6,010 results on '"Yao, Yang"'
Search Results
2. MHAD: Multimodal Home Activity Dataset with Multi-Angle Videos and Synchronized Physiological Signals
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Yu, Lei, Fei, Jintao, Liu, Xinyi, Yao, Yang, Zhao, Jun, Wang, Guoxin, and Li, Xin
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Multimedia - Abstract
Video-based physiology, exemplified by remote photoplethysmography (rPPG), extracts physiological signals such as pulse and respiration by analyzing subtle changes in video recordings. This non-contact, real-time monitoring method holds great potential for home settings. Despite the valuable contributions of public benchmark datasets to this technology, there is currently no dataset specifically designed for passive home monitoring. Existing datasets are often limited to close-up, static, frontal recordings and typically include only 1-2 physiological signals. To advance video-based physiology in real home settings, we introduce the MHAD dataset. It comprises 1,440 videos from 40 subjects, capturing 6 typical activities from 3 angles in a real home environment. Additionally, 5 physiological signals were recorded, making it a comprehensive video-based physiology dataset. MHAD is compatible with the rPPG-toolbox and has been validated using several unsupervised and supervised methods. Our dataset is publicly available at https://github.com/jdh-algo/MHAD-Dataset.
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- 2024
3. Qwen2 Technical Report
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Yang, An, Yang, Baosong, Hui, Binyuan, Zheng, Bo, Yu, Bowen, Zhou, Chang, Li, Chengpeng, Li, Chengyuan, Liu, Dayiheng, Huang, Fei, Dong, Guanting, Wei, Haoran, Lin, Huan, Tang, Jialong, Wang, Jialin, Yang, Jian, Tu, Jianhong, Zhang, Jianwei, Ma, Jianxin, Yang, Jianxin, Xu, Jin, Zhou, Jingren, Bai, Jinze, He, Jinzheng, Lin, Junyang, Dang, Kai, Lu, Keming, Chen, Keqin, Yang, Kexin, Li, Mei, Xue, Mingfeng, Ni, Na, Zhang, Pei, Wang, Peng, Peng, Ru, Men, Rui, Gao, Ruize, Lin, Runji, Wang, Shijie, Bai, Shuai, Tan, Sinan, Zhu, Tianhang, Li, Tianhao, Liu, Tianyu, Ge, Wenbin, Deng, Xiaodong, Zhou, Xiaohuan, Ren, Xingzhang, Zhang, Xinyu, Wei, Xipin, Ren, Xuancheng, Liu, Xuejing, Fan, Yang, Yao, Yang, Zhang, Yichang, Wan, Yu, Chu, Yunfei, Liu, Yuqiong, Cui, Zeyu, Zhang, Zhenru, Guo, Zhifang, and Fan, Zhihao
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
This report introduces the Qwen2 series, the latest addition to our large language models and large multimodal models. We release a comprehensive suite of foundational and instruction-tuned language models, encompassing a parameter range from 0.5 to 72 billion, featuring dense models and a Mixture-of-Experts model. Qwen2 surpasses most prior open-weight models, including its predecessor Qwen1.5, and exhibits competitive performance relative to proprietary models across diverse benchmarks on language understanding, generation, multilingual proficiency, coding, mathematics, and reasoning. The flagship model, Qwen2-72B, showcases remarkable performance: 84.2 on MMLU, 37.9 on GPQA, 64.6 on HumanEval, 89.5 on GSM8K, and 82.4 on BBH as a base language model. The instruction-tuned variant, Qwen2-72B-Instruct, attains 9.1 on MT-Bench, 48.1 on Arena-Hard, and 35.7 on LiveCodeBench. Moreover, Qwen2 demonstrates robust multilingual capabilities, proficient in approximately 30 languages, spanning English, Chinese, Spanish, French, German, Arabic, Russian, Korean, Japanese, Thai, Vietnamese, and more, underscoring its versatility and global reach. To foster community innovation and accessibility, we have made the Qwen2 model weights openly available on Hugging Face and ModelScope, and the supplementary materials including example code on GitHub. These platforms also include resources for quantization, fine-tuning, and deployment, facilitating a wide range of applications and research endeavors., Comment: 26 pages, 1 figure
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- 2024
4. Exploring the Potential of Large Language Models in Graph Generation
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Yao, Yang, Wang, Xin, Zhang, Zeyang, Qin, Yijian, Zhang, Ziwei, Chu, Xu, Yang, Yuekui, Zhu, Wenwu, and Mei, Hong
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Quantitative Biology - Biomolecules - Abstract
Large language models (LLMs) have achieved great success in many fields, and recent works have studied exploring LLMs for graph discriminative tasks such as node classification. However, the abilities of LLMs for graph generation remain unexplored in the literature. Graph generation requires the LLM to generate graphs with given properties, which has valuable real-world applications such as drug discovery, while tends to be more challenging. In this paper, we propose LLM4GraphGen to explore the ability of LLMs for graph generation with systematical task designs and extensive experiments. Specifically, we propose several tasks tailored with comprehensive experiments to address key questions regarding LLMs' understanding of different graph structure rules, their ability to capture structural type distributions, and their utilization of domain knowledge for property-based graph generation. Our evaluations demonstrate that LLMs, particularly GPT-4, exhibit preliminary abilities in graph generation tasks, including rule-based and distribution-based generation. We also observe that popular prompting methods, such as few-shot and chain-of-thought prompting, do not consistently enhance performance. Besides, LLMs show potential in generating molecules with specific properties. These findings may serve as foundations for designing good LLMs based models for graph generation and provide valuable insights and further research.
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- 2024
5. Variation of All-Cause Mortality with Fat-Free Mass Index (FFMI) and Fat Mass Index (FMI) in Individuals with Asthma: Results from the NHANES Database Retrospective Cohort Study
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Chen, Jing, Cheng, Zihe, Yao, Yang, and Wang, Shengyu
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- 2024
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6. Quantitative contributions of climate change and human activities to vegetation dynamics in the Zoige Plateau from 2001 to 2020
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Gao, Bing, Liu, Enqin, Yang, Yang, Yang, Man, Yao, Yang, Guan, Lei, and Feng, Yiwen
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- 2024
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7. Changes in systemic immune-inflammation index (SII) predict the prognosis of patients with hepatitis B-related hepatocellular carcinoma treated with lenvatinib plus PD-1 inhibitors
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Yao, Yang, Zhang, Minyue, Liu, Di, Liu, Xiaoni, Li, Quanwei, and Wang, Xiaojun
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- 2024
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8. Rolling V-groove microstructures on glass using a modified PDMS mold
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Hsu, Ming-Huai, Tsai, Yao-Yang, Gao, Jhao-Hong, and Yang, Sen-Yeu
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- 2024
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9. Qwen Technical Report
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Bai, Jinze, Bai, Shuai, Chu, Yunfei, Cui, Zeyu, Dang, Kai, Deng, Xiaodong, Fan, Yang, Ge, Wenbin, Han, Yu, Huang, Fei, Hui, Binyuan, Ji, Luo, Li, Mei, Lin, Junyang, Lin, Runji, Liu, Dayiheng, Liu, Gao, Lu, Chengqiang, Lu, Keming, Ma, Jianxin, Men, Rui, Ren, Xingzhang, Ren, Xuancheng, Tan, Chuanqi, Tan, Sinan, Tu, Jianhong, Wang, Peng, Wang, Shijie, Wang, Wei, Wu, Shengguang, Xu, Benfeng, Xu, Jin, Yang, An, Yang, Hao, Yang, Jian, Yang, Shusheng, Yao, Yang, Yu, Bowen, Yuan, Hongyi, Yuan, Zheng, Zhang, Jianwei, Zhang, Xingxuan, Zhang, Yichang, Zhang, Zhenru, Zhou, Chang, Zhou, Jingren, Zhou, Xiaohuan, and Zhu, Tianhang
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Computer Science - Computation and Language - Abstract
Large language models (LLMs) have revolutionized the field of artificial intelligence, enabling natural language processing tasks that were previously thought to be exclusive to humans. In this work, we introduce Qwen, the first installment of our large language model series. Qwen is a comprehensive language model series that encompasses distinct models with varying parameter counts. It includes Qwen, the base pretrained language models, and Qwen-Chat, the chat models finetuned with human alignment techniques. The base language models consistently demonstrate superior performance across a multitude of downstream tasks, and the chat models, particularly those trained using Reinforcement Learning from Human Feedback (RLHF), are highly competitive. The chat models possess advanced tool-use and planning capabilities for creating agent applications, showcasing impressive performance even when compared to bigger models on complex tasks like utilizing a code interpreter. Furthermore, we have developed coding-specialized models, Code-Qwen and Code-Qwen-Chat, as well as mathematics-focused models, Math-Qwen-Chat, which are built upon base language models. These models demonstrate significantly improved performance in comparison with open-source models, and slightly fall behind the proprietary models., Comment: 59 pages, 5 figures
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- 2023
10. Efficacy and safety of immune checkpoint inhibitors in solid tumor patients combined with chronic coronary syndromes or its risk factor: a nationwide multicenter cohort study
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Liu, Chao, Ruan, Yuli, Huang, Rui, Fang, Lin, Wu, Tong, Lv, Ying, Cui, Luying, Liao, Yuanyu, Wang, Bojun, Chen, Zhuo, Su, Dan, Ma, Yue, Han, Shuling, Guan, Xin, Cui, Jie, Yao, Yang, Wang, Yao, Wang, Mengmeng, Liu, Ruiqi, and Zhang, Yanqiao
