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18 results on '"Yant, Levi J."'

1. Reversion of CTL escape–variant immunodeficiency viruses in vivo

Author

Friedrich, Thomas C, Dodds, Elizabeth J, Yant, Levi J, Vojnov, Lara, Rudersdorf, Richard, Cullen, Candice, Evans, David T, Desrosiers, Ronald C, Mothé, Bianca R, Sidney, John, Sette, Alessandro, Kunstman, Kevin, Wolinsky, Steven, Piatak, Michael, Lifson, Jeffrey, Hughes, Austin L, Wilson, Nancy, O'Connor, David H, and Watkins, David I

Published
2004
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3. Repression of Flowering by the miR172 Target SMZ

Author

Mathieu, Johannes, Yant, Levi J., Muerdter, Felix, Kuettner, Frank, Schmid, Markus, Mathieu, Johannes, Yant, Levi J., Muerdter, Felix, Kuettner, Frank, and Schmid, Markus

Abstract

Times Cited: 142

Published
2009

5. Comprehensive Immunological Evaluation Reveals Surprisingly Few Differences between Elite Controller and Progressor Mamu-B*17 -Positive Simian Immunodeficiency Virus-Infected Rhesus Macaques

Author

Maness, Nicholas J., primary, Yant, Levi J., additional, Chung, Chungwon, additional, Loffredo, John T., additional, Friedrich, Thomas C., additional, Piaskowski, Shari M., additional, Furlott, Jessica, additional, May, Gemma E., additional, Soma, Taeko, additional, León, Enrique J., additional, Wilson, Nancy A., additional, Piontkivska, Helen, additional, Hughes, Austin L., additional, Sidney, John, additional, Sette, Alessandro, additional, and Watkins, David I., additional

Published
2008
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6. Subdominant CD8+T-Cell Responses Are Involved in Durable Control of AIDS Virus Replication

Author

Friedrich, Thomas C., primary, Valentine, Laura E., additional, Yant, Levi J., additional, Rakasz, Eva G., additional, Piaskowski, Shari M., additional, Furlott, Jessica R., additional, Weisgrau, Kimberly L., additional, Burwitz, Benjamin, additional, May, Gemma E., additional, León, Enrique J., additional, Soma, Taeko, additional, Napoe, Gnankang, additional, Capuano, Saverio V., additional, Wilson, Nancy A., additional, and Watkins, David I., additional

Published
2007
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8. The High-Frequency Major Histocompatibility Complex (MHC) Class I Allele Mamu-B*17 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication

Author

Yant, Levi J., primary, Friedrich, Thomas C., additional, Johnson, Randall C., additional, May, Gemma E., additional, Maness, Nicholas J., additional, Enz, Alissa M., additional, Lifson, Jeffrey D., additional, O'Connor, David H., additional, Carrington, Mary, additional, and Watkins, David I., additional

Published
2006
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9. Vaccine-Induced Cellular Immune Responses Reduce Plasma Viral Concentrations after Repeated Low-Dose Challenge with Pathogenic Simian Immunodeficiency Virus SIVmac239

Author

Wilson, Nancy A., primary, Reed, Jason, additional, Napoe, Gnankang S., additional, Piaskowski, Shari, additional, Szymanski, Andy, additional, Furlott, Jessica, additional, Gonzalez, Edna J., additional, Yant, Levi J., additional, Maness, Nicholas J., additional, May, Gemma E., additional, Soma, Taeko, additional, Reynolds, Matthew R., additional, Rakasz, Eva, additional, Rudersdorf, Richard, additional, McDermott, Adrian B., additional, O'Connor, David H., additional, Friedrich, Thomas C., additional, Allison, David B., additional, Patki, Amit, additional, Picker, Louis J., additional, Burton, Dennis R., additional, Lin, Jing, additional, Huang, Lingyi, additional, Patel, Deepa, additional, Heindecker, Gwendolyn, additional, Fan, Jiang, additional, Citron, Michael, additional, Horton, Melanie, additional, Wang, Fubao, additional, Liang, Xiaoping, additional, Shiver, John W., additional, Casimiro, Danilo R., additional, and Watkins, David I., additional

Published
2006
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10. The High-Frequency Major Histocompatibility Complex Class I Allele Mamu-B*17 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication

