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5. Chemotherapy (doublet or triplet) plus targeted therapy by RAS status as conversion therapy in colorectal cancer patients with initially unresectable liver-only metastases. The UNICANCER PRODIGE-14 randomised clinical trial

Author

Ychou, Marc, Rivoire, Michel, Thezenas, Simon, Guimbaud, Rosine, Ghiringhelli, Francois, Mercier-Blas, Anne, Mineur, Laurent, Francois, Eric, Khemissa, Faiza, Chauvenet, Marion, Kianmanesh, Reza, Fonck, Marianne, Houyau, Philippe, Aparicio, Thomas, Galais, Marie-Pierre, Audemar, Franck, Assenat, Eric, Lopez-Crapez, Evelyne, Jouffroy, Claire, Adenis, Antoine, Adam, René, and Bouché, Olivier

Published
2022
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10. Sorafenib Plus Irinotecan Combination in Patients With RAS-mutated Metastatic Colorectal Cancer Refractory To Standard Combined Chemotherapies: A Multicenter, Randomized Phase 2 Trial (NEXIRI-2/PRODIGE 27)

Author

Samalin, Emmanuelle, Fouchardière, Christelle de la, Thézenas, Simon, Boige, Valérie, Senellart, Hélène, Guimbaud, Rosine, Taïeb, Julien, François, Eric, Galais, Marie-Pierre, Lièvre, Astrid, Seitz, Jean-François, Metges, Jean-Philippe, Bouché, Olivier, Boissière-Michot, Florence, Lopez-Crapez, Evelyne, Bibeau, Frédéric, Ho-Pun-Cheung, Alexandre, Ychou, Marc, Adenis, Antoine, Di Fiore, Frédéric, and Mazard, Thibault

Published
2020
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19. Prospective validation of a lymphocyte infiltration prognostic test in stage III colon cancer patients treated with adjuvant FOLFOX

