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1,084 results on '"Yatera, Kazuhiro"'

1. Update of prognosis and characteristics of chronic obstructive pulmonary disease in a real-world setting: a 5-year follow-up analysis of a multi-institutional registry

Author

Takano, Tomotsugu, Tsubouchi, Kazuya, Hamada, Naoki, Ichiki, Katsuyuki, Torii, Ryo, Takata, Shohei, Kawakami, Satoru, Nakagaki, Noriaki, Yoshida, Makoto, Kitasato, Yasuhiko, Tobino, Kazunori, Harada, Eiji, Ishii, Hiroshi, Wataya, Hiroshi, Maeyama, Takashige, Fujita, Masaki, Yatera, Kazuhiro, Okamoto, Masaki, Yabuuchi, Hidetake, Kiyomi, Fumiaki, Tokunaga, Shoji, Nakanishi, Yoichi, and Okamoto, Isamu

Published
2024
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7. Pulmonary function and chest CT abnormalities 3 months after discharge from COVID-19, 2020–2021: A nation-wide multicenter prospective cohort study from the Japanese respiratory society

Author

Kamata, Hirofumi, Takamatsu, Kazufumi, Fukunaga, Koichi, Chubachi, Shotaro, Nakagawara, Kensuke, Namkoong, Ho, Terai, Hideki, Tanaka, Katsushi, Sato, Susumu, Hagiwara, Eri, Takei, Reoto, Kondoh, Yasuhiro, Takazono, Takahiro, Hashimoto, Midori, Tasaka, Sadatomo, Ohrui, Takashi, Tanino, Yoshinori, Mineshita, Masamichi, Komase, Yuko, Miyazaki, Kazuhito, Nishikawa, Masanori, Ando, Akira, Kita, Hideo, Ichihara, Eiki, Ohshimo, Shinichiro, Murata, Yoriyuki, Ishida, Masayuki, Kobayashi, Seiichi, Uchida, Takahiro, Tateno, Hiroki, Ikari, Jun, Terashima, Takeshi, Kozu, Yutaka, Tateishi, Tomoya, Shinkai, Masaharu, Sagara, Hironori, To, Yasuo, Ito, Yoko, Yamamoto, Masaki, Yamamoto, Yoshihiro, Kita, Toshiyuki, Ito, Yutaka, Tomii, Keisuke, Fujita, Yukio, Funaki, Yoshihiro, Yatera, Kazuhiro, Yamasue, Mari, Komiya, Kosaku, Kozawa, Satoko, Manabe, Hideaki, Hozumi, Hironao, Horiguchi, Tomoya, Kitajima, Takamasa, Nakano, Yasushi, Nagaoka, Tetsutaro, Hojo, Masayuki, Ebihara, Akinori, Kobayashi, Masayoshi, Takayama, Koji, Jinta, Torahiko, Sawai, Toyomitsu, Fukuda, Yuichi, Kaneko, Takeshi, Chin, Kazuo, Ogura, Takashi, Mukae, Hiroshi, Ishii, Makoto, and Yokoyama, Akihito

Published
2024
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9. Efficacy and safety of lascufloxacin for nursing- and healthcare-associated pneumonia: A single-arm, open-label clinical trial

Author

Takazono, Takahiro, Hosogaya, Naoki, Fukushima, Koki, Morio, Ryosuke, Irifune, Satoshi, Miyamura, Takuto, Harada, Yosuke, Nagayoshi, Yosuke, Kondo, Akira, Mihara, Tomo, Fukuda, Yuichi, Sasaki, Eisuke, Sawai, Toyomitsu, Imamura, Yoshifumi, Morikawa, Toru, Futsuki, Yoji, Inoue, Yuichi, Fukushima, Kiyoyasu, Suyama, Naofumi, Tanaka, Hikaru, Hanaka, Tetsuya, Shimabukuro, Ikuko, Hata, Ryosuke, Ota, Kenji, Morimoto, Shimpei, Nakada, Nana, Ito, Yuya, Yoshida, Masataka, Takeda, Kazuaki, Ide, Shotaro, Iwanaga, Naoki, Nemoto, Kazuki, Funada, Midori, Izumikawa, Koichi, Yatera, Kazuhiro, Yanagihara, Katsunori, and Mukae, Hiroshi