Author

Yant, Levi J., primary, Friedrich, Thomas C., additional, Johnson, Randall C., additional, May, Gemma E., additional, Maness, Nicholas J., additional, Enz, Alissa M., additional, Lifson, Jeffrey D., additional, O'Connor, David H., additional, Carrington, Mary, additional, and Watkins, David I., additional

Published
2006
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11. Tat 28-35 SL8-Specific CD8 + T Lymphocytes Are More Effective than Gag 181-189 CM9-Specific CD8 + T Lymphocytes at Suppressing Simian Immunodeficiency Virus Replication in a Functional In Vitro Assay

Author

Loffredo, John T., primary, Rakasz, Eva G., additional, Giraldo, Juan Pablo, additional, Spencer, Sean P., additional, Grafton, Kelly K., additional, Martin, Sarah R., additional, Napoé, Gnankang, additional, Yant, Levi J., additional, Wilson, Nancy A., additional, and Watkins, David I., additional

Published
2005
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12. Consequences of Cytotoxic T-Lymphocyte Escape: Common Escape Mutations in Simian Immunodeficiency Virus Are Poorly Recognized in Naïve Hosts

Author

Friedrich, Thomas C., primary, McDermott, Adrian B., additional, Reynolds, Matthew R., additional, Piaskowski, Shari, additional, Fuenger, Sarah, additional, de Souza, Ivna P., additional, Rudersdorf, Richard, additional, Cullen, Candice, additional, Yant, Levi J., additional, Vojnov, Lara, additional, Stephany, Jason, additional, Martin, Sarah, additional, O'Connor, David H., additional, Wilson, Nancy, additional, and Watkins, David I., additional

Published
2004
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13. Repeated Low-Dose Mucosal Simian Immunodeficiency Virus SIVmac239 Challenge Results in the Same Viral and Immunological Kinetics as High-Dose Challenge: a Model for the Evaluation of Vaccine Efficacy in Nonhuman Primates

Author

McDermott, Adrian B., primary, Mitchen, Jacque, additional, Piaskowski, Shari, additional, De Souza, Ivna, additional, Yant, Levi J., additional, Stephany, Jason, additional, Furlott, Jessica, additional, and Watkins, David I., additional

Published
2004
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14. Extraepitopic Compensatory Substitutions Partially Restore Fitness to Simian Immunodeficiency Virus Variants That Escape from an Immunodominant Cytotoxic-T-Lymphocyte Response

Author

Friedrich, Thomas C., primary, Frye, Christopher A., additional, Yant, Levi J., additional, O'Connor, David H., additional, Kriewaldt, Nancy A., additional, Benson, Meghan, additional, Vojnov, Lara, additional, Dodds, Elizabeth J., additional, Cullen, Candice, additional, Rudersdorf, Richard, additional, Hughes, Austin L., additional, Wilson, Nancy, additional, and Watkins, David I., additional

Published
2004
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15. Control of Simian Immunodeficiency Virus SIVmac239 Is Not Predicted by Inheritance of Mamu-B*17-Containing Haplotypes.

Author

Wojcechowskyj, Jason A., Yant, Levi J., Wiseman, Roger W., O'Connor, Shelby L., and O'Connor, David H.

Subjects
*MAJOR histocompatibility complex, *HIV, *RHESUS monkeys, *SIMIAN viruses, *MACAQUES, *DISEASES
Abstract

It is well established that host genetics, especially major histocompatibility complex (MHC) genes, are important determinants of human immunodeficiency virus disease progression. Studies with simian immunodeficiency virus (SIV)-infected Indian rhesus macaques have associated Mamu-B*17 with control of virus replication. Using microsatellite haplotyping of the 5-Mb MHC region, we compared disease progression among SIVmac239-infected Indian rhesus macaques that possess Mamu-B*17-containing MHC haplotypes that are identical by descent. We discovered that SIV-infected animals possessing identical Mamu-B*17-containing haplotypes had widely divergent disease courses. Our results demonstrate that the inheritance of a particular Mamu-B*17-containing haplotype is not sufficient to predict SIV disease outcome. [ABSTRACT FROM AUTHOR]

Published
2007
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16. The High-Frequency Major Histocompatibility Complex Class I Allele Mamu-B*17 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication.

Author

Yant, Levi J., Friedrich, Thomas C., Johnson, Randall C., May, Gemma E., Maness, Nicholas J., Enz, Alissa M., Lifson, Jeffrey D., O'Connor, David H., Carrington, Mary, and Watkins, David I.

