301 results on '"Yasuda, Clarissa L."'
Search Results
2. Junctional instability in neuroepithelium and network hyperexcitability in a focal cortical dysplasia human model
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Avansini, Simoni H, Puppo, Francesca, Adams, Jason W, Vieira, Andre S, Coan, Ana C, Rogerio, Fabio, Torres, Fabio R, Araújo, Patricia AOR, Martin, Mariana, Montenegro, Maria A, Yasuda, Clarissa L, Tedeschi, Helder, Ghizoni, Enrico, França, Andréa FEC, Alvim, Marina KM, Athié, Maria C, Rocha, Cristiane S, Almeida, Vanessa S, Dias, Elayne V, Delay, Lauriane, Molina, Elsa, Yaksh, Tony L, Cendes, Fernando, Lopes Cendes, Iscia, and Muotri, Alysson R
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Congenital Structural Anomalies ,Pediatric ,Neurosciences ,Aetiology ,1.1 Normal biological development and functioning ,2.1 Biological and endogenous factors ,Underpinning research ,Neurological ,Brain ,Epilepsy ,Humans ,Infant ,Newborn ,Malformations of Cortical Development ,Malformations of Cortical Development ,Group I ,Neurons ,focal cortical dysplasia ,cortical organoids ,cell adhesion ,cell proliferation ,neuronal network ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery - Abstract
Focal cortical dysplasia is a highly epileptogenic cortical malformation with few treatment options. Here, we generated human cortical organoids from patients with focal cortical dysplasia type II. Using this human model, we mimicked some focal cortical dysplasia hallmarks, such as impaired cell proliferation, the presence of dysmorphic neurons and balloon cells, and neuronal network hyperexcitability. Furthermore, we observed alterations in the adherens junctions zonula occludens-1 and partitioning defective 3, reduced polarization of the actin cytoskeleton, and fewer synaptic puncta. Focal cortical dysplasia cortical organoids showed downregulation of the small GTPase RHOA, a finding that was confirmed in brain tissue resected from these patients. Functionally, both spontaneous and optogenetically-evoked electrical activity revealed hyperexcitability and enhanced network connectivity in focal cortical dysplasia organoids. Taken together, our findings suggest a ventricular zone instability in tissue cohesion of neuroepithelial cells, leading to a maturational arrest of progenitors or newborn neurons, which may predispose to cellular and functional immaturity and compromise the formation of neural networks in focal cortical dysplasia.
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- 2022
3. Identifying cellular markers of focal cortical dysplasia type II with cell-type deconvolution and single-cell signatures
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Galvão, Isabella C., Kandratavicius, Ludmyla, Messias, Lauana A., Athié, Maria C. P., Assis-Mendonça, Guilherme R., Alvim, Marina K. M., Ghizoni, Enrico, Tedeschi, Helder, Yasuda, Clarissa L., Cendes, Fernando, Vieira, André S., Rogerio, Fabio, Lopes-Cendes, Iscia, and Veiga, Diogo F. T.
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- 2023
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4. Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression
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Larivière, Sara, Royer, Jessica, Rodríguez-Cruces, Raúl, Paquola, Casey, Caligiuri, Maria Eugenia, Gambardella, Antonio, Concha, Luis, Keller, Simon S, Cendes, Fernando, Yasuda, Clarissa L, Bonilha, Leonardo, Gleichgerrcht, Ezequiel, Focke, Niels K, Domin, Martin, von Podewills, Felix, Langner, Soenke, Rummel, Christian, Wiest, Roland, Martin, Pascal, Kotikalapudi, Raviteja, O’Brien, Terence J, Sinclair, Benjamin, Vivash, Lucy, Desmond, Patricia M, Lui, Elaine, Vaudano, Anna Elisabetta, Meletti, Stefano, Tondelli, Manuela, Alhusaini, Saud, Doherty, Colin P, Cavalleri, Gianpiero L, Delanty, Norman, Kälviäinen, Reetta, Jackson, Graeme D, Kowalczyk, Magdalena, Mascalchi, Mario, Semmelroch, Mira, Thomas, Rhys H, Soltanian-Zadeh, Hamid, Davoodi-Bojd, Esmaeil, Zhang, Junsong, Winston, Gavin P, Griffin, Aoife, Singh, Aditi, Tiwari, Vijay K, Kreilkamp, Barbara AK, Lenge, Matteo, Guerrini, Renzo, Hamandi, Khalid, Foley, Sonya, Rüber, Theodor, Weber, Bernd, Depondt, Chantal, Absil, Julie, Carr, Sarah JA, Abela, Eugenio, Richardson, Mark P, Devinsky, Orrin, Severino, Mariasavina, Striano, Pasquale, Tortora, Domenico, Kaestner, Erik, Hatton, Sean N, Vos, Sjoerd B, Caciagli, Lorenzo, Duncan, John S, Whelan, Christopher D, Thompson, Paul M, Sisodiya, Sanjay M, Bernasconi, Andrea, Labate, Angelo, McDonald, Carrie R, Bernasconi, Neda, and Bernhardt, Boris C
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Neurodegenerative ,Genetics ,Neurosciences ,Brain Disorders ,Epilepsy ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Adult ,Connectome ,Epilepsy ,Generalized ,Epilepsy ,Temporal Lobe ,Gene Expression ,Humans ,Immunoglobulin E ,Magnetic Resonance Imaging ,Nerve Net - Abstract
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined whole-brain structural covariance networks in patients with epilepsy and related findings to postmortem epilepsy risk gene expression patterns. Brain network analysis included 578 adults with temporal lobe epilepsy (TLE), 288 adults with idiopathic generalized epilepsy (IGE), and 1328 healthy controls from 18 centres worldwide. Graph theoretical analysis of structural covariance networks revealed increased clustering and path length in orbitofrontal and temporal regions in TLE, suggesting a shift towards network regularization. Conversely, people with IGE showed decreased clustering and path length in fronto-temporo-parietal cortices, indicating a random network configuration. Syndrome-specific topological alterations reflected expression patterns of risk genes for hippocampal sclerosis in TLE and for generalized epilepsy in IGE. These imaging-transcriptomic signatures could potentially guide diagnosis or tailor therapeutic approaches to specific epilepsy syndromes.
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- 2022
5. White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study
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Hatton, Sean N, Huynh, Khoa H, Bonilha, Leonardo, Abela, Eugenio, Alhusaini, Saud, Altmann, Andre, Alvim, Marina KM, Balachandra, Akshara R, Bartolini, Emanuele, Bender, Benjamin, Bernasconi, Neda, Bernasconi, Andrea, Bernhardt, Boris, Bargallo, Núria, Caldairou, Benoit, Caligiuri, Maria E, Carr, Sarah JA, Cavalleri, Gianpiero L, Cendes, Fernando, Concha, Luis, Davoodi-bojd, Esmaeil, Desmond, Patricia M, Devinsky, Orrin, Doherty, Colin P, Domin, Martin, Duncan, John S, Focke, Niels K, Foley, Sonya F, Gambardella, Antonio, Gleichgerrcht, Ezequiel, Guerrini, Renzo, Hamandi, Khalid, Ishikawa, Akari, Keller, Simon S, Kochunov, Peter V, Kotikalapudi, Raviteja, Kreilkamp, Barbara AK, Kwan, Patrick, Labate, Angelo, Langner, Soenke, Lenge, Matteo, Liu, Min, Lui, Elaine, Martin, Pascal, Mascalchi, Mario, Moreira, José CV, Morita-Sherman, Marcia E, O’Brien, Terence J, Pardoe, Heath R, Pariente, José C, Ribeiro, Letícia F, Richardson, Mark P, Rocha, Cristiane S, Rodríguez-Cruces, Raúl, Rosenow, Felix, Severino, Mariasavina, Sinclair, Benjamin, Soltanian-Zadeh, Hamid, Striano, Pasquale, Taylor, Peter N, Thomas, Rhys H, Tortora, Domenico, Velakoulis, Dennis, Vezzani, Annamaria, Vivash, Lucy, von Podewils, Felix, Vos, Sjoerd B, Weber, Bernd, Winston, Gavin P, Yasuda, Clarissa L, Zhu, Alyssa H, Thompson, Paul M, Whelan, Christopher D, Jahanshad, Neda, Sisodiya, Sanjay M, and McDonald, Carrie R
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Genetics ,Neurodegenerative ,Epilepsy ,Clinical Research ,Brain Disorders ,Neurosciences ,Biomedical Imaging ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Adult ,Brain ,Diffusion Magnetic Resonance Imaging ,Epileptic Syndromes ,Female ,Humans ,Image Interpretation ,Computer-Assisted ,Male ,Middle Aged ,White Matter ,epilepsy ,diffusion tensor imaging ,multisite analysis ,white matter ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery - Abstract
The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, including temporal lobe epilepsy, extratemporal epilepsy, and genetic generalized epilepsy. Our goal was to rank the most robust white matter microstructural differences across and within syndromes in a multicentre sample of adult epilepsy patients. Diffusion-weighted MRI data were analysed from 1069 healthy controls and 1249 patients: temporal lobe epilepsy with hippocampal sclerosis (n = 599), temporal lobe epilepsy with normal MRI (n = 275), genetic generalized epilepsy (n = 182) and non-lesional extratemporal epilepsy (n = 193). A harmonized protocol using tract-based spatial statistics was used to derive skeletonized maps of fractional anisotropy and mean diffusivity for each participant, and fibre tracts were segmented using a diffusion MRI atlas. Data were harmonized to correct for scanner-specific variations in diffusion measures using a batch-effect correction tool (ComBat). Analyses of covariance, adjusting for age and sex, examined differences between each epilepsy syndrome and controls for each white matter tract (Bonferroni corrected at P
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- 2020
6. A worldwide ENIGMA study on epilepsy-related gray and white matter compromise across the adult lifespan
