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135 results on '"Yaziji, Hadi"'

2. Quantitative assessment of PD-L1 as an analyte in immunohistochemistry diagnostic assays using a standardized cell line tissue microarray

Author

Martinez-Morilla, Sandra, McGuire, John, Gaule, Patricia, Moore, Lauren, Acs, Balazs, Cougot, Delphine, Gown, Allen M., Yaziji, Hadi, Wang, Wei-Lien, Cartun, Richard W., Hornick, Jason L., Sholl, Lynette M., Qiu, Jingxin, Mino-Kenudson, Mari, Yi, Eunhee S., Beasley, Mary Beth, Merrick, Daniel T., Ambaye, Abiy B., Zhang, Zhong J., Walker, Jill, and Rimm, David L.

Published
2020
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6. HER-2 testing in breast cancer using parallel tissue-based methods

Author

Yaziji, Hadi, Goldstein, Lynn C., Barry, Todd S., Werling, Robert, Hwang, Harry, Ellis, Georgiana K., Gralow, Julie R., Livingston, Robert B., and Gown, Allen M.

Subjects
Breast cancer -- Diagnosis, Epidermal growth factor -- Testing
Abstract

The HER-2 oncoprotein is overexpressed in 20% to 30% of invasive breast tumors, and its presence confers important prognostic information. Accurate testing for HER-2 in breast cancer can be achieved using immunohistochemistry with complementary fluorescence in situ hybridization (FISH) testing, taking advantage of the strength of each of these technologies.

Published
2004

12. Controversies and guidelines in tissue-based HER-2/neu testing in breast cancer

Author

Yaziji, Hadi and Gown, Allen M.

Subjects
Breast cancer -- Care and treatment, Cancer -- Care and treatment
Abstract

While it is tempting to think of the results of laboratory tests as quantitative, reproducible and accurate, many tests in fact have embedded variables that could lead to inconsistency and [...]

Published
2002

17. Renal Angiomyolipoma: Further Immunophenotypic Characterization of an Expanding Morphologic Spectrum

Author

Stone, Chad H., Lee, Min W., Amin, Mahul B., Yaziji, Hadi, Gown, Allen M., Ro, Jae Y., Tetu, Bernard, Paraf, Francois, and Zarbo, Richard J.

Subjects
Angiolipoma -- Research
Abstract

* Background.--Renal angiomyolipoma is a benign tumor histologically characterized by proliferation of spindle cells, epithelioid cells, and adipocytic cells in concert with many thick-walled blood vessels. To add further diagnostic confusion, an epithelioid cell-predominant variant of renal angiomyolipoma has recently been described. HMB-45 immunoreactivity correlates with ultrastructural striated organelles that closely resemble premelanosomes, although no evidence of melanogenesis has been documented in this tumor. Objective.--To further characterize the immunopheno. typic and ultrastructural profile of renal angiomyolipoma based on phenotypic cell type (epithelioid, spindle, and adipocytic cell). Design.--Formalin.fixed, paraffin-embedded tissues from 27 renal angiomyolipomas and 8 renal cell carcinomas were immunostained with monoclonal antibodies to the melanoma-associated antigens HMB-45, HMB-50, NKI/C3 (CD63), and tyrosinase; the smooth muscle-related antigens calponin and muscle-specific actin (HHF-35); S100; and cytokeratin (CK). All renal angiomyolipomas were also immunostained with a polyclonal antibody to renin. Ultrastructural examination was performed on 9 selected cases. Results.--All renal angiomyolipomas stained positive for HMB-45, HMB-50, NKI/C3, muscle-specific actin (HHF35), and calponin. Overall, HMB-45, HMB-50, and NKI/ C3 preferentially stained the epithelioid cells. Tyrosinase staining was present in 50% of the renal angiomyolipomas with adequate tissue for staining (12 of 24 cases); positive staining and intensity paralleled HMB.45, HMB-50, and NKI/C3. Muscle-specific actin (HHF.35) and calponin preferentially stained the spindle cells. The adipocytic cells stained positive for both melanoma-associated antigens and smooth muscle antigens. Epithelioid cells, spindle cells, and adipocytic cells were CK, S100, and renin negative. Ultrastructural findings paralleled immunohistochemical staining patterns. Premelanosome-like organelles and electron dense granules were more readily detected in the epithelioid cells within the tumor, whereas ultrastructural characteristics of smooth muscle cells were more easily found in the spindle cells. All renal cell carcinomas stained positive for CK, NKI/C3 staining was variable, and all were negative for HMB-45, HMB-50, smooth muscle actin (HHF-35), and calponin. Conclusion.--In renal angiomyolipoma, the epithelioid and spindle cells have preferential staining patterns for melanoma-associated antigens versus smooth muscle antigens, respectively. Positivity in renal angiomyolipoma for HMB-50, NKI/C3, and tyrosinase, in addition to HMB-45, provides evidence for the presence of different melanoma-associated gene products. Immunophenotypic overlap of the 3 histologically distinct renal angiomyolipoma cell populations suggests a common cell line, supporting a unitarian concept for renal angiomyolipoma. Ultrastructural characteristics of the 3 renal angiomyolipoma cell phenotypes parallel the immunophenotype, giving further support to a common cell line. Our study lends further credence to the perivascular epithelioid cell concept as proposed by Bonetti and colleagues. (Arch Pathol Lab Med. 2001 ;125:751-758), Renal angiomyolipoma is an unusual, generally benign tumor that has been associated with tuberous sclerosis and is characterized by a histologic triad of tortuous, thick-walled blood vessels, phenotypic smooth muscle [...]

Published
2001

19. Immunohistochemistry Cocktails Are Here to Stay

Author

Yaziji, Hadi, primary, Eisen, Richard, additional, Wick, Mark, additional, Swanson, Paul, additional, Badve, Sunil, additional, Cartun, Richard, additional, Haas, Thomas, additional, Marolt, Monna, additional, Hicks, David, additional, Martin, Alvin, additional, Barry, Todd, additional, Alsabeh, Randa, additional, Taylor, James, additional, Fulton, Regan, additional, Goldsmith, Jeffrey, additional, Shen, Steven, additional, and Taylor, Clive, additional

Published
2012
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21. Consensus Recommendations on Estrogen Receptor Testing in Breast Cancer By Immunohistochemistry

Author

Yaziji, Hadi, primary, Taylor, Clive R., additional, Goldstein, Neal S., additional, Dabbs, David J., additional, Hammond, Elizabeth H., additional, Hewlett, Bryan, additional, Floyd, Alton D., additional, Barry, Todd S., additional, Martin, Alvn W., additional, Badve, Sunil, additional, Baehner, Frederick, additional, Cartun, Richard W., additional, Eisen, Richard N., additional, Swanson, Paul E., additional, Hewitt, Stephen M., additional, Vyberg, Mogen, additional, and Hicks, David G., additional

Published
2008
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33. Renal Angiomyolipoma

Author

Stone, Chad H., primary, Lee, Min W., additional, Amin, Mahul B., additional, Yaziji, Hadi, additional, Gown, Allen M., additional, Ro, Jae Y., additional, Têtu, Bernard, additional, Paraf, Francois, additional, and Zarbo, Richard J., additional

Published
2001
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