Author

Thaler, Josef, Greil, Richard, Gaenzer, Johannes, Eisterer, Wolfgang, Tschmelitsch, Joerg, Keil, Felix, Samonigg, Hellmut, Zabernigg, August, Schmid, Franz, Steger, Günther, Steinacher, Robert, Andel, Johannes, Jagdt, Björn, Lang, Alois, Fridrik, Michael, Függer, Reinhold, Hofbauer, Friedrich, Woell, Ewald, Geissler, Dietmar, Lenauer, Alfred, Prager, Manfred, D'Haens, Geert, Demolin, Gauthier, Kerger, Joseph, Deboever, Guido, Ghillebert, Gilbert, Polus, Marc, Van Cutsem, Eric, Kalantari, Hassan Rezaie, Delaunoit, Thierry, Goeminne, Jean Charles, Peeters, Marc, Vergauwe, Philippe, Houbiers, Ghislain, Humblet, Yves, Janssens, Jos, Schrijvers, Dirk, Vanderstraeten, Erik, Van Laethem, Jean-Luc, Vermorken, Jan, Van Daele, Daniel, Ferrante, Michel, Forget, Frederic, Hendlisz, Alain, Yilmaz, Mette, Nielsen, Svend Erik, Vestermark, Lene, Larsen, Jim, Zawadi, Mohamed-Ayman, Bouche, Olivier, Mineur, Laurent, Bennouna-Louridi, Jaafar, Dourthe, Louis Marie, Ychou, Marc, Boucher, Eveline, Taieb, Julien, Pezet, Denis, Desseigne, Francoise, Ducreux, Michel, Texereau, Patrick, Miglianico, Laurent, Rougier, Philippe, Fratte, Serge, Levache, Charles-Briac, Merrouche, Yacine, Ellis, Stephen, Locher, Christophe, Ramee, Jean-Francois, Garnier, Claire, Viret, Frederic, Chauffert, Bruno, Cojean-Zelek, Isabelle, Michel, Pierre, Lecaille, Cedric, Borel, Christian, Seitz, Jean-Francois, Smith, Denis, Lombard-Bohas, Catherine, Andre, Thierry, Gornet, Jean-Marc, Fein, Francine, Coulon-Sfairi, Marie-Aude, Kaminsky, Marie-Christine, Lagasse, Jean-Paul, Luet, Dominique, Etienne, Pierre-Luc, Gasmi, Mohamed, Vanoli, Andre, Nguyen, Suzanne, Aparicio, Thomas, Perrier, Hervé, Stremsdoerfer, Noel, Laplaige, Philippe, Arsene, Dominique, Auby, Dominique, Bedenne, Laurent, Coriat, Romain, Denis, Bernard, Geoffroy, Patrick, Piot, Gilles, Becouarn, Yves, Bordes, Gilbert, Deplanque, Gael, Dupuis, Olivier, Fruge, Frederic, Guimbaud, Rosine, Lecomte, Thierry, Lledo, Gérard, Sobhani, Iradej, Asnacios, Amani, Azzedine, Ahmed, Desauw, Christophe, Galais, Marie-Pierre, Gargot, Dany, Lam, You-Heng, Abakar-Mahamat, Abakar, Berdah, Jean-Francois, Catteau, Sylviane, Clavero-Fabri, Marie-Christine, Codoul, Jean-Francois, Legoux, Jean-Louis, Goldfain, Denis, Guichard, Pierre, Verge, Denis Pere, Provencal, Jocelyne, Vedrenne, Bruno, Brezault-Bonnet, Catherine, Cleau, Denis, Desir, Jean-Paul, Fallik, David, Garcia, Bruno, Gaspard, Marie-Hélène, Genet, Dominique, Hartwig, Johannes, Krummel, Yves, Budnik, Tamara Matysiak, Palascak-Juif, Vanessa, Randrianarivelo, Harizo, Rinaldi, Yves, Aleba, Albert, Darut-Jouve, Ariane, de Gramont, Aimery, Hamon, Herve, Wendehenne, Frederic, Matzdorff, Axel, Stahl, Michael Konrad, Schepp, Wolfgang, Burk, Martin, Mueller, Lothar, Folprecht, Gunnar, Geissler, Michael, Mantovani-Loeffler, Luisa, Hoehler, Thomas, Asperger, Walter, Kroening, Hendrik, von Weikersthal, Ludwig Fischer, Fuxius, Stefan, Groschek, Matthias, Meiler, Johannes, Trarbach, Tanja, Rauh, Jacqueline, Ziegenhagen, Nicolas, Kretzschmar, Albrecht, Graeven, Ullrich, Nusch, Arnd, von Wichert, Goetz, Hofheinz, Ralf-Dieter, Kleber, Gerhard, Schmidt, Karl-Heinz, Vehling-Kaiser, Ursula, Baum, Claudia, Schuette, Jochen, Haag, Georg Martin, Holtkamp, Wilhelm, Potenberg, Jochen, Reiber, Tobias, Schliesser, Georg, Schmoll, Hans-Joachim, Schneider-Kappus, Wolfgang, Abenhardt, Wolfgang, Denzlinger, Claudio, Henning, Jan, Marxsen, Bartscht, Derigs, Hans Guenter, Lambertz, Helmut, Becker-Boost, Ingulf, Caca, Karel, Constantin, Christian, Decker, Thomas, Eschenburg, Henning, Gabius, Sigrun, Hebart, Holger, Hoffmeister, Albrecht, Horst, Heinz-August, Kremers, Stephan, Leithaeuser, Malte, Mueller, Sebastian, Wagner, Siegfried, Daum, Severin, Schlegel, Frank, Stauch, Martina, Heinemann, Volker, Maiello, Evaristo, Latini, Luciano, Zaniboni, Alberto, Amadori, Dino, Aprile, Giuseppe, Barni, Sandro, Mattioli, Rodolfo, Martoni, Andrea, Passalacqua, Rodolfo, Nicolini, Mario, Pasquini, Enzo, Rabbi, Carla, Aitini, Enrico, Ravaioli, Alberto, Barone, Carlo, Biasco, Guido, Tamberi, Stefano, Gambi, Angelo, Verusio, Claudio, Marzola, Marina, Lelli, Giorgio, Boni, Corrado, Cascinu, Stefano, Bidoli, Paolo, Vaghi, Massimo, Cruciani, Giorgio, Di Costanzo, Francesco, Sobrero, Alberto, Mini, Enrico, Petrioli, Roberto, Aglietta, Massimo, Alabiso, Oscar, Capuzzo, Federico, Falcone, Alfredo, Corsi, Domenico Cristi, Labianca, Roberto, Salvagni, Stefania, Chiara, Silvana, Ciuffreda, Libero, Ferraù, Francesco, Giuliani, Francesco, Lonardi, Sara, Gebbia, Nicola, Mantovani, Giovanni, Sanches, Evaristo, Mellidez, Juan Carlos, Santos, Pedro, Freire, Joao, Sarmento, Cristina, Costa, Luis, Pinto, Antonio Moreira, Barroso, Sergio, Santo, Jorge Espirito, Guedes, Fátima, Monteiro, Amélia, Sa, Anabela, Furtado, Irene, Salazar, Ramon, Aguilar, Enrique Aranda, Herrero, Fernando Rivera, Tabernero, Josep, Valera, Javier Sastre, Ayerbes, Manuel Valladares, Batlle, Jaime Feliu, Gil, Silvia, Esteve, Albert Abad, Garcia-Giron, Carlos, Vivanco, Guillermo Lopez, Salvia, Antonia Salud, Orduña, Vicente Alonso, Garcia, Ruth Vera, Gallego, Javier, Sureda, Bartomeu Massuti, Remon, Jordi, Safont Aguilera, Maria Jose, Nogueras, Luis Cirera, Merino, Bernado Queralt, Castro, Cristina Gravalos, de Prado, Purificacion Martinez, Pericay, Carlos Pijaume, Figueiras, Manuel Constenla, Jordan, Inmaculada Guasch, Gome Reina, Maria Jose, Garcia, Amelia Lopez-Ladron, Garcia-Ramos, Antonio Arrivi, Cervantes, Andres, Martos, Carlos Fernandez, Gaspar, Eugenio Marcuello, Montero, Ines Cabezas, Emperador, Pilar Escudero, Carbonero, Ana Leon, Castillo, Manuel Gallen, Garcia, Teresa Garcia, Lopez, Jose Garcia, Flores, Encarnacion Gonzalez, Morales, Monica Guillot, Muñoz, Marta Llanos, Martín, Ana López, Maurel, Joan, Camara, Juan Carlos, Garcia, Rosario Dueñas, Salgado, Mercedes, Busquier, Isabel Hernandez, Ruiz, Teresa Checa, Muñoa, Adelaida Lacasta, Aliguer, Miquel Nogue, de Taranco, Amalia Velasco Ortiz, Ureña, Miguel Mendez, Gaspa, Ferran Losa, Ponce, Jose Juan, Roig, Carlos Bosch, Jimenez, Pedro Valero, Brotons, Antonio Galan, Rodriguez, Santiago Albiol, Martinez, Jose Ales, Ruiz, Liliana Canosa, Ruiz, Margarita Centelles, Bridgewater, John, Glynne-Jones, Rob, Tahir, Saad, Hickish, Tamas, Cassidy, Jim, Samuel, Leslie, Emile, Jean-François, Julié, Catherine, Le Malicot, Karine, Lepage, Come, Dimet, Stéphanie, Boulagnon-Rombi, Camille, Allard, Marc-Antoine, Penault-Llorca, Frédérique, Bennouna, Jaafar, and Laurent-Puig, Pierre