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Chen, Judy, primary, Ngo, Alexander, additional, Rodríguez-Cruces, Raúl, additional, Royer, Jessica, additional, Caligiuri, Maria Eugenia, additional, Gambardella, Antonio, additional, Concha, Luis, additional, Keller, Simon S., additional, Cendes, Fernando, additional, Yasuda, Clarissa L., additional, Alvim, Marina K. M., additional, Bonilha, Leonardo, additional, Gleichgerrcht, Ezequiel, additional, Focke, Niels K., additional, Kreilkamp, Barbara, additional, Domin, Martin, additional, von Podewils, Felix, additional, Langner, Soenke, additional, Rummel, Christian, additional, Wiest, Roland, additional, Martin, Pascal, additional, Kotikalapudi, Raviteja, additional, Bender, Benjamin, additional, O’Brien, Terence J., additional, Sinclair, Benjamin, additional, Vivash, Lucy, additional, Kwan, Patrick, additional, Desmond, Patricia M., additional, Lui, Elaine, additional, Duma, Gian Marco, additional, Bonanni, Paolo, additional, Ballerini, Alice, additional, Vaudano, Anna Elisabetta, additional, Meletti, Stefano, additional, Tondelli, Manuela, additional, Alhusaini, Saud, additional, Doherty, Colin P., additional, Cavalleri, Gianpiero L., additional, Delanty, Norman, additional, Kälviäinen, Reetta, additional, Jackson, Graeme D., additional, Kowalczyk, Magdalena, additional, Mascalchi, Mario, additional, Semmelroch, Mira, additional, Thomas, Rhys H., additional, Soltanian-Zadeh, Hamid, additional, Davoodi-Bojd, Esmaeil, additional, Zhang, Junsong, additional, Lenge, Matteo, additional, Guerrini, Renzo, additional, Bartolini, Emanuele, additional, Hamandi, Khalid, additional, Foley, Sonya, additional, Rüber, Theodor, additional, Bauer, Tobias, additional, Weber, Bernd, additional, Caldairou, Benoit, additional, Depondt, Chantal, additional, Absil, Julie, additional, Carr, Sarah J. A., additional, Abela, Eugenio, additional, Richardson, Mark P., additional, Devinsky, Orrin, additional, Pardoe, Heath, additional, Severino, Mariasavina, additional, Striano, Pasquale, additional, Tortora, Domenico, additional, Kaestner, Erik, additional, Hatton, Sean N., additional, Arienzo, Donatello, additional, Vos, Sjoerd B., additional, Ryten, Mina, additional, Taylor, Peter N., additional, Duncan, John S., additional, Whelan, Christopher D., additional, Galovic, Marian, additional, Winston, Gavin P., additional, Thomopoulos, Sophia I., additional, Thompson, Paul M., additional, Sisodiya, Sanjay M., additional, Labate, Angelo, additional, McDonald, Carrie R., additional, Caciagli, Lorenzo, additional, Bernasconi, Neda, additional, Bernasconi, Andrea, additional, Larivière, Sara, additional, Schrader, Dewi, additional, and Bernhardt, Boris C., additional
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- 2024
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7. Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA‐Epilepsy study
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Kerestes, Rebecca, primary, Perry, Andrew, additional, Vivash, Lucy, additional, O'Brien, Terence J., additional, Alvim, Marina K. M., additional, Arienzo, Donatello, additional, Aventurato, Ítalo K., additional, Ballerini, Alice, additional, Baltazar, Gabriel F., additional, Bargalló, Núria, additional, Bender, Benjamin, additional, Brioschi, Ricardo, additional, Bürkle, Eva, additional, Caligiuri, Maria Eugenia, additional, Cendes, Fernando, additional, de Tisi, Jane, additional, Duncan, John S., additional, Engel, Jerome P., additional, Foley, Sonya, additional, Fortunato, Francesco, additional, Gambardella, Antonio, additional, Giacomini, Thea, additional, Guerrini, Renzo, additional, Hall, Gerard, additional, Hamandi, Khalid, additional, Ives‐Deliperi, Victoria, additional, João, Rafael B., additional, Keller, Simon S., additional, Kleiser, Benedict, additional, Labate, Angelo, additional, Lenge, Matteo, additional, Marotta, Cassandra, additional, Martin, Pascal, additional, Mascalchi, Mario, additional, Meletti, Stefano, additional, Owens‐Walton, Conor, additional, Parodi, Costanza B., additional, Pascual‐Diaz, Saül, additional, Powell, David, additional, Rao, Jun, additional, Rebsamen, Michael, additional, Reiter, Johannes, additional, Riva, Antonella, additional, Rüber, Theodor, additional, Rummel, Christian, additional, Scheffler, Freda, additional, Severino, Mariasavina, additional, Silva, Lucas S., additional, Staba, Richard J., additional, Stein, Dan J., additional, Striano, Pasquale, additional, Taylor, Peter N., additional, Thomopoulos, Sophia I., additional, Thompson, Paul M., additional, Tortora, Domenico, additional, Vaudano, Anna Elisabetta, additional, Weber, Bernd, additional, Wiest, Roland, additional, Winston, Gavin P., additional, Yasuda, Clarissa L., additional, Zheng, Hong, additional, McDonald, Carrie R., additional, Sisodiya, Sanjay M., additional, and Harding, Ian H., additional
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- 2024
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8. Longitudinal analysis of interictal electroencephalograms in patients with temporal lobe epilepsy with hippocampal sclerosis
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Brito, Mariana R., Prado, Thiago S., Alvim, Marina K.M., Santos, Lucas S.R., Morita-Sherman, Marcia, Yasuda, Clarissa L., and Cendes, Fernando
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- 2021
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9. Revisiting the clinical impact of variants in EFHC1 in patients with different phenotypes of genetic generalized epilepsy
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Gonsales, Marina C., Ribeiro, Patrícia A.O., Betting, Luiz E., Alvim, Marina K.M., Guerreiro, Carlos M., Yasuda, Clarissa L., Gitaí, Daniel L.G., Cendes, Fernando, and Lopes-Cendes, Iscia
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- 2020
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10. Role of the glymphatic system and perivascular spaces as a potential biomarker for post‐stroke epilepsy
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Hlauschek, Gernot, primary, Nicolo, John‐Paul, additional, Sinclair, Benjamin, additional, Law, Meng, additional, Yasuda, Clarissa L., additional, Cendes, Fernando, additional, Lossius, Morten Ingvar, additional, Kwan, Patrick, additional, and Vivash, Lucy, additional
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- 2023
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11. Clinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR)
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Mishra, Nishant K, primary, Kwan, Patrick, additional, Tanaka, Tomotaka, additional, Sunnerhagen, Katharina S, additional, Dawson, Jesse, additional, Zhao, Yize, additional, Misra, Shubham, additional, Wang, Selena, additional, Sharma, Vijay K, additional, Mazumder, Rajarshi, additional, Funaro, Melissa C, additional, Ihara, Masafumi, additional, Nicolo, John-Paul, additional, Liebeskind, David S, additional, Yasuda, Clarissa L, additional, Cendes, Fernando, additional, Quinn, Terence J, additional, Ge, Zongyuan, additional, Scalzo, Fabien, additional, Zelano, Johan, additional, and Kasner, Scott E, additional
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- 2023
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12. Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA-Epilepsy study
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Kerestes, Rebecca, primary, Perry, Andrew, additional, Vivash, Lucy, additional, O'Brien, Terence, additional, Alvim, Marina K.M., additional, Arienzo, Donatello, additional, Aventurato, Ìtalo K., additional, Ballerini, Alice, additional, Baltazar, Gabriel F., additional, Bargalló, Núria, additional, Bender, Benjamin, additional, Brioschi, Ricardo, additional, Bürkle, Eva, additional, Caligiuri, Maria Eugenia, additional, Cendes, Fernando, additional, de Tisi, Jane, additional, Duncan, John S., additional, Engel, Jerome P., additional, Foley, Sonya, additional, Fortunato, Francesco, additional, Gambardella, Antonio, additional, Giacomini, Thea, additional, Guerrini, Renzo, additional, Hall, Gerard, additional, Hamandi, Khalid, additional, Ives-Deliperi, Victoria, additional, João, Rafael B., additional, Keller, Simon S., additional, Kleiser, Benedict, additional, Labate, Angelo, additional, Lenge, Matteo, additional, Marotta, Cassandra, additional, Martin, Pascal, additional, Mascalchi, Mario, additional, Meletti, Stefano, additional, Owens-Walton, Conor, additional, Parodi, Costanza b., additional, Pascual-Diaz, Saül, additional, Powell, David, additional, Rao, Jun, additional, Rebsamen, Michael, additional, Reiter, Johannes, additional, Riva, Antonella, additional, Rüeber, Theodor, additional, Rummel, Christian, additional, Scheffler, Freda, additional, Severino, Mariasavina, additional, Silva, Lucas S., additional, Staba, Richard J., additional, Stein, Dan J., additional, Striano, Pasquale, additional, Taylor, Peter N., additional, Thomopoulos, Sophia I., additional, Thompson, Paul M., additional, Tortora, Domenico, additional, Vaudano, Anna Elisabetta, additional, Weber, Bernd I, additional, Wiest, Roland, additional, Winston, Gavin P., additional, Yasuda, Clarissa L., additional, Zheng, Hong, additional, McDonald, Carrie, additional, Sisodiya, Sanjay, additional, and Harding, Ian H., additional
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- 2023
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13. Role of the glymphatic system and perivascular spaces as a potential biomarker for post‐stroke epilepsy.
