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In active surveillance of prostate cancer, cancer progression is interval-censored and the examination to detect progression is subject to misclassification, usually false negatives. Meanwhile, patients may initiate early treatment before progression detection, constituting a competing risk. We developed the Misclassification-Corrected Interval-censored Cause-specific Joint Model (MCICJM) to estimate the association between longitudinal biomarkers and cancer progression in this setting. The sensitivity of the examination is considered in the likelihood of this model via a parameter that may be set to a specific value if the sensitivity is known, or for which a prior distribution can be specified if the sensitivity is unknown. Our simulation results show that misspecification of the sensitivity parameter or ignoring it entirely impacts the model parameters, especially the parameter uncertainty and the baseline hazards. Moreover, specification of a prior distribution for the sensitivity parameter may reduce the risk of misspecification in settings where the exact sensitivity is unknown, but may cause identifiability issues. Thus, imposing restrictions on the baseline hazards is recommended. A trade-off between modelling with a sensitivity constant at the risk of misspecification and a sensitivity prior at the cost of flexibility needs to be decided.

Cooperatively utilizing both ego-vehicle and infrastructure sensor data via V2X communication has emerged as a promising approach for advanced autonomous driving. However, current research mainly focuses on improving individual modules, rather than taking end-to-end learning to optimize final planning performance, resulting in underutilized data potential. In this paper, we introduce UniV2X, a pioneering cooperative autonomous driving framework that seamlessly integrates all key driving modules across diverse views into a unified network. We propose a sparse-dense hybrid data transmission and fusion mechanism for effective vehicle-infrastructure cooperation, offering three advantages: 1) Effective for simultaneously enhancing agent perception, online mapping, and occupancy prediction, ultimately improving planning performance. 2) Transmission-friendly for practical and limited communication conditions. 3) Reliable data fusion with interpretability of this hybrid data. We implement UniV2X, as well as reproducing several benchmark methods, on the challenging DAIR-V2X, the real-world cooperative driving dataset. Experimental results demonstrate the effectiveness of UniV2X in significantly enhancing planning performance, as well as all intermediate output performance. Code is at https://github.com/AIR-THU/UniV2X.

Utilizing infrastructure and vehicle-side information to track and forecast the behaviors of surrounding traffic participants can significantly improve decision-making and safety in autonomous driving. However, the lack of real-world sequential datasets limits research in this area. To address this issue, we introduce V2X-Seq, the first large-scale sequential V2X dataset, which includes data frames, trajectories, vector maps, and traffic lights captured from natural scenery. V2X-Seq comprises two parts: the sequential perception dataset, which includes more than 15,000 frames captured from 95 scenarios, and the trajectory forecasting dataset, which contains about 80,000 infrastructure-view scenarios, 80,000 vehicle-view scenarios, and 50,000 cooperative-view scenarios captured from 28 intersections' areas, covering 672 hours of data. Based on V2X-Seq, we introduce three new tasks for vehicle-infrastructure cooperative (VIC) autonomous driving: VIC3D Tracking, Online-VIC Forecasting, and Offline-VIC Forecasting. We also provide benchmarks for the introduced tasks. Find data, code, and more up-to-date information at \href{https://github.com/AIR-THU/DAIR-V2X-Seq}{https://github.com/AIR-THU/DAIR-V2X-Seq}., Comment: CVPR2023

Decays of unstable heavy particles usually involve the coherent sum of several amplitudes, like in a multiple slit experiment. Dedicated amplitude analysis techniques have been widely used to resolve these amplitudes for better understanding of the underlying dynamics. For special cases, where two spin-1/2 particles and two (pseudo-)scalar particles are present in the process, multiple equivalent solutions are found due to intrinsic symmetries in the summed probability density function. In this paper, the problem of multiple solutions is discussed and a scheme to overcome this problem is proposed by fixing some free parameters. Toys are generated to validate the strategy. A new approach to align helicities of initial- and final-state particles in different decay chains is also introduced., Comment: 17 pages, 2 figures

Active surveillance (AS), where biopsies are conducted to detect cancer progression, has been acknowledged as an efficient way to reduce the overtreatment of prostate cancer. Most AS cohorts use fixed biopsy schedules for all patients. However, the ideal test frequency remains unknown, and the routine use of such invasive tests burdens the patients. An emerging idea is to generate personalized biopsy schedules based on each patient's progression-specific risk. To achieve that, we propose the interval-censored cause-specific joint model (ICJM), which models the impact of longitudinal biomarkers on cancer progression while considering the competing event of early treatment initiation. The underlying likelihood function incorporates the interval-censoring of cancer progression, the competing risk of treatment, and the uncertainty about whether cancer progression occurred since the last biopsy in patients that are right-censored or experience the competing event. The model can produce patient-specific risk profiles until a horizon time. If the risk exceeds a certain threshold, a biopsy is conducted. The optimal threshold can be chosen by balancing two indicators of the biopsy schedules: the expected number of biopsies and expected delay in detection of cancer progression. A simulation study showed that our personalized schedules could considerably reduce the number of biopsies per patient by 34%-54% compared to the fixed schedules, though at the cost of a slightly longer detection delay.