Published
2017
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20. Individual Participant Data Network Meta-Analysis of Neoadjuvant Chemotherapy or Chemoradiotherapy in Esophageal or Gastroesophageal Junction Carcinoma

Author

Faron, Matthieu, Cheugoua-Zanetsie, Maurice, Tierney, Jayne, Thirion, Pierre, Nankivell, Matthew, Winter, Kathryn, Yang, Hong, Shapiro, Joel, Vernerey, Dewi, Smithers, B. Mark, Walsh, Thomas, Piessen, Guillaume, Nilsson, Magnus, Boonstra, Jurjen, Ychou, Marc, Law, Simon, Cunningham, David, de Vathaire, Florent, Stahl, Michael, Urba, Susan, Valmasoni, Michele, Williaume, Danièle, Thomas, Janine, Lordick, Florian, Tepper, Joel, Roth, Jack, Gebski, Val, Burmeister, Bryan, Paoletti, Xavier, van Sandick, Johanna, Fu, Jianhua, Pignon, Jean Pierre, Ducreux, Michel, Michiels, Stefan, Faron, Matthieu, Cheugoua-Zanetsie, Maurice, Tierney, Jayne, Thirion, Pierre, Nankivell, Matthew, Winter, Kathryn, Yang, Hong, Shapiro, Joel, Vernerey, Dewi, Smithers, B. Mark, Walsh, Thomas, Piessen, Guillaume, Nilsson, Magnus, Boonstra, Jurjen, Ychou, Marc, Law, Simon, Cunningham, David, de Vathaire, Florent, Stahl, Michael, Urba, Susan, Valmasoni, Michele, Williaume, Danièle, Thomas, Janine, Lordick, Florian, Tepper, Joel, Roth, Jack, Gebski, Val, Burmeister, Bryan, Paoletti, Xavier, van Sandick, Johanna, Fu, Jianhua, Pignon, Jean Pierre, Ducreux, Michel, and Michiels, Stefan

Abstract

PURPOSE: The optimal neoadjuvant treatment for resectable carcinoma of the thoracic esophagus (TE) or gastroesophageal junction (GEJ) remains a matter of debate. We performed an individual participant data (IPD) network meta-analysis (NMA) of randomized controlled trials (RCTs) to study the effect of chemotherapy or chemoradiotherapy, with a focus on tumor location and histology subgroups. PATIENTS AND METHODS: All, published or unpublished, RCTs closed to accrual before December 31, 2015 and having compared at least two of the following strategies were eligible: upfront surgery (S), chemotherapy followed by surgery (CS), and chemoradiotherapy followed by surgery (CRS). All analyses were conducted on IPD obtained from investigators. The primary end point was overall survival (OS). The IPD-NMA was analyzed by a one-step mixed-effect Cox model adjusted for age, sex, tumor location, and histology. The NMA was registered in PROSPERO (CRD42018107158). RESULTS: IPD were obtained for 26 of 35 RCTs (4,985 of 5,807 patients) corresponding to 12 comparisons for CS-S, 12 for CRS-S, and four for CRS-CS. CS and CRS led to increased OS when compared with S with hazard ratio (HR) = 0.86 (0.75 to 0.99), P = .03 and HR = 0.77 (0.68 to 0.87), P < .001 respectively. The NMA comparison of CRS versus CS for OS gave a HR of 0.90 (0.74 to 1.09), P = .27 (consistency P = .26, heterogeneity P = .0038). For CS versus S, a larger effect on OS was observed for GEJ versus TE tumors (P = .036). For the CRS versus S and CRS versus CS, a larger effect on OS was observed for women (P = .003, .012, respectively). CONCLUSION:Neoadjuvant chemotherapy and chemoradiotherapy were consistently better than S alone across histology, but with some variation in the magnitude of treatment effect by sex for CRS and tumor location for CS. A strong OS difference between CS and CRS was not identified.

