Alexeev, G. D., Alkhazov, G., Alton, A., Alves, G. A., Antchev, G., Askew, A., Aspell, P., Jesus, A. C. S. Assis, Atanassov, I., Atkins, S., Augsten, K., Aushev, V., Aushev, Y., Avati, V., Avila, C., Badaud, F., Baechler, J., Bagby, L., Barrera, C. Baldenegro, Baldin, B., Bandurin, D. V., Banerjee, S., Barberis, E., Baringer, P., Barreto, J., Bartlett, J. F., Bassler, U., Bazterra, V., Bean, A., Begalli, M., Bellantoni, L., Berardi, V., Beri, S. B., Bernardi, G., Bernhard, R., Berretti, M., Bertram, I., Besanccon, M., Beuselinck, R., Bhat, P. C., Bhatia, S., Bhatnagar, V., Blazey, G., Blessing, S., Bloom, K., Boehnlein, A., Boline, D., Boos, E. E., Borchsh, V., Borissov, G., Borysova, M., Bossini, E., Bottigli, U., Bozzo, M., Brandt, A., Brandt, O., Brochmann, M., Brock, R., Bross, A., Brown, D., Bu, X. B., Buehler, M., Buescher, V., Bunichev, V., Burdin, S., Burkhardt, H., Buszello, C. P., Cafagna, F. S., Camacho-P'erez, E., Carvahlo, W., Casey, B. C. K., Castilla-Valdez, H., Catanesi, M. G., Caughron, S., Chakrabarti, S., Chan, K. M., Chandra, A., Chapon, E., Chen, G., Cho, S. W., Choi, S., Choudhary, B., Cihangir, S., Claes, D., Clutter, J., Cooke, M., Cooper, W. E., Corcoran, M., Couderc, F., Cousinou, M. -C., Csan'ad, M., Cs"orgHo, T., Cuth, J., Cutts, D., Das, A., Davies, G., Deile, M., de Jong, S. J., De La Cruz-Burelo, E., De Leonardis, F., D'eliot, F., Demina, R., Denisov, D., Denisov, S. P., Desai, S., Deterre, C., DeVaughan, K., Diehl, H. T., Diesburg, M., Ding, P. F., Dominguez, A., Doubek, M., Drutskoy, A., Druzhkin, D., Dubey, A., Dudko, L. V., Duperrin, A., Dutt, S., Eads, M., Edmunds, D., Eggert, K., Ellison, J., Elvira, V. D., Enari, Y., Eremin, V., Evans, H., Evdokimov, A., Evdokimov, V. N., Faur'e, A., Feng, L., Ferbel, T., Ferro, F., Fiedler, F., Fiergolski, A., Filthaut, F., Fisher, W., Fisk, H. E., Forthomme, L., Fortner, M., Fox, H., Franc, J., Fuess, S., Garbincius, P. H., Garcia, F., Garcia-Bellido, A., Garc'ia-Gonz'alez, J. A., Gavrilov, V., Geng, W., Georgiev, V., Gerber, C. E., Gershtein, Y., Giani, S., Ginther, G., Gogota, O., Golovanov, G., Grannis, P. D., Greder, S., Greenlee, H., Grenier, G., Gris, Ph., Grivaz, J. -F., Grohsjean, A., Gr"unendahl, S., Gr"unewald, M. W., Grzanka, L., Guillemin, T., Gutierrez, G., Gutierrez, P., Haley, J., Hammerbauer, J., Han, L., Harder, K., Harel, A., Hauptman, J. M., Hays, J., Head, T., Hebbeker, T., Hedin, D., Hegab, H., Heinson, A. P., Heintz, U., Hensel, C., La Cruz, I. Heredia-De, Herner, K., Hesketh, G., Hildreth, M. D., Hirosky, R., Hoang, T., Hobbs, J. D., Hoeneisen, B., Hogan, J., Hohlfeld, M., Holzbauer, J. L., Howley, I., Hubacek, Z., Hynek, V., Iashvili, I., Ilchenko, Y., Illingworth, R., Isidori, T., Ito, A. S., Ivanchenko, V., Jabeen, S., Jaffr'e, M., Janda, M., Jayasinghe, A., Jeong, M. S., Jesik, R., Jiang, P., Johns, K., Johnson, E., Johnson, M., Jonckheere, A., Jonsson, P., Joshi, J., Jung, A. W., Juste, A., Kajfasz, E., Karev, A., Karmanov, D., Kavspar, J., Katsanos, I., Kaur, M., Kaynak, B., Kehoe, R., Kermiche, S., Khalatyan, N., Khanov, A., Kharchilava, A., Kharzheev, Y. N., Kiselevich, I., Kohli, J. M., Kopal, J., Kozelov, A. V., Kraus, J., Kumar, A., Kundr'at, V., Kupco, A., Kurvca, T., Kuzmin, V. A., Lami, S., Lammers, S., Latino, G., Lebrun, P., Lee, H. S., Lee, S. W., Lee, W. M., Le, X., Lellouch, J., Li, D., Li, H., Li, L., Li, Q. Z., Lim, J. K., Lincoln, D., Lindsey, C., Linhart, R., Linnemann, J., Lipaev, V. V., Lipton, R., Liu, H., Liu, Y., Lobodenko, A., Lokajicek, M., Lokaj'ivcek, M. V., de