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Hlauschek, Gernot, Nicolo, John‐Paul, Sinclair, Benjamin, Law, Meng, Yasuda, Clarissa L., Cendes, Fernando, Lossius, Morten Ingvar, Kwan, Patrick, and Vivash, Lucy
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EPILEPSY ,NEUROLOGICAL disorders ,PARTIAL epilepsy ,OLDER patients ,PEOPLE with epilepsy ,VAGUS nerve - Abstract
Stroke is one of the most common causes of acquired epilepsy, which can also result in disability and increased mortality rates particularly in elderly patients. No preventive treatment for post‐stroke epilepsy is currently available. Development of such treatments has been greatly limited by the lack of biomarkers to reliably identify high‐risk patients. The glymphatic system, including perivascular spaces (PVS), is the brain's waste clearance system, and enlargement or asymmetry of PVS (ePVS) is hypothesized to play a significant role in the pathogenesis of several neurological conditions. In this article, we discuss potential mechanisms for the role of perivascular spaces in the development of post‐stroke epilepsy. Using advanced MR‐imaging techniques, it has been shown that there is asymmetry and impairment of glymphatic function in the setting of ischemic stroke. Furthermore, studies have described a dysfunction of PVS in patients with different focal and generalized epilepsy syndromes. It is thought that inflammatory processes involving PVS and the blood–brain barrier, impairment of waste clearance, and sustained hypertension affecting the glymphatic system during a seizure may play a crucial role in epileptogenesis post‐stroke. We hypothesize that impairment of the glymphatic system and asymmetry and dynamics of ePVS in the course of a stroke contribute to the development of PSE. Automated ePVS detection in stroke patients might thus assist in the identification of high‐risk patients for post‐stroke epilepsy trials. Plain Language Summary: Stroke often leads to epilepsy and is one of the main causes of epilepsy in elderly patients, with no preventative treatment available. The brain's waste removal system, called the glymphatic system which consists of perivascular spaces, may be involved. Enlargement or asymmetry of perivascular spaces could play a role in this and can be visualised with advanced brain imaging after a stroke. Detecting enlarged perivascular spaces in stroke patients could help identify those at risk for post‐stroke epilepsy. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Interactive patient-customized curvilinear reformatting for improving neurosurgical planning
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Wu, Shin-Ting, Loos, Wallace Souza, de Castro Oliveira, Dayvid Leonardo, Cendes, Fernando, Yasuda, Clarissa L., and Ghizoni, Enrico
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- 2019
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15. Identifying cellular markers of focal cortical dysplasia type II with cell-type deconvolution and single-cell signatures
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Galvao, Isabella C., primary, Kandratavicius, Ludmyla, additional, Messias, Lauana A., additional, Athie, Maria C. P., additional, Assis-Mendonca, Guilherme R., additional, Alvim, Marina K. M., additional, Ghizoni, Enrico, additional, Tedeschi, Helder, additional, Yasuda, Clarissa L., additional, Cendes, Fernando, additional, Vieira, Andre Schwambach, additional, Rogerio, Fabio, additional, Lopes-Cendes, Iscia, additional, and Veiga, Diogo F. Troggian, additional
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- 2023
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16. Development of a histologically validated segmentation protocol for the hippocampal body
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Steve, Trevor A., Yasuda, Clarissa L., Coras, Roland, Lail, Mohjevan, Blumcke, Ingmar, Livy, Daniel J., Malykhin, Nikolai, and Gross, Donald W.
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- 2017
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17. Post-COVID myocarditis with antiheart antibodies persistence:Clues for autoimmunity?
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Silva, Lucas S., de Oliveira Boldrini, Vinícius, Marques, Ana, Yasuda, Clarissa L., Silva, Lucas S., de Oliveira Boldrini, Vinícius, Marques, Ana, and Yasuda, Clarissa L.
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- 2023
18. Revealing the spatiotemporal requirements for accurate subject identification with resting-state functional connectivity: a simultaneous fNIRS-fMRI study
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Novi Junior, Sergio Luiz, primary, Carvalho, Alex De Castro, additional, Menezes Forti, Rodrigo M., additional, Cendes, Fernado, additional, Yasuda, Clarissa L., additional, and Mesquita, Rickson C., additional
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- 2023
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19. Post‐COVID myocarditis with antiheart antibodies persistence: Clues for autoimmunity?
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Silva, Lucas S., primary, Boldrini, Vinícius O., additional, Marques, Ana M., additional, and Yasuda, Clarissa L., additional
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- 2023
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20. Normal cerebral cortical thickness in first-degree relatives of temporal lobe epilepsy patients
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Alhusaini, Saud, Kowalczyk, Magdalena A., Yasuda, Clarissa L., Semmelroch, Mira K., Katsurayama, Marilise, Zabin, Matheus, Zanão, Tamires, Nogueira, Mateus H., Alvim, Marina K.M., Ferraz, Victória R., Tsai, Meng-Han, Fitzsimons, Mary, Lopes-Cendes, Iscia, Doherty, Colin P., Cavalleri, Gianpiero L., Cendes, Fernando, Jackson, Graeme D., and Delanty, Norman
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- 2019
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21. Gene expression profile suggests different mechanisms underlying sporadic and familial mesial temporal lobe epilepsy
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Maurer-Morelli, Claudia V, primary, de Vasconcellos, Jaira F, additional, Bruxel, Estela M, additional, Rocha, Cristiane S, additional, do Canto, Amanda M, additional, Tedeschi, Helder, additional, Yasuda, Clarissa L, additional, Cendes, Fernando, additional, and Lopes-Cendes, Iscia, additional
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- 2022
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22. Diffusion abnormalities of the corpus callosum in patients with malformations of cortical development and epilepsy
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Andrade, Celi S., Leite, Claudia C., Otaduy, Maria C.G., Lyra, Katarina P., Valente, Kette D.R., Yasuda, Clarissa L., Beltramini, Guilherme C., Beaulieu, Christian, and Gross, Donald W.
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- 2014
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23. Reproducibility in the absence of selective reporting : An illustration from large-scale brain asymmetry research
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Kong, Xiang-Zhen, Francks, Clyde, Allen, Nicholas B., Heslenfeld, Dirk, Hester, Robert, Hibar, Derrek Paul, Ho, Beng-Choon, Ho, Tiffany C., Hoekstra, Pieter J., Holst, Ruth J., Hoogman, Martine, Høvik, Marie F., Howells, Fleur M., Ames, David, Hugdahl, Kenneth, Huyser, Chaim, Ingvar, Martin, Ishikawa, Akari, James, Anthony, Jahanshad, Neda, Jernigan, Terry L., Jönsson, Erik G, Kaleda, Vasily, Kelly, Clare, Andreassen, Ole A., Kerich, Michael, Keshavan, Matcheri S., Khadka, Sabin, Kircher, Tilo, Kohls, Gregor, Konrad, Kerstin, Korucuoglu, Ozlem, Krämer, Bernd, Krug, Axel, Kuntsi, Jonna, Vasquez, Alejandro Arias, Kwon, Jun Soo, Lambregts-Rommelse, Nanda, Landén, Mikael, Lázaro, Luisa, Lebedeva, Irina, Lenroot, Rhoshel, Lesch, Klaus-Peter, Li, Qinqin, Lim, Kelvin O., Liu, Jia, Armstrong, Nicola J., Lochner, Christine, London, Edythe D., Lorenzetti, Valentina, Luciano, Michelle, Luijten, Maartje, Lundervold, Astri J., Mackey, Scott, MacMaster, Frank P., Maingault, Sophie, Malpas, Charles B., Asherson, Phil, Malt, Ulrik F., Mataix-Cols, David, Martin-Santos, Rocio, Mayer, Andrew R., McCarthy, Hazel, Medland, Sarah, Metha, Mitul, Mitchell, Philip B., Mueller, Bryon A., Maniega, Susana Muñoz, Bergo, Felipe, Mazoyer, Bernard, McDonald, Colm, McLellan, Quinn, McMahon, Katie L., McPhilemy, Genevieve, Momenan, Reza, Morales, Angelica M., Narayanaswamy, Janardhanan C., Moreira, José Carlos Vasques, Nerland, Stener, Bastin, Mark E., Nestor, Liam, Newman, Erik, Nigg, Joel T., Nordvik, Jan Egil, Novotny, Stephanie, Weiss, Eileen Oberwelland, O'Gorman, Ruth L., Oosterlaan, Jaap, Oranje, Bob, Orr, Catherine, Batalla, Albert, Overs, Bronwyn, Paloyelis, Yannis, Pauli, Paul, Paulus, Martin, Plessen, Kerstin Jessica, Polier, Georg G., Pomarol-Clotet, Edith, Portella, Maria J., Qiu, Jiang, Radua, Joaquim, Bauer, Jochen, Ramos-Quiroga, Josep Antoni, Reddy, Y. C. Janardhan, Reif, Andreas, Roberts, Gloria, Rosa, Pedro, Rubia, Katya, Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Schmaal, Lianne, Baune, Bernhard T, Schulte-Rüther, Martin, Schweren, Lizanne, Seitz, Jochen, Serpa, Mauricio Henriques, Shaw, Philip, Shumskaya, Elena, Silk, Timothy J., Simmons, Alan