Subjects
*HIV, *IMMUNODEFICIENCY, *RHESUS monkeys, *VIRUSES, *HIV infections
Abstract

Particular HLA alleles are associated with reduced human immunodeficiency virus replication. It has been difficult, however, to characterize the immune correlates of viral control. An analysis of the influence of major histocompatibility complex class I alleles on viral control in 181 simian immunodeficiency virus SIVmac239-infected rhesus macaques revealed that Mamu-B*17 was associated with a 26-fold reduction in plasma virus concentrations (P < 0.001). Mamu-B*17 was also enriched 1,000-fold in a group of animals that controlled viral replication. Even after accounting for this group, Mamu-B*17 was associated with an eightfold reduction in plasma virus concentrations (P < 0.001). Mamu-B*17-positive macaques could, therefore, facilitate our understanding of the correlates of viral control. [ABSTRACT FROM AUTHOR]

Published
2006
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17. Subdominant CD8+ T-Cell Responses Are Involved in Durable Control of AIDS Virus Replication.

Author

Friedrich, Thomas C., Valentine, Laura E., Yant, Levi J., Rakasz, Eva G., Piaskowski, Shari M., Furlott, Jessica R., Weisgrau, Kimberly L., Burwitz, Benjamin, May, Gemma E., León, Enrique J., Soma, Taeko, Napoe, Gnankang, Capuano III, Saverio V., Wilson, Nancy A., and Watkins, David L.

Subjects
*HIV, *HTLV, *VIRAL replication, *REPRODUCTION, *SIMIAN viruses
Abstract

"Elite controllers" are individuals that durably control human immunodeficiency virus or simian immunodeficiency virus replication without therapeutic intervention. The study of these rare individuals may facilitate the definition of a successful immune response to immunodeficiency viruses. Here we describe six Indian-origin rhesus macaques that have controlled replication of the pathogenic virus SIVmac239 for 1 to 5 years. To determine which lymphocyte populations were responsible for this control, we transiently depleted the animals' CD8+ cells in vivo. This treatment resulted in 100- to 10,000-fold increases in viremia. When the CD8+ cells returned, control was reestablished and the levels of small subsets of previously subdominant CD8+ T cells expanded up to 2,500-fold above predepletion levels. This wave of CD8+ T cells was accompanied by robust Gag-specific CD4 responses. In contrast, CD8+ NK cell frequencies changed no more than threefold. Together, our data suggest that CD8+ T cells targeting a small number of epitopes, along with broad CD4+ T-cell responses, can successfully control the replication of the AIDS virus. It is likely that subdominant CD8+ T-cell populations play a key role in maintaining this control. [ABSTRACT FROM AUTHOR]

Published
2007
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18. Tat28-35SL8-Specific CD8+ T Lymphocytes Are More Effective than Gag181-189CM9-Specific CD8+ T Lymphocytes at Suppressing Simian Immunodeficiency Virus Replication in a Functional In Vitro Assay.

Author

Loffredo, John T., Rakasz, Eva G., Giraldo, Juan Pablo, Spencer, Sean P., Grafton, Kelly K., Martin, Sarah R., Gnankang Napoé, Yant, Levi J., Wilson, Nancy A., and Watkins, David I.

Subjects
*VIRAL replication, *T cells, *HIV, *SIMIAN viruses, *HIV infections, *ANTIVIRAL agents, *EPITOPES
Abstract

Epitope-specific CD8+ T lymphocytes may play an important role in controlling human immunodeficiency virus (HIV)/simian immunodeficiency virus replication. Unfortunately, standard cellular assays do not measure the antiviral efficacy (the ability to suppress virus replication) of CD8+ T lymphocytes. Certain epitope-specific CD8+ T lymphocytes may be better than others at suppressing viral replication. We compared the antiviral efficacy of two immunodominant CD8+ T lymphocyte responses—Tat28–35SL8 and Gag181–189CM9—by using a functional in vitro assay. Viral suppression by Tat-specific CD8+ T lymphocytes was consistently greater than that of Gag-specific CD8+ T lymphocytes. Such differences in antigen-specific CD8+-T-lymphocyte efficacy may be important for selecting CD8+ T lymphocyte epitopes for inclusion in future HIV vaccines. [ABSTRACT FROM AUTHOR]

Published
2005
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