Sa, R. Lopes, Losurdo, L., Rodr'iguez, F. Lucas, Luna-Garcia, R., Lyon, A. L., Maciel, A. K. A., Macr'i, M., Madar, R., na-Villalba, R. Maga, Malawski, M., Malbouisson, H. B., Malik, S., Malyshev, V. L., Mansour, J., Mart'inez-Ortega, J., McCarthy, R., McGivern, C. L., Meijer, M. M., Melnitchouk, A., Menezes, D., Mercadante, P. G., Merkin, M., Meyer, A., Meyer, J., Miconi, F., Minafra, N., Minutoli, S., Molina, J., Mondal, N. K., Da Motta, H., Mulhearn, M., Mundim, L., Naaranoja, T., Nagy, E., Narain, M., Nayyar, R., Neal, H. A., Negret, J. P., Nemes, F., Neustroev, P., Nguyen, H. T., Niewiadomski, H., Nov'ak, T., Nunnemann, T., Oguri, V., Oliveri, E., Oljemark, F., Orduna, J., Oriunno, M., Osman, N., "Osterberg, K., Pal, A., Palazzi, P., Parashar, N., Parihar, V., Park, S. K., Partridge, R., Parua, N., Pasechnik, R., Passaro, V., Patwa, A., Penning, B., Perfilov, M., Peroutka, Z., Peters, Y., Petridis, K., Petrillo, G., P'etroff, P., Pleier, M. -A., Podstavkov, V. M., Popov, A. V., Da Silva, W. L. Prado, Prewitt, M., Price, D., Proch'azka, J., Prokopenko, N., Qian, J., Quadt, A., Quinn, B., Quinto, M., Raben, T. G., Radermacher, E., Rangel, M., Radicioni, E., Ratoff, P. N., Ravotti, F., Razumov, I., Ripp-Baudot, I., Rizatdinova, F., Robutti, E., Rodrigues, R. F., Rominsky, M., Ross, A., Royon, C., Rubinov, P., Ruchti, R., Ruggiero, G., Saarikko, H., Sajot, G., Samoylenko, V. D., S'anchez-Hern'andez, A., Sanders, M. P., Santoro, A., Santos, A. S., Savage, G., Savitskyi, M., Sawyer, L., Scanlon, T., Schamberger, R. D., Scheglov, Y., Schellman, H., Schott, M., Schwanenberger, C., Schwienhorst, R., Scribano, A., Sekaric, J., Severini, H., Shabalina, E., Shary, V., Shaw, S., Shchukin, A. A., Shkola, O., Simak, V., Siroky, J., Skubic, P., Slattery, P., Smajek, J., Snoeys, W., Snow, G. R., Snow, J., Snyder, S., S"oldner-Rembold, S., Sonnenschein, L., Soustruznik, K., Stark, J., Stefaniuk, N., Stefanovitch, R., Ster, A., Stoyanova, D. A., Strauss, M., Suter, L., Svoisky, P., Szanyi, I., Sziklai, J., Taylor, C., Tcherniaev, E., Titov, M., Tokmenin, V. V., Tsai, Y. -T., Tsybychev, D., Tuchming, B., Tully, C., Turini, N., Urban, O., Uvarov, L., Uvarov, S., Uzunyan, S., Vacek, V., Van Kooten, R., van Leeuwen, W. M., Varelas, N., Varnes, E. W., Vasilyev, I. A., Vavroch, O., Verkheev, A. Y., Vertogradov, L. S., Verzocchi, M., Vesterinen, M., Vilanova, D., Vokac, P., Wahl, H. D., Wang, C., Wang, M. H. L. S., Warchol, J., Watts, G., Wayne, M., Weichert, J., Welti, J., Welty-Rieger, L., Williams, J., Williams, M. R. J., Wilson, G. W., Wobisch, M., Wood, D. R., Wyatt, T. R., Xie, Y., Yamada, R., Yang, S., Yasuda, T., Yatsunenko, Y. A., Ye, W., Ye, Z., Yin, H., Yip, K., Youn, S. W., Yu, J. M., Zennamo, J., Zhao, T. G., Zhou, B., Zhu, J., Zich, J., Zielinski, K., Zielinski, M., Zieminska, D., and Zivkovic, L.

