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Objectives: Introduction Fractal analysis (FA) is a computational method used to quantify the complex trabecular structure of bone. While FA has been widely applied in dentistry, there are challenges in standardizing the technique due to factors such as image resolution, region of interest (ROI) selection, and image processing. This study aimed to investigate the impact of the direction of ROI selection (DROIS) on fractal dimension (FD) calculations., Methods: Panoramic radiographs of 226 individuals aged 20-35 years were analyzed. ROIs were selected on the mandibular condyle, angular region, and mental region, and oriented at 0°, 22.5°, 45°, and 67.5° angles. FD was calculated using the box-counting method in ImageJ. The Friedman test and Wilcoxon signed-rank test were used for statistical analysis., Results: The FD values differed significantly between the angled ROI groups in all three regions (Friedman test, p < 0.0001). Pairwise comparisons showed significant differences in FD between most ROI orientations, except between 22.5° and 67.5° in the angular region., Conclusions: DROIS is an important factor that should be considered in FA studies to ensure reliable and reproducible FD values. Appropriate methodological choices can help account for the influence of DROIS on FD calculations.., Competing Interests: Declarations Conflict of interest There is no conflict of interest among authors. Ethical approval All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from all patients for being included in the study., (© 2024. The Author(s) under exclusive licence to Japanese Society for Oral and Maxillofacial Radiology.)

Aims: Benralizumab, a humanized, afucosylated monoclonal antibody against the interleukin 5 receptor, α subunit, causes rapid depletion of eosinophils by antibody-dependent cellular cytotoxicity. We investigated the pharmacokinetic and pharmacodynamic effects of benralizumab in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) from the phase III OSTRO trial., Methods: Patients received a placebo or 30 mg of benralizumab by subcutaneous injection every 8 weeks (first three doses every 4 weeks) to week 48; a subset of patients continued in an extended follow-up period to assess treatment durability to week 80. Serum benralizumab concentrations and blood eosinophil and basophil counts were assessed to week 80. Biomarker assessments were performed on nasal polyp tissue biopsies at week 56 and nasal lining fluid at weeks 24 and 56 to examine changes in immune cells and inflammatory mediators., Results: Among 185 patients in this analysis, 93 received benralizumab. Serum benralizumab concentrations reached a steady state by week 24 (median concentration 385.52 ng mL -1 ); blood eosinophils were almost fully depleted and blood basophils were reduced between weeks 16 and 56. Nasal polyp tissue eosinophils decreased with benralizumab from 57.6 cells mm -2 at baseline to 0 cells mm -2 at week 56 (P < .001 vs placebo), and tissue mast cells were numerically reduced. In nasal lining fluid, eosinophil-derived neurotoxin was significantly reduced at weeks 24 and 56 (P < .001) and interleukin-17 at week 56 (P < .05) with benralizumab., Conclusion: Benralizumab treatment led to rapid, sustained, nearly complete depletion of eosinophils from blood and nasal polyp tissue in patients with CRSwNP., (© 2024 AstraZeneca. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.)

Objective: The aim of this study is to evaluate the knowledge and awareness levels of patients who have at least one impacted tooth and who had previously applied to the dentist., Study Design: This study was conducted in patients aged 15 years and older who applied to Ordu University Faculty of Dentistry for routine examination and agreed to fill out the questionnaire form. A total of 325 people participated in the survey conducted to determine the awareness of patients applying to the faculty of dentistry about their existing impacted teeth. A Pearson's chi-square test was used for hypothesis testing when expected frequencies exceeded 5., Results: It was determined that 56.9 % (185) of the participants were aware of their existing teeth, while 43.1 % (140) were not aware. When the patients were evaluated according to the institutions they had visited, it was seen that the group who were most aware of the presence of impacted tooth were those who apply to the faculty of dentistry (74.4 %). The rate of being informed by dentists in the institutions that they had previously visited was higher in patients with university or post-university graduates (p < 0.05). The most common information given by the dentists to the patients about their impacted dental problems was that the tooth should be followed up (40.4 %), while the removal of the tooth constituted 28.4 % of the information given., Conclusion: This study showed that although patients are aware of their existing impacted teeth, their level of knowledge about the risks it may pose is low. For a healthy oral care and health, patients should be adequately informed about impacted teeth., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Author(s).)

