Search

Your search keyword '"Yasui, Hideki"' showing total 482 results
Start Over Author "Yasui, Hideki"
482 results on '"Yasui, Hideki"'

1. Risk factors for relapse of immune-related pneumonitis after 6-week oral prednisolone therapy: a follow-up analysis of a phase II study

Author

Karayama, Masato, Inui, Naoki, Inoue, Yusuke, Yasui, Hideki, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Fujisawa, Tomoyuki, Enomoto, Noriyuki, Asada, Kazuhiro, Nishimoto, Koji, Fujii, Masato, Matsui, Takashi, Matsuura, Shun, Hashimoto, Dai, Toyoshima, Mikio, Ikeda, Masaki, Matsuda, Hiroyuki, Inami, Nao, Kaida, Yusuke, Funayama, Satoshi, Ichikawa, Shintaro, Goshima, Satoshi, and Suda, Takafumi

Published
2024
Full Text
View/download PDF

2. CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study

Author

Enomoto, Noriyuki, Nakai, Shogo, Yazawa, Shusuke, Mochizuka, Yasutaka, Fukada, Atsuki, Tanaka, Yuko, Naoi, Hyogo, Inoue, Yusuke, Yasui, Hideki, Karayama, Masato, Suzuki, Yuzo, Hozumi, Hironao, Furuhashi, Kazuki, Toyoshima, Mikio, Kono, Masato, Imokawa, Shiro, Fujii, Masato, Akamatsu, Taisuke, Koshimizu, Naoki, Yokomura, Koshi, Matsuda, Hiroyuki, Kaida, Yusuke, Nakamura, Yutaro, Shirai, Masahiro, Mori, Kazutaka, Masuda, Masafumi, Fujisawa, Tomoyuki, Inui, Naoki, Sugiura, Hiroaki, Sumikawa, Hiromitsu, Kitani, Masashi, Tabata, Kazuhiro, Ogawa, Noriyoshi, and Suda, Takafumi

Published
2024
Full Text
View/download PDF

5. Pan-cancer assessment of antineoplastic therapy-induced interstitial lung disease in patients receiving subsequent therapy immediately following immune checkpoint blockade therapy

Author

Kitahara, Yoshihiro, Inoue, Yusuke, Yasui, Hideki, Karayama, Masato, Suzuki, Yuzo, Hozumi, Hironao, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, Funai, Kazuhito, Honda, Tetsuya, Misawa, Kiyoshi, Miyake, Hideaki, Takeuchi, Hiroya, Inui, Naoki, and Suda, Takafumi

Published
2024
Full Text
View/download PDF

7. Cytokine profiling identifies circulating IL-6 and IL-15 as prognostic stratifiers in patients with non-small cell lung cancer receiving anti-PD-1/PD-L1 blockade therapy

Author

Inoue, Yusuke, Inui, Naoki, Karayama, Masato, Asada, Kazuhiro, Fujii, Masato, Matsuura, Shun, Uto, Tomohiro, Hashimoto, Dai, Matsui, Takashi, Ikeda, Masaki, Yasui, Hideki, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, and Suda, Takafumi

Published
2023
Full Text
View/download PDF

8. Serum immune modulators associated with immune-related toxicities and efficacy of atezolizumab in patients with non-small cell lung cancer

Author

Inoue, Yusuke, Inui, Naoki, Karayama, Masato, Asada, Kazuhiro, Matsuura, Shun, Ikeda, Masaki, Uto, Tomohiro, Fujii, Masato, Hashimoto, Dai, Matsui, Takashi, Matsuda, Hiroyuki, Inami, Nao, Toyoshima, Mikio, Kaida, Yusuke, Yasui, Hideki, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, and Suda, Takafumi

Published
2023
Full Text
View/download PDF

9. Radiological and histopathological features and treatment response by subtypes of interstitial pneumonia with autoimmune features: A prospective, multicentre cohort study