N., Simulionyte, Egle, Sinha, Rajita, Baur-Streubel, Ramona, Sjoerds, Zsuzsika, Smelror, Runar Elle, Soliva, Joan Carlos, Solowij, Nadia, Souza-Duran, Fabio Luisde, Sponheim, Scott R., Stein, Dan J., Stein, Elliot A., Stevens, Michael, Strike, Lachlan T., Biederman, Joseph, Sudre, Gustavo, Sui, Jing, Tamm, Leanne, Temmingh, Hendrik S., Thoma, Robert J., Tomyshev, Alexander, Tronchin, Giulia, Turner, Jessica, Uhlmann, Anne, Erp, Theo G. M., Blaine, Sara K., Heuvel, Odile A., Meer, Dennis, Eijk, Liza, Vance, Alasdair, Veer, Ilya M., Veltman, Dick J., Venkatasubramanian, Ganesan, Vilarroya, Oscar, Vives-Gilabert, Yolanda, Voineskos, Aristotle N, Boedhoe, Premika, Völzke, Henry, Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wardlaw, Joanna M., Wen, Wei, Westlye, Lars T., Whelan, Christopher D., White, Tonya, Bøen, Erlend, Wiers, Reinout W., Wright, Margaret J., Wittfeld, Katharina, Yang, Tony T., Yasuda, Clarissa L., Yoncheva, Yuliya, Yücel, Murat, Yun, Je-Yeon, Zanetti, Marcus Vinicius, Zhen, Zonglei, Bose, Anushree, Zhu, Xing-xing, Ziegler, Georg C., Zubicaray, Greig I., Zwiers, Marcel, Project, Karolinska Schizophrenia, Glahn, David C., Crivello, Fabrice, Fisher, Simon E., Thompson, Paul M., Bralten, Janita, Farde, Lars, Flyckt, Lena, Engberg, Göran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Piehl, Fredrik, Agartz, Ingrid, Collste, Karin, Brandeis, Daniel, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Sellgren, Carl, Brem, Silvia, Mathias, Samuel R., Brodaty, Henry, Yüksel, Dilara, Brooks, Samantha J., Buitelaar, Jan, Bürger, Christian, Bülow, Robin, Calhoun, Vince, Calvo, Anna, Canales-Rodríguez, Erick Jorge, Cannon, Dara M., Guadalupe, Tulio, Caparelli, Elisabeth C., Castellanos, Francisco X., Cendes, Fernando, Chaim-Avancini, Tiffany Moukbel, Chantiluke, Kaylita, Chen, Qun-lin, Chen, Xiayu, Cheng, Yuqi, Christakou, Anastasia, Clark, Vincent P., Abé, Christoph, Coghill, David, Connolly, Colm G., Conzelmann, Annette, Córdova-Palomera, Aldo, Cousijn, Janna, Crow, Tim, Cubillo, Ana, Dannlowski, Udo, Bruttopilo, Sara Ambrosino, Zeeuw, Patrick, Deary, Ian J., Demeter, Damion V., Di Martino, Adriana, Dickie, Erin W, Dietsche, Bruno, Doan, Nhat Trung, Doherty, Colin P., Doyle, Alysa, Durston, Sarah, Earl, Eric, Akudjedu, Theophilus N., Ehrlich, Stefan, Ekman, Carl Johan, Elvsåshagen, Torbjørn, Epstein, Jeffery N., Fair, Damien A., Faraone, Stephen V., Fernández, Guillén, Flint, Claas, Filho, Geraldo Busatto, Förster, Katharina, Aleman, Andre, Fouche, Jean-Paul, Foxe, John J., Frodl, Thomas, Fuentes-Claramonte, Paola, Fullerton, Janice M., Garavan, Hugh, Santos Garcia, Danielle, Gotlib, Ian H., Goudriaan, Anna E., Grabe, Hans Jörgen, Alhusaini, Saud, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gurholt, Tiril, Haavik, Jan, Hahn, Tim, Hansell, Narelle K., Harris, Mathew A., Hartman, Catharina A., Carmen Valdés Hernández, Maria, Alhusaini, Saud, Del Carmen Valdés Hernández, Maria, Heslenfeld, Dirk, Hester, Robert, Hibar, Derrek Paul, Ho, Beng-Choon, Ho, Tiffany C., Hoekstra, Pieter J., van Holst, Ruth J., Hoogman, Martine, Høvik, Marie F., Allen, Nicholas B., Howells, Fleur M., Hugdahl, Kenneth, Huyser, Chaim, Ingvar, Martin, Ishikawa, Akari, James, Anthony, Jahanshad, Neda, Jernigan, Terry L., Jönsson, Erik G., Kaleda, Vasily, Ames, David, Kelly, Clare, Kerich, Michael, Keshavan, Matcheri S., Khadka, Sabin, Kircher, Tilo, Kohls, Gregor, Konrad, Kerstin, Korucuoglu, Ozlem, Krämer, Bernd, Krug, Axel, Andreassen, Ole A., Kuntsi, Jonna, Kwon, Jun Soo, Lambregts-Rommelse, Nanda, Landén, Mikael, Lázaro, Luisa, Lebedeva, Irina, Lenroot, Rhoshel, Lesch, Klaus-Peter, Li, Qinqin, Lim, Kelvin O., Vasquez, Alejandro Arias, Liu, Jia, Lochner, Christine, London, Edythe D., Lorenzetti, Valentina, Luciano, Michelle, Luijten, Maartje, Lundervold, Astri J., Mackey, Scott, MacMaster, Frank P., Maingault, Sophie, Armstrong, Nicola J., Malpas, Charles B., Malt, Ulrik F., Mataix-Cols, David, Martin-Santos, Rocio, Mayer, Andrew R., McCarthy, Hazel, Medland, Sarah, Metha, Mitul, Mitchell, Philip B., Mueller, Bryon A., Asherson, Phil, Maniega, Susana Muñoz, Mazoyer, Bernard, McDonald, Colm, McLellan, Quinn, McMahon, Katie L., McPhilemy, Genevieve, Momenan, Reza, Morales, Angelica M., Narayanaswamy, Janardhanan C., Moreira, José Carlos Vasques, Bergo, Felipe, Nerland, Stener, Nestor, Liam, Newman, Erik, Nigg, Joel T., Nordvik, Jan Egil, Novotny, Stephanie, Weiss, Eileen Oberwelland, O'Gorman, Ruth L., Oosterlaan, Jaap, Oranje, Bob, Bastin, Mark E., Orr, Catherine, Overs, Bronwyn, Paloyelis, Yannis, Pauli, Paul, Paulus, Martin, Plessen, Kerstin Jessica, von Polier, Georg G., Pomarol-Clotet, Edith, Portella, Maria J., Qiu, Jiang, Batalla, Albert, Radua, Joaquim, Ramos-Quiroga, Josep Antoni, Reddy, Y. C. Janardhan, Reif, Andreas, Roberts, Gloria, Rosa, Pedro, Rubia, Katya, Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Bauer, Jochen, Schmaal, Lianne, Schulte-Rüther, Martin, Schweren, Lizanne, Seitz, Jochen, Serpa, Mauricio Henriques, Shaw, Philip, Shumskaya, Elena, Silk, Timothy J., Simmons, Alan N., Simulionyte, Egle, Baune, Bernhard T., Sinha, Rajita, Sjoerds, Zsuzsika, Smelror, Runar Elle, Soliva, Joan Carlos, Solowij, Nadia, Souza-Duran, Fabio Luisde, Sponheim, Scott R., Stein, Dan J., Stein, Elliot A., Stevens, Michael, Baur-Streubel, Ramona, Strike, Lachlan T., Sudre, Gustavo, Sui, Jing, Tamm, Leanne, Temmingh, Hendrik S., Thoma, Robert J., Tomyshev, Alexander, Tronchin, Giulia, Turner, Jessica, Uhlmann, Anne, Biederman, Joseph, van Erp, Theo G. M., van den Heuvel, Odile A., van der Meer, Dennis, van Eijk, Liza, Vance, Alasdair, Veer, Ilya M., Veltman, Dick J., Venkatasubramanian, Ganesan, Vilarroya, Oscar, Vives-Gilabert, Yolanda, Blaine, Sara K., Voineskos, Aristotle N., Völzke, Henry, Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wardlaw, Joanna M., Wen, Wei, Westlye, Lars T., Whelan, Christopher D., Boedhoe, Premika, White, Tonya, Wiers, Reinout W., Wright, Margaret J., Wittfeld, Katharina, Yang, Tony T., Yasuda, Clarissa L., Yoncheva, Yuliya, Yücel, Murat, Yun, Je-Yeon, Zanetti, Marcus Vinicius, Bøen, Erlend, Zhen, Zonglei, Zhu, Xing-Xing, Ziegler, Georg C., de Zubicaray, Greig I., Zwiers, Marcel, Project, Karolinska Schizophrenia, Glahn, David C., Crivello, Fabrice, Fisher, Simon E., Thompson, Paul M., Bose, Anushree, Francks, Clyde, Farde, Lars, Flyckt, Lena, Engberg, Göran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Piehl, Fredrik, Agartz, Ingrid, Bralten, Janita, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Sellgren, Carl, Brandeis, Daniel, Kong, Xiang-Zhen, Brem, Silvia, Brodaty, Henry, Yüksel, Dilara, Brooks, Samantha J., Buitelaar, Jan, Bürger, Christian, Bülow, Robin, Calhoun, Vince, Calvo, Anna, Canales-Rodríguez, Erick Jorge, Mathias, Samuel R., Cannon, Dara M., Caparelli, Elisabeth C., Castellanos, Francisco X., Cendes, Fernando, Chaim-Avancini, Tiffany Moukbel, Chantiluke, Kaylita, Chen, Qun-Lin, Chen, Xiayu, Cheng, Yuqi, Christakou, Anastasia, Guadalupe, Tulio, Clark, Vincent P., Coghill, David, Connolly, Colm G., Conzelmann, Annette, Córdova-Palomera, Aldo, Cousijn, Janna, Crow, Tim, Cubillo, Ana, Dannlowski, Udo, de Bruttopilo, Sara Ambrosino, Abé, Christoph, de Zeeuw, Patrick, Deary, Ian J., Demeter, Damion V., Di Martino, Adriana, Dickie, Erin W., Dietsche, Bruno, Doan, Nhat Trung, Doherty, Colin P., Doyle, Alysa, Durston, Sarah, Earl, Eric, Ehrlich, Stefan, Ekman, Carl Johan, Elvsåshagen, Torbjørn, Epstein, Jeffery N., Fair, Damien A., Faraone, Stephen V., Fernández, Guillén, Flint, Claas, Filho, Geraldo Busatto, Akudjedu, Theophilus N., Förster, Katharina, Fouche, Jean-Paul, Foxe, John J., Frodl, Thomas, Fuentes-Claramonte, Paola, Fullerton, Janice M., Garavan, Hugh, do Santos Garcia, Danielle, Gotlib, Ian H., Goudriaan, Anna E., Aleman, Andre, Grabe, Hans Jörgen, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gurholt, Tiril, Haavik, Jan, Hahn, Tim, Hansell, Narelle K., Harris, Mathew A., Hartman, Catharina A., Ontwikkelingspsychologie (Psychologie, FMG), Adult Psychiatry, APH - Mental Health, ANS - Compulsivity, Impulsivity & Attention, Child and Adolescent Psychiatry & Psychosocial Care, Child Psychiatry, ANS - Cellular & Molecular Mechanisms, Laboratory Genetic Metabolic Diseases, Paediatrics, General Paediatrics, ARD - Amsterdam Reproduction and Development, Paediatric Pulmonology, Graduate School, and APH - Digital Health
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P‐hacking ,Datasets as Topic ,Publication bias ,0302 clinical medicine ,130 000 Cognitive Neurology & Memory ,Statistics ,team science ,Brain asymmetry ,Multicenter Studies as Topic ,Cervell ,Research Articles ,Cerebral Cortex ,Radiological and Ultrasound Technology ,P-hacking ,05 social sciences ,Brain ,Cerebral cortex ,Middle Aged ,Magnetic Resonance Imaging ,Discoveries in science ,Escorça cerebral ,Neurology ,Biaix de publicació ,Anatomy ,Psychology ,Research Article ,Neuroinformatics ,Adult ,Adolescent ,Neuroimaging ,Descobriments científics ,050105 experimental psychology ,Statistical power ,03 medical and health sciences ,Young Adult ,Magnetic resonance imaging ,Imatges per ressonància magnètica ,multisite collaboration ,Humans ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,ddc:610 ,reproducibility ,Aged ,publication bias ,Reproducibility ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,Perspective (graphical) ,Reproducibility of Results ,Brain Cortical Thickness ,Research data ,Sample size determination ,Dades de recerca ,Neurology (clinical) ,Scale (map) ,Developmental Psychopathology ,030217 neurology & neurosurgery - Abstract
