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Social justice is a path to the reduction of inequality and one of the key milestones of sustainable development in the materials by the UN. However, there is a methodological gap, which hinders measuring the level of an economic system's social justice. The discovered gap is filled in here through the development of the analytical methodology of measuring social justice with the help of such criterion as the quality of income. Quality of income is measured from the positions of the influence of the quality of income on the quality of the population's life (according to the materials of "Quality of Life Index of the Numbeo (2021)) and the level of happiness in society (according to the materials of World Happiness Report (2021)). For the treatment of the results of the evaluation, we develop an analytical matrix. According to it, high (nominal, quantitative) income must ensure an increase in the quality of life and an increase in the level of happiness in society. In this case, the quality of income could be deemed high, and society - just. The developed proprietary methodological approach is approbated by the example of various developed and developing countries, which allows characterizing the level and differences in the quality of income and social justice of countries of the selected categories and proposing recommendations for the increase in the quality of income.

The article is dedicated to the review of the theoretical and experimental research of the Russian and foreign scientists in the enzymes both in native state and in forms of chemically stabilized nanosized particles, promising for the development of military products of different types. It summarises the results of use of biocatalysts on the basis of enzymes and microorganisms­destructors for the neutralization of eco­toxicants. The nature of enzymes is analyzed. The significant part of the article is dedicated to the data obtained regarding the sphere of biochemical and medical biocatalytic technologies for the development of enzymatic prophylactic and therapeutic means. A special attention is paid to the enzymes, used in protective equipment, to environmental biocatalysts, to biopharmaceuticals on the basis of enzymes and microorganisms­destructors for the utilization of reaction masses, to chemical detoxification of poisonous substances. The authors point out the main trends in the further research in the sphere of biotechnologies: enzymatic pharmaceuticals for prophylaxis and treatment of OP poisoning; enzymes in self­degassing materials and in protective equipment; biocatalysts for soil, water and surface purification; biopharmaceuticals on the basis of enzymes and microorganisms­destructors for the degradation of reaction masses of toxic chemicals.

The work presents an overview of the main results of experimental and theoretical researches made by the Federal State Budgetary Establishment «27 Scientific Centre» of the Ministry of Defence of the Russian Federation together with other scientific organizations and institutions in 1989–2014 in the sphere of the development of biocatalysts, and biotechnological methods of destruction of chemical warfare agents (organophosphorus agents) and the products of their detoxication, including the reactionary masses, obtained during the industrial destruction of chemical weapons. The article shows that the methods of the remediation of soil and purification of water with the usage of microorganisms-destructors or their consortiums and their enzymes can be used for the neutralization of any detoxication products of chemical warfare agents, obtained by the usage of different technologies of chemical neutralization. This indicates the possibility of environmentally friendly neutralization and detoxification of considerable volume and concentrations of agents as well as large territories at the sites of former production, storage and destruction of chemical warfare agents. These eco-friendly and safe neutralization and detoxification technologies can be based on microbial biocatalytic processes. The authors assert that on the basis of the analysis mentioned above it is possible to substantiate the choice of the enzymes and the strains with high destruction ability and tolerance towards toxic agents, to elaborate the technological schemes of the production of the eco-biopreparations (biocatalysts) on the basis of the enzymes and microorganizms-destructors and to develop the technological schemes of the remediation of soil and purification of water using biocatalyst-enzymes and immobilized bacterial cells.