Published
2024
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10. A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib

Author

Okamoto, Masaki, Fujimoto, Kiminori, Johkoh, Takeshi, Kawaguchi, Atsushi, Mukae, Hiroshi, Sakamoto, Noriho, Ogura, Takashi, Ikeda, Satoshi, Kondoh, Yasuhiro, Yamano, Yasuhiko, Komiya, Kosaku, Umeki, Kenji, Nishikiori, Hirotaka, Tanino, Yoshinori, Tsuda, Toru, Arai, Naoki, Komatsu, Masamichi, Sakamoto, Susumu, Yatera, Kazuhiro, Inoue, Yoshikazu, Miyazaki, Yasunari, Hashimoto, Seishu, Shimizu, Yasuo, Hozumi, Hironao, Ohnishi, Hiroshi, Handa, Tomohiro, Hattori, Noboru, Kishaba, Tomoo, Kato, Motoyasu, Inomata, Minoru, Ishii, Hiroshi, Hamada, Naoki, Konno, Satoshi, Zaizen, Yoshiaki, Azuma, Arata, Suda, Takafumi, Izuhara, Kenji, and Hoshino, Tomoaki

Published
2023
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11. A high α1-antitrypsin/interleukin-10 ratio predicts bacterial pneumonia in adults with community-acquired pneumonia: a prospective cohort study

Author

Miyazaki, Taiga, Fukushima, Kiyoyasu, Hashiguchi, Kohji, Ide, Shotaro, Kobayashi, Tsutomu, Sawai, Toyomitsu, Yatera, Kazuhiro, Kohno, Yoshihisa, Fukuda, Yuichi, Futsuki, Yoji, Matsubara, Yuichi, Koga, Hironobu, Mihara, Tomo, Sasaki, Eisuke, Ashizawa, Nobuyuki, Hirayama, Tatsuro, Takazono, Takahiro, Yamamoto, Kazuko, Imamura, Yoshifumi, Kaku, Norihito, Kosai, Kosuke, Morinaga, Yoshitomo, Yanagihara, Katsunori, and Mukae, Hiroshi

Published
2023
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14. Refractory phenotype of Aspergillus-sensitized asthma with bronchiectasis and allergic bronchopulmonary aspergillosis