Author

Enomoto, Noriyuki, Yazawa, Shusuke, Mochizuka, Yasutaka, Fukada, Atsuki, Tanaka, Yuko, Naoi, Hyogo, Aono, Yuya, Inoue, Yusuke, Yasui, Hideki, Karayama, Masato, Suzuki, Yuzo, Hozumi, Hironao, Furuhashi, Kazuki, Toyoshima, Mikio, Kono, Masato, Imokawa, Shiro, Sano, Takehisa, Akamatsu, Taisuke, Koshimizu, Naoki, Yokomura, Koshi, Matsuda, Hiroyuki, Kaida, Yusuke, Shirai, Masahiro, Mori, Kazutaka, Masuda, Masafumi, Fujisawa, Tomoyuki, Inui, Naoki, Nakamura, Yutaro, Sugiura, Hiroaki, Sumikawa, Hiromitsu, Kitani, Masashi, Tabata, Kazuhiro, Ogawa, Noriyoshi, and Suda, Takafumi

Published
2024
Full Text
View/download PDF

12. Olanzapine Plus Triple Antiemetic Therapy for the Prevention of Carboplatin-Induced Nausea and Vomiting: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial

Author

Inui, Naoki, primary, Suzuki, Takahito, additional, Tanaka, Kazuki, additional, Karayama, Masato, additional, Inoue, Yusuke, additional, Mori, Kazutaka, additional, Yasui, Hideki, additional, Hozumi, Hironao, additional, Suzuki, Yuzo, additional, Furuhashi, Kazuki, additional, Fujisawa, Tomoyuki, additional, Matsuura, Shun, additional, Nishimoto, Koji, additional, Matsui, Takashi, additional, Asada, Kazuhiro, additional, Hashimoto, Dai, additional, Fujii, Masato, additional, Niwa, Mitsuru, additional, Uehara, Masahiro, additional, Matsuda, Hiroyuki, additional, Koda, Keigo, additional, Ikeda, Masaki, additional, Inami, Nao, additional, Tamiya, Yutaro, additional, Kato, Masato, additional, Nakano, Hideki, additional, Mino, Yasuaki, additional, Enomoto, Noriyuki, additional, and Suda, Takafumi, additional

Published
2024
Full Text
View/download PDF

14. Obesity impairs ciliary function and mucociliary clearance in the murine airway epithelium.

Author

Tanaka, Yuko, Fujisawa, Tomoyuki, Yazawa, Shusuke, Ohta, Isao, Takaku, Yasuharu, Ito, Masahiko, Inoue, Yusuke, Yasui, Hideki, Hozumi, Hironao, Karayama, Masato, Suzuki, Yuzo, Furuhashi, Kazuki, Enomoto, Noriyuki, Setou, Mitsutoshi, Inui, Naoki, Suzuki, Tetsuro, and Suda, Takafumi

Subjects
MUCOCILIARY system, REGULATOR genes, ADENOSINE triphosphate, TISSUE culture, INFLUENZA A virus, VIRUS diseases
Abstract

