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2. Growth Hormone to Improve Short Bowel Syndrome Intestinal Autonomy : A Pediatric Randomized Open-Label Clinical Trial

Author

Peretti, N., Loras-Duclaux, I., Kassai, Behrouz, Restier-Miron, L., Guimber, D., Gottrand, F., Coopman, S., Michaud, L., Marinier, E., Yantren, H., Michalski, Marie-Caroline, Aubert, F., Pelosse, M., Lopez, Morgan, Chatelain, P., Lachaux, A., Mercier, Catherine, Evaluation et modélisation des effets thérapeutiques, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), and Hospices Civils de Lyon (HCL)

Subjects
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]
Published
2011

4. Growth hormone to improve short bowel syndrome intestinal autonomy: a pediatric randomized open-label clinical trial.

Author

Peretti N, Loras-Duclaux I, Kassai B, Restier-Miron L, Guimber D, Gottrand F, Coopman S, Michaud L, Marinier E, Yantren H, Michalski MC, Aubert F, Mercier C, Pelosse M, Lopez M, Chatelain P, and Lachaux A

Subjects
Child, Human Growth Hormone therapeutic use, Humans, Intestine, Small pathology, Male, Prospective Studies, Short Bowel Syndrome pathology, Weight Loss, Energy Intake drug effects, Human Growth Hormone pharmacology, Intestine, Small drug effects, Parenteral Nutrition, Short Bowel Syndrome therapy
Abstract

Background: The ability of growth hormone (GH) to promote the weaning-off of parenteral nutrition (PN) in short bowel syndrome (SBS) is unclear. No randomized controlled study is available in children. This study was undertaken to determine if GH could enhance the weaning off of PN in PN-dependent children with SBS., Methods: A prospective randomized open-label multicenter study was performed in 14 patients (mean age, 9 ± 1.4 years) with SBS (average small bowel length, 33 cm) and long-term PN dependency (8 years) on an unrestricted diet. A standardized PN decrease with and without GH (0.14 mg/kg/d) was conducted. The patients were randomized to either a GH group (4 months of GH) or a control (CTR) group (4 months without GH, followed by 4 months with GH). Blood tests and a nutrition assessment of enteral and parenteral intakes were performed. Groups were compared with the Wilcoxon test., Results: Treatment with GH did not improve the weaning off of PN (decrease in PN caloric intake of 32.5% ± 9.6% in the GH group vs 35.2% ± 8.7% in the CTR group, nonsignificant). In the CTR group, GH treatment induced an additional but not statistically significant decrease of 8.8% ± 12.4% in daily calories. Parenteral needs returned to near basal rates 6 months after GH discontinuation (GH: 77.6% ± 10.6% vs CTR: 73.2% ± 7.4%). Weight decreased slightly in both groups. No biological parameters varied significantly., Conclusions: GH did not improve the weaning off of PN in PN-dependent children with SBS.

Published
2011
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5. [Granulomatous pulmonary involvement preceding diagnosis of Crohn disease: a pediatric case report].

Author

Roblin E, Pecciarini N, Yantren H, Dubois R, Hameury F, Bellon G, Bouvier R, and Lachaux A

Subjects
Adolescent, Crohn Disease drug therapy, Diagnosis, Differential, Female, Granulomatous Disease, Chronic diagnosis, Granulomatous Disease, Chronic drug therapy, Humans, Lung Diseases diagnosis, Lung Diseases drug therapy, Respiratory Function Tests, Severity of Illness Index, Time Factors, Treatment Outcome, Crohn Disease complications, Crohn Disease diagnosis, Granulomatous Disease, Chronic etiology, Lung Diseases etiology
Abstract

Crohn disease (CD) is a chronic bowel disorder that may affect many other organs such as the eyes, hepatobiliary system, skin, and joints. Pulmonary involvement in association with CD is a classic but uncommon manifestation. It can be primitive with granulomas or secondary to treatments. We report on the case of a teenager in whom the onset of CD was dominated by respiratory symptoms. Because of this presentation, we also suspected opportunistic infections such as tuberculosis and other granulomatous pulmonary diseases such as sarcoidosis or hypersensitivity pneumonitis., (Copyright © 2010. Published by Elsevier SAS.)

Published
2010
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6. Intellectual and visuo-spatial assessment in long-term pediatric liver transplantation for biliary atresia.

Author

Yssaad-Fesselier R, Lion-François L, Herbillon V, Rivet C, Brunet AS, Yantren H, Bost M, and Lachaux A

Subjects
Biliary Atresia psychology, Child, Female, Humans, Male, Memory, Speech Perception, Thinking, Wechsler Scales, Biliary Atresia surgery, Intelligence Tests, Liver Transplantation physiology, Liver Transplantation psychology, Space Perception, Visual Perception
Published
2009
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