Published
2023

23. Supplementary information from Circulating DNA as a Strong Multimarker Prognostic Tool for Metastatic Colorectal Cancer Patient Management Care

Author

El Messaoudi, Safia, primary, Mouliere, Florent, primary, Du Manoir, Stanislas, primary, Bascoul-Mollevi, Caroline, primary, Gillet, Brigitte, primary, Nouaille, Michelle, primary, Fiess, Catherine, primary, Crapez, Evelyne, primary, Bibeau, Frederic, primary, Theillet, Charles, primary, Mazard, Thibault, primary, Pezet, Denis, primary, Mathonnet, Muriel, primary, Ychou, Marc, primary, and Thierry, Alain R., primary

Published
2023
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24. supplementary methods from Circulating DNA as a Strong Multimarker Prognostic Tool for Metastatic Colorectal Cancer Patient Management Care

Author

El Messaoudi, Safia, primary, Mouliere, Florent, primary, Du Manoir, Stanislas, primary, Bascoul-Mollevi, Caroline, primary, Gillet, Brigitte, primary, Nouaille, Michelle, primary, Fiess, Catherine, primary, Crapez, Evelyne, primary, Bibeau, Frederic, primary, Theillet, Charles, primary, Mazard, Thibault, primary, Pezet, Denis, primary, Mathonnet, Muriel, primary, Ychou, Marc, primary, and Thierry, Alain R., primary

Published
2023
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25. Supplementary table 1, supplementary table 2 from Circulating DNA as a Strong Multimarker Prognostic Tool for Metastatic Colorectal Cancer Patient Management Care

Author

El Messaoudi, Safia, primary, Mouliere, Florent, primary, Du Manoir, Stanislas, primary, Bascoul-Mollevi, Caroline, primary, Gillet, Brigitte, primary, Nouaille, Michelle, primary, Fiess, Catherine, primary, Crapez, Evelyne, primary, Bibeau, Frederic, primary, Theillet, Charles, primary, Mazard, Thibault, primary, Pezet, Denis, primary, Mathonnet, Muriel, primary, Ychou, Marc, primary, and Thierry, Alain R., primary

Published
2023
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26. Supplemental Material from Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer

Author

Parseghian, Christine M., primary, Parikh, Nila U., primary, Wu, Ji Yuan, primary, Jiang, Zhi-Qin, primary, Henderson, Laura, primary, Tian, Feng, primary, Pastor, Brice, primary, Ychou, Marc, primary, Raghav, Kanwal, primary, Dasari, Arvind, primary, Fogelman, David R., primary, Katsiampoura, Anastasia D., primary, Menter, David G., primary, Wolff, Robert A., primary, Eng, Cathy, primary, Overman, Michael J., primary, Thierry, Alain R., primary, Gallick, Gary E., primary, and Kopetz, Scott, primary

Published
2023
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27. Supplemental Figure 1 from Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer

Author

Parseghian, Christine M., primary, Parikh, Nila U., primary, Wu, Ji Yuan, primary, Jiang, Zhi-Qin, primary, Henderson, Laura, primary, Tian, Feng, primary, Pastor, Brice, primary, Ychou, Marc, primary, Raghav, Kanwal, primary, Dasari, Arvind, primary, Fogelman, David R., primary, Katsiampoura, Anastasia D., primary, Menter, David G., primary, Wolff, Robert A., primary, Eng, Cathy, primary, Overman, Michael J., primary, Thierry, Alain R., primary, Gallick, Gary E., primary, and Kopetz, Scott, primary

Published
2023
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28. Supplemental Table 3 from Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer

Author

Parseghian, Christine M., primary, Parikh, Nila U., primary, Wu, Ji Yuan, primary, Jiang, Zhi-Qin, primary, Henderson, Laura, primary, Tian, Feng, primary, Pastor, Brice, primary, Ychou, Marc, primary, Raghav, Kanwal, primary, Dasari, Arvind, primary, Fogelman, David R., primary, Katsiampoura, Anastasia D., primary, Menter, David G., primary, Wolff, Robert A., primary, Eng, Cathy, primary, Overman, Michael J., primary, Thierry, Alain R., primary, Gallick, Gary E., primary, and Kopetz, Scott, primary

Published
2023
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29. Supplemental Table 1 from Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer

