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3. The european organisation for research and treatment of cancer head and neck cancer module (EORTC QLQ-HN43): Estimates for minimal important difference and minimal important change

Author

Singer, Susanne, Hammerlid, Eva, Tomaszewska, Iwona M., Amdal, Cecilie D., Herlofson, Bente B., Santos, Marcos, Castro Silva, Joaquim, Mehanna, Hisham, Fullerton, Amy, Young, Teresa, Fernandez Gonzalez, Loreto, Inhestern, Johanna, Pinto, Monica, Arraras, Juan I., Yarom, Noam, Bonomo, Pierluigi, Baumann, Ingo, Galalae, Razvan, Nicolatou-Galitis, Ourania, Kiyota, Naomi, Raber-Durlacher, Judith, Salem, Dina, Fabian, Alexander, Boehm, Andreas, Krejovic-Trivic, Sanja, Chie, Wei-Chu, Taylor, Katherine J., Sherman, Allen C., Licitra, Lisa, Machiels, Jean-Pascal, and Bjordal, Kristin

Published
2024
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4. Guidance on mucositis assessment from the MASCC Mucositis Study Group and ISOO: an international Delphi study

Author

Laheij, Alexa, Tonkaboni, Arghavan, Scott, Jacqui, Abasaeed, Rania, Kauzman, Adel, Flato, Adriana Do Socorro Lima, Gore, Adwaita, Hardman, Anne-Marie, Horvath, Agnes, Hovan, Allan, Al-Jamaei, Aisha, koizumi, Aya, Santos-Silva, Alan, Majorana, Alessandra, Giannini, Alexandre, Teixeira, Aléxia, Shazib, Muhammad Ali, Melvin, Alison, Filho, Aluísio Miranda, Gruza, Amanda, Brown-Dahl, Amber, Harilall, Amit, El Maghrabi, Amr, Rogulj, Ana Andabak, Curvo, Ana Raphaela, Soares, Ana Laura, Stringer, Andrea, Moreira, Andréa, Kurtzweil, Andy, Salaberry, Angelyn, Blazy, Anne, Gussgard, Anne Margrete, Lynge Pedersen, Anne Marie, Freidank, Annette, Ariyawardana, Anura, Ramseier, Adrian, Arends, Jann, Blanchard, Ariel, Paz, Adriana Sesti, Thermann, Angela, Poropat, Augusto, Freites-Martinez, Azael, Al-Azri, Abdul Rahman, Herlofson, Bente Brokstad, BalajiSubramanian, Sitaraman, Ballantyne, Barbara, Bektas-Kayhan, Kivanc, Hasséus, Bengt, Kaffenberger, Benjamin, Benites, Bernar, Kwong, Bernice, Test, Beth, Chiantia, Fernando, Pettersson, Bo, Framroze, Bomi, Bonomo, Pierluigi, Brzak, Božana Lončar, Dulmage, Brittany, Buga, Sorin, Spekssnijder, Caroline, Brown, Carlton, Melo, Antonio Carlos Moura de, Ribeiro, Ana Carolina, Silva, Caroline, Fulop, Caroline, Anderson, Carryn, Flaitz, Catherine, Massoud, Cathy, Migliorati, Cesar, Gross, Callie, Gandini, Chiara, Loprinzi, Charles, de Mooij, Charlotte, Hong, Catherine, Choi, Ying Chu, Choy, Maria, Boers-Doets, Christine, Schmeel, Leonard, Nagano, Cibele, Franco, Maria Coeli, Subramaniam, Courtney, Patrick, Carolyn, Poh, Catherine, Neuenschwander, Cristina, Virgen, Cesar, Riesenbeck, Dorothea, Weaver, Dale, Goldemberg, Daniel Cohen, Sundaresan, Daniel, Nunes, Daniela, Perez, Danyel, Travassos, Daphine, Yang, David, Ribeiro, Daniela, Kolbinson, Dean, Buick, Deborah, Saunders, Deborah, De Bortolli, Juliane, Chugh, Deepika, Markstrom, Denise, Travassos, Denise, Weikel, Dianna, Galiti, Dimitra, Peiris, Dinusha, Djordjevic, Fedja, Singhai, Pankaj, Keefe, Dorothy, Peterson, Douglas, Fonseca, Douglas, Pon, Doreen, Kovalenko, Iuliia, Polonskaia, Aleksandra, Caldas, Rogério, Saganski, Kevin, Néri, Julia, Abbott, Dennis, Yergolkar, Abhijna