This article analyses some aspects of the socioeconomic and political uses of anniversaries in the Soviet and contemporary Russian history to boost the development of the territory. Initially, the desire of the young Soviet state to sever all ties with the past made the “anniversary question” almost absurd. Soviet anniversary traditions formed in the late 1920s–1930s when the 3rd, 5th, 10th, 15th, and 20th anniversaries of organisations and enterprises were celebrated everywhere. The article also mentions personal anniversaries, which celebrated the time of work in a particular institution, or in a particular specialty and other reasons. Additionally, the author considers the political decisions of the Soviet / Russian authorities on the regulation of the “anniversary question”. Starting with the late 1940s, the anniversary of a city could be a political campaign, a way of symbolic mobilisation and accumulation of resources. On the other hand, cities’ anniversaries caused a surge in local historical and cultural activism, contributed to the formation of local lore communities, and stimulated the formation of local identity. Particular attention is paid to the resonant “dispute of historians” considering the date of foundation of the city of Perm at the turn of the 1970s, which is personified in the controversy between F. S. Gorovoy and B. N. Nazarovsky becoming a model for the establishment of anniversaries of local centres. A new interpretation of the above polemic is proposed in the context of the Soviet public history formation. The first full-scale anniversary of Perm (as well as a few other Soviet cities) demonstrated its potential as a socioeconomic technology and stimulated urban development and accumulation of the provincial / regional capital. The celebration of anniversaries forms a specific temporality of key dates and gives an impetus to the development of the symbolic component of metropolitan identity.

The social responsibility of religious organizations in modern conditions is reflected in a variety of activities carried out by religious institutions and differ depending on both the confessional affiliation of these institutions and the specific structural territorial unit where they take place. The presented work is devoted to a detailed analysis of the peculiarities of the manifestation of one of the directions of social responsibility of the Evangelical Lutheran Church of Denmark (ELCD), associated with minimizing the consequences of COVID-19 on the example of its individual dioceses. The dioceses characterized by the highest proportion of adherents in the population structure (Diocese of Viborg, Ribe, Aalborg and Lolland-Faster) were selected to clearly reflect the trends taking place. The subject of the study is the social activities of the ELCD to mitigate the consequences of COVID-19 for parishioners, the features of the implementation of which are considered on the example of structural units at the regional level. The article substantiates the increased importance of the ELCD in the development of the region, since the designated institution largely assumes the social obligations of the state (duplicates several functions) in connection with the risks of the spread of coronavirus infection. To achieve the goal, methods of analysis of factual and economic-statistical information, comparative comparison were used. The experience of a religious organization in dealing with the consequences of the COVID-19 pandemic is of interest to the public, government bodies and authorities, as well as religious organizations in other countries. The results of the study can be useful in developing a strategy for the development of state-religious relations in Russia, where there are trends of strengthening the social and economic role of religious organizations.

Aim of the work: to demonstrate the difficulty of verifying the diagnosis of Q fever with negative results of PCR (DNA of Coxiella burnetii) in the blood and to assess the occurrence of serological markers among patients selected for this study based on a combination of clinical and epidemiological data. Materials and methods: plasma/serum samples of 111 patients according to clinical and epidemiological data studied due ELISA and PCR for specific antibodies to Coxiella burnetii and DNA of pathogen. Additionally, in the presence IgG to C. burnetii phase II, IgG / IgA to phase I and the avidity of specific IgG were studied. Results: the specific antibodies to C. burnetii antigens at negative results of PCR detected in 10 cases. The article provides the description of three clinical cases for demonstration of difficulties of coxiellosis diagnosis with analysis of serological profiles, titers and avidity of antibodies. Conclusion: the results of the study indicate that negative results of PCR testing do not exclude C. burnetii infection. For patients who, according to clinical and epidemiological data, Q fever is not excluded, it is advisable to prescribe a complex of laboratory tests to verify the diagnosis, which includes not only studies of the pathogen’s DNA, but also specific antibodies. To clarify the stage of the disease and reduce the risk of developing complications of coxiellosis, it is necessary to monitor the dynamics of antibody titers to C. burnetii in phase I and II phase states differentially.

This article delves into social entrepreneurship experience and fills a void in the extant literature by determining the post-COVID perspective contribution of social entrepreneurship activities. The research presents a nuanced perspective on the potential impact of social entrepreneurship on sustainable development across various geographical areas. We highlight an essential discovery that social entrepreneurship impacts sustainable development across diverse geographical regions. When addressing the COVID-19 pandemic, we must consider economic reasoning, theoretical implications, and geographical and socio-economic factors. Such considerations would significantly contribute to our collective efforts to overcome this global crisis. Adopting a strategic and effective method towards social entrepreneurship can accelerate the achievement of SDGs and promote equitable, sustainable development.

