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131 results on '"Yap, Wai Ming"'

2. Early post-surgical recurrence of metastatic vertebral neuro-endocrine tumour treated effectively with chemo-radiotherapy

Author

Kaliya-Perumal Arun-Kumar, Tan Mark, Tee Seh Wee, Achudan Shaam, Yap Wai Ming, and Oh Jacob Yoong Leong

Subjects
Metastasis, Myelopathy, Neuroendocrine tumours, Spinal cord compression, Concurrent chemoradiotherapy, Medicine
Abstract

Spinal metastasis of neuro-endocrine tumours (NETs) usually arise from a primary in the lung. We encountered such a patient with NET metastasis to T6 vertebra causing severe cord compression. Considering the neurological status, immediate decompression surgery along with T3-T8 posterior stabilization was done. Early recurrence of the tumour causing near total obliteration of the spinal canal leading to significant neurological compromise was noted within one month of surgery. A second surgery at this stage was avoided due to the risk involved and concurrent chemo-radiotherapy was initiated. The tumour was sensitive to chemo-radiotherapy and rapid resolution was noted on subsequent follow-up visits. With appropriate rehabilitation, patient regained full power to become ambulant with support. This case report highlights a rare, early and aggressive recurrence of metastatic vertebral NET following index surgery which was effectively managed with chemo-radiotherapy.

Published
2019
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10. Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP)

Author

Lee, Jonathan W J, primary, Zhu, Feng, additional, Srivastava, Supriya, additional, Tsao, Stephen KK, additional, Khor, Christopher, additional, Ho, Khek Yu, additional, Fock, Kwong Ming, additional, Lim, Wee Chian, additional, Ang, Tiing Leong, additional, Chow, Wan Cheng, additional, So, Jimmy Bok Yan, additional, Koh, Calvin J, additional, Chua, Shijia Joy, additional, Wong, Andrew S Y, additional, Rao, Jaideepraj, additional, Lim, Lee Guan, additional, Ling, Khoon Lin, additional, Chia, Chung-King, additional, Ooi, Choon Jin, additional, Rajnakova, Andrea, additional, Yap, Wai Ming, additional, Salto-Tellez, Manuel, additional, Ho, Bow, additional, Soong, Richie, additional, Chia, Kee Seng, additional, Teo, Yik Ying, additional, Teh, Ming, additional, and Yeoh, Khay-Guan, additional

Published
2021
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29. Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP)

Author

Lee, Jonathan W J, Zhu, Feng, Srivastava, Supriya, Tsao, Stephen KK, Khor, Christopher, Ho, Khek Yu, Fock, Kwong Ming, Lim, Wee Chian, Ang, Tiing Leong, Chow, Wan Cheng, So, Jimmy Bok Yan, Koh, Calvin J, Chua, Shijia Joy, Wong, Andrew S Y, Rao, Jaideepraj, Lim, Lee Guan, Ling, Khoon Lin, Chia, Chung-King, Ooi, Choon Jin, Rajnakova, Andrea, Yap, Wai Ming, Salto-Tellez, Manuel, Ho, Bow, Soong, Richie, Chia, Kee Seng, Teo, Yik Ying, Teh, Ming, and Yeoh, Khay-Guan

Abstract

ObjectiveTo investigate the incidence of gastric cancer (GC) attributed to gastric intestinal metaplasia (IM), and validate the Operative Link on Gastric Intestinal Metaplasia (OLGIM) for targeted endoscopic surveillance in regions with low-intermediate incidence of GC.MethodsA prospective, longitudinal and multicentre study was carried out in Singapore. The study participants comprised 2980 patients undergoing screening gastroscopy with standardised gastric mucosal sampling, from January 2004 and December 2010, with scheduled surveillance endoscopies at year 3 and 5. Participants were also matched against the National Registry of Diseases Office for missed diagnoses of early gastric neoplasia (EGN).ResultsThere were 21 participants diagnosed with EGN. IM was a significant risk factor for EGN (adjusted-HR 5.36; 95% CI 1.51 to 19.0; p<0.01). The age-adjusted EGN incidence rates for patients with and without IM were 133.9 and 12.5 per 100 000 person-years. Participants with OLGIM stages III–IV were at greatest risk (adjusted-HR 20.7; 95% CI 5.04 to 85.6; p<0.01). More than half of the EGNs (n=4/7) attributed to baseline OLGIM III–IV developed within 2 years (range: 12.7–44.8 months). Serum trefoil factor 3 distinguishes (Area Under the Receiver Operating Characteristics 0.749) patients with OLGIM III–IV if they are negative for H. pylori. Participants with OLGIM II were also at significant risk of EGN (adjusted-HR 7.34; 95% CI 1.60 to 33.7; p=0.02). A significant smoking history further increases the risk of EGN among patients with OLGIM stages II–IV.ConclusionsWe suggest a risk-stratified approach and recommend that high-risk patients (OLGIM III–IV) have endoscopic surveillance in 2 years, intermediate-risk patients (OLGIM II) in 5 years.