Vithal, Del Conte, Cristina, Passos, Januaria, Uezu, Katia, Silva, Paula, Gilbert, Steven, Yeoh, Keng, Jain, Kunal, Rastogi, Madhup, Sankaran, Satheeshkumar Poolakkad, Manne, Deborah, Shatokhina, Evgeniya, Adebayo-Olojo, Esther, Somogyi-Ganss, Eszter, Ehrenpreis, Eli, Bernaola-Paredes, Wilber, Fregnani, Eduardo, Cardoso, Elaci, Bardellini, Elena, Arvanitou, Eleni, Fontes, Elisa Kauark, Bruning, Elise, Neumann, Eloise, Madureira, Elsa, Ramires, Marcia, Papadopoulou, Erofili, Munhoz, Etiene, Spijkervet, Fred, Granzotto, Fabiana, Martins, Fabiana, Alves, Fabio, Mougeot, Farah, Aielli, Federica, Pigatti, Fernanda, Fonseca, Fernanda, Samim, Firoozeh, Carvalho, Flavia, Zelaya, Florence Cuadra, Freytes, Cesar, da Silveira, Gabriela, Torino, Gabriela, Martins, Gabriela, Silva, Geisa, Caro, Gemma, Bryan, Gemma, Radford, Georgette, Al-Qadami, Ghanyah, Albini, Giorgia, Mainville, Gisele, Gkardiakos, Georgios, Potter, Gleidston, Hoeberechts, Gulbin, Howarth, Gordon, Ottaviani, Giulia, Bradley, Grace, Verma, Gunjan, Santos, Gustavo dos, Randles-Guzzardi, Margaret, Engelbrecht, Hanlie, Wardill, Hannah, Hansen, Heidi, Hasan, Iquebal, Hata, Hironobu, Ullgren, Helena, Antunes, Heliton Spindola, Laís dos Santos, Heloísa, Weld, Howard, McInnes, Helen, Jungbluth, Hans Peter, Weng, Hsiaofen, Hewson, Ian, Santos, Ingrid, Illarramendi, Jorge, Semendric, Ines, Menge, Rol, Von Bultzingslowen, Inger, Melo, Maria da Gloria de, Leong, Iona, Fonseca, Isabella, Kalif, Isadora, Carroll, James, Coller, Janet, Beck-Mannagetta, Johann, Bowen, Joanne, Meurer, Jose, McCullough, Ricky, Powers, Jennifer, Gomez, Jesus, Lenjisa, Jimma, jaya Vangara, Leko, Jasna, Fall-Dickson, Jane, Mougeot, Jean-Luc, Fox, Joan, Epstein, Joel, Robijns, Jolien, Wu, Jonn, Palma, Patricio, Amaram-Davila, Jaya, Siderov, Jim, Raber-Durlacher, Judith, Dantas, Juliana, Jasper, Juliana, Monteiro, Juliana, Bruno, Julia, julie pfeffer, Ristivojevic, Julija Jovanovic, Brito, Juliana, Kuriakose, Jyothsna, Kabasawa, Yuji, Dave, Kanan, Barczyszyn, Karin, Lima, Karol Sartori, Secombe, Kate, White, Kate, Cooper, Kate, Katsura, Kouji, Biggs, Karen, Ciarrocca, Katharine, Dennis, Kristopher, Tomizuka, Ken, Hendler, Kevin, Komo, Ikuko, Skallsjö, Kristina, Hodgins, Kristy, Rupel, Katia, Tanaka, Keiko, Kurup, Seema, Gueiros, Luiz, Agatti, Larissa, Garzona-Navas, Laura, Guerra, Letícia, Portela, Leila, Iossi, Leilani, Elting, Linda, Baad-Hansen, Lene, Reeder, Leslie, Lang, Leticia, Menezes, Liciane, Braun, Liliana, Grando, Liliane, Lim, Mathew, Fernandez, Lina, McKeage, Lucy, Campos, Luana, Simonato, Luciana, Muniz, Luciana, van Draanen, Leah, Mizutani, Mieko, Huang, Tsai-Wei, Riad, Mahfujul, Nazar, Mahnoor, Souza, Maíra, Minamisako, Mariana, Pereira, Manoela, Mantelato, Carlos, Diniz-Freitas, Márcio, Montezuma, Marco, Andrade, Marco, Santos, Marcos, Gobbo, Margherita, Fortuna, Maria Caterina, Vitor, Mariana, Marinho, Joana, Markova, Alina, Knuchel, Marlyse, Carlesimo, Marta, Neves, Marta, Mazar, Andrew, Gomez