BACKGROUND: Obesity and androgen deficiency (AnD) are characterized by similar disturbances in metabolic parameters, the presence of signs of insulin resistance, metabolic syndrome, the risk of developing cardiovascular diseases (CVD) and vascular complications. These facts indicate the possibility of the presence of common mechanisms that determine the predisposition to the development of obesity and AnD, which may include genetic factors, in particular, the rs4646994 polymorphism of the ACE gene, which, according to recent data, is associated with the risk of developing CVD, hypertension, and obesity.AIM: To study the association of the carriage of polymorphic variants of the rs4646994 locus of the ACE gene with the features of anthropometric and androgenic status in men.MATERIALS AND METHODS: In the period from April 2020 to October 2021 there were observed male patients aged 18–75 years old, who were hospitalized in a therapeutic hospital because of comorbid somatic pathology (hypertension, coronary heart disease, dorsopathy, vegetative-vascular dystonia, gastroesophageal reflux disease, and others). Anthropometry, a study of the content of hormones of the reproductive system in the blood serum using enzyme-linked immunosorbent assay (ELISA), as well as a genetic study for the carriage of polymorphic variants of the rs4646994 locus of the ACE gene by the polymerase chain reaction (PCR) method, followed by electrophoresis of PCR products, were carried out. RESULTS: 82 patients took part in research. According to the results of genetic analysis, 17 people were assigned to the group of homozygotes for the wild type (I/I, G1), 41 people were assigned to the group of heterozygotes (I/D, G2), and 41 people were assigned to the group of homozygotes for the mutant allele (D/D, G3) 24 people. Body weight, chest circumference, waist and hips, body mass index in patients carrying the D allele of the rs4646994 polymorphism were statistically significantly higher than in I/I homozygotes. Differences in hormonal status also turned out to be statistically significant: patients from G1 compared with G2 and G3 had higher levels of total testosterone; from G1 compared to G3 — a higher level of free testosterone.CONCLUSION: An association of the carriage of the D allele of the rs4646994 polymorphic locus of the ACE gene with overweight and ADI was revealed.

Antibiotics are widely used in animal husbandry for livestock treatment, as well as in feed additives, as growth promoters. Antibiotics are sometimes used to preserve food and extend shelf life in the food industry. One can often encounter the falsification of agricultural raw materials and finished products with antibiotics for the same purposes. Antibiotics can get into food through animals. Milk and dairy products occupy an important place among food products; they are especially necessary for the younger generation. Currently, antibiotics are considered a serious factor in the contamination of food products, as well as a source of antibiotic resistance and food allergies. The international community is concerned about the problem associated with the steady development of pathogenic microorganisms’ resistance to the drugs currently in use. According to expert estimates, about 700 thousand people die every year globally due to the resistance of pathogenic microorganisms. As a result, the problem of negative impact of antibiotics on humans becomes crucial. Different countries, the WHO, the WTO, and the EAEU, which includes the Russian Federation, adopt regulations and special laws that limit the use of antibiotics in the agro-industrial complex. Therefore, the problem of studying the risks of contamination of food and dairy products with antibiotics is a pressing matter.

Background. According to the literature data, long-term and poorly controlled hypertension (HTN) leads to target organs damage, and in some cases, to the development of associated diseases, the severity of which in men may be partly due to the characteristics of the androgenic status.The aim: to reveal the features of hormonal indicators of androgen status and their relationship with the anthropometric and metabolic characteristics of the therapeutic clinic male patients, depending on the severity of HTN.Materials and methods. 296 men aged 59,0 [54,0; 65,0] years with confirmed HTN were examined. All study participants in the morning on an empty stomach underwent anthropometry, determination of metabolic and androgenic status, and assessment of comorbid burden. Depending on the severity of hypertension, all patients were divided into two groups (G): G1 (n = 134) – patients with hypertension without a history of coronary artery disease or stroke; G2 (n = 162) – patients with hypertension with a history of ischemic heart disease (IHD) and/or stroke.Results. In male patients of G2 with severe HTN, a decrease in the levels of free testosterone (FT) and, to a greater extent, dehydroepiandrosterone sulfate (DHEA-S), as well as total cholesterol, high and low density lipoproteins, was revealed. The correlation analysis performed revealed statistically significant negative correlations between the levels of total testosterone (TT) and FT with body mass index, the value of the ratio of waist circumference to hips, only the level of FT – with the presence of IHD, chronic heart failure (CHF), disorders of carbohydrate metabolism and abdominal type of fat distribution, and the level of DHEA-S – with the presence of IHD and CHF.Conclusion. A decrease in FT and DHEA-S is associated with early progression of atherosclerosis and the risk of developing HTN-associated cardiovascular events, which can aggravate the course of HTN.