Subjects
High Energy Physics - Experiment
Abstract

We describe an analysis comparing the $p\bar{p}$ elastic cross section as measured by the D0 Collaboration at a center-of-mass energy of 1.96 TeV to that in $pp$ collisions as measured by the TOTEM Collaboration at 2.76, 7, 8, and 13 TeV using a model-independent approach. The TOTEM cross sections extrapolated to a center-of-mass energy of $\sqrt{s} =$ 1.96 TeV are compared with the D0 measurement in the region of the diffractive minimum and the second maximum of the $pp$ cross section. The two data sets disagree at the 3.4$\sigma$ level and thus provide evidence for the $t$-channel exchange of a colorless, $C$-odd gluonic compound, also known as the odderon. We combine these results with a TOTEM analysis of the same $C$-odd exchange based on the total cross section and the ratio of the real to imaginary parts of the forward elastic scattering amplitude in $pp$ scattering. The combined significance of these results is larger than 5$\sigma$ and is interpreted as the first observation of the exchange of a colorless, $C$-odd gluonic compound., Comment: D0 and TOTEM Collaborations

Published
2020
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25. A Preliminary Study on Sympathetic Skin Response in Acute Ischemic Cerebrovascular Disease

Author

Chen W, Chen Y, Ye W, and Wang T

Subjects
acute ischemic cerebrovascular disease, aicvd, sympathetic skin response, ssr, autonomic nervous system, ans, Medicine (General), R5-920
Abstract

Wenhong Chen,1 Yunping Chen,2 Wenjuan Ye,3 Ting Wang1 1Department of Pediatric Neurology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 3Department of Pediatric, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Ting Wang, Department of Pediatric Neurology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, 745 Wuluo Road, Hongshan District, Wuhan, Hubei, People’s Republic of China, Tel +86-27-87169308, Email 67722896@qq.comPurpose: The study aims to identify the characteristics of SSR in patients with AICVD and their correlation with clinical presentations.Methods: SSR of the upper limbs, the National Institute of Health stroke scale (NIHSS), the Barthel index (BI), the Essen stroke risk score (ESRS), and imaging examinations, was evaluated in 30 healthy subjects and 66 patients with AICVD. All results were recorded and analyzed via Statistical Package for the Social Sciences (SPSS 22.0) software. t-test and Spearman rank correlation were used.Results: Compared to the control group, SSR of upper limbs in patients with AICVD showed prolonged latency, reduced amplitude, and disappeared waveform (p=0.000, p=0.015, p=0.004), No statistically significant difference was observed between the affected side and the healthy side (p=0.068, p=0.661). In the case group, the higher the abnormal rate of SSR, the more severe the neurological impairment (NIHSS and ADL scores) and the worse the long-term prognosis. Specific results are as follows: Firstly, the total abnormality rate of SSR, prolonged SSR latency were positively related to the NIHSS, also the ESRS (r=0.347, p=0.004; r=0.437, p< 0.001), (r=0.371, p=0.005; r=0.433, p=0.001), the reduced amplitude was positively related to the NIHSS (r=0.341, p=0.012) while the disappeared waveform was positively related to the ESRS (r=0.299, p=0.015); Secondly, the total abnormality rate of SSR, prolonged SSR latency and reduced amplitude were negatively related to the BI (r=− 0.346, p=0.004) (r=− 0.426, p=0.001) (r=− 0.316, p=0.020).Conclusion: There may be inhibition of sympathetic reflex activity in patients with AICVD, SSR abnormality rate in patients with AICVD may be correlated with the degree of neurological impairment and long-term prognosis.Keywords: acute ischemic cerebrovascular disease, AICVD, sympathetic skin response, SSR, autonomic nervous system, ANS