The ability to effectively represent microbiome dynamics is a crucial challenge in their quantitative analysis and engineering. By using autoencoder neural networks, we show that microbial growth dynamics can be compressed into low-dimensional representations and reconstructed with high fidelity. These low-dimensional embeddings are just as effective, if not better, than raw data for tasks such as identifying bacterial strains, predicting traits like antibiotic resistance, and predicting community dynamics. Additionally, we demonstrate that essential dynamical information of these systems can be captured using far fewer variables than traditional mechanistic models. Our work suggests that machine learning can enable the creation of concise representations of high-dimensional microbiome dynamics to facilitate data analysis and gain new biological insights., (© 2023. The Author(s).)

Objectives: The aim of this study is to recommend an automatic caries detection and segmentation model based on the Convolutional Neural Network (CNN) algorithms in dental bitewing radiographs using VGG-16 and U-Net architecture and evaluate the clinical performance of the model comparing to human observer., Methods: A total of 621 anonymized bitewing radiographs were used to progress the Artificial Intelligence (AI) system (CranioCatch, Eskisehir, Turkey) for the detection and segmentation of caries lesions. The radiographs were obtained from the Radiology Archive of the Department of Oral and Maxillofacial Radiology of the Faculty of Dentistry of Ordu University. VGG-16 and U-Net implemented with PyTorch models were used for the detection and segmentation of caries lesions, respectively., Results: The sensitivity, precision, and F-measure rates for caries detection and caries segmentation were 0.84, 0.81; 0.84, 0.86; and 0.84, 0.84, respectively. Comparing to 5 different experienced observers and AI models on external radiographic dataset, AI models showed superiority to assistant specialists., Conclusion: CNN-based AI algorithms can have the potential to detect and segmentation of dental caries accurately and effectively in bitewing radiographs. AI algorithms based on the deep-learning method have the potential to assist clinicians in routine clinical practice for quickly and reliably detecting the tooth caries. The use of these algorithms in clinical practice can provide to important benefit to physicians as a clinical decision support system in dentistry., (© 2021. The Author(s) under exclusive licence to Japanese Society for Oral and Maxillofacial Radiology.)

Dynamical systems often generate distinct outputs according to different initial conditions, and one can infer the corresponding input configuration given an output. This property captures the essence of information encoding and decoding. Here, we demonstrate the use of self-organized patterns that generate high-dimensional outputs, combined with machine learning, to achieve distributed information encoding and decoding. Our approach exploits a critical property of many natural pattern-formation systems: in repeated realizations, each initial configuration generates similar but not identical output patterns due to randomness in the patterning process. However, for sufficiently small randomness, different groups of patterns that arise from different initial configurations can be distinguished from one another. Modulating the pattern-generation and machine learning model training can tune the tradeoff between encoding capacity and security. We further show that this strategy is scalable by implementing the encoding and decoding of all characters of the standard English keyboard., Competing Interests: The authors declare no competing interests., (© 2022 The Author(s).)

Bitewing radiographic imaging is an excellent diagnostic tool for detecting caries and restorations that are difficult to view in the mouth, particularly at the molar surfaces. Labeling radiological images by an expert is a labor-intensive, time-consuming, and meticulous process. A deep learning-based approach has been applied in this study so that experts can perform dental analyzes successfully, quickly, and efficiently. Computer-aided applications can now detect teeth and number classes in bitewing radiographic images automatically. In the deep learning-based approach of the study, the neural network has a structure that works according to regions. A region-based automatic segmentation system that segments each tooth using masks to help to assist analysis as given to lessen the effort of experts. To acquire precision and recall on a test dataset, Intersection Over Union value is determined by comparing the model's classified and ground-truth boxes. The chosen IOU value was set to 0.9 to allocate bounding boxes to the class scores. Mask R-CNN is a method that serves as instance segmentation and predicts a pixel-to-pixel segmentation mask when applied to each Region of Interest. The tooth numbering module uses the FDI notation, which is widely used by dentists, to classify and number dental items found as a result of segmentation. According to the experimental results were reached 100% precision and 97.49% mAP value. In the tooth numbering, were obtained 94.35% precision and 91.51% as an mAP value. The performance of the Mask R-CNN method used has been proven by comparing it with other state-of-the-art methods., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Objectives: Radiological examination has an important place in dental practice, and it is frequently used in intraoral imaging. The correct numbering of teeth on radiographs is a routine practice that takes time for the dentist. This study aimed to propose an automatic detection system for the numbering of teeth in bitewing images using a faster Region-based Convolutional Neural Networks (R-CNN) method., Methods: The study included 1125 bite-wing radiographs of patients who attended the Faculty of Dentistry of Ordu University from 2018 to 2019. A faster R-CNN an advanced object identification method was used to identify the teeth. The confusion matrix was used as a metric and to evaluate the success of the model., Results: The deep CNN system (CranioCatch, Eskisehir, Turkey) was used to detect and number teeth in bitewing radiographs. Of 715 teeth in 109 bite-wing images, 697 were correctly numbered in the test data set. The F1 score, precision and sensitivity were 0.9515, 0.9293 and 0.9748, respectively., Conclusions: A CNN approach for the analysis of bitewing images shows promise for detecting and numbering teeth. This method can save dentists time by automatically preparing dental charts.