Obesity is a risk factor for increased morbidity and mortality in viral respiratory infection. Mucociliary clearance (MCC) in the airway is the primary host defense against viral infections. However, the impact of obesity on MCC is unclear, prompting this study. Using murine tracheal tissue culture and in vitro influenza A virus (IAV) infection models, we analyzed cilia-driven flow and ciliary beat frequency (CBF) in the airway epithelium to evaluate MCC. Short-term IAV infection increased cilia-driven flow and CBF in control mice, but not in high-fat diet-induced obese mice. Basal cilia-driven flow and CBF were also lower in obese mice than in control mice. Mechanistically, the increase of extracellular adenosine triphosphate (ATP) release during IAV infection, which was observed in the control mice, was abolished in the obese mice; however, the addition of ATP increased cilia-driven flow and CBF both in control and obese mice to a similar extent. In addition, RNA sequencing and reverse transcription-polymerase chain reaction revealed the downregulation of several cilia-related genes, including Dnah1, Dnal1, Armc4, and Ttc12 (the dynein-related genes); Ulk4 (the polychaete differentiation gene); Cep164 (the ciliogenesis and intraflagellar transport gene); Rsph4a, Cfap206, and Ppil6 (the radial spoke structure and assembly gene); and Drc3(the nexin-dynein regulatory complex genes) in obese murine tracheal tissues compared with their control levels. In conclusion, our studies demonstrate that obesity attenuates MCC under basal conditions and during IAV infection by downregulating the expression of cilia-related genes and suppressing the release of extracellular ATP, thereby increasing the susceptibility and severity of IAV infection. NEW & NOTEWORTHY: Our study shows that obesity impairs airway mucociliary clearance (MCC), an essential physical innate defense mechanism for viral infection. Mechanically, this is likely due to the obesity-induced downregulation of cilia-related genes and attenuation of extracellular ATP release. This study provides novel insights into the mechanisms driving the higher susceptibility and severity of viral respiratory infections in individuals with obesity. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

17. Characterization of BRAF Thr599dup Mutation as a Targetable Driver Mutation Identified in Lung Adenocarcinoma by Comprehensive Genomic Profiling.

Author

Watanabe, Hirofumi, Inoue, Yusuke, Karayama, Masato, Yazawa, Shusuke, Mochizuka, Yasutaka, Yasui, Hideki, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, Shinmura, Kazuya, Inui, Naoki, and Suda, Takafumi

Abstract

PURPOSE: Understanding the function of BRAF mutants is crucial for determining the best treatment strategy. This study aimed to characterize a rare BRAF variant, BRAF Thr599dup, which was identified in a patient with lung adenocarcinoma (LUAD) by comprehensive genomic profiling. MATERIALS AND METHODS: We report a case of LUAD with BRAF Thr599dup treated with dabrafenib and trametinib. We conditionally expressed wild-type BRAF, BRAFV600E, or BRAFThr599dup in Ba/F3 cells and BEAS-2B cells. Ba/F3 cells carrying double-mutant BRAF (BRAFThr599dup/R509H, BRAFV600E/R509H, or BRAFK601E/R509H) that lacked the dimerizing ability were also established. Knockout of endogenous BRAF or CRAF in Ba/F3-BRAFThr599dup cells and Ba/F3-BRAFV600E cells was performed using the CRISPR/Cas9 system. Cell viability, mitogen-activated protein kinase (MAPK) signaling activity, and sensitivity to dabrafenib and trametinib were evaluated. RESULTS: The patient was revealed to have BRAF Thr599dup-positive tumor cells as a predominant clone, and dabrafenib and trametinib treatment showed modest efficacy. In Ba/F3 cells, both BRAFThr599dup and BRAFV600E similarly caused interleukin-3–independent proliferation and activated the MAPK pathway. Moreover, BRAFThr599dup and BRAFV600E similarly caused a significant increase in the anchorage-independent growth ability of BEAS-2B cells. Along with Ba/F3-BRAFV600E cells, Ba/F3-BRAFThr599dup cells were highly sensitive to a monomer-specific BRAF inhibitor, dabrafenib, with a half-maximal inhibitory concentration value of 29.7 nM. In the absence of wild-type BRAF, wild-type CRAF, or an intact dimer interface, the ability to induce oncogenic addiction and MAPK pathway activation in Ba/F3-BRAFThr599dup cells was not affected, which was in contrast to the findings in the BRAFK601E/R509H double-mutant model. CONCLUSION: BRAF Thr599dup is a potent driver oncogene that activates the MAPK pathway without the requirement for dimerization in vitro. Because BRAF Thr599dup has been recurrently reported across various cancer types, our findings should be further investigated both mechanistically and clinically. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

20. Assessment of Immune-Related Interstitial Lung Disease in Patients With NSCLC Treated with Immune Checkpoint Inhibitors: A Multicenter Prospective Study

