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Graphdiyne (GDY) is a new 2D carbon material different from graphene, and its ideal drug carrying and photothermal therapy efficacy had been noticed recently. Graphdiyne-oxide (GDYO), which few phototherapy researches had been reported, has more oxygen functional groups than GDY. Metal-organic framework materials Fe3O4@UiO-66-NH2 (FU) can covalently connect to GDYO layers and obtain covalent-organic framework-like structures FUGYO. FU enlarged interlamellar space of GDYO, which avoided the aggregation of FUGYO multiple layers. At the same time, more acetylenic bonds and hydrophilic group were exposed, which brings out advantages like stability, hydrophily, high drug-loading, as well as magnetic targeting and better magnetic resonance imaging efficacy. To promote cancer treatment effect and water solubility, we loaded chemotherapy drug doxorubicin (DOX) in FUGYO, then encapsulated FUGYO/DOX in phosphatidylcholine and fluorescent organic polymer BODIPY-PEG (BP) to integrate image-guided and synergistic therapy in one nanoparticle (BPFG/DOX). Due to the unique structure of BPFG/DOX, the π–π interaction between GDYO and BP improved photodynamic therapy efficiency. About 10 μg ml−1 BPFG/DOX have nearly 90% cell lethality to MCF-7 (human breast cancer cell line) cells with laser irradiation. In vivo, BPFG/DOX possessed ideal magnetic targeting and effectively inhibited tumor growth in 6 d. In conclusion, BPFG/DOX not only acts as an excellent tumor theranostic agent but also provides a scheme for applying GDYO in the biomedical region.

Photodynamic therapy (PDT) has a successful track record in cancer. . Urea is a naturally occurring metabolite in the human body. Some studies have shown that it can inhibit the proliferation of tumor cells and cause oxidative stress. In order to explore the application of urea in enhancing the PDT effect, we synthesized a new photosensitizer (BODIPY-I-35) with good phototherapeutic effect and encapsulated it in liposomes. Compared with free BODIPY-I-35, water-soluble nanoliposomes (LipoBOD) produced a huge redshift ( 122 nm) of fluorescence emission in solution. When LipoBOD was irradiated with 808 nm laser (1 W/cm

The combination of chemotherapy and photodynamic therapy has been proved to be a promising therapy for drug-resistant cancers. In this study, we report, for the first time, a novel two-fold interpenetration pillar-layered metal-organic frameworks (MOFs) material, using BODIPY-derivate bipyridine as linker and Photosensitizer (PS), named BBP-MOFs, was successfully synthesized to serve as a drug carrier and Photodynamic agent simultaneously. The BBP-MOFs could generate singlet oxygen (1O2) to perform PDT under 660 nm light irradiation, in the meantime, the anticancer drugs doxorubicin (DOX) could be loaded for chemotherapy. The results showed that BBP-MOFs exhibited a high drug loading content of 49.7% a controlled drug release and ideal biocompatibility. This DOX loaded BBP-MOFs was readily taken up by HeLa cells, and high levels of 1O2 were generated under light irradiation. This work provided strong evidence for BBP-MOFs as a promising new anticancer drug carrier and PDT candidate, the PDT and chemotherapy combined synergistic therapy revealed high therapeutic efficacy for cancer cells.

We investigate the adsorption behavior of methyl orange (MO) on composite xerogels. Mesoporous TiO2-SiO2 and TiO2-SiO2-Al2O3 xerogels are prepared by hydrolysis of tetraethyl orthosilicate (TEOS), tetrabutyl orthotitanate (TBOT), and AlCl3 ·6H2O using HCl as a catalyst and cetyltrimethylammonium bromide (CTAB) as a templating agent. The corresponding microporous xerogels are also prepared without addition of CTAB. These xerogels are then characterized by XRD, FTIR, and BET.We find that MO is adsorbed by the mesoporous xerogels in acidic solutions, showing Langmuir type adsorption isotherms. We also find that the adsorption decreases with increasing temperature. It is suggested that adsorption exhibits a sieve effect and that MO is adsorbed through electrostatic attraction and hydrogen bonding between MO and the xerogels.

Methyl orange (MO) and phenolphthalein (P) doped SiO2 gels derived from tetraethyl orthosilicate (TEOS) and modified with cetyltrimethylammonium bromide (CTAB), sodium dodecyl sulfate (SDS) and stearic acid (SA) are prepared. FTIR and TG analyses are used to characterize the gels. The color changes and leaching behavior of MO and P within the gels are investigated and explained on the basis of the gel structures and the reaction mechanism. The experimental results show that surface-active substances have obvious effects on the acid–base response and the leaching behavior of the acid–base indicators within the SiO2 gels.