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OBJECTIVE: To evaluate the clinical effectiveness of treatment with customized compared to noncustomized fixed orthodontic appliances. METHOD: A comprehensive search was performed using 13 databases until February 20, 2024. Study eligibility criteria were based on studies that compared orthodontic treatment with customized fixed appliances (labial or lingual) with noncustomized appliances. All ages and types of malocclusions were included. RESULTS: The search identified 95 studies, of which only four fulfilled the inclusion criteria. Three studies compared labial customized brackets with self-ligating brackets, while one study compared lingual customized brackets with labial conventional brackets. There were no significant differences between these systems for treatment duration, outcome, number of appointments, analgesic consumption, patient satisfaction, and the archwire bends requirement. On the other hand, treatment planning was longer and the finishing and detailing phase was shorter in the customized appliances. There was a greater tendency for mandibular incisor proclination and bracket repositioning in the noncustomized appliances group and a greater number of bracket failures, complaints, and requirements for archwire changes in the customized appliances. Qualitative synthesis was applied due to heterogeneity in investigating the difference between the two appliance systems. CONCLUSION: Based on the current limited evidence, the clinical effectiveness of customized and noncustomized orthodontic appliances was similar for the majority of clinical outcomes. Further high-quality clinical studies are required to confirm this finding. CLINICAL RELEVANCE: Proper treatment planning and clinical management are the key factors for adequate outcomes apart from the type of appliance used. [ABSTRACT FROM AUTHOR]

Graphene is an extraordinary material with unique mechanical, chemical, and thermal properties. Additionally, it boasts high surface area and antimicrobial properties, making it an attractive option for researchers exploring innovative materials for biomedical applications. Although there have been various studies on graphene applications in different biomedical fields, limited reviews have been conducted on its use in dentistry, and no reviews have focused on its application in the orthodontic field. This review aims to present a comprehensive overview of graphene-based materials, with an emphasis on their antibacterial mechanisms and the factors that influence these properties. Additionally, the review summarizes the dental applications of graphene, spotlighting the studies of its orthodontic application as they can be used to enhance the antibacterial and mechanical properties of orthodontic materials such as adhesives, archwires, and splints. Also, they can be utilized to enhance bone remodeling during orthodontic tooth movement. An electronic search was carried out in Scopus, PubMed, Science Direct, and Wiley Online Library digital database platforms using graphene and orthodontics as keywords. The search was restricted to English language publications without a time limit. This review highlights the need for further laboratory and clinical research using graphene-based materials to improve the properties of orthodontic materials to make them available for clinical use. [ABSTRACT FROM AUTHOR]

The current article aims to review the previous studies that measure the orthodontic bracket slot dimensions and geometry. Searches in different databases, including PubMed Central, Science Direct, Wiley Online Library, the Cochrane Library, Textbooks, Google Scholar, and Research Gate, in addition to a manual search, were performed about the methods of assessing orthodontic bracket slot dimension up to March 2023. The irrelevant and duplicate studies were eliminated, leaving 35 studies for this narrative review. The findings indicate that the slots are oversized with diverging walls in most studies. Manufacturers must respect the standards during manufacturing brackets and adhere to the actual dimensions and tolerance values [ABSTRACT FROM AUTHOR]

This article provides an overview of the various methods for measuring distal canine movement and rotation during retraction. Various databases, including PubMed Central, Science Direct, Wiley Online Library, the Cochrane Library, Textbooks, Google Scholar, and Research Gate, and a manual search up until September 2022, were used to search for various methods of measuring distal canine movement and rotation during retraction. After excluding the duplicate articles, the papers explaining these techniques were included. Four significant techniques were identified. The digital method with 3D superimposition is the safest, most accurate, and most accessible of the methods reviewed. [ABSTRACT FROM AUTHOR]