The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such as p‐hacking. Low statistical power in individual studies is also understood to be an important factor. In a recent multisite collaborative study, we mapped brain anatomical left–right asymmetries for regional measures of surface area and cortical thickness, in 99 MRI datasets from around the world, for a total of over 17,000 participants. In the present study, we revisited these hemispheric effects from the perspective of reproducibility. Within each dataset, we considered that an effect had been reproduced when it matched the meta‐analytic effect from the 98 other datasets, in terms of effect direction and significance threshold. In this sense, the results within each dataset were viewed as coming from separate studies in an “ideal publishing environment,” that is, free from selective reporting and p hacking. We found an average reproducibility rate of 63.2% (SD = 22.9%, min = 22.2%, max = 97.0%). As expected, reproducibility was higher for larger effects and in larger datasets. Reproducibility was not obviously related to the age of participants, scanner field strength, FreeSurfer software version, cortical regional measurement reliability, or regional size. These findings constitute an empirical illustration of reproducibility in the absence of publication bias or p hacking, when assessing realistic biological effects in heterogeneous neuroscience data, and given typically‐used sample sizes., Region‐wise effect sizes and reproducibility rates of hemispheric asymmetry effects. In general, effects with higher effect sizes showed higher reproducibility, given the same conditions (e.g., sample size and data heterogeneity).
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- 2022
24. Morphological, cellular, and molecular basis of brain infection in COVID-19 patients
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Crunfli, Fernanda, primary, Carregari, Victor C., additional, Veras, Flavio P., additional, Silva, Lucas S., additional, Nogueira, Mateus Henrique, additional, Antunes, André Saraiva Leão Marcelo, additional, Vendramini, Pedro Henrique, additional, Valença, Aline Gazzola Fragnani, additional, Brandão-Teles, Caroline, additional, Zuccoli, Giuliana da Silva, additional, Reis-de-Oliveira, Guilherme, additional, Silva-Costa, Lícia C., additional, Saia-Cereda, Verônica Monteiro, additional, Smith, Bradley J., additional, Codo, Ana Campos, additional, de Souza, Gabriela F, additional, Muraro, Stéfanie P., additional, Parise, Pierina Lorencini, additional, Toledo-Teixeira, Daniel A., additional, Santos de Castro, Ícaro Maia, additional, Melo, Bruno Marcel, additional, Almeida, Glaucia M., additional, Firmino, Egidi Mayara Silva, additional, Paiva, Isadora Marques, additional, Silva, Bruna Manuella Souza, additional, Guimarães, Rafaela Mano, additional, Mendes, Niele D., additional, Ludwig, Raíssa L., additional, Ruiz, Gabriel P., additional, Knittel, Thiago L., additional, Davanzo, Gustavo G., additional, Gerhardt, Jaqueline Aline, additional, Rodrigues, Patrícia Brito, additional, Forato, Julia, additional, Amorim, Mariene Ribeiro, additional, Brunetti, Natália S., additional, Martini, Matheus Cavalheiro, additional, Benatti, Maíra Nilson, additional, Batah, Sabrina S., additional, Siyuan, Li, additional, João, Rafael B., additional, Aventurato, Ítalo K., additional, Rabelo de Brito, Mariana, additional, Mendes, Maria J., additional, da Costa, Beatriz A., additional, Alvim, Marina K. M., additional, da Silva Júnior, José Roberto, additional, Damião, Lívia L., additional, de Sousa, Iêda Maria P., additional, da Rocha, Elessandra D., additional, Gonçalves, Solange M., additional, Lopes da Silva, Luiz H., additional, Bettini, Vanessa, additional, Campos, Brunno M., additional, Ludwig, Guilherme, additional, Tavares, Lucas Alves, additional, Pontelli, Marjorie Cornejo, additional, Viana, Rosa Maria Mendes, additional, Martins, Ronaldo B., additional, Vieira, Andre Schwambach, additional, Alves-Filho, José Carlos, additional, Arruda, Eurico, additional, Podolsky-Gondim, Guilherme Gozzoli, additional, Santos, Marcelo Volpon, additional, Neder, Luciano, additional, Damasio, André, additional, Rehen, Stevens, additional, Vinolo, Marco Aurélio Ramirez, additional, Munhoz, Carolina Demarchi, additional, Louzada-Junior, Paulo, additional, Oliveira, Renê Donizeti, additional, Cunha, Fernando Q., additional, Nakaya, Helder I., additional, Mauad, Thais, additional, Duarte-Neto, Amaro Nunes, additional, Ferraz da Silva, Luiz Fernando, additional, Dolhnikoff, Marisa, additional, Saldiva, Paulo Hilario Nascimento, additional, Farias, Alessandro S., additional, Cendes, Fernando, additional, Moraes-Vieira, Pedro Manoel M., additional, Fabro, Alexandre T., additional, Sebollela, Adriano, additional, Proença-Modena, José L., additional, Yasuda, Clarissa L., additional, Mori, Marcelo A., additional, Cunha, Thiago M., additional, and Martins-de-Souza, Daniel, additional
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- 2022
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25. Fast, Accurate and Precise Mid-Sagittal Plane Location in 3D MR Images of the Brain
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Bergo, Felipe P. G., Falcão, Alexandre X., Yasuda, Clarissa L., Ruppert, Guilherme C. S., Fred, Ana, editor, Filipe, Joaquim, editor, and Gamboa, Hugo, editor
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- 2009
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26. Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study
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Whelan, Christopher D, Altmann, Andre, Botía, Juan A, Jahanshad, Neda, Hibar, Derrek P, Absil, Julie, Alhusaini, Saud, Alvim, Marina K M, Auvinen, Pia, Bartolini, Emanuele, Bergo, Felipe P G, Bernardes, Tauana, Blackmon, Karen, Braga, Barbara, Caligiuri, Maria Eugenia, Calvo, Anna, Carr, Sarah J, Chen, Jian, Chen, Shuai, Cherubini, Andrea, David, Philippe, Domin, Martin, Foley, Sonya, França, Wendy, Haaker, Gerrit, Isaev, Dmitry, Keller, Simon S, Kotikalapudi, Raviteja, Kowalczyk, Magdalena A, Kuzniecky, Ruben, Langner, Soenke, Lenge, Matteo, Leyden, Kelly M, Liu, Min, Loi, Richard Q, Martin, Pascal, Mascalchi, Mario, Morita, Marcia E, Pariente, Jose C, Rodríguez-Cruces, Raul, Rummel, Christian, Saavalainen, Taavi, Semmelroch, Mira K, Severino, Mariasavina, Thomas, Rhys H, Tondelli, Manuela, Tortora, Domenico, Vaudano, Anna Elisabetta, Vivash, Lucy, von Podewils, Felix, Wagner, Jan, Weber, Bernd, Yao, Yi, Yasuda, Clarissa L, Zhang, Guohao, Bargalló, Nuria, Bender, Benjamin, Bernasconi, Neda, Bernasconi, Andrea, Bernhardt, Boris C, Blümcke, Ingmar, Carlson, Chad, Cavalleri, Gianpiero L, Cendes, Fernando, Concha, Luis, Delanty, Norman, Depondt, Chantal, Devinsky, Orrin, Doherty, Colin P, Focke, Niels K, Gambardella, Antonio, Guerrini, Renzo, Hamandi, Khalid, Jackson, Graeme D, Kälviäinen, Reetta, Kochunov, Peter, Kwan, Patrick, Labate, Angelo, McDonald, Carrie R, Meletti, Stefano, OʼBrien, Terence J, Ourselin, Sebastien, Richardson, Mark P, Striano, Pasquale, Thesen, Thomas, Wiest, Roland, Zhang, Junsong, Vezzani, Annamaria, Ryten, Mina, Thompson, Paul M, and Sisodiya, Sanjay M
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- 2018
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27. Is inpatient ictal video‐electroencephalographic monitoring mandatory in mesial temporal lobe epilepsy with unilateral hippocampal sclerosis? A prospective study
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Alvim, Marina K. M., Morita, Marcia E., Yasuda, Clarissa L., Damasceno, Benito P., Lopes, Tátila M., Coan, Ana Carolina, Ghizoni, Enrico, Tedeschi, Helder, and Cendes, Fernando
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- 2018
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28. Superficial and deep white matter diffusion abnormalities in focal epilepsies
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Urquia‐Osorio, Hebel, primary, Pimentel‐Silva, Luciana R., additional, Rezende, Thiago Junqueira Ribeiro, additional, Almendares‐Bonilla, Eimy, additional, Yasuda, Clarissa L., additional, Concha, Luis, additional, and Cendes, Fernando, additional
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- 2022
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29. Circulating Metabolites as Biomarkers of Disease in Patients with Mesial Temporal Lobe Epilepsy
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Godoi, Alexandre B., primary, do Canto, Amanda M., additional, Donatti, Amanda, additional, Rosa, Douglas C., additional, Bruno, Danielle C. F., additional, Alvim, Marina K., additional, Yasuda, Clarissa L., additional, Martins, Lucas G., additional, Quintero, Melissa, additional, Tasic, Ljubica, additional, Cendes, Fernando, additional, and Lopes-Cendes, Iscia, additional
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- 2022
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30. Brain tissue MR-image segmentation via optimum-path forest clustering
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Cappabianco, Fábio A.M., Falcão, Alexandre X., Yasuda, Clarissa L., and Udupa, Jayaram K.