Published
2023

28. POS0257 MOLECULAR CLASSIFICATION OF SALIVARY GLANDS IN PRIMARY SJOGREN’S SYNDROME

Author

Xu, H., primary, Wang, X., additional, Jing, L., additional, Ying, S., additional, Hong, J., additional, Cheng, H., additional, Wang, P., additional, He, Y., additional, Zhang, J., additional, Ye, W., additional, Zhu, X., additional, Zhu, C., additional, Yang, L., additional, LI, Z., additional, Lin, S., additional, Chen, D., additional, Wu, X., additional, Xie, Z., additional, and Wu, J., additional

Published
2024
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29. Loss of Anthropometry-Lipids Relationship in Obese Adults: A Cross-Sectional Study in Southern China

Author

Huang W, Feng R, Xu X, Ma M, Chen J, Wang J, Hu Z, Du S, and Ye W

Subjects
anthropometry, lipid profile, epidemiology, Infectious and parasitic diseases, RC109-216
Abstract

Wuqing Huang,1,&ast; Ruimei Feng,1,&ast; Xin Xu,1,&ast; Mingyang Ma,1 Jun Chen,1 Junzhuo Wang,1 Zhijian Hu,1,2 Shanshan Du,1 Weimin Ye1– 3 1Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, People’s Republic of China; 3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden&ast;These authors contributed equally to this workCorrespondence: Weimin Ye; Shanshan Du, Fujian Medical University, No. 1, Xue Yuan Road, University Town, Fuzhou City, Fujian Province, 350108, People’s Republic of China, Tel +86 591 2286 2023, Fax +86 591 2286 2510, Email ywm@fjmu.edu.cn; dushanshan1007@163.comBackground: Emerging data suggest that the interpretation of the association between obesity and lipids appears to be oversimplified. This study aimed to quantify the complex relationships between anthropometric indices and lipid profile.Methods: This is a cross-sectional study including 9620 participants in Southern China. Anthropometric indices included the indices of general obesity (ie, body mass index (BMI)) and central obesity (ie, waist circumference (WC) and waist-to-hip ratio (WHR)). Lipids included low-density lipoprotein cholesterol (LDLc) and atherogenic lipids (ie, high-density lipoprotein cholesterol (HDLc), triglycerides (TG) and TG/HDLc ratio). LOESS regression and general linear model were the main statistical methods.Results: Almost all associations between anthropometric indices and lipids were lost in obese adults. The loss of association occurred quicker with LDLc than that with atherogenic lipids; the break point for the association loss was at BMI of 24 kg/m2 with LDLc (Slope Below break-point = 1.81, P< 0.001; Slope Above break-point = 0.29, P=0.121), while at 28 kg/m2 with HDLC (Slope Below break-point = − 1.41, P< 0.001; Slope Above break-point = 0.07, P=0.666) or TG (Slope Below break-point = 4.96, P< 0.001; Slope Above break-point = 2.93, P=0.01), and at 30 kg/m2 with TG/HDLc ratio (Slope Below break-point = 0.15, P< 0.001; Slope Above break-point= 0.01, P=0.936), respectively. Similar relationships were found for WC and WHR. Besides, the presence of other metabolic disorders contributed to the loss of anthropometry-lipids relationships, for example, the BMI-LDLc association attenuated to null in both obese adults and non-obese population but with more than one other metabolic disorders.Conclusion: The relationships were lost between anthropometric indices and lipids in obese adults with different break points across different lipids, which appeared to be dependent on metabolic status.Keywords: anthropometry, lipid profile, epidemiology

