1. Sinus Node Sparing Hybrid Thoracoscopic Ablation Outcomes in Patients with Inappropriate Sinus Tachycardia (SUSRUTA-IST) Registry
- Author
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Ken Frazier, Poojita Shivamurthy, Dhanunjaya Lakkireddy, Rangarao Tummala, Gian-Battista Chierchia, Chandra Vasamreddy, Amin Al-Ahmad, Rakesh Gopinathannair, Scott Koerber, Mark LaMeier, Andrea Natale, Peter J. Park, Alap Shah, Jalaj Garg, Carlo DeAsmundis, Ahmed Romeya, Donita Atkins, Yashi Awasthi, Luigi Di Biase, Justin Vanmeetren, Sudha Bommana, Clinical sciences, Heartrhythmmanagement, Vascular surgery, Surgical clinical sciences, and Cardiac Surgery
- Subjects
Epicardial Mapping ,Male ,Reoperation ,medicine.medical_specialty ,medicine.medical_treatment ,Postural orthostatic tachycardia ,sinus node ,Inferior vena cava ,surgery ,Young Adult ,Postoperative Complications ,Arrhythmias ablation ,Superior vena cava ,Physiology (medical) ,Heart rate ,medicine ,Humans ,Prospective Studies ,Registries ,Sinus (anatomy) ,hybrid ablation ,business.industry ,Thoracoscopy ,Hybrid therapy ,medicine.disease ,Ablation ,Inappropriate sinus tachycardia ,inappropriate sinus tachycardia ,Surgery ,Tachycardia, Sinus ,medicine.anatomical_structure ,medicine.vein ,Catheter Ablation ,Female ,Cardiology and Cardiovascular Medicine ,business ,Crista terminalis ,Complication - Abstract
BACKGROUND: Medical treatment of inappropriate sinus tachycardia (IST) remains suboptimal. Radiofrequency sinus node (RF-SN) ablation has poor success and higher complication rates. OBJECTIVE: We aimed to compare clinical outcomes of the novel SN sparing hybrid ablation technique with those of RF-SN modification for IST management. METHODS: This is a multicenter prospective registry comparing the SN sparing hybrid ablation strategy with RF-SN modification. The hybrid procedure was performed using an RF bipolar clamp, isolating superior vena cava/inferior vena cava with the creation of a lateral line across the crista terminalis while sparing the SN region (identified by endocardial 3-dimensional mapping). RF-SN modification was performed by endocardial and/or epicardial mapping and ablation at the site of earliest atrial activation. RESULTS: Of the 100 patients (hybrid ablation group, n = 50; RF-SN group, n = 50), 82% were women, and the mean age was 22.8 years. Normal sinus rhythm and rate were restored in all patients in the hybrid group (vs 84% in the RF-SN group; P = .006). Hybrid ablation was associated with significantly better improvement in mean daily heart rate and peak 6-minute walk heart rate compared with RF-SN ablation. The RF-SN group had a significantly higher rate of redo procedures (100% vs 8%; P < .001), phrenic nerve injury (14% vs 0%; P = .012), lower acute pericarditis (48% vs 92%; P < .0001), permanent pacemaker implantation (50% vs 4%; P < .0001) than did the hybrid ablation group. CONCLUSION: The novel sinus node sparing hybrid ablation procedure appears to be more efficacious and safer in patients with symptomatic drug-resistant IST with long-term durability than RF-SN ablation.
- Published
- 2022