Author

Ikeda, Miho, Okamura, Kayoko, Ohnishi, Hisashi, Terada-Hirashima, Junko, Hojo, Masayuki, Isogai, Sumito, Imaizumi, Kazuyoshi, Horiguchi, Takahiro, Hirano, Ryosuke, Fujita, Masaki, Toyoshima, Mikio, Fujisawa, Tomoyuki, Suda, Takafumi, Takaki, Yoichi, Higaki, Naoko, Miyamoto, Shintaro, Nakashima, Taku, Iwamoto, Hiroshi, Hattori, Noboru, Mikami, Koji, Minami, Toshiyuki, Takahashi, Ryo, Kijima, Takashi, Tobino, Kazunori, Hoshino, Makoto, Imokawa, Shiro, Tsuji, Taisuke, Hiraoka, Noriya, Ikeue, Tatsuyoshi, Sugita, Takakazu, Kunichika, Naomi, Tomari, Shinya, Okochi, Yasumi, Mato, Naoko, Hagiwara, Koichi, Dobashi, Kunio, Taooka, Yasuyuki, Harada, Norihiro, Machida, Kentaro, Inoue, Hiromasa, Tanosaki, Takae, Masaki, Katsunori, Fukunaga, Koichi, Sano, Akiko, Iwanaga, Takashi, Higashimoto, Yuji, Tohda, Yuji, Matsumoto, Masataka, Takatsuki, Kiyonobu, Nagata, Kazuma, Tachikawa, Ryo, Tomii, Keisuke, Kaneko, Masahiro, Tomioka, Hiromi, Nagano, Tatsuya, Nishimura, Yoshihiro, Yamane, Mayuka, Yokoyama, Akihito, Yoshida, Chieko, Sakagami, Takuro, Seto, Yurie, Kaneko, Yoshiko, Takayama, Koichi, Hayashi, Yusuke, Terada, Satoru, Nishi, Kenta, Sunadome, Hironobu, Nagasaki, Tadao, Oguma, Tsuyoshi, Tanabe, Naoya, Hirai, Toyohiro, Nomura, Natsuko, Matsumoto, Hisako, Tajiri, Tomoko, Niimi, Akio, Nakamura, Saya, Wakahara, Keiko, Hashimoto, Naozumi, Ito, Takefumi, Nakano, Takako F., Yamashita, Takafumi, Takata, Shohei, Seri, Yoshihiro, Mizumori, Yasuyuki, Tsukamoto, Hiroaki, Kagami, Ryogo, Nakahara, Yasuharu, Kawamura, Tetsuji, Ishii, Yukio, Kita, Toshiyuki, Hidaka, Kouko, Kadowaki, Toru, Minakuchi, Masayoshi, Tsuboi, Tomomasa, Tamaki, Shinji, Matsuki, Takanori, Kida, Hiroshi, Miki, Mari, Tomita, Katsuyuki, Abe, Takashi, Shindoh, Joe, Taniguchi, Akihiko, Miyahara, Nobuaki, Azuma, Masato, Kataoka, Mikio, Matsuno, Osamu, Ogawa, Haruhiko, Matsumoto, Takeshi, Aihara, Kensaku, Nakagome, Kazuyuki, Nagata, Makoto, Miyajima, Satsuki, Hashimoto, Kentaro, Shiota, Tetsuhiro, Yamaguchi, Masafumi, Nakano, Yasutaka, Otsuka, Kojiro, Yasuo, Masanori, Hanaoka, Masayuki, Yamada, Takashi, Shirai, Toshihiro, Iwasaki, Yoshinobu, Mineshita, Masamichi, Tsuburai, Takahiro, Komase, Yuko, Koh, Hidefumi, Hasegawa, Koichi, Kita, Hideo, Nagase, Hiroyuki, Murakami, Koji, Sugiura, Hisatoshi, Ichinose, Masakazu, Kutsuzawa, Tomoko, Tanaka, Jun, Asano, Koichiro, Kono, Yuta, Abe, Shinji, Nakamura, Morio, Orimo, Mami, Tagaya, Etsuko, Kondo, Mitsuko, Matsuda, Toshiaki, Kimura, Tomoki, Harada, Tomoya, Yamasaki, Akira, Taniguchi, Hirokazu, Iijima, Hiroaki, Kawabata, Hiroki, Yatera, Kazuhiro, Masuko, Hironori, Morishima, Yuko, Hizawa, Nobuyuki, Nakanishi, Masanori, Yamamoto, Nobuyuki, Inoue, Sumito, Hamada, Kazuki, Yamaji, Yoshikazu, Hirano, Tsunahiko, Matsunaga, Kazuto, and Sato, Yoko

Published
2024
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16. Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2019–2020: General view of the pathogens' antibacterial susceptibility

Author

Tokimatsu, Issei, Matsumoto, Tetsuya, Tsukada, Hiroki, Fujikura, Yuji, Miki, Makoto, Morinaga, Yoshitomo, Sato, Junko, Wakamura, Tomotaro, Kiyota, Hiroshi, Tateda, Kazuhiro, Yanagisawa, Hideji, Sasaki, Takaaki, Ikeda, Hideki, Horikawa, Hiroshi, Takahashi, Hiroshi, Seki, Masafumi, Mori, Yoshiaki, Takeda, Hiroaki, Kurai, Daisuke, Hasegawa, Naoki, Uwamino, Yoshifumi, Kudo, Makoto, Yamamoto, Masaki, Nagano, Yuko, Nomura, Sakika, Tetsuka, Takafumi, Hosokai, Miyuki, Aoki, Nobuki, Yamamoto, Yoshihiro, Iinuma, Yoshitsugu, Mikamo, Hiroshige, Suematsu, Hiroyuki, Maruyama, Takaya, Kawabata, Atsushi, Sugaki, Yoshiko, Nakamura, Atsushi, Fujikawa, Yasunori, Fukumori, Tatsuya, Ukimura, Akira, Kakeya, Hiroshi, Niki, Makoto, Yoshida, Koichiro, Kobashi, Yoshihiro, Tokuyasu, Hirokazu, Yatera, Kazuhiro, Ikegami, Hiroaki, Fujita, Masaki, Matsumoto, Takemasa, Yanagihara, Katsunori, Matsuda, Junichi, Hiramatsu, Kazufumi, and Shinzato, Takashi