Amarilla, Maria Cristina, Chambers, Mark, Araujo, Melissa de, Melo, Alexandre, Cole, Melody, Elsayed, Mohamed, Fliedner, Monica, Hauer-Jensen, Martin, Bouchacourt, Micaela, Brennan, Michael, Thirlwell, Michael, Nakamura, Michio, Nakagaki, Midori, Rossi, Camila, Miller, Robert, Kaprilian, Mireille, Kase, Michael, Dougan, Michael, Stokman, Monique, Monsen, Ragnhild, Morgan, Alisha, Harding, Jocelyn, Taleghani, Maryam, Genot, Marie-Therese, Seshadri, Mukund, Muzyka, Brian, Batista, Nancy, Gadd, Nancy, Tanda, Naoko, Nasr, Narmin, Garcia, Natália, Lee, Nathan, Palmier, Natalia, Brito-Dellan, Norman, Corbitt, Nancy, Pieralisi, Neli, Serrano, Verônica, Iacovelli, Nicola Alessandro, Blijlevens, Nicole, Sampaio, Norma Lúcia, Karra, Nour, Venkatesh, Niveditha, Yarom, Noam, Borin, Renata Cristina, Lemenchick, Olivia, Mendes, Ondina, Nicolatou-Galitis, Ourania, Shchitka, Vasiliy, Bossi, Paolo, Reis, Paula, Santos, Paulo Sérgio, Fernandez-Ortega, Paz, Parker, Ira, García, Raquel, Fritz, Peter, Peters, Edmund, Gardner, Pamela, Girons, Pierre Saint, Tiwari, Priya, Chaturvedi, Pravin, de Moraes, Tais, Andrade, Priscila, Nair, Raj, Gibson, Rachel, Gururaj, Rachita, Abdalla-Aslan, Ragda, Thota, Raghu, Lalla, Rajesh, Mendes, Rui Amaral, Prado, Raquel Almeida, Ongole, Ravikiran, Taybos, George, Mackey, Regina, Rego, Renata, Camilotti, Renata, Ferrari, Renata, Junior, Renato, Bensadoun, Rene-Jean, Logan, Richard, Sales, Roberta, Zanicotti, Roberta, Tunes, Roberta, Mauceri, Rodolfo, Feitoza, Rosiene, Ruddy, Kathryn, Rybczyk, Cynthia, Trager, Stephanie, Mitsunaga, Sachiyo, Gunathilake, Sahani, Saini, Rajan, Salvestrini, Viola, Mukhopadhyay, Sandip, Angeloz, Sandrina, Sankar S, Pramod, Barbosa, Luciana S Barbosa, Volkova, Elena, Elad, Sharon, Cantoreggi, Sergio, Gordon, Sharon, Brown, Shelly, Janine Tam, Shu Yie, Faleiro, Sibelle, da Silva, Silmara, de Oliveira, Silvia, Jensen, Siri Beier, Skrinjar, Ivana, Beaumont, Sophie, Sperandio, Felipe, Reese, Sandra, Roser, Steven, Seo, Sachiko, van Leeuwen, Stephanie, Sonis, Stephen, Bernard, Stephen, Samuel, Stephen Rajan, Taylor, Stuart, Maitra, Suranjan, Skulski, Susanne, Carlisle, Suzanne, Avon, Sylvie Louise, Yokota, Tomoya, Yurikusa, Takashi, Polvora, Tabata Santos, Kelock, Tabitha, Fernandes, Tauana, Wain, Taylor, Brown, Timothy, Tetsuhito konishi, Ferreira, Thalyta Amanda, Kataoka, Tomoko, Kelly, Thomas, Mori, Takehiko, Higuchi, Tomoko, Saeki, Toshiaki, Tsoukalas, Nikolaos, De Vandeul, Typhaine Maupoint, Usubuchi, Masatoshi, Lacerda, Vanessa, Tilly, Vanessa, Vigarios, Emmanuelle, Villa, Alessandro, Torregrossa, Vinicius, Selvaraj, Vinodh Kumar, Sarmento, Viviane, Heng, Vivien, Gomes-Silva, Wagner, Kandwal, Abhishek, Wilberg, Petter, Miranda e Silva, Wanessa, I'zzah Wan Mohamad Zain, Wan Nor, Park, Wonse, Tissing, Wim, Soga, Yoshihiko, Van Sebille, Bella, Matsuda, Yuhei, Zadik, Yehuda, Cao, Katrina, Cheung, Yin Ting, Fregnani, Eduardo Rodrigues, Van Sebille, Ysabella, Kauark-Fontes, Elisa, McCurdy-Franks, Emma, Finkelstein, Joel, McCarvell, Victoria, Amaral Mendes, Rui, Speksnijder, Caroline Margina, and Wardill, Hannah Rose