Author

Parseghian, Christine M., primary, Parikh, Nila U., primary, Wu, Ji Yuan, primary, Jiang, Zhi-Qin, primary, Henderson, Laura, primary, Tian, Feng, primary, Pastor, Brice, primary, Ychou, Marc, primary, Raghav, Kanwal, primary, Dasari, Arvind, primary, Fogelman, David R., primary, Katsiampoura, Anastasia D., primary, Menter, David G., primary, Wolff, Robert A., primary, Eng, Cathy, primary, Overman, Michael J., primary, Thierry, Alain R., primary, Gallick, Gary E., primary, and Kopetz, Scott, primary

Published
2023
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30. Supplemental Table 2 from Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer

Author

Parseghian, Christine M., primary, Parikh, Nila U., primary, Wu, Ji Yuan, primary, Jiang, Zhi-Qin, primary, Henderson, Laura, primary, Tian, Feng, primary, Pastor, Brice, primary, Ychou, Marc, primary, Raghav, Kanwal, primary, Dasari, Arvind, primary, Fogelman, David R., primary, Katsiampoura, Anastasia D., primary, Menter, David G., primary, Wolff, Robert A., primary, Eng, Cathy, primary, Overman, Michael J., primary, Thierry, Alain R., primary, Gallick, Gary E., primary, and Kopetz, Scott, primary

Published
2023
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31. supplementary methods from Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer

Author

Prieur, Alexandre, primary, Cappellini, Monica, primary, Habif, Guillaume, primary, Lefranc, Marie-Paule, primary, Mazard, Thibault, primary, Morency, Eric, primary, Pascussi, Jean-Marc, primary, Flacelière, Maud, primary, Cahuzac, Nathalie, primary, Vire, Bérengère, primary, Dubuc, Benjamin, primary, Durochat, Amandine, primary, Liaud, Pierre, primary, Ollier, Jérémy, primary, Pfeiffer, Caroline, primary, Poupeau, Sophie, primary, Saywell, Véronique, primary, Planque, Chris, primary, Assenat, Eric, primary, Bibeau, Frédéric, primary, Bourgaux, Jean-François, primary, Pujol, Pascal, primary, Sézeur, Alain, primary, Ychou, Marc, primary, and Joubert, Dominique, primary

Published
2023
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32. supplementary figures 1 to 13 and supplementary tables 1 to 4 from Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer

Author

Prieur, Alexandre, primary, Cappellini, Monica, primary, Habif, Guillaume, primary, Lefranc, Marie-Paule, primary, Mazard, Thibault, primary, Morency, Eric, primary, Pascussi, Jean-Marc, primary, Flacelière, Maud, primary, Cahuzac, Nathalie, primary, Vire, Bérengère, primary, Dubuc, Benjamin, primary, Durochat, Amandine, primary, Liaud, Pierre, primary, Ollier, Jérémy, primary, Pfeiffer, Caroline, primary, Poupeau, Sophie, primary, Saywell, Véronique, primary, Planque, Chris, primary, Assenat, Eric, primary, Bibeau, Frédéric, primary, Bourgaux, Jean-François, primary, Pujol, Pascal, primary, Sézeur, Alain, primary, Ychou, Marc, primary, and Joubert, Dominique, primary

Published
2023
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33. Supplemental Figure Legends from Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer

Author

Parseghian, Christine M., primary, Parikh, Nila U., primary, Wu, Ji Yuan, primary, Jiang, Zhi-Qin, primary, Henderson, Laura, primary, Tian, Feng, primary, Pastor, Brice, primary, Ychou, Marc, primary, Raghav, Kanwal, primary, Dasari, Arvind, primary, Fogelman, David R., primary, Katsiampoura, Anastasia D., primary, Menter, David G., primary, Wolff, Robert A., primary, Eng, Cathy, primary, Overman, Michael J., primary, Thierry, Alain R., primary, Gallick, Gary E., primary, and Kopetz, Scott, primary

Published
2023
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34. Supplemental Figure 2 from Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer

Author

Parseghian, Christine M., primary, Parikh, Nila U., primary, Wu, Ji Yuan, primary, Jiang, Zhi-Qin, primary, Henderson, Laura, primary, Tian, Feng, primary, Pastor, Brice, primary, Ychou, Marc, primary, Raghav, Kanwal, primary, Dasari, Arvind, primary, Fogelman, David R., primary, Katsiampoura, Anastasia D., primary, Menter, David G., primary, Wolff, Robert A., primary, Eng, Cathy, primary, Overman, Michael J., primary, Thierry, Alain R., primary, Gallick, Gary E., primary, and Kopetz, Scott, primary

Published
2023
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35. Supplementary figure 1, Supplementary figure 2,Supplementary figure 3,Supplementary figure 4 from Circulating DNA as a Strong Multimarker Prognostic Tool for Metastatic Colorectal Cancer Patient Management Care

