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12 results on '"Yarovaya, Natalia"'

6. Human Aging and Global Function of Coenzyme Q10

Author

LINNANE, ANTHONY W., ZHANG, CHUNFANG, YAROVAYA, NATALIA, KOPSIDAS, GEORGE, KOVALENKO, SERGEY, PAPAKOSTOPOULOS, PENNY, EASTWOOD, HAYDEN, GRAVES, STEPHEN, and RICHARDSON, MARTIN

Published
2002

7. Marketing Management in the Sphere of Hotel and Tourist Services

Author

Goryushkina, Natalia Ye., Shkurkin, Dmitry V., Petrenko, Antonina S., DEMİN, Sergey Y., and YAROVAYA, Natalia S.

Subjects
services, lcsh:Management. Industrial management, lcsh:HD28-70, marketing, lcsh:Business, lcsh:HF5001-6182, competition, management, innovation, marketing,services,management,competition,innovation
Abstract

The relevance of marketing activity management study in the hotel and tourism business organizations is urgent due to increased competition for customers among the organizations of the industry and the tourism industry in general. Deepening competition among hotels hotel industry leads to the fact that the object of the competition is not only on accommodation rates, but also new kinds of proposals to stimulate and motivate consumers, quality, variety of programs to encourage repeat customers’ discounts, bonuses, etc. This action leads to the following actions, which greatly increases the importance of marketing research the hospitality industry, allowing identifying trends and areas for further development, management policy, and implementation of key performance indicators of the complex as a whole. Therefore, before each of the domestic hotel, a global hotel business there is a problem of search marketing management techniques that would strengthen a long time, and ensure its own stable position in the competition for the customer. Policy management marketing business hotel and tourist business of the country, the world's states and territories of the resort specialization in their methodology defines essential for efficient operation of a hotel-tourist complex full satisfaction of the needs of consumers of travel services, which suggests them in the necessary production and sales volume, range and quality required with the application of marketing concepts.

Published
2016

8. Tissue Mitochondrial DNA Changes: A Stochastic System

Author

KOPSIDAS, GEORGE, KOVALENKO, SERGEY A., HEFFERNAN, DAMIEN R., YAROVAYA, NATALIA, KRAMAROVA, LUDMILLA, STOJANOVSKI, DIANE, BORG, JUDY, ISLAM, MOHAMMED M., CARAGOUNIS, APHRODITE, and LINNANE, ANTHONY W.

Published
2000

9. Tissue Mitochondrial DNA Changes: A Stochastic System

Author

KOPSIDAS, GEORGE, primary, KOVALENKO, SERGEY A., additional, HEFFERNAN, DAMIEN R., additional, YAROVAYA, NATALIA, additional, KRAMAROVA, LUDMILLA, additional, STOJANOVSKI, DIANE, additional, BORG, JUDY, additional, ISLAM, MOHAMMED M., additional, CARAGOUNIS, APHRODITE, additional, and LINNANE, ANTHONY W., additional

Published
2006
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12. Cellular redox activity of coenzyme Q10: effect of CoQ10 supplementation on human skeletal muscle.

Author

Linnane AW, Kopsidas G, Zhang C, Yarovaya N, Kovalenko S, Papakostopoulos P, Eastwood H, Graves S, and Richardson M

Subjects
Aged, Case-Control Studies, Coenzymes, Cytoprotection, Dietary Supplements, Gene Expression Profiling, Gene Expression Regulation drug effects, Humans, Male, Middle Aged, Muscle Fibers, Skeletal drug effects, Muscle Fibers, Skeletal metabolism, Muscle, Skeletal metabolism, Oligonucleotide Array Sequence Analysis, Oxidation-Reduction, Proteome, Up-Regulation, Antioxidants pharmacology, Muscle, Skeletal drug effects, Ubiquinone analogs & derivatives, Ubiquinone pharmacology
Abstract

In this paper, we report results obtained from a continuing clinical trial on the effect of coenzyme Q10 (CoQ10) administration on human vastus lateralis (quadriceps) skeletal muscle. Muscle samples, obtained from aged individuals receiving placebo or CoQ10 supplementation (300mg per day for four weeks prior to hip replacement surgery) were analysed for changes in gene and protein expression and in muscle fibre type composition. Microarray analysis (Affymetrix U95A human oligonucleotide array) using a change in gene expression of 1.8-fold or greater as a cutoff point, demonstrated that a total of 115 genes were differentially expressed in six subject comparisons. In the CoQ10-treated subjects, 47 genes were up-regulated and 68 down-regulated in comparison with placebo-treated subjects. Restriction fragment differential display analysis showed that over 600 fragments were differentially expressed using a 2.0-fold or greater change in expression as a cutoff point. Proteome analysis revealed that, of the high abundance muscle proteins detected (2,086 +/- 115), the expression of 174 proteins was induced by CoQ10 while 77 proteins were repressed by CoQ10 supplementation. Muscle fibre types were also affected by CoQ10 treatment; CoQ10-treated individuals showed a lower proportion of type I (slow twitch) fibres and a higher proportion of type IIb (fast twitch) fibres, compared to age-matched placebo-treated subjects. The data suggests that CoQ10 treatment can act to influence the fibre type composition towards the fibre type profile generally found in younger individuals. Our results led us to the conclusion that coenzyme Q10 is a gene regulator and consequently has wide-ranging effects on over-all tissue metabolism. We develop a comprehensive hypothesis that CoQ10 plays a major role in the determination of membrane potential of many, if not all, sub-cellular membrane systems and that H2O2 arising from the activities of CoQ10 acts as a second messenger for the modulation of gene expression and cellular metabolism.

Published
2002
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