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- 2024
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11. The association of psychological and trauma-related factors with biological and facial aging acceleration: evidence from the UK Biobank
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Junren Wang, Xin Han, Yao Yang, Yu Zeng, Yuanyuan Qu, Huazhen Yang, Jie Song, Changjian Qiu, and Huan Song
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Psychological factors ,Trauma experience ,Biological aging acceleration ,Facial aging acceleration ,Length of telomeres ,Medicine - Abstract
Abstract Background Psychological and trauma-related factors are associated with many diseases and mortality. However, a comprehensive assessment of the association between psycho-trauma exposures and aging acceleration is currently lacking. Methods Using data from 332,359 UK Biobank participants, we calculated biological aging acceleration, indexed by the presence of leukocyte telomere length (LTL) deviation (i.e., the difference between genetically determined and observed LTL > 0). The acceleration of facial aging (i.e., looking older than the chronological age) was assessed using a self-report question. Then, we estimated the associations of each psycho-trauma factor with biological and facial aging acceleration, using logistic regression models adjusted for multiple important covariates. Furthermore, restricted to 99,180 participants with complete psychological and trauma-related data, we identified clusters of individuals with distinct psycho-trauma patterns using the latent class analysis method and assessed their associations with aging acceleration using similar models. Results We observed most of the studied psycho-trauma factors were associated with biological and facial aging acceleration. Compared to the “Absence of trauma and psychopathology” cluster, the “adverse childhood experiences (ACEs) with psychopathology” cluster showed strong associations with those aging measurements (odds ratio [OR] = 1.13 [1.05 − 1.23] for biological and 1.52 [1.18 − 1.95] for facial aging acceleration), while no such association was observed for the “ACEs without psychopathology” cluster (1.04 [0.99 − 1.09] and 1.02 [0.84 − 1.24]. Conclusions Our study demonstrated significant associations of psycho-trauma factors with both biological and facial aging acceleration. The differential aging consequences observed among ACEs exposed individuals with and without psychopathology prompt interventions aimed to improve individuals’ psychological resilience to prevent aging acceleration.
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- 2024
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12. Magnesium-based biomaterials for coordinated tissue repair: A comprehensive overview of design strategies, advantages, and challenges
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Yuan Chen, Siming Zhang, Jiaxiang Bai, Yao Yang, Yingjie Wang, Yanling Zhou, Wei Jiang, Junjie Wang, Junchen Zhu, Chen Zhu, and Xianzuo Zhang
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Magnesium-based biomaterials ,Design strategies ,Functional properties ,Clinical applications ,Challenges ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Magnesium-based biomaterials (MBMs) are one of the most promising materials for tissue engineering due to their unique mechanical properties and excellent functional properties. This review describes the development, advantages, and challenges of MBMs for biomedical applications, especially for tissue repair and regeneration. The history of the use of MBMs from the beginning of the 20th century is traced, and the transformative advances in contemporary applications of MBMs in areas such as orthopedics and cardiovascular surgery are emphasized. The review also provides insight into the signaling pathways affected by MBMs, such as the PI3K/Akt and RANKL/RANK/OPG pathways, which are critical for osteogenesis and angiogenesis. The review advocates that future research should focus on optimizing alloy compositions, surface modification and exploring innovative technologies such as 3D printing to improve the efficacy of MBMs in complex tissue repair. The potential of MBMs to tissue engineering and regenerative medicine is significant, urging further exploration and interdisciplinary collaboration to maximize their therapeutic effects.
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- 2024
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13. Spinal metastases from non-small cell lung cancer: Is surgical extent enough by following suggestions of the Tomita and Tokuhashi scores?
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An-Ping Huang, Ching-Yao Yang, Furen Xiao, Shih-Hung Yang, Chang-Mu Chen, Dar-Ming Lai, and Fon-Yih Tsuang
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Lung cancer ,Prognosis ,Spinal metastases ,Tokuhashi score ,Tomita score ,Surgery ,RD1-811 - Abstract
Background/objective: The Tomita, revised Tokuhashi and Tokuhashi lung scores are commonly used tools to predict the survival of patients with spinal metastases and to guide decisions regarding surgical treatment. These prognostic scores, however, tend to underestimate the prognosis of patients with lung cancer. We examined surgical outcome and hopefully provide a more accurate reference for management. Methods: The consistency between predicted and actual survival was examined using the Tomita and Tokuhashi scores. Various factors that may influence survival were analyzed. Primary outcomes were overall survival (OS) and progression-free survival (PFS), defined as the ambulatory time after the initial surgery. Secondary outcomes included reoperation events, blood loss, and hospitalization days. Results: One hundred seventy-two patients were enrolled. Correct survival predictions were made for 28%, 42%, and 56% with the Tomita, revised Tokuhashi, and Tokuhashi lung scores, respectively. The Tokuhashi lung scores underestimated OS by 35%–40%. Body mass index ≥20, systemic treatment-naïve, good general condition, the use of denosumab, and adenocarcinoma were found to positively affect OS and PFS. There was no significant difference between palliative decompression and excisional surgery regarding OS and PFS. Conclusion: Patients with spinal metastases from lung cancer had better prognosis than that predicted by the Tomita and Tokuhashi scores. Spine surgeons should acknowledge this discrepancy and treat these patients with at least the aggressiveness suggested. Patients with adenocarcinoma, amenable to target therapy, denosumab, good general condition, systemic treatment-naïve are better candidates for surgery. Those with cachexic status and unresectable visceral metastases are worse candidates.
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- 2024
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14. The Relationship between Mathematics Self-Efficacy and Mathematics Achievement: Multilevel Analysis with NAEP 2019
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Yao Yang, Yukiko Maeda, and Marcia Gentry
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Background: This empirical study aims to investigate the association between mathematics self-efficacy and mathematics achievement gaps among students in Grades 4, 8, and 12, utilizing data from the 2019 National Assessment of Educational Progress (NAEP). The study also considers student-level (e.g., mathematics self-efficacy, gender, race/ethnicity) and school-level (e.g., school location, proportion of underrepresented students) demographics to provide a comprehensive analysis of the factors contributing to mathematics achievement gaps. Methods: A two-level cross-sectional multilevel modeling approach was employed to analyze the variance in mathematics achievement, partitioning it into within- and between-school components. This approach allowed for an examination of association between mathematics self-efficacy and achievement gaps while considering various student and school characteristics. The rationale behind this methodology lies in its ability to capture the hierarchical nature of educational data and provide a nuanced understanding of the factors associated with mathematics achievement. Results: The analysis of the NAEP data revealed substantial variability in mathematics achievement across schools in the United States at all grade levels. Furthermore, mathematics self-efficacy emerged as a robust predictor of students' mathematics achievement, exhibiting significant effect sizes for Grades 4, 8, and 12. Remarkably, when students' mathematics self-efficacy was held constant, the mathematics achievement gaps among different student subgroups by gender, race/ethnicity, ELL, IEP, NSLP status narrowed, highlighting the importance of self-efficacy in addressing these disparities. The study also identified the presence of significant school contextual effects, further emphasizing the role of the educational environment in shaping mathematics achievement. Conclusions: This study underscores the critical role of mathematics self-efficacy in influencing mathematics achievement gaps among students. By acknowledging the association between self-efficacy beliefs and mathematics achievement, policymakers and educators can develop targeted interventions to enhance students' confidence and motivation in mathematics, ultimately promoting equitable educational outcomes. The findings also emphasize the significance of school-level factors, calling for comprehensive approaches that consider both individual and contextual factors in narrowing achievement gaps. The implications of adopting a self-efficacy perspective to address mathematics achievement gaps extend to educational policy, curriculum development, and instructional practices, ultimately fostering more inclusive and effective mathematics education for all students.