Author

Suzuki, Yuzo, Karayama, Masato, Uto, Tomohiro, Fujii, Masato, Matsui, Takashi, Asada, Kazuhiro, Kusagaya, Hideki, Kato, Masato, Matsuda, Hiroyuki, Matsuura, Shun, Toyoshima, Mikio, Mori, Kazutaka, Ito, Yasuhiro, Koyauchi, Takafumi, Yasui, Hideki, Hozumi, Hironao, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, Nakamura, Yutaro, Inui, Naoki, and Suda, Takafumi

Published
2020
Full Text
View/download PDF

21. CT assessment of the normal upper-lobe lung volume in idiopathic pleuroparenchymal fibroelastosis

Author

Suzuki, Yuzo, primary, Kono, Masato, additional, Hasegawa, Hirotsugu, additional, Hashimoto, Dai, additional, Yokomura, Koshi, additional, Inoue, Yusuke, additional, Yasui, Hideki, additional, Hozumi, Hironao, additional, Karayama, Masato, additional, Furuhashi, Kazuki, additional, Enomoto, Noriyuki, additional, Fujisawa, Tomoyuki, additional, Inui, Naoki, additional, and Suda, Takafumi, additional

Published
2024
Full Text
View/download PDF

22. Erlotinib and bevacizumab in elderly patients ≥75 years old with non-small cell lung cancer harboring epidermal growth factor receptor mutations

Author

Aoshima, Yoichiro, Karayama, Masato, Inui, Naoki, Yasui, Hideki, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Fujisawa, Tomoyuki, Enomoto, Noriyuki, Nakamura, Yutaro, Mikamo, Masashi, Matsuura, Shun, Kusagaya, Hideki, Kaida, Yusuke, Uto, Tomohiro, Hashimoto, Dai, Matsui, Takashi, Asada, Kazuhiro, and Suda, Takafumi

Published
2021
Full Text
View/download PDF

23. Prognostic role of interferon‐lambda 3 in anti‐MDA5–positive dermatomyositis‐associated ILD

Author

Fukada, Atsuki, primary, Fujisawa, Tomoyuki, additional, Hozumi, Hironao, additional, Koda, Keigo, additional, Akamatsu, Taisuke, additional, Oyama, Yoshiyuki, additional, Satake, Yasuomi, additional, Niwa, Mitsuru, additional, Kaida, Yusuke, additional, Matsuda, Hiroyuki, additional, Yokomura, Koshi, additional, Koshimizu, Naoki, additional, Toyoshima, Mikio, additional, Imokawa, Shiro, additional, Hashimoto, Dai, additional, Yoshida, Akira, additional, Gono, Takahisa, additional, Kuwana, Masataka, additional, Yamano, Yasuhiko, additional, Kondoh, Yasuhiro, additional, Yamashita, Keita, additional, Maekawa, Masato, additional, Mori, Kazutaka, additional, Inoue, Yusuke, additional, Yasui, Hideki, additional, Suzuki, Yuzo, additional, Karayama, Masato, additional, Furuhashi, Kazuki, additional, Enomoto, Noriyuki, additional, Inui, Naoki, additional, and Suda, Takafumi, additional

Published
2023
Full Text
View/download PDF

28. Impact of bronchoalveolar lavage lymphocytosis on the effects of anti-inflammatory therapy in idiopathic non-specific interstitial pneumonia, idiopathic pleuroparenchymal fibroelastosis, and unclassifiable idiopathic interstitial pneumonia

Author

Yamagata, Akira, Arita, Machiko, Tachibana, Hiromasa, Tokioka, Fumiaki, Sugimoto, Chikatoshi, Sumikawa, Hiromitsu, Tanaka, Tomonori, Yasui, Hideki, Fujisawa, Tomoyuki, Nakamura, Yutaro, Suda, Takafumi, and Ishida, Tadashi