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- 2012
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31. Benchmarking the proteomic profile of animal models of mesial temporal epilepsy
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Canto, Amanda M., primary, Godoi, Alexandre B., additional, Matos, Alexandre H. B., additional, Geraldis, Jaqueline C., additional, Rogerio, Fabio, additional, Alvim, Marina K. M., additional, Yasuda, Clarissa L., additional, Ghizoni, Enrico, additional, Tedeschi, Helder, additional, Veiga, Diogo F. T., additional, Henning, Barbara, additional, Souza, Welliton, additional, Rocha, Cristiane S., additional, Vieira, André S., additional, Dias, Elayne V., additional, Carvalho, Benilton S., additional, Gilioli, Rovilson, additional, Arul, Albert B., additional, Robinson, Renã A. S., additional, Cendes, Fernando, additional, and Lopes‐Cendes, Iscia, additional
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- 2022
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32. International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke
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Mishra, Nishant K., primary, Engel, Jerome, additional, Liebeskind, David S., additional, Sharma, Vijay K., additional, Hirsch, Lawrence J., additional, Kasner, Scott E, additional, French, Jacqueline A., additional, Devinsky, Orrin, additional, Friedman, Alon, additional, Dawson, Jesse, additional, Quinn, Terence J., additional, Selim, Magdy, additional, de Havenon, Adam, additional, Yasuda, Clarissa L., additional, Cendes, Fernando, additional, Benninger, Felix, additional, Zaveri, Hitten P., additional, Burneo, Jorge G., additional, Srivastava, Padma, additional, Bhushan Singh, Mamta, additional, Bhatia, Rohit, additional, Vishnu, V.Y., additional, Bentes, Carla, additional, Ferro, Jose, additional, Weiss, Shennan, additional, Sivaraju, Adithya, additional, Kim, Jennifer A., additional, Galovic, Marian, additional, Gilmore, Emily J., additional, Pitkänen, Asla, additional, Davis, Kathryn, additional, Sansing, Lauren H., additional, Sheth, Kevin N., additional, Paz, Jeanne T., additional, Singh, Anuradha, additional, Sheth, Sunil, additional, Worrall, Bradford B., additional, Grotta, James C., additional, Casillas-Espinos, Pablo M., additional, Chen, Zhibin, additional, Nicolo, John-Paul, additional, Yan, Bernard, additional, and Kwan, Patrick, additional
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- 2022
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33. Junctional instability in neuroepithelium and network hyperexcitability in a focal cortical dysplasia human model
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Avansini, Simoni H, primary, Puppo, Francesca, additional, Adams, Jason W, additional, Vieira, Andre S, additional, Coan, Ana C, additional, Rogerio, Fabio, additional, Torres, Fabio R, additional, Araújo, Patricia A O R, additional, Martin, Mariana, additional, Montenegro, Maria A, additional, Yasuda, Clarissa L, additional, Tedeschi, Helder, additional, Ghizoni, Enrico, additional, França, Andréa F E C, additional, Alvim, Marina K M, additional, Athié, Maria C, additional, Rocha, Cristiane S, additional, Almeida, Vanessa S, additional, Dias, Elayne V, additional, Delay, Lauriane, additional, Molina, Elsa, additional, Yaksh, Tony L, additional, Cendes, Fernando, additional, Lopes Cendes, Iscia, additional, and Muotri, Alysson R, additional
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- 2021
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34. Structural network alterations in focal and generalized epilepsy follow axes of epilepsy risk gene expression: An ENIGMA study
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Larivière, Sara, primary, Royer, Jessica, additional, Rodríguez-Cruces, Raúl, additional, Caligiuri, Maria Eugenia, additional, Gambardella, Antonio, additional, Concha, Luis, additional, Keller, Simon S., additional, Cendes, Fernando, additional, Yasuda, Clarissa L., additional, Bonilha, Leonardo, additional, Gleichgerrcht, Ezequiel, additional, Focke, Niels K., additional, Domin, Martin, additional, von Podewills, Felix, additional, Langner, Soenke, additional, Rummel, Christian, additional, Wiest, Roland, additional, Martin, Pascal, additional, Kotikalapudi, Raviteja, additional, O’Brien, Terence J., additional, Sinclair, Benjamin, additional, Vivash, Lucy, additional, Desmond, Patricia M., additional, Lui, Elaine, additional, Vaudano, Anna Elisabetta, additional, Meletti, Stefano, additional, Tondelli, Manuela, additional, Alhusaini, Saud, additional, Doherty, Colin P., additional, Cavalleri, Gianpiero L., additional, Delanty, Norman, additional, Kälviäinen, Reetta, additional, Jackson, Graeme D., additional, Kowalczyk, Magdalena, additional, Mascalchi, Mario, additional, Semmelroch, Mira, additional, Thomas, Rhys H., additional, Soltanian-Zadeh, Hamid, additional, Davoodi-Bojd, Esmaeil, additional, Zhang, Junsong, additional, Kreilkamp, Barbara A. K., additional, Lenge, Matteo, additional, Guerrini, Renzo, additional, Hamandi, Khalid, additional, Foley, Sonya, additional, Rüber, Theodor, additional, Weber, Bernd, additional, Depondt, Chantal, additional, Absil, Julie, additional, Carr, Sarah J. A., additional, Abela, Eugenio, additional, Richardson, Mark P., additional, Devinsky, Orrin, additional, Severino, Mariasavina, additional, Striano, Pasquale, additional, Tortora, Domenico, additional, Hatton, Sean N., additional, Vos, Sjoerd B., additional, Caciagli, Lorenzo, additional, Duncan, John S., additional, Whelan, Christopher D., additional, Thompson, Paul M., additional, Sisodiya, Sanjay M., additional, Bernasconi, Andrea, additional, Labate, Angelo, additional, McDonald, Carrie R., additional, Bernasconi, Neda, additional, and Bernhardt, Boris C., additional
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- 2021
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35. Voxel-based morphometry and intellectual assessment in patients with congenital bilateral perisylvian syndrome
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Yasuda, Clarissa L., Guimarães, Catarina A., Guerreiro, Marilisa M., Boscariol, Mirela, Oliveira, Ecila P. M., Teixeira, Karine C., Costa, André L. F., Beltramini, Guilherme C., and Cendes, Fernando
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- 2014
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36. In response: Brain atrophy in seizure-free temporal lobe epilepsy: Implications for predicting pharmacoresistance
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Alvim, Marina K. M., Coan, Ana C., Yasuda, Clarissa L., Morita, Marcia E., and Cendes, Fernando
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- 2016
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37. Progression of gray matter atrophy in seizure-free patients with temporal lobe epilepsy
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Alvim, Marina K. M., Coan, Ana C., Campos, Brunno M., Yasuda, Clarissa L., Oliveira, Mariana C., Morita, Marcia E., and Cendes, Fernando
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- 2016
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38. Multidimensional Approach Assessing the Role of Interleukin 1 Beta in Mesial Temporal Lobe Epilepsy
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Santos, Renato O., primary, Secolin, Rodrigo, additional, Barbalho, Patrícia G., additional, Silva-Alves, Mariana S., additional, Alvim, Marina K. M., additional, Yasuda, Clarissa L., additional, Rogerio, Fábio, additional, Velasco, Tonicarlo R., additional, Sakamoto, Americo C., additional, Teixeira, Antonio L., additional, Cendes, Fernando, additional, Maurer-Morelli, Claudia V., additional, and Lopes-Cendes, Iscia, additional
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- 2021
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39. Improving the prediction of epilepsy surgery outcomes using basic scalp EEG findings
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Fitzgerald, Zachary, primary, Morita‐Sherman, Marcia, additional, Hogue, Olivia, additional, Joseph, Boney, additional, Alvim, Marina K. M., additional, Yasuda, Clarissa L., additional, Vegh, Deborah, additional, Nair, Dileep, additional, Burgess, Richard, additional, Bingaman, William, additional, Najm, Imad, additional, Kattan, Michael W., additional, Blumcke, Ingmar, additional, Worrell, Gregory, additional, Brinkmann, Benjamin H., additional, Cendes, Fernando, additional, and Jehi, Lara, additional
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- 2021
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40. Inflammatory and neurotrophic factor plasma levels are related to epilepsy independently of etiology
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Alvim, Marina K. M., primary, Morita‐Sherman, Marcia E., additional, Yasuda, Clarissa L., additional, Rocha, Natália P., additional, Vieira, Érica L., additional, Pimentel‐Silva, Luciana R., additional, Henrique Nogueira, Mateus, additional, Barbosa, Renata, additional, Watanabe, Nancy, additional, Coan, Ana Carolina, additional, Lopes‐Cendes, Iscia, additional, Teixeira, Antonio L., additional, and Cendes, Fernando, additional
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- 2021
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41. Association Analysis of Candidate Variants in Admixed Brazilian Patients With Genetic Generalized Epilepsies
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Kaibara, Felipe S., primary, de Araujo, Tânia K., additional, Araujo, Patricia A. O. R. A., additional, Alvim, Marina K. M., additional, Yasuda, Clarissa L., additional, Cendes, Fernando, additional, Lopes-Cendes, Iscia, additional, and Secolin, Rodrigo, additional
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- 2021
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42. Modified Anterior Temporal Lobectomy: Anatomical Landmarks and Operative Technique
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Ghizoni, Enrico, Almeida, J. P., Joaquim, Andrei F., Yasuda, Clarissa L., de Campos, Brunno M., Tedeschi, Helder, and Cendes, Fernando
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- 2015
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43. Neuroanatomical Correlates of Depression in Friedreich’s Ataxia: a Voxel-Based Morphometry Study
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da Silva, Cynthia B., Yasuda, Clarissa L., D’Abreu, Anelyssa, Cendes, Fernando, Lopes-Cendes, Iscia, and França, Jr, Marcondes C.