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- 2024
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15. A two-pronged approach to inhibit ferroptosis of MSCs caused by the iron overload in postmenopausal osteoporosis and promote osseointegration of titanium implant
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Yulu Yang, Xianhui Zhang, Yao Yang, Pengfei Gao, Wuzhe Fan, Tao Zheng, Weihu Yang, Yu Tang, and Kaiyong Cai
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Postmenopausal osteoporosis ,Iron overload ,Ferroptosis ,Caffeic acid nanosphere ,Ti implant ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biology (General) ,QH301-705.5 - Abstract
Postmenopausal osteoporosis (PMOP) is a prevalent condition among elderly women. After menopause, women exhibit decreased iron excretion, which is prone to osteoporosis. To design a specific titanium implant for PMOP, we first analyze miRNAs and DNA characteristics of postmenopausal patients with and without osteoporosis. The results indicate that iron overload disrupts iron homeostasis in the pathogenesis of PMOP. Further experiments confirm that iron overload can cause lipid peroxidation and ferroptosis of MSCs, thus breaking bone homeostasis. Based on the findings above, we have designed a novel Ti implant coated with nanospheres of caffeic acid (CA) and deferoxamine (DFO). CA can bind on the Ti surface through the two adjacent phenolic hydroxyls and polymerize into polycaffeic acid (PCA) dimer, as well as the PCA nanospheres with the repetitive 1,4-benzodioxan units. DFO was grafted with PCA through borate ester bonds. The experimental results showed that modified Ti can inhibit the ferroptosis of MSCs in the pathological environment of PMOP and promote osseointegration in two main ways. Firstly, DFO was released under high oxidative stress, chelating with excess iron and decreasing the labile iron pool in MSCs. Meanwhile, CA and DFO activated the KEAP1/NRF2/HMOX1 pathway in MSCs and reduced the level of intracellular lipid peroxidation. So, the ferroptosis of MSCs is inhibited by promoting the SLC7A11/GSH/GPX4 pathway. Furthermore, the remained CA coating on the Ti surface could reduce the extracellular oxidative stress and glutathione level. This study offers a novel inspiration for the specific design of Ti implants in the treatment of PMOP.
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- 2024
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16. The UTUH model: a time-dependent unified hardening constitutive model for unsaturated soils
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Zhao, Runkang, Zhou, Annan, and Yao, Yang-Ping
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- 2024
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17. A Chinese Way of Democratisation?
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Yao, Yang
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- 2010
18. Prognostic and therapeutic value of the Eph/Ephrin signaling pathway in pancreatic cancer explored based on bioinformatics
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Jifeng Liu, Qihang Yuan, Xu Chen, Yao Yang, Tong Xie, Yunshu Zhang, Bing Qi, Shuang Li, and Dong Shang
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Eph/ephrin signaling pathway ,Pancreatic cancer ,Prognosis biomarkers ,Molecular classification ,Chemotherapy sensitivity ,Medicine ,Science - Abstract
Abstract Pancreatic cancer (PC) is one of the most common malignant tumors of the digestive tract and has a very high mortality rate worldwide. Different PC patients may respond differently to therapy and develop therapeutic resistance due to the complexity and variety of the tumor microenvironment. The Eph/ephrin signaling pathway is extensively involved in tumor-related biological functions. However, the key function of the Eph/ephrin signaling pathway in PC has not been fully elucidated. We first explored a pan-cancer overview of Eph/ephrin signaling pathway genes (EPGs). Then we grouped the PC patients into 3 subgroups based on EPG expression levels. Significantly different prognoses and tumor immune microenvironments between different subtypes further validate Eph/ephrin's important role in the pathophysiology of PC. Additionally, we estimated the IC50 values for several commonly used molecularly targeted drugs used to treat PC in the three clusters, which could help patients receive a more personalized treatment plan. Following a progressive screening of optimal genes, we established a prognostic signature and validated it in internal and external test sets. The receiver operating characteristic (ROC) curves of our model exhibited great predictive performance. Meanwhile, we further validated the results through qRT-PCR and immunohistochemistry. Overall, this research provides fresh clues on the prognosis and therapy of PC as well as the theoretical groundwork for future Eph/ephrin signaling pathway research.
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- 2024
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19. Innovative graph neural network approach for predicting soil heavy metal pollution in the Pearl River Basin, China
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Yannan Zha and Yao Yang
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Heavy metal distribution prediction ,Graph neural network ,Soil pollution ,Geographic information ,Medicine ,Science - Abstract
Abstract Predicting soil heavy metal (HM) content is crucial for monitoring soil quality and ensuring ecological health. However, existing methods often neglect the spatial dependency of data. To address this gap, our study introduces a novel graph neural network (GNN) model, Multi-Scale Attention-based Graph Neural Network for Heavy Metal Prediction (MSA-GNN-HMP). The model integrates multi-scale graph convolutional network (MS-GCN) and attention-based GNN (AGNN) to capture spatial relationships. Using surface soil samples from the Pearl River Basin, we evaluate the MSA-GNN-HMP model against four other models. The experimental results show that the MSA-GNN-HMP model has the best predictive performance for Cd and Pb, with a coefficient of determination (R2) of 0.841 for Cd and 0.886 for Pb, and the lowest mean absolute error (MAE) of 0.403 mg kg−1 for Cd and 0.670 mg kg−1 for Pb, as well as the lowest root mean square error (RMSE) of 0.563 mg kg−1for Cd and 0.898 mg kg−1 for Pb. In feature importance analysis, latitude and longitude emerged as key factors influencing the heavy metal content. The spatial distribution prediction trend of heavy metal elements by different prediction methods is basically consistent, with the high-value areas of Cd and Pb respectively distributed in the northwest and northeast of the basin center. However, the MSA-GNN-HMP model demonstrates superior detail representation in spatial prediction. MSA-GNN-HMP model has excellent spatial information representation capabilities and can more accurately predict heavy metal content and spatial distribution, providing a new theoretical basis for monitoring, assessing, and managing soil pollution.
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- 2024
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20. Survival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study
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Hui-Jen Tsai, Yan-Shen Shan, Ching-Yao Yang, Chin-Fu Hsiao, Chung-Hsin Tsai, Chuan-Cheng Wang, Ming-Tsan Lin, Chun-Fu Ting, De-Chuan Chan, Te-Hung Chen, Chueh-Chuan Yen, Yen-Yang Chen, Hsuan-Yu Lin, Ta-Sen Yeh, Ching-Liang Ho, Tze-Yu Shieh, Li-Yaun Bai, Jun-Te Hsu, I-Shu Chen, Li-Tzong Chen, Chun-Nan Yeh, and Taiwan Cooperative Oncology Group (TCOG) GIST Study Group
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Gastrointestinal stromal tumor ,Metastatic ,Recurrent ,Tyrosine kinase inhibitor ,Registry study ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Most gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has significantly improved the survival of patients with GISTs. We aimed to evaluate the clinical outcome of advanced or recurrent GIST patients in Taiwan. Methods Patients diagnosed between 2010 and 2020 were enrolled. The collected data included baseline characteristics, treatment pattern, treatment outcome, genetic aberrations and survival status. Progression-free survival (PFS) and overall survival (OS) were analyzed and plotted with the Kaplan–Meier method. Cox regression analysis was used to analyze the prognostic factors of survival. Results A total of 224 patients with advanced or recurrent GISTs treated with TKIs were enrolled. All patients received imatinib treatment. Ninety-three and 42 patients received sunitinib and regorafenib treatment, respectively. The 48-month PFS and OS rates for patients treated with imatinib were 50.5% and 79.5%, respectively. c-KIT exon 9 and PDGFRA mutations were prognostic factors for a poor PFS and PDGFRA mutation was a prognostic factor for a poor OS in patients treated with imatinib in multivariate Cox regression analysis. The median PFS of patients who received sunitinib treatment was 12.76 months (95% confidence interval (CI), 11.01–14.52). Patients with c-KIT exon 9 mutations had a longer PFS than those with other genetic aberrations. The median PFS of patients treated with regorafenib was 7.14 months (95% CI, 3.39–10.89). Conclusions We present real-world clinical outcomes for advanced GIST patients treated with TKIs and identify mutational status as an independent prognostic factor for patient survival.
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- 2024
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21. Circ_0004851 regulates the molecular mechanism of miR-296-3p/FGF11 in the influence of high iodine on PTC
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Jing-jing Li, Zi-xuan Ru, Xu Yang, Jing-xue Sun, Yan-mei-zhi Wu, Xiao-yao Yang, Bo-yu Hou, Bing Xue, Chao Ding, and Hong Qiao
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Iodine ,PTC ,Circ_0004851 ,miR-296-3p ,FGF11 ,Tumor development ,Medicine - Abstract
Abstract The prevalence of papillary thyroid cancer (PTC) has been rising in recent years. Despite its relatively low mortality, PTC frequently metastasizes to lymph nodes and often recurs, posing significant health and economic burdens. The role of iodine in the pathogenesis and advancement of thyroid cancer remains poorly understood. Circular RNAs (circRNAs) are recognized to function as competing endogenous RNAs (ceRNAs) that modulate gene expression and play a role in various cancer stages. Consequently, this research aimed to elucidate the mechanism by which circRNA influences the impact of iodine on PTC. Our research indicates that high iodine levels can exacerbate the malignancy of PTC via the circ_0004851/miR-296-3p/FGF11 axis. These insights into iodine’s biological role in PTC and the association of circRNA with the disease could pave the way for novel biomarkers and potentially effective therapeutic strategies to mitigate PTC progression.