Published
2021
Full Text
View/download PDF

31. Clinical Outcomes of Anti-programmed Death-1 Antibody–Related Pneumonitis in Patients with Non-Small Cell Lung Cancer

Author

Koyauchi, Takafumi, Inui, Naoki, Karayama, Masato, Kitahara, Yoshihiro, Takuma, Sho, Amano, Yusuke, Yasui, Hideki, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Fujisawa, Tomoyuki, Enomoto, Noriyuki, Nakamura, Yutaro, Niwa, Mitsuru, Inami, Nao, Ito, Yasuhiro, Kusagaya, Hideki, Matsuura, Shun, Kaida, Yusuke, Uto, Tomohiro, Hashimoto, Dai, Matsui, Takashi, Asada, Kazuhiro, Matsuda, Hiroyuki, Fujii, Masato, Toyoshima, Mikio, and Suda, Takafumi

Published
2020
Full Text
View/download PDF

33. Prognostic impact of an early marginal decline in forced vital capacity in idiopathic pulmonary fibrosis patients treated with pirfenidone

Author

Kono, Masato, Nakamura, Yutaro, Enomoto, Noriyuki, Saito, Go, Koyanagi, Yu, Miyashita, Koichi, Tsutsumi, Akari, Kobayashi, Takeshi, Yasui, Hideki, Hozumi, Hironao, Karayama, Masato, Suzuki, Yuzo, Furuhashi, Kazuki, Miki, Yoshihiro, Hashimoto, Dai, Fujisawa, Tomoyuki, Inui, Naoki, Suda, Takafumi, and Nakamura, Hidenori

Published
2019
Full Text
View/download PDF

36. Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae

Author

Kato, Taichi, Imada, Akira, Uemura, Makoto, Nogami, Daisaku, Maehara, Hiroyuki, Ishioka, Ryoko, Baba, Hajime, Matsumoto, Katsura, Iwamatsu, Hidetoshi, Kubota, Kaori, Sugiyasu, Kei, Soejima, Yuichi, Moritani, Yuuki, Ohshima, Tomohito, Ohashi, Hiroyuki, Tanaka, Junpei, Sasada, Mahito, Arai, Akira, Nakajima, Kazuhiro, Kiyota, Seiichiro, Tanabe, Kenji, Imamura, Kayuyoshi, Kunitomi, Nanae, Kunihiro, Kenji, Taguchi, Hiroki, Koizumi, Mitsuo, Yamada, Norimi, Nishi, Yuichi, Kida, Mayumi, Tanaka, Sawa, Ueoka, Rie, Yasui, Hideki, Maruoka, Koichi, Henden, Arne, Oksanen, Arto, Moilanen, Marko, Tikkanen, Petri, Aho, Mika, Monard, Berto, Itoh, Hiroshi, Dubovsky, Pavol A., Kudzej, Igor, Dancikova, Radka, Vanmunster, Tonny, Pietz, Jochen, Bolt, Greg, Boyd, David, Nelson, Peter, Krajci, Thomas, Cook, Lewis M., Torii, Ken'ichi, Starkey, Donn R., Shears, Jeremy, Jensen, Lasse-Teist, Masi, Gianluca, Novak, Rudolf, Hynek, Tomas, Kocian, Radek, Kral, Lukas, Kucakova, Hana, Kolasa, Marek, Stastny, Petr, and Staels, Bart