Published
2023

30. Moxibustion as an Adjuvant Therapy for Cancer Pain: A Systematic Review and Meta-Analysis

Author

Li Y, Hong E, Ye W, and You J

Subjects
moxibustion, cancer pain, systematic review, meta-analysis, Medicine (General), R5-920
Abstract

Yan Li,1,&ast; Ensi Hong,1,2,&ast; Wenguo Ye,2 Jianyu You1 1Jiangxi University of Chinese Medicine, Nanchang, People’s Republic of China; 2The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wenguo Ye, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, People’s Republic of China, Email 648957697@qq.com Jianyu You, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, People’s Republic of China, Email youjytcm@163.comPurpose: Pain is one of the most common and feared symptoms among cancer patients. Unrelieved pain denies patients comfort and greatly affects their overall quality of life. Moxibustion is commonly used to manage chronic pain. However, its efficacy on cancer pain remains inconclusive. This study aimed to evaluate the efficacy of moxibustion for cancer pain.Methods: We searched seven databases to obtain articles about moxibustion combined with pharmacotherapy for cancer pain published before November 2022. All data extraction was carried out independently by two investigators. RevMan 5.4 software was used for data analysis.Results: A total of ten trials involving 999 cases were included. The results of the meta-analysis revealed that moxibustion combined with pharmacotherapy was significantly better than drug therapy alone in improving pain relief rate (RR =1.16, 95% CI = [1.04, 1.30], P = 0.01), reducing pain scores (SMD = − 1.43, 95% CI = [− 2.09, − 0.77], P < 0.0001), Shortening the onset of analgesia (MD = − 12.07, 95% CI = [− 12.91, − 11.22], P < 0.00001), prolonging the duration of analgesia (MD = 3.69, 95% CI = [3.21, 4.18], P < 0.00001), and improving quality of life (SMD = 2.48, 95% CI = [0.67, 4.29], P = 0.007). In addition, moxibustion combined with pharmacotherapy can effectively reduce adverse reactions of drugs (RR =0.35, 95% CI = [0.21, 0.57], P < 0.0001).Conclusion: The evidence in this review supports moxibustion as an effective adjuvant therapy for cancer pain management. However, high-quality RCTs are needed to further confirm these findings.Registration Number: PROSPERO CRD42022370942.Keywords: moxibustion, cancer pain, systematic review, meta-analysis

Published
2023

31. Real-World Treatment Patterns and Outcomes Among Patients with Episodic Migraine in China: Results from the Adelphi Migraine Disease Specific Programme&trade

Author

Zhao H, Xiao Z, Zhang L, Ford J, Zhong S, Ye W, Li J, Tockhorn-Heidenreich A, Cotton S, and Chen C

Subjects
episodic migraine, clinical practice, patient-reported outcomes, real-world, disease burden, Medicine (General), R5-920
Abstract