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- 2024
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22. Project case of taurine production wastewater treatment
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PENG Jiwei, CHEN Hao, XIAO Lei, HE Jinfeng, and YAO Yang
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taurine production wastewater ,rear anoxia tank ,sulphide ,ammonia nitrogen ,tapered aeration ,Environmental technology. Sanitary engineering ,TD1-1066 - Abstract
With the wastewater treatment project of a taurine production enterprise in Hubei as a case study, this paper analyzed the production process and wastewater quality characteristics of the enterprise, the targeted treatment process of “hydrolysis acidification+pre anoxic+aerobic biochemistry+post anoxic+secondary sedimentation” was adopted. When the average influent COD, ammonia nitrogen, and total nitrogen were 956.8, 50.6, 99.1 mg/L, respectively, the average effluent COD, ammonia nitrogen, and TN were 73.6, 1.6, 12.2 mg/L, respectively, with the average removal rates could reach 92.3%, 96.9%, and 87.7%, respectively. The effluent water quality was stable and meet the limits of water pollutants for newly built enterprises in the Chemical Synthesis Pharmaceutical Industry Water Pollutant Discharge Standard(GB 21904-2008). By adopting tapered aeration and fan frequency conversion control, energy consumption was significantly reduced, and the operating cost was 1.60 CNY/m3.
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- 2024
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23. DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure
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Mingjing Yan, Junpeng Gao, Ming Lan, Que Wang, Yuan Cao, Yuxuan Zheng, Yao Yang, Wenlin Li, Xiaoxue Yu, Xiuqing Huang, Lin Dou, Bing Liu, Junmeng Liu, Hongqiang Cheng, Kunfu Ouyang, Kun Xu, Shenghui Sun, Jin Liu, Weiqing Tang, Xiyue Zhang, Yong Man, Liang Sun, Jianping Cai, Qing He, Fuchou Tang, Jian Li, and Tao Shen
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Medicine ,Biology (General) ,QH301-705.5 - Abstract
Abstract DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understood. We generated cardiomyocyte-specific Ddx17-knockout mice (Ddx17-cKO), cardiomyocyte-specific Ddx17 transgenic mice (Ddx17-Tg), and various models of cardiomyocyte injury and heart failure (HF). DDX17 is downregulated in the myocardium of mouse models of heart failure and cardiomyocyte injury. Cardiomyocyte-specific knockout of Ddx17 promotes autophagic flux blockage and cardiomyocyte apoptosis, leading to progressive cardiac dysfunction, maladaptive remodeling and progression to heart failure. Restoration of DDX17 expression in cardiomyocytes protects cardiac function under pathological conditions. Further studies showed that DDX17 can bind to the transcriptional repressor B-cell lymphoma 6 (BCL6) and inhibit the expression of dynamin-related protein 1 (DRP1). When DDX17 expression is reduced, transcriptional repression of BCL6 is attenuated, leading to increased DRP1 expression and mitochondrial fission, which in turn leads to impaired mitochondrial homeostasis and heart failure. We also investigated the correlation of DDX17 expression with cardiac function and DRP1 expression in myocardial biopsy samples from patients with heart failure. These findings suggest that DDX17 protects cardiac function by promoting mitochondrial homeostasis through the BCL6-DRP1 pathway in heart failure.
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- 2024
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24. Infinite series involving harmonic numbers and reciprocal of binomial coefficients
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Kwang-Wu Chen and Fu-Yao Yang
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multiple zeta values ,harmonic numbers ,binomial coefficients ,yamamoto's integral ,2-poset ,Mathematics ,QA1-939 - Abstract
Yamamoto's integral was the integral associated with 2-posets, which was first introduced by Yamamoto. In this paper, we obtained the values of infinite series involving harmonic numbers and reciprocal of binomial coefficients by using some techniques of Yamamoto's integral. We determine the value of infinite series of the form: $ \sum\limits_{m_1,\ldots,m_n,\ell_1,\ldots,\ell_k\geq 1}\frac{H_{m_1}^{(a_1)}\cdots H_{m_n}^{(a_n)}} {m_1^{b_1}\cdots m_n^{b_n}\ell_1^{c_1}\cdots\ell_k^{c_k} \binom{m_1+\cdots+m_n+\ell_1+\cdots+\ell_k}{\ell_k}}, $ in terms of a finite sum of multiple zeta values, for positive integers $ a_1, \ldots, a_n, b_1, \ldots, b_n, c_1, \ldots, c_k $.
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- 2024
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25. AODiMP‐TIR: Anti‐occlusion thermal infrared targets tracker based on SuperDiMP
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Shaoyang Ma, Yao Yang, and Gang Chen
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infrared imaging ,Kalman filters ,object tracking ,Photography ,TR1-1050 ,Computer software ,QA76.75-76.765 - Abstract
Abstract To address the issue of tracking drift and failures in thermal infrared (TIR) tracking tasks caused by target occlusion, this study proposes an anti‐occlusion TIR target tracker named AODiMP‐TIR. This approach involves an anti‐occlusion strategy that relies on target occlusion status determination and trajectory prediction. This enables the prediction of the target's current position when it is identified as occluded, ensuring swift recapture upon reappearance. A criterion is introduced for occlusion status determination based on the classification response map of SuperDiMP. Additionally, a trajectory mapping module designed to decouple target motion from camera motion is presented, enhancing the precision of trajectory prediction. Comparative experiments with other state‐of‐the‐art trackers are conducted on the large‐scale high‐diversity thermal infrared object tracking benchmark (LSOTB‐TIR), LSOTB‐TIR100, and thermal infrared pedestrian tracking benchmark (PTB‐TIR) datasets. The results indicate that the AODiMP‐TIR performs well across all three datasets, particularly exhibiting outstanding performance in occlusion sequences. Furthermore, ablation study experiments confirm the effectiveness of the anti‐occlusion strategy, occlusion determination criterion and trajectory mapping module.
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- 2024
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26. The relationship between mathematics self-efficacy and mathematics achievement: multilevel analysis with NAEP 2019
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Yao Yang, Yukiko Maeda, and Marcia Gentry
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NAEP ,Mathematics self-efficacy ,Mathematics achievement ,Achievement gap ,Education (General) ,L7-991 - Abstract
Abstract Background This empirical study aims to investigate the association between mathematics self-efficacy and mathematics achievement gaps among students in Grades 4, 8, and 12, utilizing data from the 2019 National Assessment of Educational Progress (NAEP). The study also considers student-level (e.g., mathematics self-efficacy, gender, race/ethnicity) and school-level (e.g., school location, proportion of underrepresented students) demographics to provide a comprehensive analysis of the factors contributing to mathematics achievement gaps. Methods A two-level cross-sectional multilevel modeling approach was employed to analyze the variance in mathematics achievement, partitioning it into within- and between-school components. This approach allowed for an examination of association between mathematics self-efficacy and achievement gaps while considering various student and school characteristics. The rationale behind this methodology lies in its ability to capture the hierarchical nature of educational data and provide a nuanced understanding of the factors associated with mathematics achievement. Results The analysis of the NAEP data revealed substantial variability in mathematics achievement across schools in the United States at all grade levels. Furthermore, mathematics self-efficacy emerged as a robust predictor of students' mathematics achievement, exhibiting significant effect sizes for Grades 4, 8, and 12. Remarkably, when students' mathematics self-efficacy was held constant, the mathematics achievement gaps among different student subgroups by gender, race/ethnicity, ELL, IEP, NSLP status narrowed, highlighting the importance of self-efficacy in addressing these disparities. The study also identified the presence of significant school contextual effects, further emphasizing the role of the educational environment in shaping mathematics achievement. Conclusions This study underscores the critical role of mathematics self-efficacy in influencing mathematics achievement gaps among students. By acknowledging the association between self-efficacy beliefs and mathematics achievement, policymakers and educators can develop targeted interventions to enhance students' confidence and motivation in mathematics, ultimately promoting equitable educational outcomes. The findings also emphasize the significance of school-level factors, calling for comprehensive approaches that consider both individual and contextual factors in narrowing achievement gaps. The implications of adopting a self-efficacy perspective to address mathematics achievement gaps extend to educational policy, curriculum development, and instructional practices, ultimately fostering more inclusive and effective mathematics education for all students.