Published
2023
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17. Multicenter, single-blind, randomized controlled study of the efficacy and safety of favipiravir and nafamostat mesilate in patients with COVID-19 pneumonia

Author

Ikeda, Mahoko, Okugawa, Shu, Kashiwabara, Kosuke, Moritoyo, Takashi, Kanno, Yoshiaki, Jubishi, Daisuke, Hashimoto, Hideki, Okamoto, Koh, Tsushima, Kenji, Uchida, Yasuki, Mitsumura, Takahiro, Igari, Hidetoshi, Tsutsumi, Takeya, Araoka, Hideki, Yatera, Kazuhiro, Yamamoto, Yoshihiro, Nakamura, Yuki, Otani, Amato, Yamashita, Marie, Wakimoto, Yuji, Shinohara, Takayuki, Adachi-Katayama, Maho, Oyabu, Tatsunori, Kanematsu, Aoi, Harada, Sohei, Takeshita, Yuichiro, Nakano, Yasutaka, Miyazaki, Yasunari, Sakao, Seiichiro, Saito, Makoto, Ogura, Sho, Yamasaki, Kei, Kawasuji, Hitoshi, Hataji, Osamu, Inoue, Jun-Ichiro, Seto, Yasuyuki, and Moriya, Kyoji

Published
2023
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25. Role of Nitric Oxide Synthases in Respiratory Health and Disease: Insights from Triple Nitric Oxide Synthases Knockout Mice.

Author

Ogoshi, Takaaki, Yatera, Kazuhiro, Mukae, Hiroshi, and Tsutsui, Masato

Subjects
*PULMONARY fibrosis, *PULMONARY emphysema, *BONE marrow transplantation, *SODIUM nitrate, *PULMONARY hypertension
Abstract

The system of nitric oxide synthases (NOSs) is comprised of three isoforms: nNOS, iNOS, and eNOS. The roles of NOSs in respiratory diseases in vivo have been studied by using inhibitors of NOSs and NOS-knockout mice. Their exact roles remain uncertain, however, because of the non-specificity of inhibitors of NOSs and compensatory up-regulation of other NOSs in NOS-KO mice. We addressed this point in our triple-n/i/eNOSs-KO mice. Triple-n/i/eNOSs-KO mice spontaneously developed pulmonary emphysema and displayed exacerbation of bleomycin-induced pulmonary fibrosis as compared with wild-type (WT) mice. Triple-n/i/eNOSs-KO mice exhibited worsening of hypoxic pulmonary hypertension (PH), which was reversed by treatment with sodium nitrate, and WT mice that underwent triple-n/i/eNOSs-KO bone marrow transplantation (BMT) also showed aggravation of hypoxic PH compared with those that underwent WT BMT. Conversely, ovalbumin-evoked asthma was milder in triple-n/i/eNOSs-KO than WT mice. These results suggest that the roles of NOSs are different in different pathologic states, even in the same respiratory diseases, indicating the diversity of the roles of NOSs. In this review, we describe these previous studies and discuss the roles of NOSs in respiratory health and disease. We also explain the current state of development of inorganic nitrate as a new drug for respiratory diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Clarithromycin Modulates Neutrophilic Inflammation Induced by Prevotella intermedia in Human Airway Epithelial Cells.