Background White spot lesions (WSLs) are the most common complications of fixed appliance orthodontic treatment. Objectives To evaluate the effectiveness of calcium fluoride nanoparticles-containing orthodontic primer (nCaF2-primer) in preventing the incidence of WSLs during orthodontic treatment. Trial design Single-centre, double-blinded, split-mouth, randomized clinical trial. Methods The sample involved 31 orthodontic patients (≥12 years). Participants were recruited using a simple nonstratified randomization. Data collection, measurements, and analysis were performed blindly. Outcome measures included comparing the effect of nCaF2-primer with control primer (Transbond) regarding the degree of demineralization (DIAGNOdent pen), Streptococcus mutans (S. mutans) bacterial counting [real-time polymerase chain reaction device (PCR)], and WSLs incidence (pre- and post-operative photographs). The measurements were performed before bonding, 1, 3, and 6 months after bonding and after appliance removal. A two-way repeated measure analysis of variance test (for DIAGNOdent pen scores), and Wilcoxon signed-rank test (for the difference between bacterial counting and WSLs incidence) were used (P < 0.05). Results Thirty-one patients were recruited and randomized (mean age 17.9 ± 2.45 years). For the primary outcome (DIAGNOdent pen scores) and secondary outcome of S. mutans counting: 31 patients (310 teeth for each group) were included in scoring at T1 and T3, and 30 patients (300 teeth) were included at T6. While for the photographic scores, 26 patients were included after bracket bonding. The demineralization scores showed significant differences at all-time intervals within the 6 months after bracket bonding which was more noticeable after the first month. There was a significant difference in bacterial count between the two primer groups at the T1 only. Regarding photographic scores, there were no significant differences in the WSLs incidence between the two primers groups after brackets removal. No harm was detected during treatment, except the usual pain/gingival irritation. Conclusions nCaF2-primer effectively decreased demineralization scores within the 6 months after bracket bonding. Moreover, it significantly reduced S. mutans colonization after the first month. However, the tested primer did not have an extra advantage in preventing WSLs development at the clinical level after appliance removal. Trial registration The trial was registered with ClinicalTrials.gov on 8 May 2021 (registration number: NCT04994314). [ABSTRACT FROM AUTHOR]

Background Root resorption can be considered the most unfortunate complication of orthodontic treatment. Objective To evaluate the available evidence regarding orthodontically induced inflammatory root resorption (OIIRR). Search methods A comprehensive literature search was conducted for the systematic reviews investigating OIIRR published up to 24 May 2020. This was accomplished using electronic databases: MEDLINE via OVID, EMBASE, AMED (Allied and Complementary Medicine Database), PubMed, and Web of Science. Any ongoing systematic reviews were searched using Prospero and a grey literature search was undertaken using Google Scholar and OpenGrey (www.opengrey.eu/). No language restriction was applied. Selection criteria Only studies investigating OIIRR were included. Data collection and analysis Screening, quality assessment [using the AMSTAR 2 tool (A Measurement Tool to Assess Systematic Reviews)], and data extraction were performed by two authors independently. Information was categorized and narratively synthesized for the key findings from moderate and high-quality reviews. Results A total of 2033 potentially eligible studies were identified. After excluding the non-relevant studies, 28 systematic reviews were included. Of which, 20 systematic reviews (71.5%) were of moderate and high-quality level of evidence. The incidence and severity of OIIRR increase with the fixed appliance, especially with heavy force, intrusion, torqueing movements, increased treatment duration, and treatment with extractions or with long apical displacement (particularly for maxillary incisors). There was insufficient evidence regarding most other treatment- and patient-related factors on OIIRR. Following all precautionary measures, pausing treatment and regular monitoring benefits patients with OIIRR. Conclusions and implications There is a limited number of high-quality studies in terms of OIIRR. The influence of fixed appliance on root resorption was noted; however, the cause and effect relationship between OIIRR and orthodontic biomechanics has not been confirmed. Avoiding heavy, continuous forces and a greater amount of apical displacement over a long duration of treatment is recommended. Precautionary measures should be carefully considered when treating patients with a high risk of OIIRR. Registration CRD42020166629. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the accuracy and reliability of OneCeph smartphone application for cephalometric analysis in comparison with AutoCAD computer software. Design: A Cross-sectional study. Materials and Methods: Pretreatment digital lateral cephalograms of 50 orthodontic patients (25 males, 25 females) were analyzed with OneCeph application and AutoCAD software (as a standard measure). Fifteen landmarks were marked on each cephalogram and 10 measurements indicating skeletal, dental, and soft tissue parameters from Steiner's analysis were selected and measured (five angular and five linear measurements). A paired t-test was used to assess systematic bias. While Intraclass correlation (ICC) and Bland-Altman plot with linear regression analysis were used to assess the agreement between the two methods. Results: There was an excellent reproducibility for the measurements with OneCeph application (ICC: 0.950-0.999) and AutoCAD software (ICC: 0.973-0.998). Paired t-test did not show statistically significant differences, except for the SNA and SN-MP angles (P < 0.05), but these were of no clinical importance. The ICC test revealed excellent agreements for all the measurements between the OneCeph and AutoCAD, with the values ranged between 0.974 and 0.994. The Bland-Altman plot showed that the size of error was within the acceptable range and the linear regression analysis revealed no proportional bias between the two methods except the upper and lower lip measurements. Conclusions: OneCeph smartphone application can be used with adequate precision and reliability for cephalometric analysis as that with AutoCAD software. [ABSTRACT FROM AUTHOR]