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- 2024
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27. Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim
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Shi-Yan Feng, Na Jiang, Jia-Ying Yang, Lin-Yao Yang, Jiang-Chao Du, Xuan-Qin Chen, Dan Liu, Rong-Tao Li, and Jin-Dong Zhong
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Mosla chinensis Maxim ,Flavonoids ,Phenolic structure ,Anti-H1N1 virus activity ,Anti-inflammatory activity ,Botany ,QK1-989 - Abstract
Abstract Seven undescribed compounds, including three flavones (1–3), one phenylpropanoid (19), three monoaromatic hydrocarbons (27–29), were isolated from the twigs of Mosla chinensis Maxim together with twenty-eight known compounds. The structures were characterized by HRESIMS, 1D and 2D NMR, and ECD spectroscopic techniques. Compound 20 displayed the most significant activity against A/WSN/33/2009 (H1N1) virus (IC50 = 20.47 μM) compared to the positive control oseltamivir (IC50 = 6.85 µM). Further research on the anti-influenza mechanism showed that compound 20 could bind to H1N1 virus surface antigen HA1 and inhibit the early attachment stage of the virus. Furthermore, compounds 9, 22, 23, and 25 displayed moderate inhibitory effects on the NO expression in LPS inducing Raw 264.7 cells with IC50 values of 22.78, 20.47, 27.66, and 30.14 µM, respectively. Graphical Abstract
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- 2024
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28. Phytic acid as an eco-friendly phosphorus source in the synthesis of phosphorus-doped NiCo2O4 for supercapacitor electrodes
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Chun-Ying Chao, Hong-Fei Li, Pin-Jiang Li, Jia-Yao Yang, Li-Jun Wu, Hong-Wei Yue, and Hao Li
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NiCo2O4 ,Supercapacitors ,Heteroatom doping ,Phytic acid ,Electrochemical performance ,Technology - Abstract
This study explores the synthesis of nickel-cobalt bimetallic precursors using phytic acid (PA) as a phosphorus source and their application as supercapacitor electrodes. Through high-temperature annealing, these precursors were converted into phosphorus-doped nickel-cobalt bimetallic oxides (NCO) with certain defects. The morphologies and particle size of NCO can be easily adjusted by the amount of PA. Compared to the undoped nickel-cobalt bimetallic oxides, the phosphorus-doped materials exhibited significantly enhanced electrochemical activity and specific capacitance. The optimized electrode exhibits the highest specific capacitance of 1075 F·g−1 at a current density of 1 A·g−1. The asymmetric supercapacitor assembled together with activated carbon can deliver a relatively high energy density of 39.8 Wh·kg−1 at a power density of 696 W·kg−1. Additionally, this paper provides a detailed discussion on the impact of phosphorus doping on the performance of supercapacitor electrodes and the potential of PA as an eco-friendly phosphorus source in the synthesis of high-performance electrode materials.
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- 2024
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29. Pathogen detection by targeted next-generation sequencing test in adult hematological malignancies patients with suspected infections
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Jin-Hui Xu, Ya-Bin Cui, Li-Jie Wang, Hui-Jie Nan, Pei-Yao Yang, Yan-Liang Bai, and Ming-Yue Shi
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hematological malignancies ,infections ,targeted next-generation sequencing ,conventional microbiological tests ,pathogenic detection ,Medicine (General) ,R5-920 - Abstract
BackgroundInfections in patients with hematological malignancies (HM) are a significant cause of morbidity and mortality. Timely and effective empirical anti-infective treatment can reduce the infection-related mortality rate. Targeted next-generation sequencing (tNGS) offers a rapid diagnostic approach for identifying diverse pathogens in these patients. However, relevant research is still limited to adult patients with HM.MethodsWe conducted a retrospective analysis of adult HM patients admitted to our hospital from March 2023 to September 2023, focusing on their clinical characteristics and the results of both tNGS and conventional microbiological tests (CMTs). We evaluated the performance of tNGS and CMTs in pathogenic diagnosis and described the distribution characteristics of pathogens in adult HM patients with infections.ResultsThe study included 209 samples collected from 137 patients. Results showed that the overall pathogen detection rate differed significantly between tNGS and CMTs (60.3% vs. 24.4%, p
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- 2024
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30. The impact and risk factors for developing pneumogenic bacteremia in carbapenem-resistant Acinetobacter baumannii nosocomial pneumonia in the intensive care unit: A multicenter retrospective study
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Sheng-Huei Wang, Chi-Kang Teng, Ming-Cheng Chan, Kuang-Yao Yang, Chau-Chyun Sheu, Shinn-Jye Liang, Wei-Hsuan Huang, Jia-Yih Feng, Chia-Min Chen, Zi-Xeng Weng, and Chung-Kan Peng
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Carbapenem-resistant Acinetobacter baumannii ,Bacteremia ,Nosocomial pneumonia ,Risk factor ,Mortality ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objectives: This study analyzed the risk and impact of developing pneumogenic bacteremia in patients with CRAB nosocomial pneumonia in ICU. Methods: This is multicenter retrospective study. Clinical outcomes were compared between bacteremia and non-bacteremia group, and the risk factors for mortality and developing pneumogenic CRAB bacteremia were analyzed. Results: After patient recruitment, 164 cases were in the bacteremia group, and 519 cases were in the non-bacteremia group. The bacteremia group had 22.4 percentage of increase in-hospital mortality than the non-bacteremia group (68.3% vs 45.9%, P < 0.001). Multivariate analysis showed bacteremia was an independent risk factor for in-hospital mortality (aHR = 2.399, P < 0.001). A long time-interval between ICU admission and pneumonia onset was an independent risk factor for developing bacteremia (aOR = 1.040, P = < 0.001). Spearman's rank correlation analysis indicated a high correlation between the days from ICU admission to pneumonia onset and the days of ventilator use before pneumonia onset (correlation coefficient (ρ) = 0.777). Conclusions: In patients with CRAB nosocomial pneumonia, bacteremia increased the in-hospital mortality, and a longer interval from ICU admission to pneumonia onset was an independent risk factor for developing bacteremia, which was highly associated with the use of mechanical ventilation.
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- 2024
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31. Follistatin-respiratory connection predicting all-cause mortality among community-dwelling middle-to-old age individuals: Results from the I-Lan Longitudinal Study
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Hsiao-Chin Shen, Wei-Ju Lee, Chuan-Yen Sun, Wen-Kuang Yu, Wei-Chih Chen, Fei-Yuan Hsiao, Kuang-Yao Yang, and Liang-Kung Chen
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Pulmonary function ,Aging ,Follistatin ,Biomarkers ,Mortality ,Internal medicine ,RC31-1245 - Abstract
Objectives: The link between aging and pulmonary function decline is well-established, but the underlying mechanisms have yet to be fully revealed. Serum follistatin, a myokine implicated in muscle degeneration, may play a role in age-related pulmonary changes. This study aims to investigate the relationship between serum follistatin levels and pulmonary function decline in community-dwelling older adults, and evaluate their combined association with all-cause mortality. Research design and methods: This longitudinal cohort study utilized data from 751 participants aged ≥50 years in the I-Lan Longitudinal Aging Study between 2018−2019. Serum follistatin levels, spirometry results, demographic and clinical data were retrieved. Participants were stratified based on their follistatin levels. Survival curves and group comparisons based on follistatin levels and decline in peak expiratory flow (PEF) using Kaplan-Meier analysis and log-rank tests. Multivariate Cox proportional hazards models were further used to identify independent predictors of all-cause mortality during the 52-month follow-up. Results: Elevated follistatin levels significantly correlated with worse pulmonary function, particularly decreased PEF (p = 0.030). Kaplan–Meier analysis revealed the combination of elevated follistatin levels and decreased PEF was associated with increased risk of all-cause mortality (Log-rank p = 0.023). Cox proportional hazards models further identified that concurrent presence of higher follistatin levels and decreased PEF predicted higher risk of all-cause mortality (adjusted HR 3.58, 95% CI: 1.22–10.53, p = 0.020). Conclusion: Higher serum follistatin levels correlate with decreased pulmonary function, specifically PEF decline, in community-dwelling older adults. Furthermore, the coexistence of elevated follistatin levels and decreased PEF was associated with risk of all-cause mortality. Follistatin may serve as a biomarker for pulmonary aging and related adverse outcomes.
