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Bingyan Ren,1,* Hanbin Ye,2,* Wenyuan Shan,3 Xuelei Tao,4 Zi Ye2 1Department of Emergency, the Second Affiliated Hospital of Nantong University, Nantong First People’s Hospital, Nantong, People’s Republic of China; 2Department of Neurosurgery, the Second Affiliated Hospital of Nantong University, Nantong First People’s Hospital, Nantong, People’s Republic of China; 3Department of Neurosurgery, the Fourth Affiliated Hospital of Nantong University, Nantong Fourth People’s Hospital, Nantong, People’s Republic of China; 4Department of Neurosurgery, Nantong Second People’s Hospital, Nantong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zi Ye, Department of Neurosurgery, the Second Affiliated Hospital of Nantong University, Nantong First People’s Hospital, No. 6 of North of Haierxiang Road, Hepingqiao District, Nantong, 216000, People’s Republic of China, Email yezileafff@126.com Xuelei Tao, Department of Neurosurgery, Nantong Second People’s Hospital, No. 43 of Xinglong Road, Nantong, 100730, People’s Republic of China, Email xueleitaonshxzh@126.comObjective: To examine the impact of hyperbaric oxygen intervention on oxidative stress and nerve growth factor in patients with craniocerebral injury.Methods: Using the random number table method, 40 patients with craniocerebral injury who were treated at the First People’s Hospital of Nantong were randomly assigned to either the control group or the hyperbaric oxygen group, with 20 patients in each group. The control group received routine intervention for clinical traumatic brain injury, while the hyperbaric oxygen group received additional hyperbaric oxygen intervention during the 7 to 30 days of routine intervention. Indicators of oxidative stress and nerve growth factor levels were compared between the two groups at the time of admission and 30 days after therapy.Results: The serum levels of superoxide dismutase, endothelium-deri