Author

Iwanaga, Naoki, Ota, Ayaka, Ashizawa, Hiroki, Ito, Yuya, Hirayama, Tatsuro, Yoshida, Masataka, Takeda, Kazuaki, Ide, Shotaro, Tashiro, Masato, Hosogaya, Naoki, Sakamoto, Noriho, Takazono, Takahiro, Kosai, Kosuke, Naito, Mariko, Tanaka, Yoshimasa, Yatera, Kazuhiro, Izumikawa, Koichi, Yanagihara, Katsunori, and Mukae, Hiroshi

Subjects
EXTRACELLULAR signal-regulated kinases, MITOGEN-activated protein kinases, PROTEIN kinase inhibitors, GENETIC transcription, EPITHELIAL cells
Abstract

Objectives: In the present study, we aimed to clarify the mechanisms by which periodontal pathogens, particularly Prevotella intermedia, induce severe neutrophilic inflammation. In addition, we aimed to test the efficacy of macrolides, which has not been resolved in the neutrophilic inflammation induced by P. intermedia. Methods: NCl-H292 human airway epithelial cells were pre-incubated with clarithromycin for 2 h before incubation with P. intermedia supernatants. Then, C-X-C motif chemokine ligand 8 (CXCL8) transcription and interleukin (IL)-8 production were measured. To elucidate the signaling pathway, mitogen-activated protein kinase inhibitors were added to the cell culture, and the cells were subjected to Western blotting. Results:P. intermedia supernatants promoted CXCL8 transcription and IL-8 production, and the reactions were significantly suppressed by clarithromycin pretreatment. Only trametinib, the selective mitogen-activated extracellular signal-regulated kinase inhibitor, downregulated CXCL8 transcription and IL-8 production. Furthermore, Western blotting revealed that stimulation with P. intermedia supernatants specifically induces extracellular signal-regulated kinases (ERK) 1/2 phosphorylation, which is suppressed by clarithromycin pretreatment. Notably, the interference analysis revealed that ERK3 might be dispensable for IL-8 production under the stimulation of P. intermedia supernatants. Conclusions: Our results provide new insight into the mechanism underlying P. intermedia-induced production of IL-8 from human airway epithelial cells. Furthermore, macrolides might have therapeutic potential in regulating periodontal pathogen-induced neutrophilic inflammation in the lungs. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Prognosis and management of chronic obstructive pulmonary disease in a real-world setting: A 5-year follow-up analysis of a multi-institutional registry

Author

Takano, Tomotsugu, primary, Tsubouchi, Kazuya, additional, Hamada, Naoki, additional, Ichiki, Katsuyuki, additional, Torii, Ryo, additional, Takata, Shohei, additional, Kawakami, Satoru, additional, Nakagaki, Noriaki, additional, Yoshida, Makoto, additional, Kitasato, Yasuhiko, additional, Tobino, Kazunori, additional, Harada, Eiji, additional, Ishii, Hiroshi, additional, Wataya, Hiroshi, additional, Maeyama, Takashige, additional, Fujita, Masaki, additional, Yatera, Kazuhiro, additional, Okamoto, Masaki, additional, Yabuuchi, Hidetake, additional, Kiyomi, Fumiaki, additional, Tokunaga, Shoji, additional, Nakanishi, Yoichi, additional, and Okamoto, Isamu, additional

Published
2024
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30. HLA-B54 is an independent risk factor for pneumonia in Japanese patients with interstitial lung disease: A multicenter retrospective cohort study

Author

Sakamoto, Noriho, Ishimoto, Hiroshi, Tahara, Masahiro, Kido, Takashi, Hara, Atsuko, Miyamura, Takuto, Okuno, Daisuke, Tokito, Takatomo, Yoshioka, Sumako, Morimoto, Shimpei, Takazono, Takahiro, Yamamoto, Kazuko, Yamaguchi, Hiroyuki, Obase, Yasushi, Ishimatsu, Yuji, Yatera, Kazuhiro, and Mukae, Hiroshi

Published
2021
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33. Safety and tolerability of combination therapy with pirfenidone and nintedanib for idiopathic pulmonary fibrosis: A multicenter retrospective observational study in Japan