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- 2024
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32. Molecular detection of emerging porcine circovirus in Taiwan
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Yu Fan Hung, Po-Chen Liu, Ching-Hung Lin, Chao-Nan Lin, Hung-Yi Wu, Ming-Tang Chiou, Hung-Jen Liu, and Cheng-Yao Yang
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Porcine circovirus (PCV) ,PCV3 ,PCV4 ,Emerging disease ,phylogenetic analysis ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Porcine Circovirus type (PCV) 2 is an important pathogen that has been circulating worldwide and has cuased serious economic loss in pig industry. However, both PCV3 and PCV4 are newly emerging viruses. In Taiwan, PCV2 has been one of the critical pathogens in pig frams and PCV3 has been detected since 2016; however, the epidemiolog of PCV3 in Taiwan remains unclear and PCV4 has yet to be identified. Therefore, in order to detect the positive rate of PCV2, to investigate the epidemiolog of PCV3 in the pig farms, and to examine whether pigs were infected with PCV4 in Taiwan, a total of 128 samples from 46 clinical cases of pigs were collected from September 2020 to December 2021. The case detection rates were 54.3 % for PCV2, 43.5 % for PCV3, and 2.2 % for PCV4. The results suggested that the positivity rates for both PCV2 and PCV3 were still high in Taiwan. In addition, PCV3 was detected among cases from all 7 sampled counties and in 11 of the 16 sampling months, suggesting that PCV3 may lead to endemic pig disease in Taiwan. Surprisingly, the PCV4 was also detected, suggesting the first PCV4 case in Taiwan. The complete genomes derived from the identified PCV3 and PCV4 strains were subsequently sequenced followed by phylogenetic analysis. The results suggested that the 17 identified PCV3 strains could be divided into Taiwanese-like and Japanese-like strains. In addition, the amino acid residues at positions 27, 80, and 212 in the identified PCV4 cap protein were asparagine, isoleucine, and methionine, respectively, and thus the identified PCV4 was catalorized into clade PCV4b. Consequently, it is concluded that (i) the prevalence of PCV2 and PCV3 is still high in Taiwanese pigs, (ii) PCV3 has may be an endemic infection in Taiwan and can be classified into Japanese-like and Taiwanese-like strains, (iii) PCV4 was detected for the first time in Taiwanese pigs and can be classified into PCV4b. It remains unclear how PCV2, PCV3, and PCV4 were introduced to Taiwan, and thus continuous investigation of emerging pathogens in pigs is needed.
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- 2024
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33. Case report: intracranial lesions in a patient with anxiety and depression: tumor recurrence or radiation encephalopathy?
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Haiping You, Lin He, Zhibo Ouyang, Yao Yang, Shu Xie, Jiwei Zhou, Yun Zhang, and Jian Shi
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radiation encephalopathy ,anxiety disorders ,depressive disorders ,nasopharyngeal cancer ,radiotherapy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
PurposeRadiation encephalopathy (REP) is one of the most common complications of radiotherapy for malignant tumors of the head and neck. Symptoms usually appear months to years following radiotherapy, with headache, insomnia, and memory loss as the main clinical features. We report a patient who was admitted to the hospital with anxiety and depressive disorder and was eventually diagnosed with REP.Patients and methodsA 48-year-old patient who had undergone over 2 years of radiotherapy for nasopharyngeal carcinoma was admitted to the Department of Psychosomatic Medicine of our hospital because of recurrent fear, low mood, and waking up from dreams. Magnetic resonance imaging (MRI) revealed a mass in the left temporal lobe with a large peripheral edema. After multidisciplinary consultation, the possibility of tumor recurrence could not be excluded.ResultsResection of the lesioned brain tissue to obtain pathological tissue showed glial cell proliferation and small focal areas of degeneration and necrosis, which indicated that the lesions were inflammatory. Postoperative MRI showed no abnormal signal, and the patient’s condition improved.ConclusionNasopharyngeal carcinoma patients with a history of radiotherapy and symptoms of increased intracranial pressure and neurological damage should be examined for REP. Furthermore, patients may experience anxiety and depressive disorders as a result of temporal lobe damage caused by REP.
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- 2024
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34. The role of Clec11a in bone construction and remodeling
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Ke Xu, Rui-qi Huang, Ruiming Wen, Yao Yang, Yang Cheng, and Bo Chang
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Clec11a ,skeletal system ,bone construction ,bone remodeling ,exercise ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Bone is a dynamically active tissue whose health status is closely related to its construction and remodeling, and imbalances in bone homeostasis lead to a wide range of bone diseases. The sulfated glycoprotein C-type lectin structural domain family 11 member A (Clec11a) is a key factor in bone mass regulation that significantly promotes the osteogenic differentiation of bone marrow mesenchymal stem cells and osteoblasts and stimulates chondrocyte proliferation, thereby promoting longitudinal bone growth. More importantly, Clec11a has high therapeutic potential for treating various bone diseases and can enhance the therapeutic effects of the parathyroid hormone against osteoporosis. Clec11a is also involved in the stress/adaptive response of bone to exercise via mechanical stimulation of the cation channel Pieoz1. Clec11a plays an important role in promoting bone health and preventing bone disease and may represent a new target and novel drug for bone disease treatment. Therefore, this review aims to explore the role and possible mechanisms of Clec11a in the skeletal system, evaluate its value as a potential therapeutic target against bone diseases, and provide new ideas and strategies for basic research on Clec11a and preventing and treating bone disease.
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- 2024
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35. Point-Correlate Adversarial Transformer for Unsupervised Multivariate Time Series Anomaly Detection.
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Huan Li, Xiangjie Kong 0001, Guojiang Shen, Xiaoran Yan, Yao Yang, and Mario Collotta
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- 2024
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36. Adaptive Meta-Learning Probabilistic Inference Framework for Long Sequence Prediction.
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Jianping Zhu, Xin Guo, Yang Chen, Yao Yang, Wenbo Li, Bo Jin, and Fei Wu
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- 2024
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37. A double-sided PDMS mold for double-sided embossing by rollers
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Hsu, Ming-Huai, Tsai, Yao-Yang, He, Jyun-Wei, and Yang, Sen-Yeu
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- 2024
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38. Measurement of Critical Temperatures, Critical Pressures and Densities of Acetone–Water Solutions for Simulation
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Chen, Zhirong, Yao, Yang, Yuan, Shenfeng, and Yin, Hong
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- 2023
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39. A Systematic Workflow of Data Mining Confirms Widespread Occurrence of Antibiotic Contamination in Freshwater Reservoirs
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Guo, Zhao-Feng, Boeing, Wiebke J., Xu, Yao-Yang, Borgomeo, Edoardo, Liu, Dong, and Zhu, Yong-Guan
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- 2023
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40. Influence of vaccination on critical COVID-19 patients with acute respiratory failure: a retrospective cohort study
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Hsiao-Chin Shen, Jhong-Ru Huang, Chuan-Yen Sun, Ying-Ting Liao, Hung-Jui Ko, Chih-Jung Chang, Jia-Yih Feng, Yuh-Min Chen, Wei-Chih Chen, and Kuang-Yao Yang
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Acute Respiratory Failure ,Acute Respiratory Distress Syndrome ,Coronavirus Disease 2019 (COVID-19) ,COVID-19 Vaccines ,Virus Shedding ,Medicine - Abstract
Abstract Background Despite vaccines’ effectiveness in reducing COVID-19 infection rates and disease severity, their impact on critical patients presenting with acute respiratory failure is elusive. The aim of this study was to further investigate the influence of vaccination on mortality rates among severely ill COVID-19 patients experiencing acute respiratory failure. Methods This retrospective cohort study was carried out at a tertiary medical center in Taiwan. From April to September 2022, patients who tested positive for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through reverse transcription polymerase chain reaction (RT-PCR) and subsequently experienced acute respiratory failure were included in the study. Baseline characteristics, including vaccination history, along with information regarding critical illness and clinical outcomes, were gathered and compared between patients who received the vaccine and those who did not. Results A total of 215 patients with COVID-19 exhibiting acute respiratory failure, as confirmed via RT‒PCR, were included in the analysis. Of this cohort, sixty-six (30.7%) patients died within 28 days. Neither administration of the vaccine nor achievement of primary series vaccination status had a significantly different effect on 28 day mortality, number of viral shedding events, acute respiratory distress syndrome (ARDS) incidence or other clinical outcomes. Patients who received the booster vaccine and completed the primary series showed a tendency of increased 28 days of ventilator-free status, though this difference was not statistically significant (p = 0.815). Conclusions Vaccination status did not significantly influence mortality rates, the occurrence of ARDS, or the viral shedding duration in COVID-19 patients with acute respiratory failure.