Background: The potential of an improved understanding to prevent and treat a complex oral condition such as root caries is important, given its correlation with multiple factors and the uncertainty surrounding the approach/material of choice. Deeper insights into risk factors may improve the quality of treatment and reduce the formation of root surface caries. Aim: The present work aims to gain knowledge about dentists' opinions and experiences on assessing the risk factor related to the development of root caries and to help identify any overlooked factors that may contribute to less efficacious clinical outcomes. Methodology: A questionnaire related to root surface caries was distributed among practicing dentists in nine different countries, namely the United Kingdom, Libya, Jordan, Saudi Arabia, Egypt, Brazil, India, Malaysia, and Iraq. Questionnaire responses were analyzed, and the results were compared among the groups. Results: Dentists around the world ranked the oral hygiene status of patients as the most important factor in the development of root surface caries. Patients with poor oral hygiene, active periodontal disease, reduced salivary flow, and gingival recession are perceived to have a higher risk of developing new root surface caries. There is a greater focus on prevention in the UK and greater levels of untreated dental disease in other countries, especially those recovering from civil wars. Conclusion: This work identified some overlooked factors that may have contributed to the less efficacious clinical outcomes reported in the literature. It is hoped that this deep dive into risk factors coupled with the findings presented in Part I of this study will be used as a basis for a more comprehensive investigation into the management of patients with root surface caries. [ABSTRACT FROM AUTHOR]

Background Patient perception with fixed appliance orthodontic treatment is important to improve oral health-related quality of life. Objective The main objective of this study was to evaluate the impact of labial fixed appliance orthodontic care on patient perception before, during, and after the treatment. Search methods Relevant systematic reviews investigating patient perception with fixed appliance orthodontic treatment were identified by searching electronic databases: MEDLINE via OVID (1946 to 31 December 2018), EMBASE (1974 to 31 December 2018), AMED (Allied and Complementary Medicine Database; 1985 to November 2018), PubMed (inception to 31 December 2018), Web of Science (1900 to 2018), and PsychINFO (1806 to 31 December 2018). Ongoing systematic reviews were searched using Prospero and a grey literature search was undertaken using Google Scholar and OpenGrey (www.opengrey.eu/). No language restriction was applied. Selection criteria Only studies investigating patient perception of fixed appliance orthodontic treatment were included. Data collection and analysis Screening, quality assessment [using the AMSTAR 2 tool (A Measurement Tool to Assess Systematic Reviews)], and data extraction were performed by two authors independently. Information was categorized and narratively synthesized for the key findings. Results A total of 163 articles investigating patient expectation, experience, and satisfaction with conventional ligation labial fixed orthodontic appliances were obtained. Of these, 152 observational or interventional studies were excluded, resulting in 11 eligible systematic reviews. Two were excluded as earlier reports of a Cochrane review. The quality of the reviews was variable (critically low, low, and moderate). The findings were as follows: aesthetics represents a primary motive for orthodontic treatment; a temporary deterioration in the quality of life occurs during the initial phases of treatment; gender and ethnicity factors do not have an impact on patient perception of treatment; and a positive relationship between orthodontist–patient–parent is important to achieve patient compliance and satisfaction. Conclusions There is a lack of high-quality studies in terms of systematic reviews and meta-analyses for assessing patient perception with fixed appliance orthodontic treatment. The aesthetic impact of malocclusion is the main motive for seeking orthodontic treatment. Quality of life reduces during the initial stages of orthodontic treatment but improves in the later stages of treatment. Assessment before, during, and after orthodontic treatment is necessary to comprehensively assess patient perception at all stages of care. Trial registration CRD42019122653. Conflict of Interest None to declare. [ABSTRACT FROM AUTHOR]