Author

El Messaoudi, Safia, primary, Mouliere, Florent, primary, Du Manoir, Stanislas, primary, Bascoul-Mollevi, Caroline, primary, Gillet, Brigitte, primary, Nouaille, Michelle, primary, Fiess, Catherine, primary, Crapez, Evelyne, primary, Bibeau, Frederic, primary, Theillet, Charles, primary, Mazard, Thibault, primary, Pezet, Denis, primary, Mathonnet, Muriel, primary, Ychou, Marc, primary, and Thierry, Alain R., primary

Published
2023
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36. Stereotactic MR-Guided Radiotherapy for Liver Metastases: First Results of the Montpellier Prospective Registry Study

Author

Bordeau, Karl, primary, Michalet, Morgan, additional, Keskes, Aïcha, additional, Valdenaire, Simon, additional, Debuire, Pierre, additional, Cantaloube, Marie, additional, Cabaillé, Morgane, additional, Jacot, William, additional, Draghici, Roxana, additional, Demontoy, Sylvain, additional, Quantin, Xavier, additional, Ychou, Marc, additional, Assenat, Eric, additional, Mazard, Thibault, additional, Gauthier, Ludovic, additional, Dupuy, Marie, additional, Guiu, Boris, additional, Bourgier, Céline, additional, Aillères, Norbert, additional, Fenoglietto, Pascal, additional, Azria, David, additional, and Riou, Olivier, additional

Published
2023
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37. Impact of RAS Mutations in Metastatic Colorectal Cancer After Potentially Curative Resection: Does Site of Metastases Matter?

Author

Passot, Guillaume, Kim, Bradford J., Glehen, Olivier, Mehran, Reza J., Kopetz, Scott E., Goere, Diane, Overman, Michael J., Pocard, Marc, Marchal, Frédéric, Conrad, Claudius, Aloia, Thomas A., Vauthey, Jean-Nicolas, Chun, Yun Shin, Abba, Julio, Abboud, Karine, Alyami, Mohammad, Arvieux, Catherine, Asnacios, Amani, Averous, Gerlinde, Bakrin, Naoual, Bardier, Armelle, Rejeb, Houda Ben, Bereder, Jean-Marc, Bernard, Jean-Louis, Bibeau, Frédéric, Bonnefoy, Isabelle, Borg, Christophe, Boschetti, Gilles, Bouarioua, Nadia, Bouche, Olivier, Bouzard, Dominique, Brigand, Cécile, Cacheux, Wulfran, Capitain, Olivier, Carrère, Sébastien, Carretier, Michel, Castel, Benjamin, Chauvenet, Marion, Chevallier, Anne, Coffin, Benoît, Costan, Cristina, Cotte, Eddy, Courvoisier, Thomas, Dahan, Laetitia, Dartigues, Peggy, De Chaisemartin, Cécile, Dechelotte, Pierre, Deguelte-Lardière, Sophie, Delpero, Jean-Robert, Del Grande, Jean, Demarchi, Martin, Desandes, Emmanuel, Desolneux, Grégoire, Dufour, Patrick, Dumont, Frédéric, Durand-Fontanier, Sylvaine, Eveno, Clarisse, Evrard, Serge, Facy, Olivier, Farkhondeh, Fereshteh, Fontaine, Juliette, Gagniere, Johan, Galais, Marie-Pierre, Ghouti, Laurent, Gilly, François-Noël, Goasguen, Nicolas, Gornet, Jean-Marc, Gourdiole, Pierre, Guerin-Meyer, Véronique, Guilloit, Jean-Marc, Guimbaud, Rosine, Guyon, Frédéric, Heyd, Bruno, Heymann, Marie-Françoise, Isaac, Sylvie, Jouet, Pauline, Jourdan-Enfer, Peggy, Jouve, Jean-Louis, Kaci, Rachid, Karoui, Mehdi, Kianmanesh, Reza, Kirzin, Sylvain, Kurtz, Jean-Emmanuel, Labrousse, François, Lebrun-Ly, Valérie, Lefevre, Jérémie, Lelong, Bernard, Lemaistre, Anne-Elisabeth, Leroux-Broussier, Agnès, Levillain, Pierre, Linot, Benjamin, Dico, Réa Lo, Loi, Valéria, Lorimier, Gérard, Mahammat, Abakar, Malka, David, Marchal, Frédéric, Mariani, Antoine, Mariani, Pascale, Mariette, Christophe, Martin, Laurent, Meeus, Pierre, Meffert, Jean-Luc, Messager, Mathieu, Michel, Pierre, Msika, Simon, Muron, Thierry, Noel, Georges, Ortega-Deballon, Pablo, Paquette, Brice, Peoc’h, Michel, Petorin, Caroline, Peyrat, Patrice, Pezet, Denis, Piessen, Guillaume, Pirro, Nicolas, Pocard, Marc, Poizat, Flora, Porcheron, Jack, Poulet, Anaïs, Portales, Fabienne, la Denise, Justine Prost a, Quenet, François, Rat, Patrick, Rebischung, Christine, Regimbeau, Jean-Marc, Rivoirard, Romain, Rohr, Serge, Rougier, Philippe, Rousselot, Pierre, Saban-Roche, Léa, Sabate, Jean-Marc, Sabbagh, Charles, Sabourin, Jean-Christophe, Samalin-Scalzi, Emmanuelle, Seitz, Jean-François, Selves, Janick, Senellart, Helène, Serrano, Martine, Sgabura, Olivia, Sielezneff, Igor, Svrcek, Magali, Taibi, Abdelkader, Taieb, Julien, Thibaudeau, Emilie, Tougeron, David, Tuech, Jean-Jacques, Valmary-Degano, Séverine, Vaudoyer, Delphine, Verriele-Beurrier, Véronique, Villeneuve, Laurent, Volet, Julien, Wernert, Romuald, Ychou, Marc, You, Benoît, Zaanan, Aziz, Zinzindohoue, Franck, and on behalf of the BIG-RENAPE Working Group