Link for citation: Yankovsky S.A., Lavrinenko S.V., Tsibulskiy S.A., Yankovskaya N.S., Gamov D.L. Cycle diagram of geothermal energy. Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2023, vol. 334, no. 7, рр. 122-136. In Rus. The relevance of the research is caused by the need to develop alternative and environmentally friendly energy sources in conditions of global warming. The development of geothermal energy will make it possible to produce thermal and electric energy without emissions of CO2 into the environment and reduce the dependence of the energy sector on hydrocarbon raw materials. The main aim of this study is a comprehensive analysis of the features of geothermal power plants, including the existing technologies for converting geothermal energy to provide consumers of electric and thermal energy. Objects: diagrams of geothermal power plants operating in different geographical and climatic conditions, as well as their working fluids. Methods: analytical review of thematic publications using the materials of the databases of the RSCI, Scopus and Web of Science, a comparative analysis of the effectiveness of geothermal power plants for various indicators. Results. Currently, there are about 400 geothermal power plants in the world. The active development of geothermal energy is caused by environmental friendliness, low cost of energy produced, minimal operating costs, lack of dependence on atmospheric influences, and the absence of the need to burn fuel, etc. At the same time, most of the world's geothermal power plants use the energy of a geothermal source with a water temperature of 100–200 °C. Among the main thermodynamic cycles and thermal schemes implemented, it is possible to single out direct cycle geothermal power plants with one-stage and two-stage separation of a geothermal source, with direct supply of dry steam to the turbine, binary and combined versions. The analysis shows that direct cycle geothermal power plants have the lowest cost of installed electrical power due to the relative simplicity and high thermal efficiency, but require high parameters of a geothermal source. On the other hand, binary geothermal power plants have the highest unit cost, but can be implemented on geothermal sources with relatively low water parameters, which was the main reason for their greatest spread in the world. At the same time, the implementation of a binary geothermal power plant with a Organic Rankine сycle has a number of advantages compared to the thermodynamic cycles of Kalina, Stirling and Brighton, among which the main ones are relative ease of adaptation and application, as well as low maintenance costs.

Considering the growing interest of the Russian society in fermented dairy products, in particular, cream cheese enriched with probiotic cultures and biologically active substances (BAS), it is relevant to conduct research aimed at scientifically justifying the choice of biotechnology of curd production as a raw material for cream cheese by studying the influence of biotechnological and technological factors on the formation of properties of the used curd. The generally accepted methods of qualitative prediction were used. The study of consumer opinion revealed the demand of Russian buyers for curd products enriched with BAS and probiotic cultures. The analysis of the regulatory documentation allowed us to form a set of mandatory requirements for the quality of curd cheese and the curd used, as well as a list of raw materials, biotechnological and technological factors required in the technology of curd cheese production. The study of the influence of each type of biotechnological and technological factors on the properties of the finished product has shown that in the biotechnology of enriched cream cheese it is necessary to use starter from pure cultures of lactococci or a mixture of lactococci and thermophilic lactic acid streptococci, acid method of coagulation of milk protein, whey separation by separation or ultrafiltration, introduction of BAS and flavoring fillers with cream in a separate method of normalization, as well as to exclude the use of milkclotting enzyme, and also to eliminate the use of milk-clotting enzymes. The results obtained are the basis for the development of new biotechnologies of curd cheese enriched with BAS and/or probiotic cultures.