Published
2024
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6. Companding algorithm for the detection of malignant lesions in HDR CT mandibular images

Author

Tamir, Yuval, Spitzer, Hedva, Yarom, Noam, Barkan, Yuval, Barenboim, Silvina Friedlander, and Dobriyan, Alex

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Physics - Medical Physics
Abstract

Compressing and expanding (companding) HDR computerized tomography (CT) images to a single LDR image is still a relevant challenge. Besides the general need for simplification of the window setting method for the purpose of diagnosis, there are specific clinical needs for the resection of malignant lesions in the mandible, for example, where the lesions may exist in both the soft tissue and the bone. A successful medical algorithm has to take into account the requirement to variously expose the same range of specific gray levels, when they are presented by different body tissues. As a solution, we propose an adaptive multi-scale contrast companding (AMCC) algorithm that is implemented by using soft threshold separation to two channels (bone and soft tissue). This separation is determined by the HU intensity values (that are already computed in the algorithm) in the specific resolution that is best fitted to the teeth. Each channel contains different set of parameters. The AMCC algorithm successfully and adaptively compands a large variety of mandibular CT HDR images as well as natural images. Two collaborating physicians who evaluated tumor boundaries, by the 'single presentation' method, reported that 92% of the algorithm output images were at least as useful for diagnosis as those in the window method, while 50% of the algorithm output images were better. When each slice was evaluated simultaneously, by the window setting method (bone and soft tissue) and algorithm output images, 93% of the evaluations declared a preference for the output images of the algorithm. We describe here a low-cost method for companding the HDR images with the ability to facilitate resections of mandibular lesions by providing optimal boundary definition., Comment: 10 pages, 4 figures

Published
2020

10. Methodological approach for determining the Minimal Important Difference and Minimal Important Change scores for the European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module (EORTC QLQ-HN43) exemplified by the Swallowing scale