Published
2022
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31. Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer

Author

Huang, Kie Kyon, primary, Ramnarayanan, Kalpana, additional, Zhu, Feng, additional, Srivastava, Supriya, additional, Xu, Chang, additional, Tan, Angie Lay Keng, additional, Lee, Minghui, additional, Tay, Suting, additional, Das, Kakoli, additional, Xing, Manjie, additional, Fatehullah, Aliya, additional, Alkaff, Syed Muhammad Fahmy, additional, Lim, Tony Kiat Hon, additional, Lee, Jonathan, additional, Ho, Khek Yu, additional, Rozen, Steven George, additional, Teh, Bin Tean, additional, Barker, Nick, additional, Chia, Chung King, additional, Khor, Christopher, additional, Ooi, Choon Jin, additional, Fock, Kwong Ming, additional, So, Jimmy, additional, Lim, Wee Chian, additional, Ling, Khoon Lin, additional, Ang, Tiing Leong, additional, Wong, Andrew, additional, Rao, Jaideepraj, additional, Rajnakova, Andrea, additional, Lim, Lee Guan, additional, Yap, Wai Ming, additional, Teh, Ming, additional, Yeoh, Khay Guan, additional, and Tan, Patrick, additional

Published
2018
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37. Abdominal pain in a patient with AIDS

Author

Tan, Kevin, Lim, Poh Lian, Yap, Wai Ming, and Tan, Soo Yong

Subjects
Cytomegalovirus infections -- Diagnosis, Cytomegalovirus infections -- Complications, Appendicitis -- Diagnosis, AIDS patients -- Care and treatment, Health, Health care industry
Published
2004

41. Recurrence of pulmonary acinic cell carcinoma

Author

Chuah, Khoon Leong, Yap, Wai Ming, Tan, Hong Wui, and Koong, Heng Nung

Subjects
Adenocarcinoma -- Diagnosis, Adenocarcinoma -- Case studies, CT imaging -- Usage, Biopsy -- Usage
Published
2006

47. Outcome after curative resection of large (>or=10 cm) gastric gastrointestinal stromal tumors: how frequent is adjacent organ involvement and is concomitant distal pancreatectomy necessary?

Author

Goh, Brian K. P., Chow, Pierce K. H., Kesavan, Sittampalam M., Yap, Wai-Ming, Chung, Yaw-Fui A., and Wong, Wai-Keong

Subjects
CURATIVE medicine, STOMACH tumors, GASTROINTESTINAL tumors, PANCREATECTOMY, STOMACH surgery, CANCER invasiveness, CHI-squared test, GASTRECTOMY, IMMUNOHISTOCHEMISTRY, METASTASIS, NONPARAMETRIC statistics, PANCREATIC diseases, PROGNOSIS, SURGICAL complications, SURVIVAL, TREATMENT effectiveness, PROPORTIONAL hazards models, RETROSPECTIVE studies
Abstract

Introduction: Complete tumor resection with clear margins including adjacent organs is the treatment of choice for gastrointestinal stromal tumors (GISTs). However, true tumor invasion of adjacent organs has been reported to be rare. Concomitant distal pancreatectomy (DP) for suspected tumor infiltration is not infrequently performed during resection of large gastric GISTs. This study aims to determine the true frequency of adjacent organ involvement by large gastric GISTs with particular attention to the pancreas and compares the outcome after curative resection with and without a concomitant DP in order to determine if DP is truly necessary.Methods: A retrospective review of 37 patients who underwent curative resection of large (>or=10 cm) gastric GISTs was conducted.Results: Wedge resections were performed in 22, partial gastectomies in nine, and total gastrectomies in six patients. The median operative time was 180 min (range, 60-330 min), and the patients had a median postoperative stay of 8 days (range, 4-29 days). Overall, there were eight (22%) morbidities including two (5%) mortalities. Nineteen (51%) had concomitant adjacent organ resection, and these included 15 (41%) DPs with splenectomies. Direct organ invasion was demonstrated in 5/19 patients (26%) and 7/30 organs (23%) resected. Only 1/15 (6.7%) DP specimens demonstrated tumor infiltration. Comparison between the patients with and without a concomitant DP demonstrated that performance of a DP was associated with a longer operation time [225 min (range, 105-305 min) vs 158 min (60-330 min), P=.002)], increased postoperative stay [9 days (range, 7-29 days) vs 7.5 days (4-19 days), P=.042], and increased postoperative morbidity [6 (40%) vs 2 (9%), P=.025]. The DP cohort also had a statistically significant poorer 5-year recurrence free survival (22% vs 60%, P=.017).Conclusion: Although adjacent organ involvement is not uncommon with large gastric GISTs, concomitant DP is usually unnecessary as direct pancreatic invasion is rare. Furthermore, concomitant DP with splenectomy is associated with an increase in postoperative morbidity. [ABSTRACT FROM AUTHOR]

Published
2010
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50. Test and teach. An uncommon but distinctive breast lesion. Diagnosis: Cystic hypersecretory lesion associated with pregnancy-like hyperplasia.

Author

Teo CH, Chuah KL, and Yap WM

Subjects
Aged, Calcinosis complications, Calcinosis pathology, Diabetes Mellitus, Female, Fibrocystic Breast Disease complications, Humans, Hyperlipidemias complications, Hyperplasia, Hypertension complications, Mammography, Myocardial Ischemia complications, Fibrocystic Breast Disease pathology
Published
2008
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