Published
2017
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38. Radiological imaging markers predicting clinical outcome in patients with metastatic colorectal carcinoma treated with regorafenib: post hoc analysis of the CORRECT phase III trial (RadioCORRECT study)

Author

Ricotta, Riccardo, Verrioli, Antonella, Ghezzi, Silvia, Porcu, Luca, Grothey, A., Falcone, Alfredo, Van Cutsem, Eric, Argilés, Guillem, Adenis, Antoine, Ychou, Marc, Barone, Carlo, Bouché, Olivier, Peeters, Marc, Humblet, Yves, Mineur, Laurent, Sobrero, Alberto F., Hubbard, Joleen M., Cremolini, Chiara, Prenen, Hans, Tabernero, Josep, Jarraya, Hajer, Mazard, Thibault, Deguelte-Lardiere, Sophie, Papadimitriou, Konstantinos, Van den Eynde, Marc, Pastorino, Alessandro, Redaelli, Daniela, Bencardino, Katia, Funaioli, Chiara, Amatu, Alessio, Carlo-Stella, Giulia, Torri, Valter, Sartore-Bianchi, Andrea, Vanzulli, Angelo, and Siena, Salvatore

Published
2016
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39. Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial

Author

Tabernero, Josep, Lenz, Heinz-Josef, Siena, Salvatore, Sobrero, Alberto, Falcone, Alfredo, Ychou, Marc, Humblet, Yves, Bouché, Olivier, Mineur, Laurent, Barone, Carlo, Adenis, Antoine, Yoshino, Takayuki, Goldberg, Richard M, Sargent, Daniel J, Wagner, Andrea, Laurent, Dirk, Teufel, Michael, Jeffers, Michael, Grothey, Axel, and Van Cutsem, Eric

Published
2015
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40. Stereotactic MR-Guided Adaptive Radiotherapy for Pancreatic Tumors: Updated Results of the Montpellier Prospective Registry Study

Author

Bordeau, Karl, primary, Michalet, Morgan, additional, Keskes, Aïcha, additional, Valdenaire, Simon, additional, Debuire, Pierre, additional, Cantaloube, Marie, additional, Cabaillé, Morgane, additional, Portales, Fabienne, additional, Draghici, Roxana, additional, Ychou, Marc, additional, Assenat, Eric, additional, Mazard, Thibault, additional, Samalin, Emmanuelle, additional, Gauthier, Ludovic, additional, Colombo, Pierre-Emmanuel, additional, Carrere, Sebastien, additional, Souche, François-Régis, additional, Aillères, Norbert, additional, Fenoglietto, Pascal, additional, Azria, David, additional, and Riou, Olivier, additional

Published
2022
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41. Tumor Growth Rate Informs Treatment Efficacy in Metastatic Pancreatic Adenocarcinoma: Application of a Growth and Regression Model to Pivotal Trial and Real-World Data

Author

Yeh, Celine, primary, Zhou, Mengxi, additional, Sigel, Keith, additional, Jameson, Gayle, additional, White, Ruth, additional, Safyan, Rachael, additional, Saenger, Yvonne, additional, Hecht, Elizabeth, additional, Chabot, John, additional, Schreibman, Stephen, additional, Juzyna, Béata, additional, Ychou, Marc, additional, Conroy, Thierry, additional, Fojo, Tito, additional, Manji, Gulam A, additional, Von Hoff, Daniel, additional, and Bates, Susan E, additional

Published
2022
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46. Sequential treatment with gemcitabine/nab-paclitaxel (GA) and FOLFIRINOX (FFX) followed by stereotactic MRI-guided adaptive radiation therapy (SMART) in patients with locally advanced pancreatic cancer (LAPC): GABRINOX-ART phase 2, multicenter trial.