Objectives: The aim of the present study is to identify the prevalence of radix entomolaris in mandibular first and second molars and to determine morphological classifications and associations with other root and canals., Methods: Mandibular first and second molar teeth of 850 Turkish patients were evaluated using cone-beam computed tomography. A total of 2800 mandibular first molars and second molars were screened. The CBCT examination was performed at five different axial levels. The prevalence of total radix entomolaris, unilateral-bilateral, right-left side and gender distributions, and the classification of radix entomolaris's canal configurations were measured., Results: Radix entomolaris was found in 2.9% (n = 25) of the patients and 1.2% (n = 34) of the teeth. The prevalence of radix entomolaris in mandibular first molars was higher than in mandibular second molars (p < 0.01), in males than in females (p < 0.05) and in right side than left side. An additional tubercle was found in 23% of the teeth with radix entomolaris. For buccolingual orientation, Type A canal variation was the highest and Type C canal variation was the lowest. Regarding locations of cervical parts, Type III canal variation was the highest while Type I canal variation was the lowest., Conclusions: The prevalence of radix entomolaris was lower in the Turkish population than in other Asian populations but, in multiethnic societies, it needs attention. Before starting endodontic treatment, the clinician should examine the radiography thoroughly and apply advanced radiography methods when necessary. Cone-beam computed tomography is a valuable advanced radiography method for assessing such anatomical variations in vivo.

Objective: The objective of this study is to evaluate the mental index (MI) and panoramic mandibular index (PMI) of a group of adolescent patients in different body mass index (BMI) percentile., Material and Methods: Subjects were divided into three different groups in accordance to their BMI percentile status: normal weight (35 subjects; mean age, 14.81 ± 2.12 years), overweight (32 subjects; mean age, 14.77 ± 2.56 years), and obese (33 subjects; mean age, 14.06 ± 2.59 years) groups. Mental index (MI) and panoramic mandibular index (PMI) were assessed on panoramic radiographs., Results: There were statistically significant differences in PMI and MI that were observed among groups (p < 0.0001 and p < 0.001, respectivel). MI and PMI are higher in overweight and obese individuals than in normal-weight., Conclusions: Mandibular cortex was found thicker in patients who are obese and overweight compared to normal weight patients. We can suggest that young obese individuals' bone structure can be take in consideration in orthodontic or dental surgical treatment planning., Clinical Relevance: Dense cortical bone may cause some difficulties in orthodontic and surgical treatment. Clinicians should understand obesity and overweight-related jaw bone changes and consider these factors to treat their patients.

The authors compared the morphological features of the Eustachian tube (ET) between patients with cleft lip and palate (CL/P) and normal controls using cone-beam computed tomography (CBCT). CBCT images of 51 CL/P patients (28 males and 23 females, mean age: 18.5 ± 8.0 years) and a control group of 52 patients (22 males and 30 females, mean age: 25.23 ± 10.65 years) were retrospectively evaluated. The Eustachian tube angle (ETA), Eustachian tube length (EL), and auditory tube angle (ATA) were measured on CBCT images. The ETA, EL, and ATA in the CL/P and normal control groups were 30.4 ± 6.2 and 36.7 ± 7.5°; 24.7 ± 3.7 and 27.7 ± 4.3 mm; and 142.4 ± 7.8 and 136.3 ± 4.1°, respectively. All between-group differences were statistically significant (all P < 0.05). There were no significant between-gender differences in either group (all P > 0.05). Continuous variables were compared using the Mann-Whitney U-test. The morphological features of the ET, measured via multiplanar reconstruction CBCT, differed between CL/P patients and normal controls. CBCT can be used to evaluate ET morphological features.