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We systematically surveyed period variations of superhumps in SU UMa-type dwarf novae based on newly obtained data and past publications. In many systems, the evolution of superhump period are found to be composed of three distinct stages: early evolutionary stage with a longer superhump period, middle stage with systematically varying periods, final stage with a shorter, stable superhump period. During the middle stage, many systems with superhump periods less than 0.08 d show positive period derivatives. Contrary to the earlier claim, we found no clear evidence for variation of period derivatives between superoutburst of the same object. We present an interpretation that the lengthening of the superhump period is a result of outward propagation of the eccentricity wave and is limited by the radius near the tidal truncation. We interpret that late stage superhumps are rejuvenized excitation of 3:1 resonance when the superhumps in the outer disk is effectively quenched. Many of WZ Sge-type dwarf novae showed long-enduring superhumps during the post-superoutburst stage having periods longer than those during the main superoutburst. The period derivatives in WZ Sge-type dwarf novae are found to be strongly correlated with the fractional superhump excess, or consequently, mass ratio. WZ Sge-type dwarf novae with a long-lasting rebrightening or with multiple rebrightenings tend to have smaller period derivatives and are excellent candidate for the systems around or after the period minimum of evolution of cataclysmic variables (abridged)., Comment: 239 pages, 225 figures, PASJ accepted

Published
2009
Full Text
View/download PDF

37. Association of the lung immune prognostic index with the survival of patients with idiopathic interstitial pneumonias

Author

Suzuki, Takahito, primary, Karayama, Masato, additional, Aoshima, Yoichiro, additional, Mori, Kazutaka, additional, Yoshizawa, Nobuko, additional, Ichikawa, Shintaro, additional, Kato, Shinpei, additional, Yokomura, Koshi, additional, Kono, Masato, additional, Hashimoto, Dai, additional, Inoue, Yusuke, additional, Yasui, Hideki, additional, Hozumi, Hironao, additional, Suzuki, Yuzo, additional, Furuhashi, Kazuki, additional, Fujisawa, Tomoyuki, additional, Enomoto, Noriyuki, additional, Goshima, Satoshi, additional, Inui, Naoki, additional, and Suda, Takafumi, additional

Published
2023
Full Text
View/download PDF

38. “Bull’s-Eye” Sign and Its Longitudinal Change on HRCT in Pulmonary Sarcoidosis

Author

Mochizuka, Yasutaka, primary, Enomoto, Noriyuki, additional, Daisuke, Akahori, additional, Inoue, Yusuke, additional, Yasui, Hideki, additional, Hozumi, Hironao, additional, Suzuki, Yuzo, additional, Karayama, Masato, additional, Furuhashi, Kazuki, additional, Katsumata, Mineo, additional, Hashimoto, Dai, additional, Imokawa, Shiro, additional, Fujisawa, Tomoyuki, additional, Inui, Naoki, additional, Nakamura, Yutaro, additional, Tabata, Kazuhiro, additional, Johkoh, Takeshi, additional, and Suda, Takafumi, additional

Published
2023
Full Text
View/download PDF

41. Distinctive characteristics and prognostic significance of interstitial pneumonia with autoimmune features in patients with chronic fibrosing interstitial pneumonia

Author

Yoshimura, Katsuhiro, Kono, Masato, Enomoto, Yasunori, Nishimoto, Koji, Oyama, Yoshiyuki, Yasui, Hideki, Hozumi, Hironao, Karayama, Masato, Suzuki, Yuzo, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, Nakamura, Yutaro, Inui, Naoki, Sumikawa, Hiromitsu, Johkoh, Takeshi, Colby, Thomas V., Sugimura, Haruhiko, and Suda, Takafumi

Published
2018
Full Text
View/download PDF

43. Switch maintenance therapy with S-1 after induction therapy with carboplatin and nanoparticle albumin-bound paclitaxel in advanced lung squamous cell carcinoma

Author

Akiyama, Norimichi, Karayama, Masato, Inui, Naoki, Yasui, Hideki, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Fujisawa, Tomoyuki, Enomoto, Noriyuki, Nakamura, Yutaro, Inami, Nao, Matsuura, Shun, Kaida, Yusuke, Uto, Tomohiro, Matsui, Takashi, Asada, Kazuhiro, Matsuda, Hiroyuki, Fujii, Masato, Toyoshima, Mikio, and Suda, Takafumi