Author

Portales, Fabienne, primary, Ychou, Marc, additional, Samalin, Emmanuelle, additional, Assenat, Eric, additional, Obled, Stephane, additional, Tyran, Marguerite, additional, Mitry, Emmanuel, additional, Rouffiac, Magali, additional, Ghiringhelli, François, additional, Bachet, Jean-Baptiste, additional, Simon, Jean-Marc, additional, De Ridder, Mark, additional, Fiess, Catherine, additional, Moussion, Aurore, additional, Delaine, Stephanie, additional, Grigorescu, Florin, additional, Gourgou, Sophie, additional, and Riou, Olivier, additional

Published
2022
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47. Sequential first-line treatment with gemcitabine plus nab-paclitaxel (GA) followed by FOLFIRINOX (FFX) versus FFX alone in patients with metastatic pancreatic cancer (PC): GABRINOX-2 randomized phase 2 trial.

Author

Portales, Fabienne, primary, Assenat, Eric, additional, Samalin, Emmanuelle, additional, Mazard, Thibault, additional, Adenis, Antoine, additional, Suchet Gallet, Blandine, additional, Fiess, Catherine, additional, Moussion, Aurore, additional, Delaine, Stephanie, additional, Grigorescu, Florin, additional, Gourgou, Sophie, additional, and Ychou, Marc, additional

Published
2022
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48. Regorafenib (REGO) plus FOLFIRINOX as frontline treatment in patients (pts) with RAS-mutated metastatic colorectal cancer (mCRC): A phase I/II, dose-escalation and dose-expansion study.

Author

Adenis, Antoine, primary, Ghiringhelli, François, additional, Gauthier, Ludovic, additional, Mazard, Thibault, additional, Evesque, Ludovic, additional, Etienne, Pierre-Luc, additional, Evrard, Alexandre, additional, Chalbos, Patrick, additional, Bleuse, Jean-Pierre, additional, Tosi, Diego, additional, Gourgou, Sophie, additional, and Ychou, Marc, additional

Published
2022
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49. Highlights of the EORTC St. Gallen International Expert Consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer – Differential treatment strategies for subtypes of early gastroesophageal cancer

Author

Lutz, Manfred P., Zalcberg, John R., Ducreux, Michel, Ajani, Jaffer A., Allum, William, Aust, Daniela, Bang, Yung-Jue, Cascinu, Stefano, Hölscher, Arnulf, Jankowski, Janusz, Jansen, Edwin P.M., Kisslich, Ralf, Lordick, Florian, Mariette, Christophe, Moehler, Markus, Oyama, Tsuneo, Roth, Arnaud, Rueschoff, Josef, Ruhstaller, Thomas, Seruca, Raquel, Stahl, Michael, Sterzing, Florian, van Cutsem, Eric, van der Gaast, Ate, van Lanschot, Jan, Ychou, Marc, and Otto, Florian

Published
2012
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50. Tumor Growth Rate Informs Treatment Efficacy in Metastatic Pancreatic Adenocarcinoma: Application of a Growth and Regression Model to Pivotal Trial and Real-World Data.

Author

Yeh, Celine, Zhou, Mengxi, Sigel, Keith, Jameson, Gayle, White, Ruth, Safyan, Rachael, Saenger, Yvonne, Hecht, Elizabeth, Chabot, John, Schreibman, Stephen, Juzyna, Béata, Ychou, Marc, Conroy, Thierry, Fojo, Tito, Manji, Gulam A, Von Hoff, Daniel, and Bates, Susan E

Subjects
PANCREATIC tumors, ADENOCARCINOMA, CLINICAL trials, LIVER, CANCER chemotherapy, METASTASIS, RETROSPECTIVE studies, DRUG resistance, TREATMENT effectiveness, TUMOR classification, BENCHMARKING (Management), STATISTICAL models, TUMOR antigens, OVERALL survival
Abstract

Background: Methods for screening agents earlier in development and strategies for conducting smaller randomized controlled trials (RCTs) are needed. Methods: We retrospectively applied a tumor growth model to estimate the rates of growth of pancreatic cancer using radiographic tumor measurements or serum CA 19-9 values from 3033 patients with stages III-IV PDAC who were enrolled in 8 clinical trials or were included in 2 large real-world data sets. Results: g correlated inversely with OS and was consistently lower in the experimental arms than in the control arms of RCTs. At the individual patient level, g was significantly faster for lesions metastatic to the liver relative to those localized to the pancreas. Regardless of regimen, g increased toward the end of therapy, often by over 3-fold. Conclusions: Growth rates of PDAC can be determined using radiographic tumor measurement and CA 19-9 values. g is inversely associated with OS and can differentiate therapies within the same trial and across trials. g can also be used to characterize changes in the behavior of an individual's PDAC, such as differences in the growth rate of lesions based on metastatic site, and the emergence of chemoresistance. We provide examples of how g can be used to benchmark phase II and III clinical data to a virtual reference arm to inform go/no go decisions and consider novel trial designs to optimize and accelerate drug development. Novel trial designs, requiring smaller sample sizes, are needed to screen therapies earlier in development and to inform go/no go decisions more accurately. This article describes a kinetic analysis of clinical trial and real-world data from therapies used in the management of metastatic pancreatic ductal adenocarcinoma, using a novel method of analysis indifferent to intervals of assessment to compare data from disparate sources. [ABSTRACT FROM AUTHOR]

Published
2023
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