Objectives: Sella turcica bridging occurs with fusion or calcification of the anterior and posterior clinoid processes in the middle cranial region. This study aimed to compare the cephalometric parameters among normal shape, partial bridge, and total bridge of the sella turcica in adolescent and young adult subjects., Methods: This retrospective study was performed on the lateral cephalometric radiographs of 410 Turkish adolescent and young adult subjects. The subjects were divided into three groups: normal sella turcica shape (128 females, 32 males; mean age: 17.7 ± 1.54 years), partial sella turcica bridge (129 females, 32 males; mean age: 17.8 ± 2.15 years), and total sella turcica bridge (66 females, 23 males; mean age: 18.2 ± 1.82 years). Thirteen angular and eight linear cephalometric measurements were performed using a cephalometric software program. The data were analyzed by one-way analysis of variance, and the Kruskal-Wallis test with the Bonferroni correction., Results: Significant differences were found for Nperp-A distance, Nperp-Pg distance, and palatal plane-to-anterior cranial base angle among the groups (p < 0.016). There were no significant differences in the cephalometric parameters between the partial and total sella turcica bridging groups (p > 0.05)., Conclusions: This study evaluated a large amount of data for cephalometric measurements focusing on the degree of calcification of the sella turcica in adolescent and young adult subjects. The maxilla and mandible were located in a sagittally retrusive position in the partial and total sella turcica bridge subjects compared with the normal sella turcica shape subjects.

Based on a previous work where we investigated the effect of conditioner type and downforce on the evolution of pad surface micro-texture during break-in, we have chosen certain break-in conditions to carry out subsequent blanket SiO 2 wafer polishing studies. Two different conditioner discs were used in conjunction with up to two different conditioning downforces. For each disc-downforce combination, mini-marathons were run using SiO 2 wafers. Prior to polishing, each pad was broken-in for 30 min with one of the conditioner-downforce combinations. The goal of this study was to polish wafers after this break-in to see how the polishing process behaved immediately after break-in. One of the discs used in this study produced similar micro-texture results at both downforces, which echoed the results seen in the mini-marathon. When comparing the different polishing results obtained from breaking-in the pad with the different discs used in this study, the coefficient of friction (COF) and SiO 2 removal rate (RR) were uncorrelated in all cases. However, the use of different discs resulted in different COF and RR trends. The uncorrelated COF and RR, as well as the differing trends, were explained by pad micro-texture results (i.e. the differing amount of fractured, poorly supported pad asperity summits).

We investigated the possibility of employing refractive index (RI) measurements for inline incoming slurry control at the point of use (POU), as an alternative to the widespread densitometry method. As such, it became necessary to determine if RI could detect smaller changes in slurry composition and, therefore, provide a tighter control. Three industrially-relevant silica-based slurries, namely, Fujimi PL-7106, Klebosol 1501-50, and CMC W7801, were characterized using both densitometry and RI measurements. Initial solutions of the three slurries were prepared and increasingly small amounts of ultrapurified water (UPW) were added to study the change in slurry properties. Results showed that both density and RI decreased linearly with the addition of water for all three slurries, with the 1501-50 being the most sensitive to water addition. A linear correlation between the two properties was found, with R² values that exceeded 0.95 in all cases. Furthermore, the approximate limit of detection of both metrology tools was estimated based on the slope of the fitting line and resolution. When compared to densitometry, RI was found to be the far superior method for detecting smaller changes in water concentration.

In the original publication of the article in "Abstract", the sentence that reads as "The present analyses suggest that a steeper articular eminence inclination may be risk factor" should read as "As a result of our analysis, we concluded that a low eminence angle may be risk factor".

