1. Preoperative alkaline phosphatase elevation was associated with poor survival in colorectal cancer patients
- Author
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Pao-Shiu Hsieh, Jinn-Shiun Chen, Chien-YuhYeh, Reiping Tang, Jeng-Fu You, Hsin-Yuan Hung, Yau-Tong You, Jy-Ming Chiang, and Wen-SyTasi
- Subjects
Male ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Time Factors ,Cirrhosis ,Bilirubin ,Colorectal cancer ,Kaplan-Meier Estimate ,Adenocarcinoma ,Gastroenterology ,03 medical and health sciences ,Liver disease ,chemistry.chemical_compound ,0302 clinical medicine ,Carcinoembryonic antigen ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,Aged ,Neoplasm Staging ,Proportional Hazards Models ,Retrospective Studies ,biology ,business.industry ,Cancer ,Middle Aged ,Hepatology ,Alkaline Phosphatase ,medicine.disease ,Up-Regulation ,Treatment Outcome ,030104 developmental biology ,chemistry ,030220 oncology & carcinogenesis ,biology.protein ,Alkaline phosphatase ,Female ,Colorectal Neoplasms ,business - Abstract
Purpose To assess preoperative serum alkaline phosphatase (ALP) levels in colon adenocarcinomapatients with various clinical features and determine its prognostic value. Between 2000 and 2013, 10,800 stage I-IV colon cancer patients who underwent surgery wereretrospectively enrolled. The relationship between ALP level and variables, including age, gender,carcinoembryonic Antigen (CEA) levels, aspartate aminotransferase (AST) level, bilirubin level, tumor size,liver cirrhosis, hepatitis, albumin level, histological type, and TNM-stage, were evaluated. The impact of ALP level elevation on survival was evaluated. Significant elevations in ALP level were found in patients with CEA ≥5 ng/ml (p
- Published
- 2017