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In the title compound, the planes of the benzene and phenyl rings are inclined to the thio­phene ring by 35.2 (4) and 57.7 (3)°, respectively, while the planes of the two aryl rings are almost normal to one another, making a dihedral angle of 86.4 (6)°. In the crystal, mol­ecules are linked by C—H⋯O hydrogen bonds, forming chains propagating along the a-axis direction., In the cyclo­hexene ring of the title compound, C23H20BrNO3S, the –(CH2)4– atoms are positionally disordered [occupancy ratio = 0.753 (6):0.247 (6)]. The ring has a half-chair conformation for both the major and minor components. The dihedral angles between the mean plane of the thio­phene ring and those of the benzene and phenyl rings are 35.2 (4) and 57.7 (3)°, respectively. The planes of the two aryl rings are twisted with respect to each other by 86.4 (6)°. In the mol­ecule, there is an O—H⋯N hydrogen bond forming an S(6) ring motif. In the crystal, mol­ecules are linked via C—H⋯O hydrogen bonds, forming chains parallel to [100].

In three simple clozapinium salts, the unprotonated N atom of the piperazine ring has been variously found to have a pyramidal or planar geometry, with the tricyclic component occupying either the axial or the equatorial position. The supra­molecular assembly is one-dimensional in the 3,5-di­nitro­benzoate salt, two-dimensional in the hydrogen maleate salt and three-dimensional in the 2-hy­droxy­benzoate salt., The structures of three salts derived from clozapine, 8-chloro-11-(4-methyl­piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, are reported, namely, clo­za­pin­ium 3,5-di­nitro­benzoate dimethyl sulfoxide monosolvate, C18H20ClN4 +·C7H3N2O6 −·C2H6OS, (I), where the dimethyl sulfoxide component is disordered over two sets of atomic sites having occupancies 0.627 (2) and 0.373 (2); clo­za­pin­ium hydrogen maleate 0.21-hydrate, C18H20ClN4 +·C4H3O4 −·0.21H2O, (II), and clozapinium 2-hy­droxy­benzoate, C18H20ClN4 +·C7H5O3 −, (III). In all three salts, the protonation site is the methyl­ated N atom of the piperazine ring, and the dimensions and conformations of the fused tricyclic system are very similar. However, differences are apparent in the piperazine component: in both compounds (II) and (III), the unprotonated N atom of this ring has a pyramidal geometry, but in compound (I) this atom has a planar geometry. In compound (III), both N-substituents in this ring occupy equatorial sites, but in compound (II) the fused tricyclic system occupies an axial site of the piperazine ring. The independent components of compound (I) are linked within the selected asymmetric unit by a combination of N—H⋯O and C—H⋯O hydrogen bonds, and these hydrogen-bonded aggregates are linked into chains by an aromatic π–π stacking inter­action. In compound (II), the components are linked into sheets by a combination of O—H⋯O, N—H⋯O and C—H⋯O hydrogen bonds, and in compound (III), a combination of N—H⋯O, C—H⋯O and C—H⋯N hydrogen bonds links the components into a three-dimensional framework structure. Comparisons are made with some similar compounds.

Se han descrito por primera vez métodos espectrofotométricos simples, rápidos y sensitivos para la determinación de fármacos anticancerígenos: el sulfato de vinblastina y el sulfato de vincristina. El primer método está basado en la reacción de copulación de los componentes azoicos del sulfato de vinblastina y el sulfato de vincristina con 4- nitroanilina, que tiene como resultado la formación de productos de color amarillo con una absorbencia máxima de 440 nm y 430 nm respectivamente. Los productos amarillos del VBS y VCS son estables durante una hora a temperatura ambiente y cumplen la ley de Beer, con un intervalo de concentración de 0.5-18 mg en el caso del VBS y un intervalo de 0.5-10 mg ml-1 en el VCS. El segundo método describe la reacción del VBS y VCS con el hierro (III) y 2,4,6- tris (2-piridil)-1,3,5- triazina (TPT) para producir productos de color púrpura que presentan una absorción máxima de 590 nm y permanecen estables durante 48 horas. En este método la ley de Beer se cumple en un intervalo de concentración de 0,2 a 4,0 mg ml-1 en el caso del VBS y de 0,2 a 5,0 mg ml-1 en el VCS. Ambos métodos se han empleado con éxito en la determinación del VBS y VCS en preparaciones farmacéuticas y los resultados obtenidos presentan una comparación favorable respecto al método oficial. Los excipientes comúnmente utilizados como aditivos no interfieren en el análisis. Se han observado algunos datos de precisión y características ópticas., Sensitive, rapid and simple spectrophotometric methods for the determination of anticancer drugs, vinblastine sulphate (VBS) and vincristine sulphate (VCS) have been described for the first time. The first method is based on the azo coupling reaction of VBS and VCS with diazotised 4-nitroaniline (4-NA) resulting in yellow coloured products having absorbance maxima at 440 nm and 430 nm respectively. The yellow products of both VBS and VCS are stable for 1h at room temperature and Beer’s law is obeyed in the concentration range of 0.5-18 mg ml-1 for VBS and 0.5-10 mg ml- 1 for VCS. The second method describes the reaction of VBS and VCS with iron(III) and 2,4,6-tri(2-pyridyl)-1,3,5- triazine (TPT) to produce purple coloured products having absorption maximum at 590 nm and the products are stable for 48h. The Beer’s law for this method is obeyed in the concentration range of 0.2-4.0 mg ml-1 for VBS and 0.2-5.0 mg ml-1 for VCS. Both the methods are successfully employed for the determination of VBS and VCS in pharmaceutical preparations and the results compare favourably with official method. Commonly used excipients as additives do not interfere in the analysis. Some optical characteristics and precision data have been reported.