Author

Hisata, Shu, Bando, Masashi, Homma, Sakae, Kataoka, Kensuke, Ogura, Takashi, Izumi, Shinyu, Sakamoto, Susumu, Watanabe, Kizuku, Saito, Yoshinobu, Shimizu, Yasuo, Kato, Motoyasu, Nishioka, Yasuhiko, Hara, Hiromichi, Waseda, Yuko, Tanino, Yoshinori, Yatera, Kazuhiro, Hashimoto, Seishu, Mukae, Hiroshi, and Inase, Naohiko

Published
2021
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34. Evaluation of four commercial severe acute respiratory coronavirus 2 antibody tests

Author

Ashizawa, Nobuyuki, Takazono, Takahiro, Ohyama, Kaname, Nagasaki, Yoji, Okamoto, Masaki, Hirayama, Tatsuro, Takahashi, Kensuke, Yamanashi, Hirotomo, Tashiro, Masato, Hosogaya, Naoki, Tanaka, Takeshi, Yamamoto, Kazuko, Fukuda, Yuichi, Imamura, Yoshifumi, Kawanami, Toshinori, Miyazaki, Taiga, Sawai, Toyomitsu, Fukushima, Kiyoyasu, Yatera, Kazuhiro, Yanagihara, Katsunori, Izumikawa, Koichi, and Mukae, Hiroshi

Published
2021
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35. The Japanese respiratory society guidelines for the management of cough and sputum (digest edition)

Author

Mukae, Hiroshi, Kaneko, Takeshi, Obase, Yasushi, Shinkai, Masaharu, Katsunuma, Toshio, Takeyama, Kiyoshi, Terada, Jiro, Niimi, Akio, Matsuse, Hiroto, Yatera, Kazuhiro, Yamamoto, Yoshihiro, Azuma, Arata, Arakawa, Hirokazu, Iwanaga, Takashi, Ogawa, Haruhiko, Kurahashi, Kiyoyasu, Gon, Yasuhiro, Sakamoto, Hirokazu, Shibata, Yoko, Tamada, Tsutomu, Nishioka, Yasuhiko, Haranaga, Shusaku, Fujieda, Shigeharu, Miyashita, Naoyuki, Mochizuki, Hiroyuki, Yokoyama, Akihito, Yoshihara, Shigemi, and Tamaoki, Jun

Published
2021
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37. Contemporary Concise Review 2023: Environmental and occupational lung diseases.

Author

Yatera, Kazuhiro and Nishida, Chinatsu

Subjects
*LUNG diseases, *OCCUPATIONAL diseases, *PLEURA diseases, *HYPERSENSITIVITY pneumonitis, *PULMONARY fibrosis, *PLEURA cancer, *CHRONIC obstructive pulmonary disease
Abstract

SUMMARY OF KEY POINTS: Air pollutants have various effects on human health in environmental and occupational settings.Air pollutants can be a risk factor for incidence, exacerbation/aggravation and death due to various lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), hypersensitivity pneumonitis or pneumonia (HP), pulmonary fibrosis such as pneumoconiosis and malignant respiratory diseases such as lung cancer and malignant pleural mesothelioma.Environmental and occupational respiratory diseases are crucial clinical and social issues worldwide, although the burden of respiratory disease due to environmental and occupational causes varies depending on country/region, demographic variables, geographical location, industrial structure and socioeconomic situation.The correct recognition of environmental and occupational lung diseases and taking appropriate measures are essential to their effective prevention. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Allergic bronchopulmonary aspergillosis with metachronous isolation of three distinct Aspergillus species.

Author

Sasahara, Yosuke, Akata, Kentaro, Yamasaki, Kei, Orihashi, Takeshi, and Yatera, Kazuhiro

Subjects
ASPERGILLUS, ASPERGILLUS fumigatus, JAPANESE people, SPECIES, PULMONARY aspergillosis, ASPERGILLUS flavus, ORAL drug administration
Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is an inflammatory disease induced by exaggerated immune responses to Aspergillus species. Although ABPA has a high recurrence (48%), its instances with sequential isolation of distinct Aspergillus species are sporadic. Only one case report has documented the metachronous isolation of Aspergillus fumigatus and Aspergillus flavus. However, no reported cases of metachronous isolation involving three distinct Aspergillus species exist. Herein, we report a novel case of a 47‐year‐old Japanese man with sequential metachronous isolation of A. flavus, A. terreus, and A. fumigatus. Initially presenting with symptoms of productive cough and pulmonary infiltration, the patient experienced two relapses following treatment with oral prednisolone. Adjustments in therapy, including voriconazole and a tailored corticosteroid regimen, resulted in significant improvement without relapse for over 6 months. This case report highlights the challenges and successful management of ABPA involving multiple Aspergillus species. [ABSTRACT FROM AUTHOR]