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- 2024
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41. Study on the preservation effects of the amputated forelimb by machine perfusion at physiological temperature
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Sheng-Feng Chen, Bo-Yao Yang, Tie-Yuan Zhang, Xiang-Yu Song, Zhi-Bo Jia, Lei-Jia Chen, Meng-Yi Cui, Wen-Jing Xu, and Jiang Peng
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Traumatic amputation ,Machine perfusion ,Static cold storage ,Limb replantation ,Medicine (General) ,R5-920 - Abstract
Purpose: Ischemia and hypoxia are the main factors limiting limb replantation and transplantation. Static cold storage (SCS), a common preservation method for tissues and organs, can only prolong limb ischemia time to 4 – 6 h. The normothermic machine perfusion (NMP) is a promising method for the preservation of tissues and organs, which can extend the preservation time in vitro by providing continuous oxygen and nutrients. This study aimed to evaluate the difference in the efficacy of the 2 limb preservation methods. Methods: The 6 forelimbs from beagle dogs were divided into 2 groups. In the SCS group (n = 3), the limbs were preserved in a sterile refrigerator at 4 °C for 24 h, and in the NMP group (n = 3), the perfusate prepared with autologous blood was used for the oxygenated machine perfusion at physiological temperature for 24 h, and the solution was changed every 6 h. The effects of limb storage were evaluated by weight gain, perfusate biochemical analysis, enzyme-linked immunosorbent assay, and histological analysis. All statistical analyses and graphs were performed using GraphPad Prism 9.0 one-way or two-way analysis of variance. The p value of less than 0.05 was considered to indicate statistical significance. Results: In the NMP group, the weight gained percentage was 11.72% ± 4.06%; the hypoxia-inducible factor-1α contents showed no significant changes; the shape of muscle fibers was normal; the gap between muscle fibers slightly increased, showing the intercellular distance of (30.19 ± 2.83) μm; and the vascular α-smooth muscle actin (α-SMA) contents were lower than those in the normal blood vessels. The creatine kinase level in the perfusate of the NMP group increased from the beginning of perfusion, decreased after each perfusate change, and remained stable at the end of perfusion showing a peak level of 4097.6 U/L. The lactate dehydrogenase level of the NMP group increased near the end of perfusion and reached the peak level of 374.4 U/L. In the SCS group, the percentage of weight gain was 0.18% ± 0.10%, and the contents of hypoxia-inducible factor-1α increased gradually and reached the maximum level of (164.85 ± 20.75) pg/mL at the end of the experiment. The muscle fibers lost their normal shape and the gap between muscle fibers increased, showing an intercellular distance of (41.66 ± 5.38) μm. The contents of vascular α-SMA were much lower in the SCS group as compared to normal blood vessels. Conclusions: NMP caused lesser muscle damage and contained more vascular α-SMA as compared to SCS. This study demonstrated that NMP of the amputated limb with perfusate solution based on autologous blood could maintain the physiological activities of the limb for at least 24 h.
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- 2024
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42. Quantitative characteristics and influencing factors of Tibetan Buddhist religious space with monasteries as the carrier: a case study of U-Tsang, China
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Subin Fang, Yaolong Zhao, Xinxin Liu, and Yao Yang
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Tibetan Buddhist Monasteries ,Spatial distribution ,Religious space ,Influencing factors ,Tibetan regions ,Fine Arts ,Analytical chemistry ,QD71-142 - Abstract
Abstract Tibetan Buddhism has an inseparable connection with the spatial characteristics, development process, and human-natural environment of the Tibetan Plateau. This paper takes monasteries as carriers of Tibetan Buddhist culture in U-Tsang region which is one of the traditional geographical units of Tibet. Using geospatial analysis methods, this study explores the spatial quantification characteristics of Tibetan Buddhist monasteries and qualitatively and quantitatively analyzes the factors that influence the spatial distribution of monasteries. The results indicate that: (1) Political activities of human society influence the pattern of political power. Under the unique context of Tibetan theocracy system, the scope of political authority has a significant influence and affects the religious spatial pattern in the U-Tsang region throughout history. The distribution of monasteries in the U-Tsang region shows significant spatial differences at three sub-regional scales. (2) The religious spatial pattern in the U-Tsang is the result of the diverse interaction of human-natural factors. The results indirectly endorse that religious space is an inevitable product of the interaction between humans and the environment. (3) The religious spatial distribution patterns in the three major Tibetan regions have distinct characteristics, closely related to the superior conditions of their respective historical and geographical environments.
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- 2024
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43. Physiological responses to drought stress of three pine species and comparative transcriptome analysis of Pinus yunnanensis var. pygmaea
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Feng Xiao, Yang Zhao, Xiurong Wang, Xueyan Jian, and Yao Yang
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Pinus yunnanensis var. pygmaea ,Drought stress ,Rehydration ,PacBio ,Transcriptome ,WGCNA ,Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Abstract
Abstract Drought stress can significantly affect plant growth, development, and yield. Fewer comparative studies have been conducted between different species of pines, particularly involving Pinus yunnanensis var. pygmaea (P. pygmaea). In this study, the physiological indices, photosynthetic pigment and related antioxidant enzyme changes in needles from P. pygmaea, P. elliottii and P. massoniana under drought at 0, 7, 14, 21, 28 and 35 d, as well as 7 days after rehydration, were measured. The PacBio single-molecule real-time (SMRT) and Illumina RNA sequencing were used to uncover the gene expression differences in P. pygmaea under drought and rehydration conditions. The results showed that the total antioxidant capacity (TAOC) of P. pygmaea was significantly higher than P. massoniana and P. elliottii. TAOC showed a continuous increase trend across all species. Soluble sugar (SS), starch content and non-structural carbohydrate (NSC) of all three pines displayed a "W" pattern, declining initially, increasing, and then decreasing again. P. pygmaea exhibits stronger drought tolerance and greater recovery ability under prolonged drought conditions. Through the PacBio SMRT-seq, a total of 50,979 high-quality transcripts were generated, and 6,521 SSR and 5,561 long non-coding RNAs (LncRNAs) were identified. A total of 2310, 1849, 5271, 5947, 7710, and 6854 differentially expressed genes (DEGs) were identified compared to the control (Pp0D) in six pair-wise comparisons of treatment versus control. bHLH, NAC, ERF, MYB_related, C3H transcription factors (TFs) play an important role in drought tolerance of P. pygmaea. KEGG enrichment analysis and Gene set enrichment analysis (GSEA) analysis showed that P. pygmaea may respond to drought by enhancing metabolic processes such as ABA signaling pathway, alpha-linolenic acid. Weighted gene co-expression network analysis (WGCNA) revealed GST, CAT, LEC14B, SEC23 were associated with antioxidant enzyme activity and TAOC. This study provides a basis for further research on drought tolerance differences among coniferous species.
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- 2024
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44. Mechanical behaviors of backfill-rock composites: Physical shear test and back-analysis
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Jie Xin, Quan Jiang, Fengqiang Gong, Lang Liu, Chang Liu, Qiang Liu, Yao Yang, and Pengfei Chen
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Physical simulation ,Backfill-rock composites ,Shear failure ,Cracking ,Shear constitutive model ,Engineering geology. Rock mechanics. Soil mechanics. Underground construction ,TA703-712 - Abstract
The shear behavior of backfill-rock composites is crucial for mine safety and the management of surface subsidence. For exposing the shear failure mechanism of backfill-rock composites, we conducted shear tests on backfill-rock composites under three constant normal loads, compared with the unfilled rock. To investigate the macro- and meso-failure characteristics of the samples in the shear tests, the cracking behavior of samples was recorded by a high-speed camera and acoustic emission monitoring. In parallel with the experimental test, the numerical models of backfill-rock composites and unfilled rock were established using the discrete element method to analyze the continuous-discontinuous shearing process. Based on the damage mechanics and statistics, a novel shear constitutive model was proposed to describe mechanical behavior. The results show that backfill-rock composites had a special bimodal phenomenon of shearing load-deformation curve, i.e. the first shearing peak corresponded to rock break and the second shearing peak induced by the broken of aeolian sand-cement/fly ash paste backfill. Moreover, the shearing characteristic curves of the backfill-rock composites could be roughly divided into four stages, i.e. the shear failure of the specimens experienced: stage I: stress concentration; stage II: crack propagation; stage III: crack coalescence; stage IV: shearing friction. The numerical simulation shows that the existence of aeolian sand-cement/fly ash paste backfill inevitably altered the coalescence type and failure mode of the specimens and had a strengthening effect on the shear strength of backfill-rock composites. Based on damage mechanics and statistics, a shear constitutive model was proposed to describe the shear fracture characteristics of specimens, especially the bimodal phenomenon. Finally, the micro- and meso-mechanisms of shear failure were discussed by combining the micro-test and numerical results. The research can advance the better understanding of the shear behavior of backfill-rock composites and contribute to the safety of mining engineering.