Author

Singer, Susanne, Hammerlid, Eva, Tomaszewska, Iwona M., Amdal, Cecilie Delphin, Bjordal, Kristin, Herlofson, Bente Brokstad, Santos, Marcos, Silva, Joaquim Castro, Mehanna, Hisham, Fullerton, Amy, Brannan, Christine, Gonzalez, Loreto Fernandez, Inhestern, Johanna, Pinto, Monica, Arraras, Juan I., Yarom, Noam, Bonomo, Pierluigi, Baumann, Ingo, Galalae, Razvan, Nicolatou-Galitis, Ourania, Kiyota, Naomi, Raber-Durlacher, Judith, Salem, Dina, Fabian, Alexander, Boehm, Andreas, Krejovic-Trivic, Sanja, Chie, Wei-Chu, Taylor, Katherine, Simon, Christian, Licitra, Lisa, and Sherman, Allen C.

Published
2022
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12. Overcoming local anesthesia failure during routine dental treatments in children.

Author

Yagudaev, Michael, Yarom, Noam, and Ashkenazi, Malka

Subjects
MOLARS, LOCAL anesthesia, MEDICAL care, DENTAL therapists, RETROSPECTIVE studies, TREATMENT failure, DENTAL extraction, NERVE block, EVALUATION, CHILDREN
Abstract

Background: Local anesthesia (LA) during routine dental treatment in children fails in 5%–35% of first attempts. No data, however, are available on the success rates of subsequent attempts. Aim: To evaluate the effectiveness of primary, secondary, and tertiary LA attempts (P‐LA, S‐LA, and T‐LA, respectively) for anesthetizing molars during routine dental treatments in children. Design: We retrospectively analyzed dental records of all children (2–18 years) who had been administered LA for the treatment of primary or permanent molars by a single paediatric dentist, between 2011 and 2022. All LAs were delivered using a computer‐controlled local anesthetic delivery (CCLAD) system. Results: The failure rate of P‐LA in 1312 molars was 13% and correlated with age (p <.001), type of tooth (p <.001), type of treatment (p <.001), and treated arch (p <.001). The effectiveness of S‐LA for buccal infiltration, intrasulcular, inferior alveolar nerve block, greater palatine nerve block (GPNB), posterior superior alveolar nerve block (PSANB), or a combination of the last two was 50%, 87.2%, 66.7%, 63.6%, 33.3%, and 100%, respectively, and was not significantly associated with age or the type of tooth, treatment, or P‐LA. Conclusion: The optimal choice of S‐LA for anesthetizing maxillary molars was a combination of PSANB and GPNB, whereas for mandibular molars, it was IS‐CCLAD system. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Prevention and Management of Osteoradionecrosis in Patients With Head and Neck Cancer Treated With Radiation Therapy: ISOO-MASCC-ASCO Guideline

Author

Peterson, Douglas E., primary, Koyfman, Shlomo A., additional, Yarom, Noam, additional, Lynggaard, Charlotte Duch, additional, Ismaila, Nofisat, additional, Forner, Lone E., additional, Fuller, Clifton David, additional, Mowery, Yvonne M., additional, Murphy, Barbara A., additional, Watson, Erin, additional, Yang, David H., additional, Alajbeg, Ivan, additional, Bossi, Paolo, additional, Fritz, Michael, additional, Futran, Neal D., additional, Gelblum, Daphna Y., additional, King, Edward, additional, Ruggiero, Salvatore, additional, Smith, Derek K., additional, Villa, Alessandro, additional, Wu, Jonn S., additional, and Saunders, Deborah, additional

Published
2024
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18. Management of oral herpes simplex virus infections: The problem of resistance. A narrative review.