Published
2024
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39. A combined small cell lung carcinoma patient with only small cell carcinoma components in mediastinal lymph node metastasis and chondrosarcoma‐like components in liver metastasis.

Author

Kawaguchi, Takako, Yamasaki, Kei, Shigemi, Saki, Dosaka, Hiroki, Hirosawa, Riho, Nagasawa, Taiga, Fujimoto, Satoshi, Shimajiri, Shohei, and Yatera, Kazuhiro

Subjects
SMALL cell carcinoma, LYMPHATIC metastasis, LIVER metastasis, CHONDROSARCOMA, CELL anatomy, JAPANESE people
Abstract

A 69‐year‐old ex‐smoker Japanese man presented with a left mediastinal lymph node and left upper lobe tumour. Bronchoscopic biopsy specimens from the enlarged left mediastinal lymph node and left upper lobe tumour revealed small cell lung carcinoma (SCLC). He was treated with first‐line chemotherapy with carboplatin, etoposide, and atezolizumab for four courses and subsequent atezolizumab maintenance therapy. However, his left upper lobe lung tumour only increased in size, and left upper lobectomy revealed combined SCLC (adenocarcinoma and chondrosarcoma‐like features). Four months after lobectomy, liver metastasis of chondrosarcoma‐like features (similar to pathological findings of the left upper lobe tumour) were observed. Combined SCLC, including sarcomatous components, is rare and poorly responds to chemotherapy. The metastases of combined SCLC in this patient were of only one type of histological component, making diagnosis and treatment difficult. If treatment for SCLC responds inadequately, considering combined SCLC and actively re‐examining histological diagnosis is necessary. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Clinical features relating to pneumococcal colony phase variation in hospitalized adults with pneumonia

Author

Ideguchi, Shuhei, primary, Yamamoto, Kazuko, additional, Takazono, Takahiro, additional, Fukuda, Yuichi, additional, Tashiro, Takahiro, additional, Shizukuishi, Sayaka, additional, Chang, Bin, additional, Ogawa, Michinaga, additional, Izumikawa, Koichi, additional, Yanagihara, Katsunori, additional, Yatera, Kazuhiro, additional, and Mukae, Hiroshi, additional

Published
2024
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46. Combined detection of lymphocyte clonality and MALT1 translocations in bronchoalveolar lavage fluid for diagnosing pulmonary lymphomas

Author

Kido, Takashi, Ishimoto, Hiroshi, Ishii, Hiroshi, Hara, Kanako, Ozasa, Mutsumi, Kawabata, Hiroki, Kawanami, Toshinori, Suzuki, Yu, Yoshikawa, Hiroki, Hara, Atsuko, Sakamoto, Noriho, Matsumoto, Nobuhiro, Yoshii, Chiharu, Fukuoka, Junya, Fujita, Masaki, Nakazato, Masamitsu, Kadota, Junichi, Mukae, Hiroshi, and Yatera, Kazuhiro

Published
2021
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47. Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for clinical microbiology in 2014: General view of the pathogens' antibacterial susceptibility