Published
2019
Full Text
View/download PDF

44. Clinical diagnosis of idiopathic pleuroparenchymal fibroelastosis: A retrospective multicenter study

Author

Enomoto, Yasunori, Nakamura, Yutaro, Satake, Yasuomi, Sumikawa, Hiromitsu, Johkoh, Takeshi, Colby, Thomas V., Yasui, Hideki, Hozumi, Hironao, Karayama, Masato, Suzuki, Yuzo, Furuhashi, Kazuki, Fujisawa, Tomoyuki, Enomoto, Noriyuki, Inui, Naoki, Iwashita, Toshihide, Kuroishi, Shigeki, Yokomura, Koshi, Koshimizu, Naoki, Toyoshima, Mikio, Imokawa, Shiro, Yamada, Takashi, Shirai, Toshihiro, Hayakawa, Hiroshi, and Suda, Takafumi

Published
2017
Full Text
View/download PDF

45. Six-week oral prednisolone therapy for immune-related pneumonitis: a single-arm phase II study

Author

Karayama, Masato, primary, Inui, Naoki, additional, Inoue, Yusuke, additional, Yasui, Hideki, additional, Hozumi, Hironao, additional, Suzuki, Yuzo, additional, Furuhashi, Kazuki, additional, Fujisawa, Tomoyuki, additional, Enomoto, Noriyuki, additional, Asada, Kazuhiro, additional, Uto, Tomohiro, additional, Fujii, Masato, additional, Matsui, Takashi, additional, Matsuura, Shun, additional, Hashimoto, Dai, additional, Toyoshima, Mikio, additional, Ikeda, Masaki, additional, Matsuda, Hiroyuki, additional, Inami, Nao, additional, Kaida, Yusuke, additional, Funayama, Satoshi, additional, Ichikawa, Shintaro, additional, Goshima, Satoshi, additional, and Suda, Takafumi, additional

Published
2023
Full Text
View/download PDF

49. Association of the lung immune prognostic index with the survival of patients with idiopathic interstitial pneumonias.

Author

Suzuki, Takahito, Karayama, Masato, Aoshima, Yoichiro, Mori, Kazutaka, Yoshizawa, Nobuko, Ichikawa, Shintaro, Kato, Shinpei, Yokomura, Koshi, Kono, Masato, Hashimoto, Dai, Inoue, Yusuke, Yasui, Hideki, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Fujisawa, Tomoyuki, Enomoto, Noriyuki, Goshima, Satoshi, Inui, Naoki, and Suda, Takafumi

Subjects
IDIOPATHIC interstitial pneumonias, OVERALL survival, IDIOPATHIC pulmonary fibrosis, LUNGS, NEUTROPHIL lymphocyte ratio
Abstract

Background and Objective: The lung immune prognostic index (LIPI), a simple index calculated from the blood lactate dehydrogenase level and derived neutrophil‐to‐lymphocyte ratio, is thought to be associated with host immune status. However, the utility of LIPI in patients with idiopathic interstitial pneumonias (IIPs) is unknown. Methods: In this multicentre, retrospective, observational study, an association between LIPI and the survival of patients with IIPs was evaluated. Results: Exploratory and validation cohorts consisting of 460 and 414 patients with IIPs, respectively, were included (159 and 159 patients had idiopathic pulmonary fibrosis [IPF], and 301 and 255 had non‐IPF, respectively). In the exploratory cohort, patients with IPF and a low LIPI had significantly better survival than those with a high LIPI (median of 5.6 years vs. 3.9 years, p = 0.016). The predictive ability of LIPI for the survival of patients with IPF was validated in the validation cohort (median of 8.5 years vs. 4.4 years, p = 0.003). In a multivariate Cox proportional hazard analysis, LIPI was selected as an independent predictive factor for the survival of IPF patients. There was no significant association between LIPI and survival of non‐IPF patients in the exploratory and validation cohorts. Conclusion: The LIPI was a predictive factor for the survival of patients with IPF and could aid the management of IPF. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results