Author

Piperi, Evangelia, Papadopoulou, Erofili, Georgaki, Maria, Dovrat, Sara, Bar Illan, Mor, Nikitakis, Nikolaos G., and Yarom, Noam

Subjects
VACCINE development, MICROBIAL virulence, IMMUNOCOMPROMISED patients, ACYCLOVIR, ANTIVIRAL agents, CLINICAL pathology, HERPESVIRUS diseases, ALTERNATIVE medicine, GENOME editing, HERPES simplex, DRUG resistance, NUCLEOSIDE reverse transcriptase inhibitors, PHENOTYPES, GENOTYPES
Abstract

Herpes Simplex Virus (HSV) type 1 (HSV‐1) and type 2 (HSV‐2) are among the most common human viral pathogens, affecting several billion people worldwide. Although in healthy patients clinical signs and symptoms of HSV infection are usually mild and self‐limiting, HSV‐infections in immunocompromised patients are frequently more aggressive, persistent, and even life‐threatening. Acyclovir and its derivatives are the gold standard antiviral drugs for the prevention and treatment of HSV infections. Although the development of acyclovir resistance is a rather uncommon condition, it may be associated with serious complications, especially in immunocompromised patients. In this review, we aim to address the problem of drug resistant HSV infection and discuss the available alternative therapeutic interventions. All relative studies concerning alternative treatment modalities of acyclovir resistant HSV infection published in PubMed between 1989 to 2022 were reviewed. Long‐term treatment and prophylaxis with antiviral agents predisposes to drug resistance, especially in immunocompromised patients. Cidofovir and foscarnet could serve as alternative treatments in these cases. Although rare, acyclovir resistance may be associated with severe complications. Hopefully, in the future, novel antiviral drugs and vaccines will be available in order to avoid the existing drug resistance. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements

Author

Yarom, Noam, Hovan, Allan, Bossi, Paolo, Ariyawardana, Anura, Jensen, Siri Beier, Gobbo, Margherita, Saca-Hazboun, Hanan, kandwal, Abhishek, Majorana, Alessandra, Ottaviani, Giulia, Pentenero, Monica, Nasr, Narmin Mohammed, Rouleau, Tanya, Lucas, Anna Skripnik, Treister, Nathaniel Simon, Zur, Eyal, Ranna, Vinisha, Vaddi, Anusha, Cheng, Karis Kin Fong, Barasch, Andrei, Lalla, Rajesh V., and Elad, Sharon

Published
2019
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23. Postoperative Excessive Bleeding following Stainless-Steel Crown Placement in Healthy Children with a Suggested Approach for Prevention

Author

Oren Liat, Spierer Shoshana, Friedlander Barenbaum Silvina, Yarom Noam, Ben-Amitai Dan, and Ashkenazi Malka

Subjects
General Dentistry
Abstract

Stainless-Steel Crown (SSC) placement is a common treatment in children, usually without significant adverse consequences. The present case series reports six healthy children were admitted to emergency rooms in two medical centers with delayed excessive bleeding from their gingiva, adjacent to newly placed SSCs. The bleeding, in some cases, was so extensive, that it induced vomiting and anxiety, among the children and their parents, and in two cases required surgical suturing. In all six cases, the most probable etiology was a toxic reaction to the released nickel or chromium ions from the SSCs, exacerbated by contact with wounded and bleeding gingiva. Expression of this cytotoxic mode of action, due to metal ions released from SSCs, is not well documented in children. Our aims are to raise awareness of this unique complication and to suggest an approach to minimize and prevent its occurrence. Recommended immediate treatment includes frequent rinsing of the gingiva to wash out released metal ions and decrease their toxic effect. Furthermore, in the following appointments, we recommend using only SSCs previously soaked in water for several weeks, using zirconia crowns, or using Hall’s technique when appropriate.