Hongru Zhao,1 Zheman Xiao,2 Lei Zhang,3 Janet Ford,4 Shiying Zhong,3 Wenyu Ye,4 Jinnan Li,3 Antje Tockhorn-Heidenreich,4 Sarah Cotton,5 Chunfu Chen6,7 1The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Renmin Hospital of Wuhan University, Wuhan, People’s Republic of China; 3Eli Lilly China, Shanghai, People’s Republic of China; 4Eli Lilly and Company, Indianapolis, IN, USA; 5Adelphi Real World, Bollington, UK; 6Department of Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University Jinan, Jinan, People’s Republic of China; 7Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of ChinaCorrespondence: Chunfu Chen, Department of Neurology, Shandong Provincial Hospital, &num; 324 Jingwuweiqi, Road, Shandong, 250021, People’s Republic of China, Tel +86 13853153248, Email chencf301@163.comObjective: This study assessed treatment patterns, disease burden, outcomes, and unmet needs among patients with episodic migraine (EM) in China using Adelphi Migraine Disease Specific Programme™ (DSP) real-world data.Background: Migraine is a prevalent and debilitating neurological disorder which presents a major public health burden globally. Research on characteristics, disease burden, and treatment patterns in EM patients in China is limited.Methods: Data were drawn from an existing data set Adelphi Migraine DSP, a point-in-time survey conducted in China (January-June 2014). Internists/neurologists completed patient record forms for the next 9 patients who consulted them in clinical practice; these same patients completed the ‘patient self-completion questionnaires’. Descriptive analyses were used to assess key variables: patient demographics, treatment patterns (current acute and preventive medication [AM/PM]), effectiveness, issues with existing treatment, Migraine Disability Assessment (MIDAS) scores, and Work Productivity and Activity Impairment scores.Results: Total of 125 internists/neurologists provided data on 1113 patients with EM (headache days/month < 15). Mean (standard deviation [SD]) age was 43.8 (13.1) years; mean (SD) number of migraine days/month was 3.2 (1.7). AM was prescribed in 86.1% of patients (non-steroid anti-inflammatory drugs [NSAIDs]: 62.7%; triptans: 7.7%), PM in 38.5%, and both in 24.9% of patients. Approximately 55% of patients experienced ≥ 1 issue with their current AM or PM. Migraine-related symptoms (including nausea, photophobia, and phonophobia) were fully controlled in < 50% of patients receiving NSAIDs (21.7– 38.4%) or triptans (32.4– 43.5%). Insufficient response to current AM (migraine headache fully resolved within 2 hours in ≤ 3/5 attacks) was reported by 42.5% of patients. Mild-to-severe disability was reported by 36.8% of patients with a mean (SD) MIDAS score of 5.8 (7.3). Overall, 58.0% of work time was impaired (including time missed and impairment while working).Conclusion: This analysis suggests, despite existing treatment options, disease burden and unmet medical needs remain substantial in Chinese patients with EM.Keywords: episodic migraine, clinical practice, patient-reported outcomes, real-world, disease burden

Published
2023

41. Pulsed Iron Line Emission from the First Galactic Ultraluminous X-Ray Pulsar Swift J0243.6+6124

Author

Xiao, Y. X., primary, Xu, Y. J., additional, Ge, M. Y., additional, Lu, F. J., additional, Zhang, S. N., additional, Zhang, S., additional, Tao, L., additional, Qu, J. L., additional, Wang, P. J., additional, Kong, L. D., additional, Tuo, Y. L., additional, You, Y., additional, Zhao, S. J., additional, Peng, J. Q., additional, Du, Y. F., additional, Zhang, Y. H., additional, and Ye, W. T., additional

Published
2024
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44. Graph Networks as a Universal Machine Learning Framework for Molecules and Crystals

Author

Chen, C, Ye, W, Zuo, Y, Zheng, C, and Ong, SP

Subjects
cond-mat.mtrl-sci, physics.comp-ph, Materials, Chemical Sciences, Engineering
Abstract

Graph networks are a new machine learning (ML) paradigm that supports both relational reasoning and combinatorial generalization. Here, we develop universal MatErials Graph Network (MEGNet) models for accurate property prediction in both molecules and crystals. We demonstrate that the MEGNet models outperform prior ML models such as the SchNet in 11 out of 13 properties of the QM9 molecule data set. Similarly, we show that MEGNet models trained on 60 000 crystals in the Materials Project substantially outperform prior ML models in the prediction of the formation energies, band gaps, and elastic moduli of crystals, achieving better than density functional theory accuracy over a much larger data set. We present two new strategies to address data limitations common in materials science and chemistry. First, we demonstrate a physically intuitive approach to unify four separate molecular MEGNet models for the internal energy at 0 K and room temperature, enthalpy, and Gibbs free energy into a single free energy MEGNet model by incorporating the temperature, pressure, and entropy as global state inputs. Second, we show that the learned element embeddings in MEGNet models encode periodic chemical trends and can be transfer-learned from a property model trained on a larger data set (formation energies) to improve property models with smaller amounts of data (band gaps and elastic moduli).