Objective: This study evaluated the prevalence and morphological characteristics of the superior semicircular canal (SSCC) in cleft lip and palate (CL/P) patients using cone beam computed tomography (CBCT)., Materials and Methods: CBCT images of 53 CL/P patients (28 males and 25 females) and a control group of 76 patients (42 males and 34 females) were evaluated. Retrospectively, 258 temporal bone images from 129 patients were evaluated in terms of SSCC morphology and divided into a normal pattern (0.6-1.7 mm in thickness), a papyraceous pattern (<0.5 mm), a thick pattern (>1.8 mm), a pneumatized pattern and dehiscent. The chi-squared test was used to compare differences among semicircular canal dehiscence (SSCD) patterns in the CL/P and control groups; p ≤ .05 was taken to reflect statistical significance., Results: The characteristics of the SSCC were evaluated on CBCT images in patients with CL/P and controls. In total, 158 (61%) cases were normal (0.6-1.7 mm in thickness), 31 (12%) papyraceous (<0.5 mm), 8 (3%) thick, and 34 (13%) pneumatized. SSCD was observed in 27 (11%) cases. Statistically significant differences between the CL/P and control groups were evident in terms of SSCC morphology (p < .001)., Conclusions: SSCD should be considered if a CL/P patient exhibits a vestibular system deficiency. Oral and maxillofacial radiologists should pay attention to SSCD when interpreting CBCT images. Future studies should use high-level spatial resolution CBCT to focus on cleft site and SSCC morphology in larger patient populations.

Previous studies have shown that spectral analysis based on force data can elucidate fundamental physical phenomena during chemical mechanical planarization (CMP). While it has not been literally described elsewhere, such analysis was partly motivated by modern violinmakers and physicists studying Old Italian violins, who were trying to discover spectral relations to sound quality. In this paper, we draw parallels between violins and CMP as far as functionality and spectral characteristics are concerned. Inspired by the de facto standard of violin testing via hammer strikes on the base edge of a violin's bridge, we introduce for the first time, a mobility plot for the polisher by striking the wafer carrier head of a CMP polisher with a hammer. Results show three independent peaks that can indeed be attributed to the polisher's natural resonance. Extending our study to an actual CMP process, similar to hammered and bowed violin tests, at lower frequencies the hammered and polished mobility peaks are somewhat aligned. At higher frequencies, peak alignment becomes less obvious and the peaks become more isolated and defined in the case of the polished wafer spectrum. Lastly, we introduce another parameter from violin testing known as directivity, Δ, which in our case, we define as the ratio of shear force variance to normal force variance acquired during CMP. Results shows that under identical polishing conditions, Δ increases with the polishing removal rate., Competing Interests: The authors declare no conflict of interest.

Objective: We examined the bone components of the temporomandibular joint (TMJ) in asymptomatic individuals and patients with temporomandibular dysfunction (TMD) using cone-beam computed tomography (CBCT)., Methods: Two hundred asymptomatic individuals and 200 patients with TMD were included in this study. Condyle position, eminence height, eminence inclination, condyle shape, and fossa shape were assessed on CBCT images of the 800 temporomandibular joints., Results: The eminence inclination (P < 0.05), eminence height (P < 0.0001), mediolateral width of condyle (P < 0.0001), and anterior joint space (P < 0.0001) were significantly greater in male subjects compared with female subjects in both the asymptomatic group and TMD group. Comparisons of the asymptomatic group and TMD group revealed significant differences in the anterior joint space (P < 0.0001), ratio of anterior joint space to posterior joint space (P < 0.001), posterior joint space (P < 0.05), eminence inclination (P < 0.05), eminence height (P < 0.05), condyle shape (P < 0.0001), and fossa shape (P < 0.05)., Conclusions: As a result of our analysis, we concluded that a low eminence angle may be risk factor for TMD. The presence of TMD was associated with the condyle position in the TMJ.