For the first time, new sorbents based on polyacrylonitrile (PAN) fiber and transition metal ferrocyanides were obtained. The main difference between the obtained sorbents and the existing ones is the stage of preliminary preparation of the initial support by converting it into the forms PAN-Fe(OH)3 or PAN-MnO2, due to which additional ion exchange groups (carboxyl, carbonyl, etc.) are formed, which increases the amount of ferrocyanide fixed to the support. The best components and conditions for the synthesis of new sorbents were determined (concentration (0.1–0.2 mol/L), as well as pH (1 for sorbents based on PAN-Fe(OH)3, and 1–5—PAN-MnO2) of potassium ferrocyanide solution, concentration of transition metal salts (0.02 mol/L), temperature conditions). The influence of the studied solution composition (pH, concentration of Na+, K+, NH4+ ions) on the cesium distribution coefficients during its recovery by the obtained sorbents was assessed. The possibility of cesium recovery from solutions with pH 1–9 containing macro quantities of cations was demonstrated. The sorbents derived were characterized by modern structural methods such as infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy with EDS analysis. A study of the trace amount sorption of 137Cs was carried out in comparison with commercially available highly efficient sorbents (FNS-10 and Termoksid-35), and it was shown that the resulting sorbents are not inferior to industrial ferrocyanide sorbents and can be used for 137Cs selective sorption from technological solutions and natural waters.

Objective. Development of local clinical protocols for antibacterial therapy of COVID-19-associated bacterial pneumonia in the therapeutic department of the city clinical hospital based on an analysis of the treatment process in patients with COVID-19-associated pneumonia. Materials and Methods. A retrospective analysis of 1382 cases of hospitalization in the therapeutic department of patients with COVID-19-associated pneumonia for the period from 2020 to 2021 was carried out. The structure of etiotropic therapy, the frequency and timing of microbiological studies of the biomaterial, the manifestations of the main markers of bacterial infection during dynamic monitoring of clinical and laboratory parameters in patients prescribed antibiotic therapy, as well as statistics of the stay of patients in the therapeutic department of the hospital were assessed. Based on the results obtained in the course of microbiological studies, an assessment was made of the microbial landscape of the lower respiratory tract of patients with an analysis of the sensitivity of strains of the leading microflora to a wide range of antibiotics. Results. The study found that the dominant flora in COVID-19-associated pneumonia in hospitalized patients was gram-negative bacteria – K. pneumoniae, P. aeruginosa and A. baumannii – their proportion was more than 50%. Among K. pneumoniae strains, 89.4% were ESBL producers, 63.5% of the strains were resistant to carbapenems, which with a high probability allows them to be considered carbapenemaseproducing strains. Among the strains of P. aeruginosa, the proportion of strains resistant to carbapenems and with a high degree of probability being strains – producers of carbapenemase was 41.1%. Among strains of Acinetobacter spp. these were 76.4%, and associated resistance to fluoroquinolones and aminoglycosides was also demonstrated. Gram-positive microorganisms were found in 34.3% of cases and were mainly represented by strains of S. aureus (74.9%), only 26.4% of strains of this pathogen were methicillin-resistant. Conclusions. Microbiological monitoring conducted in 2020–2021 revealed the presence, among the pathogens of viral-bacterial pneumonia, at an early stage of hospitalization, a significant proportion of gram-negative bacteria with resistance of the MDR and XDR types. Based on the obtained microbiological data, starting empirical schemes for antibacterial therapy of secondary viral and bacterial pneumonia, which complicated the course of a new coronavirus infection COVID-19 caused by the SARS-CoV-2 virus, were developed and proposed.