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- 2024
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45. Assessment of the (Pro)renin Receptor Protein Expression in Organs
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Teng-Yao Yang, Pey-Jium Chang, Yu-Shien Ko, Siou-Ru Shen, and Shun-Fu Chang
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cardiovascular disease ,M8.9 fragment ,(pro)renin receptor ,renin-angiotensin system ,s(P)RR ,Biology (General) ,QH301-705.5 - Abstract
The (pro)renin receptor ((P)RR) is an essential component of the renin–angiotensin system (RAS) as a specific single-pass transmembrane receptor for prorenin and renin and has now emerged as a multifunctional protein implicated in a wide variety of developmental and physio-pathological processes and pathways. The (P)RR may be of pathological significance in metabolic syndrome. The (P)RR has received much consideration; substantial efforts have been made to understand the localization, regulation, and function of the (P)RR at both a molecular and system level. (P)RR regulation of cell function depends on whether it is intact or cleaved into its constituent forms. Therefore, the present chapter describes immunohistochemical approaches to examine the expression of (P)RR in various organs. It was shown that different molecular forms of (P)RR could be present in different tissue compartments in almost all organs. Among them, the liver has high PRR activity. Our findings could elucidate more detailed distribution of different (P)RR molecular forms in different organs, which could provide useful information to further investigate the pathophysiological mechanisms of the development of various diseases in the future.
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- 2024
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46. Research Progress on Food 3D Printing Based on Starch
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ZHU Yingying, WU Huajun, ZHU Jiawen, SHI Zhenxing, ZOU Liang, SHEN Ruiling, YAO Yang
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starch materials ,extrusion-based 3d printing ,physicochemical properties ,printing characteristics ,starch modification ,Food processing and manufacture ,TP368-456 - Abstract
Three-dimensional (3D) printing, also known as additive manufacturing, is an emerging manufacturing technology that enables personalized product design and precise modeling through digital control. In recent years, 3D printing technology has gained significant attention in the food industry due to its potential advantages, especially in the field of customized food processing. Starch is an important component of human diet, especially in the eastern diet structure primarily based on plant-based foods. Most starches possess excellent rheological, hydration, and gel properties, making them have natural advantages in outflow nozzle and printing molding and thus have great application potential in food 3D printing. In this article, recent progress in starch-based 3D printing is reviewed with respect to printing equipment types commonly used in starch-based 3D printing, printing technology using common starches as raw materials, the correlation between starch physicochemical properties and printing performance, starch modification for quality improvement of 3D printed products, the post-processing of starch-based 3D printed products and the influence of printing on starch structure. Furthermore, future prospects in the 3D printing field are presented.
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- 2024
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47. Macular hole following scleral buckling for rhegmatogenous retinal detachment: a case series
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Fangyu Wang, Zhongqiao Zhu, Hong Yan, Yao Yang, Laxiao Niu, and Jing Liu
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Macular hole ,Scleral buckling ,Rhegmatogenous retinal detachment ,Case series ,Clinical study ,Ophthalmology ,RE1-994 - Abstract
Abstract Background Macular hole (MH) development following scleral buckling (SB) surgery for rhegmatogenous retinal detachment (RRD) repair is rare. This study presents both full-thickness MH (FTMH) and lamellar MH (LMH) cases following SB for the treatment of RRD. Methods Clinical records of patients undergoing SB surgery for treatment of RRD at the Xi’an People’s Hospital (Xi’an Fourth Hospital) from January 2016 to December 2021 were reviewed, and cases with postoperative MH were selected. Clinical features and follow-up data were summarised, and possible causes were analysed. Results Among 483 identified cases (483 eyes), four eyes (three male patients, one female patient) had postoperative MH, with prevalence, mean age, and mean axial length of 0.83%, 43.5 ± 10.66 years, and 29.13 ± 3.80 mm, respectively. All patients did not undergo subretinal fluid (SRF) drainage. The mean time for detecting MH was 26 ± 15.5 days postoperatively. Macula-off RRD with high myopia and FTMH combined with retinal re-detachment were diagnosed in three patients. One patient had macula-on RRD with outer LMH. The average follow-up duration was 7.25 ± 1.5 months. The FTMH closed successfully after reoperation, while the outer LMH closed without intervention. Visual acuity insignificantly improved or slightly decreased in all patients. Conclusions Patients with high myopia combined with macula-off RRD might be more susceptible to FTMH, causing MH related retinal detachment. Additionally, LMH following SB was noted in patients with macula-on RRD. Therefore, we should raise awareness of MH following SB for RRD repair.
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- 2024
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48. Identification of cancer-keeping genes as therapeutic targets by finding network control hubs
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Zhang, Xizhe, Pan, Chunyu, Wei, Xinru, Yu, Meng, Liu, Shuangjie, An, Jun, Yang, Jieping, Wei, Baojun, Hao, Wenjun, Yao, Yang, Zhu, Yuyan, and Zhang, Weixiong
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Quantitative Biology - Molecular Networks ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Finding cancer driver genes has been a focal theme of cancer research and clinical studies. One of the recent approaches is based on network structural controllability that focuses on finding a control scheme and driver genes that can steer the cell from an arbitrary state to a designated state. While theoretically sound, this approach is impractical for many reasons, e.g., the control scheme is often not unique and half of the nodes may be driver genes for the cell. We developed a novel approach that transcends structural controllability. Instead of considering driver genes for one control scheme, we considered control hub genes that reside in the middle of a control path of every control scheme. Control hubs are the most vulnerable spots for controlling the cell and exogenous stimuli on them may render the cell uncontrollable. We adopted control hubs as cancer-keep genes (CKGs) and applied them to a gene regulatory network of bladder cancer (BLCA). All the genes on the cell cycle and p53 singling pathways in BLCA are CKGs, confirming the importance of these genes and the two pathways in cancer. A smaller set of 35 sensitive CKGs (sCKGs) for BLCA was identified by removing network links. Six sCKGs (RPS6KA3, FGFR3, N-cadherin (CDH2), EP300, caspase-1, and FN1) were subjected to small-interferencing-RNA knockdown in four cell lines to validate their effects on the proliferation or migration of cancer cells. Knocking down RPS6KA3 in a mouse model of BLCA significantly inhibited the growth of tumor xenografts in the mouse model. Combined, our results demonstrated the value of CKGs as therapeutic targets for cancer therapy and the potential of CKGs as an effective means for studying and characterizing cancer etiology., Comment: Contact the corresponding authors for supplementary material
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- 2022
49. Evaluation of a novel vaginal cells self‐sampling device for human papillomavirus testing in cervical cancer screening: A clinical trial assessing reliability and acceptability
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Chung‐Yao Yang, Ting‐Chang Chang, Hung‐Hsueh Chou, Angel Chao, Shih‐Tien Hsu, Yu‐Hsiang Shih, Huei‐Jean Huang, Cheng‐Tao Lin, Min‐Yu Chen, Lou Sun, Kuan‐Gen Huang, Kai‐Yun Wu, Wu‐Chiao Hsieh, Yi‐Ting Huang, Liang‐Hsuan Chen, Chien‐Hsing Lu, Hao Lin, and Chao‐Min Cheng
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acceptability ,cervical cancer screening ,HPV testing ,reliability ,self‐sampling ,Chemical engineering ,TP155-156 ,Biotechnology ,TP248.13-248.65 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Abstract Cervical cancer is a significant public health concern, particularly in low‐ and middle‐income countries where resources for prevention and treatment are limited. Routine screening, such as the Papanicolaou test (Pap smears) and human papillomavirus (HPV) testing, plays a crucial role in the early detection and prevention of cervical cancer. However, the participation rate in cervical cancer screening programs remains below optimal levels due to various factors. This study aimed to evaluate the reliability and acceptability of the HygeiaTouch Self Sampling Kit for Women in collecting vaginal samples for HPV typing, comparing the results with samples collected by physicians. The study included 1210 women aged 21–65 from three medical centers in Taiwan. The findings indicated that the self‐sampling kit was as effective as physician‐collected specimens in terms of obtaining valid samples and identifying HPV. The agreement between the two methods was 88%, with a κ value of 0.75. Furthermore, the study assessed the mechanical characteristics of the self‐sampling applicator through tensile, bending, and torque tests, and determined that it was safe for intravaginal use. Additionally, the study evaluated the safety and satisfaction of self‐sampling and found a low rate of adverse events (0.7%) and high levels of satisfaction (over 90%) among participants. Overall, we demonstrated that the HygeiaTouch Self Sampling Kit for Women is a reliable and acceptable device for HPV testing and cervical screening, providing a convenient, safe, and effective alternative for women.
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- 2024
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50. Design and Analysis of High Data Rate Four-Dimensional Index Modulation for Differential Chaos Shift Keying System.
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Gang Zhang, Xinggen Wu, Yao Yang, and Shun Shao
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- 2024
- Full Text
- View/download PDF
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