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14 results on '"Yasuda, Aiko"'

6. Commensal Microbiota Contributes to Chronic Endocarditis in TAX1BP1 Deficient Mice

Author

Nakano, Satoko, primary, Ikebe, Emi, additional, Tsukamoto, Yoshiyuki, additional, Wang, Yan, additional, Matsumoto, Takashi, additional, Mitsui, Takahiro, additional, Yahiro, Takaaki, additional, Inoue, Kunimitsu, additional, Kawazato, Hiroaki, additional, Yasuda, Aiko, additional, Ito, Kanako, additional, Yokoyama, Shigeo, additional, Takahashi, Naohiko, additional, Hori, Mitsuo, additional, Shimada, Tatsuo, additional, Moriyama, Masatsugu, additional, Kubota, Toshiaki, additional, Ono, Katsushige, additional, Fujibuchi, Wataru, additional, Jeang, Kuan-Teh, additional, Iha, Hidekatsu, additional, and Nishizono, Akira, additional

Published
2013
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10. Effects of Asian Sand Dust, Arizona Sand Dust, Amorphous Silica and Aluminum Oxide on Allergic Inflammation in the Murine Lung

Author

Ichinose, Takamich, primary, Yoshida, Seiichi, additional, Sadakane, Kaori, additional, Takano, Hrohisa, additional, Yanagisawa, Rie, additional, Inoue, Kenichi, additional, Nishikawa, Masataka, additional, Mori, Ikuko, additional, Kawazato, Hiroaki, additional, Yasuda, Aiko, additional, and Shibamoto, Takayuki, additional

Published
2008
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14. Commensal Microbiota Contributes to Chronic Endocarditis in TAX1BP1 Deficient Mice.

Author

Nakano, Satoko, Ikebe, Emi, Tsukamoto, Yoshiyuki, Wang, Yan, Matsumoto, Takashi, Mitsui, Takahiro, Yahiro, Takaaki, Inoue, Kunimitsu, Kawazato, Hiroaki, Yasuda, Aiko, Ito, Kanako, Yokoyama, Shigeo, Takahashi, Naohiko, Hori, Mitsuo, Shimada, Tatsuo, Moriyama, Masatsugu, Kubota, Toshiaki, Ono, Katsushige, Fujibuchi, Wataru, and Jeang, Kuan-Teh

Subjects
CARRIER proteins, NF-kappa B, TREATMENT of endocarditis, LABORATORY mice, UBIQUITINATION, GENETIC engineering, SKIN inflammation, GENETIC transcription
Abstract

Tax1-binding protein 1 (Tax1bp1) negatively regulates NF-κB by editing the ubiquitylation of target molecules by its catalytic partner A20. Genetically engineered TAX1BP1-deficient (KO) mice develop age-dependent inflammatory constitutions in multiple organs manifested as valvulitis or dermatitis and succumb to premature death. Laser capture dissection and gene expression microarray analysis on the mitral valves of TAX1BP1-KO mice (8 and 16 week old) revealed 588 gene transcription alterations from the wild type. SAA3 (serum amyloid A3), CHI3L1, HP, IL1B and SPP1/OPN were induced 1,180-, 361-, 187-, 122- and 101-fold respectively. WIF1 (Wnt inhibitory factor 1) exhibited 11-fold reduction. Intense Saa3 staining and significant I-κBα reduction were reconfirmed and massive infiltration of inflammatory lymphocytes and edema formation were seen in the area. Antibiotics-induced ‘germ free’ status or the additional MyD88 deficiency significantly ameliorated TAX1BP1-KO mice's inflammatory lesions. These pathological conditions, as we named ‘pseudo-infective endocarditis’ were boosted by the commensal microbiota who are usually harmless by their nature. This experimental outcome raises a novel mechanistic linkage between endothelial inflammation caused by the ubiquitin remodeling immune regulators and fatal cardiac dysfunction. [ABSTRACT FROM AUTHOR]

Published
2013
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