Published
2019

45. Treatment Patterns for Calcitonin Gene-Related Peptide Monoclonal Antibodies Including Galcanezumab versus Conventional Preventive Treatments for Migraine: A Retrospective US Claims Study

Author

Varnado OJ, Manjelievskaia J, Ye W, Perry A, Schuh K, and Wenzel R

Subjects
cgrp, persistence, adherence, discontinuation, switch., Medicine (General), R5-920
Abstract

Oralee J Varnado,1 Janna Manjelievskaia,2 Wenyu Ye,1 Allison Perry,2 Kory Schuh,1 Richard Wenzel1 1Value, Evidence, and Outcomes, Eli Lilly and Company, Indianapolis, IN, USA; 2Watson Health Life Sciences, Research & Analytics, IBM Watson Health, Cambridge, MA, USACorrespondence: Oralee J Varnado, Value, Evidence, and Outcomes, Eli Lilly and Company, Lilly Corporate Center, 893 Delaware Street, Indianapolis, IN, 46285, USA, Tel +1 317 277 0599, Email varnado_oralee_johnson@lilly.comBackground: Most conventional, oral, preventive treatments for migraine are non-specific and ∼ 50% of patients discontinue them within six months. In 2018, the Food and Drug Administration approved three preventive migraine treatments: monoclonal antibodies (mAb) targeting the calcitonin gene-related peptide (CGRP) pathway implicated in migraine; galcanezumab and fremanezumab which target CGRP ligand; and erenumab which targets CGRP receptor. Real-world treatment patterns for CGRP mAb are limited.Purpose: To compare real-world treatment patterns for CGRP mAb, specifically galcanezumab versus standard-of-care (SOC) migraine preventive treatments.Patients and methods: This retrospective, observational study included 12-month baseline and 6- and 12-month follow-up analyses using IBM® MarketScan® databases. Patients identified were aged ≥ 18 years with ≥ 1 claim (first claim=index) for CGRP mAb (erenumab, fremanezumab, or galcanezumab) or SOC preventives (eg, antiepileptics, beta-blockers, antidepressants, or onabotulinumtoxinA) as index drugs between May/01/2018 and June/30/2019. Propensity score matching was used to address confounding by observed covariates. Outcomes analyzed included proportion of days covered (PDC), persistence (≤ 60-day gap), and first non-index drug switch. Descriptive, chi-square (categorical), and t-test (continuous) analyses were conducted.Results: The study included 3082 (CGRP mAb versus SOC) and 421 (galcanezumab versus SOC) matched patient pairs with 12-month follow-up. Mean age across cohorts ranged 43.2– 44.4 years (females: 85.7– 88.6%). Compared with SOC, the CGRP mAb cohort had higher mean persistence (212.5 vs 131.9 days), adherence (PDC: 55.1% vs 35.2%), and more patients were adherent with PDC ≥ 80% (32.7% vs 18.7%) (all p < 0.001). During 12-month follow-up, fewer patients discontinued CGRP mAb versus SOC (58.8% vs 77.6%, p < 0.001). Galcanezumab versus SOC comparisons yielded similar results. In the CGRP mAb cohort, most switchers (28.3%) used galcanezumab as subsequent treatment. Largely similar results were observed for 6-month follow-up cohorts.Conclusion: Patients on CGRP mAb and specifically galcanezumab showed higher adherence and persistence than patients on SOC migraine preventive treatments.Keywords: CGRP, persistence, adherence, discontinuation, switch

Published
2022

46. Harnessing the Materials Project for machine-learning and accelerated discovery

Author

Ye, W, Chen, C, Dwaraknath, S, Jain, A, Ong, SP, and Persson, KA

Subjects
defects, elastic properties, Networking and Information Technology R&D, Bioengineering, Applied Physics, Materials Engineering, Mechanical Engineering, Macromolecular and Materials Chemistry
Abstract

Improvements in computational resources over the last decade are enabling a new era of computational prediction and design of novel materials. The resulting resources are databases such as the Materials Project (www.materialsproject.org), which is harnessing the power of supercomputing together with state-of-the-art quantum mechanical theory to compute the properties of all known inorganic materials, to design novel materials, and to make the data available for free to the community, together with online analysis and design algorithms. The current release contains data derived from quantum mechanical calculations for more than 70,000 materials and millions of associated materials properties. The software infrastructure carries out thousands of calculations per week, enabling screening and predictions for both novel solids as well as molecular species with targeted properties. As the rapid growth of accessible computed materials properties continues, the next frontier is harnessing that information for automated learning and accelerated discovery. In this article, we highlight some of the emerging and exciting efforts, and successes, as well as current challenges using descriptor-based and machine-learning methods for data-accelerated materials design.

Published
2018

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