Heavy flavour physics provides excellent opportunities to indirectly search for new physics at very high energy scales and to study hadron properties for deep understanding of the strong interaction. The LHCb experiment has been playing a leading role in the study of heavy flavour physics since the start of the LHC operations about ten years ago, and made a range of high-precision measurements and unexpected discoveries, which may have far-reaching implications on the field of particle physics. This review highlights a selection of the most influential physics results on CP violation, rare decays, and heavy flavour production and spectroscopy obtained by LHCb using the data collected during the first two operation periods of the LHC. The upgrade plan of LHCb and the physics prospects are also briefly discussed., Comment: Invited review for Frontiers of Physics

Compositional data are non-negative data collected in a rectangular matrix with a constant row sum. Due to the non-negativity the focus is on conditional proportions that add up to 1 for each row. A row of conditional proportions is called an observed budget. Latent budget analysis (LBA) assumes a mixture of latent budgets that explains the observed budgets. LBA is usually fitted to a contingency table, where the rows are levels of one or more explanatory variables and the columns the levels of a response variable. In prospective studies, there is only knowledge about the explanatory variables of individuals and interest goes out to predicting the response variable. Thus, a form of LBA is needed that has the functionality of prediction. Previous studies proposed a constrained neural network (NN) extension of LBA that was hampered by an unsatisfying prediction ability. Here we propose LBA-NN, a feed forward NN model that yields a similar interpretation to LBA but equips LBA with a better ability of prediction. A stable and plausible interpretation of LBA-NN is obtained through the use of importance plots and table, that show the relative importance of all explanatory variables on the response variable. An LBA-NN-K- means approach that applies K-means clustering on the importance table is used to produce K clusters that are comparable to K latent budgets in LBA. Here we provide different experiments where LBA-NN is implemented and compared with LBA. In our analysis, LBA-NN outperforms LBA in prediction in terms of accuracy, specificity, recall and mean square error. We provide open-source software at GitHub.

Classical deep learning algorithms have aroused great interest in both academia and industry for their utility in image recognition, language translation, decision-making problems and more. In this work, we have provided a quantum deep learning scheme based on multi-qubit entanglement states, including computation and training of neural network in full quantum process. In the course of training, efficient calculation of the distance between unknown unit vector and known unit vector has been realized by proper measurement based on the Greenberger-Horne-Zeilinger entanglement states. An exponential speedup over classical algorithms has been demonstrated. In the process of computation, quantum scheme corresponding to multi-layer feedforward neural network has been provided. We have shown the utility of our scheme using Iris dataset. The extensibility of the present scheme to different types of model has also been analyzed, Comment: Will appear in New Journal of Physics

For the International Large Detector concept at the planned International Linear Collider, the use of time projection chambers (TPC) with micro-pattern gas detector readout as the main tracking detector is investigated. In this paper, results from a prototype TPC, placed in a 1 T solenoidal field and read out with three independent GEM-based readout modules, are reported. The TPC was exposed to a 6 GeV electron beam at the DESY II synchrotron. The efficiency for reconstructing hits, the measurement of the drift velocity, the space point resolution and the control of field inhomogeneities are presented., Comment: 22 pages, 19 figures

Jinping Neutrino Experiment (Jinping) is proposed to significantly improve measurements on solar neutrinos and geoneutrinos in China Jinping Laboratory - a lab with a number of unparalleled features, thickest overburden, lowest reactor neutrino background, etc., which identify it as the world-best low-energy neutrino laboratory. The proposed experiment will have target mass of 4 kilotons of liquid scintillator or water-based liquid scintillator, with a fiducial mass of 2 kilotons for neutrino-electron scattering events and 3 kilotons for inverse-beta interaction events. A number of initial sensitivities studies have been carried out, including on the transition phase for the solar neutrinos oscillation from the vacuum to the matter effect, the discovery of solar neutrinos from the carbon-nitrogen-oxygen (CNO) cycle, the resolution of the high and low metallicity hypotheses, and the unambiguous separation on U and Th cascade decays from the dominant crustal anti-electron neutrinos in China., Comment: Proposal for the Jinping Neutrino Experiment