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- 2013
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44. Magnetic resonance imaging findings and clinical characteristics in mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy in a predominantly adult cohort
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Mendes Coelho, Vanessa C., primary, Morita‐Sherman, Marcia, additional, Yasuda, Clarissa L., additional, Alvim, Marina M. K., additional, Amorim, Barbara Juarez, additional, Tedeschi, Helder, additional, Ghizoni, Enrico, additional, Rogerio, Fabio, additional, and Cendes, Fernando, additional
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- 2021
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45. Memory impairment is not necessarily related to seizure frequency in mesial temporal lobe epilepsy with hippocampal sclerosis
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Pacagnella, Denise, Lopes, Tatila M., Morita, Marcia E., Yasuda, Clarissa L., Cappabianco, Fabio A. M., Bergo, Felipe, Balthazar, Marcio L. F., Coan, Ana C., and Cendes, Fernando
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- 2014
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46. Distinct functional and structural MRI abnormalities in mesial temporal lobe epilepsy with and without hippocampal sclerosis
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Coan, Ana C., Campos, Brunno M., Beltramini, Guilherme C., Yasuda, Clarissa L., Covolan, Roberto J. M., and Cendes, Fernando
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- 2014
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47. Quantifying the pattern of optic tract degeneration in human hemianopia
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Millington, Rebecca S, Yasuda, Clarissa L, Jindahra, Panitha, Jenkinson, Mark, Barbur, John L, Kennard, Christopher, Cendes, Fernando, Plant, Gordon T, and Bridge, Holly
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- 2014
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48. A combined voxel-based morphometry and 1H-MRS study in patients with Friedreich’s ataxia
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França, Jr, Marcondes C., D’Abreu, Anelyssa, Yasuda, Clarissa L., Bonadia, Luciana Cardoso, Santos da Silva, Marilza, Nucci, Anamarli, Lopes-Cendes, Iscia, and Cendes, Fernando
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- 2009
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49. Transsylvian amygdalohippocampectomy for mesial temporal lobe epilepsy: Comparison of three different approaches
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de Souza, João P. S. A. S., primary, Pimentel‐Silva, Luciana R., additional, Ayub, Gabriel, additional, Nogueira, Mateus H., additional, Zanao, Tamires, additional, Yasuda, Clarissa L., additional, Campos, Brunno M., additional, Rogerio, Fabio, additional, Tedeschi, Helder, additional, Cendes, Fernando, additional, and Ghizoni, Enrico, additional
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- 2021
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50. Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
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Hofer, Edith, Roshchupkin, Gennady V, Bernard, Manon, Grasby, Katrina L, Jahanshad, Neda, Painter, Jodie N, Colodro-Conde, Lucía, Bralten, Janita, Hibar, Derrek P, Lind, Penelope A, Pizzagalli, Fabrizio, Ching, Christopher R K, McMahon, Mary Agnes B, Bis, Joshua C, Shatokhina, Natalia, Zsembik, Leo C P, Agartz, Ingrid, Alhusaini, Saud, Almeida, Marcio A A, Alnæs, Dag, Amlien, Inge K, Andersson, Micael, Ard, Tyler, Armstrong, Nicola J, Gillespie, Nathan A, Ashley-Koch, Allison, Brouwer, Rachel M, Buimer, Elizabeth E L, Bülow, Robin, Bürger, Christian, Cannon, Dara M, Chakravarty, Mallar, Chen, Qiang, Cheung, Joshua W, Luciano, Michelle, Couvy-Duchesne, Baptiste, Dale, Anders M, Dalvie, Shareefa, de Araujo, Tânia K, de Zubicaray, Greig I, de Zwarte, Sonja M C, den Braber, Anouk, Doan, Nhat Trung, Dohm, Katharina, Ehrlich, Stefan, Mishra, Aniket, Engelbrecht, Hannah-Ruth, Erk, Susanne, Fan, Chun Chieh, Fedko, Iryna O, Foley, Sonya F, Ford, Judith M, Fukunaga, Masaki, Garrett, Melanie E, Ge, Tian, Giddaluru, Sudheer, Scholz, Markus, Goldman, Aaron L, Groenewold, Nynke A, Grotegerd, Dominik, Gurholt, Tiril P, Gutman, Boris A, Hansell, Narelle K, Harris, Mathew A, Harrison, Marc B, Haswell, Courtney C, Hauser, Michael, Teumer, Alexander, Herms, Stefan, Heslenfeld, Dirk J, Ho, New Fei, Hoehn, David, Hoffmann, Per, Holleran, Laurena, Hoogman, Martine, Hottenga, Jouke-Jan, Ikeda, Masashi, Janowitz, Deborah, Xia, Rui, Jansen, Iris E, Jia, Tianye, Jockwitz, Christiane, Kanai, Ryota, Karama, Sherif, Kasperaviciute, Dalia, Kaufmann, Tobias, Kelly, Sinead, Kikuchi, Masataka, Klein, Marieke, Jian, Xueqiu, Knapp, Michael, Knodt, Annchen R, Krämer, Bernd, Lam, Max, Lancaster, Thomas M, Lee, Phil H, Lett, Tristram A, Lewis, Lindsay B, Lopes-Cendes, Iscia, Mosley, Thomas H, Macciardi, Fabio, Marquand, Andre F, Mathias, Samuel R, Melzer, Tracy R, Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Moreira, Jose C V, Mühleisen, Thomas W, Müller-Myhsok, Bertram, Najt, Pablo, Adams, Hieab H H, Saba, Yasaman, Nakahara, Soichiro, Nho, Kwangsik, Olde Loohuis, Loes M, Orfanos, Dimitri Papadopoulos, Pearson, John F, Pitcher, Toni L, Pütz, Benno, Ragothaman, Anjanibhargavi, Rashid, Faisal M, Redlich, Ronny, Pirpamer, Lukas, Reinbold, Céline S, Repple, Jonathan, Richard, Geneviève, Riedel, Brandalyn C, Risacher, Shannon L, Rocha, Cristiane S, Mota, Nina Roth, Salminen, Lauren, Saremi, Arvin, Saykin, Andrew J, Seiler, Stephan, Schlag, Fenja, Schmaal, Lianne, Schofield, Peter R, Secolin, Rodrigo, Shapland, Chin Yang, Shen, Li, Shin, Jean, Shumskaya, Elena, Sønderby, Ida E, Sprooten, Emma, Becker, James T, Strike, Lachlan T, Tansey, Katherine E, Thalamuthu, Anbupalam, Thomopoulos, Sophia I, Tordesillas-Gutiérrez, Diana, Turner, Jessica A, Uhlmann, Anne, Vallerga, Costanza Ludovica, van der Meer, Dennis, Carmichael, Owen, van Donkelaar, Marjolein M J, van Eijk, Liza, van Erp, Theo G M, van Haren, Neeltje E M, van Rooij, Daan, van Tol, Marie-José, Veldink, Jan H, Verhoef, Ellen, Walton, Esther, Wang, Mingyuan, Rotter, Jerome I, Wang, Yunpeng, Wardlaw, Joanna M, Wen, Wei, Westlye, Lars T, Whelan, Christopher D, Witt, Stephanie H, Wittfeld, Katharina, Wolf, Christiane, Wolfers, Thomas, Yasuda, Clarissa L, Psaty, Bruce M, Zaremba, Dario, Zhang, Zuo, Zhu, Alyssa H, Zwiers, Marcel P, Artiges, Eric, Assareh, Amelia A, Ayesa-Arriola, Rosa, Belger, Aysenil, Brandt, Christine L, Brown, Gregory G, Lopez, Oscar L, Cichon, Sven, Curran, Joanne E, Davies, Gareth E, Degenhardt, Franziska, Dietsche, Bruno, Djurovic, Srdjan, Doherty, Colin P, Espiritu, Ryan, Garijo, Daniel, Gil, Yolanda, Amin, Najaf, Gowland, Penny A, Green, Robert C, Häusler, Alexander N, Heindel, Walter, Ho, Beng-Choon, Hoffmann, Wolfgang U, Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Jack, Clifford R, van der Lee, Sven J, Jang, MiHyun, Jansen, Andreas, Kolskår, Knut, Koops, Sanne, Krug, Axel, Lim, Kelvin O, Luykx, Jurjen J, Mathalon, Daniel H, Mather, Karen A, Mattay, Venkata S, Knol, Maria J, Yang, Qiong, Matthews, Sarah, Son, Jaqueline Mayoral Van, McEwen, Sarah C, Melle, Ingrid, Morris, Derek W, Mueller, Bryon A, Nauck, Matthias, Nordvik, Jan E, Nöthen, Markus M, O'Leary, Daniel S, Himali, Jayandra J, Opel, Nils, Martinot, Marie -Laure Paillère, Pike, G Bruce, Preda, Adrian, Quinlan, Erin B, Ratnakar, Varun, Reppermund, Simone, Steen, Vidar