The goal is this paper is to study - thoroughly and systemically - the experience of developing countries in human capital management, determine its most perspective directions, and prepare the methodological recommendations for the most precise measuring and applied recommendations for the most effective management of human capital quality in developing countries. The originality of this paper is due to a new treatment of human capital quality - from the positions of the contribution to socio-economic development. According to a new treatment, an authors' methodology of evaluation of human capital quality in developing countries is developed. Its application allows proving the imperfection of the existing approach to the management of human capital quality in developing countries and low quality in 2020 (below 0.3 for all countries, and 0.07 on average). For developing countries in the period until 2030, it is recommended to focus on the most perspective directions: increase of the level of digital/technological skills (weight: 0.25), an increase of employee training (weight: 0.17), international experience (weight: 0.14), and increase of foreign highly skilled personnel (weight: 0.14). According to the optimistic scenario, the quality of human capital will grow in most directions in developing countries in the period until 2030, which will ensure the increase of output per worker by 37.06%, economic growth rate by 26.92%, the Global Competitiveness Index by 25.07%, and the Quality of Life Index by 13.23%.

Only high-quality products are competitive, and competitive products have to meet all kinds of requirements, from regulatory documentation to consumer expectations. Functional foods, such as yogurt, are designed with targeted properties, which is a complex task that requires a methodologically universal approach. The research objective was to develop and test a new approach to developing the targeted properties in functional yoghurts. The research featured a new technology and formulation of functional yogurt with sea buckthorn and cryopowdered germinated rye. The study involved qualimetric forecasting methodology, as well as standard quality assessment tools and methods. The new approach included several stages: 1) identifying requirements for product quality and production processes, 2) analyzing discrepancy reports, 3) predicting the effect of quality-forming factors, and 4) developing universal solutions to ensure the required properties. The research resulted in a nomenclature of consumer expectation indicators and a comprehensive assessment formula. It revealed the reasons behind the poor quality of yogurt at different stages. The key requirements for yoghurt included: 1) high moisture-binding capacity, 2) natural functional ingredients that give the product high consumer properties and reduce the risk of microbiological spoilage. The article introduces a formulation and production technology for the new functional yogurt, which proved to have a high content of vitamin C, potassium, and β-carotene. The sensory evaluation demonstrated its high consumer properties. The new approach to the development and production technology proved to be effective. It can be used in the design and quality control of yoghurts with functional ingredients.

Today organizations of the oil-producing complex are not limited to financial reporting forms that are mandatory for submission by national and international standards, but also compile reports on sustainable development, corporate social responsibility, environmental reporting, collectively referred to as integrated reporting. The increased attention of interested users and, mainly, investors, to environmental and social problems determine the importance and importance of the formation of integrated reporting by companies, disclosing information on both financial and non-financial indicators. In modern conditions, when the problem of climate change becomes more acute, the COVID-19 pandemic continues, the fight against corruption is underway, companies will apply the practice of disclosing ESG investment factors in reporting. Accordingly, in order to attract investors, Russian firms need to strive to meet the ESG criteria. Key and potential investors need objective, timely, complete and reliable information to make decisions about investing resources in an enterprise. The disclosure of these components in the reporting is the basis for meeting the information needs of a wide range of users and mainly plays an important role in making investment decisions. The information presented in the integrated reporting is primarily interesting and useful to investors — individuals and legal entities who make or plan to invest their capital in the company’s securities in order to obtain economic benefits and (or) exercise control, since the completeness and transparency of information disclosure in the integrated reporting reflects the investment attractiveness of the company and future benefits. The purpose of the study is to assess the degree of disclosure of information necessary for investors in the integrated reporting of large Russian organizations of the oil production complex. The research method is a quantitative and qualitative rating assessment of the specific weight of ESG factors in the integrated reporting of oil companies. As a result of the study, key ESG factors have been identified, which are currently insufficiently disclosed in non-financial statements of companies. The results of the study can be useful to companies when making decisions about the disclosure of ESG factors in integrated reporting.