Published
2023

33. International field testing of the psychometric properties of an EORTC quality of life module for oral health: the EORTC QLQ-OH15

Author

Hjermstad, Marianne J., Bergenmar, Mia, Bjordal, Kristin, Fisher, Sheila E., Hofmeister, Dirk, Montel, Sébastien, Nicolatou-Galitis, Ourania, Pinto, Monica, Raber-Durlacher, Judith, Singer, Susanne, Tomaszewska, Iwona M., Tomaszewski, Krzysztof A., Verdonck-de Leeuw, Irma, Yarom, Noam, Winstanley, Julie B, Herlofson, Bente B., and on behalf of the EORTC QoL Group

Published
2016
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36. Basic oral care for hematology–oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT)

Author

Elad, Sharon, Raber-Durlacher, Judith E., Brennan, Michael T., Saunders, Deborah P., Mank, Arno P., Zadik, Yehuda, Quinn, Barry, Epstein, Joel B., Blijlevens, Nicole M. A., Waltimo, Tuomas, Passweg, Jakob R., Correa, M. Elvira P., Dahllöf, Göran, Garming-Legert, Karin U. E., Logan, Richard M., Potting, Carin M. J., Shapira, Michael Y., Soga, Yoshihiko, Stringer, Jacqui, Stokman, Monique A., Vokurka, Samuel, Wallhult, Elisabeth, Yarom, Noam, and Jensen, Siri Beier

Published
2015
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42. Correction to:Systematic review of natural and miscellaneous agents, for the management of oral mucositis in cancer patients and Clinical Practice Guidelines – Part 1: vitamins, minerals and nutritional supplements (Supportive Care in Cancer, (2019), 27, 10, (3997-4010), 10.1007/s00520-019-04887-x)

Author

Yarom, Noam, Hovan, Allan, Bossi, Paolo, Ariyawardana, Anura, Jensen, Siri Beier, Gobbo, Margherita, Saca-Hazboun, Hanan, Kandwal, Abhishek, Majorana, Alessandra, Ottaviani, Giulia, Pentenero, Monica, Nasr, Narmin Mohammed, Rouleau, Tanya, Lucas, Anna Skripnik, Treister, Nathaniel Simon, Zur, Eyal, Ranna, Vinisha, Vaddi, Anusha, Cheng, Karis Kin Fong, Barasch, Andrei, Lalla, Rajesh V., and Elad, Sharon

Abstract

The original version of this paper contains a typographical error in the units: g/day was incorrectly written as mg/day. Specifically, on page 4005, paragraph 6: These studies demonstrated that glutamine at a dose range of 10–30 mg/day, delivered throughout the RT-CT, may be effective to prevent OM. it should read: These studies demonstrated that glutamine at a dose range of 10–30 g/day, delivered throughout the RT-CT, may be effective to prevent OM.

Published
2021

43. The impact of COVID-19 lockdown on maintenance of children's dental health: A questionnaire-based survey

Author

Gotler, Maya, Oren, Liat, Spierer, Shoshanna, Yarom, Noam, and Ashkenazi, Malka

Subjects
Investigation, Parents, Toothbrushing, periodic dental examination, treatment, dental, COVID-19, eating habits, Oral Health, Dental Caries, stomatognathic diseases, stomatognathic system, Surveys and Questionnaires, Communicable Disease Control, Humans, tooth brushing, Child, Pandemics, caries
Abstract

The COVID-19 pandemic has been associated with several changes in maintenance of children's dental health. The aim of this study was to evaluate the extent of these changes.Parents were asked to respond anonymously to a questionnaire regarding alterations in their children's oral habits, such as frequency of eating and drinking, toothbrushing, signs of stress, and receiving oral health care during the lockdown period. The participants were reached either during their visit to the clinics or via the social media groups of the authors.There were 308 parents of children aged 1 through 18 years who responded to the questionnaires. The authors found associations between increased frequency of eating and drinking, decreased frequency of toothbrushing, and postponing oral health care. Among the children, 11% experienced more frequent oral signs of stress, such as temporomandibular disorder and aphthous stomatitis, during the lockdown. Although children from all age groups ate and drank more frequently between meals, younger children received a diagnosis of carious lesions more often during the lockdown (P = .015).During the lockdown, many children changed their eating, drinking, and toothbrushing habits and, thus, increased their risk of developing caries.During pandemic-associated re-care visits or recall visits, it is imperative to conduct a detailed interview regarding changes in oral health habits. In children at high risk, dentists recommended more diagnostic and preventive measures to prevent deterioration of their oral health. Moreover, dentists should put more emphasis on motivational interviewing to help children resume healthier routines after the lockdown.