Author

Yanagihara, Katsunori, Matsumoto, Tetsuya, Aoki, Nobuki, Sato, Junko, Wakamura, Tomotaro, Kiyota, Hiroshi, Tateda, Kazuhiro, Hanaki, Hideaki, Ohsaki, Yoshinobu, Fujiuchi, Satoru, Takahashi, Manabu, Akiba, Yuji, Masunaga, Shingo, Takeuchi, Kenichi, Takeda, Hiroaki, Miki, Makoto, Kumagai, Toshio, Takahashi, Hiroshi, Utagawa, Mutsuko, Nishiya, Hajime, Kawakami, Sayoko, Ishigaki, Shinobu, Kobayasi, Nobuyuki, Takasaki, Jin, Mezaki, Kazuhisa, Iwata, Satoshi, Katouno, Yasuhiro, Inose, Rika, Niki, Yoshihito, Kawana, Akihiko, Fujikura, Yuji, Kudo, Makoto, Hirano, Tomo, Yamamoto, Masaki, Miyazawa, Naoki, Tsukada, Hiroki, Aso, Sakura, Yamamoto, Yoshihiro, Iinuma, Yoshitsugu, Mikamo, Hiroshige, Yamagishi, Yuka, Nakamura, Atsushi, Ohashi, Minoru, Kawabata, Atsushi, Sugaki, Yoshiko, Seki, Masafumi, Hamaguchi, Shigeto, Toyokawa, Masahiro, Kakeya, Hiroshi, Fujikawa, Yasunori, Mitsuno, Noriko, Ukimura, Akira, Miyara, Takayuki, Hayasi, Michio, Mikasa, Keiichi, Kasahara, Kei, Koizumi, Akira, Korohasi, Nobuyoshi, Matumoto, Takashi, Yosimura, Yutaka, Katanami, Yuichi, Takesue, Yoshio, Wada, Yasunao, Sugimoto, Keisuke, Yamamoto, Tsuyoshi, Kuwabara, Masao, Doi, Masao, Simizu, Satomi, Tokuyasu, Hirokazu, Hino, Satoshi, Negayama, Kiyoshi, Mukae, Hiroshi, Kawanami, Toshinori, Yatera, Kazuhiro, Fujita, Masaki, Kadota, Junichi, Hiramatsu, Kazufumi, Aoki, Yosuke, Magarifuchi, Hiroki, Oho, Megumi, Morinaga, Yoshitomo, Suga, Moritaka, Muranaka, Hiroyuki, Fujita, Jiro, Higa, Futoshi, and Tateyama, Masao

Published
2019
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50. The Effects of Endoplasmic Reticulum Stress via Intratracheal Instillation of Water-Soluble Acrylic Acid Polymer on the Lungs of Rats.

Author

Morimoto, Toshiki, Izumi, Hiroto, Tomonaga, Taisuke, Nishida, Chinatsu, Kawai, Naoki, Higashi, Yasuyuki, Wang, Ke-Yong, Ono, Ryohei, Sumiya, Kazuki, Sakurai, Kazuo, Moriyama, Akihiro, Takeshita, Jun-ichi, Yamasaki, Kei, Yatera, Kazuhiro, and Morimoto, Yasuo

Subjects
ENDOPLASMIC reticulum, ACRYLIC acid, LUNGS, COSMETICS manufacturing, RATS, WATER-soluble polymers, POLYACRYLIC acid
Abstract

Polyacrylic acid (PAA), an organic chemical, has been used as an intermediate in the manufacture of pharmaceuticals and cosmetics. It has been suggested recently that PAA has a high pulmonary inflammatory and fibrotic potential. Although endoplasmic reticulum stress is induced by various external and intracellular stimuli, there have been no reports examining the relationship between PAA-induced lung injury and endoplasmic reticulum stress. F344 rats were intratracheally instilled with dispersed PAA (molecular weight: 269,000) at low (0.5 mg/mL) and high (2.5 mg/mL) doses, and they were sacrificed at 3 days, 1 week, 1 month, 3 months and 6 months after exposure. PAA caused extensive inflammation and fibrotic changes in the lungs' histopathology over a month following instillation. Compared to the control group, the mRNA levels of endoplasmic reticulum stress markers Bip and Chop in BALF were significantly increased in the exposure group. In fluorescent immunostaining, both Bip and Chop exhibited co-localization with macrophages. Intratracheal instillation of PAA induced neutrophil inflammation and fibrosis in the rat lung, suggesting that PAA with molecular weight 269,000 may lead to pulmonary disorder. Furthermore, the presence of endoplasmic reticulum stress in macrophages was suggested to be involved in PAA-induced lung injury. [ABSTRACT FROM AUTHOR]

Published
2024
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