The purpose of the study was to investigate the association of carriage of rs9939609 polymorphism in the FTO gene with features of androgen status in men.Material and methods. The observational one-stage examination of 139 male patients aged 22 to 69 years, admitted to a therapeutic hospital in a planned manner has been carried out in the Clinic of the Federal Research Center for Fundamental and Translational Medicine in the period 2020–2021. All fasting men in the morning (8:00–8:30) were carried out of an anthropometric examination to determine physical development, sampling of venous blood from the cubital vein to assess the hormonal parameters of androgen status, and taking a sample of the buccal epithelium for molecular genetic research. Based on the carriage of the rs9939609 (T>A) polymorphism of the FTO gene, the following groups (G) of patients were distinguished: G1 – wild-type homozygotes (WT/WT), G2 – heterozygotes (WT/A), G3 – homozygotes for the mutant allele (A/A).Results and discussion. The statistically significant differences were found in the levels of total testosterone between G1 and G3 (11.6 vs 14.5 nmol/L, p = 0.010), as well as free testosterone in G1 compared to G2 (0.233 vs 0.287 nmol/L, p = 0.012) and G3 (0.233 vs 0.321 nmol/L, p = 0.002) when analyzing the clinical-anthropometric and hormonal features of the androgen status of the examined male patients in the selected groups. Assessment of the association revealed statistically significant positive correlations between the carriage of the mutant allele and the levels of total (r = 0.247; p = 0.013) and free (r = 0.296; p = 0.003) testosterone, and negative - with the frequency of androgen deficiency according to the free testosterone criteria (r = –0.240; p = 0.016).Conclusions. It has been shown that the carriage of the A/A genotype of rs9939609 polymorphism of the FTO gene is associated with an increase in the levels of total and free testosterone, that indicates a protective effect against the development of androgen deficiency in men. The obtained results suggest that this effect is due to the epigenetic effect of the FTO gene protein product on the expression of other genes involved in the synthesis of androgens in the gonads, but also in the adrenal cortex since no association of the carriage of the rs9939609 polymorphism of the FTO gene with the DHEA-C level was found.

Successful food production business depends on how well entrepreneurs identify, assess, and take into account various risks, including technological, at the stage of product design. The analysis of quality complaints and consumer opinions is vital for product design or improvement. The research objective was to develop structured dairy products based on the quality complaint analysis and risk qualimetry. The research featured quality complaints and factors that affect the quality of structured dairy products. It involved the methodology of the technological risk qualimetry and generally accepted control tools and quality assessment methods. Popular structured dairy products were identified and tested for the weight coefficients of their consumer properties and technological risks. The analysis covered five years of quality complaints and made it possible to identify and rank the reasons behind nonconforming structured dairy products. Matrix diagrams helped to forecast various factors, e.g. those based on raw materials or formulation, technological, organizational, etc. The diagrams reflected the degree of factor influence onthe identified risks. The research established control coefficients of each risk, as well as the importance of each factor as a risk management tool. The article introduces several risk management tools related to nonconforming products and aimed at improving consumer properties at the design stage. It also features the formulation of a new structured curd product with production technology and technical documentation. The proposed approach to the development of structured dairy products is based on risk qualimetry and takes into account quality complaints. It provides a prompt formulation assessment, guarantees high consumer properties, and minimizes the risks of producing nonconforming products.

The article is dedicated to the examination of the implementation by a Christian religious organization of various activities aimed at achieving the goals of sustainable development. The testing ground is the Viborg Diocese, one of the northern dioceses of the Evangelical Lutheran Church of Denmark (ELCD), located within the mainland of the country. Based on the analysis of the content of the reporting financial documentation, a detailed description of the economic activity of a religious organization is presented, its regional specificity is indicated. The functions of the ELCD are identified, which are delegated to it by the state and partially duplicate its social obligations. On the example of the Diocese of Viborg the key directions in the field of interaction between the Church and the state are reflected in detail. An analysis of the factual materials led to the conclusion that in communes geographically coinciding with the designated diocese, the religious institution has the greatest influence on the achievement of socially oriented UN SDGs. Priority areas are: access to continuing education, intellectual development, physical and mental health of children and youth, strengthening family relations. The experience of the ELCD regional structural unit in achieving environmentally determined SDGs is also described. A rare example of the implementation of a joint social project of the Diocese of Viborg and municipal authorities in the commune of Ikast-Branne, aimed at providing comprehensive support to families in need, is highlighted. The Evangelical Lutheran Church of Denmark in the XXI century, when the society is embraced by the processes of secularization, remains an influential social institution, showing high activity through participation in various activities aimed at realizing social responsibility at the local and regional levels, so its experience can be useful for other countries and religious organizations.