M, Torres, Fábio R, Veltman, Dick J, Maillard, Pauline, Voyvodic, James T, Whelan, Robert, White, Tonya, Yamamori, Hidenaga, Alvim, Marina K M, Ames, David, Anderson, Tim J, Andreassen, Ole A, Arias-Vasquez, Alejandro, Bastin, Mark E, Beiser, Alexa S, Baune, Bernhard T, Blangero, John, Boomsma, Dorret I, Brodaty, Henry, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Bustillo, Juan R, Cahn, Wiepke, Calhoun, Vince, DeCarli, Charles, Caseras, Xavier, Caspers, Svenja, Cavalleri, Gianpiero L, Cendes, Fernando, Corvin, Aiden, Crespo-Facorro, Benedicto, Dalrymple-Alford, John C, Dannlowski, Udo, de Geus, Eco J C, Deary, Ian J, Delanty, Norman, Depondt, Chantal, Desrivières, Sylvane, Donohoe, Gary, Espeseth, Thomas, Fernández, Guillén, Fisher, Simon E, Flor, Herta, Forstner, Andreas J, Francks, Clyde, Lewis, Lindsay, Franke, Barbara, Glahn, David C, Gollub, Randy L, Grabe, Hans J, Gruber, Oliver, Håberg, Asta K, Hariri, Ahmad R, Hartman, Catharina A, Hashimoto, Ryota, Heinz, Andreas, Harris, Mat, Hillegers, Manon H J, Hoekstra, Pieter J, Holmes, Avram J, Hong, L Elliot, Hopkins, William D, Hulshoff Pol, Hilleke E, Jernigan, Terry L, Jönsson, Erik G, Kahn, René S, Kennedy, Martin A, Kircher, Tilo T J, Kochunov, Peter, Kwok, John B J, Hellard, Stephanie Le, Martin, Nicholas G, Martinot, Jean -Luc, McDonald, Colm, McMahon, Katie L, Meyer-Lindenberg, Andreas, Morey, Rajendra A, Nyberg, Lars, Oosterlaan, Jaap, Ophoff, Roel A, Paus, Tomáš, Pausova, Zdenka, Penninx, Brenda W J H, Polderman, Tinca J C, Posthuma, Danielle, Rietschel, Marcella, Roffman, Joshua L, Lin, Honghuang, Veronica Witte, A., Rowland, Laura M, Sachdev, Perminder S, Sämann, Philipp G, Schumann, Gunter, Sim, Kang, Sisodiya, Sanjay M, Smoller, Jordan W, Sommer, Iris E, Pourcain, Beate St, Stein, Dan J, Beyer, Frauke, Toga, Arthur W, Trollor, Julian N, Van der Wee, Nic J A, van 't Ent, Dennis, Völzke, Henry, Walter, Henrik, Weber, Bernd, Weinberger, Daniel R, Wright, Margaret J, Zhou, Juan, Loeffler, Markus, Stein, Jason L, Thompson, Paul M, Medland, Sarah E, Kwok, John B, Trollor, Julian, Li, Shuo, Jiang, Jiyang, Vernooij, Meike W, Hofman, Albert, Uitterlinden, André G, Niessen, Wiro J, Völker, Uwe, Zare, Habil, Bruce Pike, G., Maingault, Sophie, Crivello, Fabrice, Tzourio, Christophe, Amouyel, Philippe, Mazoyer, Bernard, Neale, Michael C, Franz, Carol E, Lyons, Michael J, Ahmad, Shahzad, Panizzon, Matthew S, Logue, Mark, consortium, ENIGMA, Kremen, William S, Villringer, Arno, Satizabal, Claudia L, van Duijn, Cornelia M, Grabe, Hans, Longstreth, William T, Fornage, Myriam, Paus, Tomas, Debette, Stephanie, Ikram, M Arfan, Schmidt, Helena, Schmidt, Reinhold, Seshadri, Sudha, University of Graz, Medical University Graz, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Boston University School of Medicine (BUSM), Boston University [Boston] (BU), School of Public Health [Boston], University of Texas Health Science Center, The University of Texas Health Science Center at Houston (UTHealth), The University of Texas at San Antonio (UTSA), Murdoch University, The Hospital for sick children [Toronto] (SickKids), University of Washington [Seattle], Virginia Commonwealth University (VCU), QIMR Berghofer Medical Research Institute, University of Edinburgh, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universität Leipzig [Leipzig], Universität Greifswald - University of Greifswald, University of Mississippi Medical Center (UMMC), University of California [Davis] (UC Davis), University of California, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), Pennington Biomedical Research Center, Louisiana State University (LSU), Los Angeles Biomedical Research Institute (LA BioMed), McGill University = Université McGill [Montréal, Canada], Max Planck Institute for Human Cognitive and Brain Sciences [Leipzig] (IMPNSC), Max-Planck-Gesellschaft, University of New South Wales [Sydney] (UNSW), Neuroscience Research Australia (NeuRA), The University of Sydney, University of Queensland [Brisbane], The Royal Melbourne Hospital, University of Melbourne, Harvard T.H. Chan School of Public Health, Delft University of Technology (TU Delft), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), University of Toronto, University of Calgary, Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), CHU Bordeaux [Bordeaux], Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Réseau International des Instituts Pasteur (RIIP), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University of California [San Diego] (UC San Diego), University of Oslo (UiO), Oslo University Hospital [Oslo], VA Boston Healthcare System, University of Southern California (USC), Radboud University Medical Center [Nijmegen], Radboud university [Nijmegen], Janssen Research & Development, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Prince of Wales Hospital, University Hospital Leipzig, University of Oxford [Oxford], Holland Bloorview Kids Rehabilitation Hospital [Toronto, ON, Canada], Epidemiology, Medical Informatics, Radiology & Nuclear Medicine, Neurology, Complex Trait Genetics, Biological Psychology, Cognitive Psychology, IBBA, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, APH - Mental Health, APH - Methodology, Clinical Neuropsychology, Clinical Developmental Psychology, Amsterdam Neuroscience - Complex Trait Genetics, Movement Disorder (MD), Clinical Cognitive Neuropsychiatry Research Program (CCNP), General Paediatrics, ARD - Amsterdam Reproduction and Development, Karl-Franzens-Universität Graz, Universität Leipzig, University of California (UC), Radboud University [Nijmegen], University of Oxford, Psychiatry, Anatomy and neurosciences, Pediatric surgery, Human genetics, APH - Digital Health, and Karl-Franzens-Universität [Graz, Autriche]
- Subjects
0301 basic medicine ,Male ,Genetics of the nervous system ,Aging ,General Physics and Astronomy ,Genome-wide association study ,Disease ,VARIANTS ,genetics [Mental Disorders] ,Genome-wide association studies ,0302 clinical medicine ,Cognition ,PARKINSONS-DISEASE ,SCHIZOPHRENIA ,80 and over ,2.1 Biological and endogenous factors ,Aetiology ,lcsh:Science ,Aged, 80 and over ,education.field_of_study ,Multidisciplinary ,ENIGMA consortium ,Mental Disorders ,Brain ,Neurodegenerative Diseases ,Genomics ,Single Nucleotide ,Middle Aged ,Biobank ,ALZHEIMERS-DISEASE ,Phenotype ,VINTAGE ,Neurology ,Chromosome Structures ,Schizophrenia ,genetics [Aging] ,Neurological ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Female ,ddc:500 ,Biotechnology ,Adult ,Science ,geentics of the nervous system ,1.1 Normal biological development and functioning ,Population ,SURFACE-AREA ,ORGANIZATION ,Biology ,Polymorphism, Single Nucleotide ,General Biochemistry, Genetics and Molecular Biology ,Article ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Underpinning research ,THICKNESS ,medicine ,Genetics ,Humans ,Polymorphism ,education ,HEALTHY ,METAANALYSIS ,Aged ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] ,Genetic heterogeneity ,neurology ,Human Genome ,Neurosciences ,General Chemistry ,Heritability ,medicine.disease ,Brain Disorders ,INDIVIDUALS ,030104 developmental biology ,[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics ,Evolutionary biology ,genetics [Neurodegenerative Diseases] ,VOLUME ,genome-wide association studies ,lcsh:Q ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging., Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.
- Published
- 2020
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