Published
2021

45. International validation of the revised European Organisation for Research and treatment of cancer head and neck cancer module, the EORTC QLQ-HN43

Author

Singer, Susanne, Amdal, Cecilie Delphin, Hammerlid, Eva, Tomaszewska, Iwona M, Castro Silva, Joaquim, Mehanna, Hisham, Santos, Marcos, Inhestern, Johanna, Brannan, Christine, Yarom, Noam, Fullerton, Amy, Pinto, Monica, Arraras, Juan I, Kiyota, Naomi, Bonomo, Pierluigi, Sherman, Allen C, Baumann, Ingo, Galalae, Razvan, Fernandez Gonzalez, Loreto, Nicolatou-Galitis, Ourania, Abdel-Hafeez, Zeinab, Raber-Durlacher, Judith, Schmalz, Claudia, Zotti, Paola, Boehm, Andreas, Hofmeister, Dirk, Krejovic Trivic, Sanja, Loo, Suat, Chie, Wei-Chu, Bjordal, Kristin, Brokstad Herlofson, Bente, Grégoire, Vincent, Licitra, Lisa, EORTC Quality of Life and the EORTC Head and Neck Cancer Groups, Oral Medicine, Maxillofacial Surgery (AMC), Oral and Maxillofacial Surgery, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, and UCL - (SLuc) Service de radiothérapie oncologique

Subjects
Multimodal therapies, Quality of life, Male, medicine.medical_specialty, SDG 16 - Peace, Psychometrics, Intraclass correlation, Medizin, Sensitivity and Specificity, 03 medical and health sciences, 0302 clinical medicine, Cronbach's alpha, Surveys and Questionnaires, Validation, Outcome Assessment, Health Care, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Head and neck cancer, Reliability (statistics), Aged, Aged, 80 and over, business.industry, SDG 16 - Peace, Justice and Strong Institutions, Discriminant validity, Reproducibility of Results, Cancer, Middle Aged, medicine.disease, Combined Modality Therapy, Confirmatory factor analysis, humanities, Justice and Strong Institutions, 3. Good health, Europe, Chemoradiation, Otorhinolaryngology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Quality of Life, Physical therapy, Female, business
Abstract

Background: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43). Methods: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test–retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons. Results: Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded 0.40. The ICC was >0.70 in all but two scales. Differences in scale scores between known-groups were >10 points in 17 of the 19 scales. Sensitivity to change was found to be sufficient in 18 scales. Conclusions: Evidence supports the reliability and validity of the EORTC QLQ-HN43 as a measure of quality of life.

Published
2019

46. Measuring quality of life in patients with head and neck cancer: Update of the EORTC QLQ-H&N Module, Phase III

Author

Singer, Susanne, Araújo, Cláudia, Arraras, Juan Ignacio, Baumann, Ingo, Boehm, Andreas, Herlofson, Bente Brokstad, Silva, Joaquim Castro, Chie, Wei-Chu, Fisher, Sheila, Guntinas–Lichius, Orlando, Hammerlid, Eva, Irarrázaval, María Elisa, Hjermstad, Marianne Jensen, Jensen, Kenneth, Kiyota, Naomi, Licitra, Lisa, Nicolatou–Galitis, Ourania, Pinto, Monica, Santos, Marcos, Schmalz, Claudia, Sherman, Allen C., Tomaszewska, Iwona M., de Leeuw, Irma Verdonck, Yarom, Noam, Zotti, Paola, and Hofmeister, Dirk

Published
2015
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