The aim of this study was to evaluate the morphologic structure of the frontal sinuses with postero-anterior cephalometric radiographs in Turkish adolescents and to compare the findings between genders. The study sample consisted of 148 subjects divided into two groups (74 male subjects; mean age: 14.55 ± 1.42 years-74 female subjects; mean age: 14.95 ± 1.80 years). The right and left maximum height and width of the frontal sinus, maxillary width, nasal width, cranial width, antegonial width parameters were measured in 148 postero-anterior cephalometric radiographs. The data were analyzed using independent t and Mann Whitney U test. Spearman correlation analyses were used to evaluate the relationships of the frontal sinus measurements and transversal cephalometric parameters. The mean values of the right and left frontal sinus width, maxillary width, antegonial width, and cranial width were larger in males than females (P < 0.05). The right frontal sinus height were positively correlated with antegonial width (r = 0.243; P < 0.05) and the right frontal sinus width were positively correlated with antegonial width (r = 0.327; P < 0.01) in males. The right frontal sinus width were positively correlated with nasal width (r = 0.244; P < 0.05) and the left frontal sinus width were positively correlated with nasal width (r = 0.231; P < 0.05) in females. Frontal sinuses were unique to each individual due to their morphological structures, and in forensic science, taking advantage of these features was very important for personal identification., (Copyright © 2017 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.)

Objective: The aim of this study was to assess the morphology of the sella turcica and measure its size in cleft and noncleft subjects., Material and Methods: Cone-beam computed tomography (CBCT) images of 54 individuals (29 males; 25 females) with cleft and 85 (22 males; 63 females) without cleft were used for this study. Syndromic patients with cleft(s) were not included because of possible additional endocrinological and/or morphological disorders. Linear measurements included length, depth, and diameter. The shape of the sella turcica was analyzed in the cleft and noncleft groups. An independent t test was conducted to evaluate differences between genders and groups. One-way ANOVA was used to compare age groups., Results: The length (p < 0.001) of the sella turcica was smaller in noncleft subjects than in cleft subjects. Diameter (p = 0.014) and depth (p = 0.005) showed as constantly increasing from an age <15 to >25 years in the overall assessment. The distribution of the shape of the sella turcica differed significantly between groups (p < 0.001)., Conclusions: In this study, CBCT was used to assess the morphology of the sella turcica. A majority of the subjects with cleft had a flattened sella turcica compared to that of the control group. A shorter length of the sella turcica was more evident in the cleft subjects than in the control group., (© 2016 S. Karger AG, Basel.)

Objective: The purpose of this study was to assess morphological shape and morphometric analysis of the sella turcica using cone beam computed tomography (CBCT) in different planes of section (coronal and sagittal)., Materials and Methods: CBCT images of 177 subjects of which 51 males and 126 females in the age group of 11 to 73 years were included in the study population. Linear dimensions which include the length, depth, diameter, and interclinoid distance were measured and the shape of sella turcica was analyzed., Results: Sella turcica had circular morphology in 69.5% of the subjects while flattened shape of sella turcica was observed in 16.4%, oval shape of sella turcica in 14%. There was no significant difference in the all measurements of sella turcica between males and females (P > 0.05). Diameter (P < 0.01), depth (P < 0.001), length (P < 0.05), and interclinoid distance (P < 0.05) of the sella turcica differed significantly with age., Conclusions: The anatomical structure of sella turcica can be studied effectively in CBCT images. Linear dimensions and shape of sella turcica in the current study can be used as reference standards for further investigations.

Stafne bone defects (SBDs) are asymptomatic radiolucent lingual/buccal bone lesions of the lower jaw and are frequently caused by soft tissue inclusion. These defects have a cystlike appearance on plain radiographs. The diagnosis of this defect is incidental because patients do not usually present clinical symptoms. The common variant of SBD exists at the third molar region of the mandible below the inferior alveolar canal. To date, only 1 case of multilocular SBD has been reported in the literature, including both clinical cases and archaeological specimens. The purpose of the current study was to describe a new case of multilocular appearance of SBD near the angle of the mandibula that was diagnosed with the aid of a three-dimensional cone beam computed tomographic scan.

This study was undertaken with a view to determine the acceptance and treatment possibilities of midazolam, depending upon its oral and rectal application for pediatric patients requiring an oral surgery procedure (tooth extraction) and having a pretreatment behavioral score of 1 or 2 according to the Frankl Scale. Oral (0.5 mg/kg) and rectal (0.35 mg/kg) midazolam was compared in view of acceptance of the mode of treatment and local anesthesia, level of amnesia, and adverse effects. Although oral or rectal midazolam application has similar characteristics in respect to ease of working, the oral midazolam application should generally be preferred because it is more easily accepted by pediatric patients.