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Background and Aim: Lichen Planus is a relatively common mucocutaneous disease which usually affects the oral mucosa. Patients with Oral Lichen Planus (OLP) suffer from symptoms that affect different aspects of their daily life. Although the exact etiology of OLP is unclear, the role of psychological disorders especially stress, anxiety and depression is debated. The aim of this study was to analyze mental health and oral health related quality of life in patients with OLP. Materials and Methods: In this case-control study, 35 patients with OLP along with 50 healthy people matched by age, sex and oral health level were involved. Both groups completed the GHQ-28 and OHIP-14 questionnaires. Oral examination was also performed. At the end, data were analyzed by SPSS v.18 software and Descriptive statistics, Chi Square Test, T-test and Mann-U- Whitney Test. Results: There were statistically significant differences in the functional limitation and physical disability aspects of OHIP-14 in patients with OLP in comparison with the normal group ( P =0/02(P= 0/03) respectively. Besides, there were no significant differences between the groups with respect to psychological disorders. ( P = 0/41) Conclusions: The quality of life in patients with OLP is reduced in some aspects. Moreover, our findings do not support a relation between OLP and psychological disorders. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate the radioprotective effect of thymol as a natural product against salivary glands dysfunction induced by ionizing radiation in rats. The rats were treated with thymol at dose of 50 mg/Kg before exposure to ionizing radiation at dose 15 Gy. Salivary gland function was evaluated with radioisotope scintigraphy and then salivary gland to background counts ratio was calculated. Ionizing radiation caused significant salivary glands dysfunction at the 3 th and the 70 th days with reduction in radioactivity uptake in salivary glands. Ratios of salivary gland to background radioactivities were 2.0 ± 0.05, 1.58 ± 0.62 and 1.99 ± 0.07 at 3 th days for control, radiation, and thymol plus radiation groups, respectively. Thymol significantly protected acute and chronic salivary gland dysfunction induced by ionizing radiation in the rats.This finding may have been a promising application of thymol for the protection of salivary glands dysfunction induced by ionizing irradiation in patients exposed to radiation in head and neck cancer therapy.

The purpose of this study is to investigate the radioprotective effect of vitamin E as a natural product. Vitamin E protects the salivary glands dysfunction that is induced by ionizing radiation. It was analysed with radioisotope scintigraphy and then salivary gland to background counts ratio was calculated. Histopathological evaluation was performed. The rats were treated with vitamin E at dose of 400IU/kg 48, 24, and 1h before 15Gy gamma rays irradiation. The rats were evaluated for the salivary gland function through nuclear medicine protocol. Radiation causes significant salivary glands dysfunction at the 3rd and the 70th days with a reduction in radioactivity uptake in the salivary glands. Ratios of salivary gland to background radioactivities were 1.99±0.11, 1.58±0.08 and 1.92±0.04 for control, radiation, and vitamin E plus radiation groups, respectively. Vitamin E significantly improved salivary gland dysfunction induced by ionizing radiation in the rats. In conclusion, our results indicate protective effects of vitamin E against salivary gland dysfunction induced by gamma radiation. Thus, vitamin E is a promising radioprotective agent for patients who receive radiation in head and neck cancer therapy., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Oncocytoma is a rare benign salivary gland tumor, which mostly occurs in the parotid gland. In this article, we describe an early onset of oncocytoma of minor salivary gland in a 36-year, white male. On clinical examination, we encounter with a painless, granular, sessile mass. After Excisional biopsy, the histopathological features revealed sheets of cells with abundant granular eosinophilic cytoplasm, and large, round nuclei that are known as "Oncocyte".